CHiP Network Congenital Heart Journal Watch – March 2020

Pediatric Cardiology Featured Articles

Pediatric Cardiology Reviews of January 2020 Manuscripts

New Screening Tool for Aortic Root Dilation in Children with Marfan Syndrome and Marfan-Like Disorders.

Wozniak-Mielczarek L, Sabiniewicz R, Nowak R, Gilis-Malinowska N, Osowicka M, Mielczarek M.

Pediatr Cardiol. 2020 Jan 31. doi: 10.1007/s00246-020-02307-0. [Epub ahead of print]

PMID: 32006082

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Take Home Points:

  • Aortic root ratio may be another helpful screening measurement for aortic root dilation in patients with suspected connective tissue disorders
  • This study did not assess normal patients or patients with other etiologies for aortic root dilation (such as BAV)
  • Whether cumulative changes such as rate of change or significant change would improve morbidity/mortality or be useful for surgical intervention remains to be seen

 

 

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch:  Similar to nearly all echo measurements in children, the aortic diameter is affected by a patient’s age, sex, and BSA. Z-scores are used to allow for the necessary adjustments in order to determine if something is within the normal range. There are currently 3 main z-score nomograms used. Based on a premise that z-score calculations are time consuming and impractical, this study aimed to introduce a simple screening method to identify aortic root dilation. The authors retrospectively analyzed 193 patients with Marfan Syndrome (MFS) or Marfan-like disorders (including Ehlers-Danlos, Loeys-Dietz, ectopia lentis, neonatal Marfan, MASS phenotype, and Marfanoid habitus). Marfanoid habitus was defined as a constellation of symptoms similar to MFS but did not fully meet Ghent criteria. The mean age was 12 years. The aortic root (sinuses of Valsalva only) was measured in the parasternal long axis view using both the leading edge in end-diastole and the inner edge in mid-systole. The aortic root ratio (ARr) was calculated as the aortic root diameter (mm) divided by the height (cm) multiplied by 100. This was compared to the 2 measurement techniques and z-scores using all 3 nomograms.

28-31 % of the patients had aortic root dilation as expressed by z-score (z > 2) depending on which nomogram was used. 11 patients (5.79%) had inconsistent results (dilated vs. non-dilated) when comparing z-score nomograms (Gautier vs. Cantinotti only). The mean value for ARr was 18.1 vs. 17.8 for the leading edge vs. inner edge measurements. The optimal cut-off for ARr was > 18.7 with resulted in a sensitivity of 88-100% and specificity of 94-98% (Table 7).

The authors further assessed the subgroup in whom the ARr failed to identify aortic root dilation. They found the results were inconsistent using the 3 different nomograms. Notably, a detailed table shows that all of the z-scores of this group were either just below or just above 2. ROC curves showed an ARr > 18 yielded a sensitivity of 100% for the Petterson and Cantinotti nomograms and > 18.7 for the Gautier nomogram. Tables 10 and 11 show the high values of PPV, NPV and accuracy of ARr using the various cut-offs.

The authors make a reasonable argument that extremely thin or obese patients may have inaccurate z-scores, and based on previous data that height is more important than BSA for aortic root diameter, the ARr may be useful. There are however a few major caveats to this study. First, ARr only assess the aortic root at the sinuses. It will therefore not be useful in those with significant annular dilation or ascending aorta dilation, and we know that surgical decision making often entails valve sparing vs. non-sparing aortic root replacement. Additionally, the Marfan-like subgroup was large and may not represent a normal population for which this measurement has not been validated. They also did not include a BAV/aortic root dilation group, or other groups with CHD such as TOF or d-TGA s/p ASO, which may have a different form of aortic root dilation than the genetic connective tissue disorder group. Finally, the claim that nomograms are difficult to use may be a bit spurious, given that many reporting software and measurement packages on the echo equipment may automatically calculate z-scores. It is interesting to note that there may be variation depending on the nomogram used, so echo readers should keep this in mind based on the specific software algorithms used. However, most of these patients would have routine follow up, so a “missed” diagnosis when the z-score is 1.9 is probably not too clinically relevant. Since this was a one-time measurement study, further research on the ARr over time would be necessary, since rate of change is also a key factor in decision making.

 

The Utility of Echocardiography in Pediatric Patients with Structurally Normal Hearts and Suspected Endocarditis.

Kelly P, Hua N, Madriago EJ, Holmes KW, Shaughnessy R, Ronai C.

Pediatr Cardiol. 2020 Jan;41(1):62-68. doi: 10.1007/s00246-019-02222-z. Epub 2019 Oct 31.

PMID: 31673735

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Take Home Points:

  • A single positive blood culture without other major or minor Modified Duke’s Criteria (MDC) and no prior history of congenital heart disease has a positive predictive value of 0 for infectious endocarditis (IE)
  • Two positive cultures without other criteria also has a very low PPV
  • MDC should be used to assess the clinical probability of IE; if low, a TTE is not recommended due to poor diagnostic yield

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch:  While sonographic findings are part of the major criteria for MDC, they are usually meant to supplement clinical judgment when there is a higher pretest probability of IE. The sensitivity and specificity in adults is not great for IE, and the ACC/AHA calls TTE an inadequate screening tool. This study was a retrospective chart review to determine the diagnostic yield of TTE in children with suspected IE and structurally normal hearts and no prior history of IE. 300 patients were included. Charts were reviewed to determine whether patients met any MDC prior to the echocardiogram. Clinical IE was determined if patients were treated with 4-6 weeks of IV antibiotics. Positive TTE findings were defined as mass, abscess, thrombus or new significant valvular regurgitation.

Over the 10 year study period, 10/300 (3.3%) had positive TTE findings. Of those 10 patients, 8 were treated for IE with 2 false positives that the authors detail. Of the 290 with negative TTE, 3 were diagnosed with IE. These were all teenagers with poorer echo images and clinical features strongly suggestive of IE. See tables 3 and 4.  98 patients (33%) had 2 positive blood cultures; 7 were diagnosed with IE, with one likely having a false positive TTE and the other 6 having some MDC. The PPV of 2 positive cultures and no MDC risk factors was 0.071. 46 patients (15.3%) had only 1 positive blood culture. The PPV of 1 positive culture and no additional MDC risk factors was 0. The PPV of those that met MDC prior to TTE was 0.86. See table 5.

There was pretty clear data that those with 1 or 2 positive blood cultures and no other MDC risk factors have a very low likelihood of IE and a positive echo. Misdiagnosis of IE obviously has increased morbidity (need for CVL and antibiotics) and TTE can have false positives. Therefore, use of MDC should be strongly recommended prior to obtaining a TTE. A few caveats/limitations include poor documentation of various vascular and immunologic findings in their chart review. Additionally, while presence of CHD is a risk factor, this study does not address the risk/PPV in this population.

 

Human Milk Use in the Preoperative Period Is Associated with a Lower Risk for Necrotizing Enterocolitis in Neonates with Complex Congenital Heart Disease.

Cognata A, Kataria-Hale J, Griffiths P, Maskatia S, Rios D, O’Donnell A, Roddy DJ, Mehollin-Ray A, Hagan J, Placencia J, Hair AB.

J Pediatr. 2019 Dec;215:11-16.e2. doi: 10.1016/j.jpeds.2019.08.009. Epub 2019 Sep 24.

PMID:  31561958

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Take Home Points:

  • In infants with isolated critical congenital heart lesions, the incidence of preoperative necrotizing enterocolitis (NEC) was 3.3% and developed at a median of 5 days after initiation of feeds.
  • Large volume feeding (>100ml/kg/d) of infants with critical heart disease in the preoperative period is associated with a 3-fold increase in the risk of NEC
  • Infants who are exclusively fed with unfortified human milk diet had a significantly lower risk of preoperative NEC.

 

Commentary from Dr. Venu Amula (Salt Lake City), section editor of Pediatric Cardiology Journal Watch:  In this retrospective, single-center cohort study of infants of any gestational age with isolated critical congenital heart lesion between January 2010 and January 2016, the authors evaluated whether large feeding volumes (> 100ml/kg/d) and exposure to cow’s milk formula increased the risk of preoperative Necrotizing Enterocolitis (NEC). NEC was defined based on the modified Bell criteria. The cardiac lesions included were those with a high risk of NEC – ductal dependent lesions, transposition of great arteries, truncus arteriosus, aortopulmonary window, severe Ebstein’s anomaly and tetralogy of Fallot with absent PV. Infants were excluded if they were admitted at >72 hours of age or had heterotaxy, major gastrointestinal anomalies or hypoxic-ischemic encephalopathy. Infants with cardiac anomalies that did not require intervention were also excluded. Demographic data were collected for all the infants who met inclusion criteria. Feeding data included date feeds were initiated; type of feeds provided; the largest volume of feeds (mL/kg/d) provided; and the feeding route that was used (oral vs nasogastric).

The association of volume of feeds (> 100ml/kg/d or less) and type of formula (cow’s milk) with the incidence of NEC in the preoperative period was evaluated in a multivariable logistic regression model that was built by including clinically relevant and all other risk factors found to be significantly associated with NEC (P = .05) in univariate analysis.

After screening 878 infants 546 were found to be eligible for the study. The incidence of NEC was 3.3% before the surgery and developed a median of 5 days after feeds were started. Large volume feeds defined as feeding volume more than 100 ml/kg/day was associated with an increased risk of NEC. Exclusive unfortified human milk diet was protective, with a significantly lower risk for NEC when controlled for other risk factors like feeding volume, birth weight small for gestational age, race, inotropic support preoperatively/pre-NEC, prematurity (gestational age <37 weeks), and cardiac lesion. Infants with biventricular ductal dependent blood flow had increased risk of NEC but were probably confounded by the fact that they were younger, had long wait times before surgery and were fed high volume, nonhuman milk diet.

The study is limited by being an evaluation of a single-center practice and outcomes and as such the results may not be generalizable, however, the sample size is large and contained decent case-mix severity. Like other studies on necrotizing enterocolitis, the definition of NEC and Bell staging, especially for stage 1 ( 8 out of 18) is subjective as acknowledged by the authors but every effort was taken to standardize. Whether these risk factors apply to severe stages of NEC is unclear due to the rarity of the outcomes in comparison to sample size when analyzed separately. The study suggests that caution should be exercised in the preoperative period when feeding infants with critical heart lesions of any gestational age regardless of the type and ductal dependency. Feeding volumes < 100ml/kg/d and using unfortified human milk diet seem to decrease the risk of this GI complication with major morbidity.

 

What is the Significance of Elevated Troponin I in Children and Adolescents? A Diagnostic Approach.

Yoldaş T, Örün UA.

Pediatr Cardiol. 2019 Dec;40(8):1638-1644. doi: 10.1007/s00246-019-02198-w. Epub 2019 Sep 4.

PMID:   31485699

 

Take Home Points:

 

  • A single-center evaluation of children with no known prior heart disease, who presented with elevated troponin I, showed association with diverse cardiac and noncardiac pathologies.
  • The most frequent cause of elevated troponin I is myopericarditis (46%). Perimyocarditis is associated with higher peak troponin I levels and takes a long time to normalize.
  • Most frequent non-cardiac causes include drug intoxication, carbon-monoxide poisoning. Intensive inhalation beta-agonist use in acute asthma and lower respiratory tract infections.
  • A careful history, physical examination, Electrocardiogram, and Echocardiogram to evaluate function should form the basis for differentiating cardiac and noncardiac etiologies. CT angiography and Magnetic Resonance Imaging were performed in few patients.
  • Unlike adults, coronary involvement is rare and cardiac catheterization is not routinely warranted except when rare pathology is suspected.

 

Commentary from Dr. Venu Amula MD (Salt Lake City), section editor of Pediatric Cardiology Journal Watch:  Troponin I is an important cardiac biomarker and its elevation in adult patients signifies coronary artery disease. Myocardial injury and elevated troponin, though rare in children, create considerable anxiety among pediatric providers. In the current study, Yoldas et al aim to evaluate the significance of elevated Troponin I in a retrospective cohort of children less than 18 years of age admitted to a single-center between 2007 – 2018. They excluded children with a history of congenital heart disease and those requiring or having undergone cardiac surgery within the previous year. Neonates with birth asphyxia and sepsis were also excluded. For those who met inclusion criteria demographics, clinical and other diagnostic data were abstracted from medical records and analyzed using descriptive statistics.

Troponin elevation was defined as >0.06 ng/ml per the institute’s laboratory standard. Of the patients with elevated Troponin I, ECG findings, echocardiography and degree of troponin elevation were evaluated along with the final diagnosis sorted by cardiac and non-cardiac etiologies. The peak troponin levels were also compared between those with cardiac and noncardiac etiologies.

They screened 972 patient records and found 759 subjects meeting the study criteria. Evaluation of troponin was done for the most common indication of chest pain and syncope within 2 weeks of presentation. The most common cardiac causes of raised troponin were myopericarditis (46%), perimyocarditis (18%), cardiomyopathy (15%), followed by dysrhythmias (12%). The most common indication for performing troponin I test in the non-cardiac group was to investigate cardiac involvement in drug intoxications. The other reasons were carbon monoxide Poisoning and respiratory symptoms. Patients with myopericarditis and perimyocarditis had distinct characteristics of troponin elevation. Patients with perimyocarditis had higher peak troponins and also took a long time to negative troponin, not surprising given the predominance of myocardial inflammation.

The study provides a framework for differential diagnosis of elevated troponin I testing in children with no congenital heart disease. Providers should be wary of the implications of routine testing of troponin I levels. A careful review of history, indication for testing, physical examination findings should be corroborated by ECG and echocardiogram to interpret the elevated troponin I levels. Short of this, providers may produce an undue burden of anxiety for patients and themselves.

 

Pediatric cardiology Jan 2020

  1. New Screening Tool for Aortic Root Dilation in Children with Marfan Syndrome and Marfan-Like Disorders.

Wozniak-Mielczarek L, Sabiniewicz R, Nowak R, Gilis-Malinowska N, Osowicka M, Mielczarek M.

Pediatr Cardiol. 2020 Jan 31. doi: 10.1007/s00246-020-02307-0. [Epub ahead of print]

PMID: 32006082

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  1. Smith-Lemli-Opitz Syndrome.

Nowaczyk MJM, Wassif CA.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020.
1998 Nov 13 [updated 2020 Jan 30].

PMID: 20301322 Free Books & Documents

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  1. Left-right patterning in congenital heart disease beyond heterotaxy.

Gabriel GC, Lo CW.

Am J Med Genet C Semin Med Genet. 2020 Jan 30. doi: 10.1002/ajmg.c.31768. [Epub ahead of print]

PMID: 31999049

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  1. Genetics and other omics in pediatric pulmonary arterial hypertension.

Welch CL, Chung WK.

Chest. 2020 Jan 29. pii: S0012-3692(20)30136-7. doi: 10.1016/j.chest.2020.01.013. [Epub ahead of print] Review.

PMID: 32006592

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  1. Diagnosis and Management of Critical Congenital Heart Diseases in the Newborn.

Krishna MR, Kumar RK.

Indian J Pediatr. 2020 Jan 28. doi: 10.1007/s12098-019-03163-4. [Epub ahead of print] Review.

PMID: 31989462

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  1. Feeding difficulty and gastrostomy tube placement in infants with Down syndrome.

Poskanzer SA, Hobensack VL, Ciciora SL, Santoro SL.

Eur J Pediatr. 2020 Jan 27. doi: 10.1007/s00431-020-03591-x. [Epub ahead of print]

PMID: 31984440

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  1. Novel KLHL26 variant associated with a familial case of Ebstein’s anomaly and left ventricular noncompaction.

Samudrala SSK, North LM, Stamm KD, Earing MG, Frommelt MA, Willes R, Tripathi S, Dsouza NR, Zimmermann MT, Mahnke DK, Liang HL, Lund M, Lin CW, Geddes GC, Mitchell ME, Tomita-Mitchell A.

Mol Genet Genomic Med. 2020 Jan 27:e1152. doi: 10.1002/mgg3.1152. [Epub ahead of print]

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  1. Heart rate changes following the administration of sugammadex in children: a prospective, observational study.

Alsuhebani M, Sims T, Hansen JK, Hakim M, Walia H, Miller R, Tumin D, Tobias JD.

J Anesth. 2020 Jan 24. doi: 10.1007/s00540-019-02729-y. [Epub ahead of print]

PMID: 31980926

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  1. Bridging the Cardiac Needs of a Large, Underserved Immigrant and Resettled Refugee Population.

Agrawal H, Dokania G, Allen HD, Acosta S, Caracostis A, Havemann LM, Lara A, Riley AF, Seery TJ.

J Pediatr. 2020 Jan 24. pii: S0022-3476(19)31701-9. doi: 10.1016/j.jpeds.2019.12.022. [Epub ahead of print]

PMID: 31987651

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  1. Highly accelerated, real-time phase-contrast MRI using radial k-space sampling and GROG-GRASP reconstruction: a feasibility study in pediatric patients with congenital heart disease.

Haji-Valizadeh H, Feng L, Ma LE, Shen D, Block KT, Robinson JD, Markl M, Rigsby CK, Kim D.

NMR Biomed. 2020 Jan 24:e4240. doi: 10.1002/nbm.4240. [Epub ahead of print]

PMID: 31977117

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  1. Routine Surveillance Catheterization is Useful in Guiding Management of Stable Fontan Patients.

Patel ND, Sullivan PM, Sabati A, Hill A, Maedler-Kron C, Zhou S, Shillingford N, Williams R, Takao C, Badran S.

Pediatr Cardiol. 2020 Jan 24. doi: 10.1007/s00246-020-02293-3. [Epub ahead of print]

PMID: 31980851

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  1. High Altitude as a Cause of Congenital Heart Defects: A Medical Hypothesis Rediscovered in Ecuador.

González-Andrade F.

High Alt Med Biol. 2020 Jan 23. doi: 10.1089/ham.2019.0110. [Epub ahead of print]

PMID: 31976751

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  1. Imaging of the pulmonary vasculature in congenital heart disease without gadolinium contrast: Intraindividual comparison of a novel Compressed SENSE accelerated 3D modified REACT with 4D contrast-enhanced magnetic resonance angiography.

Pennig L, Wagner A, Weiss K, Lennartz S, Grunz JP, Maintz D, Laukamp KR, Hickethier T, Naehle CP, Bunck AC, Doerner J.

J Cardiovasc Magn Reson. 2020 Jan 23;22(1):8. doi: 10.1186/s12968-019-0591-y.

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  1. A scoping review and mapping exercise comparing the content of patient-reported outcome measures (PROMs) across heart disease-specific scales.

Algurén B, Coenen M, Malm D, Fridlund B, Mårtensson J, Årestedt K; Collaboration and Exchange in Swedish cardiovascular caring Academic Research (CESAR) group.

J Patient Rep Outcomes. 2020 Jan 23;4(1):7. doi: 10.1186/s41687-019-0165-7. Review.

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  1. Kangaroo Care for Hospitalized Infants with Congenital Heart Disease.

Lisanti AJ, Buoni A, Steigerwalt M, Daly M, McNelis S, Spatz DL.

MCN Am J Matern Child Nurs. 2020 Jan 23. doi: 10.1097/NMC.0000000000000612. [Epub ahead of print]

PMID: 31977496

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  1. Effective myocardial perfusion and concomitant haemodynamic status determine the clinical diversity of anomalous left coronary artery from the pulmonary artery.

Matoq AA, Tsuda T.

Cardiol Young. 2020 Jan 22:1-7. doi: 10.1017/S1047951119003299. [Epub ahead of print]

PMID: 31964440

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  1. Prediction of Pulmonary to Systemic Flow Ratio in Patients With Congenital Heart Disease Using Deep Learning-Based Analysis of Chest Radiographs.

Toba S, Mitani Y, Yodoya N, Ohashi H, Sawada H, Hayakawa H, Hirayama M, Futsuki A, Yamamoto N, Ito H, Konuma T, Shimpo H, Takao M.

JAMA Cardiol. 2020 Jan 22. doi: 10.1001/jamacardio.2019.5620. [Epub ahead of print]

PMID: 31968049

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  1. Global, regional, and national burden of congenital heart disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

GBD 2017 Congenital Heart Disease Collaborators.

Lancet Child Adolesc Health. 2020 Jan 21. pii: S2352-4642(19)30402-X. doi: 10.1016/S2352-4642(19)30402-X. [Epub ahead of print]

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  1. Congenital heart disease: a global public health concern.

Rossano JW.

Lancet Child Adolesc Health. 2020 Jan 21. pii: S2352-4642(19)30429-8. doi: 10.1016/S2352-4642(19)30429-8. [Epub ahead of print] No abstract available.

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  1. Utilization of Diagnostic Testing for Renal Anomalies and Congenital Heart Disease in Patients with Microtia.

Ramprasad VH, Shaffer AD, Jabbour N.

Otolaryngol Head Neck Surg. 2020 Jan 21:194599820901351. doi: 10.1177/0194599820901351. [Epub ahead of print]

PMID: 31959051

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  1. Drug Treatment of Pulmonary Hypertension in Children.

Avitabile CM, Vorhies EE, Ivy DD.

Paediatr Drugs. 2020 Jan 21. doi: 10.1007/s40272-019-00374-2. [Epub ahead of print] Review.

PMID: 31960361

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  1. Neurodevelopmental outcomes at three years for infants with CHD and VLBW.

Yoshida T, Hiraiwa A, Ibuki K, Makimoto M, Inomata S, Tamura K, Kawasaki Y, Ozawa S, Hirono K, Ichida F.

Pediatr Int. 2020 Jan 19. doi: 10.1111/ped.14160. [Epub ahead of print]

PMID: 31957091

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  1. Making a case for metallothioneins conferring cardioprotection in pulmonary hypertension.

Maarman GJ.

Med Hypotheses. 2020 Jan 18;137:109572. doi: 10.1016/j.mehy.2020.109572. [Epub ahead of print]

PMID: 31986470

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  1. introduce nationwide pulse oximetry screening for the detection of critical congenital heart disease and other hypoxaemic conditions in the newborn.

Cloete E, Gentles TL, Bloomfield FH.

N Z Med J. 2020 Jan 17;133(1508):111-117.

PMID: 31945047

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  1. Resting respiratory lung volumes are “healthier” than exercise respiratory volumes in different types of palliated or corrected congenital heart disease.

Fabi M, Balducci A, Cazzato S, Aceti A, Gallucci M, Di Palmo E, Gargiulo G, Donti A, Lanari M.

Pediatr Pulmonol. 2020 Jan 17. doi: 10.1002/ppul.24640. [Epub ahead of print]

PMID: 31951681

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  1. The Role of 22q11.2 Deletion Syndrome in the Relationship between Congenital Heart Disease and Scoliosis.

Homans JF, de Reuver S, Heung T, Silversides CK, Oechslin EN, Houben ML, McDonald-McGinn DM, Kruyt MC, Castelein RM, Bassett AS.

Spine J. 2020 Jan 17. pii: S1529-9430(20)30007-3. doi: 10.1016/j.spinee.2020.01.006. [Epub ahead of print]

PMID: 31958577

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  1. Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China.

Chen C, Luo F, Wu P, Huang Y, Das A, Chen S, Chen J, Hu X, Li F, Fang Z, Zhou S.

J Cell Mol Med. 2020 Jan 16. doi: 10.1111/jcmm.14937. [Epub ahead of print]

PMID: 31945804 Free Article

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  1. Cytokinesis, Beta-Blockers, and Congenital Heart Disease.

Yutzey KE.

N Engl J Med. 2020 Jan 16;382(3):291-293. doi: 10.1056/NEJMcibr1913824. No abstract available.

PMID: 31940705

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  1. Congenital heart disease in children: Orofacial myofunctional aspects, eating behavior and facial temperature.

Barbosa MDG, Castelo PM, Ferreira CLP, Haddad DS, Chiari BM, Santana MV, Bommarito S.

Int J Pediatr Otorhinolaryngol. 2020 Jan 15;131:109883. doi: 10.1016/j.ijporl.2020.109883. [Epub ahead of print] Review.

PMID: 31968274

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  1. Clinically Asymptomatic Sleep-Disordered Breathing in Infants with Single-Ventricle Physiology.

Stamm RW, Henry BM, Sawnani H, Simakajornboon N, Rulong G, Ollberding NJ, Hanke SP, Dye TJ, Cooper DS.

J Pediatr. 2020 Jan 14. pii: S0022-3476(19)31507-0. doi: 10.1016/j.jpeds.2019.11.005. [Epub ahead of print]

PMID: 31952850

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  1. Gross Motor Development of Children with Congenital Heart Disease Receiving Early Systematic Surveillance and Individualized Intervention: Brief Report.

