CHiP Network Congenital Heart Journal Watch – November 2019

Pediatric Cardiology Featured Articles

Pediatric Cardiology Reviews of September 2019 Manuscripts

 

Pediatric Cardiology Reviews of September 2019 Manuscripts

2-Year Outcomes After Complete or Staged Procedure for Tetralogy of Fallot in Neonates.

Savla JJ, Faerber JA, Huang YV, Zaoutis T, Goldmuntz E, Kawut SM, Mercer-Rosa L.

J Am Coll Cardiol. 2019 Sep 24;74(12):1570-1579. doi: 10.1016/j.jacc.2019.05.057.

PMID: 31537267

Take-Home Points: 

  • Complete repair has a higher mortality than a staged approach in neonates with tetralogy.
  • Postoperative cardiac complications are the most likely mediator for this relationship.

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch:  Symptomatic/cyanotic infants with TOF require neonatal intervention. There has been debate as to the better strategy: palliation with a shunt or complete repair. Both have advantages and disadvantages. Shunt palliation will prolong cyanosis and require a 2nd surgery.  However, complete repair is a more complex procedure with a longer hospital course and less patients would be able to have a valve-sparing repair, which likely has much better long term consequences. It is known that neonatal repair has a higher morbidity and mortality than later complete repair, but it has not yet been clear which approach may result in the best outcomes in the neonatal population.

This was a retrospective cohort study using the Pediatric Health Information System (PHIS) database between 2004-2015. Primary outcome was death during the 2 year follow up after initial procedure. Somewhat complex statistics were necessary to control for patient and hospital based characteristics, as both could influence the choice of surgical approach. An inverse probability weighted Cox model was used to estimate the effect of the initial procedure on late mortality and a logistic regression was used to analyze mortality within the first hospitalization. To address unmeasured confounding variables and their relative strength, E values were calculated for the estimated hazard and odds ratios.

2363 patients were studied; 1032 had a complete repair and 1331 were staged. Table 1 showed good balance in the weighted sample, with no demographic or patient characteristics being significantly different (all < 10%). Surgeries were performed at 45 hospitals; 24% performed greater than ⅔ complete repairs, 33% performed greater than ⅔ staged repairs, and 42% had equal proportions. Median length of initial hospital stay was 16 days for the complete repair and 15 days for the staged repair. There were 239 deaths, 92 in the complete and 147 in the staged groups. Figure 1 shows the breakdown of each cohort. Complete repair had a greater risk for mortality within the 2 year follow up (HR 1.51) and is shown graphically below. There was no difference within the first week, but from day 7-30 (early), the complete group had an increased risk of mortality (HR 2.29). E-value calculations indicated that only the presence of very strong unmeasured confounders could explain the association of type of repair and survival. See Table 2.  At least one in-hospital cardiac complication was observed in 36.1% of the complete group and 15.4% of the staged group. This was shown to be the primary mediator between surgical approach and mortality, with 87% of the total effect attributable to early mortality and 80% to late mortality. Non-cardiac complications did not mediate the treatment-mortality relationship. However, subgroup analysis did not show a difference in mortality for patients who received a BT shunt versus complete repairs, nor were there differences in those that received an RV to PA conduit within the complete repair group. The authors write that the trend was similar for benefit of BT shunt over complete repair, but the study was possibly underpowered to detect a significant relationship.

As an accompanying editorial suggests, given the limitation of an administrative dataset, the most likely influence of this study will be on those considered to be higher risk. If there is a way to identify those that are more likely to have a cardiac complication, or a way to prevent that complication from occurring, then complete repair risk may be mitigated. Additionally, of those patients in the staged group that did not receive a BT shunt, was it improved catheter based therapy such as RVOT stenting or PDA stenting that led to the improved mortality? Overall, it does seem that a less-invasive initial approach should be favored, especially in the highest risk patients, and decision-making should be individualized to achieve the best possible results. A risk-stratification model may be the next logical step to help determine who may benefit the most from a given therapy.

