CHiP Network Congenital Heart Journal Watch – January 2020

Pediatric Cardiology Featured Articles

Pediatric Cardiology Reviews of October- December 2019 Manuscripts

 

Pediatric Cardiology Review for October-December 2019

Parental reactions, distress, and sense of coherence after prenatal versus postnatal diagnosis of complex congenital heart disease.

Bratt EL, Järvholm S, Ekman-Joelsson BM, Johannsmeyer A, Carlsson SÅ, Mattsson LÅ, Mellander M.

Cardiol Young. 2019 Sep 16:1-7. doi: 10.1017/S1047951119001781. [Epub ahead of print]

PMID: 31522698

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Take Home Points :

  • Parents with babies born with congenital heart disease have a high level of anxiety and depression than their matched control groups. There was no difference between the anxiety scores of parents with prenatal vs postnatal diagnosis.
  • Life Satisfaction was lower in the parents in the prenatal group and it decreased further during follow up testing after birth, suggesting this group remained vulnerable to poor psychological health.
  • Parents in the prenatal group had a lower sense of coherence when compared to controls and upon follow up testing continued to remain so.
  • Parents in the postnatal group scored satisfaction with the relationship significantly higher than parents in the control group. The factors underlying this are not clear but may relate to parents coming together and making their life comprehensible, manageable and meaningful.( as evidenced by an increased sense of coherence ).
  • Given the risk of adverse psychological health, efforts should focus on improving counseling and support during pregnancy for parents with a fetal diagnosis of congenital heart disease. 

Commentary from Dr. Venugopal Amula (Salt Lake City, UT), section editor of Pediatric Cardiology Journal Watch:  It is well known that parental stress during pregnancy negatively affects neonatal outcomes and can hamper infant development. In the current study, investigators from the University of Gothenburg, Sweden,  study the impact of timing of diagnosis of Congenital Heart Disease (prenatal vs postnatal ) on the psychological health of pregnant women and their partners. Specifically, depression and anxiety, sense of coherence, life satisfaction and satisfaction with partner relationship were studied. Three study groups were included those with a prenatal diagnosis of CHD in offspring (prenatal group), those with a postnatal diagnosis (post-natal group), and a group with uncomplicated pregnancies and deliveries (controls). Patients in the prenatal group were recruited after 22 completed weeks of pregnancy so as not to interfere with the decision to terminate the pregnancy ( the upper limit of GA to allow termination being 22 completed weeks in Sweden). Matching of the groups based on parental age, sex and parity and complexity of CHD was done. Previously validated instruments such as Hospital Anxiety and Depression scale, Sense of Coherence Scale, Life Satisfaction scale and Dyadic Adjustment scale were used. Testing at Time 1 included prenatal group and healthy controls. All three groups were tested at follow up (Time 2) between 2-6 months after delivery.

 

Pediatric cardiology Nov 2019

  1. Congenital Heart Disease in Low- and Lower-Middle-Income Countries: Current Status and New Opportunities.

Zühlke L, Lawrenson J, Comitis G, De Decker R, Brooks A, Fourie B, Swanson L, Hugo-Hamman C.

Curr Cardiol Rep. 2019 Nov 29;21(12):163. doi: 10.1007/s11886-019-1248-z. Review.

PMID: 31784844

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  1. Prognostic value of the preoperative neutrophil-lymphocyte ratio in patients undergoing the bidirectional Glenn procedure.

Manuel V, Miana LA, Guerreiro GP, Tenório DF, Turquetto A, Penha JG, Massoti MR, Tanamati C, Junior APF, Caneo LF, Jatene FB, Jatene MB.

J Card Surg. 2019 Nov 29. doi: 10.1111/jocs.14381. [Epub ahead of print]

PMID: 31782834

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  1. Pulmonary hypertension in paediatrics. A feasible approach to bridge the gap between real world and guidelines.

Giuseppe C, Pier Paolo B, Francesco B, Francesco M, Vassilios F, Francesco F, Francesco R.

J Matern Fetal Neonatal Med. 2019 Nov 19:1-211. doi: 10.1080/14767058.2019.1695770. [Epub ahead of print]

PMID: 31744358

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  1. Increased systemic inflammation in children with Down syndrome.

Huggard D, Kelly L, Ryan E, McGrane F, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Doherty DG, Molloy EJ.

Cytokine. 2019 Nov 27;127:154938. doi: 10.1016/j.cyto.2019.154938. [Epub ahead of print]

PMID: 31785499

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  1. Characteristics and outcomes of children with congenital heart disease needing diaphragm plication.

Foster CB, Cabrera AG, Bagdure D, Blackwelder W, Moffett BS, Holloway A, Mishcherkin V, Bhutta A.

Cardiol Young. 2019 Nov 26:1-4. doi: 10.1017/S1047951119002671. [Epub ahead of print]

PMID: 31769370

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  1. Risk Factors and Outcomes of Tetralogy of Fallot: From Fetal to Neonatal Life.

Silva JA, Neves AL, Flor-de-Lima F, Soares P, Guimarães H.

Pediatr Cardiol. 2019 Nov 25. doi: 10.1007/s00246-019-02239-4. [Epub ahead of print]

PMID: 31768578

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  1. Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile.

Wang D, Zhang Y, Jiang Y, Ye Y, Ji M, Dou Y, Chen X, Li M, Ma X, Sheng W, Huang G, Yan W; SPCC group.

BMJ Open. 2019 Nov 24;9(11):e031076. doi: 10.1136/bmjopen-2019-031076.

PMID: 31767586 Free PMC Article

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  1. Von Willebrand factor parameters as potential biomarkers for disease activity and coronary artery lesion in patients with Kawasaki disease.

Jakob A, Schachinger E, Klau S, Lehner A, Ulrich S, Stiller B, Zieger B.

Eur J Pediatr. 2019 Nov 23. doi: 10.1007/s00431-019-03513-6. [Epub ahead of print]

PMID: 31760507

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  1. Identification of a novel compound heterozygous IDUA mutation underlies Mucopolysaccharidoses type I in a Chinese pedigree.

Zhou YA, Li P, Zhang Y, Xiong Q, Li C, Zhao Z, Wang Y, Xiao H.

Mol Genet Genomic Med. 2019 Nov 23:e1058. doi: 10.1002/mgg3.1058. [Epub ahead of print]

PMID: 31758674 Free Article

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  1. Neonatal Non-compacted Cardiomyopathy: Predictors of Poor Outcome.

Rodriguez-Fanjul J, Tubio-Gómez S, Carretero Bellón JM, Bautista-Rodríguez C, de Toledo JS.

Pediatr Cardiol. 2019 Nov 23. doi: 10.1007/s00246-019-02241-w. [Epub ahead of print]

PMID: 31758211

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  1. Associations between maternal social support and stressful life event with ventricular septal defect in offspring: a case-control study.

Lyu J, Zhao K, Xia Y, Zhao A, Yin Y, Hong H, Li S.

BMC Pregnancy Childbirth. 2019 Nov 21;19(1):429. doi: 10.1186/s12884-019-2541-y.

PMID: 31752736 Free Article

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  1. Phenotypic delineation of the retinal arterial macroaneurysms with supravalvular pulmonic stenosis syndrome.

Alkuraya H, Patel N, Ibrahim N, Al Ghamdi B, Alsulaiman SM, Nowilaty SR, Abboud E, Alturki R, Alkharashi A, Eyaid W, Almasseri Z, Alzaidan H, Alotaibi MD, Abu El-Asrar AM, Alamro B, Helaby R, Elshaer A, Almontashiri NAM, Al-Hussaini AA, Alkuraya FS.

Clin Genet. 2019 Nov 15. doi: 10.1111/cge.13676. [Epub ahead of print]

PMID: 31730227

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  1. Risk Factors for Acute Rheumatic Fever: Literature Review and Protocol for a Case-Control Study in New Zealand.

Baker MG, Gurney J, Oliver J, Moreland NJ, Williamson DA, Pierse N, Wilson N, Merriman TR, Percival T, Murray C, Jackson C, Edwards R, Foster Page L, Chan Mow F, Chong A, Gribben B, Lennon D.

Int J Environ Res Public Health. 2019 Nov 15;16(22). pii: E4515. doi: 10.3390/ijerph16224515.

PMID: 31731673 Free PMC Article

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  1. Children with Congenital Heart Disease Are Active but Need to Keep Moving: A Cross-Sectional Study Using Wrist-Worn Physical Activity Trackers.

Brudy L, Hock J, Häcker AL, Meyer M, Oberhoffer R, Hager A, Ewert P, Müller J.

J Pediatr. 2019 Nov 15. pii: S0022-3476(19)31314-9. doi: 10.1016/j.jpeds.2019.09.077. [Epub ahead of print]

PMID: 31740142

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  1. ChyloBEST: Chylothorax in Infants and Nutrition with Low-Fat Breast Milk.

Neumann L, Springer T, Nieschke K, Kostelka M, Dähnert I.

Pediatr Cardiol. 2019 Nov 15. doi: 10.1007/s00246-019-02230-z. [Epub ahead of print]

PMID: 31729543

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  1. Health Related Quality of Life of Children with Congenital Heart Disease Attending at Tertiary Level Hospital.

Mishra TA, Sharma P.

J Nepal Health Res Counc. 2019 Nov 13;17(3):288-292. doi: 10.33314/jnhrc.v17i3.1789.

PMID: 31735919

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  1. Parent Perspectives on Family-Based Psychosocial Interventions for Congenital Heart Disease.

Gramszlo C, Karpyn A, Demianczyk AC, Shillingford A, Riegel E, Kazak AE, Sood E.

J Pediatr. 2019 Nov 12. pii: S0022-3476(19)31294-6. doi: 10.1016/j.jpeds.2019.09.059. [Epub ahead of print]

PMID: 31735417

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  1. Pulmonary hypertension in paediatrics. A feasible approach to bridge the gap between real world and guidelines.

Giuseppe C, Pier Paolo B, Francesco B, Francesco M, Vassilios F, Francesco F, Francesco R.

J Matern Fetal Neonatal Med. 2019 Nov 19:1-211. doi: 10.1080/14767058.2019.1695770. [Epub ahead of print]

PMID: 31744358

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  1. Capillary Malformation-Arteriovenous Malformation Combined Alagille Syndrome in a Patient With Double Gene Variations of RASA1 and NOTCH2.

Zheng Y, Peng Y, Zhang S, Li L, Peng Y, Yin Q.

Front Genet. 2019 Nov 5;10:1088. doi: 10.3389/fgene.2019.01088. eCollection 2019.

PMID: 31749841 Free PMC Article

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  1. Neonatal Risk in Children of Women With Congenital Heart Disease: A Cohort Study With Focus on Socioeconomic Status.

Kloster S, Tolstrup JS, Olsen MS, Johnsen SP, Søndergaard L, Nielsen DG, Ersbøll AK.

J Am Heart Assoc. 2019 Nov 5;8(21):e013491. doi: 10.1161/JAHA.119.013491. Epub 2019 Oct 28.

PMID: 31656122 Free Article

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  1. Improving growth of infants with congenital heart disease using a consensus-based nutritional pathway.

Marino LV, Johnson MJ, Davies NJ, Kidd CS, Fienberg J, Richens T, Bharucha T, Beattie RM, Darlington AE.

Clin Nutr. 2019 Nov 2. pii: S0261-5614(19)33124-3. doi: 10.1016/j.clnu.2019.10.031. [Epub ahead of print]

PMID: 31734051 Free Article

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  1. A multi-national trial of a direct oral anticoagulant in children with cardiac disease: Design and rationale of the Safety of ApiXaban On Pediatric Heart disease On the preventioN of Embolism (SAXOPHONE) study.

Payne RM, Burns KM, Glatz AC, Li D, Li X, Monagle P, Newburger JW, Swan EA, Wheaton O, Male C; Pediatric Heart Network Investigators.

Am Heart J. 2019 Nov;217:52-63. doi: 10.1016/j.ahj.2019.08.002. Epub 2019 Aug 9.

PMID: 31493728

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  1. Neuroimaging findings in newborns with congenital heart disease prior to surgery: an observational study.

Kelly CJ, Arulkumaran S, Tristão Pereira C, Cordero-Grande L, Hughes EJ, Teixeira RPAG, Steinweg JK, Victor S, Pushparajah K, Hajnal JV, Simpson J, Edwards AD, Rutherford MA, Counsell SJ.

Arch Dis Child. 2019 Nov;104(11):1042-1048. doi: 10.1136/archdischild-2018-314822. Epub 2019 Jun 26.

PMID: 31243012 Free PMC Article

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  1. Recommendations from the Association for European Paediatric and Congenital Cardiology for training in pulmonary hypertension.

Sallmon H, Moledina S, Albert DC, Beghetti M, Berger RMF, Bonnet D, Bukova M, Koestenberger M, Meinel K, Reinhardt Z, Tulloh RMR, de Wolf D, Hansmann G.

Cardiol Young. 2019 Nov;29(11):1323-1327. doi: 10.1017/S104795111900235X. Epub 2019 Sep 26.

PMID: 31554525

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  1. Parental reactions, distress, and sense of coherence after prenatal versus postnatal diagnosis of complex congenital heart disease.

Bratt EL, Järvholm S, Ekman-Joelsson BM, Johannsmeyer A, Carlsson SÅ, Mattsson LÅ, Mellander M.

Cardiol Young. 2019 Nov;29(11):1328-1334. doi: 10.1017/S1047951119001781. Epub 2019 Sep 16.

PMID: 31522698

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  1. Guideline implementation and early risk assessment in pulmonary arterial hypertension associated with congenital heart disease: A retrospective cohort study.

Deng X, Jin B, Li S, Li Y, Zhou H, Wu Y, Yan M, Hu Y, Qiu Q, Zhang G, Zheng X.

Clin Respir J. 2019 Nov;13(11):693-699. doi: 10.1111/crj.13076. Epub 2019 Aug 29.

PMID: 31419027

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  1. Implementation of pulse oximetry screening in a Danish maternity ward.

Havelund KW, Hulgaard M, Malberg D, Fenger-Gron J.

Dan Med J. 2019 Nov;66(11). pii: A5576.

PMID: 31686645

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  1. [Hypnosis in transesophageal echocardiography. The experience in a Pediatric Cardiology and Congenital Heart Disease Unit].

Montis S, Sirigu D, Marini A, Lai A, Setti P, Camboni M, Mura GC, Congia M, Manca D, Marini E, Merola A, Orrù L, Scano F, Stara R, Urru M, Tumbarello R.

G Ital Cardiol (Rome). 2019 Nov;20(11):651-657. doi: 10.1714/3254.32226. Italian.

PMID: 31697272

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  1. [Physiological and paraphysiological echocardiographic findings in neonatal and pediatric age].

Russo MG, Cirillo A, Rinelli G, Vairo U, Favilli S, Moreo A, Domenicucci S, Gulizia MM, Gabrielli D.

G Ital Cardiol (Rome). 2019 Nov;20(11):627-631. doi: 10.1714/3254.32223. Italian.

PMID: 31697269

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  1. Functional analysis of rare variants of GATA4 identified in Chinese patients with congenital heart defect.

Zhao Z, Zhan Y, Chen W, Ma X, Sheng W, Huang G.

Genesis. 2019 Nov;57(11-12):e23333. doi: 10.1002/dvg.23333. Epub 2019 Sep 12.

PMID: 31513339

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  1. Cardiopulmonary Rehabilitation in Children With Congenital Heart Disease.

Siaplaouras J, Apitz C.

J Cardiopulm Rehabil Prev. 2019 Nov;39(6):E35. doi: 10.1097/HCR.0000000000000487. No abstract available.

PMID: 31688514

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  1. Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children.

Wu J, Li J, Liu H, Yin J, Zhang M, Yu Z, Miao H.

J Clin Lab Anal. 2019 Nov;33(9):e22998. doi: 10.1002/jcla.22998. Epub 2019 Aug 20.

PMID: 31429492 Free PMC Article

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  1. Imaging of Pulmonary Atresia With Ventricular Septal Defect.

Abdel Razek AAK, Al-Marsafawy H, Elmansy M.

J Comput Assist Tomogr. 2019 Nov/Dec;43(6):906-911. doi: 10.1097/RCT.0000000000000938. Review.

PMID: 31738213

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  1. Neonatal Palliative Care for Complicated Cardiac Anomalies: A 10-Year Experience of an Interdisciplinary Program at a Large Tertiary Cardiac Center.

Haxel C, Glickstein J, Parravicini E.

J Pediatr. 2019 Nov;214:79-88. doi: 10.1016/j.jpeds.2019.07.044.

PMID: 31655705

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  1. 50 Years Ago in TheJournal ofPediatrics: The Prevalence of Congenital Heart Disease in United States College Freshmen, 1956-1965.

Zaban NB, Przybylowski LF, Schamberger MS.

J Pediatr. 2019 Nov;214:33. doi: 10.1016/j.jpeds.2019.05.015. No abstract available.

PMID: 31655702

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  1. Pediatric Hemoptysis without Bronchiectasis or Cardiac Disease: Etiology, Recurrence, and Mortality.

Chiel L, Welsh S, Andren K, Mecklosky J, Alexander PMA, Casey A, Fishman MP.

J Pediatr. 2019 Nov;214:66-70. doi: 10.1016/j.jpeds.2019.07.049. Epub 2019 Sep 17.

PMID: 31540762

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  1. The Impact of Neurobehavior on Feeding Outcomes in Neonates with Congenital Heart Disease.

Gakenheimer-Smith L, Glotzbach K, Ou Z, Presson AP, Puchalski M, Jones C, Lambert L, Delgado-Corcoran C, Eckhauser A, Miller T.

J Pediatr. 2019 Nov;214:71-78.e2. doi: 10.1016/j.jpeds.2019.06.047. Epub 2019 Aug 8.

PMID: 31402138

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  1. Renal replacement therapy in the pediatric cardiac intensive care unit.

Hames DL, Ferguson MA, Kaza AK, Rajagopal S, Thiagarajan RR, Teele SA, Salvin JW.

J Thorac Cardiovasc Surg. 2019 Nov;158(5):1446-1455. doi: 10.1016/j.jtcvs.2019.06.061. Epub 2019 Jul 10.

PMID: 31395365

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  1. Pulmonary Insufficiency: Advantage of Pulmonary Regurgitation Volume Versus Pulmonary Regurgitation Fraction in a Congenital Heart Disease Mixed Population.

Secchi F, Chessa M, Petrini M, Monti CB, Alì M, Cannaò PM, Di Leo G, Sardanelli F.

J Thorac Imaging. 2019 Nov;34(6):380-386. doi: 10.1097/RTI.0000000000000400.

PMID: 30870306

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  1. APRISMA-compliant systematic review and meta-analysis determining the association of miRNA polymorphisms and risk of congenital heart disease.

Li XY, Chen K, Lv ZT.

Medicine (Baltimore). 2019 Nov;98(45):e17653. doi: 10.1097/MD.0000000000017653.

PMID: 31702616 Free PMC Article

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  1. Early Integration of Palliative Care in Families of Children with Single Ventricle Congenital Heart Defects: A Quality Improvement Project to Enhance Family Support.

Davis JAM, Bass A, Humphrey L, Texter K, Garee A.

Pediatr Cardiol. 2019 Nov 1. doi: 10.1007/s00246-019-02231-y. [Epub ahead of print]

PMID: 31676955

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  1. Hospital-Acquired Pressure Injuries in Children With Congenital Heart Disease: Prevalence and Associated Factors.

Kulik LA, Hasbani NR, Stellar JJ, Quigley SM, Shelley SS, Wypij D, Curley MAQ; for Braden QD Study Group.

Pediatr Crit Care Med. 2019 Nov;20(11):1048-1056. doi: 10.1097/PCC.0000000000002077.

PMID: 31385861

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  1. Sub-acute neonatal hemochromatosis in an infant with hypoplastic left heart syndrome on ventricular assist device awaiting transplantation.

Tadros HJ, Gupta D, Childress M, Beasley G, Rubrecht AE, Shenoy A, Philip J, Bleiweis MS, Machado DS.

Pediatr Transplant. 2019 Nov;23(7):e13567. doi: 10.1111/petr.13567. Epub 2019 Aug 13.

PMID: 31407854

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  1. Autism and Congenital Heart Disease: Evidence and Unresolved Questions.

Calderon J, Bellinger DC, Newburger JW.

Pediatrics. 2019 Nov;144(5). pii: e20192752. doi: 10.1542/peds.2019-2752. Epub 2019 Oct 10. No abstract available.

PMID: 31601612

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  1. Congenital Heart Disease and Autism: A Case-Control Study.

Sigmon ER, Kelleman M, Susi A, Nylund CM, Oster ME.

Pediatrics. 2019 Nov;144(5). pii: e20184114. doi: 10.1542/peds.2018-4114. Epub 2019 Oct 10.

PMID: 31601611

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  1. Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of conotruncal heart defects.

Wen H, Zhang R, Li Y, Qian H, Yan Z, Chen Y, Li G.

Per Med. 2019 Nov;16(6):449-455. doi: 10.2217/pme-2018-0154. Epub 2019 Nov 6.

PMID: 31691635

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  1. Detecting Critical Congenital Heart Disease in Nevada.

Evans WN, Acherman RJ, Ciccolo ML, Lehoux J, Rothman A, Galindo A.

World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):702-706. doi: 10.1177/2150135119873847.

PMID: 31701835

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  1. Quality Improvement Basics: A Crash Course for Pediatric Cardiac Care.

Bates KE, Connor J, Chanani NK, McLellan MC, McCormick A, Smith-Parrish M, Moga MA.

World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):733-741. doi: 10.1177/2150135119881393. Epub 2019 Oct 30.

PMID: 31663842

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  1. Neurodevelopmental Outcomes Among Children With Congenital Heart Disease: At-Risk Populations and Modifiable Risk Factors.

Ryan KR, Jones MB, Allen KY, Marino BS, Casey F, Wernovsky G, Lisanti AJ.

World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):750-758. doi: 10.1177/2150135119878702. Epub 2019 Oct 28.

PMID: 31658880

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  1. Pediatric Myocarditis Protocol: An Algorithm for Early Identification and Management with Retrospective Analysis for Validation.

Howard A, Hasan A, Brownlee J, Mehmood N, Ali M, Mehta S, Fergie J.

Pediatr Cardiol. 2019 Nov 30. doi: 10.1007/s00246-019-02258-1. [Epub ahead of print]

PMID: 31786619

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  1. Current evaluation and management of plastic bronchitis in the pediatric population.

Li Y, Williams RJ, Dombrowski ND, Watters K, Daly KP, Irace AL, Visner GA, Rahbar R, Fynn-Thompson F.

Int J Pediatr Otorhinolaryngol. 2019 Nov 29;130:109799. doi: 10.1016/j.ijporl.2019.109799. [Epub ahead of print]

PMID: 31812839

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Select item 31795342

 

  1. Case-matched Comparison of Cardiovascular Outcome in Loeys-Dietz Syndrome versus Marfan Syndrome.

Mühlstädt K, De Backer J, von Kodolitsch Y, Kutsche K, Muiño Mosquera L, Brickwedel J, Girdauskas E, Mir TS, Mahlmann A, Tsilimparis N, Staebler A, Schoof L, Seidel H, Berger J, Bernhardt AM, Blankenberg S, Kölbel T, Detter C, Szöcs K, Kaemmerer H.

J Clin Med. 2019 Nov 29;8(12). pii: E2079. doi: 10.3390/jcm8122079.

PMID: 31795342 Free Article

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  1. Management of Pulmonary Arterial Hypertension in the Pediatric Patient.

Ezekian JE, Hill KD.

Curr Cardiol Rep. 2019 Nov 28;21(12):162. doi: 10.1007/s11886-019-1229-2. Review.

PMID: 31781972

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Select item 31777971

 

  1. Predictive value of serum procalcitonin for both initial and repeated immunoglobulin resistance in Kawasaki disease: a prospective cohort study.

Shao S, Luo C, Zhou K, Hua Y, Wu M, Liu L, Liu X, Wang C.

Pediatr Rheumatol Online J. 2019 Nov 27;17(1):78. doi: 10.1186/s12969-019-0379-5.

PMID: 31775782 Free PMC Article

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Select item 31769697

 

  1. Repairing transposition of the great arteries: history of the challenge.

Mazurak M, Kusa J.