Fourdain S, Simard MN, Dagenais L, Materassi M, Doussau A, Goulet J, Gagnon K, Prud’Homme J, Vinay MC, Dehaes M, Birca A, Poirier NC, Carmant L, Gallagher A.

Dev Neurorehabil. 2020 Jan 12:1-7. doi: 10.1080/17518423.2020.1711541. [Epub ahead of print]

PMID: 31928274

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  1. Mucopolysaccharidosis-Plus Syndrome.

Vasilev F, Sukhomyasova A, Otomo T.

Int J Mol Sci. 2020 Jan 9;21(2). pii: E421. doi: 10.3390/ijms21020421. Review.

PMID: 31936524 Free Article

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  1. Genes that drive the pathobiology of pediatric pulmonary arterial hypertension.

Welch CL, Austin ED, Chung WK.

Pediatr Pulmonol. 2020 Jan 9. doi: 10.1002/ppul.24637. [Epub ahead of print] Review.

PMID: 31917901

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  1. Blood component utilization before and after implementation of good transfusion practice measures in a pediatric emergency department.

Sharma A, Nallasamy K, Jain A, Williams V, Jayashree M.

Transfus Apher Sci. 2020 Jan 9:102719. doi: 10.1016/j.transci.2020.102719. [Epub ahead of print]

PMID: 31953106

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  1. Other genomic disorders and congenital heart disease.

Lalani SR.

Am J Med Genet C Semin Med Genet. 2020 Jan 7. doi: 10.1002/ajmg.c.31762. [Epub ahead of print]

PMID: 31909881

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  1. Feasibility and accuracy of real-time three-dimensional echocardiography in evaluating the aortic valve in children.

Ezzeldin DA, Roushdy AM, Abdallah AA, El Fiky AA.

Egypt Heart J. 2020 Jan 7;72(1):2. doi: 10.1186/s43044-019-0037-8.

PMID: 31912327 Free PMC Article

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  1. Fontan-Associated Liver Disease: Spectrum of Disease in Children and Adolescents.

Rathgeber SL, Guttman OR, Lee AF, Voss C, Hemphill NM, Schreiber RA, Harris KC.

J Am Heart Assoc. 2020 Jan 7;9(1):e012529. doi: 10.1161/JAHA.119.012529. Epub 2020 Jan 4.

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Select item 31852418

 

38.Management of Persistent Pulmonary Hypertension After Correction of Congenital Heart Defect with Autologous Marrow-Derived Mononuclear Stem Cell Injection into the Pulmonary Artery: A Pilot Study.

Amoozgar H, Banafi P, Mohammadi H, Edraki MR, Mehdizadegan N, Ajami G, Borzouee M, Keshaarz K, Moradi P, Dehghani E.

Pediatr Cardiol. 2020 Jan 7. doi: 10.1007/s00246-019-02273-2. [Epub ahead of print]

PMID: 31912176

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Select item 31905489

 

  1. Multiorgan involvement and management in children with Down syndrome.

Lagan N, Huggard D, Mc Grane F, Leahy TR, Franklin O, Roche E, Webb D, O’ Marcaigh A, Cox D, El-Khuffash A, Greally P, Balfe J, Molloy EJ.

Acta Paediatr. 2020 Jan 3. doi: 10.1111/apa.15153. [Epub ahead of print] Review.

PMID: 31899550

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Select item 32014323

 

  1. [Clinical features of pulmonary thromboembolism of eight children].

Zhang FZ, Yuan JX, Tao XF, Chen ZM, Tang LF.

Zhonghua Er Ke Za Zhi. 2020 Jan 2;58(1):25-29. doi: 10.3760/cma.j.issn.0578-1310.2020.01.007. Chinese.

PMID: 31905472

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Select item 31332832

 

  1. Newborn pulse oximetry screening in the context of a high antenatal detection rate of critical congenital heart disease.

Cloete E, Bloomfield FH, Cassells SA, de Laat MWM, Sadler L, Gentles TL.

Acta Paediatr. 2020 Jan;109(1):93-99. doi: 10.1111/apa.14946. Epub 2019 Sep 2.

PMID: 31332832 Free PMC Article

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Select item 31298757

 

  1. Pulse oximetry screening in a midwifery-led maternity setting with high antenatal detection of congenital heart disease.

Cloete E, Gentles TL, Webster DR, Davidkova S, Dixon LA, Alsweiler JM, Bloomfield FH; Pulse Oximetry Screening Steering Committee.

Acta Paediatr. 2020 Jan;109(1):100-108. doi: 10.1111/apa.14934. Epub 2019 Aug 8.

PMID: 31298757 Free PMC Article

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Select item 31895976

 

  1. Oxygen Saturation and Perfusion Index-Based Enhanced Critical Congenital Heart Disease Screening.

Siefkes H, Kair L, Tancredi DJ, Vasquez B, Garcia L, Bedford-Mu C, Lakshminrusimha S.

Am J Perinatol. 2020 Jan;37(2):158-165. doi: 10.1055/s-0039-1685445. Epub 2019 Apr 19.

PMID: 31003242

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Select item 32011322

 

  1. Characterization of In-Flight Medical Events Involving Children on Commercial Airline Flights.

Rotta AT, Alves PM, Nerwich N, Shein SL.

Ann Emerg Med. 2020 Jan;75(1):66-74. doi: 10.1016/j.annemergmed.2019.06.004. Epub 2019 Jul 25.

PMID: 31353055

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Select item 32030043

 

  1. Caught-off guard: Unguarded mitral valve orifice in usual atrial arrangement with discordant atrioventricular connections and pulmonary atresia.

Banerji N, Krishna MR, Kumar RK, Anderson RH.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):84-86. doi: 10.4103/apc.APC_4_19. Epub 2019 Jun 26.

PMID: 32030042 Free PMC Article

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Select item 32030039

 

  1. Unusual association of transposition of great arteries with infradiaphragmatic pulmonary venous return.

Scrascia G, Grimaldi AMP, Troise D, Scalzo G.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):75-77. doi: 10.4103/apc.APC_54_19. Epub 2019 Dec 4.

PMID: 32030039 Free PMC Article

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Select item 32030038

 

  1. Implementation of diagnostic screening for congenital heart disease in Hidalgo, Mexico.

Atitlán-Gil A, Mendiola-Figueroa LR, Morales-Argüelles VH, Salomón-Ganado A, Medécigo-Castelán E, Erdmenger-Orellana J.

Arch Cardiol Mex. 2020;90(1):39-46. doi: 10.24875/ACM.19000304.

PMID: 31996861 Free Article

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Select item 31494945

 

  1. Rare Association Between Atrioventricular Septal Defect and Partial Anomalous Pulmonary Venous Connection.

Murakami AN, Baston GG, Cardoso MRR, Marchi CH, Croti UA.

Braz J Cardiovasc Surg. 2020 Jan 1;34(6):765-768. doi: 10.21470/1678-9741-2019-0203.

PMID: 31364828 Free PMC Article

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Select item 31120368

 

  1. Toward a characterization of language development in children with congenital heart disease: A pilot study.

Sommariva G, Zilli T, Crescentini C, Marini A, Pilotto C, Venchiarutti M, Gortan AJ, Fabbro F, Cogo P.

Child Neuropsychol. 2020 Jan;26(1):1-14. doi: 10.1080/09297049.2019.1617261. Epub 2019 May 23.

PMID: 31120368

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Select item 31990654

 

  1. Incidence and mortality of brain abscess in Denmark: a nationwide population-based study.

Bodilsen J, Dalager-Pedersen M, van de Beek D, Brouwer MC, Nielsen H.

Clin Microbiol Infect. 2020 Jan;26(1):95-100. doi: 10.1016/j.cmi.2019.05.016. Epub 2019 May 31.

PMID: 31158518

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Select item 31894385

 

  1. Virtual reality in pediatric cardiology: hype or hope for the future?

Sacks LD, Axelrod DM.

Curr Opin Cardiol. 2020 Jan;35(1):37-41. doi: 10.1097/HCO.0000000000000694.

PMID: 31644471

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Select item 31574003

 

  1. Risk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort study.

Parkes B, Hansell AL, Ghosh RE, Douglas P, Fecht D, Wellesley D, Kurinczuk JJ, Rankin J, de Hoogh K, Fuller GW, Elliott P, Toledano MB.

Environ Int. 2020 Jan;134:104845. doi: 10.1016/j.envint.2019.05.039. Epub 2019 Jun 20.

PMID: 31230843 Free Article

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Select item 31329841

 

  1. Magnetic resonance hyperpolarization imaging detects early myocardial dysfunction in a porcine model of right ventricular heart failure.

Agger P, Hyldebrandt JA, Hansen ESS, Omann C, Bøgh N, Waziri F, Nielsen PM, Laustsen C.

Eur Heart J Cardiovasc Imaging. 2020 Jan 1;21(1):93-101. doi: 10.1093/ehjci/jez074.

PMID: 31329841 Free PMC Article

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Select item 31280290

 

  1. Multicentre reference values for cardiac magnetic resonance imaging derived ventricular size and function for children aged 0-18 years.

van der Ven JPG, Sadighy Z, Valsangiacomo Buechel ER, Sarikouch S, Robbers-Visser D, Kellenberger CJ, Kaiser T, Beerbaum P, Boersma E, Helbing WA.

Eur Heart J Cardiovasc Imaging. 2020 Jan 1;21(1):102-113. doi: 10.1093/ehjci/jez164.

PMID: 31280290 Free PMC Article

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Select item 31180449

 

  1. Prospective evaluation of autoimmune and non-autoimmune subclinical hypothyroidism in Down syndrome children.

Pepe G, Corica D, de Sanctis L, Salerno M, Faienza MF, Tessaris D, Tuli G, Scala I, Penta L, Alibrandi A, Pajno GB, Aversa T, Wasniewska M.

Eur J Endocrinol. 2020 Jan 1. pii: EJE-19-0823.R2. doi: 10.1530/EJE-19-0823. [Epub ahead of print]

PMID: 31999620

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Select item 31534214

 

  1. Reproducibility and Intervendor Agreement of Left Ventricular Global Systolic Strain in Children Using a Layer-Specific Analysis.

Ramlogan S, Aly D, France R, Schmidt S, Hinzman J, Sherman A, Goudar SP, Forsha D.

J Am Soc Echocardiogr. 2020 Jan;33(1):110-119. doi: 10.1016/j.echo.2019.08.004. Epub 2019 Oct 23.

PMID: 31668503

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Select item 31979603

 

  1. Update on stem cell technologies in congenital heart disease.

Brown MA, Rajamarthandan S, Francis B, O’Leary-Kelly MK, Sinha P.

J Card Surg. 2020 Jan;35(1):174-179. doi: 10.1111/jocs.14312. Epub 2019 Nov 9. Review.

PMID: 31705822

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Select item 31654591

 

  1. Outcomes for Ectopia Cordis.

Smith BJ, Flyer JN, Edwards EM, Soll RF, Horbar JD, Yeager SB.

J Pediatr. 2020 Jan;216:67-72. doi: 10.1016/j.jpeds.2019.09.014. Epub 2019 Oct 24.

PMID: 31668886

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Select item 31610927

 

  1. Iron Deficiency Is Associated with Adverse Outcomes in Pediatric Heart Failure.

Puri K, Price JF, Spinner JA, Powers JM, Denfield SW, Cabrera AG, Tunuguntla HP, Dreyer WJ, Shah MD.

J Pediatr. 2020 Jan;216:58-66.e1. doi: 10.1016/j.jpeds.2019.08.060. Epub 2019 Oct 11.

PMID: 31610927

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Select item 31669495

 

  1. Risk Factors and Outcomes of Tetralogy of Fallot: From Fetal to Neonatal Life.

Silva JA, Neves AL, Flor-de-Lima F, Soares P, Guimarães H.

Pediatr Cardiol. 2020 Jan;41(1):155-164. doi: 10.1007/s00246-019-02239-4. Epub 2019 Nov 25.

PMID: 31768578

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Select item 31758211

 

  1. Neonatal Non-compacted Cardiomyopathy: Predictors of Poor Outcome.

Rodriguez-Fanjul J, Tubio-Gómez S, Carretero Bellón JM, Bautista-Rodríguez C, Sanchez-de-Toledo J.

Pediatr Cardiol. 2020 Jan;41(1):175-180. doi: 10.1007/s00246-019-02241-w. Epub 2019 Nov 23.

PMID: 31758211

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Select item 31758210

 

  1. Trends in Infant Mortality After TAPVR Repair over 18 Years in Texas and Impact of Hospital Surgical Volume.

Lahiri S, Wang Y, Caldarone CA, Morris SA.

Pediatr Cardiol. 2020 Jan;41(1):77-87. doi: 10.1007/s00246-019-02224-x. Epub 2019 Nov 22.

PMID: 31758210

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Select item 31745583

 

  1. ChyloBEST: Chylothorax in Infants and Nutrition with Low-Fat Breast Milk.

Neumann L, Springer T, Nieschke K, Kostelka M, Dähnert I.

Pediatr Cardiol. 2020 Jan;41(1):108-113. doi: 10.1007/s00246-019-02230-z. Epub 2019 Nov 15.

PMID: 31729543

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Select item 31676955

 

  1. Early Integration of Palliative Care in Families of Children with Single Ventricle Congenital Heart Defects: A Quality Improvement Project to Enhance Family Support.

Davis JAM, Bass A, Humphrey L, Texter K, Garee A.

Pediatr Cardiol. 2020 Jan;41(1):114-122. doi: 10.1007/s00246-019-02231-y. Epub 2019 Nov 1.

PMID: 31676955

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Select item 31673735

 

  1. The Utility of Echocardiography in Pediatric Patients with Structurally Normal Hearts and Suspected Endocarditis.

Kelly P, Hua N, Madriago EJ, Holmes KW, Shaughnessy R, Ronai C.

Pediatr Cardiol. 2020 Jan;41(1):62-68. doi: 10.1007/s00246-019-02222-z. Epub 2019 Oct 31.

PMID: 31673735

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Select item 31654097

 

  1. Border Medicine: The Pediatric Cardiology Perspective.

Agrawal A, Swaminathan S, Guvvala SL, Gorla SR.

Pediatr Cardiol. 2020 Jan;41(1):202-205. doi: 10.1007/s00246-019-02171-7. Epub 2019 Jul 25.

PMID: 31342117

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Select item 31593556

 

  1. Altered 4-D magnetic resonance imaging flow characteristics in complex congenital aortic arch repair.

Desai LP, Berhane H, Husain N, Robinson JD, Rigsby CK, Markl M.

Pediatr Radiol. 2020 Jan;50(1):17-27. doi: 10.1007/s00247-019-04507-0. Epub 2019 Aug 31.

PMID: 31473788

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Select item 31801853

 

  1. Pentalogy of Fallot: A case report and overview dental implications.

Kaushal D, Kalra N, Tyagi R, Khatri A, Biswas K.

Spec Care Dentist. 2020 Jan;40(1):121-126. doi: 10.1111/scd.12433. Epub 2019 Dec 3.

PMID: 31794068

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Select item 31869685

 

  1. Double-Outlet Right Atrium: Review of a Rare Anomaly With an Exemplary Case.

Ambra M, Nuri HA, Giuseppe P, Marasini M, Francesco S.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):79-84. doi: 10.1177/2150135119885895.

PMID: 31835981

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  1. Budesonide for Protein Losing Enteropathy in Patients with Fontan Circulation: A Systematic Review and Meta-Analysis.

Kewcharoen J, Mekraksakit P, Limpruttidham N, Kanitsoraphan C, Charoenpoonsiri N, Poonsombudlert K, Pattison RJ, Rattanawong P.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):85-91. doi: 10.1177/2150135119872196.

PMID: 31835979

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Select item 31835977

 

 

  1. Enzyme replacement therapy in Fabry disease in Poland: a position statement.

Nowicki M, Bazan-Socha S, Błażejewska-Hyzorek B, Gellert R, Imiela J, Kaźmierczak J, Kłopotowski M, Oko-Sarnowska Z, Pawlaczyk K, Ponikowski P, Sławek J, Sykut-Cegielska J, Witkowski A, Zwolińska D.

Pol Arch Intern Med. 2020 Jan 31;130(1):91-97. doi: 10.20452/pamw.15117. Epub 2019 Dec 20. No abstract available.

PMID: 31868861 Free Article

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Select item 32003478

 

  1. Maternal Low Body Mass Index is a Risk Factor for Fetal Ductal Constriction Following Indomethacin use among Women Undergoing Fetal Repair of Spina Bifida.

Nassr AA, Furtun BY, Cortes MS, Erfani H, Whitehead WE, Donado MY, Olutoye O, Velez MP, Espinoza J, Belfort MA, Shamshirsaz AA.

Prenat Diagn. 2020 Jan 31. doi: 10.1002/pd.5655. [Epub ahead of print]

PMID: 32003478

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Select item 31999067

 

  1. Everolimus for cardiac rhabdomyomas in children with tuberous sclerosis. The ORACLE study protocol (everOlimus for caRdiac rhAbdomyomas in tuberous sCLErosis): a randomised, multicentre, placebo-controlled, double-blind phase II trial.

Stelmaszewski EV, Parente DB, Farina A, Stein A, Gutierrez A, Raquelo-Menegassio AF, Manterola C, de Sousa CF, Victor C, Maki D, Morón EM, de Abrantes FF, Iqbal F, Camacho-Vilchez J, Jimenez-Pavón J, Polania JP, Thompson L, Bonanato L, Diebold M, Da Silva MVCP, Nashwan MWJ, Galvani MAG, Idris OEA, Danos P, Ortiz-Lopez R, Mahmoud RAA, Gresse S, Loss KL.

Cardiol Young. 2020 Jan 27:1-9. doi: 10.1017/S1047951119003147. [Epub ahead of print]

PMID: 31983379

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Select item 31983366

 

  1. The Endocardium and Heart Valves.

Dye B, Lincoln J.

Cold Spring Harb Perspect Biol. 2020 Jan 27. pii: a036723. doi: 10.1101/cshperspect.a036723. [Epub ahead of print]

PMID: 31988139

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Select item 31986196

 

  1. Effects of levosimendan on ventriculo-arterial coupling and cardiac efficiency in paediatric patients with single-ventricle physiology after surgical palliation: retrospective study.

Iacobelli R, Ricci Z, Marinari E, Haiberger R, Di Molfetta A, Toscano A, Di Chiara L.

Interact Cardiovasc Thorac Surg. 2020 Jan 27. pii: ivz319. doi: 10.1093/icvts/ivz319. [Epub ahead of print]

PMID: 31986196

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Select item 31990901

 

  1. Noninvasive prognostic biomarkers for left heart failure as predictors of survival in pulmonary arterial hypertension.

Simpson CE, Damico RL, Hassoun PM, Martin LJ, Yang J, Nies MK, Vaidya RD, Brandal S, Pauciulo MW, Austin ED, Ivy DD, Nichols WC, Everett AD.

Chest. 2020 Jan 24. pii: S0012-3692(20)30129-X. doi: 10.1016/j.chest.2019.12.037. [Epub ahead of print]

PMID: 31987881

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Select item 31980953

 

  1. Risk factors associated with progression and persistence of small- and medium-sized coronary artery aneurysms in Kawasaki disease: a prospective cohort study.

Liu L, Luo C, Hua Y, Wu M, Shao S, Liu X, Zhou K, Wang C.

Eur J Pediatr. 2020 Jan 24. doi: 10.1007/s00431-019-03492-8. [Epub ahead of print]

PMID: 31980953

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Select item 31987750

 

  1. Blood Speckle-Tracking Based on High-Frame Rate Ultrasound Imaging in Pediatric Cardiology.

Nyrnes SA, Fadnes S, Wigen MS, Mertens L, Lovstakken L.

J Am Soc Echocardiogr. 2020 Jan 24. pii: S0894-7317(19)31114-9. doi: 10.1016/j.echo.2019.11.003. [Epub ahead of print]

PMID: 31987749

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Select item 31987651

 

  1. Highly accelerated, real-time phase-contrast MRI using radial k-space sampling and GROG-GRASP reconstruction: a feasibility study in pediatric patients with congenital heart disease.

Haji-Valizadeh H, Feng L, Ma LE, Shen D, Block KT, Robinson JD, Markl M, Rigsby CK, Kim D.

NMR Biomed. 2020 Jan 24:e4240. doi: 10.1002/nbm.4240. [Epub ahead of print]

PMID: 31977117

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Select item 31980851

 

  1. Which one predominates in Ebstein anomaly: tricuspid regurgitation or right ventricular dysfunction? (Reply).

Holst KA, Qureshi MY, Dearani JA.

Ann Thorac Surg. 2020 Jan 23. pii: S0003-4975(20)30054-0. doi: 10.1016/j.athoracsur.2019.12.011. [Epub ahead of print] No abstract available.

PMID: 31982442

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Select item 31979324

 

  1. Drug Treatment of Pulmonary Hypertension in Children.

Avitabile CM, Vorhies EE, Ivy DD.

Paediatr Drugs. 2020 Jan 21. doi: 10.1007/s40272-019-00374-2. [Epub ahead of print] Review.

PMID: 31960361

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Select item 31961051

 

  1. Use of a novel antiplatelet agent cangrelor in an infant supported with a ventricular assist device.

Absi M, Sainathan S, Beasley G, Boston U.

Artif Organs. 2020 Jan 19. doi: 10.1111/aor.13613. [Epub ahead of print] No abstract available.

PMID: 31957028

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Select item 27809440

 

  1. Truncus arteriosus with retrograde aortic flow: a unique case.

Solomon MA, Thattaliyath B, Ashwath R.

Cardiol Young. 2020 Jan 14:1-3. doi: 10.1017/S1047951119003275. [Epub ahead of print]

PMID: 31933446

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Select item 31943749

 

  1. The relationship between electrocardiographic data and mortality in children diagnosed with dilated cardiomyopathy.

Türe M, Balık H, Akın A, Bilici M, Nergiz A.

Eur J Pediatr. 2020 Jan 14. doi: 10.1007/s00431-020-03569-9. [Epub ahead of print]

PMID: 31938873

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Select item 31953026

 

  1. Children With Acute Myocarditis Often Have Persistent Subclinical Changes as Revealed by Cardiac Magnetic Resonance.

Małek ŁA, Kamińska H, Barczuk-Falęcka M, Ferreira VM, Wójcicka J, Brzewski M, Werner B.

J Magn Reson Imaging. 2020 Jan 13. doi: 10.1002/jmri.27036. [Epub ahead of print]

PMID: 31930765

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Select item 31928261

 

  1. Unravelling the Pathogenetic Mechanisms in Congenital Aortopathies: Need for an Integrative Translational Approach.

Girdauskas E, Kaemmerer H, von Kodolitsch Y.

J Clin Med. 2020 Jan 11;9(1). pii: E204. doi: 10.3390/jcm9010204.

PMID: 31940858 Free Article

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Select item 32014319

 

  1. Commentary: Yet another Fontan computational study-but this one has clay.

Woods RK, Ginde S.

J Thorac Cardiovasc Surg. 2020 Jan 11. pii: S0022-5223(20)30068-4. doi: 10.1016/j.jtcvs.2019.12.080. [Epub ahead of print] No abstract available.

PMID: 32014319

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Select item 31928325

 

  1. Images of a large fistulous communication between the right ventricle and left anterior descending coronary artery.

Alp H, Elmacı AM, Taşar M.

Cardiol Young. 2020 Jan 10:1-2. doi: 10.1017/S1047951119003305. [Epub ahead of print]

PMID: 31920191

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Select item 31920190

 

  1. Changes in valvular regurgitation in mid-term follow-up of children with first attack acute rheumatic fever: first evaluation after the updated Jones criteria.

Güler M, Laloğlu F, Ceviz N.

Cardiol Young. 2020 Jan 10:1-3. doi: 10.1017/S1047951119003317. [Epub ahead of print]

PMID: 31920190

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Select item 31922335

 

  1. Right ventricular end-systolic remodeling index in the assessment of pediatric pulmonary arterial hypertension. The European Pediatric Pulmonary Vascular Disease Network (EPPVDN).

Koestenberger M, Avian A, Chouvarine P, Gamillscheg A, Cvirn G, Schweintzger S, Kurath-Koller S, Cantinotti M, Hohmann D, Hansmann G.