 

 

Pharmacologic stress cardiovascular magnetic resonance in the pediatric population: A review of the literature, proposed protocol, and two examples in patients with Kawasaki disease.

Fares M, Critser PJ, Arruda MJ, Wilhelm CM, Rattan MS, Lang SM, Alsaied T.

Congenit Heart Dis. 2019 Sep 9. doi: 10.1111/chd.12840. [Epub ahead of print] Review.

PMID: 31498562

 

Take-Home Points: 

  • Pharmacologic stress cardiovascular MRI (PSCMR) is an underused but potentially very helpful modality in assessing certain types of pediatric CHD, especially those with coronary abnormalities or coronary reimplantation.
  • Further focused research as well as cost-analysis may be useful, but integrating this with a larger stress perfusion testing center may be most effective.

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch:  A large trial recently published in JACC on MRI stress perfusion in adults with coronary artery disease received a lot of attention due to the high sensitivity and cost-effectiveness of what is a clearly underused and under-available modality. This was a review article on its use in the pediatric/adult congenital population along with proposed protocols.  Exercise stress testing is of course not feasible for all patients, but the sensitivity and specificity may be low, especially when trying to assess perfusion of the right ventricle. This is also a known limitation of nuclear testing. Often times, pediatric cardiologists need to make decisions based on echo findings, standard stress testing, or sometimes resort to an invasive cardiac catheterization, but which still do not always provide the prognostic information necessary to decide whether surgery or other management needs to occur.

Table 1 lists high risk cohorts who could theoretically benefit from PSCMR which can be categorized as surgical coronary reimplantation, anomalous coronary artery (AAOCA), acquired disease (such as Kawasaki disease (KD)), or systemic right ventricle. Inotropic agents (dobutamine) and coronary vasodilator agents can be used to mimic physical exercise. Dobutamine may be better utilized when there is concern for dynamic obstruction such as in AAOCA or myocardial bridging. A newer vasodilating agent, Regandenoson, has a better side effect profile and only requires a single bolus instead of a continuous infusion as needed in older agents (adenosine/dipyridamole). The authors list the few, relatively small, studies done using PSCMR, and highlight the fact that there is data to suggest higher sensitivity and specificity, along with the advantages of no radiation exposure and not being limited by acoustic windows (as stress echo may be). They also provide a suggested protocol along with dosage when using dobutamine, adenosine, and regadenoson and provide a conceptual framework for imaging (Figure 1). Finally, they discuss 2 case reports of patients with KD and the clear utility of PSCMR. The first case was a patient with a history of giant aneurysms that had mostly resolved and with a normal treadmill stress test. PSCMR showed perfusion defects, and the patient ultimately underwent cutting balloon dilation. The 2nd case was a young patient (4 years old), too young to undergo standard stress testing, with giant aneurysms and perfusion defects. A cath showed near occlusion of the LAD and he underwent CABG.

Hopefully, there will be further published studies looking at PSCMR in pediatric patients, as this is a modality that can be very helpful in certain subgroups for which current testing is limited.

 

 

Necrotizing Enterocolitis and Associated Mortality in Neonates With Congenital Heart Disease: A Multi-Institutional Study.

Spinner JA, Morris SA, Nandi D, Costarino AT, Marino BS, Rossano JW, Shamszad P.

Pediatr Crit Care Med. 2019 Sep 20. doi: 10.1097/PCC.0000000000002133. [Epub ahead of print]

PMID: 31568264

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Take-Home Points:

  • The prevalence of NEC in neonates with congenital heart disease is 3.7 %.
  • Hypoplastic Left Heart Syndrome and TA were the two cardiac lesions associated with the highest frequency of NEC. The odds of developing NEC were 2.7 and 2.6 times when compared to the lesion with the lowest incidence of NEC, that is Transposition of great arteries.
  • Adjusted risk factors associated with the development of NEC included prematurity, male sex, AA race, GI abnormality, and additional birth defects. 
  • The overall hospital mortality of neonates with CHD and NEC was significantly higher than compared to neonates with CHD  and no NEC.
  • NEC was also associated with increased total hospital charges, longer ICU LOS and hospital LOS when compared to those without NEC and the association remained significant when analyzed by the individual cardiac defect.
  • No association was found with a 30-day readmission rate.