Arch Dis Child. 2019 Nov 26. pii: archdischild-2019-318044. doi: 10.1136/archdischild-2019-318044. [Epub ahead of print] No abstract available.

PMID: 31771944

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Select item 31769372

 

  1. Tissue characterisation and myocardial mechanics using cardiac MRI in children with hypertrophic cardiomyopathy.

Sunthankar S, Parra DA, George-Durrett K, Crum K, Chew JD, Christensen J, Raucci FJ, Xu M, Slaughter JC, Soslow JH.

Cardiol Young. 2019 Nov 26:1-9. doi: 10.1017/S1047951119002397. [Epub ahead of print]

PMID: 31769372

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Select item 31769370

 

  1. Characteristics and outcomes of children with congenital heart disease needing diaphragm plication.

Foster CB, Cabrera AG, Bagdure D, Blackwelder W, Moffett BS, Holloway A, Mishcherkin V, Bhutta A.

Cardiol Young. 2019 Nov 26:1-4. doi: 10.1017/S1047951119002671. [Epub ahead of print]

PMID: 31769370

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Select item 31767043

 

  1. Unicuspid Aortic Valve: Demographics, Comorbidities, Echocardiographic Features, and Long-Term Outcomes.

Slostad BD, Witt CM, O’Leary PW, Maleszewski JJ, Scott CG, Dearani JA, Pellikka PA.

Circulation. 2019 Nov 26;140(22):1853-1855. doi: 10.1161/CIRCULATIONAHA.119.041835. Epub 2019 Nov 25. No abstract available.

PMID: 31765262

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Select item 31768523

 

  1. Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources.

Geva A, Abman SH, Manzi SF, Ivy DD, Mullen MP, Griffin J, Lin C, Savova GK, Mandl KD.

J Am Med Inform Assoc. 2019 Nov 26. pii: ocz194. doi: 10.1093/jamia/ocz194. [Epub ahead of print]

PMID: 31769835

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Select item 31773636

 

  1. Point-of-care ultrasound for peripherally inserted central catheter monitoring: a pilot study.

Motz P, Von Saint Andre Von Arnim A, Iyer RS, Chabra S, Likes M, Dighe M.

J Perinat Med. 2019 Nov 26;47(9):991-996. doi: 10.1515/jpm-2019-0198.

PMID: 31605580

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Select item 31770781

 

  1. Pediatric systemic lupus erythematosus patients in South Africa have high prevalence and severity of cardiac and vascular manifestations.

Harrison MJ, Zühlke LJ, Lewandowski LB, Scott C.

Pediatr Rheumatol Online J. 2019 Nov 26;17(1):76. doi: 10.1186/s12969-019-0382-x.

PMID: 31771606 Free PMC Article

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Select item 31760959

 

  1. Late manifestation coarctation of the aorta in a premature infant 4-month post-percutaneous device closure of a patent ductus arteriosus.

Serrano RM, Rodefeld MD, Alexy R.

Cardiol Young. 2019 Nov 25:1-3. doi: 10.1017/S1047951119002555. [Epub ahead of print]

PMID: 31760959

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Select item 31778856

 

  1. Echocardiographic predictors of acute kidney injury in neonates with a patent ductus arteriosus.

Coffman Z, Steflik D, Chowdhury SM, Twombley K, Buckley J.

J Perinatol. 2019 Nov 25. doi: 10.1038/s41372-019-0560-1. [Epub ahead of print]

PMID: 31767977

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Select item 31678091

 

  1. The evaluation of right ventricular systolic function in patients with repaired Tetralogy of Fallot by conventional echocardiographic methods and speckle tracking echocardiography: Compared with the gold standard cardiac mangenetic resonance.

Kavurt AV, Paç FA, Koca S, Mutlu Mıhçıoğlu A, Yiğit H.

Echocardiography. 2019 Nov 22. doi: 10.1111/echo.14532. [Epub ahead of print]

PMID: 31755582

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Select item 31758312

 

  1. Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources.

Geva A, Abman SH, Manzi SF, Ivy DD, Mullen MP, Griffin J, Lin C, Savova GK, Mandl KD.

J Am Med Inform Assoc. 2019 Nov 26. pii: ocz194. doi: 10.1093/jamia/ocz194. [Epub ahead of print]

PMID: 31769835

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Select item 31773636

 

  1. Valve Replacement in Children with Single Ventricle Physiology.

Alshami N, Sarvestani AL, Thomas AS, St Louis J, Kochilas L, Raghuveer G.

Pediatr Cardiol. 2019 Nov 16. doi: 10.1007/s00246-019-02234-9. [Epub ahead of print]

PMID: 31734750

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Select item 31732764

 

  1. Comparison of the characteristics at diagnosis and treatment of children with heterozygous familial hypercholesterolaemia (FH) from eight European countries.

Ramaswami U, Futema M, Bogsrud MP, Holven KB, Roeters van Lennep J, Wiegman A, Descamps OS, Vrablik M, Freiberger T, Dieplinger H, Greber-Platzer S, Hanauer-Mader G, Bourbon M, Drogari E, Humphries SE.

Atherosclerosis. 2019 Nov 15;292:178-187. doi: 10.1016/j.atherosclerosis.2019.11.012. [Epub ahead of print]

PMID: 31809987 Free Article

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Select item 31729309

 

  1. Clinical Significance of Central Venous Pressure During Exercise After Fontan Procedure.

Asagai S, Inai K, Shimada E, Harada G, Sugiyama H.

Pediatr Cardiol. 2019 Nov 11. doi: 10.1007/s00246-019-02249-2. [Epub ahead of print]

PMID: 31712861

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Select item 31712860

 

  1. Evidence of Systemic Absorption of Enteral Budesonide in Patients with Fontan-Associated Protein-Losing Enteropathy.

Roberts RO 3rd, Di Maria MV, Brigham D, Hsu S.

Pediatr Cardiol. 2019 Nov 9. doi: 10.1007/s00246-019-02248-3. [Epub ahead of print]

PMID: 31707491

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Select item 31707490

 

  1. Anti-thrombosis management of patients with Kawasaki disease: Results from an international survey.

Dionne A, Dahdah N, Singh-Grewal D, Burgner DP, Newburger JW, de Ferranti SD.

Int J Cardiol. 2019 Nov 2. pii: S0167-5273(19)34308-6. doi: 10.1016/j.ijcard.2019.10.045. [Epub ahead of print]

PMID: 31753581

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Select item 31679056

 

  1. Trends and presentation patterns of acute rheumatic fever hospitalisations in the United States.

Bradley-Hewitt T, Longenecker CT, Nkomo V, Osborne W, Sable C, Scheel A, Zühlke L, Watkins D, Beaton A.

Cardiol Young. 2019 Nov;29(11):1387-1390. doi: 10.1017/S1047951119002270. Epub 2019 Oct 1.

PMID: 31571555

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Select item 31566150

 

  1. The effect of combined therapy for treatment of monotherapy-resistant PDA in preterm infants.

Yurttutan S, Bozkaya A, Hüdayioglu F, Oncel MY.

J Matern Fetal Neonatal Med. 2019 Nov;32(21):3662-3665. doi: 10.1080/14767058.2018.1481043. Epub 2018 Jun 19.

PMID: 29921134

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ACHD Featured Articles in association with ISACHD

ACHD Cardiology Reviews of October-December 2019 Manuscripts

 

Adult Congenital Heart Reviews of October – December 2019 Manuscripts provided by ISACHD

 Reduced biventricular contractility during exercise in adults with small, unrepaired ventricular septal defects: an echocardiographic study.

Maagaard M, Heiberg J, Redington AN, Hjortdal VE.

Eur J Cardiothorac Surg. 2019 Oct 18. pii: ezz278. doi: 10.1093/ejcts/ezz278. [Epub ahead of print]

PMID: 31625565

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Select item 31625562

 Take Home Points: 

  • In young adults with small unrepaired ventricular septal defects (VSD), exercise capacity is diminished when compared with healthy controls, which can be explained by reduced biventricular contractility at rest and during exercise.
  • Specifically, tissue Doppler parameters of left ventricle (LV) systolic function, including Isovolumetric acceleration (IVA), are diminished both at rest and during exercise in VSD patients when compared with healthy controls. Thus, LV contractile reserve is progressively decreased at higher workloads in VSD patient.
  • Patients with small unrepaired VSD are at increased risk of long-term complications and should be followed in adult congenital heart centers.

Commentary from Dr. Maan Jokhadar (Atlanta GA), section editor of ACHD Journal Watch: Recent studies have demonstrated reduced exercise capacity in young patients with unrepaired small ventricular septal defects (shunt fraction < 1.5) and this is thought to be due to ventricular dysfunction from a small shunt over a prolonged period of time.

Ventricular force – frequency relationships can be studied noninvasively using tissue Doppler techniques to reflect the dynamic myocardial response to exercise.

This elegant study was conducted by Dr. Maagaard and colleagues from Aarhus, Denmark in collaboration with Dr. Redington in Cincinnati, OH, USA. They studied 34 unrepaired VSD patients and 28 healthy controls between the ages of 18 and 40. In the VSD group, 9 were muscular and 23 were perimembranous. All participants had normal resting ejection fraction, tricuspid regurgitation velocity less than 2.8 cm/sec, normal right atrial pressure, and no measurable aortic insufficiency. The average age was 27 years and baseline characteristics were comparable in the patient and control group, including height, weight, gender, body mass index, heart rate, blood pressure, as well as comparable daily exercise levels.

All patients in the small VSD group had isolated VSD without prior surgical intervention and no associated congenital heart disease, arrhythmia, or syndrome. The median shunt fraction was 1.2.

All participants had bicycle exercise echocardiogram with longitudinal incremental tissue Doppler imaging with workload increased until exhaustion. Tissue Doppler measurements were obtained in the apical 4 chamber from the basal septum and basal free walls of the LV and RV.

At baseline, IVA was lower in VSD patients compared with controls in the septum, LV, and RV.  LV and RV peak S’ was also lower in VSD patients. However, septal S’, E’, and A’ were similar between VSD patients and controls.

During supine bicycle ergometry, force-frequency relationship curves of IVA in VSD patients were lower than controls in the septum, RV, and LV.  This difference increased with intensifying workload. IVV and S’ of the RV, LV, and septum were also lower in VSD patients during exercise.

Smaller shunts had higher LV IVA but this inverse relationship was not true for the septum or RV. Higher RV S’ correlated with better exercise capacity in VSD patients but not in controls.

These findings may be explained by the increased left ventricle volume loading that occurs, even with small shunts over a long period of time. Clearly, even small shunts may be hemodynamically significant in the long run because of the increased LV volume load, left atrial dilation, and amplification of diastolic dysfunction with age. Though a lower threshold for VSD closure could potentially mitigate or avoid the adverse changes associated with small shunts, additional studies are needed before such a conclusion can be reached. However, this study does bolster the argument that unrepaired VSD patients should be followed by a specialized center for adult congenital patients.

This important study adds to the growing body of literature regarding the long-term hemodynamic consequences of unrepaired VSD and increases our understanding in this area.

Tissue Doppler Parameters during systole and diastole

AT: Acceleration time (sec)

IVV: Isovolumetric velocity (cm/sec)

IVA: Isovolumetric acceleration (cm/sec2)
IVA = IVV/AT (cm/sec2)

Peak S’ velocity (cm/sec)

IVCT: Isovolumetric contraction

IVRT: Isovolumetric relaxation

E’: Early relaxation

A’: Associated with atrial contraction

ET: ejection time

 

Outcomes in adults with congenital heart disease and heterotaxy syndrome: A single-center experience.

Broda CR, Salciccioli KB, Lopez KN, Ermis PR, Moodie DS, Dickerson HA.

Congenit Heart Dis. 2019 Oct 16. doi: 10.1111/chd.12856. [Epub ahead of print]

PMID: 31617655

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Select item 31578117

Take Home Points:

  • First study to assess clinical outcomes in adult patients with heterotaxy syndrome and CHD.
  • The risk for early death, transplantation and co-morbidities remains high.
  • Median survival of 54% at age 40.
  • No congenital anatomic factors (ventricular status or HS type) were associated with reduced survival.
  • Heart failure portends a worse prognosis.
  • Nearly all patients had developed tachyarrythmias by age 50.
  • 20% of patients experienced cerebrovascular accidents at point of last follow-up.
  • In patients born after January 1985, intervention, including Fontan completion occurred at an earlier age.

Commentary from Dr. Blanche Cupido (Cape Town, South Africa), section editor of ACHD Journal Watch:   Heterotaxy syndrome is a condition characterized by the abnormal lateral arrangement of thoraco-abdominal organs, and frequently associated with complex congenital heart disease (CHD). Even in the contemporary era, morbidity and mortality remains high. Very little is known about this condition relating to CHD in adults with data currently being extrapolated from paediatric data.

This is a single tertiary center (Texas, US) retrospective folder review of adult patients between 1968 and 2018. They aimed to describe the sociodemographics and clinical outcomes in adult patients with heterotaxy syndrome and congenital heart disease.

Patients were excluded if they had situs inversus totalis, or without thoraco-abdominal laterality defect. The group was then subdivided based on splenic anatomy. A total of 62 patients met the inclusion criteria.

Of the 62 patients included, 29% (n=18) had heterotaxy syndrome with polysplenia (HS-PS), 46.7% (n=29) had heterotaxy syndrome with asplenia (HS-AS). The remaining patients had insufficient data to define splenic anatomy. The median age of the cohort was 22.7 years and 41.9% were female.  Twelve (19.3%) were transplanted or dead – average age of this subgroup was 28.8 years. Three men had fathered children and one female with a Fontan circulation successfully carried a pregnancy to term.

Thirty-six interventions occurred in 24 patients after age 18 – 16 were cardiac catheterization lab interventions (angioplasty or stenting, device or coil placement, pericardiocentesis, Fontan fenestration, electrophysiology procedures). Eighteen surgical procedures occurred – Epicardial pacing, pulmonary artery plication/augmentation, Maze procedure, AV valve preplacement, Fontan conversion and heart transplant.

Forty-three patients had single ventricles of which 71% had Fontan palliations.

Twelve deaths occurred in total, 10 were pre-transplant. The overall transplant-free survival was 98.1% at age 20, 83.5% at age 30 and 54.2% at age 40 years. (Figure 1 below). Of all parameters, only systemic outflow obstruction neared statistical significance as a predictor for poor outcome. Neither ventricular status, nor HS type predicted survival disadvantage.

 

Heart failure was seen in 29.8% (n=17/57). Those with heart failure by age 18 were more likely to die or receive transplantation with time to outcome of 2.6 years. Heart failure survival was 80.8%,58.7% and 31.1% at 20, 30 and 40 years respectively. (See figure 2 below)

By age 18, 46.2% had no arrythmia, 25% had experienced tachyarrythmias, 17.3% had bradyarrhythmia and 11.5% experienced both tachy-and bradyarrythmias. Bradycardia-free survival was 33% at age 40. (Figure 3 below).  Bradycardia was not associated with a transplant-free survival disadvantage compared to no arrythmia.

Tachycardia proved a survival disadvantage with a HR 6.48 (95% CI 1.41-29.75, p=0.016). The median age of tachycardia-free survival was 54%, 29.2% and  19.5% at 20,30 and 40 years respectively (Figure 3).

 

Cerebrovascular accidents (CVA) occurred in 22.4% of patients (n=13), 7 occurring before the age of age 18. CVA was associated with transplant-free survival disadvantage (HR 7.97, 95% CI 1.93-32.99, p=0.004). CVA free survival was 84.3%, 54.2% and 40.6% at 20,30 and 40 years respectively (See Figure 4)

 

Patients were stratified by ‘era’: Early era included those born before age January 1985, and the late era were those born after January 1985. Late era patients had earlier median age of Fontan completion (6.3 vs 15 years, p=0.002).

 

All-cause mortality and survival in adults with 22q11.2 deletion syndrome.

Van L, Heung T, Graffi J, Ng E, Malecki S, Van Mil S, Boot E, Corral M, Chow EWC, Hodgkinson KA, Silversides C, Bassett AS.

Genet Med. 2019 Oct;21(10):2328-2335. doi: 10.1038/s41436-019-0509-y. Epub 2019 Apr 5.

PMID: 30948858 Free PMC Article

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Select item 31315938

Take Home Points:

  • 2 deletion is the most common microdeletion syndrome and frequently encountered in patients with congenital heart disease – particularly conotruncal anomalies.
  • Little is known about the longer-term survival of adult patients with 22q11.2 deletion syndrome.
  • This was a retrospective review of 309 adults with 22q11.2 deletion syndrome and their 1014 unaffected parents/siblings.
  • 2 deletion syndrome is associated with almost 9x independent risk of mortality compared to siblings without 22q11.2. (HR 8.86, 95% CI 2.87-27.37).
  • Of the patients with 22q11.2 deletion there were 31 deaths at a median age of 46 years (range 18 -69 years).
  • As one would expect, patients with ‘major ‘congenital heart disease had shorter survival than patients with non-major congenital heart disease.
  • Probability of survival of patients with 22q11.2 and major congenital heart disease to live to age 40 and 50 years was approximately 82% and 63% vs 98% and 85% in patients without major congenital heart disease.

Commentary from Dr. Damien Cullington (Liverpool, UK), section editor of ACHD Journal Watch:   22q11.2 deletion syndrome is thought to be inherited in 1 in 3000-4000 live births. Penetrance is very high but with wide phenotypic variability. There has been little investigation of the importance of 22q11.2 deletion in adults and this retrospective analysis sought to address what implications 22q11.2 has on survival in affected subjects compared to their siblings/parents.

 Patient demographics and outcomes

Patients were identified from a specialty clinic for adults with 22q11.2, via referrals or screening of patients with congenital heart disease (CHD). Over four fifths of patients were Caucasian (n=260) and 52% (n=161) were women. 469 siblings and 545 parents without 22q11.2 were enrolled as comparators. ‘Major’ congenital heart disease (n=112) was defined as persons with at least moderate complexity CHD, most of whom had tetralogy of Fallot (n=80). 309 subjects >17 years old with 22q11.2 deletion agreed to participate – of these, just over a third (n=112) had ‘major’ CHD.

The primary outcome measure was all cause mortality. Medical records and postmortem studies were reviewed to establish cause of death. Follow up was for a relatively modest median period of 5.3 years (range 0.1-21.5 years). During follow up, 31 subjects with 22q11.2 deletion died at a median age of 46 years old (range 18-69 years) – mostly resulting from cardiac causes (n=22) (Table 1). In comparison, 6 subjects without 22q11.2 deletion died at a median age of 58 years old (range 24-83 years old).

Controlling for other significant co-variables (such as the presence of major CHD), there was an independent relationship between survival and presence of a 22q11.2 microdeletion (Table 2).  Subjects with 22q11.2 deletion had worse survival if they had ‘major’ CHD versus ‘non-major’ CHD (Figure 1).

Table 1 Cause of death in 31 adults with 22q11.2 deletion syndrome and relationship to CHD complexity

 

Table 2 Cox regression models for mortality risk in 309 adults with 22q11.2 deletion syndrome

 

 Figure 1

 

Conclusions

 This analysis is reported to be the largest study of adult patients with 22q11.2 deletion to assess longer term survival compared to siblings and their parents not known to have 22q11.2 deletion. 22q11.2 microdeletion is a significant, independent risk factor for shorter survival. There is interesting, emerging data that rare, biallelic pathogenic variants of the TANGO2 gene within the 22q11.2 region may be associated with a more ‘malignant’ phenotype connected to sudden cardiac death and unexpected death in epilepsy. As one may expect, subjects with a 22q11.2 deletion plus major CHD had worse survival than those with milder forms of CHD.

Larger cohorts with longer term follow up is required to gather a more complete picture of the significance of 22q11.2 deletion syndrome in relation to survival. Compared to earlier analyses, median age of death in patients with 22q11.2 appears to be increasing which is reassuring.

 

Exercise Capacity in Asymptomatic Adult Patients Treated for Coarctation of the Aorta.

Dijkema EJ, Sieswerda GT, Breur JMPJ, Haas F, Slieker MG, Takken T.

Pediatr Cardiol. 2019 Oct;40(7):1488-1493. doi: 10.1007/s00246-019-02173-5. Epub 2019 Aug 7.

PMID: 31392380 Free PMC Article

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Select item 31367952

 Take Home Points: 

  • Exercise capacity was normal in a small group of adults > 20 years post repair of coarctation of the aorta.
  • Resting hypertension was present is 59 % (13/22) while exercise-induced hypertension was detected in 82 % (18/22).
  • Amongst normotensive subjects, exercise-induced hypertension occurred in 78 % (7/9).
  • Surveillance of exercise-induced hypertension with cardiopulmonary exercise testing as a precursor to chronic hypertension can be considered for its early detection.

Commentary from Dr. Timothy Roberts (Melbourne, Australia), section editor of ACHD Journal Watch:   Exercise capacity is reduced in adults with congenital heart disease (CHD), although those with repaired coarctation of the aorta (CoA) are thought to have the least – if any – impairment relative to other forms of complex CHD. Meanwhile hypertension remains a lifelong risk in repaired CoA, due to reduced aortic compliance, impaired baroceptor function, and abnormal wall-shear stress dynamics. Isolated exercise-induced hypertension may be a predictor for the future development of chronic hypertension.

The aims of this singe centre prospective study were to assess (1) exercise capacity, and (2) blood pressure response in adults with repaired CoA in relation to left ventricular and vascular function.

Study participation involved cardiopulmonary exercise testing (CPET) and cardiac MRI. Inclusion criteria were a history a CoA with primary treatment (surgical or balloon angioplasty without stenting) performed between ages 3 months to 16 years, and more than 10 years of follow-up. Exclusion criteria were isthmus or aortic arch hypoplasia, and severe associated CHD lesions. A ‘control group’ for exercise data was constructed using a large Dutch database.

A total of 72 patients met criteria, of which only 22 (31 %) agreed to participate. Patient demographics, and CPET results are shown in the tables below:

Exercise capacity was normal (VO2peak 41.7 +/- 12 ml/kg/min) in the CoA cohort. Exercise-induced hypertension was common (82 %), and of the 9 normotensive subjects, 7 (78 %) demonstrated exercise-induced hypertension. Peak exercise blood pressure was correlated to LV mass, 24-hour ambulatory systolic blood pressure, and systemic hypertension. Multiple regression analysis was attempted to identify predictors of VO2peak and not surprisingly identified male sex and age as significant predictors; a number of additional factors were included but the small sample size would make it highly unlikely to find additional significant associations (whilst being statistically inappropriate).

This study is limited by the small sample size, low recruitment rate, inevitable risk for selection bias in an exercise-based study, and the absence of a true control cohort. Nevertheless, it does demonstrate a large proportion of normotensive repaired CoA subjects to display exercise-induced hypertension. Although the significance of such a finding remains debated, these patients may benefit from more frequent blood pressure assessments to enable earlier detection of chronic hypertension. Exercise testing to assess for exercise-induced hypertension carries a Class IIb recommendation in the 2018 AHA/ACC Guidelines for the Management of Adults With Congenital Heart Disease.

 

ACHD Nov 2019

  1. Long-Term Quality of Life Outcomes in Adult Survivors after Anomalous Pulmonary Venous Drainage Repair.

Yong MS, Zhu MZL, Huang L, Griffiths S, Brink J, Brizard CP, d’Udekem Y, Konstantinov IE.

Ann Thorac Surg. 2019 Nov 30. pii: S0003-4975(19)31818-1. doi: 10.1016/j.athoracsur.2019.10.030. [Epub ahead of print]

PMID: 31794738

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Select item 31784844

 

  1. Case-matched Comparison of Cardiovascular Outcome in Loeys-Dietz Syndrome versus Marfan Syndrome.

Mühlstädt K, De Backer J, von Kodolitsch Y, Kutsche K, Muiño Mosquera L, Brickwedel J, Girdauskas E, Mir TS, Mahlmann A, Tsilimparis N, Staebler A, Schoof L, Seidel H, Berger J, Bernhardt AM, Blankenberg S, Kölbel T, Detter C, Szöcs K, Kaemmerer H.

J Clin Med. 2019 Nov 29;8(12). pii: E2079. doi: 10.3390/jcm8122079.