Pediatr Res. 2020 Jan 10. doi: 10.1038/s41390-020-0748-2. [Epub ahead of print]

PMID: 31923914

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Select item 31916529

 

  1. Efficacy of bubble contrast echocardiography in detecting pulmonary arteriovenous fistulas in children with univentricular heart after total cavopulmonary connection.

Asada D, Morishita Y, Kawai Y, Kajiyama Y, Ikeda K.

Cardiol Young. 2020 Jan 9:1-4. doi: 10.1017/S104795111900324X. [Epub ahead of print]

PMID: 31916529

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Select item 31916527

 

  1. Feasibility, reproducibility and accuracy of electrical velocimetry for cardiac output assessment in congenital heart disease.

Egbe AC, Wajih Ullah M, Afzal A, Banala K, Vojjini R, Najam M, Osman K, Thotamgari S, Hagler DJ.

Int J Cardiol Heart Vasc. 2020 Jan 9;26:100464. doi: 10.1016/j.ijcha.2019.100464. eCollection 2020 Feb.

PMID: 31956694 Free PMC Article

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Select item 31954647

 

 

  1. Imaging Aspects of Pediatric Cardiac Tumors.

Fournier E, Séguéla PE, Sauvestre F, Jalal Z, Thomas J, Iriart X, Bonello B, Thambo JB.

JACC Cardiovasc Imaging. 2020 Jan 9. pii: S1936-878X(19)31050-2. doi: 10.1016/j.jcmg.2019.11.017. [Epub ahead of print] No abstract available.

PMID: 31954647

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Select item 31910934

 

  1. Echocardiographic examination of mitral valve abnormalities in the paediatric population: current practices.

Cantinotti M, Giordano R, Koestenberger M, Voges I, Santoro G, Franchi E, Assanta N, Valverde I, Simpson J, Kutty S.

Cardiol Young. 2020 Jan 8:1-11. doi: 10.1017/S1047951119003196. [Epub ahead of print]

PMID: 31910934

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Select item 31910927

 

  1. Setting the stage for increasing diversity in congenital cardiology: let’s celebrate the 75th anniversary of the Blalock-Thomas-Taussig shunt.

Hagdorn QAJ, Berger RMF.

Cardiol Young. 2020 Jan 8:1-2. doi: 10.1017/S1047951119003081. [Epub ahead of print] No abstract available.

PMID: 31910925

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Select item 31914795

 

  1. Pre-participation screening in young elite athletes: Towards a new algorithm?

Gerling S.

Eur J Prev Cardiol. 2020 Jan 8:2047487319897334. doi: 10.1177/2047487319897334. [Epub ahead of print] No abstract available.

PMID: 31914795

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Select item 31915273

 

  1. Urinary NT-proBNP as a potential noninvasive biomarker for screening of pulmonary hypertension in preterm infants: a pilot study.

Naeem B, Ayub A, Aly AM, Malloy MH, Okorodudu AO, Jain SK.

J Perinatol. 2020 Jan 7. doi: 10.1038/s41372-019-0581-9. [Epub ahead of print]

PMID: 31911650

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Select item 31912176

 

 

  1. Management of Persistent Pulmonary Hypertension After Correction of Congenital Heart Defect with Autologous Marrow-Derived Mononuclear Stem Cell Injection into the Pulmonary Artery: A Pilot Study.

Amoozgar H, Banafi P, Mohammadi H, Edraki MR, Mehdizadegan N, Ajami G, Borzouee M, Keshaarz K, Moradi P, Dehghani E.

Pediatr Cardiol. 2020 Jan 7. doi: 10.1007/s00246-019-02273-2. [Epub ahead of print]

PMID: 31912176

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Select item 31909552

 

  1. Development and Utility of Quality Metrics for Ambulatory Pediatric Cardiology in Kawasaki Disease.

Teitel DF, Newburger JW, Sutton N, Tani LY, Harahsheh AS, Jone PN, Mensch DJ, Cotts T, Davidson A, Dahdah N, Johnson WH Jr, Portman MA.

Clin Pediatr (Phila). 2020 Jan 3:9922819896098. doi: 10.1177/0009922819896098. [Epub ahead of print]

PMID: 31896280

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Select item 31921956

 

  1. Self-reported and Accelerometer-Measured Physical Activity in Children With Cardiomyopathy.

Cunningham C, Spence JC, Stearns JA, Carson V, Kantor PF, Urschel S, Conway J.

J Cardiovasc Nurs. 2020 Jan 3. doi: 10.1097/JCN.0000000000000629. [Epub ahead of print]

PMID: 31904691

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Select item 31910992

 

  1. Proof-of-concept for a non-invasive, portable, and wireless device for cardiovascular monitoring in pediatric patients.

Miller JC, Shepherd J, Rinderknecht D, Cheng AL, Pahlevan NM.

PLoS One. 2020 Jan 3;15(1):e0227145. doi: 10.1371/journal.pone.0227145. eCollection 2020.

PMID: 31899768 Free PMC Article

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  1. The limitation of genetic testing in diagnosing patients suspected for congenital platelet defects.

Blaauwgeers MW, van Asten I, Kruip MJHA, Beckers EAM, Coppens M, Eikenboom J, van Galen KPM, Huisman A, Korporaal SJA, Ploos van Amstel HK, Tamminga RYJ, Urbanus RT, Schutgens REG.

Am J Hematol. 2020 Jan;95(1):E26-E28. doi: 10.1002/ajh.25667. Epub 2019 Nov 13. Review. No abstract available.

PMID: 31659778 Free PMC Article

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  1. Anatomically corrected malposition of great arteries: A nidus for the left ventricular outflow tract obstruction.

Gupta P, Chikkagoudar KN, Koneti NR.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):105-106. doi: 10.4103/apc.APC_160_19. Epub 2019 Nov 22. No abstract available.

PMID: 32030052 Free PMC Article

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  1. Isolated persistence of the fifth aortic arch in an infant presenting with congestive heart failure.

Meliota G, Lombardi M, Zaza P, Tagliente MR, Versacci P, Scalzo G, Vairo U.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):91-94. doi: 10.4103/apc.APC_53_19. Epub 2019 Nov 22.

PMID: 32030044 Free PMC Article

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  1. Complete sternal cleft with tetralogy of Fallot.

Das D, Dutta N, Pandey P, Basu A, Sharma MK, Koley R, Chattopadhyay A.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):81-83. doi: 10.4103/apc.APC_86_19. Epub 2019 Dec 4.

PMID: 32030041 Free PMC Article

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  1. Virtual reality in pediatric cardiology: hype or hope for the future?

Sacks LD, Axelrod DM.

Curr Opin Cardiol. 2020 Jan;35(1):37-41. doi: 10.1097/HCO.0000000000000694.

PMID: 31644471

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  1. Anomalous coronary arteries: what is known and what still remains to be learned?

Molossi S, Sachdeva S.

Curr Opin Cardiol. 2020 Jan;35(1):42-51. doi: 10.1097/HCO.0000000000000696.

PMID: 31633566

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  1. Editorial: A contemporary look at pediatric cardiology in 2020.

Cohen M.

Curr Opin Cardiol. 2020 Jan;35(1):35-36. doi: 10.1097/HCO.0000000000000697. No abstract available.

PMID: 31609733

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  1. Dilated cardiomyopathy in children: moving beyond traditional pharmacologic therapy.

Cohen JA, Almodovar MC.

Curr Opin Cardiol. 2020 Jan;35(1):52-57. doi: 10.1097/HCO.0000000000000692.

PMID: 31574005

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  1. Smartphone interfaced handheld echocardiography for focused assessment of ventricular function and structure in children: A pilot study.

Acheampong B, Parra DA, Aliyu MH, Moon TD, Soslow JH.

Echocardiography. 2020 Jan;37(1):96-103. doi: 10.1111/echo.14575. Epub 2019 Dec 27.

PMID: 31879998

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  1. Double-orifice mitral valve associated and bicuspid aortic valve: forme fruste of Shone’s complex?

Yang LT, Foley TA, Eidem BW, Crestanello JA, Michelena HI.

Eur Heart J Cardiovasc Imaging. 2020 Jan 1;21(1):118. doi: 10.1093/ehjci/jez195. No abstract available.

PMID: 31302682

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  1. Multicentre reference values for cardiac magnetic resonance imaging derived ventricular size and function for children aged 0-18 years.

van der Ven JPG, Sadighy Z, Valsangiacomo Buechel ER, Sarikouch S, Robbers-Visser D, Kellenberger CJ, Kaiser T, Beerbaum P, Boersma E, Helbing WA.

Eur Heart J Cardiovasc Imaging. 2020 Jan 1;21(1):102-113. doi: 10.1093/ehjci/jez164.

PMID: 31280290 Free PMC Article

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  1. Coronary artery assessment in Kawasaki disease with dual-source CT angiography to uncover vascular pathology.

van Stijn-Bringas Dimitriades D, Planken RN, Groenink M, Streekstra GJ, Kuijpers TW, Kuipers IM.

Eur Radiol. 2020 Jan;30(1):432-441. doi: 10.1007/s00330-019-06367-6. Epub 2019 Aug 19.

PMID: 31428828 Free PMC Article

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  1. Association of left ventricular size with regional right ventricular mechanics in Hypoplastic Left Heart Syndrome.

Forsha D, Li L, Joseph N, Kutty S, Friedberg MK.

Int J Cardiol. 2020 Jan 1;298:66-71. doi: 10.1016/j.ijcard.2019.07.090. Epub 2019 Aug 1.

PMID: 31402159

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  1. Right ventricular free wall strain predicts functional capacity in patients with repaired Tetralogy of Fallot.

Arroyo-Rodríguez C, Fritche-Salazar JF, Posada-Martínez EL, Arías-Godínez JA, Ortiz-León XA, Calvillo-Arguelles O, Ruiz-Esparza ME, Sandoval JP, Sierra-Lara D, Araiza-Garaygordobil D, Picano E, Rodríguez-Zanella H.

Int J Cardiovasc Imaging. 2020 Jan 1. doi: 10.1007/s10554-019-01753-z. [Epub ahead of print]

PMID: 31894525

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  1. 4D flow vs. 2D cardiac MRI for the evaluation of pulmonary regurgitation and ventricular volume in repaired tetralogy of Fallot: a retrospective case control study.

Jacobs KG, Chan FP, Cheng JY, Vasanawala SS, Maskatia SA.

Int J Cardiovasc Imaging. 2020 Jan 1. doi: 10.1007/s10554-019-01751-1. [Epub ahead of print]

PMID: 31894524

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  1. Diagnostic performance of CT angiography to detect pulmonary vein stenosis in children.

Barrera CA, Saul D, Rapp JB, Smith CL, White AM, Biko DM, Otero HJ.

Int J Cardiovasc Imaging. 2020 Jan;36(1):141-147. doi: 10.1007/s10554-019-01693-8. Epub 2019 Sep 9.

PMID: 31502067

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  1. An automatic diagnostic system of coronary artery lesions in Kawasaki disease using intravascular optical coherence tomography imaging.

Abdolmanafi A, Cheriet F, Duong L, Ibrahim R, Dahdah N.

J Biophotonics. 2020 Jan;13(1):e201900112. doi: 10.1002/jbio.201900112. Epub 2019 Sep 2.

PMID: 31423740

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  1. Perioperative Right Ventricular Systolic Function Determination in Children With Tetralogy of Fallot.

Meinel K, Noessler N, Koestenberger M.

J Cardiothorac Vasc Anesth. 2020 Jan;34(1):306-307. doi: 10.1053/j.jvca.2019.03.067. Epub 2019 Apr 3. No abstract available.

PMID: 31076312

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  1. Severe Mitral Valve Regurgitation due to Significant Coronary Artery Stenosis in a 14-month-old boy with Williams-Beuren Syndrome.

Hornung A, Sieverding L, Schlensak C, Hofbeck M.

Klin Padiatr. 2020 Jan;232(1):40-42. doi: 10.1055/a-1007-8700. Epub 2019 Oct 29. No abstract available.

PMID: 31663105

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  1. Echocardiographic Diagnosis of Anomalous Single Coronary Artery from the Pulmonary Artery: Use of Bubble Contrast Echocardiography.

Thatte N, Kirakosian M, Kaza A, Friedman K.

Pediatr Cardiol. 2020 Jan;41(1):215-216. doi: 10.1007/s00246-019-02265-2. Epub 2019 Dec 13.

PMID: 31834461

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  1. Correction to: Non-surgical Risk Factors for the Development of Chylothorax in Children after Cardiac Surgery-Does Fluid Matter?

Perry T, Bora K, Bakar A, Meyer DB, Sweberg T.

Pediatr Cardiol. 2020 Jan;41(1):201. doi: 10.1007/s00246-019-02259-0.

PMID: 31796981

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  1. Non-surgical Risk Factors for the Development of Chylothorax in Children after Cardiac Surgery-Does Fluid Matter?

Perry T, Bora K, Bakar A, Meyer DB, Sweberg T.

Pediatr Cardiol. 2020 Jan;41(1):194-200. doi: 10.1007/s00246-019-02255-4. Epub 2019 Nov 12. Erratum in: Pediatr Cardiol. 2019 Dec 3;:.

PMID: 31720782

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  1. Two-Dimensional Strain is more Precise than Conventional Measures of Left Ventricular Systolic Function in Pediatric Patients.

Patel MD, Myers C, Negishi K, Singh GK, Anwar S.

Pediatr Cardiol. 2020 Jan;41(1):186-193. doi: 10.1007/s00246-019-02243-8. Epub 2019 Nov 9.

PMID: 31707490

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  1. Parents of Very Young Children with Congenital Heart Defects Report Good Quality of Life for Their Children and Families Regardless of Defect Severity.

Lee JS, Cinanni N, Di Cristofaro N, Lee S, Dillenburg R, Adamo KB, Mondal T, Barrowman N, Shanmugam G, Timmons BW, Longmuir PW.

Pediatr Cardiol. 2020 Jan;41(1):46-53. doi: 10.1007/s00246-019-02220-1. Epub 2019 Nov 7.

PMID: 31701166

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  1. Left Ventricular Layer-Specific Myocardial Strains in Children with Recovered Primary Dilated Cardiomyopathy: What Lies Beneath the Iceberg?

Maher E, Elshehaby W, El Amrousy D, El Razaky O.

Pediatr Cardiol. 2020 Jan;41(1):101-107. doi: 10.1007/s00246-019-02228-7. Epub 2019 Nov 3.

PMID: 31680221

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  1. Early Integration of Palliative Care in Families of Children with Single Ventricle Congenital Heart Defects: A Quality Improvement Project to Enhance Family Support.

Davis JAM, Bass A, Humphrey L, Texter K, Garee A.

Pediatr Cardiol. 2020 Jan;41(1):114-122. doi: 10.1007/s00246-019-02231-y. Epub 2019 Nov 1.

PMID: 31676955

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  1. The Utility of Echocardiography in Pediatric Patients with Structurally Normal Hearts and Suspected Endocarditis.

Kelly P, Hua N, Madriago EJ, Holmes KW, Shaughnessy R, Ronai C.

Pediatr Cardiol. 2020 Jan;41(1):62-68. doi: 10.1007/s00246-019-02222-z. Epub 2019 Oct 31.

PMID: 31673735

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  1. What is Left Ventricular Strain in Healthy Neonates? A Systematic Review and Meta-analysis.

Khan U, Omdal TR, Matre K, Greve G.

Pediatr Cardiol. 2020 Jan;41(1):1-11. doi: 10.1007/s00246-019-02219-8. Epub 2019 Oct 30. Review.

PMID: 31673733

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  1. Comparison of Semi-Automated Versus Manual Quantitative Right Ventricular Assessment in Hypoplastic Left Heart Syndrome.

Penk J, Mukadam S, Zaidi SJ, Cui V, Metzger R, Roberson DA, Li Y.

Pediatr Cardiol. 2020 Jan;41(1):69-76. doi: 10.1007/s00246-019-02223-y. Epub 2019 Oct 28.

PMID: 31659391

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  1. Orthostatic and Exercise Effects in Children Years After Kawasaki Disease.

Nakamura Y, Hama T, Nakamura Y, Tsukada H, Oda Y, Awa S.

Pediatr Cardiol. 2020 Jan;41(1):24-30. doi: 10.1007/s00246-019-02216-x. Epub 2019 Oct 8.

PMID: 31595326

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  1. Real-world Safety and Effectiveness of Infliximab in Pediatric Patients With Acute Kawasaki Disease: A Postmarketing Surveillance in Japan (SAKURA Study).

Miura M, Kobayashi T, Igarashi T, Hamada H, Iwata N, Sasaki Y, Matsukawa M, Sato N, Kubo H, Takei S.

Pediatr Infect Dis J. 2020 Jan;39(1):41-47. doi: 10.1097/INF.0000000000002503.

PMID: 31815838

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  1. Asymptomatic Balanced Double Aortic Arch Associated With Tetralogy of Fallot.

Haranal M, Abdul Latiff HB, Sivalingam S.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):130-132. doi: 10.1177/2150135119885889.

PMID: 31835984

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  1. An interesting case of aorto-left ventricular tunnel.

Janeel M, Vaidyanathan S, Arvind A, Solomon NA.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):108-110. doi: 10.4103/apc.APC_28_19. Epub 2019 Jul 26. No abstract available.

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  1. Congenital left atrial appendage pseudoaneurysm, cardiomyopathy, and mitral regurgitation.

Barac YD, Quinones Q, Schroder J, Glower DD.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):107-108. doi: 10.4103/apc.APC_10_19. Epub 2019 Jul 17. No abstract available.

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  1. Left pulmonary artery from descending thoracic aorta: Part of spectrum of anomalous aortic origin of pulmonary arteries?

Rajanbabu BB, Andrews DR.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):104. doi: 10.4103/apc.APC_130_19. Epub 2019 Nov 7. No abstract available.

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  1. Author’s reply.

Agati S, Sousa CG, Calvaruso FD, Zanai R, Campanella I, Poli D, Pino AD, Secinaro A, Iorio FS, Raponi M, Anderson RH, Reali S, DeZorzi A, Borro L.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):104-105. doi: 10.4103/apc.APC_149_19. Epub 2020 Jan 9. No abstract available.

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  1. Author’s reply.

Garekar S, Bharati A.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):103. doi: 10.4103/apc.APC_153_19. Epub 2020 Jan 9. No abstract available.

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  1. Virtual dissection: An alternative to surface-rendered virtual three-dimensional cardiac model.

Gupta SK, Anderson RH.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):102-103. doi: 10.4103/apc.APC_127_19. Epub 2019 Dec 4. No abstract available.

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  1. Double drainage of total anomalous pulmonary venous connection: A rare variant of mixed total anomalous pulmonary venous connection.

Krishna MR, Gnanappa GK, Mervis J, Forsey J, Ayer JG, Orr Y.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):100-101. doi: 10.4103/apc.APC_45_19. Epub 2019 Jul 19.

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  1. Circumflex retroesophageal left aortic arch with right ductus arteriosus: A rare complete vascular ring diagnosed on computed tomography angiography.

Pandey NN, Shaw M, Sachdeva S, Gulati GS, Kothari SS.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):98-99. doi: 10.4103/apc.APC_128_19. Epub 2019 Nov 7.

PMID: 32030046 Free PMC Article

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  1. An arcade in the heart: Multimodality imaging.

Babu NS, Vimala LR, Varghese L, George OK.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):95-97. doi: 10.4103/apc.APC_47_19. Epub 2019 Oct 9.

PMID: 32030045 Free PMC Article

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  1. Unusual association of transposition of great arteries with infradiaphragmatic pulmonary venous return.

Scrascia G, Grimaldi AMP, Troise D, Scalzo G.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):75-77. doi: 10.4103/apc.APC_54_19. Epub 2019 Dec 4.

PMID: 32030039 Free PMC Article

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  1. Genetic abnormalities/syndromes significantly impact perioperative outcomes of conotruncal heart defects.

Lahiri S, Gil W, Daria S, Joshua G, Parul J, Redmond B, Elizabeth W.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):38-45. doi: 10.4103/apc.APC_51_19. Epub 2019 Oct 9.

PMID: 32030034 Free PMC Article

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  1. An arcade in the heart: Multimodality imaging.

Babu NS, Vimala LR, Varghese L, George OK.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):95-97. doi: 10.4103/apc.APC_47_19. Epub 2019 Oct 9.

PMID: 32030045 Free PMC Article

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ACHD Featured Articles in association with ISACHD

Adult Congenital Heart Featured Reviews of January 2020 Abstracts provided through collaboration with ISACHD.

Fontan-associated nephropathy: Predictors and outcomes.

Khuong JN, Wilson TG, Grigg LE, Bullock A, Celermajer D, Disney P, Wijesekera VA, Hornung T, Zannino D, Iyengar AJ, d’Udekem Y.

Int J Cardiol. 2020 Jan 10. pii: S0167-5273(19)34728-X. doi: 10.1016/j.ijcard.2020.01.014. [Epub ahead of print]

PMID: 31955974

Take Home Points: 

  • 20% of patients with Fontan circuits have mild to moderate renal dysfunction as per eGFR.
  • Atrio-pulmonary Fontan and the absence of a prior bidirectional were the only predictors of renal dysfunction
  • In this cohort, renal dysfunction did not impact the outcomes of death, cardiac transplantation or Fontan failure.

Commentary from Dr. Blanche Cupido (Cape Town, South Africa), section editor of ACHD Journal Watch:  Although nephropathy is a known complication of a Fontan circuit, not much data is available in contemporary literature on this topic. This study from the Australia and New Zealand Fontan Registry aimed to ascertain the prevalence of nephropathy, identify its predictors and characterize their long term outcomes in young adults with Fontan circuits.

Patients >age 16 with Fontan circuits were included if they had a serum creatinine measurement when between the ages of 16 and 25. Those with primary renal diagnoses, those who underwent Fontan take-downs, received heart transplantation or died before age 16, were excluded. Baseline renal function was assessed by glomerular filtration rate (GFR) as per the Modification of Diet in Renal Disease (MDRD) equation. Renal dysfunction was defined as a GFR < 90ml/kg/min/1.73m2.

The primary end-point for Fontan failure was death, heart transplantation, plastic bronchitis, protein losing enteropathy, Fontan take-down and NYHA III-IV. The secondary outcome was chronic kidney disease – GFR < 90ml/kg/min/1.73m2.

 A total of 328 patients were included. Fifty-two percent were male and the mean age was 26 years. The prevalence of renal dysfunction was 20% (n=67). Most had mild renal dysfunction, though 1% (3 patients) had moderate renal dysfunction with a GFR < 60ml/kg/min/1.73m2.

The following factors were associated with increased renal dysfunction on univariate analysis:

  • Atrio-pulmonary Fontan (AP Fontan) – OR 2.22 (95% CI 1.11-4.30, p=0.024)
  • Absence of prior bidirectional cavo-pulmonary shunt – OR 2.23 (95% CI 1.28-3.98, p=0.005)

This did not hold for multi-variate analysis though.

Two patients in the renal dysfunction group (2%) and 19 (7%) of the non-renal dysfunction group died during follow-up. From Figure 1 below, it is evident that fewer deaths occurred in the renal dysfunction group (2/67 deaths vs  9/261 deaths)

Ten year survival for the renal dysfunction group was 96% compared to 89% in the non-renal dysfunction group. (p=0.1) No independent risk factors for mortality were identified.

Figure 2 below shows that the 10-year freedom from death and transplant for the renal dysfunction and no renal dysfunction groups were 96% and 87% respectively (p=0.05)

 

 

Fontan failure occurred in 12% of patients (n=38) over a 7 year follow-up period. There was no difference in the prevalence of Fontan failure between those with and without renal dysfunction.

Ten year freedom from Fontan failure was 82.5% in the renal dysfunction group and 81% in the no renal dysfunction group (p=0.84) – see figure 3 below. Independent risk factors for Fontan failure were right atrial isomerism and developing >moderate ventricular systolic dysfunction.

 

 

Over an 8 year follow-up period, no significant differences in mean eGFR were found in the group who had renal dysfunction at the outset (eGFR 78 vs 80ml/kg/min/1.73m2, p=0.4). The group with normal renal function initially, did show a decline in eGFR (120 to 108ml/kg/min/1.73m2, p<0.001).

 

 

Inspiratory muscle training did not improve exercise capacity and lung function in adult patients with Fontan circulation: A randomized controlled trial.

Fritz C, Müller J, Oberhoffer R, Ewert P, Hager A.