 

Commentary from Dr. Venugopal Amula (Salt Lake City, UT), section editor of Pediatric Cardiology Journal Watch:  This is a retrospective multi-institutional study describing the prevalence and mortality of necrotizing enterocolitis (NEC) in neonates with congenital heart disease. The Pediatric Health Information System database was queried for all index hospitalizations involving neonates with CHD between 2004 to 2015 and the primary outcome was the presence of NEC during the index hospitalization. Secondary outcomes studied included in-hospital mortality, hospital LOS, ICU LOS, hospital charges and 30-day readmission. Multivariable analysis for the presence of NEC and in-hospital mortality were performed for each heart defect category utilizing generalized estimating equations to adjust for hospital clustering. The heart defect categories included Single ventricle, Tricuspid atresia (TA), Truncus arteriosus, Transposition of great arteries, Tetralogy of Fallot and isolated arch obstruction. Variables included in the multivariable model for the presence of NEC were prematurity, African American race, male sex, additional birth defect or GI anomaly.

 

 

 

 

2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT.

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D’Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh RMR, Warnecke G, Wåhlander H, Weber SC, Zartner P.

J Heart Lung Transplant. 2019 Sep;38(9):879-901. doi: 10.1016/j.healun.2019.06.022. Epub 2019 Jun 21.

PMID: 31495407

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Take-Home Points:

  • Based on the World Symposium of Pulmonary Hypertension WSPH ( Nice, 2018) PH is now defined as mean Pulmonary Artery Pressure (mPAP) > 20mm in children > 3 months of age at sea level. The limit was decreased from 24 to 20mm hg based on adult studies where even mild elevation of mPAP between 20-24mm Hg was found to be independent predictor of poor survival.
  • Children with suspected PH should be evaluated, treated and monitored in specialized pediatric centers. The initial evaluation should include a comprehensive medical history, physical examination, assignment to the functional class, assessment of cardiac function by ECG, Echocardiogram. Further testing and advance imaging is guided by the key findings in the history and include but are not limited to cardiac catheterization, HR-Chest CT with angiography, V/Q scan, Sleep study, Blood gas analysis, Lung function test, etc.
  • Some determinants of higher risk in pediatric PH include clinical evidence of RV failure, progressive symptoms, presence of syncope, growth failure, severely elevated Serum NT-proBNP (> 1200 pg/ml (>1 yr. old).
  • Transthoracic Echocardiogram (TTE) cannot establish a definite diagnosis of PH or determine WHO PH group. PH diagnosed by TTE should be confirmed by catheterization before initiation of targeted PH therapy except in infants with PPHN, BPD and those with high risk. We should rely on a multiparametric approach other than single parameters. Echo or CMR variables that are determinants of high risk include evidence of severe RA/RV enlargement, RV systolic dysfunction, RV/LV end systolic ratio of >1.5, TAPSE ¯¯ (Z-score , -3). Systolic/Diastolic ratio > 1.4 (TR jet ), Pulmonary Artery Acceleration Time PAAT < 70ms and  Pericardial effusion.

 Cardiac catheterization is indicated in all pediatric patients with PH to confirm a diagnosis and determine severity, especially when considering pharmacotherapy except in infants and Low body weight or those presenting critically ill where it can be omitted until more stable. The cardiac catheterization should include Acute Vasoreactivity testing. In children with IPAH/HPAH, the hemodynamic change that defines a positive response to AVT in PH without CV shunt is > 20% fall in mPAP and PVR/SVR ratio without a decrease in CI. Invasive hemodynamics that portend high risk include Cardiac Index < 2.5. mRAP> 15, mPAP/mSAP> 0.75, PVRi> 15 Wu-m