PMID: 31795342 Free Article

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Select item 31781932

 

  1. 3. NOACs in adult congenital heart disease – Still limited experience.

Dellborg M, Mandalenakis Z.

Int J Cardiol. 2019 Nov 19. pii: S0167-5273(19)34897-1. doi: 10.1016/j.ijcard.2019.11.117. [Epub ahead of print] No abstract available.

PMID: 31767386

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Select item 31746147

 

  1. Isolated peripheral pulmonary stenosis in Takayasu arteritis.

Alizadehasl A, Saedi S, Ganji H, Pourafkari L.

Int J Rheum Dis. 2019 Nov 19. doi: 10.1111/1756-185X.13742. [Epub ahead of print]

PMID: 31746147

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Select item 31726960

 

  1. Outcomes of Multi-Organ Transplant in Adult Patients With Congenital Heart Disease.

Wong K, Tecson K, Cedars A.

J Am Heart Assoc. 2019 Nov 19;8(22):e014088. doi: 10.1161/JAHA.119.014088. Epub 2019 Nov 13.

PMID: 31718438 Free Article

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  1. Comment on: Direct oral anticoagulants in adults with congenital heart disease – A single centre study.

Turgay Yıldırım Ö, Aydın F, Hüseyinoğlu Aydın A, Akşit E.

Int J Cardiol. 2019 Nov 27. pii: S0167-5273(19)35200-3. doi: 10.1016/j.ijcard.2019.11.142. [Epub ahead of print] No abstract available.

PMID: 31806279

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Select item 31769370

 

  1. Anxiety and Depression in Adults with Congenital Heart Disease: When to Suspect and How to Refer.

Roseman A, Kovacs AH.

Curr Cardiol Rep. 2019 Nov 22;21(11):145. doi: 10.1007/s11886-019-1237-2. Review.

PMID: 31758344

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Select item 31758312

 

  1. Development of a transition program for adolescents with congenital heart disease.

de Hosson M, De Backer J, De Wolf D, De Groote K, Demulier L, Mels S, Vandekerckhove K, Goossens E.

Eur J Pediatr. 2019 Nov 22. doi: 10.1007/s00431-019-03515-4. [Epub ahead of print]

PMID: 31758312

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Select item 31723115

 

  1. Reference values for mid-diastolic right ventricular volume in population referred for cardiac computed tomography: An additional diagnostic value to cardiac computed tomography.

Massalha S, Almufleh A, Walpot J, Ratnayake I, Qureshi R, Abbass T, Pena E, Inacio J, Rybicki FJ, Small G, Crean A, Chow BJW.

J Cardiovasc Comput Tomogr. 2019 Nov 21. pii: S1934-5925(19)30162-5. doi: 10.1016/j.jcct.2019.11.003. [Epub ahead of print]

PMID: 31787590

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Select item 31766426

 

  1. Congenital Heart Disease and the Liver.

Hilscher MB, Kamath PS.

Clin Liver Dis (Hoboken). 2019 Nov 6;14(4):138-141. doi: 10.1002/cld.828. eCollection 2019 Oct. Review. No abstract available.

PMID: 31709041 Free PMC Article

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Select item 31692272

 

 

  1. Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease.

Konno R, Tatebe S, Sugimura K, Satoh K, Aoki T, Miura M, Suzuki H, Yamamoto S, Sato H, Terui Y, Miyata S, Adachi O, Kimura M, Saiki Y, Shimokawa H.

PLoS One. 2019 Nov 19;14(11):e0225403. doi: 10.1371/journal.pone.0225403. eCollection 2019.

PMID: 31743362 Free PMC Article

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Select item 31742724

 

  1. Risk of coronary artery disease in adults with congenital heart disease: A comparison with the general population.

Kuijpers JM, Vaartjes I, Bokma JP, van Melle JP, Sieswerda GT, Konings TC, Boo MB, van der Bilt I, Voogel B, Zwinderman AH, Mulder BJM, Bouma BJ.

Int J Cardiol. 2019 Nov 18. pii: S0167-5273(19)32104-7. doi: 10.1016/j.ijcard.2019.11.114. [Epub ahead of print]

PMID: 31767384

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Select item 31812566

 

  1. Severe pulmonary hypertension and reduced right ventricle systolic function associated with maternal mortality in pregnant uncorrected congenital heart diseases.

Hartopo AB, Anggrahini DW, Nurdiati DS, Emoto N, Dinarti LK.

Pulm Circ. 2019 Nov 18;9(4):2045894019884516. doi: 10.1177/2045894019884516. eCollection 2019 Oct-Dec.

PMID: 31798834 Free PMC Article

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Select item 31736331

 

  1. FUELing the Search for Medical Therapies in Late Fontan Failure.

Gewillig M, Van De Bruaene A.

Circulation. 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044512. [Epub ahead of print]

PMID: 31736331

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Select item 31738929

 

  1. Results of an Expert Consensus Survey on the Treatment of Pulmonary Arterial Hypertension With Oral Prostacyclin Pathway Agents.

McLaughlin VV, Channick R, De Marco T, Farber HW, Gaine S, Galié N, Krasuski RA, Preston I, Souza R, Coghlan JG, Frantz RP, Hemnes A, Kim NH, Lang IM, Langleben D, Li M, Sitbon O, Tapson V, Frost A.

Chest. 2019 Nov 16. pii: S0012-3692(19)34214-X. doi: 10.1016/j.chest.2019.10.043. [Epub ahead of print]

PMID: 31738929 Free Article

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Select item 31734755

 

  1. Sports practice predicts better functional capacity in children and adults with Fontan circulation.

Rato J, Sousa A, Cordeiro S, Mendes M, Anjos R.

Int J Cardiol. 2019 Nov 16. pii: S0167-5273(19)33138-9. doi: 10.1016/j.ijcard.2019.11.116. [Epub ahead of print]

PMID: 31785955

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Select item 31732763

 

  1. Prevalence of selected cardiotropic pathogens in the myocardium of adult dogs with unexplained myocardial and rhythm disorders or with congenital heart disease.

Santilli RA, Grego E, Battaia S, Gianella P, Tursi M, Di Girolamo N, Biasato I, Perego M.

J Am Vet Med Assoc. 2019 Nov 15;255(10):1150-1160. doi: 10.2460/javma.255.10.1150.

PMID: 31687895

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Select item 31730717

 

  1. Cardiac Magnetic Resonance Derived Metrics are Predictive of Liver Fibrosis in Fontan Patients.

Trusty PM, Wei ZA, Rychik J, Graham A, Russo PA, Surrey LF, Goldberg DJ, Yoganathan AP, Fogel MA.

Ann Thorac Surg. 2019 Nov 14. pii: S0003-4975(19)31696-0. doi: 10.1016/j.athoracsur.2019.09.070. [Epub ahead of print]

PMID: 31734244

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Select item 31743221

 

  1. Management of People With a Fontan Circulation: a Cardiac Society of Australia and New Zealand Position statement.

Zentner D, Celermajer DS, Gentles T, d’Udekem Y, Ayer J, Blue GM, Bridgman C, Burchill L, Cheung M, Cordina R, Culnane E, Davis A, du Plessis K, Eagleson K, Finucane K, Frank B, Greenway S, Grigg L, Hardikar W, Hornung T, Hynson J, Iyengar AJ, James P, Justo R, Kalman J, Kasparian N, Le B, Marshall K, Mathew J, McGiffin D, McGuire M, Monagle P, Moore B, Neilsen J, O’Connor B, O’Donnell C, Pflaumer A, Rice K, Sholler G, Skinner JR, Sood S, Ward J, Weintraub R, Wilson T, Wilson W, Winlaw D, Wood A.

Heart Lung Circ. 2019 Nov 14. pii: S1443-9506(19)31458-1. doi: 10.1016/j.hlc.2019.09.010. [Epub ahead of print]

PMID: 31735685 Free Article

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Select item 31763440

 

  1. Perceived health competence predicts anxiety and depressive symptoms after a three-year follow-up among adolescents and adults with congenital heart disease.

Leslie CE, Schofield K, Vannatta K, Jackson JL.

Eur J Cardiovasc Nurs. 2019 Nov 13:1474515119885858. doi: 10.1177/1474515119885858. [Epub ahead of print]

PMID: 31722548

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Select item 31735919

 

  1. Prevalence, features and predictive factors of liver nodules in Fontan surgery patients: The VALDIG Fonliver prospective cohort.

Téllez L, Rodríguez de Santiago E, Minguez B, Payance A, Clemente A, Baiges A, Morales-Arraez D, La Mura V, Llop E, Garrido E, Garrido-Lestache E, Tasayco S, Bruno O, Prieto R, Montserrat S, Pons M, Olavarría A, Dos L, Valla D, Jesús Del Cerro M, Bañares R, García-Pagán JC, Rautou PE, Albillos A; VALDIG an EASL consortium.

J Hepatol. 2019 Nov 11. pii: S0168-8278(19)30668-3. doi: 10.1016/j.jhep.2019.10.027. [Epub ahead of print]

PMID: 31726116

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Select item 31711070

 

  1. Pitfalls of using IQ short forms in neurodevelopmental disorders: a study in patients with congenital heart disease.

Ehrler M, Latal B, Polentarutti S, von Rhein M, Held L, Wehrle FM.

Pediatr Res. 2019 Nov 11. doi: 10.1038/s41390-019-0667-2. [Epub ahead of print]

PMID: 31711070

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Select item 31712678

 

  1. Association between the 4p16 genomic locus and different types of congenital heart disease: results from adult survivors in the UK Biobank.

Córdova-Palomera A, Priest JR.

Sci Rep. 2019 Nov 11;9(1):16515. doi: 10.1038/s41598-019-52969-x.

PMID: 31712678 Free PMC Article

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Select item 31712631

 

  1. Surrogates for myocardial power and power efficiency in patients with aortic valve disease.

Lee CB, Goubergrits L, Fernandes JF, Nordmeyer S, Knosalla C, Berger F, Falk V, Kuehne T, Kelm M.

Sci Rep. 2019 Nov 11;9(1):16407. doi: 10.1038/s41598-019-52909-9.

PMID: 31712631 Free PMC Article

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Select item 31082074

 

  1. Controlling the cost of management of congenital heart disease (Reply).

McHugh KE, Pasquali SK, Mahle WT.

Ann Thorac Surg. 2019 Nov 7. pii: S0003-4975(19)31628-5. doi: 10.1016/j.athoracsur.2019.09.054. [Epub ahead of print] No abstract available.

PMID: 31706876

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Select item 31696653

 

  1. Neurodevelopmental outcomes of children with congenital heart disease: A review.

Howell HB, Zaccario M, Kazmi SH, Desai P, Sklamberg FE, Mally P.

Curr Probl Pediatr Adolesc Health Care. 2019 Nov 7:100685. doi: 10.1016/j.cppeds.2019.100685. [Epub ahead of print]

PMID: 31708366

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Select item 31788459

 

  1. Repair of Complex Transposition of Great Arteries: Up to 30 Years of Follow-Up.

Kari FA, Bohnens H, Bierbach B, Bacha EA, Stiller B, Bauer U.

Ann Thorac Surg. 2019 Nov 9. pii: S0003-4975(19)31682-0. doi: 10.1016/j.athoracsur.2019.09.059. [Epub ahead of print]

PMID: 31715151

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Select item 31705822

 

28 .Update on stem cell technologies in congenital heart disease.

Brown MA, Rajamarthandan S, Francis B, O’Leary-Kelly MK, Sinha P.

J Card Surg. 2019 Nov 9. doi: 10.1111/jocs.14312. [Epub ahead of print] Review.

PMID: 31705822

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Select item 31715418

 

  1. Repaired coarctation of the aorta, persistent arterial hypertension and the selfish brain.

Rodrigues JCL, Jaring MFR, Werndle MC, Mitrousi K, Lyen SM, Nightingale AK, Hamilton MCK, Curtis SL, Manghat NE, Paton JFR, Hart EC.

J Cardiovasc Magn Reson. 2019 Nov 7;21(1):68. doi: 10.1186/s12968-019-0578-8.

PMID: 31703697 Free PMC Article

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Select item 31701594

 

  1. Advanced Heart Failure Therapies for Adults With Congenital Heart Disease: JACC State-of-the-Art Review.

Givertz MM, DeFilippis EM, Landzberg MJ, Pinney SP, Woods RK, Valente AM.

J Am Coll Cardiol. 2019 Nov 5;74(18):2295-2312. doi: 10.1016/j.jacc.2019.09.004. Review.

PMID: 31672187

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Select item 31657270

 

  1. Metabolic Remodeling in the Pressure-Loaded Right Ventricle: Shifts in Glucose and Fatty Acid Metabolism-A Systematic Review and Meta-Analysis.

Koop AC, Bossers GPL, Ploegstra MJ, Hagdorn QAJ, Berger RMF, Silljé HHW, Bartelds B.

J Am Heart Assoc. 2019 Nov 5;8(21):e012086. doi: 10.1161/JAHA.119.012086. Epub 2019 Oct 28.

PMID: 31657265 Free Article

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Select item 31656122

 

  1. Predictors of Late Mortality in D-Transposition of the Great Arteries After Atrial Switch Repair: Systematic Review and Meta-Analysis.

Venkatesh P, Evans AT, Maw AM, Pashun RA, Patel A, Kim L, Feldman D, Minutello R, Wong SC, Stribling JC, LaPar D, Holzer R, Ginns J, Bacha E, Singh HS.

J Am Heart Assoc. 2019 Nov 5;8(21):e012932. doi: 10.1161/JAHA.119.012932. Epub 2019 Oct 23.

PMID: 31642369 Free Article

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Select item 31619105

 

  1. Longitudinal Analysis of Ventilation Perfusion Mismatch in Congenital Diaphragmatic Hernia Survivors.

Dao DT, Kamran A, Wilson JM, Sheils CA, Kharasch VS, Mullen MP, Rice-Townsend SE, Zalieckas JM, Morash D, Studley M, Staffa SJ, Zurakowski D, Becker RE, Smithers CJ, Buchmiller TL.

J Pediatr. 2019 Nov 5. pii: S0022-3476(19)31219-3. doi: 10.1016/j.jpeds.2019.09.053. [Epub ahead of print]

PMID: 31704054

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Select item 31688674

 

  1. Exercise testing for assessment of heart failure in adults with congenital heart disease.

Burstein DS, Menachem JN, Opotowsky AR.

Heart Fail Rev. 2019 Nov 4. doi: 10.1007/s10741-019-09867-1. [Epub ahead of print] Review.

PMID: 31686282

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Select item 31781201

 

  1. Pregnancy outcome in women with atrial septal defect: associated with in vitro fertilisation and pre-eclampsia.

Udholm S, Udholm L, Nyboe C, Kesmodel US, Hjortdal VE.

Open Heart. 2019 Nov 2;6(2):e001148. doi: 10.1136/openhrt-2019-001148. eCollection 2019.

PMID: 31798916 Free PMC Article

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Select item 31271655

 

  1. Standardized outcomes in reproductive cardiovascular care: The STORCC initiative.

Valente AM, Landzberg MJ, Gauvreau K, Egidy-Assenza G, Barker N, Partington S, Morgan RB, Harmon AJ, Hickey K, Mullen MP, Carabuena JM, O’Gara P, Economy KE; STORCC Investigators.

Am Heart J. 2019 Nov;217:112-120. doi: 10.1016/j.ahj.2019.07.015. Epub 2019 Aug 9.

PMID: 31520896

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Select item 31493728

 

  1. Relation of Magnetic Resonance Elastography to Fontan Failure and Portal Hypertension.

Alsaied T, Possner M, Lubert AM, Trout AT, Szugye C, Palermo JJ, Lorts A, Goldstein BH, Veldtman GR, Anwar N, Dillman JR.

Am J Cardiol. 2019 Nov 1;124(9):1454-1459. doi: 10.1016/j.amjcard.2019.07.052. Epub 2019 Aug 7.

PMID: 31474329

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Select item 31321831

 

  1. Mediating effects of exercise capacity on the association between physical activity and health-related quality of life among adolescents with complex congenital heart disease.

Kim HJ, Jae SY, Choo J, Yoon JK, Kim SH, Königstein K, Schmidt-Trucksäss A, Franklin BA.

Am J Hum Biol. 2019 Nov;31(6):e23297. doi: 10.1002/ajhb.23297. Epub 2019 Jul 18.

PMID: 31321831

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Select item 31064194

 

  1. Alcohol Consumption and Aortic Root Dilatation: Insights from the Corinthia Study.

Oikonomou E, Lazaros G, Tsalamandris S, Vogiatzi G, Christoforatou E, Papakonstantinou M, Goliopoulou A, Tousouli M, Chasikidis C, Tousoulis D.

Angiology. 2019 Nov;70(10):969-977. doi: 10.1177/0003319719848172. Epub 2019 May 7.

PMID: 31064194

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Select item 31400339

 

  1. Outcomes of Bioprosthetic Valves in the Pulmonary Position in Adults With Congenital Heart Disease.

Egbe AC, Connolly HM, Miranda WR, Dearani JA, Schaff HV.

Ann Thorac Surg. 2019 Nov;108(5):1410-1415. doi: 10.1016/j.athoracsur.2019.05.068. Epub 2019 Jul 16.

PMID: 31323213

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Select item 31299232

 

  1. Learning strategies among adult CHD fellows.

Bokma JP, Daily JA, Kovacs AH, Oechslin EN, Baumgartner H, Khairy P, Mulder BJM, Veldtman GR.

Cardiol Young. 2019 Nov;29(11):1356-1360. doi: 10.1017/S1047951119002063. Epub 2019 Sep 10.

PMID: 31502529

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Select item 31489832

 

  1. Opinions of general and adult congenital heart disease cardiologists on care for adults with congenital heart disease in Belgium: a qualitative study.

Willems R, de Hosson M, De Backer J, Annemans L.

Cardiol Young. 2019 Nov;29(11):1368-1374. doi: 10.1017/S1047951119002245. Epub 2019 Sep 6.

PMID: 31489832

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Select item 30983081

 

  1. High-Output Heart Failure From Growth of Vascular Malformations in Multiple Gestation Pregnancy.

Srivastava PK, Vyas N, Jones J, Wong TC, Holliman K, Small AJ, Rao RR, Dowling EP, Finn JP, Duckwiler GR, Reardon LC, Aboulhosn JA, Ascher SB, Hogeling M, Lluri G, Yang EH.

Circ Heart Fail. 2019 Nov;12(11):e006561. doi: 10.1161/CIRCHEARTFAILURE.119.006561. Epub 2019 Oct 29. No abstract available.

PMID: 31658832 Free Article

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Select item 31677063

 

  1. Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals.

Kayvanpour E, Sedaghat-Hamedani F, Gi WT, Tugrul OF, Amr A, Haas J, Zhu F, Ehlermann P, Uhlmann L, Katus HA, Meder B.

Clin Res Cardiol. 2019 Nov;108(11):1297-1308. doi: 10.1007/s00392-019-01465-3. Epub 2019 Apr 12.

PMID: 30980206

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Select item 31419027

 

  1. Hepatic pathology in patients after Fontan operation: A computed tomography imaging study.

Chen YC, Weng KP, Chien KJ, Chen BH, Hsieh KS, Tai IH, Huang SH, Peng HH, Huang JS, Wu MT.

Crit Care Med. 2019 Nov;82(11):856-860. doi: 10.1097/JCMA.0000000000000185.

PMID: 31693533

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Select item 31686645

 

  1. The strange case of congenital mitral stenosis in an adult man with cor triatriatum.

Burzo ML, De Matteis G, Nicolazzi MA, Fedele E, Della Polla DA, Pennestrì F, Favuzzi AMR.

Echocardiography. 2019 Nov;36(11):2122-2125. doi: 10.1111/echo.14497. Epub 2019 Oct 1.

PMID: 31573705

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Select item 30957859

 

  1. Heart failure risk predictions in adult patients with congenital heart disease: a systematic review.

Wang F, Harel-Sterling L, Cohen S, Liu A, Brophy JM, Paradis G, Marelli AJ.

Heart. 2019 Nov;105(21):1661-1669. doi: 10.1136/heartjnl-2019-314977. Epub 2019 Jul 26. Review.

PMID: 31350277

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Select item 31292191

 

  1. Outcome following heart transplant assessment in adults with congenital heart disease.

Crossland DS, Jansen K, Parry G, Harper A, Perri G, Davidson A, De Rita F, Hermuzi A, Nassar M, Seller N, MacGowan GA, Hasan A, O’Sullivan JJ, Coats L.

Heart. 2019 Nov;105(22):1741-1747. doi: 10.1136/heartjnl-2019-314711. Epub 2019 Jul 5.

PMID: 31278142 Free PMC Article

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Select item 31273028

 

  1. Cardiopulmonary exercise testing and sports participation in adults with congenital heart disease.

Buber J, Shafer K.

Heart. 2019 Nov;105(21):1670-1679. doi: 10.1136/heartjnl-2018-313928. Epub 2019 Jul 4. No abstract available.

PMID: 31273028

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Select item 31129614

 

  1. Maternal and fetal outcomes in pregnancies complicated by Marfan syndrome.

Cauldwell M, Steer PJ, Curtis SL, Mohan A, Dockree S, Mackillop L, Parry HM, Oliver J, Sterrenberg M, Wallace S, Malin G, Partridge G, Freeman LJ, Bolger AP, Siddiqui F, Wilson D, Simpson M, Walker N, Hodson K, Thomas K, Bredaki F, Mercaldi R, Walker F, Johnson MR.

Heart. 2019 Nov;105(22):1725-1731. doi: 10.1136/heartjnl-2019-314817. Epub 2019 May 25.

PMID: 31129614 Free Article

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Select item 31069588

 

  1. Left atrial enlargement as a maker of significant high-risk patent foramen ovale.

Rigatelli G, Zuin M, Adami A, Aggio S, Lanza D, d’Elia K, Braggion G, Russo M, Mazza A, Roncon L.

Int J Cardiovasc Imaging. 2019 Nov;35(11):2049-2056. doi: 10.1007/s10554-019-01666-x. Epub 2019 Jul 19.

PMID: 31325066

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Select item 31203534

 

  1. Ten-year experience of Q fever endocarditis in a tertiary cardiac center in Saudi Arabia.

Elzein FE, Alsherbeeni N, Alnajashi K, Alsufyani E, Akhtar MY, Albalawi R, Albarrag AM, Kaabia N, Mehdi S, Alzahrani A, Raoult D.

Int J Infect Dis. 2019 Nov;88:21-26. doi: 10.1016/j.ijid.2019.07.035. Epub 2019 Aug 2.

PMID: 31382048 Free Article

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Select item 31361302

 

  1. Diagnostic and prognostic significance of cardiovascular vortex formation.

Kheradvar A, Rickers C, Morisawa D, Kim M, Hong GR, Pedrizzetti G.

J Cardiol. 2019 Nov;74(5):403-411. doi: 10.1016/j.jjcc.2019.05.005. Epub 2019 Jun 26. Review.

PMID: 31255458

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Select item 31688514

 

  1. Healthcare transition for adolescents and young adults with long-term conditions: Qualitative study of patients, parents and healthcare professionals’ experiences.

Coyne I, Sheehan A, Heery E, While AE.

J Clin Nurs. 2019 Nov;28(21-22):4062-4076. doi: 10.1111/jocn.15006. Epub 2019 Aug 26.

PMID: 31327174

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Select item 31723395

 

  1. A rare case of adult congenital heart disease: single ventricular chamber with anomalous right coronary artery in an octogenarian.

Rawala MS, Ahmed AS, Rizvi SB.

J Community Hosp Intern Med Perspect. 2019 Nov 1;9(5):446-448. doi: 10.1080/20009666.2019.1655625. eCollection 2019.

PMID: 31723395 Free PMC Article

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Select item 31738213

 

  1. Palliative Care Opportunities Among Adults With Congenital Heart Disease-A Systematic Review.

Ludmir J, Steiner JM, Wong HN, Kloosterboer A, Leong J, Aslakson RA; AAHPM Research Committee Writing Group.

J Pain Symptom Manage. 2019 Nov;58(5):891-898. doi: 10.1016/j.jpainsymman.2019.07.025. Epub 2019 Aug 9.