Int J Cardiol. 2020 Jan 9. pii: S0167-5273(19)33852-5. doi: 10.1016/j.ijcard.2020.01.015. [Epub ahead of print]

PMID: 31992463

 

Take Home Points: 

  • Daily IMT for a 6 month period did not improve exercise and lung capacity and lung volumes in Fontan patients.
  • Daily IMT for 6 months in adult patients with Fontan was associated with an increase in O2 saturation at rest.
  • Larger studies are warranted in order to gain more insight into the mechanisms of exercise training and the Fontan physiology.

Commentary from Dr. Soha Romeih (Aswan, Egypt), section editor of ACHD Journal Watch: 

Background:In Fontan patients, due to the hemodynamic limitations of an absent sub-pulmonic chamber, pulmonary arterial and systemic venous blood flow are strongly affected by modest intrathoracic pressure shifts, since ± 30% of flow in the systemic venous pathway is driven by respiration. In patients with Fontan circulation, blood flow in the IVC is increased during inspiration, enhancing the systemic venous blood return into the lungs considerably.

Young adults with Fontan circulation show respiratory and skeletal muscle weakness, and higher prevalence of respiratory muscle dysfunction, comparable to adults with advanced heart failure.

In a recent study in children with Fontan circulation, daily inspiratory muscle training (IMT) of six weeks improved inspiratory muscle strength and ventilatory efficiency in a cardiopulmonary exercise test (CPET). It is therefore reasonable that an individually adjusted IMT in adult patients with Fontan circulation improves parameters of ventilation and exercise capacity.

The aims of the current study were to investigate the effect of a telephone-supervised, daily inspiratory muscle training for 6 months on exercise capacity and on lung volumes in adult patients with Fontan circulation.

Methods

  1. Study subjects 

42 patients (50% female; 30.5 ± 8.1 years; age 18 to 51 years old) out of 209 eligible patients participated from January 2017 until October 2018.

After baseline assessments (visit 1), consisting of a lung function test (LFT) and a CPET, 42 patients were randomized into either an intervention group (IG, n = 20) or control group (CG, n = 22). The IG started performing a telephone-supervised, daily IMT until six months follow-up (visit 2). The daily intervention was performed with an inspiratory resistive training device (POWER breathe International Ltd., Southam, UK).

Within the first six months after baseline evaluation the CG continued their usual activities and did not get any treatment. At the six months follow-up (visit 2) this group started IMT under the same conditions, including weekly telephone supervision till 12 months re-evaluation (visit 3). To assess the sustainability of the training program, the IG was asked to continue performing IMT without weekly telephonic-supervision until 12 months reevaluation (visit 3). This independent six-months IMT period of the CG was performed from 12 months follow-up until 18 months re-evaluation (visit 4). (Figure 1)

The study consisted of three visits for the IG and four visits for the CG, where a CPET and a LFT were performed, respectively. All tests were implemented by the same experienced sports scientist.

 

  1. Inspiratory muscle training (IMT) 

After baseline evaluation patients were instructed by an experienced sports scientist in term of the IMT. Patients were instructed to begin the inhalation phase with diaphragmatic breathing and to continue inhaling by expanding the rib cage. Incorrect breathing and malposition were corrected immediately. Patients used an inspiratory resistive training device for three sets with 10–30 repetitions once daily. During the second 6 months training period, patients were instructed to continue the IMT independently, since no telephone supervision was implemented. Both groups performed IMT under the same conditions.

 

  1. Measurement of exercise capacity

Incremental symptom-limited CPET until exhaustion. Gas exchange and ventilation were measured via a breath-by-breath gas exchange analysis. Peak oxygen uptake (VO2 peak) was calculated as the highest mean O2 consumption obtained during any 30-second time interval. Compliance criteria for a valid CPET were achieved when either respiratory exchange ratio (RER) was ≥1.05, or peak heart rate was ≥85%. Cyanotic patients (oxygen saturation b 90% at rest or at peak exercise) were rarely able to reach the above-mentioned thresholds, however they were included in the study, independent of those criteria.

 

  1. Measurement of lung function

Forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and the FEV1/FVC ratio were performed.

Results:

  1. Exercise capacity

At 6 months re-evaluation both groups had not improved their VO2 peak and VO2 peak predicted, without any significant difference between IG and CG. Additionally, no significant difference was found between the IG and the CG concerning ventilatory efficiency.

The only significant result was an increase of O2 saturation at rest in the IG in comparison to the CG after six months IMT.  These results indicate an enhancement of hypoxic pulmonary vasoconstriction resulting in an improvement in ventilation/perfusion matching, which favors systemic oxygen delivery by the constriction of intrapulmonary arteries reacting to alveolar hypoxia. Another plausible mechanism could be a reduction in chronic atelectasis following IMT. Hence IMT may improve blood flow of the lungs.

  1. Lung function

After 6 months of IMT, no significant changes could be observed between the IG and the CG concerning FVC and FVC predicted. Further, FEV1 and FEV1 predicted did not change significantly after IMT between the IG and CG.

Conclusions

Six months of weekly telephone-supervised, daily IMT could not improve exercise and lung capacity in adult patients with Fontan circulation. According to current evidence, beneficial effects of IMT in adult patients with Fontan circulation cannot be verified. Therefore, larger studies are warranted in order to gain more insight into the mechanisms of exercise training and the Fontan physiology.

 

 

 

 

Fontan protein-losing enteropathy is associated with advanced liver disease and a proinflammatory intestinal and systemic state.

Rodríguez de Santiago E, Téllez L, Garrido-Lestache Rodríguez-Monte E, Garrido-Gómez E, Aguilera-Castro L, Álvarez-Fuente M, Del Cerro MJ, Albillos A.

Liver Int. 2020 Jan 8. doi: 10.1111/liv.14375. [Epub ahead of print]

PMID: 31912956

Similar articles

Take Home Points: 

  • Fontan patients with PLE demonstrated more severe liver damage and cardiac impairment, and greater systemic inflammation, intestinal inflammation and intestinal permeability than those without PLE.
  • Timely reminder that liver assessment and close surveillance is essential in all Fontan patients, and especially those with PLE.
  • Faecal calprotectin is complementary to faecal alpha-1-antitrypsin and may be useful as a biomarker for the diagnosis and follow-up of Fontan PLE.
  • Data originates from an observational single-centre case-control study (n=29).

Commentary from Dr. Timothy Roberts (Melbourne, Australia), section editor of ACHD Journal Watch:  

Background

Protein-losing enteropathy (PLE) affects 3 – 18 % of patients after a Fontan operation, and is thought to be contributed by factors including elevated central venous pressure and inflammation.

 Aims of this study:  to investigate in patients with Fontan circulation and PLE:

  1. the presence of intestinal and systemic inflammation;
  2. the relationship between PLE and severity of liver and cardiac damage.

 Methods

All Fontan subjects diagnosed prospectively with PLE were included. PLE was defined as a 24 hours alpha-1-antitrypsin faecal clearance value above 27 mL/day. Exclusion criteria were coexisting inflammatory bowel disease, coeliac disease or gastrointestinal infection. Controls were matched at a 1:1 ratio by age (±2 years) and Fontan surgery procedure (atriopulmonary vs total cavopulmonary).

Initial assessment included a structured medical interview, physical examination, blood and faeces tests, abdominal Doppler-ultrasonography, liver elastography, abdominal angio-magnetic resonance imaging (MRI) or computed tomography (CT) scan when MRI was contraindicated, and echocardiography. A cardiac MRI and cardiac haemodynamic study were also performed when clinically indicated.

 

Results

Of 61 subjects, 15 had PLE (24.6 %) with one excluded following diagnosis of coeliac disease. Fifteen control Fontan patients were included (see Figure 1, below).

 

Faecal calprotectin was significantly increased in the PLE group (80 vs 30 ug/g, P < 0.001; Figure 2). Serum I-FABP, used as a marker of intestinal barrier disruption, was elevated in PLE (9 vs 5 ng/ml, P = 0.019), while pro-inflammatory cytokines TNF-alpha and IL-6 were also elevated in the PLE cohort (Figure 3).

 

Cardiac index was lower in PLE subjects in the hemodynamic study (2.54 vs 4.25 L/min/m2, P = .016), lower ventricular ejection fraction on cardiac MRI (58.5% vs 63.5%, P = .04) and lower systemic oxygen saturation (93% vs 96%, P = .025). No difference in BNP was observed.

No difference in routine liver function testing was observed (bilirubin, ALT, AST, GGT, ALP). Platelet count was lower, while liver stiffness was greater (25.4 vs 14.3 kPA; P < 0.001) in the PLE group. No cases of hepatocarcinoma were diagnosed.

 

Conclusions

Fontan patients with PLE demonstrated more severe liver damage and cardiac impairment, and greater systemic inflammation, intestinal inflammation and intestinal permeability than those without PLE.

Faecal calprotectin is complementary to faecal alpha-1-antitrypsin and may be useful as a biomarker for the diagnosis and follow-up of Fontan patients diagnosed with PLE.

 

Assessment and Implications of Right Ventricular Afterload in Tetralogy of Fallot.

Egbe AC, Taggart NW, Reddy YNV, Sufian M, Banala K, Vojjini R, Najam M, Osman K, Obokata M, Borlaug BA.

Am J Cardiol. 2019 Dec 1;124(11):1780-1784. doi: 10.1016/j.amjcard.2019.08.035. Epub 2019 Sep 9.

PMID: 31586531

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Take Home Points:

  • In adult patients with repaired tetralogy of Fallot (TOF), higher right ventricle systolic pressure (RVSP) is associated with worse prognosis including a higher risk of death or transplant. However, there was no such association with right ventricle outflow tract (RVOT) obstruction severity.
  • In this study, there was good correlation between invasively measured and Doppler derived RVSP.

Commentary from Dr. Maan Jokhadar (Atlanta GA), section editor of ACHD Journal Watch: 

Repaired TOF patients commonly have residual RVOT obstruction and increased right ventricle (RV) pressure overload. This is in addition to the increased risk of pulmonary valve regurgitation after repair and right ventricle volume overload.

Dr. Egbe and colleagues from Mayo Clinic in Rochester, Minnesota performed a retrospective cohort analysis of 266 adult TOF patients who had contemporaneous echocardiography and cardiac catheterization (within 48 hours) between 1990 and 2015. Patients with aortopulmonary collaterals were excluded. The mean age was about 35 and the mean follow-up with just under 13 years.

In this study, invasively measured RVSP was used as an index of RV afterload, which can increase as a result of any number of factors that include RVOT obstruction, pulmonary artery vascular obstruction, pulmonary vascular resistance, and increased left heart filling pressure.

Study participants were divided into 2 groups based on RVOT gradient of less or more than 36 mmHg.  About 66% (175 patients) had significant RVOT obstruction and the rest did not.   During a follow-up period of almost 13 years, there was no significant mortality difference between patients with and without RVOT obstruction: 27/175 patients died in the RVOT obstruction group and 8/91 patients died in the no RVOT obstruction group.

Of the 35 patients who died, right heart failure was the cause in 14, sudden-death in 11, sepsis with multi organ system failure in 3, postoperative death in 4, major bleeding in 2, and 1 died of unknown causes. There were 4 patients who had heart transplant.

In this study, there was good correlation between invasively measured and Doppler derived RVSP.

In adult repaired TOF patients, higher RVSP, as a marker of RV afterload, was independently associated with death and heart transplant, whether assessed invasively or non-invasively. However, there was no such association with RVOT obstruction. Thus, increased RV pressure overload from any cause is a marker of worse prognosis in repaired TOF patients. Further study is needed to determine if reducing RV pressure overload improved outcomes.

The results of the study bolster the notion that elevated RVSP is helpful in the risk stratification and decision-making regarding pulmonary valve intervention for patients with repaired TOF and pulmonary regurgitation. However, further study is needed.

ACHD Jan 2020

 

  1. Prevalence, Risk Factors, and Impact of Obstructive Sleep Apnea in Adults with Congenital Heart Disease.

Drake M, Ginde S, Cohen S, Bartz P, Sowinski J, Reinhardt E, Saleska T, Earing MG.

Pediatr Cardiol. 2020 Jan 30. doi: 10.1007/s00246-020-02289-z. [Epub ahead of print]

PMID: 32002577

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Chilikov A, Wainstock T, Sheiner E, Pariente G.

Eur J Obstet Gynecol Reprod Biol. 2020 Jan 29;246:145-150. doi: 10.1016/j.ejogrb.2020.01.038. [Epub ahead of print]

PMID: 32028141

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Ly R, Compain F, Gaye B, Pontnau F, Bouchard M, Mainardi JL, Iserin L, Lebeaux D, Ladouceur M.

Eur Heart J Acute Cardiovasc Care. 2020 Jan 28:2048872620901394. doi: 10.1177/2048872620901394. [Epub ahead of print]

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  1. Creating a Multidisciplinary Pregnancy Heart Team.

Easter SR, Valente AM, Economy KE.

Curr Treat Options Cardiovasc Med. 2020 Jan 27;22(1):3. doi: 10.1007/s11936-020-0800-x. Review.

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  1. Exploring the lived experiences of pregnancy and early motherhood in Italian women with congenital heart disease: an interpretative phenomenological analysis.

Flocco SF, Caruso R, Barello S, Nania T, Simeone S, Dellafiore F.

BMJ Open. 2020 Jan 23;10(1):e034588. doi: 10.1136/bmjopen-2019-034588.

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  1. Assessment and management of heart failure in the systemic right ventricle.

Carazo M, Andrade L, Kim Y, Wilson W, Wu FM.

Heart Fail Rev. 2020 Jan 22. doi: 10.1007/s10741-020-09914-2. [Epub ahead of print] Review.

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  1. 4D Flow MRI hemodynamic benchmarking of surgical bioprosthetic valves.

Sturla F, Piatti F, Jaworek M, Lucherini F, Pluchinotta FR, Siryk SV, Giese D, Vismara R, Tasca G, Menicanti L, Redaelli A, Lombardi M.

Magn Reson Imaging. 2020 Jan 22;68:18-29. doi: 10.1016/j.mri.2020.01.006. [Epub ahead of print]

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  1. Contraceptive methods of privately insured US women with congenital heart defects.

Anderson KN, Tepper NK, Downing K, Ailes EC, Abarbanell G, Farr SL.

Am Heart J. 2020 Jan 21;222:38-45. doi: 10.1016/j.ahj.2020.01.008. [Epub ahead of print]

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Duijnhouwer A, van den Hoven A, Merkx R, Schokking M, van Kimmenade R, Kempers M, Dijk AV, de Boer MJ, Roos-Hesselink J.

J Clin Med. 2020 Jan 21;9(2). pii: E290. doi: 10.3390/jcm9020290.

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  1. Employment Status and Contributing Factors among Adult with Congenital Heart Disease in Japan.

Enomoto J, Mizuno Y, Okajima Y, Kawasoe Y, Morishima H, Tateno S.

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Skogby S, Moons P, Johansson B, Sunnegårdh J, Christersson C, Nagy E, Winberg P, Hanséus K, Trzebiatowska-Krzynska A, Fadl S, Fernlund E, Kazamia K, Rydberg A, Zühlke L, Goossens E, Bratt EL.

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Nashat H, Kempny A, Harries C, Dormand N, Alonso-Gonzalez R, Price LC, Gatzoulis MA, Dimopoulos K, Wort SJ.

Int J Cardiol. 2020 Jan 15;299:131-135. doi: 10.1016/j.ijcard.2019.07.004. Epub 2019 Jul 4.

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Possner M, Buechel RR, Vontobel J, Mikulicic F, Gräni C, Benz DC, Clerc OF, Fuchs TA, Tobler D, Stambach D, Greutmann M, Kaufmann PA.

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Yang H, Bouma BJ, Dimopoulos K, Khairy P, Ladouceur M, Niwa K, Greutmann M, Schwerzmann M, Egbe A, Scognamiglio G, Budts W, Veldtman G, Opotowsky AR, Broberg CS, Gumbiene L, Meijboom FJ, Rutz T, Post MC, Moe T, Lipczyńska M, Tsai SF, Chakrabarti S, Tobler D, Davidson W, Morissens M, van Dijk A, Buber J, Bouchardy J, Skoglund K, Christersson C, Kronvall T, Konings TC, Alonso-Gonzalez R, Mizuno A, Webb G, Laukyte M, Sieswerda GTJ, Shafer K, Aboulhosn J, Mulder BJM.

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Easson K, Rohlicek CV, Houde JC, Gilbert G, Saint-Martin C, Fontes K, Majnemer A, Marelli A, Wintermark P, Descoteaux M, Brossard-Racine M.

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Radin M, Schreiber K, Cecchi I, Bortoluzzi A, Crisafulli F, de Freitas CM, Bacco B, Rubini E, Foddai SG, Padovan M, Gallo Cassarino S, Franceschini F, Andrade D, Benedetto C, Govoni M, Bertero T, Marozio L, Roccatello D, Andreoli L, Sciascia S.

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Ooues G, Pope N, Hudsmith LE.

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Kubota H, Endo H, Ishii H, Tsuchiya H, Inaba Y, Terakawa K, Takahashi Y, Noma M, Takemoto K, Taniai S, Sakata K, Soejima K, Shimoyamada H, Kamma H, Kawakami H, Kaneko Y, Hirono S, Izumi D, Ozaki K, Minamino T, Yoshino H, Sudo K.

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  1. Heart failure in adult congenital heart disease: tetralogy of Fallot.

Mueller AS, McDonald DM, Singh HS, Ginns JN.

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Khuong JN, Wilson TG, Grigg LE, Bullock A, Celermajer D, Disney P, Wijesekera VA, Hornung T, Zannino D, Iyengar AJ, d’Udekem Y.

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Farr SL, Klewer SE, Nembhard WN, Alter C, Downing KF, Andrews JG, Collins RT, Glidewell J, Benavides A, Goudie A, Riehle-Colarusso T, Overman L, Riser AP, Oster ME.

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  1. Left ventricular non-compaction in patients with single ventricle heart disease.

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  1. Inspiratory muscle training did not improve exercise capacity and lung function in adult patients with Fontan circulation: A randomized controlled trial.

Fritz C, Müller J, Oberhoffer R, Ewert P, Hager A.

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  1. ACC/AHA/ASE/HRS/ISACHD/SCAI/SCCT/SCMR/SOPE 2020 Appropriate Use Criteria for Multimodality Imaging During the Follow-Up Care of Patients With Congenital Heart Disease: A Report of the American College of Cardiology Solution Set Oversight Committee and Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, Heart Rhythm Society, International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Pediatric Echocardiography.

Writing Group, Sachdeva R, Valente AM, Armstrong AK, Cook SC, Han BK, Lopez L, Lui GK, Pickard SS, Powell AJ; Rating Panel, Bhave NM, Sachdeva R, Valente AM, Pickard SS, Baffa JM, Banka P, Cohen SB, Glickstein JS, Kanter JP, Kanter RJ, Kim YY, Kipps AK, Latson LA, Lin JP, Parra DA, Rodriguez FH 3rd, Saarel EV, Srivastava S, Stephenson EA, Stout KK, Zaidi AN.

J Am Coll Cardiol. 2020 Jan 6. pii: S0735-1097(19)37812-X. doi: 10.1016/j.jacc.2019.10.002. [Epub ahead of print] No abstract available.

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  1. Screening and evaluation of newly diagnosed cardiovascular diseases in first-trimester asymptomatic pregnant women in a tertiary antenatal care center in Turkey.

Bozkaya VÖ, Oskovi Kaplan ZA, Özgü E, Engin Ustun Y.

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Gangakhedkar GR, Chhabria RD, Gour SD, Palani Y.

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Shapero KS, Desai NR, Elder RW, Lipkind HS, Chou JC, Spatz ES.

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  1. Large Unrepaired Aortopulmonary Window Presenting in Adulthood.

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  1. Abnormal aortic flow profiles persist after aortic valve replacement in the majority of patients with aortic valve disease: how model-based personalized therapy planning could improve results. A pilot study approach.

Nordmeyer S, Hellmeier F, Yevtushenko P, Kelm M, Lee CB, Lehmann D, Kropf S, Berger F, Falk V, Knosalla C, Kuehne T, Goubergrits L.

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  1. Propensity weighting: how to minimise comparative bias in non-randomised studies?

Moons P.

Eur J Cardiovasc Nurs. 2020 Jan;19(1):83-88. doi: 10.1177/1474515119888972.

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  1. A genetic model for multimorbidity in young adults.

Malecki SL, Van Mil S, Graffi J, Breetvelt E, Corral M, Boot E, Chow EWC, Sanches M, Verma AA, Bassett AS.

Genet Med. 2020 Jan;22(1):132-141. doi: 10.1038/s41436-019-0603-1. Epub 2019 Jul 31.

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  1. Medical therapy for heart failure in adult congenital heart disease: does it work?

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  1. Management of the adult Fontan patient.

Rodriguez FH, Book WM.

Heart. 2020 Jan;106(2):105-110. doi: 10.1136/heartjnl-2019-314937. Epub 2019 Oct 29. Review.

PMID: 31662332

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Select item 31649049

 

  1. Heart-lung transplantation in Eisenmenger syndrome (two for the price of ?).

Bhatt AB, Krishnamurthy Y.

Heart. 2020 Jan;106(2):94-96. doi: 10.1136/heartjnl-2019-315780. Epub 2019 Oct 24. No abstract available.

PMID: 31649049

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Select item 31492700

 

  1. Flying the nest: are we doing enough to achieve successful transition in young people with congenital heart disease?

Reekie J.

Heart. 2020 Jan;106(1):87-88. doi: 10.1136/heartjnl-2019-315727. Epub 2019 Sep 6. No abstract available.

PMID: 31492700

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Select item 31735307

 

  1. Body composition changes assessment by bioelectrical impedance vectorial analysis in right heart failure and left heart failure.

González-Islas D, Arámbula-Garza E, Orea-Tejeda A, Castillo-Martínez L, Keirns-Davies C, Salgado-Fernández F, Hernández-Urquieta L, Hernández-López S, Pilotzi-Montiel Y.

Heart Lung. 2020 Jan – Feb;49(1):42-47. doi: 10.1016/j.hrtlng.2019.07.003. Epub 2019 Aug 15.

PMID: 31421949

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Select item 31735685

 

  1. Management of People With a Fontan Circulation: a Cardiac Society of Australia and New Zealand Position statement.

Zentner D, Celermajer DS, Gentles T, d’Udekem Y, Ayer J, Blue GM, Bridgman C, Burchill L, Cheung M, Cordina R, Culnane E, Davis A, du Plessis K, Eagleson K, Finucane K, Frank B, Greenway S, Grigg L, Hardikar W, Hornung T, Hynson J, Iyengar AJ, James P, Justo R, Kalman J, Kasparian N, Le B, Marshall K, Mathew J, McGiffin D, McGuire M, Monagle P, Moore B, Neilsen J, O’Connor B, O’Donnell C, Pflaumer A, Rice K, Sholler G, Skinner JR, Sood S, Ward J, Weintraub R, Wilson T, Wilson W, Winlaw D, Wood A.

Heart Lung Circ. 2020 Jan;29(1):5-39. doi: 10.1016/j.hlc.2019.09.010. Epub 2019 Nov 15.

PMID: 31735685 Free Article

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Select item 30686641

 

  1. Sacubitril/Valsartan in Adult Congenital Heart Disease Patients With Chronic Heart Failure – A Single Centre Case Series and Call for an International Registry.

Appadurai V, Thoreau J, Malpas T, Nicolae M.

Heart Lung Circ. 2020 Jan;29(1):137-141. doi: 10.1016/j.hlc.2018.12.003. Epub 2018 Dec 17.

PMID: 30686641

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Select item 31415819

 

  1. Right ventricular free wall strain predicts functional capacity in patients with repaired Tetralogy of Fallot.

Arroyo-Rodríguez C, Fritche-Salazar JF, Posada-Martínez EL, Arías-Godínez JA, Ortiz-León XA, Calvillo-Arguelles O, Ruiz-Esparza ME, Sandoval JP, Sierra-Lara D, Araiza-Garaygordobil D, Picano E, Rodríguez-Zanella H.

Int J Cardiovasc Imaging. 2020 Jan 1. doi: 10.1007/s10554-019-01753-z. [Epub ahead of print]

PMID: 31894525

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Select item 31894524

 

  1. 4D flow vs. 2D cardiac MRI for the evaluation of pulmonary regurgitation and ventricular volume in repaired tetralogy of Fallot: a retrospective case control study.

Jacobs KG, Chan FP, Cheng JY, Vasanawala SS, Maskatia SA.