  • In centers equipped to perform advanced pediatric cardiac magnetic resonance imaging, CMR without anesthesia /sedation is recommended as a part of diagnostic evaluation and follow up to assess changes in ventricular function and chamber dimensions.
  • Several Pulmonary Arterial Hypertension (PAH) associated genes have been identified and genetic testing can allow the definition of PAH etiology, estimation of prognosis and identification of families at risk. Hence genetic counseling by trained personnel before genetic testing is recommended for families with children diagnosed with Idiopathic PAH or Heritable PAH. Children who are asymptomatic PAH mutation carriers, asymptomatic first-degree relatives of patients with HPAH without an associated gene mutation should be screened by serial echocardiograms every 1-3 yrs. for the presence of elevated RV pressure and undergo additional diagnostic evaluation if clinically indicated.
  • In patients with PAH associated with congenital heart disease a complete diagnostic workup should be performed to determine whether PAH is associated with or causally related to concomitant CHD. Children with simple shunt defects beyond the typical timing of surgery (> 6 months old ) and with severe cyanosis should undergo comprehensive right and left heart catheterization before any intervention or surgery. Standard management is adopted for PVR1< 6 Wu-m2 and PVR/SVR < 0.3. For patients in gray zone PVRi 6-8 Wu -m2 – a treat and repair approach is reasonable using PAH targeted pharmacotherapy with 1-2 medications. A shunt defect must not be closed in when PVRi > 8 Wu- m2 in children.
  • The term and preterm newborn infant with PPHN should receive oxygen, ventilatory support, surfactant with a goal preductal sat of 91-95 %. Inhaled Nitric Oxide is indicated to improve oxygenation and to reduce the need for ECMO if PaO2 < 100 on 100% oxygen or OI index > 25. In the presence of right heart failure preterm and term infants with PPHN should receive PGE infusion to maintain ductal patency in the absence of post tricuspid unrestrictive shunt.
  • In the pediatric ICU, oxygen is administered when the SaO2 < 95% in children with PH and normal anatomy. iNO may be considered for postoperative PH treatment in mechanically ventilated patients to improve oxygenation and reduce PHT crises. Concomitant sildenafil should be administered to prevent rebound PH while weaning iNO. Inhaled iloprost can be as effective as iNO in children with postoperative PH.
  • The diagnosis and management of PH in middle and low-income regions should be done with specialized centers and endemic diseases should be considered in etiology. Schistosomiasis, Rheumatic heart disease, HIV infection, high altitude, chronic hepatitis, etc. should be considered. Treatment should be based on individual case assessment and PAH targeted medications may help especially when pursued at centers specialized in PH.
  • Treatment of PH should be under expert guidance. Supportive therapy with oxygen, Diuretic therapy, anticoagulation should be based on a specific type of PH, CCB should be considered in those patients who are acutely reactive to iNO with or without oxygen. They should be avoided in AVT nonresponders and children with right heart failure regardless of AVT response.

Commentary from Dr. Venugopal Amula (Salt Lake City, UT), section editor of Pediatric Cardiology Journal Watch:  To provide a specific, comprehensive, detailed and practical framework for the clinical care of children and young adults with Pulmonary Hypertension, the European Pediatric Pulmonary Vascular Disease Network constituted an executive writing group. The executive writing group members conducted a thorough scientific review and generated tables with graded recommendations based on the European Society of Cardiology/ American Heart Association definitions. They included studies with pediatric data only,  adult studies that included> 10% of children or studies that enrolled adults with CHD. Although the majority of recommendations on pediatric PH are based on the level of evidence B or C,  much effort has been made to obtain pediatric data from registries and clinical studies. A summary of such recommendations is provided below.

Updated Clinical Classification of Pulmonary Hypertension, WSPH, Nice, 2018

 

Diagnostic algorithm for a child or young adult with suspected pulmonary hypertension

 

 

Algorithm for management of patients with CHD associated with PAH/Pulmonary Hypertensive Vascular Disease and congenital shunt lesions.