PMID: 31404639

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Select item 31655705

 

  1. Palliative Care Opportunities Among Adults With Congenital Heart Disease-A Systematic Review.

Ludmir J, Steiner JM, Wong HN, Kloosterboer A, Leong J, Aslakson RA; AAHPM Research Committee Writing Group.

J Pain Symptom Manage. 2019 Nov;58(5):891-898. doi: 10.1016/j.jpainsymman.2019.07.025. Epub 2019 Aug 9.

PMID: 31404639

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Select item 31655705

 

  1. Bilateral lung transplantation after caesarean section in pregnancy with severe pulmonary arterial hypertension: A case report.

Ye J, Chen JY, Xu N, Wu B, Wang ZP, Xu HY, Ma JQ.

Medicine (Baltimore). 2019 Nov;98(47):e18109. doi: 10.1097/MD.0000000000018109.

PMID: 31764849 Free Article

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Select item 31702616

 

  1. Pulmonary Hypertension and Pregnancy.

Martin SR, Edwards A.

Obstet Gynecol. 2019 Nov;134(5):974-987. doi: 10.1097/AOG.0000000000003549.

PMID: 31599832

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Select item 31532867

 

  1. Klippel-Trenaunay syndrome as a rare cause of chronic thromboemboembolic pulmonary hypertension.

Seferian A, Jaïs X, Savale L, Jevnikar M, Ghigna MR, Weatherald J, Assoun S, Fadel E, Simonneau G, Sitbon O, Humbert M, Montani D.

Respir Med Res. 2019 Nov;76:48-53. doi: 10.1016/j.resmer.2019.06.002. Epub 2019 Jul 9.

PMID: 31557688

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Select item 31560988

 

  1. Pregnancy outcomes in mixed connective tissue disease: a multicentre study.

Radin M, Schreiber K, Cuadrado MJ, Cecchi I, Andreoli L, Franceschini F, Caleiro T, Andrade D, Gibbone E, Khamashta M, Buyon J, Izmirly P, Aguirre MA, Benedetto C, Roccatello D, Marozio L, Sciascia S.

Rheumatology (Oxford). 2019 Nov 1;58(11):2000-2008. doi: 10.1093/rheumatology/kez141.

PMID: 31079145

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Select item 31385648

 

  1. Left ventricular remodelling among Turner syndrome patients: insights from non-invasive 3D echocardiography-derived pressure-volume loop analysis.

Oberhoffer FS, Abdul-Khaliq H, Jung AM, Rohrer TR, Abd El Rahman M.

Clin Res Cardiol. 2019 Nov 30. doi: 10.1007/s00392-019-01579-8. [Epub ahead of print]

PMID: 31786629

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Select item 31735772

 

  1. Listen to the Heart – Rare Cardiac Tumor in an Adolescent.

Noessler N, Schweintzger S, Koestenberger M, Kurath-Koller S.

Klin Padiatr. 2019 Nov 26. doi: 10.1055/a-1047-0503. [Epub ahead of print] No abstract available.

PMID: 31770781

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Select item 31771606

 

  1. Heart failure biomarker levels correlate with invasive haemodynamics in pulmonary valve replacement.

Zegelbone PM, Ringel RE, Coulson JD, Nies MK, Stabler ME, Brown JR, Everett AD.

Cardiol Young. 2019 Nov 27:1-5. doi: 10.1017/S1047951119002737. [Epub ahead of print]

PMID: 31771681

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  1. Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure.

Spiekerkoetter E, Goncharova EA, Guignabert C, Stenmark K, Kwapiszewska G, Rabinovitch M, Voelkel N, Bogaard HJ, Graham B, Pullamsetti SS, Kuebler WM.

Pulm Circ. 2019 Nov 20;9(4):2045894019889775. doi: 10.1177/2045894019889775. eCollection 2019 Oct-Dec.

PMID: 31798835 Free PMC Article

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Select item 31739742

 

  1. Pathophysiologic and Prognostic Implications of Right Atrial Hypertension in Adults With Tetralogy of Fallot.

Egbe AC, Bonnichsen C, Reddy YNV, Anderson JH, Borlaug BA.

J Am Heart Assoc. 2019 Nov 19;8(22):e014148. doi: 10.1161/JAHA.119.014148. Epub 2019 Nov 8.

PMID: 31701796 Free Article

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Select item 31742886

 

  1. Exome sequencing identifies a FHOD3 p.S527del mutation in a Chinese family with hypertrophic cardiomyopathy.

Huang S, Pu T, Wei W, Xu R, Wu Y.

J Gene Med. 2019 Nov 19:e3146. doi: 10.1002/jgm.3146. [Epub ahead of print]

PMID: 31742804

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Select item 31742787

 

  1. Flow quantification dependency on background phase correction techniques in 4D-flow MRI.

Callaghan FM, Burkhardt B, Geiger J, Valsangiacomo Buechel ER, Kellenberger CJ.

Magn Reson Med. 2019 Nov 19. doi: 10.1002/mrm.28085. [Epub ahead of print]

PMID: 31742787

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Select item 31745583

 

  1. Providing a framework of principles for conceptualising the Fontan Circulation.

Gewillig M, Brown SC, van de Bruaene A, Rychik J.

Acta Paediatr. 2019 Nov 18. doi: 10.1111/apa.15098. [Epub ahead of print] Review.

PMID: 31737940

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Select item 31761401

 

  1. Outcome of the Glenn procedure as definitive palliation in single ventricle patients.

Vermaut A, De Meester P, Troost E, Roggen L, Goossens E, Moons P, Rega F, Meyns B, Gewillig M, Budts W, Van De Bruaene A.

Int J Cardiol. 2019 Nov 18. pii: S0167-5273(19)34712-6. doi: 10.1016/j.ijcard.2019.10.031. [Epub ahead of print]

PMID: 31761401

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Select item 31812566

 

  1. Retrosternal Clots After Fontan Surgery by Systematic Evaluation With Transthoracic Ultrasound.

Cantinotti M, Giordano R, Marchese P, Franchi E, Viacava C, Pak V, Murzi B, Arcieri L, Poli V, Federici D, Koestenberger M, Assanta N.

J Cardiothorac Vasc Anesth. 2019 Nov 18. pii: S1053-0770(19)31156-5. doi: 10.1053/j.jvca.2019.11.009. [Epub ahead of print]

PMID: 31812566

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Select item 31741130

 

  1. Results of the Fontan Udenafil Exercise Longitudinal (FUEL) Trial.

Goldberg DJ, Zak V, Goldstein BH, Schumacher KR, Rhodes J, Penny DJ, Petit CJ, Ginde S, Menon SC, Kim SH, Kim GB, Nowlen TT, DiMaria MV, Frischhertz BP, Wagner JB, McHugh KE, McCrindle BW, Shillingford AJ, Sabati AA, Yetman AT, John AS, Richmond ME, Files MD, Payne RM, Mackie AS, Davis CK, Shahanavaz S, Hill KD, Garg R, Jacobs JP, Hamstra MS, Woyciechowski S, Rathge KA, McBride MG, Frommelt PC, Russell MW, Urbina EM, Yeager JL, Pemberton VL, Stylianou MP, Pearson GD, Paridon SM; Pediatric Heart Network Investigators.

Circulation. 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044352. [Epub ahead of print]

PMID: 31736357

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Select item 31736331

 

  1. Sports practice predicts better functional capacity in children and adults with Fontan circulation.

Rato J, Sousa A, Cordeiro S, Mendes M, Anjos R.

Int J Cardiol. 2019 Nov 16. pii: S0167-5273(19)33138-9. doi: 10.1016/j.ijcard.2019.11.116. [Epub ahead of print]

PMID: 31785955

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Select item 31734750

 

  1. Giant pseudo-aneurysm of the right ventricular outflow tract after Tetralogy of Fallot repair.

Rato J, Ataíde R, Teixeira A.

Cardiol Young. 2019 Nov 15:1-3. doi: 10.1017/S1047951119002579. [Epub ahead of print]

PMID: 31729309

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Select item 30684297

 

  1. Impact of phrenic nerve palsy on late Fontan circulation.

Komori M, Hoashi T, Shimada M, Kitano M, Ohuchi H, Kurosaki K, Ichikawa H.

Ann Thorac Surg. 2019 Nov 13. pii: S0003-4975(19)31690-X. doi: 10.1016/j.athoracsur.2019.09.064. [Epub ahead of print]

PMID: 31733188

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Select item 31798515

 

  1. Ultrafast Ultrasound Imaging in Pediatric and Adult Cardiology: Techniques, Applications, and Perspectives.

Villemain O, Baranger J, Friedberg MK, Papadacci C, Dizeux A, Messas E, Tanter M, Pernot M, Mertens L.

JACC Cardiovasc Imaging. 2019 Nov 11. pii: S1936-878X(19)30943-X. doi: 10.1016/j.jcmg.2019.09.019. [Epub ahead of print] Review.

PMID: 31734211

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Select item 31629745

 

  1. Older patients with anomalous origin of the pulmonary artery from the ascending aorta: Guidance via lung biopsy.

Zhao J, Si MS, Wang X, Chen S, Yan Q, Chen J.

J Card Surg. 2019 Nov 6. doi: 10.1111/jocs.14322. [Epub ahead of print]

PMID: 31692091

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Select item 31694058

 

  1. The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation.

Koski TK, Suominen PK, Raissadati A, Knihtilä HM, Ojala TH, Salminen JT.

Acta Anaesthesiol Scand. 2019 Nov;63(10):1384-1389. doi: 10.1111/aas.13431. Epub 2019 Jul 16.

PMID: 31271655

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Select item 30799635

 

  1. Adult tetralogy repair: factors affecting early outcome in the current era.

Ramanan S, Sasikumar N, Manohar K, Ramani SS, Kumar RS, Agarwal R, Subramanyam R, Cherian KM.

Asian Cardiovasc Thorac Ann. 2019 Nov;27(9):731-737. doi: 10.1177/0218492319882870. Epub 2019 Oct 9. No abstract available.

PMID: 31594378

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Select item 31288550

 

  1. Late “failing” Fontan: 20-year experience of a tertiary centre in Portugal.

Correia-Costa A, Granja S.

Cardiol Young. 2019 Nov;29(11):1412-1413. doi: 10.1017/S104795111900221X. Epub 2019 Sep 24. No abstract available.

PMID: 31549603

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Select item 31522698

 

81.

 

 

ACHD Electrophysiology Featured Articles

Congenital and Pediatric Cardiac EP Review for  October-December 2019

 

Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease.

Yin Y, Dimopoulos K, Shimada E, Lascelles K, Griffiths S, Wong T, Gatzoulis MA, Babu-Narayan SV, Li W.

J Am Heart Assoc. 2019 Nov 5;8(21):e012744. doi: 10.1161/JAHA.119.012744. Epub 2019 Oct 28. Erratum in: J Am Heart Assoc. 2019 Dec 17;8(24):e014507.

PMID:  31657270

Free PMC Article

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 Take Home Points: 

  • Cardiac resynchronization therapy (CRT) appears to provide early and sustained late positive impact on measures related to heart failure in carefully selected patients with adult congenital heart disease (ACHD).
  • While findings similar to conventional CRT benefits in ischemic/non-ischemic cardiomyopathy can be achieved in ACHD patients with systemic morphologic LV’s, the same does not appear to be true in ACHD with systemic morphologic RV’s.

Comment from Dr. Philip Chang (Gainesville, FL), section editor of Congenital Electrophysiology Journal Watch:  This study by Yin et al retrospectively reviewed outcomes in ACHD patients referred for CRT at a single center between 2004-2017.  Factors considered in the application of CRT included reduced LVEF or RV fractional area change (FAC), NYHA functional class, QRS duration, and single-site ventricular pacing burden.  General demographic, cardiac, cardiac surgical, and clinical data; device implant-related variables; cardiothoracic ratio on x-ray, echo and surface ECG data; and follow-up assessment and outcomes variables were collected by chart review.  The authors defined bundle branch block as QRS duration ≥120 ms and positive CRT response as ≥5% increase in LVEF or RVFAC following CRT initiation.

A total of 54 patients with comprehensive data sets and follow-up duration were included for analysis.  Patient age varied widely (18-73 years, mean 46 years) and most patients were male (74%).  Mean follow-up duration from CRT was 5.7 years, with early and late follow-up arbitrarily delineated as mean 1.8±0.8 years and 4.7±0.8 years, respectively, after CRT device implant.  A majority of patients had systemic morphologic LV’s (39 patients, 72%) comprised of several forms of CHD while the remaining patients with systemic morphologic RV’s had either D- or L-TGA variants (the majority being L-TGA, 13/15 patients).  Of the entire cohort, 33/54 patients met a primary ventricular pacing indication prior to CRT, either due to high-grade AV block or following AV node ablation.  Over half of the cohort had preexisting cardiac implantable devices (21 pacemakers, 10 ICD’s).  In total, 46/54 patients were implanted with a CRT-D device with the remaining 8 patients implanted with CRT-P systems.  The vast majority of patients received transvenous systems only (52/54); 2 patients underwent hybrid transvenous and surgical epicardial lead placement.  19% of patients experienced complications including infection (5 patients, 9%) and lead dislodgement (3 patients, 6%).

Overall, a positive response to CRT was noted in 65% of the entire cohort.  This was primarily driven by favorable early and late responses in ACHD patients with systemic LV’s.  Figure 1 from the manuscript depicts the changes in CT ratio (B), QRS duration (C), NYHA class (D), systemic LVEF (E), and systemic RVFAC (F) over the time points of the analysis.  In general, while there was overall improvement across all measures of CRT response at early follow-up, only NYHA class improvement and LV functional measures were sustained at late follow-up.  Among systemic LV recipients, most (74%) had improvement in LVEF that was sustained out to nearly 2 years following CRT.  Systemic LV patients with history of LVOT obstructive CHD showed the highest response (15/17 patients, 88%).  Only 40% of systemic RV patients exhibited early-term positive response.  All-cause mortality occurred in 20% of patients during follow-up.  Multi-variate analysis showed QRS duration to be the only independent predictor of CRT response irrespective of permanent pacing or QRS morphology.  Kaplan Meier analysis shows somewhat contrary data with systemic RV patients actually exhibiting a longer duration of freedom from death or transplant compared to systemic LV patients following CRT.  No comparison to non-CRT cohorts was made.

Though there are substantial limitations to this study, it provides some data and insights into longer-term outcomes in ACHD patients receiving CRT, which is still insufficiently understood given low cohort sizes across multiple studies.  The rather high complication rate following CRT device implants reported in this study likely reflects the contributions of device-related re-interventions in patients with pre-existing cardiac implantable devices and other comorbidities, which are recognized to increase the risk of infections, as well as the technical challenges of CRT implant in CHD, even among patients with systemic LV’s.  From studies and trials on CRT in ischemic and non-ischemic cardiomyopathy in baseline structurally normal hearts, positive CRT response is linked to LBBB-type wide QRS, wider QRS duration (paced or non-paced), and defined evidence of LV dyssynchrony.  Favorable response to CRT can generally be expected when application of biventricular or even multi-site ventricular pacing in these scenarios effectively targets the area of latest electrical activation.  Positive CRT response has also been associated with “ideal” target vessel lead implantation (usually lateral/free wall LV in a basilar/mid-LV location) as well as very high percentage biventricular pacing (>98%).  This study failed to mention consistent achievement of these variables, which certainly could affect CRT response.  With that said, the findings from this study are consistent with the notion that systemic LV ACHD appears to exhibit a similar response to CRT compared to conventional ischemic and nonischemic cardiomyopathy substrates with similar heart failure indices and variables.  The lower CRT response in systemic RV’s may reflect implant variables and lead placement along with the unique morphologic, structural, contractile, and electrophysiologic (i.e.. single RBB vs. left anterior and posterior fascicles in LBB) differences between RV’s and LV’s.  Ventricular inter-dependence was not mentioned in this study, which could potentially be of impact in patients where the subpulmonary ventricle also exhibits significant dysfunction (as in the case of tetralogy of Fallot patients with biventricular dysfunction).  Wider baseline QRS as an independent predictor of positive CRT response can likely be understood by viewing wider QRS duration as reflecting greater ventricular electrical delay and dyssynchrony, which should stand to improve if the region of greatest delay is properly resynchronized.  As the authors mentioned, there remains a lack of solid, consensus guidelines regarding patient selection and consistent clinical variables to guide CRT implant among the heterogeneous ACHD population.

 

CHD EP Nov 2019

  1. Implantable Cardioverter-Defibrillators and Patient-Reported Outcomes in Adults with Congenital Heart Disease: an International Study.

Lévesque V, Laplante L, Shohoudi A, Apers S, Kovacs AH, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Brouillette J, Casteigt B, Moons P, Khairy P; APPROACH-IS consortium and the International Society for Adult Congenital Heart Disease (ISACHD).

Heart Rhythm. 2019 Nov 29. pii: S1547-5271(19)31089-6. doi: 10.1016/j.hrthm.2019.11.026. [Epub ahead of print]

PMID: 31790832

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  1. Unexplained recurrent syncopes in a young noncompetitive runner.

Rigatelli G, Zuin M, Roncon L.

J Cardiovasc Med (Hagerstown). 2019 Nov 26. doi: 10.2459/JCM.0000000000000897. [Epub ahead of print]

PMID: 31789712

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Select item 31769098

 

  1. Insights from examination of hearts from adults dying suddenly to the understanding of congenital cardiac malformations.

Westaby JD, Cooper STE, Edwards KA, Anderson RH, Sheppard MN.

Clin Anat. 2019 Nov 25. doi: 10.1002/ca.23531. [Epub ahead of print]

PMID: 31769098

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Select item 31767648

 

  1. Cardiac resynchronization and implantable defibrillators in adults with congenital heart disease.

Chubb H, Motonaga KS.

Heart Fail Rev. 2019 Nov 21. doi: 10.1007/s10741-019-09886-y. [Epub ahead of print] Review.

PMID: 31754907

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Select item 31785958

 

  1. Placement of Reveal LINQ Device in the Left Anterior Axillary Position.

Anderson H, Dearani J, Qureshi MY, Holst K, O’Leary P, Cannon B, Wackel P.

Pediatr Cardiol. 2019 Nov 19. doi: 10.1007/s00246-019-02242-9. [Epub ahead of print]

PMID: 31745583

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Select item 31743362

 

  1. CMR feature tracking left ventricular strain-rate predicts ventricular tachyarrhythmia, but not deterioration of ventricular function in patients with repaired tetralogy of Fallot.

Hagdorn QAJ, Vos JDL, Beurskens NEG, Gorter TM, Meyer SL, van Melle JP, Berger RMF, Willems TP.

Int J Cardiol. 2019 Nov 15;295:1-6. doi: 10.1016/j.ijcard.2019.07.097. Epub 2019 Aug 1.

PMID: 31402156 Free Article

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Select item 31731673

 

  1. Comparison of the Stanford ECG Left Atrial Criteria With the International ECG Criteria for Sports Screening.

Hock J, Wheeler M, Singh T, Ha LD, Hadley D, Froelicher V.

Clin J Sport Med. 2019 Nov 14. doi: 10.1097/JSM.0000000000000766. [Epub ahead of print]

PMID: 31743221

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Select item 31735685

 

  1. Effect of right ventricular pacing on left ventricular systolic function in patients with Tetralogy of Fallot.

Egbe AC, Najam M, Banala K, Vojjini R, Osman K, Abhishek D.

Int J Cardiol Heart Vasc. 2019 Nov 14;26:100426. doi: 10.1016/j.ijcha.2019.100426. eCollection 2020 Feb.

PMID: 31763440 Free PMC Article

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Select item 31728571

 

  1. Atrial arrhythmia triggering electromechanical dissociation and ventricular fibrillation in a patient with atrial switch operation.

Combes N, Bartoletti S, Hascoët S, Vahdat O, Heitz F, Waldmann V.

Europace. 2019 Nov 12. pii: euz310. doi: 10.1093/europace/euz310. [Epub ahead of print] No abstract available.

PMID: 31713633

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Select item 31735417

 

  1. Outcomes during and after the use of the wearable cardioverter-defibrillator in a tertiary-care and a regional hospital in Switzerland.

Kovacs B, Reek S, Saguner AM, Krasniqi N, Eriksson U, Duru F.

Swiss Med Wkly. 2019 Nov 10;149:w20136. doi: 10.4414/smw.2019.20136. eCollection 2019 Nov 4.

PMID: 31707723 Free Article

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Select item 31715151

 

  1. Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease.

Yin Y, Dimopoulos K, Shimada E, Lascelles K, Griffiths S, Wong T, Gatzoulis MA, Babu-Narayan SV, Li W.

J Am Heart Assoc. 2019 Nov 5;8(21):e012744. doi: 10.1161/JAHA.119.012744. Epub 2019 Oct 28. Erratum in: J Am Heart Assoc. 2019 Dec 17;8(24):e014507.

PMID: 31657270 Free Article

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Select item 31657265

 

  1. Prevalence and Outcomes of Pediatric In-Hospital Cardiac Arrest Associated With Pulmonary Hypertension.

Morgan RW, Topjian AA, Wang Y, Atkin NJ, Kilbaugh TJ, McGowan FX, Berg RA, Mercer-Rosa L, Sutton RM, Himebauch AS.

Pediatr Crit Care Med. 2019 Nov 5. doi: 10.1097/PCC.0000000000002187. [Epub ahead of print]

PMID: 31688674

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Select item 31687920

 

  1. Extremely short setting of optimal sensed atrioventricular interval in patients after Fontan procedure with implanted dual-chamber pacemaker.

Miyazaki A, Yoshimura SI, Matsutani H, Miyake M, Negishi J, Yamanaka K, Yamada O, Doi H, Ohuchi H.

Cardiol Young. 2019 Nov;29(11):1375-1379. doi: 10.1017/S1047951119002257. Epub 2019 Sep 11.

PMID: 31507257

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Select item 31502529

 

  1. Catheter Ablation in Pediatric Congenital Heart Disease: A Modern Perspective.

Silva JNA, Van Hare GF.

Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e008019. doi: 10.1161/CIRCEP.119.008019. Epub 2019 Nov 14. No abstract available.

PMID: 31722542

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Select item 31722541

 

  1. Arrhythmia Mechanisms and Outcomes of Ablation in Pediatric Patients With Congenital Heart Disease.

Houck CA, Chandler SF, Bogers AJJC, Triedman JK, Walsh EP, de Groot NMS, Abrams DJ.

Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007663. doi: 10.1161/CIRCEP.119.007663. Epub 2019 Nov 14.

PMID: 31722541

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  1. Renal denervation for treating congenital long QT syndrome: shortening the QT interval or modulating sympathetic tone?

Kiuchi MG, Chen S, Carnagarin R, Matthews VB, Schlaich MP.

Europace. 2019 Nov 1;21(11):1755-1756. doi: 10.1093/europace/euz251. No abstract available.

PMID: 31603504

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Select item 31424500

 

  1. Aetiologies and temporal trends of atrioventricular block in young patients: a 20-year nationwide study.

Rudbeck-Resdal J, Christiansen MK, Johansen JB, Nielsen JC, Bundgaard H, Jensen HK.

Europace. 2019 Nov 1;21(11):1710-1716. doi: 10.1093/europace/euz206.

PMID: 31424500 Free PMC Article

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  1. Radiofrequency ablation of the cavotricuspid isthmus for management of atrial flutter in patients with congenital heart disease after tricuspid valve surgery: A single-center experience.

Kella DK, Yasin OZ, Isath AM, McLeod CJ, Canon B, Asirvatham SJ, Wackel PL.

Heart Rhythm. 2019 Nov;16(11):1621-1628. doi: 10.1016/j.hrthm.2019.04.045. Epub 2019 Apr 29.

PMID: 31048063

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Select item 31325066

 

  1. Sudden Cardiac Arrest in Adults With Congenital Heart Disease.

Waldmann V, Ladouceur M, Bougouin W, Combes N, Maltret A, Dumas F, Iserin L, Cariou A, Marijon E, Jouven X.

JACC Clin Electrophysiol. 2019 Nov;5(11):1355-1356. doi: 10.1016/j.jacep.2019.07.017. No abstract available.

PMID: 31753444

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Select item 31770213

 

  1. Ivabradine as an Adjunct for Refractory Junctional Ectopic Tachycardia Following Pediatric Cardiac Surgery: A Preliminary Study.