Int J Cardiovasc Imaging. 2020 Jan 1. doi: 10.1007/s10554-019-01751-1. [Epub ahead of print]

PMID: 31894524

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Select item 31471763

 

  1. Clinical impact of cardiac computed tomography derived three-dimensional strain for adult congenital heart disease: a pilot study.

Shiina Y, Inai K, Takahashi T, Shimomiya Y, Nagao M.

Int J Cardiovasc Imaging. 2020 Jan;36(1):131-140. doi: 10.1007/s10554-019-01691-w. Epub 2019 Aug 30.

PMID: 31471763

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Select item 31746147

 

  1. Isolated peripheral pulmonary stenosis in Takayasu arteritis.

Alizadehasl A, Saedi S, Ganji H, Pourafkari L.

Int J Rheum Dis. 2020 Jan;23(1):116-119. doi: 10.1111/1756-185X.13742. Epub 2019 Nov 19.

PMID: 31746147

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Select item 31605480

 

  1. A Rare Case of Congenital Heart Disease- Congenitally Corrected Transposition of Great Arteries (CC-TGA) with Infective Endocarditis and Stroke.

Harshini, Padmanaban UB, Raja AG, Panneerselvam AJ.

J Assoc Physicians India. 2020 Jan;68(1):55. No abstract available.

PMID: 31979603

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Select item 31730717

 

  1. Impact of facilities accredited by both adult and pediatric cardiology societies on the outcome of patients with adult congenital heart disease.

Mizuno A, Niwa K, Ochiai R, Shiraishi I, Sumita Y, Daida H, Fukuda T, Miyamoto Y, Nishimura K, Ogawa H, Yasuda S.

J Cardiol. 2020 Jan;75(1):105-109. doi: 10.1016/j.jjcc.2019.06.010. Epub 2019 Aug 14.

PMID: 31421934

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Select item 31868841

 

  1. Cardiac Rehabilitation for Adults and Adolescents With Congenital Heart Disease: EXTENDING BEYOND THE TYPICAL PATIENT POPULATION.

Sarno LA, Misra A, Siddeek H, Kheiwa A, Kobayashi D.

J Cardiopulm Rehabil Prev. 2020 Jan;40(1):E1-E4. doi: 10.1097/HCR.0000000000000482.

PMID: 31868841

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Select item 31805616

 

  1. Never Too Old for a Congenital Heart Disease: A Case of a Unileaflet Mitral Valve in a 76-year-old Man.

Salem A, Zachou G, Makuloluwa K, Kardos A.

J Cardiovasc Imaging. 2020 Jan;28(1):70-73. doi: 10.4250/jcvi.2019.0077. Epub 2019 Sep 24. No abstract available.

PMID: 31805616 Free Article

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Select item 31592855

 

  1. Parent Perspectives on Family-Based Psychosocial Interventions for Congenital Heart Disease.

Gramszlo C, Karpyn A, Demianczyk AC, Shillingford A, Riegel E, Kazak AE, Sood E.

J Pediatr. 2020 Jan;216:51-57.e2. doi: 10.1016/j.jpeds.2019.09.059. Epub 2019 Nov 14.

PMID: 31735417

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Select item 31668886

 

  1. Empowering Young Persons with Congenital Heart Disease: Using Intervention Mapping to Develop a Transition Program – The STEPSTONES Project.

Acuña Mora M, Saarijärvi M, Sparud-Lundin C, Moons P, Bratt EL.

J Pediatr Nurs. 2020 Jan – Feb;50:e8-e17. doi: 10.1016/j.pedn.2019.09.021. Epub 2019 Oct 25.

PMID: 31669495 Free Article

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Select item 30928310

 

 

  1. Potential Value of Native T1 Mapping in Symptomatic Adults with Congenital Heart Disease: A Preliminary Study of 3.0 Tesla Cardiac Magnetic Resonance Imaging.

Shiina Y, Inai K, Taniguchi K, Takahashi T, Nagao M.

Pediatr Cardiol. 2020 Jan;41(1):94-100. doi: 10.1007/s00246-019-02227-8. Epub 2019 Oct 25.

PMID: 31654097

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Select item 31342117

 

  1. Remarkably Still Repairable Large Aortopulmonary Window in an Adult Patient.

Zografos PM, Protopapas EM, Hakim NI, Alexopoulos C, Sarris GE.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):117-119. doi: 10.1177/2150135119878703. Epub 2019 Nov 22.

PMID: 31755375

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  1. Exercise Performance at Increased Altitude After Fontan Operation: Comparison to Normal Controls and Correlation with Cavopulmonary Hemodynamics.

Di Maria MV, Patel SS, Fernie JC, Rausch CM.

Pediatr Cardiol. 2020 Jan 31. doi: 10.1007/s00246-020-02311-4. [Epub ahead of print]

PMID: 32006081

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  1. Prevalence, Risk Factors, and Impact of Obstructive Sleep Apnea in Adults with Congenital Heart Disease.

Drake M, Ginde S, Cohen S, Bartz P, Sowinski J, Reinhardt E, Saleska T, Earing MG.

Pediatr Cardiol. 2020 Jan 30. doi: 10.1007/s00246-020-02289-z. [Epub ahead of print]

PMID: 32002577

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Select item 31997085

 

  1. The accuracy of central blood pressure obtained by oscillometric noninvasive method using Mobil-O-Graph in children and adolescents.

Shiraishi M, Murakami T, Higashi K.

J Hypertens. 2020 Jan 27. doi: 10.1097/HJH.0000000000002360. [Epub ahead of print]

PMID: 31990901

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Select item 31985140

 

  1. Heart rate response during exercise predicts exercise tolerance in adults with transposition of the great arteries and atrial switch operation.

Iriart X, Le Quellenec S, Pillois X, Jaussaud J, Jalal Z, Roubertie F, Douard H, Cochet H, Thambo JB.

Int J Cardiol. 2020 Jan 15;299:116-122. doi: 10.1016/j.ijcard.2019.07.054. Epub 2019 Aug 6.

PMID: 31405586

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Select item 31337551

 

  1. Myocardial blood flow and cardiac sympathetic innervation in young adults late after arterial switch operation for transposition of the great arteries.

Possner M, Buechel RR, Vontobel J, Mikulicic F, Gräni C, Benz DC, Clerc OF, Fuchs TA, Tobler D, Stambach D, Greutmann M, Kaufmann PA.

Int J Cardiol. 2020 Jan 15;299:110-115. doi: 10.1016/j.ijcard.2019.07.041. Epub 2019 Jul 13.

PMID: 31337551

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Select item 31605826

 

 

  1. Acute impact of an endurance race on cardiac function and biomarkers of myocardial injury in triathletes with and without myocardial fibrosis.

Tahir E, Scherz B, Starekova J, Muellerleile K, Fischer R, Schoennagel B, Warncke M, Stehning C, Cavus E, Bohnen S, Radunski UK, Blankenberg S, Simon P, Pressler A, Adam G, Patten M, Lund GK.

Eur J Prev Cardiol. 2020 Jan;27(1):94-104. doi: 10.1177/2047487319859975. Epub 2019 Jun 26.

PMID: 31242053 Free PMC Article

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Select item 31428828

 

  1. Clinical impact of cardiac computed tomography derived three-dimensional strain for adult congenital heart disease: a pilot study.

Shiina Y, Inai K, Takahashi T, Shimomiya Y, Nagao M.

Int J Cardiovasc Imaging. 2020 Jan;36(1):131-140. doi: 10.1007/s10554-019-01691-w. Epub 2019 Aug 30.

PMID: 31471763

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Select item 31927802

 

  1. Cardiac Rehabilitation for Adults and Adolescents With Congenital Heart Disease: EXTENDING BEYOND THE TYPICAL PATIENT POPULATION.

Sarno LA, Misra A, Siddeek H, Kheiwa A, Kobayashi D.

J Cardiopulm Rehabil Prev. 2020 Jan;40(1):E1-E4. doi: 10.1097/HCR.0000000000000482.

PMID: 31868841

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Select item 31076312

 

  1. Listen to the Heart – Rare Cardiac Tumor in an Adolescent.

Noessler N, Schweintzger S, Koestenberger M, Kurath-Koller S.

Klin Padiatr. 2020 Jan;232(1):43. doi: 10.1055/a-1047-0503. Epub 2019 Nov 26. No abstract available.

PMID: 31770781

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Select item 31663105

 

  1. Potential Value of Native T1 Mapping in Symptomatic Adults with Congenital Heart Disease: A Preliminary Study of 3.0 Tesla Cardiac Magnetic Resonance Imaging.

Shiina Y, Inai K, Taniguchi K, Takahashi T, Nagao M.

Pediatr Cardiol. 2020 Jan;41(1):94-100. doi: 10.1007/s00246-019-02227-8. Epub 2019 Oct 25.

PMID: 31654097

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Select item 31654096

 

  1. Reduced brain mammillary body volumes and memory deficits in adolescents who have undergone the Fontan procedure.

Cabrera-Mino C, Roy B, Woo MA, Singh S, Moye S, Halnon NJ, Lewis AB, Kumar R, Pike NA.

Pediatr Res. 2020 Jan;87(1):169-175. doi: 10.1038/s41390-019-0569-3. Epub 2019 Sep 9.

PMID: 31499515

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Select item 31401646

 

  1. Assessment of left ventricular myocardial work in Turner syndrome patients: insights from the novel non-invasive pressure-strain loop analysis method.

Oberhoffer FS, Abdul-Khaliq H, Jung AM, Zemlin M, Rohrer TR, Abd El Rahman M.

Quant Imaging Med Surg. 2020 Jan;10(1):15-25. doi: 10.21037/qims.2019.09.19.

PMID: 31956525 Free PMC Article

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  1. Mystery still unresolved: Untouched “Blue heart” presenting at 40yrs of age.

Naganur SH, Tiwari A, Pruthvi CR.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):72-74. doi: 10.4103/apc.APC_149_18. Epub 2019 Dec 4.

PMID: 32030038 Free PMC Article

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Congenital Heart and Pediatric Cardiac Electrophysiology Featured Articles

Congenital Heart and Pediatric Cardiac Featured EP Manuscripts of January 2020

Examination of pathological features of the right atrioventricular groove in hearts with Ebstein’s anomaly, and correlation with arrhythmias.

Marcondes L, Sanders SP, Del Nido PJ, Walsh EP.

Heart Rhythm. 2020 Jan 21. pii: S1547-5271(20)30026-6. doi: 10.1016/j.hrthm.2020.01.013. [Epub ahead of print]

PMID: 31978592

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Select item 31972995

 

Take Home Points:

 

  • Cardiac anatomy in Ebstein’s anomaly (EA) is frequently characterized by a prominent muscular ridge along the inferior AV annulus
  • The presence of this ridge in postmortem hearts correlates with a clinical history of supraventricular tachycardia
  • The presence of an inferior annular ridge has important implications for the pathogenesis of accessory pathways in EA and may affect catheter ablation outcomes

  

Commentary by Dr. Jeremy Moore (Los Angeles) Congenital and Pediatric Cardiac EP section editor:  Marcondes and colleagues report on the pathological features of the right AV groove in hearts with EA and correlate it with clinical evidence of arrhythmia. The study points to a prominent inferior annular ridge in many gross specimens with EA and correlates this anatomical finding with the clinical presence of accessory pathways. The authors were able to identify thirty-three cardiac specimens with EA from their insitutional cardiac registry for morphometric analysis. At blinded gross examination, a prominent ridge was identified along the inferior AV annulus in nearly half of the specimens. In addition, when correlated with a clinical history of definite or suspected arrhythmia, the ridge was identified in 7 of 10 patients with arrhythmia versus only 3 of 14 patients without arrhythmia (70% vs 21%, p=0.03).

 

 

 

 

 

 

 

Due to the quality of the specimens that were up to 60 years old in some cases, the results of microscopic examination in this study were limited. Although accessory muscular connections were suspected by gross examination in 17 cases, this could not be verified by light microscopy. Therefore, a direct correlation between anatomic accessory connections and the presence of a fibromuscular inferior ridge could not be established in the present investigation. As the authors point out however, in the modern era, intact specimens have become a relatively rare commodity as operative outcomes have improved and surgical repair along the true tricuspid annulus is more commonly pursued.

Despite these limitations, the current study contributes greatly to our understanding of the relevant anatomy for catheter ablation of accessory connections in EA. Not only should the usual impedements to successful catheter ablation (i.e. multiple accessory connections, atrial enlargement, displaced AV system conduction, diseased atrial and ventricular myocardium) be expected, but the presence of a prominent annular ridge should be routinely anticipated. The present report also opens the door to future investigations of practical implications of the study findings. For instance, it is possible that the presence of an annular ridge may correlate with specific electrogram characteristics, broad insertions, or multiple accessory connections as often observed in EA. Specific strategies to improve outcomes, such as utilization of intracardiac echocardiography (as the authors suggest) or alternatively, use of pre-procedural advanced imaging with electroanatomical mapping data, could be routinely considered to facilitate technical success for EA. Finally, coronary angiography could be considered standard practice when the operator encounters an annular ridge eithe pre- or intra-procedurally to avoid collateral damage. Ultimately, this study may raise as many questions as it answers, but it represents a major step forward in our understanding of the anatomical correlates of electrophysiology in EA.

 

CHD EP Jan 2020

 

  1. mAdverse Event Rate during Inpatient Sotalol Initiation for the Management of Supraventricular and Ventricular Tachycardia in the Pediatric and Young Adult Population.

Chandler SF, Chu E, Whitehill RD, Bevilacqua LM, Bezzerides VJ, DeWitt ES, Alexander ME, Abrams DJ, Triedman JK, Walsh EP, Mah DY.

Heart Rhythm. 2020 Jan 31. pii: S1547-5271(20)30074-6. doi: 10.1016/j.hrthm.2020.01.022. [Epub ahead of print]

PMID: 32014568

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Select item 31956137

 

  1. Successful Ablation of Atrial Tachycardia Originating from Inside the Single Atrium and Conduit After a Fontan Operation.

Mori H, Sumitomo N, Muraji S, Imamura T, Iwashita N, Kobayashi T.

Int Heart J. 2020 Jan 31;61(1):174-177. doi: 10.1536/ihj.19-236. Epub 2020 Jan 17.

PMID: 31956137 Free Article

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  1. Outcome of ACHD patients with non-inducible versus inducible IART undergoing cavo-tricuspid isthmus ablation: the role of empiric ablation.

Sawhney V, Mc Lellan A, Chatha S, Perera D, Aderonke A, Juno S, Whittaker-Axon S, Daw H, Garcia J, Lambiase PD, Cullen S, Bhan A, Von Klemperer K, Walker F, Pandya B, Lowe MD, Ezzat V.

J Interv Card Electrophysiol. 2020 Jan 29. doi: 10.1007/s10840-019-00692-y. [Epub ahead of print]

PMID: 31997041

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Select item 31994447

 

  1. Examination of pathological features of the right atrioventricular groove in hearts with Ebstein’s anomaly, and correlation with arrhythmias.

Marcondes L, Sanders SP, Del Nido PJ, Walsh EP.

Heart Rhythm. 2020 Jan 21. pii: S1547-5271(20)30026-6. doi: 10.1016/j.hrthm.2020.01.013. [Epub ahead of print]

PMID: 31978592

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  1. An International Multi-Center Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.

Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazzolini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ.

Circulation. 2020 Jan 16. doi: 10.1161/CIRCULATIONAHA.119.043114. [Epub ahead of print]

PMID: 31941373

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  1. Pacing in Patients with Congenital Heart Disease: When Is It Helpful and When Is It Harmful?

Weiland MD, Spector Z, Idriss SF.

Curr Cardiol Rep. 2020 Jan 16;22(1):5. doi: 10.1007/s11886-020-1253-2. Review.

PMID: 31950297

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Select item 31982163

 

  1. Arrhythmia and advanced heart failure in complex congenital heart diseases: What should we do?

Ladouceur M.

Int J Cardiol. 2020 Jan 13. pii: S0167-5273(19)36087-5. doi: 10.1016/j.ijcard.2020.01.022. [Epub ahead of print] No abstract available.

PMID: 31959409

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Select item 31931842

 

  1. High density mapping and catheter ablation of atrial tachycardias in adults with congenital heart disease.

Krause U, Müller MJ, Stellmacher C, Backhoff D, Schneider H, Paul T.

Clin Res Cardiol. 2020 Jan 2. doi: 10.1007/s00392-019-01592-x. [Epub ahead of print]

PMID: 31897601

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Select item 31902564

 

  1. Long-term follow-up of implantable cardioverter-defibrillators in children: Indications and outcomes.

Kwiatkowska J, Budrejko S, Wasicionek M, Meyer-Szary FJ, Lubinski A, Kempa M.

Adv Clin Exp Med. 2020 Jan;29(1):123-133. doi: 10.17219/acem/110313.

PMID: 31895976 Free Article

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Select item 30945165

 

  1. Atrial fibrillation ablation in adults with congenital heart disease on uninterrupted oral anticoagulation is safe and efficient.

Kottmaier M, Baur A, Lund S, Bourier F, Reents T, Semmler V, Telishevska M, Berger F, Koch-Büttner K, Lennerz C, Popa M, Kornmayer M, Rousseva E, Brooks S, Brkic A, Grebmer C, Kolb C, Deisenhofer I, Hessling G.

Clin Res Cardiol. 2020 Jan 1. doi: 10.1007/s00392-019-01580-1. [Epub ahead of print]

PMID: 31894385

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Select item 31092183

 

  1. The yield of postmortem genetic testing in sudden death cases with structural findings at autopsy.

Lahrouchi N, Raju H, Lodder EM, Papatheodorou S, Miles C, Ware JS, Papadakis M, Tadros R, Cole D, Skinner JR, Crawford J, Love DR, Pua CJ, Soh BY, Bhalshankar JD, Govind R, Tfelt-Hansen J, Winkel BG, van der Werf C, Wijeyeratne YD, Mellor G, Till J, Cohen M, Tome-Esteban M, Sharma S, Wilde AAM, Cook SA, Sheppard MN, Bezzina CR, Behr ER.

Eur J Hum Genet. 2020 Jan;28(1):17-22. doi: 10.1038/s41431-019-0500-8. Epub 2019 Sep 18.

PMID: 31534214

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Select item 31893560

 

  1. Catheter ablation in children and patients with congenital heart disease: Review of 1021 procedures at a high-volume single center in Japan.

Kato Y, Suzuki T, Yoshida Y, Ozaki N, Kishimoto S, Aoki H, Yoshida S, Watanabe S, Nakamura Y.

Heart Rhythm. 2020 Jan;17(1):49-55. doi: 10.1016/j.hrthm.2019.08.013. Epub 2019 Aug 12.

PMID: 31415819

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Select item 31349063

 

  1. Catheter ablation of supraventricular tachycardia after tricuspid valve surgery in patients with congenital heart disease: A multicenter comparative study.

Moore JP, Gallotti RG, Chiriac A, McLeod CJ, Stephenson EA, Maghrabi K, Fish FA, Kilinc OU, Bradley D, Krause U, Balaji S, Shannon KM.

Heart Rhythm. 2020 Jan;17(1):58-65. doi: 10.1016/j.hrthm.2019.07.020. Epub 2019 Jul 23.

PMID: 31349063

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Select item 31278424

 

  1. Sudden Cardiac Deaths in Adults with Congenital Heart Disease with Structural Abnormalities: A Retrospective Review of Cases in the Cook County Medical Examiner’s Office.

Gitto L, Serinelli S, Arunkumar P, White SM.

J Forensic Sci. 2020 Jan;65(1):117-127. doi: 10.1111/1556-4029.14165. Epub 2019 Aug 12.

PMID: 31404479

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Select item 29614915

 

  1. Placement of Reveal LINQ Device in the Left Anterior Axillary Position.

Anderson H, Dearani J, Qureshi MY, Holst K, O’Leary P, Cannon B, Wackel P.

Pediatr Cardiol. 2020 Jan;41(1):181-185. doi: 10.1007/s00246-019-02242-9. Epub 2019 Nov 19.

PMID: 31745583

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Select item 31729543

 

  1. An International, Multicentered, EvidenceBased Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.

Adler A, Novelli V, Amin AS, Abiusi E, Care M, Nannenberg EA, Feilotter H, Amenta S, Mazza D, Bikker H, Sturm AC, Garcia J, Ackerman MJ, Hershberger RE, Perez MV, Zareba W, Ware JS, Wilde AAM, Gollob MH.

Circulation. 2020 Jan 27. doi: 10.1161/CIRCULATIONAHA.119.043132. [Epub ahead of print] No abstract available.

PMID: 31983240

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Select item 31988139

 

  1. An exploratory assessment of pediatric patient and parent needs after implantable cardioverter defibrillator implant.

Schneider LM, Wong JJ, Trela A, Hanisch D, Shaw RJ, Sears SF, Motonaga KS, Ceresnak SR, Hood KK, Dubin AM.

Pacing Clin Electrophysiol. 2020 Jan 23. doi: 10.1111/pace.13876. [Epub ahead of print]

PMID: 31971265

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Select item 31974717

 

  1. Non-invasive Risk Stratification in Pediatric Ventricular Pre-excitation.

Khaznadar R, Chandler SF, Chaouki AS, Tsao S, Webster G.

Pediatr Cardiol. 2020 Jan 23. doi: 10.1007/s00246-020-02285-3. [Epub ahead of print]

PMID: 31974716

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Select item 31971070

 

  1. Pacing in Patients with Congenital Heart Disease: When Is It Helpful and When Is It Harmful?

Weiland MD, Spector Z, Idriss SF.

Curr Cardiol Rep. 2020 Jan 16;22(1):5. doi: 10.1007/s11886-020-1253-2. Review.

PMID: 31950297

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Select item 31945228

 

  1. Lidocaine versus amiodarone for pediatric in-hospital cardiac arrest: An observational study.

Holmberg MJ, Ross CE, Atkins DL, Valdes SO, Donnino MW, Andersen LW; American Heart Association’s for the AHA’s Get With The Guidelines®-Resuscitation Pediatric Research Task Force.

Resuscitation. 2020 Jan 16. pii: S0300-9572(20)30013-7. doi: 10.1016/j.resuscitation.2019.12.033. [Epub ahead of print]

PMID: 31954741

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  1. A proposed approach to the asymptomatic pediatric patient with Wolff-Parkinson-White pattern.

Chubb H, Ceresnak SR.

HeartRhythm Case Rep. 2020 Jan 15;6(1):2-7. doi: 10.1016/j.hrcr.2019.09.003. eCollection 2020 Jan. No abstract available.

PMID: 31956492 Free PMC Article

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Select item 31980272

 

  1. Prevalence, predictors and complications with defibrillation threshold testing in pediatric patients: Results from the NCDR.

Prutkin JM, Wang Y, Escudero CA, Stephenson EA, Minges KE, Curtis JP, Hsu JC.

Int J Cardiol. 2020 Jan 15. pii: S0167-5273(19)35105-8. doi: 10.1016/j.ijcard.2020.01.027. [Epub ahead of print]

PMID: 31980272

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Select item 31405586

 

  1. P wave dispersion, Tpeak-Tend interval, and Tp-e/QT ratio in children with psoriasis.

Çetin M, Yavuz İH, Gümüştaş M, Yavuz GÖ.

Cardiol Young. 2020 Jan 8:1-5. doi: 10.1017/S1047951119002968. [Epub ahead of print]

PMID: 31910927

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Select item 31910925

 

  1. Effects of maternal sleep position on fetal and maternal heart rate patterns using overnight home fetal ECG recordings.

Lucchini M, Wapner RJ, Chia-Ling NC, Torres C, Yang J, Williams IA, Fifer WP.

Int J Gynaecol Obstet. 2020 Jan 8. doi: 10.1002/ijgo.13096. [Epub ahead of print]

PMID: 31912893

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Select item 31913406

 

  1. Improving long QT syndrome diagnosis by a polynomial-based T-wave morphology characterization.

Hermans BJM, Bennis FC, Vink AS, Koopsen T, Lyon A, Wilde AAM, Nuyens D, Robyns T, Pison L, Postema PG, Delhaas T.

Heart Rhythm. 2020 Jan 7. pii: S1547-5271(20)30001-1. doi: 10.1016/j.hrthm.2019.12.020. [Epub ahead of print]

PMID: 31917370

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Select item 31902322

 

  1. Incidence of supraventricular tachycardia after inhaled short-acting beta agonist treatment in children.

Woodward S, Mundorff M, Weng C, Gamboa DG, Johnson MD.

J Asthma. 2020 Jan 6:1-10. doi: 10.1080/02770903.2019.1709867. [Epub ahead of print]

PMID: 31902263

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Select item 31906753

 

  1. Catheter ablation of supraventricular tachycardia after tricuspid valve surgery in patients with congenital heart disease: A multicenter comparative study.