 

 Treatment algorithm for Pediatric PAH

 

 

Pediatric cardiology Sept 2019

  1. Atrial septal defects, supravalvular aortic stenosis and syndromes predisposing to aneurysm of large vessels.

Baglivo M, Dassati S, Krasi G, Fanelli F, Kurti D, Bonelli A, Arabia G, Fabbicatore D, Muneretto C, Bertelli M.

Acta Biomed. 2019 Sep 30;90(10-S):53-57. doi: 10.23750/abm.v90i10-S.8760.

PMID: 31577255

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  1. Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3.

Kühnisch J, Herbst C, Al-Wakeel-Marquard N, Dartsch J, Holtgrewe M, Baban A, Mearini G, Hardt J, Kolokotronis K, Gerull B, Carrier L, Beule D, Schubert S, Messroghli D, Degener F, Berger F, Klaassen S.

Clin Genet. 2019 Sep 30. doi: 10.1111/cge.13645. [Epub ahead of print]

PMID: 31568572

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  1. A de novo splicing variant supports the candidacy of TLL1 in ASD pathogenesis.

Alanzi T, Alhashem A, Dagriri K, Alzahrani F, Alkuraya FS.

Eur J Hum Genet. 2019 Sep 30. doi: 10.1038/s41431-019-0524-0. [Epub ahead of print]

PMID: 31570783

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  1. Behaviour and emotions of children and young people with congenital heart disease: A literature review.

Dahlawi N, Milnes LJ, Swallow V.

J Child Health Care. 2019 Sep 30:1367493519878550. doi: 10.1177/1367493519878550. [Epub ahead of print]

PMID: 31569967

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  1. Small 7p22.3 microdeletion: Case report of Snx8 haploinsufficiency and neurological findings.

Mastromoro G, Capalbo A, Guido CA, Torres B, Fabbretti M, Traversa A, Giancotti A, Ventriglia F, Bernardini L, Spalice A, Pizzuti A.

Eur J Med Genet. 2019 Sep 27:103772. doi: 10.1016/j.ejmg.2019.103772. [Epub ahead of print]

PMID: 31568860

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  1. Recommendations from the Association for European Paediatric and Congenital Cardiology for training in pulmonary hypertension.

Sallmon H, Moledina S, Albert DC, Beghetti M, Berger RMF, Bonnet D, Bukova M, Koestenberger M, Meinel K, Reinhardt Z, Tulloh RMR, de Wolf D, Hansmann G.

Cardiol Young. 2019 Sep 26:1-5. doi: 10.1017/S104795111900235X. [Epub ahead of print]

PMID: 31554525

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  1. Left superior pulmonary artery sling.

Wang G, Zhou G.

J Card Surg. 2019 Sep 26. doi: 10.1111/jocs.14268. [Epub ahead of print]

PMID: 31557345

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  1. Cohort and Individual Neurodevelopmental Stability between 1 and 6 Years of Age in Children with Congenital Heart Disease.

Naef N, Wehrle F, Rousson V, Latal B.

J Pediatr. 2019 Sep 25. pii: S0022-3476(19)31094-7. doi: 10.1016/j.jpeds.2019.08.036. [Epub ahead of print]

PMID: 31563274

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  1. Neonatal Tetralogy Staged Versus Complete Repair: Is it Time to Rethink Neonatal Tetralogy?

Van Arsdell GS, Levi DS.

J Am Coll Cardiol. 2019 Sep 24;74(12):1580-1581. doi: 10.1016/j.jacc.2019.06.031. No abstract available.

PMID: 31537268

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  1. Human Milk Use in the Preoperative Period Is Associated with a Lower Risk for Necrotizing Enterocolitis in Neonates with Complex Congenital Heart Disease.

Cognata A, Kataria-Hale J, Griffiths P, Maskatia S, Rios D, O’Donnell A, Roddy DJ, Mehollin-Ray A, Hagan J, Placencia J, Hair AB.

J Pediatr. 2019 Sep 24. pii: S0022-3476(19)30993-X. doi: 10.1016/j.jpeds.2019.08.009. [Epub ahead of print]

PMID: 31561958

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  1. Delivery room emergencies in critical congenital heart diseases.