Kumar V, Kumar G, Tiwari N, Joshi S, Sharma V, Ramamurthy R.

World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):709-714. doi: 10.1177/2150135119876600.

PMID: 31701840

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Select item 31701839

 

  1. Predictors of Early Postoperative Supraventricular Tachyarrhythmias in Children After the Fontan Procedure.

Yasuhara J, Kuno T, Taki M, Toda K, Kumamoto T, Kojima T, Shimizu H, Yoshiba S, Kobayashi T, Sumitomo N.

Int Heart J. 2019 Nov 30;60(6):1358-1365. doi: 10.1536/ihj.19-099. Epub 2019 Nov 15.

PMID: 31735772 Free Article

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Select item 31786619

 

  1. QTc Prolongation and Risk of Torsades de Pointes in Hospitalized Pediatric Oncology Patients.

Lim TR, Rangaswami AA, Dubin AM, Kapphahn KI, Sakarovitch C, Long J, Motonaga KS, Trela T, Ceresnak SR.

J Pediatr. 2019 Nov 21. pii: S0022-3476(19)31341-1. doi: 10.1016/j.jpeds.2019.10.018. [Epub ahead of print]

PMID: 31761428

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  1. [Clinical and prognostic analysis of accessory pathway-induced dilated cardiomyopathy after catheter ablation in children].

Zhang Y, Li XM, Jiang H, Ge HY, Liu HJ, Li MT.

Zhonghua Xin Xue Guan Bing Za Zhi. 2019 Nov 24;47(11):901-906. doi: 10.3760/cma.j.issn.0253-3758.2019.11.009. Chinese.

PMID: 31744280

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  1. Clinical Profile and Long-Term Follow-Up of Children with Brugada Syndrome.

El-Battrawy I, Roterberg G, Schlentrich K, Liebe V, Lang S, Rudic B, Tülümen E, Zhou X, Borggrefe M, Akin I.

Pediatr Cardiol. 2019 Nov 20. doi: 10.1007/s00246-019-02254-5. [Epub ahead of print]

PMID: 31748893

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  1. Arrhythmogenic right ventricular cardiomyopathy presenting as myocarditis in young patients: a concealed relationship.

Rato J, Ataíde R, Martins D, Moldovan O, Cavaco D, Anjos R.

Rev Esp Cardiol (Engl Ed). 2019 Nov 18. pii: S1885-5857(19)30334-2. doi: 10.1016/j.rec.2019.10.007. [Epub ahead of print] English, Spanish. No abstract available.

PMID: 31753771

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Select item 31736357

 

  1. Tricuspid regurgitation complicating SAPIEN 3 valve implantation in pulmonary position.

Butera G, Hansen JH, Jones MI.

Catheter Cardiovasc Interv. 2019 Nov 15;94(6):894. doi: 10.1002/ccd.28083. Epub 2019 Jan 25. No abstract available.

PMID: 30684297

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Select item 31731876

 

  1. CMR feature tracking left ventricular strain-rate predicts ventricular tachyarrhythmia, but not deterioration of ventricular function in patients with repaired tetralogy of Fallot.

Hagdorn QAJ, Vos JDL, Beurskens NEG, Gorter TM, Meyer SL, van Melle JP, Berger RMF, Willems TP.

Int J Cardiol. 2019 Nov 15;295:1-6. doi: 10.1016/j.ijcard.2019.07.097. Epub 2019 Aug 1.

PMID: 31402156 Free Article

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Select item 31756661

 

  1. Multivariate analysis of TU wave complex on electrocardiogram in Andersen-Tawil syndrome with KCNJ2 mutations.

Horigome H, Ishikawa Y, Kokubun N, Yoshinaga M, Sumitomo N, Lin L, Kato Y, Tanabe-Kameda Y, Ohno S, Nagashima M, Horie M.

Ann Noninvasive Electrocardiol. 2019 Nov 14:e12721. doi: 10.1111/anec.12721. [Epub ahead of print]

PMID: 31724784

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Select item 31743221

 

  1. Electrophysiological features and radiofrequency catheter ablation of accessory pathways associated with atrioventricular discordance.

Takeuchi D, Toyohara K, Shoda M, Hagiwara N.

J Cardiovasc Electrophysiol. 2019 Nov 14. doi: 10.1111/jce.14273. [Epub ahead of print]

PMID: 31724792

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Select item 31735418

 

  1. The Progress and Significance of QRS Duration by Electrocardiography in Hypoplastic Left Heart Syndrome.

Karikari Y, Abdulkarim M, Li Y, Loomba RS, Zimmerman F, Husayni T.

Pediatr Cardiol. 2019 Nov 13. doi: 10.1007/s00246-019-02237-6. [Epub ahead of print]

PMID: 31722042

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Select item 31720744

 

  1. Atrial arrhythmia triggering electromechanical dissociation and ventricular fibrillation in a patient with atrial switch operation.

Combes N, Bartoletti S, Hascoët S, Vahdat O, Heitz F, Waldmann V.

Europace. 2019 Nov 12. pii: euz310. doi: 10.1093/europace/euz310. [Epub ahead of print] No abstract available.

PMID: 31713633

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Select item 31732132

 

  1. Percutaneous epicardial placement of a prototype miniature pacemaker under direct visualization: An infant porcine chronic survival study.

Kumthekar RN, Opfermann JD, Mass P, Clark BC, Moak JP, Sherwin ED, Whitman T, Marshall M, Berul CI.

Pacing Clin Electrophysiol. 2019 Nov 12. doi: 10.1111/pace.13843. [Epub ahead of print]

PMID: 31721231

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Select item 31720784

 

34.Catheter ablation of ventricular tachycardia in the pediatric patients: A single-center experience.

Wu J, Chen Y, Ji W, Gu B, Shen J, Fu L, Li F.

Pacing Clin Electrophysiol. 2019 Nov 7. doi: 10.1111/pace.13835. [Epub ahead of print]

PMID: 31701534

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Select item 31701166

 

  1. Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease.

Yin Y, Dimopoulos K, Shimada E, Lascelles K, Griffiths S, Wong T, Gatzoulis MA, Babu-Narayan SV, Li W.

J Am Heart Assoc. 2019 Nov 5;8(21):e012744. doi: 10.1161/JAHA.119.012744. Epub 2019 Oct 28. Erratum in: J Am Heart Assoc. 2019 Dec 17;8(24):e014507.

PMID: 31657270 Free Article

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  1. Successful right anteroseptal manifest accessory pathway cryoablation in a six-month infant with dyssynchrony-induced dilated cardiomyopathy.

Köşger P, Sevinç Şengül F, Kafalı HC, Uçar B, Ergül Y.

Anatol J Cardiol. 2019 Nov;22(5):272-275. doi: 10.14744/AnatolJCardiol.2019.93707. No abstract available.

PMID: 31674939 Free Article

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Select item 31199031

 

  1. High burden of premature ventricular contractions in structurally normal hearts: To worry or not in pediatric patients?

Sharma N, Cortez D, Imundo JR.

Ann Noninvasive Electrocardiol. 2019 Nov;24(6):e12663. doi: 10.1111/anec.12663. Epub 2019 Jun 14.

PMID: 31199031

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  1. Extremely short setting of optimal sensed atrioventricular interval in patients after Fontan procedure with implanted dual-chamber pacemaker.

Miyazaki A, Yoshimura SI, Matsutani H, Miyake M, Negishi J, Yamanaka K, Yamada O, Doi H, Ohuchi H.

Cardiol Young. 2019 Nov;29(11):1375-1379. doi: 10.1017/S1047951119002257. Epub 2019 Sep 11.

PMID: 31507257

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Select item 31502531

 

39, Catheter Ablation in Pediatric Congenital Heart Disease: A Modern Perspective.

Silva JNA, Van Hare GF.

Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e008019. doi: 10.1161/CIRCEP.119.008019. Epub 2019 Nov 14. No abstract available.

PMID: 31722542

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Select item 31722541

 

  1. Arrhythmia Mechanisms and Outcomes of Ablation in Pediatric Patients With Congenital Heart Disease.

Houck CA, Chandler SF, Bogers AJJC, Triedman JK, Walsh EP, de Groot NMS, Abrams DJ.

Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007663. doi: 10.1161/CIRCEP.119.007663. Epub 2019 Nov 14.

PMID: 31722541

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Select item 31638832

 

  1. Type 8 long QT syndrome: pathogenic variants in CACNA1C-encoded Cav1.2 cluster in STAC protein binding site.

Mellor GJ, Panwar P, Lee AK, Steinberg C, Hathaway JA, Bartels K, Christian S, Balaji S, Roberts JD, Simpson CS, Boczek NJ, Tester DJ, Radbill AE, Mok NS, Hamilton RM, Kaufman ES, Eugenio PL, Weiss R, January C, McDaniel GM, Leather RA, Erickson C, Falik S, Behr ER, Wilde AAM, Sanatani S, Ackerman MJ, Van Petegem F, Krahn AD, Laksman Z.

Europace. 2019 Nov 1;21(11):1725-1732. doi: 10.1093/europace/euz215.

PMID: 31408100

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  1. Challenging arrhythmias in a Wolff-Parkinson-White patient: Different physiology and adjacent troubles.

Ali H, Foresti S, Mariucci E, Bronzetti G, De Ambroggi G, Cappato R.

J Cardiovasc Electrophysiol. 2019 Nov;30(11):2542-2545. doi: 10.1111/jce.14173. Epub 2019 Sep 25. No abstract available.

PMID: 31515886

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Select item 31432598

 

  1. Automated external defibrillator use in a previously healthy 31-day-old infant with out-of-hospital cardiac arrest due to ventricular fibrillation.

Hoyt WJ Jr, Fish FA, Kannankeril PJ.

J Cardiovasc Electrophysiol. 2019 Nov;30(11):2599-2602. doi: 10.1111/jce.14125. Epub 2019 Aug 23.

PMID: 31432598

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  1. Ivabradine as an Adjunct for Refractory Junctional Ectopic Tachycardia Following Pediatric Cardiac Surgery: A Preliminary Study.

Kumar V, Kumar G, Tiwari N, Joshi S, Sharma V, Ramamurthy R.

World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):709-714. doi: 10.1177/2150135119876600.

PMID: 31701840

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ACHD Interventional Cardiology Featured Articles

Interventional Cardiology Reviews of October- December  2019 Manuscripts

Pulmonary hemorrhage in children with Alagille syndrome undergoing cardiac catheterization.

Adamson GT, Peng LF, Feinstein JA, Yarlagadda VV, Lin A, Wise-Faberowski L, McElhinney DB.

Catheter Cardiovasc Interv. 2019 Oct 4. doi: 10.1002/ccd.28508. [Epub ahead of print]

PMID: 31584246

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Take Home Points:

  • Patients with Alagille syndrome have a significant risk of pulmonary hemorrhage with both diagnostic and interventional cardiac catheterizations.
  • A diagnosis of tetralogy of Fallot, higher RV to aorta pressure ratio, and PA angioplasty are associated with an increased risk of pulmonary hemorrhage.
  • The exact etiology of this increased risk remains unknown and warrants further investigation.

Commentary from Dr. Ryan Romans (Kansas City, MO), section editor of Congenital Heart Disease Interventions Journal Watch:  Children with Alagille syndrome often have hemorrhagic complications during invasive procedures and are also at risk for spontaneous bleeds (particularly intracranial hemorrhage). This is thought to be a result of abnormalities in angiogenesis, hemostasis, and/or platelet function.  Some have suggested that the bleeding risk is associated with the severity of congenital cardiovascular phenotype. This bleeding risk contributes significantly to morbidity and mortality in this patient population. The large majority (90%) of children with Alagille syndrome have congenital heart disease. This typically affects the branch pulmonary arteries (PA), though the disease severity is highly variable. It can range from mild branch PA stenosis to severe diffuse PA hypoplasia. Tetralogy of Fallot (TOF) is seen in ~ 15% of children [including TOF with pulmonary atresia and major aortopulmonary collateral arteries (TOF/PA/MAPCAs)].  Patients with Alagille syndrome who have the most severe cardiovascular disease are frequently referred to the cardiac catheterization lab for diagnostic catheterizations to assist in surgical planning or for interventional procedures (pulmonary angioplasty and/or stent implantation).  Pulmonary hemorrhage is a known complication of branch PA intervention in general and has anecdotally been seen in higher frequencies in patients with Alagille syndrome.

Adamson et al report on their retrospective single center experience with 30 patients with Alagille syndrome who underwent a total of 87 cardiac catheterizations (median 2 per patient) over an 8 year period (2010-2018). The most common diagnosis was isolated branch PA stenosis/hypoplasia in 15 patients (50%) followed by TOF/PA/MAPCAs in 10 patients (33%), TOF in 4 patients (13%), and pulmonary atresia with an intact ventricular septum (PA/IVS) and MAPCAs in a single patient. Surgical intervention had been performed prior to the cardiac catheterization in 61% of cases. The cardiac catheterizations included branch PA interventions in 37% of the cases and were diagnostic cardiac catheterizations in the remaining 73%. All patients were systemically heparinized with an activated coagulation time maintained above 200 seconds.

Pulmonary hemorrhage occurred in 26/87 cardiac catheterizations (30%) and in 14/30 patients (46%). The majority of these (n=17, 65%) were mild hemorrhage (defined as mechanical ventilation <24 hours, no treatment other than a single packed red blood cell transfusion). There were 4 (15%) moderate hemorrhages (24-72 hours mechanical ventilation or >72 hours noninvasive positive pressure ventilation), and 5 (19%) severe hemorrhages (>72 hours mechanical ventilation, use of inotropic support, ECMO, or death). Only two of the hemorrhages were clearly due to a vessel tear from an intervention, though the source of bleeding was not always able to be identified on review of the medical records. Two hemorrhages were managed with venoarterial ECMO support without any major ECMO complications or deaths.  No patients required intravascular closure devices or covered stents to treat the hemorrhage.  All 9 moderate and severe hemorrhages occurred in 5 patients with TOF, three of whom had TOF/PA/MAPCAs.

The authors highlight that pulmonary hemorrhage occurred in approximately one third of procedures, including 44% of interventional and 22% of diagnostic cardiac catheterizations (incidence in patients without Alagille syndrome undergoing PA angioplasty 12-14% in two recent studies).  Fortunately, the majority of these were mild.  Two patient’s required ECMO support but there were no deaths.  Higher RV to aorta pressure ratio, intervention on the branch PAs, and a diagnosis of TOF were associated with pulmonary hemorrhage, with severe hemorrhage occurring primarily in patients with TOF/PA/MAPCAs. The authors note that the patient population they care for is not representative of a typical center’s given their expertise in surgical branch pulmonary arterioplasty (~12% of patients with Alagille syndrome have TOF with 1/3 of those TOF/PA/MAPCAs, nearly 50% with TOF and 2/3 of these with TOF/PA/MAPCAs in this cohort). Additionally, they may be less aggressive intervening in the cath lab given their centers preference for surgical intervention when possible and thus may be underestimating the risk of pulmonary hemorrhage.

 

CHD Interventions Nov 2019

 

  1. Interventional closure of patent foramen ovale in prevention of thromboembolic events. Consensus document of the Association of Cardiovascular Interventions and the Section of Grown‑up Congenital Heart Disease of the Polish Cardiac Society.

Araszkiewicz A, Bartuś S, Demkow M, Grygier M, Huczek Z, Komar M, Pracoń R, Przewłocki T, Sabiniewicz R, Smolka G, Olszowska M, Wojakowski W.

Kardiol Pol. 2019 Nov 22;77(11):1094-1105. doi: 10.33963/KP.15058. Epub 2019 Nov 13.

PMID: 31723115 Free Article

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  1. Percutaneous intraluminal downsizing of systemic-to-pulmonary artery shunts: a novel application of the Diabolo stent technique-Case series and description of the technique.

Maschietto N, Baird C, Porras D.

Catheter Cardiovasc Interv. 2019 Nov 19. doi: 10.1002/ccd.28598. [Epub ahead of print]

PMID: 31743550

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  1. Risk Factors and Predictors of Cardiac Erosion Discovered from 12 Japanese Patients Who Developed Erosion After Atrial Septal Defect Closure Using Amplatzer Septal Occluder.

Kitano M, Yazaki S, Sugiyama H, Ohtsuki SI, Tomita H.

Pediatr Cardiol. 2019 Nov 16. doi: 10.1007/s00246-019-02256-3. [Epub ahead of print]

PMID: 31732763

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  1. Percutaneous paraspinal access to the azygos vein to create a neo-vena cava.

Sorensen MW, Bauser-Heaton H, Petit CJ.

Catheter Cardiovasc Interv. 2019 Nov 15. doi: 10.1002/ccd.28597. [Epub ahead of print]

PMID: 31729148

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  1. Initial experiences with a novel biodegradable device for percutaneous closure of atrial septal defects: From preclinical study to first-in-human experience.

Li YF, Xie YM, Chen J, Li BN, Xie ZF, Wang SS, Zhang ZW.

Catheter Cardiovasc Interv. 2019 Nov 12. doi: 10.1002/ccd.28529. [Epub ahead of print]

PMID: 31714687

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  1. Antegrade transcatheter closure of a dehiscence of pulmonary bioprosthesis after pulmonary valve replacement with the Occlutech paravalvular leak device.

Godart F, Baudelet JB, Soquet J, Onorato E.

Catheter Cardiovasc Interv. 2019 Nov 12. doi: 10.1002/ccd.28587. [Epub ahead of print]

PMID: 31713974

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  1. Systemic Sirolimus to Prevent In-Stent Stenosis in Pediatric Pulmonary Vein Stenosis.

Callahan R, Esch JJ, Wang G, Ireland CM, Gauvreau K, Jenkins KJ.

Pediatr Cardiol. 2019 Nov 12. doi: 10.1007/s00246-019-02253-6. [Epub ahead of print]

PMID: 31720783

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  1. Invasive Cardiac Procedures in Interstage Single Ventricle Patients in Emergent Hospitalizations.

Haughey BS, White SC, Pacheco GS, Fox KA, Seckeler MD.

Pediatr Cardiol. 2019 Nov 8. doi: 10.1007/s00246-019-02247-4. [Epub ahead of print]

PMID: 31705178

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  1. Hybrid transcatheter pulmonary valve replacement with a SAPIEN S3 valve after pulmonary artery banding via left lateral thoracotomy.

Serfas JD, Turek J, Haney J, Krasuski RA, Fleming GA.

Catheter Cardiovasc Interv. 2019 Nov 7. doi: 10.1002/ccd.28591. [Epub ahead of print]

PMID: 31696653

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  1. Transcatheter Electrosurgery Rescue: Jailed Pulmonary Artery Following Melody Pulmonary Valve Replacement.

Nageotte SJ, Lee JW, El-Said HG, Moore JW, Ratnayaka K.

JACC Cardiovasc Interv. 2019 Nov 7. pii: S1936-8798(19)31886-2. doi: 10.1016/j.jcin.2019.08.051. [Epub ahead of print] No abstract available.

PMID: 31734303

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  1. Concomitant pulmonary vein isolation and percutaneous closure of atrial septal defects: A pilot project.

Evertz R, Houck CA, Ten Cate T, Duijnhouwer AL, Beukema R, Westra S, Vernooy K, de Groot NMS.

Congenit Heart Dis. 2019 Nov 6. doi: 10.1111/chd.12859. [Epub ahead of print]

PMID: 31692272

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  1. Transcatheter closure of right pulmonary artery to left atrium fistula in an infant: technical consideration and possible closure techniques.

Arya V, Azad S, Radhakrishnan S.

Cardiol Young. 2019 Nov 4:1-4. doi: 10.1017/S1047951119002592. [Epub ahead of print]

PMID: 31679544

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  1. Hybrid approach to ventricular septal defect enlargement.

Patel ND, Justino H, Ing FF.

Catheter Cardiovasc Interv. 2019 Nov 1;94(5):732-737. doi: 10.1002/ccd.28227. Epub 2019 Apr 14.

PMID: 30983081

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  1. Transcatheter closure of atrial septal defect in adults: time-course of atrial and ventricular remodeling and effects on exercise capacity.

Stephensen SS, Ostenfeld E, Kutty S, Steding-Ehrenborg K, Arheden H, Thilén U, Carlsson M.

Int J Cardiovasc Imaging. 2019 Nov;35(11):2077-2084. doi: 10.1007/s10554-019-01647-0. Epub 2019 Jun 15.

PMID: 31203534 Free PMC Article

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  1. Comprehensive literature review of anomalies of the coronary arteries.

Harky A, Noshirwani A, Karadakhy O, Ang J.

J Card Surg. 2019 Nov;34(11):1328-1343. doi: 10.1111/jocs.14228. Epub 2019 Aug 26. Review.

PMID: 31449703

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  1. Resolution of Protein-Losing Enteropathy after Congenital Heart Disease Repair by Selective Lymphatic Embolization.

Kylat RI, Witte MH, Barber BJ, Dori Y, Ghishan FK.

Pediatr Gastroenterol Hepatol Nutr. 2019 Nov;22(6):594-600. doi: 10.5223/pghn.2019.22.6.594. Epub 2019 Nov 7.

PMID: 31777727 Free PMC Article

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  1. Stroke After Cardiac Catheterization in Children.

Harrar DB, Salussolia CL, Vittner P, Danehy A, Sen S, Whitehill R, Chao JH, Bernson-Leung ME, Rivkin MJ.

Pediatr Neurol. 2019 Nov;100:42-48. doi: 10.1016/j.pediatrneurol.2019.07.005. Epub 2019 Jul 19.

PMID: 31481331

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  1. Long-term outcome of percutaneous intervention for pulmonary vein stenosis after pulmonary vein isolation procedure.

Suntharos P, Worley SE, Liu W, Siperstein M, Prieto LR.

Catheter Cardiovasc Interv. 2019 Nov 28. doi: 10.1002/ccd.28628. [Epub ahead of print]

PMID: 31778024

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  1. Suprasternal Pulmonary Artery Puncture in the Setting of Right-Sided Mechanical Prostheses: The Radner Technique Redux.

Miranda WR, Connolly HM, Hagler DJ.

JACC Cardiovasc Interv. 2019 Nov 25;12(22):2320-2321. doi: 10.1016/j.jcin.2019.05.036. Epub 2019 Oct 30. No abstract available.

PMID: 31678091

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  1. Assessment of the healing process after percutaneous implantation of a cardiovascular device: a systematic review.

Perdreau E, Jalal Z, Walton RD, Naulin J, Magat J, Quesson B, Cochet H, Bernus O, Thambo JB.

Int J Cardiovasc Imaging. 2019 Nov 19. doi: 10.1007/s10554-019-01734-2. [Epub ahead of print] Review.

PMID: 31745743

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  1. Characteristics of Patent Ductus Arteriosus in Congenital Rubella Syndrome.

Toizumi M, Do CGT, Motomura H, Do TN, Fukunaga H, Iijima M, Le NN, Nguyen HT, Moriuchi H, Yoshida LM.

Sci Rep. 2019 Nov 19;9(1):17105. doi: 10.1038/s41598-019-52936-6.

PMID: 31745134 Free PMC Article

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  1. Risk Factors and Predictors of Cardiac Erosion Discovered from 12 Japanese Patients Who Developed Erosion After Atrial Septal Defect Closure Using Amplatzer Septal Occluder.

Kitano M, Yazaki S, Sugiyama H, Ohtsuki SI, Tomita H.

Pediatr Cardiol. 2019 Nov 16. doi: 10.1007/s00246-019-02256-3. [Epub ahead of print]

PMID: 31732763

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  1. Impact of Chronic Thrombocytopenia on Outcomes After Transcatheter Valvular Intervention and Cardiac Devices Implantation (From a National Inpatient Sample).

Shokr M, Adegbala O, Elmoghrabi A, Saleh M, Ajam M, Ali A, Yassin AS, Ando T, Eperjesiova B, Aly A, Pahuja M, Ashraf S, Abubakar H, Ahmed A, Subahi A, Lieberman R, Afonso L.

Am J Cardiol. 2019 Nov 15;124(10):1601-1607. doi: 10.1016/j.amjcard.2019.08.012. Epub 2019 Aug 22.

PMID: 31522774

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  1. Initial experiences with a novel biodegradable device for percutaneous closure of atrial septal defects: From preclinical study to first-in-human experience.