Moore JP, Gallotti RG, Chiriac A, McLeod CJ, Stephenson EA, Maghrabi K, Fish FA, Kilinc OU, Bradley D, Krause U, Balaji S, Shannon KM.

Heart Rhythm. 2020 Jan;17(1):58-65. doi: 10.1016/j.hrthm.2019.07.020. Epub 2019 Jul 23.

PMID: 31349063

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Select item 31229680

 

  1. Genetic testing and cascade screening in pediatric long QT syndrome and hypertrophic cardiomyopathy.

Knight LM, Miller E, Kovach J, Arscott P, von Alvensleben JC, Bradley D, Valdes SO, Ware SM, Meyers L, Travers CD, Campbell RM, Etheridge SP.

Heart Rhythm. 2020 Jan;17(1):106-112. doi: 10.1016/j.hrthm.2019.06.015. Epub 2019 Jun 20.

PMID: 31229680

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Select item 31169929

 

  1. Myocardial deformation as a predictor of right ventricular pacing-induced cardiomyopathy in the pediatric population.

Dasgupta S, Madani R, Figueroa J, Cox D, Ferguson E, Border W, Sachdeva R, Fischbach P, Whitehill R.

J Cardiovasc Electrophysiol. 2020 Jan;31(1):337-344. doi: 10.1111/jce.14312. Epub 2019 Dec 16.

PMID: 31828872

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Select item 31724792

 

  1. Electrophysiological features and radiofrequency catheter ablation of accessory pathways associated with atrioventricular discordance.

Takeuchi D, Toyohara K, Shoda M, Hagiwara N.

J Cardiovasc Electrophysiol. 2020 Jan;31(1):89-99. doi: 10.1111/jce.14273. Epub 2019 Nov 26.

PMID: 31724792

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Select item 31761510

 

  1. Percutaneous epicardial placement of a prototype miniature pacemaker under direct visualization: An infant porcine chronic survival study.

Kumthekar RN, Opfermann JD, Mass P, Clark BC, Moak JP, Sherwin ED, Whitman T, Marshall M, Berul CI.

Pacing Clin Electrophysiol. 2020 Jan;43(1):93-99. doi: 10.1111/pace.13843. Epub 2019 Dec 11.

PMID: 31721231

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Select item 31701534

 

  1. Catheter ablation of ventricular tachycardia in the pediatric patients: A single-center experience.

Wu J, Chen Y, Ji W, Gu B, Shen J, Fu L, Li F.

Pacing Clin Electrophysiol. 2020 Jan;43(1):37-46. doi: 10.1111/pace.13835. Epub 2019 Dec 2.

PMID: 31701534

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Select item 31897523

 

  1. The Progress and Significance of QRS Duration by Electrocardiography in Hypoplastic Left Heart Syndrome.

Karikari Y, Abdulkarim M, Li Y, Loomba RS, Zimmerman F, Husayni T.

Pediatr Cardiol. 2020 Jan;41(1):141-148. doi: 10.1007/s00246-019-02237-6. Epub 2019 Nov 13.

PMID: 31722042

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Select item 31720782

 

  1. Frequent Ventricular Premature Beats in Children and Adolescents: Natural History and Relationship with Sport Activity in a Long-Term Follow-Up.

Porcedda G, Brambilla A, Favilli S, Spaziani G, Mascia G, Giaccardi M.

Pediatr Cardiol. 2020 Jan;41(1):123-128. doi: 10.1007/s00246-019-02233-w. Epub 2019 Nov 11.

PMID: 31712859

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Select item 31707490

 

  1. Impact of Transcatheter Device Closure of Atrial Septal Defect on Atrial Arrhythmias Propensity in Young Adults.

Ortega MC, Ramos DBB, Novoa JCR, Suarez FJO, Ramírez FD, González MD.

Pediatr Cardiol. 2020 Jan;41(1):54-61. doi: 10.1007/s00246-019-02221-0. Epub 2019 Oct 31.

PMID: 31673734

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Select item 31673733

 

  1. [Structured Reporting in Cross-Sectional Imaging of the Heart: Reporting Templates for CMR Imaging of Cardiomyopathies (Myocarditis, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy and Siderosis)].

Bunck AC, Baeßler B, Ritter C, Kröger JR, Persigehl T, Pinto Santos D, Steinmetz M, Niehaus A, Bamberg F, Beer M, Ley S, Tiemann K, Beerbaum P, Maintz D, Lotz J.

Rofo. 2020 Jan;192(1):e1. doi: 10.1055/a-1034-2379. Epub 2019 Nov 6. German. No abstract available.

PMID: 31694058 Free Article

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  1. Intermuscular S-ICD Implantation in Pediatric Patients.

Ferreiro-Marzal A, Rodríguez-Serrano F, Esteban-Molina M, González-Vargas T, Perin F, Garrido JM.

Thorac Cardiovasc Surg. 2020 Jan;68(1):68-71. doi: 10.1055/s-0039-1697914. Epub 2019 Oct 20.

PMID: 31630382

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Congenital Heart Interventions Featured Articles

Congenital Interventional Cardiology Reviews of January 2020 Manuscripts


 

Routine Surveillance Catheterization is Useful in Guiding Management of Stable Fontan Patients.

Patel ND, Sullivan PM, Sabati A, Hill A, Maedler-Kron C, Zhou S, Shillingford N, Williams R, Takao C, Badran S.

Pediatr Cardiol. 2020 Jan 24. doi: 10.1007/s00246-020-02293-3. [Epub ahead of print]

PMID: 31980851

 

Take Home Points:

 

  • Routine cardiac catheterization is a common part of Fontan surveillance algorithms.
  • Despite appearing to be clinically stable, a large proportion of Fontan patients in this cohort required transcatheter interventions; required initiation of pulmonary vasodilator therapy; and were identified to have hepatic fibrosis.

Commentary from Dr. Konstantin Averin (Edmonton), catheterization section editor of Pediatric Cardiology Journal Watch:  As survival of patients with single ventricle physiology palliated with a Fontan circulation improves it is becoming increasingly recognized that they are prone to developing significant end organ pathology. Various monitoring strategies have been proposed but all usually involve a surveillance catheterization 5-10 years after the Fontan surgery. The value of this assessment has not been fully explored. The authors sought to explore the utility of surveillance cardiac catheterization in stable Fontan patients at a single center.

Sixty-three Fontan patients (mean age 14.6 ± 3.0 and mean time from Fontan surgery 11.3 ± 3.1 years) underwent cardiac catheterization over a 5-year period. The pre-catheterization echocardiograms (within a year) were unremarkable – 80% had normal ventricular function and less than mild AVV insufficiency. Baseline hemodynamics were mostly reassuring with 4 patients having a Fontan pressure > 15 mmHg and 19 having a PVRi > 2.0 iWu. Vasoreactivity testing with iNO was performed in 53 and half had a reduction in the PVRi of at least 20%.

Fifty-seven patients underwent a trans-jugular liver biopsy at the time of procedure with more than half (32/57) demonstrating higher grades of congestive hepatic fibrosis. Forty percent of patients had an intervention at the time of the procedure: pulmonary artery stent (16), existing stent dilation (5), SVC angioplasty (4), Fontan stent (3), and others (7). There were no major complications.

Despite the limitations of this work, the authors demonstrate that routine invasive assessment of Fontan patients can provide valuable information and allow for optimization of the Fontan circulation. Given the high morbidity experienced by this patient population it is important for providers to be pro-active in longitudinal Fontan assessment management as a stable Fontan is not necessarily a good Fontan.

 

CHD Interventions Jan 2020

 

  1. Advances in Pediatric Ductal Intervention: an Open or Shut Case?

Eilers L, Qureshi AM.

Curr Cardiol Rep. 2020 Jan 29;22(3):14. doi: 10.1007/s11886-020-1266-x. Review.

PMID: 31997085

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Select item 32028141

 

  1. Corrigendum to “Deep Tracheal Extubation Using Dexmedetomidine in Children With Congenital Heart Disease Undergoing Cardiac Catheterization: Advantages and Complications”.

[No authors listed]

Semin Cardiothorac Vasc Anesth. 2020 Jan 29:1089253220904808. doi: 10.1177/1089253220904808. [Epub ahead of print] No abstract available.

PMID: 31994447

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Select item 31989135

 

  1. Transcatheter interventions in congenital heart disease: We must have the means to fulfil our ambitions.

Thambo JB.

Arch Cardiovasc Dis. 2020 Jan 23. pii: S1875-2136(20)30005-X. doi: 10.1016/j.acvd.2019.12.001. [Epub ahead of print] No abstract available.

PMID: 31983654

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  1. Increased Cancer Incidence Following up to 15 Years after Cardiac Catheterization in Infants under One Year between 1980 and 1998-A Single Center Observational Study.

Stern H, Seidenbusch M, Hapfelmeier A, Meierhofer C, Naumann S, Schmid I, Spix C, Ewert P.

J Clin Med. 2020 Jan 22;9(2). pii: E315. doi: 10.3390/jcm9020315.

PMID: 31979109 Free Article

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  1. Compression of the left mainstem bronchus by patent ductus arteriosus in neonates under consideration for ductal stenting.

Smith CL, Saul D, Goldfarb SB, Biko DM, O’Byrne ML.

Catheter Cardiovasc Interv. 2020 Jan 20. doi: 10.1002/ccd.28735. [Epub ahead of print]

PMID: 31957932

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  1. Can ductus arteriosus morphology influence technique/outcome of stent treatment?

Roggen M, Cools B, Brown S, Boshoff D, Heying R, Eyskens B, Gewillig M.

Catheter Cardiovasc Interv. 2020 Jan 17. doi: 10.1002/ccd.28725. [Epub ahead of print]

PMID: 31951315

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  1. Recurrent coarctation in Williams syndrome: novel approach of drug-eluting stent implantation.

Tzifa A, Mylonas KS, Halapas A.

Cardiol Young. 2020 Jan 16:1-4. doi: 10.1017/S1047951119003202. [Epub ahead of print]

PMID: 31941559

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  1. ASSURED clinical study: New GORE® CARDIOFORM ASD occluder for transcatheter closure of atrial septal defect.

Sommer RJ, Love BA, Paolillo JA, Gray RG, Goldstein BH, Morgan GJ, Gillespie MJ; ASSURED Investigators.

Catheter Cardiovasc Interv. 2020 Jan 14. doi: 10.1002/ccd.28728. [Epub ahead of print]

PMID: 31943749

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  1. Transcatheter closure of coronary artery fistula: A 21-year experience.

El-Sabawi B, Al-Hijji MA, Eleid MF, Cabalka AK, Ammash NM, Dearani JA, Bjarnason H, Holmes DR, Rihal CS.

Catheter Cardiovasc Interv. 2020 Jan 10. doi: 10.1002/ccd.28721. [Epub ahead of print]

PMID: 31922335

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  1. Predictors of the Need for an Atrial Septal Defect Closure at Very Young Age.

Tanghöj G, Liuba P, Sjöberg G, Naumburg E.

Front Cardiovasc Med. 2020 Jan 10;6:185. doi: 10.3389/fcvm.2019.00185. eCollection 2019.

PMID: 31998753 Free PMC Article

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  1. Impact of Palliation Strategy on Interstage Feeding and Somatic Growth for Infants With Ductal-Dependent Pulmonary Blood Flow: Results from the Congenital Catheterization Research Collaborative.

Nicholson GT, Glatz AC, Qureshi AM, Petit CJ, Meadows JJ, McCracken C, Kelleman M, Bauser-Heaton H, Gartenberg AJ, Ligon RA, Aggarwal V, Kwakye DB, Goldstein BH.

J Am Heart Assoc. 2020 Jan 7;9(1):e013807. doi: 10.1161/JAHA.119.013807. Epub 2019 Dec 19.

PMID: 31852418 Free PMC Article

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Select item 31912176

 

  1. Light anti-thrombotic regimen for prevention of device thrombosis and/or thrombotic complications after interatrial shunts device-based closure.

Rigatelli G, Zuin M, Dell’Avvocata F, Roncon L, Vassilev D, Nghia N.

Eur J Intern Med. 2020 Jan 2. pii: S0953-6205(19)30440-6. doi: 10.1016/j.ejim.2019.12.010. [Epub ahead of print]

PMID: 31902564

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Select item 31926641

 

  1. Pulmonary hypertension after shunt closure in patients with simple congenital heart defects.

Lammers AE, Bauer LJ, Diller GP, Helm PC, Abdul-Khaliq H, Bauer UMM, Baumgartner H; German Competence Network for Congenital Heart Defects Investigators.

Int J Cardiol. 2020 Jan 2. pii: S0167-5273(19)35865-6. doi: 10.1016/j.ijcard.2019.12.070. [Epub ahead of print]

PMID: 31926641

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Select item 31905472

 

  1. Umbilical artery catheter, aortic dissection, carotid cannulation, and pseudoaneurysm in a neonate: A tale of propagating pathology.

Wang J, Semple T, Bautista-Rodriguez C, Hoschtitzky A, Cheshire N, Chan-Dominy A.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):87-90. doi: 10.4103/apc.APC_67_19. Epub 2019 Jul 19.

PMID: 32030043 Free PMC Article

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  1. Balloon pulmonary valvuloplasty in neonates with critical pulmonary stenosis: Jugular or femoral.

Hoetama E, Prakoso R, Roebiono PS, Sakidjan I, Kurniawati Y, Siagian SN, Lelya O, Rahajoe AU, Harimurti GM, Lilyasari O.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):11-15. doi: 10.4103/apc.APC_14_19. Epub 2019 Nov 7.

PMID: 32030030 Free PMC Article

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Select item 31996861

 

  1. Failing mitral homograft in the tricuspid position treated with a percutaneous approach.

Faccini A, Giamberti A, Chessa M.

J Cardiovasc Med (Hagerstown). 2020 Jan;21(1):78-79. doi: 10.2459/JCM.0000000000000875.

PMID: 31592855

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Select item 31746096

 

  1. Influence of Percutaneous Occlusion of Atrial Septal Defect on Left Atrial Function Evaluated Using 2D Speckle Tracking Echocardiography.

Suzuki K, Kato T, Koyama S, Shinohara T, Inukai S, Sato J, Yamamoto H, Omori D, Yoshida S, Takeda S, Nishikawa H, Ohashi N, Sakurai H, Saitoh S.

Int Heart J. 2020 Jan 31;61(1):83-88. doi: 10.1536/ihj.19-173. Epub 2020 Jan 17.

PMID: 31956134 Free Article

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Select item 32014282

 

  1. First in man study of a new semi-open cell design Zephyr cobalt-chromium stent in large vessels and conduits.

Sivakumar K, Anantharaj A, Raghuram P, Krishna Kumar R, Vani P, Neuss M.

Catheter Cardiovasc Interv. 2020 Jan 30. doi: 10.1002/ccd.28737. [Epub ahead of print]

PMID: 31999067

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Select item 32001672

 

  1. Advances in Pediatric Ductal Intervention: an Open or Shut Case?

Eilers L, Qureshi AM.

Curr Cardiol Rep. 2020 Jan 29;22(3):14. doi: 10.1007/s11886-020-1266-x. Review.

PMID: 31997085

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Select item 31995168

 

  1. Routine Surveillance Catheterization is Useful in Guiding Management of Stable Fontan Patients.

Patel ND, Sullivan PM, Sabati A, Hill A, Maedler-Kron C, Zhou S, Shillingford N, Williams R, Takao C, Badran S.

Pediatr Cardiol. 2020 Jan 24. doi: 10.1007/s00246-020-02293-3. [Epub ahead of print]

PMID: 31980851

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Select item 31980646

 

  1. Transcatheter closure of left ventricular pseudoaneurysm after mitral valve replacement.

Arnaz A, Akansel S, Yalcinbas Y, Saygili A, Sarioglu T.

Ann Thorac Surg. 2020 Jan 23. pii: S0003-4975(20)30070-9. doi: 10.1016/j.athoracsur.2019.12.019. [Epub ahead of print]

PMID: 31982444

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  1. Transcatheter closure of a perimembranous ventricular septal defect with Nit-Occlud Lê VSD Coil: A French multicentre study.

Houeijeh A, Godart F, Jalal Z, Ovaert C, Heitz F, Mauran P, Baruteau AE, Guirguis L, Hadeed K, Baudelet JB, Iriart X, Aldebert P, Acar P, Fraisse A, Odemis E, Karsenty C, Thambo JB, Hascoët S.

Arch Cardiovasc Dis. 2020 Jan 22. pii: S1875-2136(20)30015-2. doi: 10.1016/j.acvd.2019.11.004. [Epub ahead of print]

PMID: 31982353

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Select item 31964454

 

  1. In Hospital Complications of Atrial Septal Defect Device Closure at Shahid Gangalal National Heart Centre, Kathmandu, Nepal.

Adhikari CM, Acharya KP, Bogati A, Dhungel S, Shrestha M.

J Nepal Health Res Counc. 2020 Jan 21;17(4):474-478. doi: 10.33314/jnhrc.v17i4.1957.

PMID: 32001851

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Select item 31961960

 

  1. Can ductus arteriosus morphology influence technique/outcome of stent treatment?

Roggen M, Cools B, Brown S, Boshoff D, Heying R, Eyskens B, Gewillig M.

Catheter Cardiovasc Interv. 2020 Jan 17. doi: 10.1002/ccd.28725. [Epub ahead of print]

PMID: 31951315

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Select item 31951249

 

  1. Transcatheter closure of aortopulmonary window with Amplatzer duct occluder II: additional size.

Uçar T, Karagözlü S, Ramoğlu MG, Tutar E.

Cardiol Young. 2020 Jan 13:1-3. doi: 10.1017/S1047951119003342. [Epub ahead of print]

PMID: 31928548

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  1. Right Ventricular Outflow Tract Reintervention in the Transcatheter Era: Outcomes and Cost Analysis.

Crethers D, Kalish J, Shafer B, Mathis L, Polimenakos AC.

Pediatr Cardiol. 2020 Jan 2. doi: 10.1007/s00246-019-02281-2. [Epub ahead of print]

PMID: 31894397

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Select item 31896128

 

  1. [In-utero interventional treatment of two cases with critical aortic stenosis].

Hong NC, Wang L, Wang XP, Zhang CM, Shi XY, Zhang YJ, Lu YN, Wu YR, Chen S, Sun K.

Zhonghua Er Ke Za Zhi. 2020 Jan 2;58(1):51-53. doi: 10.3760/cma.j.issn.0578-1310.2020.01.012. Chinese.

PMID: 31905477

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  1. Comparison of Transcatheter Pulmonic Valve Implantation With Surgical Pulmonic Valve Replacement in Adults (from the National Inpatient Survey Dataset).

Chatterjee A, Bhatia N, Torres MG, Cribbs MG, Mauchley DC, Law MA.

Am J Cardiol. 2020 Jan 1;125(1):135-139. doi: 10.1016/j.amjcard.2019.09.031. Epub 2019 Oct 11.

PMID: 31711632

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Select item 31703806

 

  1. An evolving anesthetic protocol fosters fast tracking in pediatric cardiac surgery: A comparison of two anesthetic techniques.

Sharma VK, Kumar G, Joshi S, Tiwari N, Kumar V, Ramamurthy HR.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):31-37. doi: 10.4103/apc.APC_36_19. Epub 2019 Nov 1.

PMID: 32030033 Free PMC Article

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Select item 32030032

 

  1. Vascular access in pediatric interventions: Science or skill?

Qureshi SA, Kumar RK.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):1-3. doi: 10.4103/apc.APC_213_19. Epub 2020 Jan 9. No abstract available.

PMID: 32030028 Free PMC Article

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Select item 31518582

 

  1. Reversible atrioventricular block after atrial septal defect closure with a Gore Cardioform Septal Occluder.

Figueras-Coll M, Sabaté-Rotés A, Roguera-Sopena M, Betrián-Blasco P.

Arch Cardiol Mex. 2020;90(1):90-92. doi: 10.24875/ACM.M19000214. No abstract available.

PMID: 31996855 Free Article

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Select item 30297440

 

  1. Biventricular Impella use in pediatric patients with severe graft dysfunction from acute rejection after heart transplantation.

Ankola AA, McAllister J, Turner ME, Zuckerman WA, Richmond ME, Addonizio LJ, Lee TM, Law SP.

Artif Organs. 2020 Jan;44(1):100-105. doi: 10.1111/aor.13558. Epub 2019 Oct 7.

PMID: 31429943

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Select item 30908288

 

  1. Transcatheter closure of residual patent ductus arteriosus.

El-Saiedi SA, Elshedoudy SA, El-Sisi AM, Hanna BM, Fattouh AM, Hijazi Z.

Catheter Cardiovasc Interv. 2020 Jan;95(1):78-82. doi: 10.1002/ccd.28338. Epub 2019 May 23.

PMID: 31120630

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Select item 31136304

 

  1. Beyond atrial septal defect closure, it is time to start seriously considering closing ventricular septal defects with devices.

Thompson J.

Curr Opin Cardiol. 2020 Jan;35(1):58-62. doi: 10.1097/HCO.0000000000000695.

PMID: 31652133

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Select item 31644471

 

  1. Current clinical management of dysfunctional bioprosthetic pulmonary valves.

Aggarwal V, Spigel ZA, Hiremath G, Binsalamah Z, Qureshi AM.

Expert Rev Cardiovasc Ther. 2020 Jan;18(1):7-16. doi: 10.1080/14779072.2020.1715796. Epub 2020 Jan 30.

PMID: 31928255

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Select item 31212296

 

  1. Diagnostic Reference Levels, Deterministic and Stochastic Risks in Pediatric Interventional Cardiology Procedures.

Rizk C, Fares G, Vanhavere F, Saliba Z, Farah J.

Health Phys. 2020 Jan;118(1):85-95. doi: 10.1097/HP.0000000000001114.

PMID: 31764423

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Select item 31662332

 

  1. Long-Term Results of Transcatheter Closure of Large Patent Ductus Arteriosus with Severe Pulmonary Arterial Hypertension in Pediatric Patients.

Shah JH, Bhalodiya DK, Rawal AP, Nikam TS.

Int J Appl Basic Med Res. 2020 Jan-Mar;10(1):3-7. doi: 10.4103/ijabmr.IJABMR_192_19. Epub 2020 Jan 3.

PMID: 32002377 Free PMC Article

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Select item 31544560

 

  1. Extracardiac Fontan Fenestration Device Closure with Amplatzer Vascular Plug II and Septal Occluder: Procedure Results and Medium-Term Follow-Up.

Webb MK, Hunter LE, Kremer TR, Huddleston CB, Fiore AC, Danon S.

Pediatr Cardiol. 2020 Jan 1. doi: 10.1007/s00246-019-02283-0. [Epub ahead of print]

PMID: 31894396

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Select item 31894395

 

  1. Indirect Calorimetry Overestimates Oxygen Consumption in Young Children: Caution is Advised Using Direct Fick Method as a Reference Method in Cardiac Output Comparison Studies.

Sigurdsson TS, Lindberg L.

Pediatr Cardiol. 2020 Jan;41(1):149-154. doi: 10.1007/s00246-019-02238-5. Epub 2019 Nov 18.

PMID: 31741015 Free PMC Article

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Select item 31734750

 

  1. Development of a Ductal Aneurysm in a Patient with Williams Syndrome, and Subsequent Interventional Closure.

van den Berg G, Helbing WA, van Beynum I, Krasemann TB.

Pediatr Cardiol. 2020 Jan;41(1):213-214. doi: 10.1007/s00246-019-02211-2. Epub 2019 Sep 18.

PMID: 31535182

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  1. Balloon angioplasty of aortic coarctation in critically ill newborns using axillary artery access.

Meliota G, Lombardi M, Zaza P, Tagliente MR, Vairo U.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):67-71. doi: 10.4103/apc.APC_2_19. Epub 2019 Oct 9.

PMID: 32030037 Free PMC Article

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Select item 32030036

 

  1. Transcatheter closure of atrial septal defect in symptomatic children weighing ≤10 kg: Addressing unanswered issues from a decade of experience.

Sharma B, Pinto R, Dalvi B.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):4-10. doi: 10.4103/apc.APC_66_19. Epub 2019 Dec 4.

PMID: 32030029 Free PMC Article

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Congenital Heart Surgery

Congenital Heart Surgery Reviews of January 2020 Manuscripts


 

Use of a dilatable exGraft™ conduit in single ventricle palliation.