Pruetz JD, Wang SS, Noori S.

Semin Fetal Neonatal Med. 2019 Sep 24:101034. doi: 10.1016/j.siny.2019.101034. [Epub ahead of print] Review.

PMID: 31582282

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  1. Environmental Risk Factors for Congenital Heart Disease.

Kalisch-Smith JI, Ved N, Sparrow DB.

Cold Spring Harb Perspect Biol. 2019 Sep 23. pii: a037234. doi: 10.1101/cshperspect.a037234. [Epub ahead of print]

PMID: 31548181

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  1. Cerebrovascular accidents in Ebstein’s anomaly.

Tan NY, Attenhofer Jost CH, Polkinghorne MD, Vargas ER, Hodge DO, Dearani JA, Asirvatham SJ, Connolly HM, McLeod CJ.

Congenit Heart Dis. 2019 Sep 23. doi: 10.1111/chd.12841. [Epub ahead of print]

PMID: 31545019

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  1. Congenital Portosystemic Shunts in Children: Associations, Complications, and Outcomes.

DiPaola F, Trout AT, Walther AE, Gupta A, Sheridan R, Campbell KM, Tiao G, Bezerra JA, Bove KE, Patel M, Nathan JD.

Dig Dis Sci. 2019 Sep 23. doi: 10.1007/s10620-019-05834-w. [Epub ahead of print]

PMID: 31549332

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  1. Evaluation of 4D flow MRI-based non-invasive pressure assessment in aortic coarctations.

Saitta S, Pirola S, Piatti F, Votta E, Lucherini F, Pluchinotta F, Carminati M, Lombardi M, Geppert C, Cuomo F, Figueroa CA, Xu XY, Redaelli A.

J Biomech. 2019 Sep 20;94:13-21. doi: 10.1016/j.jbiomech.2019.07.004. Epub 2019 Jul 9.

PMID: 31326119

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  1. Necrotizing Enterocolitis and Associated Mortality in Neonates With Congenital Heart Disease: A Multi-Institutional Study.

Spinner JA, Morris SA, Nandi D, Costarino AT, Marino BS, Rossano JW, Shamszad P.

Pediatr Crit Care Med. 2019 Sep 20. doi: 10.1097/PCC.0000000000002133. [Epub ahead of print]

PMID: 31568264

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  1. Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood.

Hudson KM, Belcher SM, Cowley M.

Sci Rep. 2019 Sep 19;9(1):13553. doi: 10.1038/s41598-019-49807-5.

PMID: 31537853 Free PMC Article

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  1. The yield of postmortem genetic testing in sudden death cases with structural findings at autopsy.

Lahrouchi N, Raju H, Lodder EM, Papatheodorou S, Miles C, Ware JS, Papadakis M, Tadros R, Cole D, Skinner JR, Crawford J, Love DR, Pua CJ, Soh BY, Bhalshankar JD, Govind R, Tfelt-Hansen J, Winkel BG, van der Werf C, Wijeyeratne YD, Mellor G, Till J, Cohen M, Tome-Esteban M, Sharma S, Wilde AAM, Cook SA, Sheppard MN, Bezzina CR, Behr ER.

Eur J Hum Genet. 2019 Sep 18. doi: 10.1038/s41431-019-0500-8. [Epub ahead of print]

PMID: 31534214

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  1. Differing Thresholds for Overriding Parental Refusals of Life-Sustaining Treatment.

Gerdes H, Lantos J.

HEC Forum. 2019 Sep 18. doi: 10.1007/s10730-019-09384-6. [Epub ahead of print]

PMID: 31535261

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  1. The Limited Benefit of Follow-Up Echocardiograms After Repair of Tetralogy of Fallot.

Xu J, Guthrey C, Dalby S, Tang X, Daily J, Collins RT.