Li YF, Xie YM, Chen J, Li BN, Xie ZF, Wang SS, Zhang ZW.

Catheter Cardiovasc Interv. 2019 Nov 12. doi: 10.1002/ccd.28529. [Epub ahead of print]

PMID: 31714687

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  1. Microcoils in Plug: Novel Rescue Technique for Residual Shunt After PDA Closure.

Shyu TC, Chuang CM, Tai IH, Chu KH, Fu YC.

JACC Cardiovasc Interv. 2019 Nov 11;12(21):e187-e188. doi: 10.1016/j.jcin.2019.06.051. Epub 2019 Oct 16. No abstract available.

PMID: 31629745

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  1. Balloon expandable covered stents as primary therapy for hemodynamically stable traumatic aortic injuries in children.

Hiremath G, Morgan G, Kenny D, Batlivala SP, Bartakian S.

Catheter Cardiovasc Interv. 2019 Nov 9. doi: 10.1002/ccd.28575. [Epub ahead of print]

PMID: 31705789

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  1. Invasive Cardiac Procedures in Interstage Single Ventricle Patients in Emergent Hospitalizations.

Haughey BS, White SC, Pacheco GS, Fox KA, Seckeler MD.

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PMID: 31705178

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  1. Hybrid transcatheter pulmonary valve replacement with a SAPIEN S3 valve after pulmonary artery banding via left lateral thoracotomy.

Serfas JD, Turek J, Haney J, Krasuski RA, Fleming GA.

Catheter Cardiovasc Interv. 2019 Nov 7. doi: 10.1002/ccd.28591. [Epub ahead of print]

PMID: 31696653

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  1. Failure to Rescue as an Outcome Metric for Pediatric and Congenital Cardiac Catheterization Laboratory Programs: Analysis of Data From the IMPACT Registry.

O’Byrne ML, Kennedy KF, Jayaram N, Bergersen LJ, Gillespie MJ, Dori Y, Silber JH, Kawut SM, Rome JJ, Glatz AC.

J Am Heart Assoc. 2019 Nov 5;8(21):e013151. doi: 10.1161/JAHA.119.013151. Epub 2019 Oct 17.

PMID: 31619106 Free Article

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  1. Transcatheter closure of right pulmonary artery to left atrium fistula in an infant: technical consideration and possible closure techniques.

Arya V, Azad S, Radhakrishnan S.

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PMID: 31679544

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  1. Trends in transcatheter and operative closure of patent ductus arteriosus in neonatal intensive care units: Analysis of data from the Pediatric Health Information Systems Database.

O’Byrne ML, Millenson ME, Grady CB, Huang J, Bamat NA, Munson DA, Song L, Dori Y, Gillespie MJ, Rome JJ, Glatz AC.

Am Heart J. 2019 Nov;217:121-130. doi: 10.1016/j.ahj.2019.08.009. Epub 2019 Aug 17.

PMID: 31654942

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  1. Clues to echocardiographic diagnosis of isolation of right subclavian artery in a patient with DiGeorge syndrome and its transcatheter management with its associated anomalies.

Mohakud AR, Pavithran S, Sivakumar K.

Cardiol Young. 2019 Nov;29(11):1397-1399. doi: 10.1017/S1047951119001963. Epub 2019 Sep 10.

PMID: 31500684

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  1. Percutaneous obliteration of the right ventricle to avoid coronary damage by sinusoids in patients with pulmonary atresia intact ventricular septum during staged single ventricle palliation.

Hubrechts J, Cools B, Brown SC, Eyskens B, Heying R, Boshoff D, Gewillig M.

Catheter Cardiovasc Interv. 2019 Nov 1;94(5):722-726. doi: 10.1002/ccd.28457. Epub 2019 Aug 21.

PMID: 31433549

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  1. Percutaneous ultrasound guided thrombin injection for axillary artery pseudoaneurysm following stenting of the arterial duct in two infants: Case report with review of literature.

Karmegaraj B, Prabhu N, Kappanayil M, Kumar RK.

Catheter Cardiovasc Interv. 2019 Nov 1;94(5):727-731. doi: 10.1002/ccd.28174. Epub 2019 Mar 9.

PMID: 30851076

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  1. Transcatheter closure of atrial septal defect in adults: time-course of atrial and ventricular remodeling and effects on exercise capacity.

Stephensen SS, Ostenfeld E, Kutty S, Steding-Ehrenborg K, Arheden H, Thilén U, Carlsson M.

Int J Cardiovasc Imaging. 2019 Nov;35(11):2077-2084. doi: 10.1007/s10554-019-01647-0. Epub 2019 Jun 15.

PMID: 31203534 Free PMC Article

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  1. Surgical Versus Percutaneous Closure of PDA in Preterm Infants: Procedural Charges and Outcomes.

Kim HS, Schechter MA, Manning PB, Eghtesady P, Balzer DT, Shahanavaz S, Rockefeller TA, Abarbanell AM.

J Surg Res. 2019 Nov;243:41-46. doi: 10.1016/j.jss.2019.04.069. Epub 2019 May 30.

PMID: 31154131

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  1. Cardiopulmonary Resuscitation in the Pediatric Cardiac Catheterization Laboratory: A Report From the American Heart Association’s Get With the Guidelines-Resuscitation Registry.

Lasa JJ, Alali A, Minard CG, Parekh D, Kutty S, Gaies M, Raymond TT, Guerguerian AM, Atkins D, Foglia E, Fink E, Roberts J, Duval-Arnould J, Bembea M, Kleinman M, Gupta P, Sutton R, Sawyer T; American Heart Association’s Get With the Guidelines-Resuscitation Investigators.

Pediatr Crit Care Med. 2019 Nov;20(11):1040-1047. doi: 10.1097/PCC.0000000000002038.

PMID: 31232852

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  1. Stroke After Cardiac Catheterization in Children.

Harrar DB, Salussolia CL, Vittner P, Danehy A, Sen S, Whitehill R, Chao JH, Bernson-Leung ME, Rivkin MJ.

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PMID: 31481331

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ACHD Surgery

CHD Surgery Nov 2019

  • Is a semi-elemental diet better than a polymeric diet after congenital heart surgery?
  • Rooze S, Namane SA, Beretta X, Vicinanza A, Vens D, Voglet C, Willems A, Goyens P, Biarent D.

    Eur J Pediatr. 2019 Nov 28. doi: 10.1007/s00431-019-03505-6. [Epub ahead of print]

    PMID: 31781932

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    1. Surgical treatment results of secondary tunnel-like subaortic stenosis after congenital heart disease operations: A 7-year, single-center experience in 25 patients.

    Zhang X, Wang W, Yan J, Wang Q.

    J Card Surg. 2019 Nov 25. doi: 10.1111/jocs.14369. [Epub ahead of print]

    PMID: 31765039

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    1. Trends in Infant Mortality After TAPVR Repair over 18 Years in Texas and Impact of Hospital Surgical Volume.

    Lahiri S, Wang Y, Caldarone CA, Morris SA.

    Pediatr Cardiol. 2019 Nov 22. doi: 10.1007/s00246-019-02224-x. [Epub ahead of print]

    PMID: 31758210

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    1. Remarkably Still Repairable Large Aortopulmonary Window in an Adult Patient.

    Zografos PM, Protopapas EM, Hakim NI, Alexopoulos C, Sarris GE.

    World J Pediatr Congenit Heart Surg. 2019 Nov 22:2150135119878703. doi: 10.1177/2150135119878703. [Epub ahead of print]

    PMID: 31755375

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    1. Utilization and Outcomes of Children Treated with Direct Thrombin Inhibitors on Paracorporeal Ventricular Assist Device Support.

    VanderPluym CJ, Cantor RS, Machado D, Boyle G, May L, Griffiths E, Niebler RA, Lorts A, Rossano J, Sutcliffe DL, Lytrivi ID, Buchholz H, Fynn-Thompson F, Hawkins B, Conway J.

    ASAIO J. 2019 Nov 20. doi: 10.1097/MAT.0000000000001093. [Epub ahead of print]

    PMID: 31789654

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    1. Providing a framework of principles for conceptualising the Fontan Circulation.

    Gewillig M, Brown SC, van de Bruaene A, Rychik J.

    Acta Paediatr. 2019 Nov 18. doi: 10.1111/apa.15098. [Epub ahead of print] Review.

    PMID: 31737940

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    1. Outcomes following modified extracardiac Fontan procedure of direct total cavopulmonary connection with autologous vessels: a single-centre 10-year experience.

    Liu X, Yuan H, Chen J, Cen J, Nie Z, Xu G, Wen S, Zhuang J.

    Eur J Cardiothorac Surg. 2019 Nov 18. pii: ezz310. doi: 10.1093/ejcts/ezz310. [Epub ahead of print]

    PMID: 31740945

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    1. Retrosternal Clots After Fontan Surgery by Systematic Evaluation With Transthoracic Ultrasound.

    Cantinotti M, Giordano R, Marchese P, Franchi E, Viacava C, Pak V, Murzi B, Arcieri L, Poli V, Federici D, Koestenberger M, Assanta N.

    J Cardiothorac Vasc Anesth. 2019 Nov 18. pii: S1053-0770(19)31156-5. doi: 10.1053/j.jvca.2019.11.009. [Epub ahead of print]

    PMID: 31812566

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    1. “The heart supporters”: systematic review for ventricle assist devices in congenital heart surgery.

    Comentale G, Giordano R, Pilato E, D’Amore A, Romano R, Simeone S, Browning R, Palma G, Iannelli G.

    Heart Fail Rev. 2019 Nov 16. doi: 10.1007/s10741-019-09892-0. [Epub ahead of print] Review.

    PMID: 31734755

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    1. Excess nonhemorrhagic pleural drainage after surgery for congenital heart diseases: Single center experience.

    Elassal AA, Al-Radi OO, Dohain AM, Abdelmohsen GA, Al-Ebrahim KE, Eldib OS.

    J Card Surg. 2019 Nov 15. doi: 10.1111/jocs.14338. [Epub ahead of print]

    PMID: 31730717

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    1. Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery.

    Zloto K, Tirosh-Wagner T, Bolkier Y, Bar-Yosef O, Vardi A, Mishali D, Paret G, Nevo-Caspi Y.

    J Cardiovasc Transl Res. 2019 Nov 15. doi: 10.1007/s12265-019-09921-1. [Epub ahead of print]

    PMID: 31732917

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    1. Three Stage Hybrid Approach for Congenital Aortic Coarctation and Bicuspid Aortic Valve With Severe Aortic Stenosis in an Adult Patient.

    Matsumoto MM, Milner R.

    EJVES Short Rep. 2019 Nov 12;45:26-29. doi: 10.1016/j.ejvssr.2019.10.003. eCollection 2019.

    PMID: 31768425 Free PMC Article

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    1. Predictors of neuropsychological functioning and medication adherence in pediatric heart transplant recipients referred for neuropsychological evaluation.

    Wolfe KR, Kelly SL, Steinberg E, Pliego J, Everitt MD.

    Pediatr Transplant. 2019 Nov 12:e13615. doi: 10.1111/petr.13615. [Epub ahead of print]

    PMID: 31713990

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    1. Utilization of inhaled nitric oxide after surgical repair of truncus arteriosus: A multicenter analysis.

    Riley CM, Mastropietro CW, Sassalos P, Buckley JR, Costello JM, Iliopoulos I, Jennings A, Cashen K, Suguna Narasimhulu S, Gowda KMN, Smerling AJ, Wilhelm M, Badheka A, Bakar A, Moser EAS, Amula V.

    Congenit Heart Dis. 2019 Nov 11. doi: 10.1111/chd.12849. [Epub ahead of print]

    PMID: 31713327

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    1. Scoliosis Correction with One Ventricle: A Multispecialty Approach.

    Bustillo MA, Hussain I, Virk MS, Fu KM, Scharoun JH.

    World Neurosurg. 2019 Nov 9;134:302-307. doi: 10.1016/j.wneu.2019.11.004. [Epub ahead of print]

    PMID: 31715418

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    1. Risk Factors for Prolonged Pleural Effusion Following Total Cavopulmonary Connection Surgery: 9 Years’ Experience at Fuwai Hospital.

    Luo Q, Zhao W, Su Z, Liu Y, Jia Y, Zhang L, Wang H, Li Y, Wu X, Li S, Yan F.

    Front Pediatr. 2019 Nov 7;7:456. doi: 10.3389/fped.2019.00456. eCollection 2019.

    PMID: 31788459 Free PMC Article

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    1. The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation.

    Koski TK, Suominen PK, Raissadati A, Knihtilä HM, Ojala TH, Salminen JT.

    Acta Anaesthesiol Scand. 2019 Nov;63(10):1384-1389. doi: 10.1111/aas.13431. Epub 2019 Jul 16.

    PMID: 31271655

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    1. Outcomes Associated With Unplanned Interstage Cardiac Interventions After Norwood Palliation.

    Castellanos DA, Ocampo EC, Gooden A, Wang Y, Qureshi AM, Heinle JS, Mery CM, Hill GD, Ghanayem NS.

    Ann Thorac Surg. 2019 Nov;108(5):1423-1429. doi: 10.1016/j.athoracsur.2019.06.041. Epub 2019 Aug 7.

    PMID: 31400339

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    1. Congenital Heart Surgery Outcomes in Turner Syndrome: The Society of Thoracic Surgeons Database Analysis.

    Chew JD, Hill KD, Jacobs ML, Jacobs JP, Killen SAS, Godown J, Wallace AS, Thibault D, Chiswell K, Bichell DP, Soslow JH.

    Ann Thorac Surg. 2019 Nov;108(5):1430-1437. doi: 10.1016/j.athoracsur.2019.05.047. Epub 2019 Jul 9.

    PMID: 31299232

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    1. Contemporary Outcomes of the Fontan Operation: A Large Single-Institution Cohort.

    Mery CM, De León LE, Trujillo-Diaz D, Ocampo EC, Dickerson HA, Zhu H, Adachi I, Heinle JS, Fraser CD Jr, Ermis PR.

    Ann Thorac Surg. 2019 Nov;108(5):1439-1446. doi: 10.1016/j.athoracsur.2019.05.039. Epub 2019 Jul 4.

    PMID: 31279788

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    1. Reoperation after isolated subaortic membrane resection.

    Binsalamah ZM, Spigel ZA, Zhu H, Kim MB, Chacon-Portillo MA, Adachi I, Imamura M, Mery CM, Mckenzie ED, Fraser CD, Heinle JS.

    Cardiol Young. 2019 Nov;29(11):1391-1396. doi: 10.1017/S1047951119002336. Epub 2019 Sep 26.

    PMID: 31554530

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    1. Kidney Disease: Improving Global Outcomes in neonates with acute kidney injury after cardiac surgery.

    Ueno K, Shiokawa N, Takahashi Y, Nakae K, Kawamura J, Imoto Y, Kawano Y.

    Clin Exp Nephrol. 2019 Nov 1. doi: 10.1007/s10157-019-01805-7. [Epub ahead of print]

    PMID: 31677063

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    1. “Echo pause” for postoperative transthoracic echocardiographic surveillance.

    Cox K, Arunamata A, Krawczeski CD, Reddy C, Kipps AK, Long J, Roth SJ, Axelrod DM, Hanley F, Shin A, Selamet Tierney ES.

    Echocardiography. 2019 Nov;36(11):2078-2085. doi: 10.1111/echo.14505. Epub 2019 Oct 19.

    PMID: 31628768

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    1. Comparison of outcomes of pulmonary valve replacement in adult versus paediatric hospitals: institutional influence†.

    Fuller S, Ramachandran A, Awh K, Faerber JA, Patel PA, Nicolson SC, O’Byrne ML, Mascio CE, Kim YY.

    Eur J Cardiothorac Surg. 2019 Nov 1;56(5):891-897. doi: 10.1093/ejcts/ezz102.

    PMID: 30957859

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    1. Application of decellularized allograft for primary repair of congenital heart disease in Japan.

    Ozawa H, Ueno T, Taira M, Toda K, Kuratani T, Sawa Y.

    Gen Thorac Cardiovasc Surg. 2019 Nov;67(11):976-978. doi: 10.1007/s11748-018-0988-9. Epub 2018 Aug 13.

    PMID: 30101363

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    1. Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation.

    van der Palen RLF, van der Bom T, Dekker A, Tsonaka R, van Geloven N, Kuipers IM, Konings TC, Rammeloo LAJ, Ten Harkel ADJ, Jongbloed MRM, Koolbergen DR, Mulder BJM, Hazekamp MG, Blom NA.

    Heart. 2019 Nov;105(22):1732-1740. doi: 10.1136/heartjnl-2019-315157. Epub 2019 Jul 10.

    PMID: 31292191 Free PMC Article

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    1. Vacuum-assisted closure versus closed irrigation for deep sternal wound infection treatment in infants: a propensity score-matched study.

    Ivanzov S, Soynov I, Kulyabin Y, Zubritskiy A, Voitov A, Omelchenko A, Arkhipov A, Bogachev-Prokophiev A.

    Interact Cardiovasc Thorac Surg. 2019 Nov 1;29(5):776-782. doi: 10.1093/icvts/ivz167.

    PMID: 31361302

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    1. Arterial switch operation for transposition of the great arteries: A single-centre 32-year experience.

    Vida VL, Zanotto L, Zanotto L, Triglia LT, Bellanti E, Castaldi B, Padalino MA, Gasperetti A, Battista F, Varnier M, Stellin G.

    J Card Surg. 2019 Nov;34(11):1154-1161. doi: 10.1111/jocs.14045. Epub 2019 Sep 11.

    PMID: 31508848

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    1. Giant aneurysm of the right atrial appendage repaired by minimally invasive approach.

    Hiraoka A, Tachibana H, Yoshitaka H, Sakaguchi T.

    J Card Surg. 2019 Nov;34(11):1352-1353. doi: 10.1111/jocs.14206. Epub 2019 Sep 3.

    PMID: 31478249

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    Select item 31449703

     

    1. Repair of anomalous origin of left coronary artery without intramural course using an ultrasonic scalpel.

    Nam LL, Zimmerman SL, Sekar P, Hibino N.

    J Card Surg. 2019 Nov;34(11):1380-1382. doi: 10.1111/jocs.14213. Epub 2019 Aug 26. No abstract available.

    PMID: 31449693

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    1. Three-dimensional printing for surgical planning in complex congenital heart disease.

    Vettukattil JJ, Mohammad Nijres B, Gosnell JM, Samuel BP, Haw MP.

    J Card Surg. 2019 Nov;34(11):1363-1369. doi: 10.1111/jocs.14180. Epub 2019 Aug 26.

    PMID: 31449687

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    1. First pediatric HeartMate 3 implantation: US experience.

    Bansal A, Akhtar F, Zwintscher NP, Young T, Patel R, Desai S.

    J Card Surg. 2019 Nov;34(11):1383-1386. doi: 10.1111/jocs.14216. Epub 2019 Aug 17.

    PMID: 31421654

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    1. Aortic recoarctation and pseudoaneurysm five decades after repair.

    Lim B, Forest SJ, Schultz ML, Lipsitz E, Michler RE.

    J Card Surg. 2019 Nov;34(11):1374-1376. doi: 10.1111/jocs.14201. Epub 2019 Aug 17.

    PMID: 31421653

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    1. Structured review of post-cardiotomy extracorporeal membrane oxygenation: Part 2-pediatric patients.

    Lorusso R, Raffa GM, Kowalewski M, Alenizy K, Sluijpers N, Makhoul M, Brodie D, McMullan M, Wang IW, Meani P, MacLaren G, Dalton H, Barbaro R, Hou X, Cavarocchi N, Chen YS, Thiagarajan R, Alexander P, Alsoufi B, Bermudez CA, Shah AS, Haft J, Oreto L, D’Alessandro DA, Boeken U, Whitman G.

    J Heart Lung Transplant. 2019 Nov;38(11):1144-1161. doi: 10.1016/j.healun.2019.07.004. Epub 2019 Jul 17.

    PMID: 31421976

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    1. Avoidance of malignant arrhythmia caused by displacement of the right coronary artery ostium in surgical correction of supravalvular aortic stenosis.

    Peng B, Wang Q.

    J Int Med Res. 2019 Nov;47(11):5702-5710. doi: 10.1177/0300060518818021. Epub 2019 Sep 26. No abstract available.

    PMID: 31558080 Free PMC Article

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    1. Neurologic outcomes after heart surgery.

    Fang A, Allen KY, Marino BS, Brady KM.

    Paediatr Anaesth. 2019 Nov;29(11):1086-1093. doi: 10.1111/pan.13744. Epub 2019 Oct 8. No abstract available.

    PMID: 31532867

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    1. Is Doppler echocardiography useful for estimating left ventricular filling pressures in pediatric heart transplant recipients?

    Lunze FI, Narciso R, Gauvreau K, Blume ED, Colan SD, Singh TP.

    Pediatr Transplant. 2019 Nov;23(7):e13543. doi: 10.1111/petr.13543. Epub 2019 Jul 16.

    PMID: 31313435

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    1. Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry “MYKKE”.

    Schubert S, Opgen-Rhein B, Boehne M, Weigelt A, Wagner R, Müller G, Rentzsch A, Zu Knyphausen E, Fischer M, Papakostas K, Wiegand G, Ruf B, Hannes T, Reineker K, Kiski D, Khalil M, Steinmetz M, Fischer G, Pickardt T, Klingel K, Messroghli DR, Degener F; MYKKE consortium.

    Pediatr Transplant. 2019 Nov;23(7):e13548. doi: 10.1111/petr.13548. Epub 2019 Jul 11.

    PMID: 31297930

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    Select item 31601612

     

    1. Electroencephalographic patterns preceding cardiac arrest in neonates following cardiac surgery.

    Massey SL, Abend NS, Gaynor JW, Licht DJ, Nadkarni VM, Topjian AA, Xiao R, Naim MY.

    Resuscitation. 2019 Nov;144:67-74. doi: 10.1016/j.resuscitation.2019.09.005. Epub 2019 Sep 24.

    PMID: 31560988

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    1. Aortic Valve Neo-Cuspidization in Children – Ready for Prime Time Yet?

    Goldberg R, Kumar SR.

    World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):731-732. doi: 10.1177/2150135119883622. No abstract available.

    PMID: 31701839

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    1. The Konno Operation Is a Durable Option for Relief of Aortic Stenosis in Patients With Complex Left Ventricular Outflow Tract Obstruction-A Single-Center 20-Year Experience.

    Matsushima S, Burri M, Strbad M, Ruf B, Lange R, Hörer J, Cleuziou J.

    World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):678-685. doi: 10.1177/2150135119872476.

    PMID: 31701836

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    1. Intermediate Outcomes of Staged Tetralogy of Fallot Repair.

    Mahajan P, Ebenroth ES, Borsheim K, Husain S, Bo N, Herrmann JL, Rodefeld MD, Turrentine MW, Brown JW, Patel JK.

    World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):694-701. doi: 10.1177/2150135119874035.

    PMID: 31701830

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    1. Congenital Cardiac Surgery and Parental Perception of Risk: A Quantitative Analysis.

    Lotto R, Jones I, Seaton SE, Dhannapuneni R, Guerrero R, Lotto A.

    World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):669-677. doi: 10.1177/2150135119872489.

    PMID: 31701827

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    1. The Ozaki Procedure With CardioCel Patch for Children and Young Adults With Aortic Valve Disease: Preliminary Experience – a Word of Caution.

    Chivers SC, Pavy C, Vaja R, Quarto C, Ghez O, Daubeney PEF.

    World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):724-730. doi: 10.1177/2150135119878108.

    PMID: 31701826

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    1. Modified Septostomy in d-Transposition of Great Arteries With Aneurysmal and Intact Atrial Septum.

    Mylonas KS, Tzifa A.

    World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):789-790. doi: 10.1177/2150135119872207.

    PMID: 31701823

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    1. Cardiac Collapse Secondary to Phenytoin Toxicity in a Neonate Treated with Extracorporeal Membrane Oxygenation Support (ECMO).

    Knecht M, LaRochelle J, Barkemeyer B, Gupta R, Brumund M, Mumphrey C.

    J Med Toxicol. 2019 Nov 26. doi: 10.1007/s13181-019-00742-x. [Epub ahead of print]

    PMID: 31773636

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    1. Failure of Cellularization of Ventriculotomy Patch Leading to Right Ventricular Pseudoaneurysm.