Qadir A, Tannous P, Stephens EH, Kalra A, Forbess JM, Nugent A.

Ann Thorac Surg. 2020 Jan 25. pii: S0003-4975(20)30075-8. doi: 10.1016/j.athoracsur.2019.12.024. [Epub ahead of print]

PMID: 31991132

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Take Home Points: 

  • The major limitation of conduits made with prosthetic material is that they do not dilate much or grow with the patient.
  • The development of a novel, balloon-expandable ePTFE conduit may change the management of patients that require a prosthetic conduit. This is the first published case of this conduit. 

 

Commentary from Dr. Timothy Pirolli (Dallas), section editor of Congenital Heart Surgery Journal Watch:  Surgically-placed conduits and vascular grafts are commonplace in congenital heart surgery. One obvious limitation to placing a prosthetic conduit between a ventricle and great vessel (as opposed to a homograft or autograft) is the lack of growth potential. A prosthetic conduit that could be dilated could revolutionize the field, as it would add the ability to minimize or delay redo surgeries, thus decreasing the associated morbidity and mortality. A start-up company in Pittsburgh (PECA labs) has developed a novel version of the ePTFE graft that has been shown to be dilated up to 200% its original diameter in bench trials.

I chose to highlight this case report because of its novelty. As a disclaimer, I am an unpaid consultant for this company and have had the ability to collaborate with this group of researchers on animal studies, some of which are on-going. Thus, I can attest first-hand that the graft handles well and does indeed dilate without significant recoil months after implantation.  The graft also has the novel advantage of having radiopaque markers on it to allow for safer dilation during catheterization (Figure 1). As mentioned in this case report, the graft is FDA-approved and available for surgical implantation in human beings. This report represents the first published case of implantation and dilation of the novel exGraft™ in a patient undergoing congenital heart surgery.

The case report describes a relatively standard Stage 1 palliation of a baby born with hypoplastic left heart syndrome (MA/AA). The surgeon used of a 6 mm exGraft™ as an RV-PA (Sano) conduit in lieu of the relatively standard ring-enforced PTFE graft that is often used for Sano construction. Aspirin alone was used for shunt thrombosis prophylaxis. The patient underwent a pre-Glenn catheterization at age 5 months. A gradient across the conduit was found to be 60-65 mmHg and the conduit was then dilated to 9 mm by serial dilations (Figure 2).  There was mild residual narrowing at the insertion site into the pulmonary arteries, but otherwise the conduit held its dilated diameter and did not require a stent placement. The patient proceeded to a Glenn at 7 months of age that had an uncomplicated postoperative course. At the time of the explant of the conduit, it had maintained its internal diameter 2 months after dilation (Figure 3).

As stated, this is the first published application of the novel exGraft™ in congenital heart surgery. The safe dilation of the graft to 150% its original diameter in this patient represents a potential milestone for our field. The use of the exGraft™ as a Sano conduit during a stage 1 palliation represents one of many potential uses of this graft. There is a range of sizes that would allow the graft to be used as a modified BT-shunt, interposition graft on large vessels, Fontan conduit and RV-PA conduits on larger children. The ability to implant and later enlarge a prosthetic graft would certainly decrease the morbidity and mortality associated with surgical correction of conduit dysfunction. The company is also working on valved-conduits that are balloon expandable, but those studies are still ongoing. In summary, the exGraft™ from PECA labs has the potential to change the paradigm of the timing and frequency of certain congenital heart surgical procedures.

 

 

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CHD Surgery Jan 2020

 

  1. Surgical repair in a patient with Berry syndrome.

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Select item 31323208

 

  1. Novel Biomarkers Improve Prediction of 365-Day Readmission After Pediatric Congenital Heart Surgery.

Parker DM, Everett AD, Stabler ME, Vricella L, Jacobs ML, Jacobs JP, Parikh CR, Pasquali SK, Brown JR.

Ann Thorac Surg. 2020 Jan;109(1):164-170. doi: 10.1016/j.athoracsur.2019.05.070. Epub 2019 Jul 16.

PMID: 31323208

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Select item 31181204

 

  1. Ross-Konno Operation in an Infant With a Quadricuspid Pulmonary Valve and Anomalous Aortic Origin of the Right Coronary Artery.

Bayle KM, Boston U, Sainathan S, Naik R, Knott-Craig CJ.

Ann Thorac Surg. 2020 Jan;109(1):e41-e43. doi: 10.1016/j.athoracsur.2019.04.061. Epub 2019 Jun 7.

PMID: 31181204

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Select item 31163115

 

  1. Milestone in congenital cardiac surgery: 65 years of the heart-lung machine.

Mazurak M, Kusa J.

Arch Dis Child. 2020 Jan;105(1):92-94. doi: 10.1136/archdischild-2018-315684. Epub 2018 Oct 8. No abstract available.

PMID: 30297440

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Select item 31815306

 

  1. Outcomes of the Fifteenth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion.

Law S, Chai P, Ündar A.

Artif Organs. 2020 Jan;44(1):5-11. doi: 10.1111/aor.13596. No abstract available.

PMID: 31815306

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Select item 31429943

 

  1. Does the pattern of bicuspid aortic valve leaflet fusion determine the success of the Ross procedure?

Ruzmetov M, Fortuna RS, Shah JJ, Welke KF, Plunkett MD.

J Card Surg. 2020 Jan;35(1):28-34. doi: 10.1111/jocs.14294. Epub 2019 Oct 26.

PMID: 31654591

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Select item 31421934

 

  1. First human implantation of a miniaturized axial flow ventricular assist device in a child with end-stage heart failure.

Amodeo A, Filippelli S, Perri G, Iacobelli R, Adorisio R, Iodice F, Rizza A, Massicotte MP, Baldwin JT, Almond CS.

J Heart Lung Transplant. 2020 Jan;39(1):83-87. doi: 10.1016/j.healun.2019.09.003. Epub 2019 Sep 11. No abstract available.

PMID: 31761510

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Select item 30033784

 

  1. Spontaneous “Coronary Bypass” in a Paediatric Transplanted Heart.

Camprubí-Tubella E, Albert-Brotons DC, Betrián-Blasco P.

Pediatr Cardiol. 2020 Jan;41(1):217-219. doi: 10.1007/s00246-019-02278-x. Epub 2020 Jan 2.

PMID: 31897523

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Select item 31894396

 

  1. Outcomes of Supra-annular Mechanical Atrioventricular Valve Replacement with Polytetrafluoroethylene Graft in Infants and Children.

Kwon HW, Kim WH, Lee JR, Kwak JG, Cho S, Bae EJ, Kim GB.

Pediatr Cardiol. 2020 Jan 1. doi: 10.1007/s00246-019-02282-1. [Epub ahead of print]

PMID: 31894395

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Select item 31872283

 

  1. Valve Replacement in Children with Single Ventricle Physiology.

Alshami N, Sarvestani AL, Thomas AS, St Louis J, Kochilas L, Raghuveer G.

Pediatr Cardiol. 2020 Jan;41(1):129-133. doi: 10.1007/s00246-019-02234-9. Epub 2019 Nov 16.

PMID: 31734750

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Select item 31729543

 

  1. Neoaortic Regurgitation in Patients with Transposition Long Term After an Arterial Switch Operation and Its Relation to the Root Diameters and Surgical Technique Used.

Michalak KW, Sobczak-Budlewska K, Moll JJ, Szymczyk K, Moll JA, Łubisz M, Moll M.

Pediatr Cardiol. 2020 Jan;41(1):31-37. doi: 10.1007/s00246-019-02217-w. Epub 2019 Oct 25.

PMID: 31654096

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Select item 31650215

 

  1. Residual Shunts Following Isolated Surgical Ventricular Septal Defect Closure: Risk Factors and Spontaneous Closure.

Deng X, Huang P, Luo J, Chen R, Yang G, Chen W, Liu Q, He C.

Pediatr Cardiol. 2020 Jan;41(1):38-45. doi: 10.1007/s00246-019-02218-9. Epub 2019 Oct 24.

PMID: 31650215

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Select item 31595326

 

 

  1. Diagnosis and Management of Anomalous Left Anterior Descending Coronary Artery from the Pulmonary Artery in an Asymptomatic Infant.

Gupta A, Husain N, Tannous P, Hauck A.

Pediatr Cardiol. 2020 Jan;41(1):209-212. doi: 10.1007/s00246-019-02192-2. Epub 2019 Sep 14.

PMID: 31522266

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Select item 31482238

 

  1. Association of Clinical Rejection Versus Rejection on Protocol Biopsy With Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients.

Asimacopoulos EP, Garbern JC, Gauvreau K, Blume ED, Daly KP, Singh TP.

Transplantation. 2020 Jan;104(1):e31-e37. doi: 10.1097/TP.0000000000002983.

PMID: 31568274

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Select item 31974320

 

  1. [Different surgical approaches to Scimitar syndrome].

Işık O, Akyüz M, Çakmak M, Demircan T, Bakiler AR.

Turk Kardiyol Dern Ars. 2020 Jan;48(1):67-71. doi: 10.5543/tkda.2019.57510. Turkish.

PMID: 31974320 Free Article

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Select item 31162848

 

  1. Rare vascular ring of right aortic arch and aberrant left subclavian artery in association with bilateral ductus arteriosus.

Ma B, Wu L, Zhang W.

Ultrasound Obstet Gynecol. 2020 Jan;55(1):135-137. doi: 10.1002/uog.20365. No abstract available.

PMID: 31162848

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Select item 31835991

 

  1. Surgical Management of Fallot’s Tetralogy With Pulmonary Atresia and Major Aortopulmonary Collateral Arteries: Multistage Versus One-Stage Repair.

Carotti A.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):34-38. doi: 10.1177/2150135119884914.

PMID: 31835990

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Select item 31835989

 

  1. Intraoperative Flow Study Predicted the Postoperative Pulmonary Artery Pressure in the Bidirectional Glenn Operation.

Korun O, Yücel İK, Çiçek M, Altın HF, Yurdakök O, Kılıç Y, Selçuk A, Yurtseven N, Şaşmazel A, Aydemir NA.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):29-33. doi: 10.1177/2150135119884918.

PMID: 31835989

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Select item 31835984

 

  1. Outcomes of Multistage Palliation of Infants With Single Ventricle and Atrioventricular Septal Defect.

Alsoufi B, McCracken C, Kanter K, Shashidharan S, Border W, Kogon B.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):39-48. doi: 10.1177/2150135119885890.

PMID: 31835983

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Select item 31835981

 

  1. Double-Outlet Right Atrium: Review of a Rare Anomaly With an Exemplary Case.

Ambra M, Nuri HA, Giuseppe P, Marasini M, Francesco S.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):79-84. doi: 10.1177/2150135119885895.

PMID: 31835981

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Select item 31835977

 

  1. Utility of Cervical Cannulation During Difficult Resternotomy in Congenital Heart Surgery.

Temur B, Davutoglu A, Dogruoz A, Aydin S, Suzan D, Kırat B, Odemis E, Erek E.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):65-70. doi: 10.1177/2150135119888154.

PMID: 31835977

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Select item 31755355

 

  1. Failure of Cellularization of Ventriculotomy Patch Leading to Right Ventricular Pseudoaneurysm.

Rao S, Stewart RD, Pettersson G, Tan C, Golz S, Komarlu R.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):123-126. doi: 10.1177/2150135119880547. Epub 2019 Nov 22.

PMID: 31755355

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Select item 31658888

 

  1. The Kawashima Operation With Simultaneous Preparation for Transcatheter Fontan-Kreutzer Completion.

Lugones I, Junco N, Biancolini MF, Martínez IA, Damsky Barbosa J.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):105-107. doi: 10.1177/2150135119882327. Epub 2019 Oct 28.

PMID: 31658888

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Fetal Cardiology Featured Articles

Fetal Cardiology Reviews of January 2020 Manuscripts

Isolated ventricular septal defects demonstrated by fetal echocardiography: prenatal course and postnatal outcome.

Raucher Sternfeld A, Sheffy A, Tamir A, Mizrachi Y, Assa S, Shohat M, Berger R, Lev D, Gindes L.

J Matern Fetal Neonatal Med. 2020 Jan 12:1-5. doi: 10.1080/14767058.2020.1712710. [Epub ahead of print]

PMID: 31928261

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Select item 31940858

 

Take Home Points:

 

  • Small muscular VSDs are common in fetal life with almost 50% closing before birth and over 90% closing by 2 years of life
  • Muscular VSDs were not associated with any chromosomal abnormalities or genetic mutations on microarray analysis, but only a small number of patients underwent testing
  • The high incidence and frequency of spontaneous closure along with no genetic abnormality may suggest that the presence of small muscular VSDs may be a delayed physiological process as opposed to something pathologic, but this premise should be studied further
  • Perimembranous VSDs are less likely to close and more likely to be associated with a genetic abnormality

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch:  VSDs are the most common congenital cardiac malformation and often diagnosed prenatally. Most VSDs will have little hemodynamic effect prenatally due to equal pressure in both ventricles and limited shunting and many close during fetal life or within a few years after birth. This was a retrospective study looking at prenatal course and postnatal outcomes in fetuses diagnosed with VSDs over a 4 year study period of 7466 fetal echocardiograms. 59 cases of complicated CHD was seen (0.79%). 86 isolated VSDs were diagnosed (1.17%) with 11 cases excluded due to loss of follow up. 64/75 patients had muscular VSDs with a mean size of 1.1 mm and median maximal size of 1 mm. In comparison, perimembranous VSDs had a mean size of 2.5 mm and a median size of 3.5 mm.

The authors note that all fetuses with a VSD are referred for genetic consultation at this study center and each family can decide on testing. 19 fetuses subsequently had a karyotype and 4 fetuses had a complete microarray. All fetuses had normal testing except for 1 with Down Syndrome who had a perimembranous VSD. Spontaneous closure occurred in 92% of the muscular VSDs during the study period (up to 2 years) and 48.4% closed before birth. This contrasted with perimembranous VSDs, with 45.5% closing over 2 years and 27% before birth (see Table 1). Amongst all VSDs, those that closed spontaneously were significantly smaller than those that remained open (1.48 +/- 0.68 mm vs. 2.6 +/- 1.25 mm).

The authors conclude that muscular VSDs are common, are not associated with chromosomal aberrations, and often close spontaneously. They suggest that the presence of these VSDs may actually represent a delayed physiologic process rather than something pathologic. A significant caveat to this would be that very few patients in their study actually underwent genetic testing (specifically microarray) and it is possible that there may be some genetic mutations that would be associated with VSDs. However, invasive genetic testing such as amniocentesis should likely not be recommended for this patient population.

Additionally, the overall number of patients was small and while they mention size as a significant factor for spontaneous closure, nearly all of those patients had muscular VSDs anyway. I do think that this study adds to the objective ability of fetal cardiologists to reassure patients when small muscular VSDs are seen even though most of us have recognized this by experience.

 

Umbilical Cord Blood Gas in Newborns with Prenatal Diagnosis of Congenital Heart Disease: Insight into In-Utero and Delivery Hemodynamics.

Adams AD, Aggarwal N, Iqbal SN, Tague L, Skurow-Todd K, McCarter R, Donofrio MT.

Pediatr Cardiol. 2019 Dec;40(8):1575-1583. doi: 10.1007/s00246-019-02189-x. Epub 2019 Aug 30.

PMID:  31471626

Similar articles

 

 

Take Home Points:

  • Newborns with a prenatal diagnosis of congenital heart disease are not at increased risk of acidosis at the time of delivery when compared to gestational age-matched controls.
  • No difference was noticed in the umbilical arterial (UA) pH between those with single ventricle vs two-ventricle disease and those with and without aortic arch obstruction.
  • In pregnancies complicated by congenital heart disease, spontaneous vaginal delivery with prolonged labor seems to impact the fetal outcome as noted by the significant decline in UA pH with increasing duration of labor in this group when compared to other modes such as induced vaginal delivery and C-Section post-labor.

 

Commentary from Dr. Venu Amula  (Salt Lake City), section editor of Fetal Cardiology Journal Watch:  The American College of Obstetricians and Gynecologists and the American Academy of Pediatrics recommend performing umbilical artery blood acid-base analysis after certain high-risk deliveries in which a fetal metabolic abnormality is suspected to assess fetal well-being. Adams et al conducted this single-center, retrospective observational study to determine if newborns with congenital heart disease are at a higher risk for acidosis at delivery as determined by the umbilical cord blood analysis. The control group included singleton deliveries without CHD matched by date of birth and gestational age. The authors also sought to determine if specific fetal cardiac diagnosis, type, and duration of labor are associated with acidosis. The cases included all forms of complex congenital heart disease. Given the unique physiological challenges faced by single ventricle heart lesions and those with systemic outflow obstruction – the lesions were divided into 4 categories – Single Ventricle lesions with and without aortic arch obstruction, and Biventricular lesions with and without aortic arch obstruction. Class, I was defined as patients with two ventricles without aortic arch obstruction Class II as patients with two ventricles with arch obstruction, Class III as patients with a single ventricle without arch obstruction and Class IV as patients with a single ventricle with arch obstruction.

The study cohort consisted of 134 cases with an equal number of gestational and calendar year matched healthy newborns. Overall there was no difference in the median UA pH in the cases with congenital heart disease versus the control group. There was also no difference by physiological class nor by single ventricle vs two ventricle type nor by the presence or absence of aortic arch obstruction. The authors conclude that fetuses with congenital heart disease have well-compensated hemodynamics and inutero oxygen delivery owing to fetoplacental circulation regardless of the subtype of congenital heart disease.

They also evaluated the effect of mode of delivery on UA pH and found that in the congenital heart disease group there was a significant decline in the median UA pH with increasing duration of labor in those with spontaneous vaginal delivery when compared to those with induced vaginal and C-Section Post-Labor. However, it is to be noted that even in this group pathological fetal acidemia, a practical pH threshold where neonatal morbidity increases i.e. umbilical artery pH <7, was rare.

The study is limited by a sampling bias given no umbilical arterial blood analysis data was present for those with hemodynamically unstable neonates with congenital heart lesions. Maternal characteristics were also not completely matched given the placental health may impact umbilical cord gas analysis even though venous sampling would be more reflective of that.

Duration of labor in fetuses with the diagnosis of congenital heart disease planned for spontaneous vaginal delivery may impact the outcome as evidenced by declining UA pH and needs planned perinatal management.

 

Fetal Cardiology Jan 2020

 

  1. Identification of FOXH1 mutations in patients with sporadic conotruncal heart defect.

Wei W, Li B, Li F, Sun K, Jiang X, Xu R.

Clin Genet. 2020 Jan 31. doi: 10.1111/cge.13710. [Epub ahead of print]

PMID: 32003456

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Select item 32014568

 

  1. Autopsy and postnatal follow-up of prenatally diagnosed ventricular outpouchings.

Zheng M, Sun L, Liu X, Wang X, He Y.

Prenat Diagn. 2020 Jan 28. doi: 10.1002/pd.5646. [Epub ahead of print]

PMID: 31990991

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Select item 31989331

 

  1. MicroRNA-144 Regulates Cardiomyocyte Proliferation and Apoptosis by Targeting TBX1 through the JAK2/STAT1 Pathway.

Cao ML, Zhu BL, Sun YY, Qiu GR, Fu WN, Jiang HK.

Cytogenet Genome Res. 2020 Jan 24. doi: 10.1159/000505143. [Epub ahead of print]

PMID: 31982878

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Select item 31980926

 

  1. A single nucleotide deletion resulting in a frameshift in exon 4 of TAB2 is associated with a polyvalular syndrome.

Permanyer E, Laurie S, Blasco-Lucas A, Maldonado G, Amador-Catalan A, Ferrer-Curriu G, Fuste B, Perez ML, Gonzalez-Alujas T, Beltran S, Comas-Riu J, Bardají A, Evangelista A, Galiñanes M.

Eur J Med Genet. 2020 Jan 23:103854. doi: 10.1016/j.ejmg.2020.103854. [Epub ahead of print]

PMID: 31981616

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Select item 31976751

 

  1. An analysis of 109 fetuses with prenatal diagnosis of complete agenesis of corpus callosum.

Bayram AK, Kütük MS, Doganay S, Özgün MT, Gümüş H, Başbuğ M, Kumandaş S, Canpolat M, Per H.

Neurol Sci. 2020 Jan 22. doi: 10.1007/s10072-019-04224-4. [Epub ahead of print]

PMID: 31970575

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Select item 31969166

 

  1. Correction: MIB1 mutations reduce notch signaling activation and contribute to congenital heart disease.

[No authors listed]

Clin Sci (Lond). 2020 Jan 17;134(1):1. doi: 10.1042/CS-20180732_COR. No abstract available.

PMID: 31894840

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Select item 31848133

 

  1. Detection of fetal cardiac anomalies: is increasing the number of cardiac views cost-effective?

Bak GS, Shaffer BL, Madriago E, Allen A, Kelly B, Caughey AB, Pereira L.

Ultrasound Obstet Gynecol. 2020 Jan 16. doi: 10.1002/uog.21977. [Epub ahead of print]

PMID: 31945242

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Select item 31941532

 

  1. De novo variants in exomes of congenital heart disease patients identify risk genes and pathways.

Sevim Bayrak C, Zhang P, Tristani-Firouzi M, Gelb BD, Itan Y.

Genome Med. 2020 Jan 15;12(1):9. doi: 10.1186/s13073-019-0709-8.

PMID: 31941532 Free PMC Article

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Select item 31371115

 

  1. Association of Maternal Psychological Distress With In Utero Brain Development in Fetuses With Congenital Heart Disease.

Wu Y, Kapse K, Jacobs M, Niforatos-Andescavage N, Donofrio MT, Krishnan A, Vezina G, Wessel D, du Plessis A, Limperopoulos C.

JAMA Pediatr. 2020 Jan 13:e195316. doi: 10.1001/jamapediatrics.2019.5316. [Epub ahead of print]

PMID: 31930365

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Select item 31993452

 

  1. Comprehensive Functional Echocardiographic Assessment of Transposition of the Great Arteries: From Fetus to Newborn.

Walter C, Soveral I, Bartrons J, Escobar MC, Carretero JM, Quirado L, Gómez O, Sánchez-de-Toledo J.

Pediatr Cardiol. 2020 Jan 10. doi: 10.1007/s00246-019-02279-w. [Epub ahead of print]

PMID: 31919591

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Select item 31931249

 

  1. Bi-allelic Mutations in NADSYN1 Cause Multiple Organ Defects and Expand the Genotypic Spectrum of Congenital NAD Deficiency Disorders.

Szot JO, Campagnolo C, Cao Y, Iyer KR, Cuny H, Drysdale T, Flores-Daboub JA, Bi W, Westerfield L, Liu P, Leung TN, Choy KW, Chapman G, Xiao R, Siu VM, Dunwoodie SL.

Am J Hum Genet. 2020 Jan 2;106(1):129-136. doi: 10.1016/j.ajhg.2019.12.006. Epub 2019 Dec 26.

PMID: 31883644

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Select item 31870554

 

  1. Complete Sequence of the 22q11.2 Allele in 1,053 Subjects with 22q11.2 Deletion Syndrome Reveals Modifiers of Conotruncal Heart Defects.

Zhao Y, Diacou A, Johnston HR, Musfee FI, McDonald-McGinn DM, McGinn D, Crowley TB, Repetto GM, Swillen A, Breckpot J, Vermeesch JR, Kates WR, Digilio MC, Unolt M, Marino B, Pontillo M, Armando M, Di Fabio F, Vicari S, van den Bree M, Moss H, Owen MJ, Murphy KC, Murphy CM, Murphy D, Schoch K, Shashi V, Tassone F, Simon TJ, Shprintzen RJ, Campbell L, Philip N, Heine-Suñer D, García-Miñaúr S, Fernández L; International 22q11.2 Brain and Behavior Consortium, Bearden CE, Vingerhoets C, van Amelsvoort T, Eliez S, Schneider M, Vorstman JAS, Gothelf D, Zackai E, Agopian AJ, Gur RE, Bassett AS, Emanuel BS, Goldmuntz E, Mitchell LE, Wang T, Morrow BE.

Am J Hum Genet. 2020 Jan 2;106(1):26-40. doi: 10.1016/j.ajhg.2019.11.010. Epub 2019 Dec 20.

PMID: 31870554

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Select item 31897601

 

  1. Homeobox Genes and Homeodomain Proteins: New Insights into Cardiac Development, Degeneration and Regeneration.

Miksiunas R, Mobasheri A, Bironaite D.