    Rao S, Stewart RD, Pettersson G, Tan C, Golz S, Komarlu R.

    World J Pediatr Congenit Heart Surg. 2019 Nov 22:2150135119880547. doi: 10.1177/2150135119880547. [Epub ahead of print]

    PMID: 31755355

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    1. Center Variation in Chest Tube Duration and Length of Stay After Congenital Heart Surgery.

    Bates KE, Madsen NL, Khadr L, Gao Z, Crawford K, Gaies M, Graupe M, Hanke SP, Hlavacek AM, Morell E, Pasquali SK, Russell JL, Schachtner SK, Tanel RE, Ware AL, Kipps AK.

    Ann Thorac Surg. 2019 Nov 21. pii: S0003-4975(19)31710-2. doi: 10.1016/j.athoracsur.2019.09.078. [Epub ahead of print]

    PMID: 31760054

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    1. Palliative Care Engagement for Pediatric Ventricular Assist Device Patients: A Single-Center Experience.

    Knoll C, Kaufman B, Chen S, Murray J, Cohen H, Sourkes BM, Rosenthal DN, Hollander SA.

    ASAIO J. 2019 Nov 20. doi: 10.1097/MAT.0000000000001092. [Epub ahead of print]

    PMID: 31789655

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    1. Excess nonhemorrhagic pleural drainage after surgery for congenital heart diseases: Single center experience.

    Elassal AA, Al-Radi OO, Dohain AM, Abdelmohsen GA, Al-Ebrahim KE, Eldib OS.

    J Card Surg. 2019 Nov 15. doi: 10.1111/jocs.14338. [Epub ahead of print]

    PMID: 31730717

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    1. Heart Transplantation in Children with Mitochondrial Disease.

    Weiner JG, Lambert AN, Thurm C, Hall M, Soslow JH, Reimschisel TE, Bearl DW, Dodd DA, Feingold B, Godown J.

    J Pediatr. 2019 Nov 8. pii: S0022-3476(19)31339-3. doi: 10.1016/j.jpeds.2019.10.016. [Epub ahead of print]

    PMID: 31711761

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    1. Implantation of a HeartMate 3 in a 13-Year-Old Child with Dilated Cardiomyopathy.

    Pfister R, Kirsch M, Natterer J, Di Bernardo S, Pretre R.

    Pediatr Cardiol. 2019 Nov 2. doi: 10.1007/s00246-019-02229-6. [Epub ahead of print]

    PMID: 31679056

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    1. Late Survival and Patient-Perceived Health Status of the Congenital Heart Surgeons’ Society dextro-Transposition of the Great Arteries Cohort.

    Devlin PJ, Jegatheeswaran A, Williams WG, Blackstone EH, DeCampli WM, Lambert LM, Mussatto KA, Prospero CJ, Bondarenko I, McCrindle BW.

    Ann Thorac Surg. 2019 Nov;108(5):1447-1455. doi: 10.1016/j.athoracsur.2019.05.081. Epub 2019 Jul 23.

    PMID: 31348901

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    1. Contemporary Outcomes of the Fontan Operation: A Large Single-Institution Cohort.

    Mery CM, De León LE, Trujillo-Diaz D, Ocampo EC, Dickerson HA, Zhu H, Adachi I, Heinle JS, Fraser CD Jr, Ermis PR.

    Ann Thorac Surg. 2019 Nov;108(5):1439-1446. doi: 10.1016/j.athoracsur.2019.05.039. Epub 2019 Jul 4.

    PMID: 31279788

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    1. Warden Procedure in a 77-Year-Old Man.

    Hopkins KA, Farber MO, Singh R, Kay WA, Herrmann JL, Brown JW.

    Ann Thorac Surg. 2019 Nov;108(5):e319-e321. doi: 10.1016/j.athoracsur.2019.02.049. Epub 2019 Mar 25.

    PMID: 30922823

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    1. Ahead of his time: Gross’ first successful ligation of a patent ductus arteriosus.

    Mazurak M, Kusa J.

    Arch Dis Child. 2019 Nov;104(11):1096-1097. doi: 10.1136/archdischild-2018-315288. Epub 2018 Aug 29. No abstract available.

    PMID: 30158137

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    Select item 31162850

     

    1. New versatile dual-support pediatric heart pump.

    Fox C, Sarkisyan H, Stevens R, Arabia F, Fischer W, Rossano J, Throckmorton A.

    Artif Organs. 2019 Nov;43(11):1055-1064. doi: 10.1111/aor.13507. Epub 2019 Jul 16.

    PMID: 31162850

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    Select item 30325847

     

    1. Double drainage of pulmonary vein associated with atrial septal defect.

    Yılmaz M, Ziadinov E, Aykan HH.

    Asian Cardiovasc Thorac Ann. 2019 Nov;27(9):776-778. doi: 10.1177/0218492319863600. Epub 2019 Jul 9. No abstract available.

    PMID: 31288550

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    Select item 31072104

     

    1. Adams-Stokes attack with delayed heart block after ventricular septal repair.

    Chaiyakulsil C, Sirichongkolthong B.

    Asian Cardiovasc Thorac Ann. 2019 Nov;27(9):760-763. doi: 10.1177/0218492319851380. Epub 2019 May 9. No abstract available.

    PMID: 31072104

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    Select item 31391347

     

    1. First pediatric HeartMate 3 implantation: US experience.

    Bansal A, Akhtar F, Zwintscher NP, Young T, Patel R, Desai S.

    J Card Surg. 2019 Nov;34(11):1383-1386. doi: 10.1111/jocs.14216. Epub 2019 Aug 17.

    PMID: 31421654

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    1. Commentary: Fontan assist device support: Road map to “stage 4” palliation.

    Broda CR, Adachi I.

    J Thorac Cardiovasc Surg. 2019 Nov;158(5):1422-1423. doi: 10.1016/j.jtcvs.2019.06.101. Epub 2019 Aug 8. No abstract available.

    PMID: 31493880

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    1. Hospital readmission following pediatric heart transplantation.

    Mahle WT, Mason KL, Dipchand AI, Richmond M, Feingold B, Canter CE, Hsu DT, Singh TP, Shaddy RE, Armstrong BD, Zeevi A, Iklé DN, Diop H, Odim J, Webber SA; CTOTC-04 Investigators.

    Pediatr Transplant. 2019 Nov;23(7):e13561. doi: 10.1111/petr.13561. Epub 2019 Sep 4.

    PMID: 31483086

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    1. The Konno Operation Is a Durable Option for Relief of Aortic Stenosis in Patients With Complex Left Ventricular Outflow Tract Obstruction-A Single-Center 20-Year Experience.

    Matsushima S, Burri M, Strbad M, Ruf B, Lange R, Hörer J, Cleuziou J.

    World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):678-685. doi: 10.1177/2150135119872476.

    PMID: 31701836

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    1. Tetralogy of Fallot With Interatrial Communication of the Inferior Sinus Venosus Type: A Rare Association Causing Post-Operative Desaturation.

    Agrawal G, Das A.

    World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):801-802. doi: 10.1177/2150135119874033.

    PMID: 31701832

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    1. Developments in Pediatric Ventricular Assist Device Support.

    Tume SC, Conway J, Ryan KR, Philip J, Fortkiewicz JM, Murray J.

    World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):759-768. doi: 10.1177/2150135119880890. Epub 2019 Oct 30.

    PMID: 31663841

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    Fetal Cardiology Featured Articles

    Fetal cardiology and genetics Nov 2019

  • Return of genetic and genomic research findings: experience of a pediatric biorepository.
  • Papaz T, Liston E, Zahavich L, Stavropoulos DJ, Jobling RK, Kim RH, Reuter M, Miron A, Oechslin E, Mondal T, Bergin L, Smythe JF, Altamirano-Diaz L, Lougheed J, Yao R, Akinrinade O, Breckpot J, Mital S.

    BMC Med Genomics. 2019 Nov 27;12(1):173. doi: 10.1186/s12920-019-0618-0.

    PMID: 31775751 Free PMC Article

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    1. Xenopus: Experimental Access to Cardiovascular Development, Regeneration Discovery, and Cardiovascular Heart-Defect Modeling.

    Hoppler S, Conlon FL.

    Cold Spring Harb Perspect Biol. 2019 Nov 25. pii: a037200. doi: 10.1101/cshperspect.a037200. [Epub ahead of print]

    PMID: 31767648

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    1. Serial fetal echocardiograms in hypoplastic left heart syndrome fetuses: Does it affect immediate post-natal care?

    Richards B, Freel L, Stiver C, Texter K, Cua CL.

    Int J Cardiol. 2019 Nov 21. pii: S0167-5273(19)33617-4. doi: 10.1016/j.ijcard.2019.11.119. [Epub ahead of print]

    PMID: 31785958

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    1. Inositol 1,4,5-trisphosphate receptor 2 as a novel marker of vasculature to delineate processes of cardiopulmonary development.

    Ishizaki-Asami R, Uchida K, Tsuchihashi T, Shibata A, Kodo K, Emoto K, Mikoshiba K, Takahashi T, Yamagishi H.

    Dev Biol. 2019 Nov 20. pii: S0012-1606(19)30477-4. doi: 10.1016/j.ydbio.2019.11.011. [Epub ahead of print]

    PMID: 31758944

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    1. Impaired Fetal Environment and Gestational Age: What Is Driving Mortality in Neonates With Critical Congenital Heart Disease?

    Steurer MA, Peyvandi S, Baer RJ, Oltman SP, Chambers CD, Norton ME, Ryckman KK, Moon-Grady AJ, Keller RL, Shiboski SC, Jelliffe-Pawlowski LL.

    J Am Heart Assoc. 2019 Nov 19;8(22):e013194. doi: 10.1161/JAHA.119.013194. Epub 2019 Nov 15.

    PMID: 31726960 Free Article

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    Select item 31718438

     

    1. G9α-dependent histone H3K9me3 hypomethylation promotes overexpression of cardiomyogenesis-related genes in foetal mice.

    Peng B, Han X, Peng C, Luo X, Deng L, Huang L.

    J Cell Mol Med. 2019 Nov 19. doi: 10.1111/jcmm.14824. [Epub ahead of print]

    PMID: 31746096 Free Article

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    Select item 31744358

     

    1. In fetuses with congenital lung masses, decreased ventricular and atrioventricular valve dimensions are associated with lesion size and clinical outcome.

    Mardy C, Blumenfeld YJ, Arunamata AA, Girsen AI, Sylvester KG, Halabi S, Rubesova E, Hintz SR, Tacy TA, Maskatia SA.

    Prenat Diagn. 2019 Nov 19. doi: 10.1002/pd.5612. [Epub ahead of print]

    PMID: 31742724

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    Select item 31743523

     

    1. Transplacental metoprolol for fetal supraventricular tachycardia.

    Vigneswaran TV, Rosenthal E, Bakalis S, Nelson-Piercy C, Chappell L, Simpson JM.

    Ultrasound Obstet Gynecol. 2019 Nov 19. doi: 10.1002/uog.21924. [Epub ahead of print] No abstract available.

    PMID: 31743523

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    Select item 31737940

     

    1. Prenatally Diagnosed Congenital Ventricular Outpouchings: An Institutional Experience and Review of the Literature.

    Shuplock JM, Kavanaugh-McHugh A, Parra D.

    Pediatr Cardiol. 2019 Nov 14. doi: 10.1007/s00246-019-02252-7. [Epub ahead of print]

    PMID: 31728571

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    Select item 31742315

     

    1. The effect of beta-blockers on foetal birth weight in pregnancies in women with structural heart disease: a prospective cohort study.

    Baard J, Azibani F, Osman A, Dowling W, Rayner B, Sliwa K.

    Cardiovasc J Afr. 2019 Nov 13;30:1-6. doi: 10.5830/CVJA-2019-061. [Epub ahead of print]

    PMID: 31742315 Free Article

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    Select item 31722548

     

    1. Translating genomic testing results for pediatric critical care: Opportunities for genetic counselors.

    Deuitch N, Soo-Jin Lee S, Char D.

    J Genet Couns. 2019 Nov 7. doi: 10.1002/jgc4.1182. [Epub ahead of print]

    PMID: 31701594

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    Select item 31734303

     

    1. Mesenchymal Stromal Cells from Patients with Cyanotic Congenital Heart Disease are Optimal Candidate for Cardiac Tissue Engineering.

    Kang K, Chuai JB, Xie BD, Li JZ, Qu H, Wu H, Fang SH, Cui JJ, Xiu LL, Han JC, Cao TH, Leng XP, Tian H, Li RK, Jiang SL.

    Biomaterials. 2019 Nov 6:119574. doi: 10.1016/j.biomaterials.2019.119574. [Epub ahead of print]

    PMID: 31761487

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    Select item 31709041

     

    1. Hemodynamic Responses of the Placenta and Brain to Maternal Hyperoxia in Fetuses with Congenital Heart Disease by Using Blood Oxygen-Level Dependent MRI.

    You W, Andescavage NN, Kapse K, Donofrio MT, Jacobs M, Limperopoulos C.

    Radiology. 2019 Nov 5:190751. doi: 10.1148/radiol.2019190751. [Epub ahead of print]

    PMID: 31687920

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    Select item 31679544

     

    1. Genome-wide association studies of structural birth defects: A review and commentary.

    Lupo PJ, Mitchell LE, Jenkins MM.

    Birth Defects Res. 2019 Nov 1;111(18):1329-1342. doi: 10.1002/bdr2.1606. Epub 2019 Oct 25. Review.

    PMID: 31654503

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    Select item 31580536

     

    1. Novel Mutation in MYH6 in 2 Unrelated Chinese Han Families With Familial Atrial Septal Defect.

    Xia Y, Chen S, Yang Y, Wu Y, Huang S, Wang Y, Ding H, He W, Li P, Zhuang J.

    Circ Genom Precis Med. 2019 Nov;12(11):e002732. doi: 10.1161/CIRCGEN.119.002732. Epub 2019 Oct 22. No abstract available.

    PMID: 31638415

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    Select item 31658832

     

    1. Prenatal diagnosis of tetralogy of Fallot associated with pulmonary artery sling: Two case reports.

    Li T, Han J, Gao S, Hao X, He Y.

    Echocardiography. 2019 Nov;36(11):2114-2117. doi: 10.1111/echo.14513. Epub 2019 Nov 8.

    PMID: 31705550

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    Select item 31628768

     

    1. Prenatal therapy for fetal cardiac disorders.

    Kumar S, Lodge J.

    J Matern Fetal Neonatal Med. 2019 Nov;32(22):3871-3881. doi: 10.1080/14767058.2018.1472224. Epub 2018 May 15.

    PMID: 29716424

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    Select item 31404639

     

    1. Risk Stratification of Fetal Cardiac Anomalies in an Underserved Population Using Telecardiology.

    Cuneo BF, Olson CA, Haxel C, Howley L, Gagnon A, Benson DW, Kaizer AM, Thomas JF.

    Obstet Gynecol. 2019 Nov;134(5):1096-1103. doi: 10.1097/AOG.0000000000003502.

    PMID: 31599844

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    1. The added value of screening fetal echocardiography after normal cardiac views on a detailed ultrasound.

    Cawyer CR, Kuper SG, Ausbeck E, Sinkey RG, Owen J.

    Prenat Diagn. 2019 Nov;39(12):1148-1154. doi: 10.1002/pd.5557. Epub 2019 Sep 13.

    PMID: 31499581

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    1. Using speckle-tracking echocardiography to assess fetal myocardial deformation: are we there yet?

    Day TG, Charakida M, Simpson JM.

    Ultrasound Obstet Gynecol. 2019 Nov;54(5):575-581. doi: 10.1002/uog.20233. No abstract available.

    PMID: 30740804

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    1. Spontaneous resolution of large pericardial effusion associated with right ventricular outpouching in four fetuses.

    Zidere V, Gebb J, Vigneswaran T, Charakida M, Simpson JM, Bower S.

    Ultrasound Obstet Gynecol. 2019 Nov;54(5):701-702. doi: 10.1002/uog.20194. No abstract available.

    PMID: 30549363

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    1. Bovine aortic arch: Prevalence in human fetuses.

    Goldsher YW, Salem Y, Weisz B, Achiron R, Jacobson JM, Gindes L.

    J Clin Ultrasound. 2019 Nov 28. doi: 10.1002/jcu.22800. [Epub ahead of print]

    PMID: 31777971

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    1. Risk Factors and Outcomes of Tetralogy of Fallot: From Fetal to Neonatal Life.

    Silva JA, Neves AL, Flor-de-Lima F, Soares P, Guimarães H.

    Pediatr Cardiol. 2019 Nov 25. doi: 10.1007/s00246-019-02239-4. [Epub ahead of print]

    PMID: 31768578

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    1. Prenatal Identification of Restrictive and Non-restrictive Ventricular Septal Defects Based on End-Systolic Flow Patterns in the Fetal Aortic Isthmus.

    Fouron JC, Thomas-Chabaneix J, Brisebois S, Berger A, Dahdah N.

    Pediatr Cardiol. 2019 Nov 16. doi: 10.1007/s00246-019-02257-2. [Epub ahead of print]

    PMID: 31732764

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    1. Left Superior Vena Cava in the Fetus: A Rarely Isolated Anomaly.

    Minsart AF, Boucoiran I, Delrue MA, Audibert F, Abadir S, Lapierre C, Lemyre E, Raboisson MJ.

    Pediatr Cardiol. 2019 Nov 13. doi: 10.1007/s00246-019-02246-5. [Epub ahead of print]

    PMID: 31720744

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    1. Cardiac hemodynamics in fetuses with transposition of the great arteries and intact ventricular septum from diagnosis to end of pregnancy: a longitudinal follow-up.

    Lachaud M, Dionne A, Brassard M, Charron MA, Birca A, Dehaes M, Raboisson MJ.

    Ultrasound Obstet Gynecol. 2019 Nov 11. doi: 10.1002/uog.21920. [Epub ahead of print]

    PMID: 31710736

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    1. Merged bilateral arterial duct and circumflex retroesophageal right aortic arch in a fetus with normal intracardiac anatomy.

    Bichali S, Grigorescu RC, Lefebvre M, Oriot C, Dhombres F, Bonnet D, Houyel L.

    Cardiol Young. 2019 Nov 4:1-3. doi: 10.1017/S1047951119002488. [Epub ahead of print]

    PMID: 31679548

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    1. Transposition of the great arteries: Fetal pulmonary valve growth and postoperative neo-aortic root dilatation.

    van der Palen RLF, van der Zee C, Vink AS, Knobbe I, Jurgens SJ, van Leeuwen E, Bax CJ, du Marchie Sarvaas GJ, Blom NA, Haak MC, Bilardo CM, Clur SB.

    Prenat Diagn. 2019 Nov;39(12):1054-1063. doi: 10.1002/pd.5539. Epub 2019 Aug 7.

    PMID: 31351016

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    Congenital Cardiovascular Anesthesia and Critical Care Featured Articles

    Congenital Heart and Pediatric Cardiac Anesthesia and Intensive Care Reviews for December 2019

    Modified Lung Ultrasound Examinations in Assessment and Monitoring of Positive End-Expiratory Pressure-Induced Lung Reaeration in Young Children With Congenital Heart Disease Under General Anesthesia.

    Wu L, Hou Q, Bai J, Zhang J, Sun L, Tan R, Zhang M, Zheng J.

    Pediatr Crit Care Med. 2019 May;20(5):442-449. doi: 10.1097/PCC.0000000000001865.

    PMID:  31058784

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    Take Home Points: 

    • The most prevalent region of post-intubation atelectasis in pediatric patients (3 months to 3 years old) undergoing pediatric cardiac surgery under general anesthesia is the posterior inferior region of the lung. Lung ultrasound (LUS) along the posterior axillary line at the intercostal fifth, sixth, and seventh spaces showed an incidence of atelectasis of 60-62.5%, 57.5-60% and 37.5% respectively, whereas LUS in the anterior or lateral regions rarely presented atelectasis (0-7.5%).
    • Post-intubation addition of 5 cm H2O positive end-expiratory pressure (PEEP) in pressure-controlled ventilated pediatric patients under general anesthesia significantly reduced the incidence of atelectasis in high prevalence areas of the lung (posterior and inferior). This simple beneficial intervention can improve lung aeration and decreases the incidence of postoperative atelectasis. In addition, this low level PEEP was not associated with hemodynamic compromise in pediatric cardiac patients.

    Commentary by Pablo Motta, MD a pediatric cardiac anesthesiologist at Texas Children’s Hospital in Houston Texas / Baylor College of Medicine:  Lung ultrasound (LUS) is a radiation-free tool used to diagnose pulmonary disease in the perioperative setting. Common diagnoses identified by LUS include pulmonary edema, atelectasis, pneumothorax and effusion. LUS has become a preferred alternative to CT in terms of accuracy and reliability and outperforms chest radiography in the critical care setting.

    Atelectasis is one of the most common complications in pediatric patients undergoing general anesthesia either with an endotracheal tube or laryngeal mask, with an incidence of 68 –100%. Atelectasis compromises gas exchange, worsens lung mechanics and increases the risk of lung inflammation. Usually the effect of atelectasis is self-limited in otherwise healthy pediatric patients but can hinder the recovery of pediatric cardiac surgery patients. Furthermore, this group of patients is at an even higher risk of atelectasis due to surgical manipulation and lung collapse during cardiopulmonary bypass (CPB). Lung recruitment maneuvers have been described in the adult cardiac surgery population but there is little evidence in the pediatric cardiac surgical population.

    In this single institution randomized control trial, the authors prospectively studied pediatric congenital heart disease (CHD) patients between the ages of 3 months to 3 years old scheduled for elective cardiac surgery with CPB under general anesthesia. Patients undergoing emergency surgery or who had a previous respiratory infection, pulmonary disease, genetic disorders, thoracic cage anomalies or abnormal lung imaging were excluded. The goals of the study were to: first, define the most useful lung region/s to diagnose atelectasis by LUS; second, compare the effects of pressure-controlled ventilation with and without low-level PEEP on lung aeration.

    Forty patients were randomly allocated to either a control or intervention group.  The control group was placed on 0 cm H2O PEEP while the intervention group was placed on 5 cm H2O PEEP just after intubation.  Both groups had a LUS examination performed by the same experienced anesthesiologist 1-minute and 15-minutes post-intubation following induction of general anesthesia. Six areas of the lung were examined bilaterally for a total of twelve scanned areas: anteriorly at clavicular midline region (scans 1 and 2), laterally at the middle axillary catheter region (scan 3), posteriorly at the posterior axillary line at the fifth, sixth, and seventh intercostal spaces (scans 4–6).  The ventilation management was the same pressure control ventilation (PCV) with a peak inspiratory pressure to achieve a tidal volume of 8–10 mL/kg and an end-tidal CO2 of 35–45 mm Hg. The frequency was set at a rate of 16–30 breaths/min depending on the patient’s age and the inspiratory: expiratory ratio of 1:2. Furthermore the intervention group was maintained on 5 cm H2O PEEP after intubation until the second LUS.

    The results were as predicted, with the most prevalent area for atelectasis being inferoposterior (Scans 4-6) with an incidence between 37.5 to 62.5%. Almost no atelectasis was visualized in the anterior and lateral regions of the lung. The addition of low-level PEEP of 5 cm H20 decreased the incidence of atelectasis in scans 4, 5, and 6 from 62.5% to 45% (p = 0.02), 60% to 27.5% (p = 0.002), and 35% to 20% (p = 0.035), respectively. No deleterious hemodynamic effects were seen with the level of PEEP used, but atelectasis persisted in a substantial group of patients (~30%). In addition. the authors calculated a lung aeration score and the atelectatic area. PCV with PEEP significantly reduced lung aeration scores from 13 (8.3-17.5) to 8 (3.3-9.8) and the atelectatic areas bilaterally from 128 mm2 (34.5–213.3 mm2) to 49.5 mm2 (5.3–75.5 mm2).

    Research shortcomings include being a single center study with a small sample size and having a single non-blinded anesthesiologist interpreting the images with its potential bias. The study population was not homogenous since it had wide age variation (3 month to 3 years), with the consequent size difference, and a mix of CHD (cyanotic and acyanotic). The intervention was brief (only 15 minutes of PEEP) leaving a substantial group of patients with persistent atelectasis (~30%). This poses the question whether higher levels of PEEP are necessary to completely eliminate atelectasis or if low-level PEEP for a longer period of time could resolve it.