Adv Exp Med Biol. 2020;1212:155-178. doi: 10.1007/5584_2019_349. Review.

PMID: 30945165

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Select item 31711632

 

  1. From embryogenesis to adulthood: Critical role for GATA factors in heart development and function.

Whitcomb J, Gharibeh L, Nemer M.

IUBMB Life. 2020 Jan;72(1):53-67. doi: 10.1002/iub.2163. Epub 2019 Sep 13. Review.

PMID: 31520462

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Select item 31668503

 

  1. Chromosomal microarray analysis for the detection of chromosome abnormalities in fetuses with echogenic intracardiac focus in women without high-risk factors.

He M, Zhang Z, Hu T, Liu S.

Medicine (Baltimore). 2020 Jan;99(5):e19014. doi: 10.1097/MD.0000000000019014.

PMID: 32000445 Free Article

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Select item 31914083

 

  1. Correlations between ISL1 rs1017 polymorphism and congenital heart disease risk: A PRISMA-compliant meta-analysis.

Ding Z, Yang W, Yi K, Ding Y, Zhou D, Xie X, You T.

Medicine (Baltimore). 2020 Jan;99(2):e18715. doi: 10.1097/MD.0000000000018715.

PMID: 31914083 Free PMC Article

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Select item 31914027

 

  1. New Insights into the Impact of Genome-Wide Copy Number Variations on Complex Congenital Heart Disease in Saudi Arabia.

Dasouki MJ, Wakil SM, Al-Harazi O, Alkorashy M, Muiya NP, Andres E, Hagos S, Aldusery H, Dzimiri N, Colak D.

OMICS. 2020 Jan;24(1):16-28. doi: 10.1089/omi.2019.0165. Epub 2019 Dec 19.

PMID: 31855513

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Select item 31872283

 

  1. Genetic Contribution to Congenital Heart Disease (CHD).

Shabana NA, Shahid SU, Irfan U.

Pediatr Cardiol. 2020 Jan;41(1):12-23. doi: 10.1007/s00246-019-02271-4. Epub 2019 Dec 23. Review.

PMID: 31872283

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Select item 31811329

 

 

  1. In fetuses with congenital lung masses, decreased ventricular and atrioventricular valve dimensions are associated with lesion size and clinical outcome.

Mardy C, Blumenfeld YJ, Arunamata AA, Girsen AI, Sylvester KG, Halabi S, Rubesova E, Hintz SR, Tacy TA, Maskatia SA.

Prenat Diagn. 2020 Jan;40(2):206-215. doi: 10.1002/pd.5612. Epub 2019 Dec 1.

PMID: 31742724

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Select item 31652332

 

  1. Improving fetal congenital heart disease screening using a checklist-based approach.

Janicki MB, Fernandez CG, Wakefield D, Shepherd JP, Figueroa R.

Prenat Diagn. 2020 Jan;40(2):223-231. doi: 10.1002/pd.5581. Epub 2019 Dec 9.

PMID: 31652332

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Select item 31687920

 

  1. Hemodynamic Responses of the Placenta and Brain to Maternal Hyperoxia in Fetuses with Congenital Heart Disease by Using Blood Oxygen-Level Dependent MRI.

You W, Andescavage NN, Kapse K, Donofrio MT, Jacobs M, Limperopoulos C.

Radiology. 2020 Jan;294(1):141-148. doi: 10.1148/radiol.2019190751. Epub 2019 Nov 5.

PMID: 31687920

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Select item 31920043

 

  1. [Ebstein’s anomaly : from fetal diagnosis to surgical treatment].

Madani S, Van Linthout C, Rondia G, Seghaye MC.

Rev Med Liege. 2020 Jan;75(1):43-48. French.

PMID: 31920043

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Select item 31794068

 

  1. Generation of a gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G > A alteration in DAND5.

Inácio JM, Almeida M, Cristo F, Belo JA.

Stem Cell Res. 2020 Jan;42:101677. doi: 10.1016/j.scr.2019.101677. Epub 2019 Dec 20.

PMID: 31869685 Free Article

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Select item 30609447

 

  1. Identification of FOXH1 mutations in patients with sporadic conotruncal heart defect.

Wei W, Li B, Li F, Sun K, Jiang X, Xu R.

Clin Genet. 2020 Jan 31. doi: 10.1111/cge.13710. [Epub ahead of print]

PMID: 32003456

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Select item 32004080

 

  1. Essential role of the ELABELA-APJ signaling pathway in cardiovascular system development and diseases.

Zhou S, Wang J, Wang Q, Meng Z, Peng J, Song W, Zhou Y.

J Cardiovasc Pharmacol. 2020 Jan 29. doi: 10.1097/FJC.0000000000000803. [Epub ahead of print]

PMID: 32000202

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Select item 31995438

 

  1. Abstracts From 10th Annual Phoenix Fetal Cardiology Symposium November 7-11, 2019 Phoenix, Arizona.

[No authors listed]

Pediatr Cardiol. 2020 Jan 17. doi: 10.1007/s00246-019-02261-6. [Epub ahead of print] No abstract available.

PMID: 31953570

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Select item 31951681

 

  1. Detection of fetal cardiac anomalies: is increasing the number of cardiac views cost-effective?

Bak GS, Shaffer BL, Madriago E, Allen A, Kelly B, Caughey AB, Pereira L.

Ultrasound Obstet Gynecol. 2020 Jan 16. doi: 10.1002/uog.21977. [Epub ahead of print]

PMID: 31945242

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Select item 31734412

 

  1. Automatic detection of complete and measurable cardiac cycles in antenatal pulsed-wave Doppler signals.

Sulas E, Urru M, Tumbarello R, Raffo L, Pani D.

Comput Methods Programs Biomed. 2020 Jan 15;190:105336. doi: 10.1016/j.cmpb.2020.105336. [Epub ahead of print]

PMID: 32007836 Free Article

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Select item 31956492

 

  1. Isolated ventricular septal defects demonstrated by fetal echocardiography: prenatal course and postnatal outcome.

Raucher Sternfeld A, Sheffy A, Tamir A, Mizrachi Y, Assa S, Shohat M, Berger R, Lev D, Gindes L.

J Matern Fetal Neonatal Med. 2020 Jan 12:1-5. doi: 10.1080/14767058.2020.1712710. [Epub ahead of print]

PMID: 31928261

Similar articles

Select item 31940858

 

  1. Comprehensive Functional Echocardiographic Assessment of Transposition of the Great Arteries: From Fetus to Newborn.

Walter C, Soveral I, Bartrons J, Escobar MC, Carretero JM, Quirado L, Gómez O, Sánchez-de-Toledo J.

Pediatr Cardiol. 2020 Jan 10. doi: 10.1007/s00246-019-02279-w. [Epub ahead of print]

PMID: 31919591

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Select item 31925535

 

  1. Early cardiac remodeling in aortic coarctation: insights from fetal and neonatal functional and structural assessment.

Soveral I, Crispi F, Walter C, Guirado L, García-Cañadilla P, Cook A, Bonnin A, Dejea H, Rovira-Zurriaga C, Sánchez de Toledo J, Gratacós E, Martínez JM, Bijnens B, Gómez O.

Ultrasound Obstet Gynecol. 2020 Jan 7. doi: 10.1002/uog.21970. [Epub ahead of print]

PMID: 31909552

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Select item 31907356

 

  1. Complete Fetal Atrioventricular Block Associated with Maternal Autoinflammatory Diseases: Case Report and Literature Review.

Tugcu AU, Ince DA, Esin S, Turan O, Erdogan I, Ecevit A.

Acta Cardiol Sin. 2020 Jan;36(1):72-75. doi: 10.6515/ACS.202001_36(1).20190711A. No abstract available.

PMID: 31903011 Free PMC Article

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Select item 31432551

 

  1. X-chromosome association studies of congenital heart defects.

Agopian AJ, Hoang TT, Goldmuntz E, Hakonarson H, Musfee FI, Mitchell LE; Pediatric Cardiac Genomics Consortium.

Am J Med Genet A. 2020 Jan;182(1):250-254. doi: 10.1002/ajmg.a.61411. Epub 2019 Nov 15. No abstract available.

PMID: 31729158

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Select item 31898418

 

 

  1. Coronary Intimal Thickening Begins in Fetuses and Progresses in Pediatric Population and Adolescents to Atherosclerosis.

Guerri-Guttenberg R, Castilla R, Cao G, Azzato F, Ambrosio G, Milei J.

Angiology. 2020 Jan;71(1):62-69. doi: 10.1177/0003319719849784. Epub 2019 May 14.

PMID: 31088126

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Select item 31475425

 

  1. Genetic abnormalities/syndromes significantly impact perioperative outcomes of conotruncal heart defects.

Lahiri S, Gil W, Daria S, Joshua G, Parul J, Redmond B, Elizabeth W.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):38-45. doi: 10.4103/apc.APC_51_19. Epub 2019 Oct 9.

PMID: 32030034 Free PMC Article

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Select item 32030033

 

  1. Evolution of strain and strain rate values throughout gestation in healthy fetuses.

Clavero Adell M, Ayerza Casas A, Jiménez Montañés L, Palanca Arias D, López Ramón M, Alcalá Nalvaiz JT, Samper Villagrasa P.

Int J Cardiovasc Imaging. 2020 Jan;36(1):59-66. doi: 10.1007/s10554-019-01695-6. Epub 2019 Oct 29.

PMID: 31664680

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Select item 31502067

 

  1. Modified myocardial performance index and its prognostic significance for adverse perinatal outcome in early and late onset fetal growth restriction.

Alici Davutoglu E, Ozel A, Oztunc F, Madazli R.

J Matern Fetal Neonatal Med. 2020 Jan;33(2):277-282. doi: 10.1080/14767058.2018.1489534. Epub 2018 Jul 22.

PMID: 30033784

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Select item 31215308

 

  1. Current and future role of fetal cardiovascular MRI in the setting of fetal cardiac interventions.

Marini D, Xu J, Sun L, Jaeggi E, Seed M.

Prenat Diagn. 2020 Jan;40(1):71-83. doi: 10.1002/pd.5626. Epub 2019 Dec 19.

PMID: 31834624

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Select item 31956525

 

Congenital Heart Anesthesia and Intensive Care

Anesthesia Critical Care Jan 2020

 

  1. Heart rate changes following the administration of sugammadex in children: a prospective, observational study.

Alsuhebani M, Sims T, Hansen JK, Hakim M, Walia H, Miller R, Tumin D, Tobias JD.

J Anesth. 2020 Jan 24. doi: 10.1007/s00540-019-02729-y. [Epub ahead of print]

PMID: 31980926

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Select item 31987651

 

  1. Three-year experience with immediate extubation in pediatric patients after congenital cardiac surgery.

Tirotta CF, Alcos S, Lagueruela RG, Salyakina D, Wang W, Hughes J, Irizarry M, Burke RP.

J Cardiothorac Surg. 2020 Jan 6;15(1):1. doi: 10.1186/s13019-020-1051-3.

PMID: 31906990 Free PMC Article

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Select item 31899550

 

  1. Evaluation of an updated sedation protocol to reduce benzodiazepines in a pediatric intensive care unit.

Michel J, Hofbeck M, Peper AK, Kumpf M, Neunhoeffer F.

Curr Med Res Opin. 2020 Jan;36(1):1-6. doi: 10.1080/03007995.2019.1663689. Epub 2019 Sep 17.

PMID: 31526142

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Select item 31644471

 

  1. Preliminary experience of tigecycline treatment in critically ill children with ventilator-associated pneumonia.

Lin S, Liang L, Zhang C, Ye S.

J Int Med Res. 2020 Jan;48(1):300060518760435. doi: 10.1177/0300060518760435. Epub 2018 Apr 3. No abstract available.

PMID: 29614915

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Select item 31289972

 

  1. Dexmedetomidine improves neurodevelopment and cognitive impairment in infants with congenital heart disease.

Huang J, Gou B, Rong F, Wang W.

Per Med. 2020 Jan;17(1):33-41. doi: 10.2217/pme-2019-0003. Epub 2019 Dec 16.

PMID: 31841075

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Select item 31742724

 

  1. The Congenital Cardiac Anesthesia Society-Society of Thoracic Surgeons Cardiac Anesthesia Database Collaboration.

Vener DF, Abbasi RK, Brown M, Greene N, Guzzetta NA, Jacobs JP, Latham G, Mossad E, Nicolson SC, Twite M, Zhang S, Wise-Faberowski L.

World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):14-21. doi: 10.1177/2150135119884911.

PMID: 31835986

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Select item 31835985

 

  1. Depth of anesthesia by Narcotrend®and postoperative characteristics in children undergoing cardiac surgery under extracorporeal circulation: a retrospective comparison of two anesthetic regimens.

Plaschke K, Weiskircher A, Benner L, Klein B, Loukanov T, Gorenflo M, Weigand MA, Rauch H.

Perfusion. 2020 Jan 11:267659119895447. doi: 10.1177/0267659119895447. [Epub ahead of print]

PMID: 31928325

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Select item 31924159

 

  1. Nonopioid analgesics for perioperative and cardiac surgery pain in children: Current evidence and knowledge gaps.

Saini A, Maher KO, Deshpande SR.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):46-55. doi: 10.4103/apc.APC_190_18. Epub 2019 Dec 4. Review.

PMID: 32030035 Free PMC Article

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Select item 32030034

 

  1. An evolving anesthetic protocol fosters fast tracking in pediatric cardiac surgery: A comparison of two anesthetic techniques.

Sharma VK, Kumar G, Joshi S, Tiwari N, Kumar V, Ramamurthy HR.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):31-37. doi: 10.4103/apc.APC_36_19. Epub 2019 Nov 1.

PMID: 32030033 Free PMC Article

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Select item 32030032

 

  1. Evaluation of an updated sedation protocol to reduce benzodiazepines in a pediatric intensive care unit.

Michel J, Hofbeck M, Peper AK, Kumpf M, Neunhoeffer F.

Curr Med Res Opin. 2020 Jan;36(1):1-6. doi: 10.1080/03007995.2019.1663689. Epub 2019 Sep 17.

PMID: 31526142

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Select item 31652133

 

  1. Nonopioid analgesics for perioperative and cardiac surgery pain in children: Current evidence and knowledge gaps.

Saini A, Maher KO, Deshpande SR.

Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):46-55. doi: 10.4103/apc.APC_190_18. Epub 2019 Dec 4. Review.

PMID: 32030035 Free PMC Article

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The CHIP Network Journal Watch Team

Konstantin Averin, MD, MS is an Associate Professor of Pediatrics at the University of Alberta and an Interventional Pediatric Cardiologist at the Stollery Children’s Hospital in Edmonton, Alberta. He received his medical degree from the Feinberg School of Medicine at Northwestern University in Chicago, IL. After medical school, he completed pediatrics residency, pediatric cardiology fellowship and sub-specialty training in pediatric and adult interventional cardiology at the Cincinnati Children’s Hospital in Cincinnati, OH. His clinical and research interests are focused on the percutaneous treatment of pediatric patients with congenital and acquired heart disease with a focus on patients with single ventricle physiology, transcatheter pulmonary valves, and pulmonary hypertension.

Dr. Leong Ming Chern “MC” is an adult congenital heart disease specialist at the National Heart Institute, Kuala Lumpur, Malaysia. He received his medical training at the University of Malaya and pediatric cardiology training at the National Heart Institute. His area of interest includes treatment of adult patients with congenital heart disease and pulmonary hypertension in congenital heart disease.

Dr. Damien Cullington, MBChB MRCP MD FESC is a consultant adult congenital cardiologist who works at Leeds General Infirmary, UK. In summer 2019, he will move over to the newly commissioned North West ACHD Service based in Liverpool, UK. Damien qualified in 2002 from the University of Liverpool and became a substantive consultant in 2016. Prior to this, he worked throughout the North of England and Yorkshire as a cardiology trainee. Damien was awarded a doctorate in medicine (MD) from the University of Hull in 2013 for his work in heart rate in patients with heart failure. He is a member of the Royal College of Physicians (London), Fellow of the European Society of Cardiology and honorary senior lecturer for the University of Leeds. His ACHD subspecialty clinical interests are heart failure, imaging and palliative care. He is regional organiser for ACHD training at Leeds and clinical governance lead for the Leeds congenital cardiac unit. His research interests and wide and far but particularly epidemiology, chronic heart failure in ACHD patients in all its guises, the systemic RV and the univentricle

Dr. Blanche Cupido is a consultant adult cardiologist working at Groote Schuur Hospital, UCT Private Academic Hospital and the University of Cape Town(UCT), South Africa. She completed her physician training in 2009 and her cardiology subspecialist training in 2013. She recently returned to SA after doing a Fellowship in Adult Congenital Heart Disease in Leeds, United Kingdom under the guidance of Dr Kate English. She has established a dedicated unit for Grown Up Congenital Heart Disease in Cape Town, South Africa. Her aim is to grow ACHD services in Sub-Saharan Africa and embark on GUCH research on the African continent.

Dr. Jeremy L. Herrmann is an Assistant Professor of Surgery in the Division of Thoracic and Cardiovascular Surgery at Indiana University. He specializes in pediatric and adult congenital cardiac surgery, and his clinical interests also include heart transplantation and mechanical circulatory support. His hospital affiliations include Indiana University Health Riley Hospital for Children and Methodist Hospital as well as Peyton Manning Children’s Hospital at St. Vincent Hospital in Indianapolis

Maan Jokhadar is a cardiologist and associate professor of medicine at Emory University in Atlanta, Georgia. He is board certified in internal medicine, cardiovascular disease, advanced heart failure/transplantation, adult congenital heart disease, and echocardiography. He is fellowship director for the Emory Adult Congenital Heart Disease training program and Core Curriculum Director for the Emory general cardiology fellowship program. Dr Jokhadar graduated from the University Damascus School of Medicine in Syria and then went to Mayo Clinic in Rochester, Minnesota for internal medicine residency. He then completed cardiology and subspecialty training at Emory University, where he currently on faculty. Dr. Jokhadar has been the recipient of numerous teaching awards. He is married with 3 children.

Michael Ma, MD is an Assistant Professor in Cardiothoracic Surgery in the Division of Pediatric Cardiac Surgery at Stanford University. He specializes in pediatric and adult congenital cardiac surgery, with an emphasis on neonates, complex biventricular repair, and pulmonary artery reconstruction. His research lab investigates ex and in vivo translational models for complex congenital heart disease, to optimize future surgical and endovascular repair strategies.

Jeremy P. Moore MD MS FHRS is the Director of Clinical Research and faculty in Pediatric Cardiology and Adult Congenital Heart Disease at the University of California, Los Angeles. Dr. Moore received his medical degree from the Medical College of Virginia in 2003. He completed residency and fellowship at UCLA before pursuing his subspecialty training in Pediatric Electrophysiology at Vanderbilt University in 2009. Dr. Moore has been faculty at UCLA since 2010 and has since published numerous research manuscripts dealing with electrophysiologic aspects pertinent to congenital heart disease. Dr. Moore’s primary interest is the study of mechanisms of arrhythmia, and the development of novel electrophysiologic techniques for management of the adult patient with congenital heart disease

Dr. Mehul Patel MD, is a structural and adult congenital heart disease specialist and an interventional cardiologist. Dr. Patel earned his undergraduate and medical education from the Mumbai University, India. After completing his post-graduate training in Internal Medicine and Cardiology, he further trained in interventional cardiology at the Mount Sinai Medical Center, NYC, NY and Adult Congenital Heart Disease at the Texas Children’s Hospital, Texas Heart Institute, Baylor College of Medicine, Houston, TX. Dr. Patel worked as Chief of adult congenital heart disease, Assistant Professor at the Michigan State University, Grand Rapids, MI where he not only expanded the program, performing complex interventions and device implantations but also established the percutaneous pulmonary valve implantation (Melody Valve) Program. Due to his passion for treating structurally abnormal hearts, he did a dedicated year of Structural Heart Disease fellowship at Henry Ford Hospital, Detroit, MI where he worked with pioneers in this field before moving to North Carolina. He is proficient in performing transcatheter aortic valve replacement (TAVR), MitraClip, Watchman device implantation, percutaneous Mitral, Tricuspid and Pulmonary valve replacements along with a variety of interventions on congenital heart disease and pulmonary hypertension. Dr. Patel is ABIM board certified in Internal Medicine, Cardiology, Interventional cardiology and Adult Congenital Heart Disease. Dr. Patel has more than 50 peer reviewed publications and numerous abstracts to his credit. He serves as a Co-Editor-in-Chief for the CHiP Network journal watch. His wife, Khyati is a pediatric cardiac Electrophysiologist and they have a 9-year-old daughter. Dr. Patel is also an artist, likes music, yoga and plays badminton. His clinical areas of expertise and interests are: 1) Transcatheter therapies for Structural and Adult Congenital heart disease. 2) Complex device implantations.

Dr. Timothy Pirolli is an Assistant Professor of Surgery in the Division of Pediatric Cardiothoracic Surgery at University of Texas Southwestern Medical Center. He specializes in pediatric and adult congenital cardiac surgery. His hospital affiliations include Children’s Medical Center in Dallas, Parkland Memorial Hospital, and Clements University Hospital (UTSW).

Dr. Inga Voges, M.D. Consultant in Pediatric Cardiology, Lead Consultant Cardiovascular MRI. I trained in General Pediatrics and Pediatric Cardiology in Rostock (Germany) and Kiel (Germany) from 2002-2010 and did additional training in Adult Congenital Heart Disease (ACHD) in Kiel (Germany) which I finished in 2014. I specialized in Cardiovascular Magnetic Resonance Imaging (CMR) and have a further special interest in cardiomyopathies. Currently, I am working as a consultant pediatric and ACHD cardiologist at the University Hospital Schleswig-Holstein (Kiel, Germany) where I am responsible for the CMR imaging program in pediatric and ACHD patients and contribute to the care of patients with acquired and congenital heart disease. I received my MD from the Medical University Luebeck in 2006 (Germany) and finished my “Habilitation” (PhD equivalent; University Hospital Kiel, Germany) in 2014. Since 2016, I am the secretary of the Association for European Paediatric and Congenital Cardiology Imaging Working Group.

Dr. Gary Webb, M.D. is an Emeritus Professor of Pediatrics and Internal Medicine at the University of Cincinnati College of Medicine and,
from 2009-2016, the Director of the Adult Congenital Heart Program at Cincinnati Children’s Hospital Heart Institute. A graduate of McGill
University in Montréal, he interned at the Royal Victoria Hospital, and then trained in internal medicine and cardiology at the University of Toronto. From 1980-2004, he was co-director and then director of the Toronto Congenital Cardiac Center for Adults at Toronto General Hospital. He is a Fellow of the Royal College of Physicians and Surgeons of Canada in both internal medicine and cardiology. From 2004-2009, he was director of the Philadelphia Adult Congenital Heart Center at the University of Pennsylvania. Since 2016, he has been a consultant to Cincinnati Children’s Hospital, and has been responsible for the ACHD Learning Center, the Cardiology Fellow Testing Center, and the Congenital Heart Professionals International (CHIP) Network. Since 2017, he has resumed seeing patients on a part-time basis at the Toronto Congenital Cardiac Centre for Adults.

Wendy Whiteside, MD Wendy is Assistant Professor of Pediatrics and Associate Director of Interventional Pediatric Cardiology at the University of Michigan Congenital Heart Center, C.S. Mott Children’s Hospital. She obtained her medical degree from Albert Einstein College of Medicine in 2006 then completed pediatric residency at Children’s Hospital Oakland in Oakland, CA in 2009. She received
both her categorical and interventional pediatric cardiology training at the University of Michigan in Ann Arbor, MI. Her clinical and research interests include single ventricle physiology, transcatheter
pulmonary valves, and quality improvement within the cardiac catheterization laboratory.

About the Congenital Heart and Pediatric Cardiac Journal Watch

Congenital heart and pediatric cardiac Journal Watch was designed to make it easier for congenital heart and pediatric cardiac professionals to keep up with the literature in 6 subsections of congenital heart disease abstracts on a monthly basis: pediatric cardiology; congenital heart surgery; congenital  heart interventions; congenital/pediatric electrophysiology; fetal cardiology; and adult congenital heart disease.

We encourage your continued support as well as your valuable comments and feedback.

Learn More

Sincerely,

Dr. Gary Webb, MD and Dr. Mehul Patel
CHiP Network
Congenital Heart and Pediatic Cardiac Journal Watch Editorial Board

The Chip Network, the Congenital Heart International Professionals Network, aims to develop a single global list of all congenital and pediatric cardiac professionals.

We invite you to share this with your colleagues.