    Interestingly the study opens up the question if LUS should become a standard of care in the pediatric cardiac operating room to allow early diagnosis of atelectasis. Ultimately, this demands further investigations to determine the optimal level of PEEP required to completely resolve atelectasis without causing hemodynamic compromise.

     

    Correlation Between ROTEM FIBTEM Maximum Clot Firmness and Fibrinogen Levels in Pediatric Cardiac Surgery Patients.

    Tirotta CF, Lagueruela RG, Madril D, Salyakina D, Wang W, Taylor T, Ojito J, Kubes K, Lim H, Hannan R, Burke R.

    Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029618816382. doi: 10.1177/1076029618816382. Epub 2018 Dec 5.

    PMID:  30518238

    Free PMC Article

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    Take Home Points:

     

    • Normal plasma fibrinogen levels as measured by the Clauss method are well defined for pediatric surgical populations, but measurement is not available for point-of-care (POC) testing.
    • The FIBTEM assay of rotational thromboelastometry (ROTEM) is a POC test that provides immediate results for transfusion guidance during pediatric cardiac surgery, but normal values in children have not been widely established.
    • Paired plasma fibrinogen and FIBTEM maximum clot firmness (MCF) levels were used to create an equation to predict plasma fibrinogen concentration for a given MCF, enabling application of POC ROTEM to immediate goal-directed transfusion.

     

     

    Commentary by Kelly A. Machovec, MD, MPH, Associate Professor of Anesthesiology at Duke University Medical Center:  Rotational thromboelastometry (ROTEM, Instrumentation Laboratory, Bedford, MA, USA) is a viscoelastic test used to monitor bleeding, coagulation and transfusion in the surgical or trauma setting.  The FIBTEM assay of ROTEM assesses the functionality and stability of fibrin polymerization.  The FIBTEM assay is conducted by tissue factor activation of the whole blood sample, followed by addition of cytochalasin D to inhibit the platelet contribution to clot strength, thus isolating the fibrin contribution.  POC ROTEM has been validated against laboratory ROTEM, but ROTEM FIBTEM values have not been validated against plasma fibrinogen concentration as measured by the Clauss method.  The authors of this study aimed to correlate MCF of the FIBTEM with plasma fibrinogen levels by the Clauss method in order to develop an equation to predict plasma fibrinogen levels from FIBTEM MCF results.

    This single center retrospective chart review examined consecutive patient charts over a 7-month period.  All charts of children 5 years old or less having cardiac surgery with peri-operative fibrinogen and FIBTEM values were included.  Time points of interest were prior to cardiopulmonary bypass (CPB) initiation, during CPB, and post-CPB separation.  Plasma fibrinogen levels were obtained in the laboratory using the Stago STA compact system, which uses a modified Clauss method to determine the fibrinogen concentration of a given blood sample.  The study team reviewed 50 charts, and found 27 patients who had a total of 87 incidences where FIBTEM MCF and plasma fibrinogen levels were obtained at the same time and could therefore be compared.

    Plasma fibrinogen levels and FIBTEM MCF values were found to be normally distributed by the Kolmogorov-Smirnov test.  Mean plasma fibrinogen was 178.1 mg/dl +/- 76.4.  Mean FIBTEM MCF was 8 mm +/- 4.3.  Linear regression of FIBTEM MCF and plasma fibrinogen showed a positive linear correlation.

    The authors then moved to the prediction equation.  First, simple linear regression was used to determine if FIBTEM MCF predicts plasma fibrinogen levels.  Then, this information was used to develop a regression equation to predict the plasma fibrinogen level given a FIBTEM MCF value.  Repeated 10-fold cross validation was used to develop, train and test the predictive equation.  The final model suggested the following equation can be used to predict plasma fibrinogen given FIBTEM MCF:

    Plasma fibrinogenmg/dl = 78.6 + 12.4 (MCFmm)

     

    The finding that plasma fibrinogen level correlates with FIBTEM MCF is consistent with other studies in both pediatric and adult patients.  This study, however, takes this relationship one step further by creating an equation to predict plasma fibrinogen from FIBTEM MCF.  This is clinically important because normal ROTEM values for pediatric populations are not clearly defined, which limits its utility as a POC assay.  In contrast, normal pediatric plasma fibrinogen levels are well defined, but are not readily obtained.

    The ability to rapidly translate FIBTEM MCF into a plasma fibrinogen level may aid the physician in interpreting this information and making prompt clinical decisions.  Importantly, because the FIBTEM amplitude at 5, 10, and 15 minutes after clotting time correlates with the final MCF, early FIBTEM POC values can be used to support a goal-directed transfusion practice. The authors provide the example of human fibrinogen concentrate: POC ROTEM can be used to estimate plasma fibrinogen level, which can then be used to calculate an accurate dose of human fibrinogen concentrate to raise plasma fibrinogen levels to the desired target level, rather than giving the standard 70 mg/kg dose.  One caveat that the authors acknowledge is that Factor XIII, at low levels in infants and children after CPB, affects FIBTEM results but has no effect on the plasma fibrinogen level as determined by Clauss method.

    The relationship between ROTEM FIBTEM and plasma fibrinogen level must be further explored, and the proposed predictive equation tested in a larger pediatric population.

     

     

     

    Near-infrared spectroscopy for prediction of extubation success after neonatal cardiac surgery.

    Gradidge EA, Grimaldi LM, Cashen K, Gowda KMN, Piggott KD, Wilhelm M, Costello JM, Mastropietro CW.

    Cardiol Young. 2019 Jun;29(6):787-792. doi: 10.1017/S1047951119000829. Epub 2019 Jun 6.

    PMID:  1169104

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    Take Home Points:

     

    • Extubation failure after neonatal cardiac surgery is high, with more than 1 out of 10 neonates failing extubation. While there is consensus in the literature on the criteria for the need for mechanical ventilation in the critically ill neonate, there is no consensus on the criteria for weaning from mechanical ventilation and extubation readiness of neonates.
    • A secondary analysis on previously collected multi-center prospective observational data in neonates after cardiac surgery evaluated NIRS as a parameter to predict extubation success. An increase in cerebral NIRS of ≥ 5% from baseline at the time of extubation was 98% predictive of extubation success. However, this change was present in only half of the neonates successfully extubated, indicating a low negative predictive value. Changes in renal regional oximetry were not prognostic of extubation outcome.

     

    Commentary from Olga Pawelek, M.D. and Nischal Gautam, M.D., pediatric cardiac anesthesiologists at the McGovern Medical School/ Children’s Memorial Hermann, Houston, Texas:  Over the past decade, great strides have been made in the perioperative care of neonates undergoing cardiac surgery to decrease mortality2. Despite this success, failure to extubate after neonatal cardiac surgery remains a significant complication and is reported anywhere between 6-21%3. Extubation failure and prolonged mechanical ventilation impact hospital length of stay and are associated with increased morbidity and mortality. Both modifiable and non-modifiable risk factors, such as hypoxic insults from birth or during surgery, genetic abnormalities, age, weight, and anatomic variants, heavily influence postoperative outcomes such as extubation success and the need for prolonged intensive care 2. These factors along with the high extubation failure rate after neonatal cardiac surgery suggest that a prognostic factor is needed to help determine the timing or readiness for tracheal extubation. Various measures, including neuromuscular function, oxygenation, and ventilation indices, have been examined as potential extubation readiness tools, however they have not been proven reliable.

     

    Gradidge et al.’s results stem from a secondary analysis of prospectively collected cross-sectional data on neonates who underwent cardiac surgery at seven US tertiary children’s hospitals over one year (2015). Baseline or pre-incision cerebral and renal oximetry values using the INVOS oximeter probes were compared to another set in the intensive care unit at a time closest to extubation. Since the analysis was observational, there was not a consistent extubation protocol. Extubation failure was defined as a need for unplanned reintubation within 72 hours of planned extubation.

     

    In this cohort of 159 patients, extubation failure after neonatal cardiac surgery was reported at 9.4%, which is similar to other studies 4. Baseline oximetry values and patient characteristics such as age, weight, duration of cardiopulmonary bypass and cross-clamp times had no impact on extubation outcomes. At the time of extubation, both cerebral and renal oximetry values were higher than baseline in patients extubated successfully and lower than baseline in patients who failed extubation.  An increase in cerebral NIRS of ≥ 5% from baseline at the time of extubation was found to be predictive of extubation success. While this was 92% specific, with a 98% positive predictive value of extubation success, it was only 50% sensitive.  After adjusting for variables, this ≥5% change was independently associated with extubation success (odds ratio of 10.9).  By contrast, an increase in renal NIRS was a poor predictor of extubation success.

     

    What does this mean for us?

    Staged weaning from mechanical ventilation consists of measuring the potential cushion in the cardiopulmonary reserves to accommodate for the increased oxygen consumption from the work of spontaneous ventilation. In neonates tottering on the margins of critical oxygen delivery when oxygen extraction is at its maximum, especially in the heavily auto-regulated areas of the brain, it is not unusual for the mixed venous oxygen saturation to be lower at the time of extubation. Once the noxious stimulus of the endotracheal tube is removed and considering adequate pain control, it should be expected that the oxygen consumption and extraction decrease and the oxygen supply/consumption ratio is restored above anaerobic or critical levels. Given these assumptions, should a change in regional oximetry from baseline at the time of extubation be predictive of extubation success? The authors confirm that extubation failure after cardiac surgery is indeed high, and that 1 in 10 neonates will fail extubation after cardiac surgery. One of the significant takeaways from Gradidge et al. study is that there potentially exists a feel-good factor for extubation success when a ≥ 5% positive change in cerebral oximetry is observed at the time of extubation. This positive change metric was 98% predictive in determining extubation success. This high level of specificity could add another parameter to the checklist for extubation readiness.

     

    However, some major limitations need to be addressed before we consider this metric as a tool for extubation. In this study, more than 50% of the neonates were extubated successfully even when this magnitude of change in oximetry was not present.  Why did the metric fail to predict extubation in these patients?  Similarly, why was the negative predictive value low for this metric? There could be many reasons for these observations. The data analysis was based on a prospective observational study and had many limitations based on the accuracy of the NIRS technology, especially during states of agitation and wakefulness.  The secondary analysis was not adequately powered for this outcome.  The retrospective nature of the study could have led to convenience-based sampling bias. There was no standardized extubation protocol or a re-intubation protocol across the seven centers. This lack of standardization of the weaning process could lead to significant differences in patient management across the centers and therefore result in variable outcomes. Lastly, the authors compare baseline values, when neonates were intubated, deeply sedated, well-oxygenated/ventilated, to values at the time of extubation, when neonates were nearly awake or agitated. In the postoperative period after neonatal cardiac surgery, the cerebral metabolic oxygen consumption rate is increased and can last many days. It is possible that the brain auto-regulates by increasing cerebral oxygen extraction, therefore expected increases in cerebral regional oximetry may not occur even if corrective surgeries increase systemic oxygen saturation. To validate this, a recently published prospective observational study5 analyzed oximetry changes after the correction of cyanotic congenital heart disease. Wong et al., observed that although the systemic oxygen saturation increased significantly to near normal values after correction of cyanotic heart disease, the cerebral and renal oximetry values did not increase but rather decreased compared to baseline at the time of discharge.

     

    In conclusion, cerebral NIRS monitoring and change from baseline may be predictive of extubation success and used as one of the factors during assessment of neonates’ readiness to extubate. Future prospective trials powered to study the impact of regional oximetry as a tool for extubation readiness should be encouraged.

     

     

    References:

     

    1. Gradidge EA, Grimaldi LM, Cashen K, Gowda KMN, Piggott KD, Wilhelm M, Costello JM, Mastropietro CW: Near-infrared spectroscopy for prediction of extubation success after neonatal cardiac surgery. Cardiology in the young 2019; 29:787–92
    2. Blinder JJ, Thiagarajan R, Williams K, Nathan M, Mayer J, Kulik TJ: Duration of Mechanical Ventilation and Perioperative Care Quality After Neonatal Cardiac Operations. Ann Thorac Surg 2017; 103:1956–62
    3. Miura S, Hamamoto N, Osaki M, Nakano S, Miyakoshi C: Extubation Failure in Neonates After Cardiac Surgery: Prevalence, Etiology, and Risk Factors. Ann Thorac Surg 2017; 103:1293–8
    4. Mastropietro CW, Cashen K, Grimaldi LM, Narayana Gowda KM, Piggott KD, Wilhelm M, Gradidge E, Moser EAS, Benneyworth BD, Costello JM: Extubation Failure after Neonatal Cardiac Surgery: A Multicenter Analysis. J Pediatr 2017; 182:190–4
    5. Wong JJ-M, Chen CK, Moorakonda RB, Wijeweera O, Tan TYS, Nakao M, Allen JC, Loh TF, Lee JH: Changes in Near-Infrared Spectroscopy After Congenital Cyanotic Heart Surgery. Front Pediatr 2018; 6:97

     

    Anesthesia critical care Nov 2019

    1. Neonatal Anesthesia.

    Boyer TJ, Kritzmire SM.

    StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.

    2019 Nov 10.

    PMID: 31082074 Free Books & Documents

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    1. Anesthesia Practice: Review of Perioperative Management of H-Type Tracheoesophageal Fistula.

    Edelman B, Selvaraj BJ, Joshi M, Patil U, Yarmush J.

    Anesthesiol Res Pract. 2019 Nov 3;2019:8621801. doi: 10.1155/2019/8621801. eCollection 2019. Review.

    PMID: 31781201 Free PMC Article

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    1. Extubation on the operating table in patients with right ventricular pressure overload undergoing biventricular repair†.

    Nawrocki P, Wisniewski K, Schmidt C, Bruenen A, Debus V, Malec E, Januszewska K.

    Eur J Cardiothorac Surg. 2019 Nov 1;56(5):904-910. doi: 10.1093/ejcts/ezz139.

    PMID: 31323661

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    The CHIP Network Journal Watch Team

    Konstantin Averin, MD, MS is an Associate Professor of Pediatrics at the University of Alberta and an Interventional Pediatric Cardiologist at the Stollery Children’s Hospital in Edmonton, Alberta. He received his medical degree from the Feinberg School of Medicine at Northwestern University in Chicago, IL. After medical school, he completed pediatrics residency, pediatric cardiology fellowship and sub-specialty training in pediatric and adult interventional cardiology at the Cincinnati Children’s Hospital in Cincinnati, OH. His clinical and research interests are focused on the percutaneous treatment of pediatric patients with congenital and acquired heart disease with a focus on patients with single ventricle physiology, transcatheter pulmonary valves, and pulmonary hypertension.

    Dr. Leong Ming Chern “MC” is an adult congenital heart disease specialist at the National Heart Institute, Kuala Lumpur, Malaysia. He received his medical training at the University of Malaya and pediatric cardiology training at the National Heart Institute. His area of interest includes treatment of adult patients with congenital heart disease and pulmonary hypertension in congenital heart disease.

    Dr. Damien Cullington, MBChB MRCP MD FESC is a consultant adult congenital cardiologist who works at Leeds General Infirmary, UK. In summer 2019, he will move over to the newly commissioned North West ACHD Service based in Liverpool, UK. Damien qualified in 2002 from the University of Liverpool and became a substantive consultant in 2016. Prior to this, he worked throughout the North of England and Yorkshire as a cardiology trainee. Damien was awarded a doctorate in medicine (MD) from the University of Hull in 2013 for his work in heart rate in patients with heart failure. He is a member of the Royal College of Physicians (London), Fellow of the European Society of Cardiology and honorary senior lecturer for the University of Leeds. His ACHD subspecialty clinical interests are heart failure, imaging and palliative care. He is regional organiser for ACHD training at Leeds and clinical governance lead for the Leeds congenital cardiac unit. His research interests and wide and far but particularly epidemiology, chronic heart failure in ACHD patients in all its guises, the systemic RV and the univentricle

    Dr. Blanche Cupido is a consultant adult cardiologist working at Groote Schuur Hospital, UCT Private Academic Hospital and the University of Cape Town(UCT), South Africa. She completed her physician training in 2009 and her cardiology subspecialist training in 2013. She recently returned to SA after doing a Fellowship in Adult Congenital Heart Disease in Leeds, United Kingdom under the guidance of Dr Kate English. She has established a dedicated unit for Grown Up Congenital Heart Disease in Cape Town, South Africa. Her aim is to grow ACHD services in Sub-Saharan Africa and embark on GUCH research on the African continent.

    Dr. Jeremy L. Herrmann is an Assistant Professor of Surgery in the Division of Thoracic and Cardiovascular Surgery at Indiana University. He specializes in pediatric and adult congenital cardiac surgery, and his clinical interests also include heart transplantation and mechanical circulatory support. His hospital affiliations include Indiana University Health Riley Hospital for Children and Methodist Hospital as well as Peyton Manning Children’s Hospital at St. Vincent Hospital in Indianapolis

    Maan Jokhadar is a cardiologist and associate professor of medicine at Emory University in Atlanta, Georgia. He is board certified in internal medicine, cardiovascular disease, advanced heart failure/transplantation, adult congenital heart disease, and echocardiography. He is fellowship director for the Emory Adult Congenital Heart Disease training program and Core Curriculum Director for the Emory general cardiology fellowship program. Dr Jokhadar graduated from the University Damascus School of Medicine in Syria and then went to Mayo Clinic in Rochester, Minnesota for internal medicine residency. He then completed cardiology and subspecialty training at Emory University, where he currently on faculty. Dr. Jokhadar has been the recipient of numerous teaching awards. He is married with 3 children.

    Michael Ma, MD is an Assistant Professor in Cardiothoracic Surgery in the Division of Pediatric Cardiac Surgery at Stanford University. He specializes in pediatric and adult congenital cardiac surgery, with an emphasis on neonates, complex biventricular repair, and pulmonary artery reconstruction. His research lab investigates ex and in vivo translational models for complex congenital heart disease, to optimize future surgical and endovascular repair strategies.

    Jeremy P. Moore MD MS FHRS is the Director of Clinical Research and faculty in Pediatric Cardiology and Adult Congenital Heart Disease at the University of California, Los Angeles. Dr. Moore received his medical degree from the Medical College of Virginia in 2003. He completed residency and fellowship at UCLA before pursuing his subspecialty training in Pediatric Electrophysiology at Vanderbilt University in 2009. Dr. Moore has been faculty at UCLA since 2010 and has since published numerous research manuscripts dealing with electrophysiologic aspects pertinent to congenital heart disease. Dr. Moore’s primary interest is the study of mechanisms of arrhythmia, and the development of novel electrophysiologic techniques for management of the adult patient with congenital heart disease

    Dr. Mehul Patel MD, is a structural and adult congenital heart disease specialist and an interventional cardiologist. Dr. Patel earned his undergraduate and medical education from the Mumbai University, India. After completing his post-graduate training in Internal Medicine and Cardiology, he further trained in interventional cardiology at the Mount Sinai Medical Center, NYC, NY and Adult Congenital Heart Disease at the Texas Children’s Hospital, Texas Heart Institute, Baylor College of Medicine, Houston, TX. Dr. Patel worked as Chief of adult congenital heart disease, Assistant Professor at the Michigan State University, Grand Rapids, MI where he not only expanded the program, performing complex interventions and device implantations but also established the percutaneous pulmonary valve implantation (Melody Valve) Program. Due to his passion for treating structurally abnormal hearts, he did a dedicated year of Structural Heart Disease fellowship at Henry Ford Hospital, Detroit, MI where he worked with pioneers in this field before moving to North Carolina. He is proficient in performing transcatheter aortic valve replacement (TAVR), MitraClip, Watchman device implantation, percutaneous Mitral, Tricuspid and Pulmonary valve replacements along with a variety of interventions on congenital heart disease and pulmonary hypertension. Dr. Patel is ABIM board certified in Internal Medicine, Cardiology, Interventional cardiology and Adult Congenital Heart Disease. Dr. Patel has more than 50 peer reviewed publications and numerous abstracts to his credit. He serves as a Co-Editor-in-Chief for the CHiP Network journal watch. His wife, Khyati is a pediatric cardiac Electrophysiologist and they have a 9-year-old daughter. Dr. Patel is also an artist, likes music, yoga and plays badminton. His clinical areas of expertise and interests are: 1) Transcatheter therapies for Structural and Adult Congenital heart disease. 2) Complex device implantations.

    Dr. Timothy Pirolli is an Assistant Professor of Surgery in the Division of Pediatric Cardiothoracic Surgery at University of Texas Southwestern Medical Center. He specializes in pediatric and adult congenital cardiac surgery. His hospital affiliations include Children’s Medical Center in Dallas, Parkland Memorial Hospital, and Clements University Hospital (UTSW).

    Dr. Inga Voges, M.D. Consultant in Pediatric Cardiology, Lead Consultant Cardiovascular MRI. I trained in General Pediatrics and Pediatric Cardiology in Rostock (Germany) and Kiel (Germany) from 2002-2010 and did additional training in Adult Congenital Heart Disease (ACHD) in Kiel (Germany) which I finished in 2014. I specialized in Cardiovascular Magnetic Resonance Imaging (CMR) and have a further special interest in cardiomyopathies. Currently, I am working as a consultant pediatric and ACHD cardiologist at the University Hospital Schleswig-Holstein (Kiel, Germany) where I am responsible for the CMR imaging program in pediatric and ACHD patients and contribute to the care of patients with acquired and congenital heart disease. I received my MD from the Medical University Luebeck in 2006 (Germany) and finished my “Habilitation” (PhD equivalent; University Hospital Kiel, Germany) in 2014. Since 2016, I am the secretary of the Association for European Paediatric and Congenital Cardiology Imaging Working Group.

    Dr. Gary Webb, M.D. is an Emeritus Professor of Pediatrics and Internal Medicine at the University of Cincinnati College of Medicine and,
    from 2009-2016, the Director of the Adult Congenital Heart Program at Cincinnati Children’s Hospital Heart Institute. A graduate of McGill
    University in Montréal, he interned at the Royal Victoria Hospital, and then trained in internal medicine and cardiology at the University of Toronto. From 1980-2004, he was co-director and then director of the Toronto Congenital Cardiac Center for Adults at Toronto General Hospital. He is a Fellow of the Royal College of Physicians and Surgeons of Canada in both internal medicine and cardiology. From 2004-2009, he was director of the Philadelphia Adult Congenital Heart Center at the University of Pennsylvania. Since 2016, he has been a consultant to Cincinnati Children’s Hospital, and has been responsible for the ACHD Learning Center, the Cardiology Fellow Testing Center, and the Congenital Heart Professionals International (CHIP) Network. Since 2017, he has resumed seeing patients on a part-time basis at the Toronto Congenital Cardiac Centre for Adults.

    Wendy Whiteside, MD Wendy is Assistant Professor of Pediatrics and Associate Director of Interventional Pediatric Cardiology at the University of Michigan Congenital Heart Center, C.S. Mott Children’s Hospital. She obtained her medical degree from Albert Einstein College of Medicine in 2006 then completed pediatric residency at Children’s Hospital Oakland in Oakland, CA in 2009. She received
    both her categorical and interventional pediatric cardiology training at the University of Michigan in Ann Arbor, MI. Her clinical and research interests include single ventricle physiology, transcatheter
    pulmonary valves, and quality improvement within the cardiac catheterization laboratory.

    About the Congenital Heart and Pediatric Cardiac Journal Watch

    Congenital heart and pediatric cardiac Journal Watch was designed to make it easier for congenital heart and pediatric cardiac professionals to keep up with the literature in 6 subsections of congenital heart disease abstracts on a monthly basis: pediatric cardiology; congenital heart surgery; congenital  heart interventions; congenital/pediatric electrophysiology; fetal cardiology; and adult congenital heart disease.

    We encourage your continued support as well as your valuable comments and feedback.

    Learn More

    Sincerely,

    Dr. Gary Webb, MD and Dr. Mehul Patel
    CHiP Network
    Congenital Heart and Pediatic Cardiac Journal Watch Editorial Board

    The Chip Network, the Congenital Heart International Professionals Network, aims to develop a single global list of all congenital and pediatric cardiac professionals.

    We invite you to share this with your colleagues.