Pediatr Cardiol. 2019 Sep 18. doi: 10.1007/s00246-019-02210-3. [Epub ahead of print]

PMID: 31535184Similar articles

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  1. Pediatric Hemoptysis without Bronchiectasis or Cardiac Disease: Etiology, Recurrence, and Mortality.

Chiel L, Welsh S, Andren K, Mecklosky J, Alexander PMA, Casey A, Fishman MP.

J Pediatr. 2019 Sep 17. pii: S0022-3476(19)30957-6. doi: 10.1016/j.jpeds.2019.07.049. [Epub ahead of print]

PMID: 31540762

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  1. Vancomycin induced DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) in a patient with tricuspid endocarditis.

Hewitson LJ.

BMJ Case Rep. 2019 Sep 16;12(9). pii: e229590. doi: 10.1136/bcr-2019-229590.

PMID: 31527200

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  1. Searching for modifiable risk factors for neurodevelopment in congenital heart disease: Lessons from the Giessen/Zurich hypoplastic left heart syndrome experience.

Seed M.

Int J Cardiol. 2019 Sep 15;291:50-51. doi: 10.1016/j.ijcard.2019.05.038. Epub 2019 May 20. No abstract available.

PMID: 31151765

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  1. The World Heart Federation criteria raise the threshold of diagnosis for mild rheumatic heart disease: Three reviewers are better than one.

Culliford-Semmens N, Nicholson R, Tilton E, Stirling J, Sidhu K, Webb R, Wilson N.

Int J Cardiol. 2019 Sep 15;291:112-118. doi: 10.1016/j.ijcard.2019.02.058. Epub 2019 Mar 2.

PMID: 30851993

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  1. Novel Point Mutations of CITED2 Gene Are Associated with Non-familial Congenital Heart Disease (CHD) in Sporadic Pediatric Patients.

Dianatpour S, Khatami M, Heidari MM, Hadadzadeh M.

Appl Biochem Biotechnol. 2019 Sep 13. doi: 10.1007/s12010-019-03125-8. [Epub ahead of print]

PMID: 31515672

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  1. The expanding phenotypes of cohesinopathies: one ring to rule them all!

Piché J, Van Vliet PP, Pucéat M, Andelfinger G.

Cell Cycle. 2019 Sep 13:1-21. doi: 10.1080/15384101.2019.1658476. [Epub ahead of print]

PMID: 31516082

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  1. Controlling the cost of management of congenital heart disease.

Peer SM, Jonas RA.

Ann Thorac Surg. 2019 Sep 12. pii: S0003-4975(19)31270-6. doi: 10.1016/j.athoracsur.2019.07.045. [Epub ahead of print] No abstract available.

PMID: 31521596

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  1. Functional analysis of rare variants of GATA4 identified in Chinese patients with congenital heart defect.

Zhao Z, Zhan Y, Chen W, Ma X, Sheng W, Huang G.

Genesis. 2019 Sep 12:e23333. doi: 10.1002/dvg.23333. [Epub ahead of print]

PMID: 31513339

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  1. Superior vena cava obstruction after the Glenn procedure.

Jonas MC, Ramalho FS, Vicente WVA, Manso PH.

Autops Case Rep. 2019 Sep 11;9(3):e2019118. doi: 10.4322/acr.2019.118. eCollection 2019 Jul-Sep.

PMID: 31583210 Free PMC Article

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  1. Multicenter prospective clinical study to evaluate children short-term neurodevelopmental outcome in congenital heart disease (children NEURO-HEART): study protocol.

Ribera I, Ruiz A, Sánchez O, Eixarch E, Antolín E, Gómez-Montes E, Pérez-Cruz M, Cruz-Lemini M, Sanz-Cortés M, Arévalo S, Ferrer Q, Vázquez E, Vega L, Dolader P, Montoliu A, Boix H, Simões RV, Masoller N, Sánchez-de-Toledo J, Comas M, Bartha JM, Galindo A, Martínez JM, Gómez-Roig L, Crispi F, Gómez O, Carreras E, Cabero L, Gratacós E, Llurba E.

BMC Pediatr. 2019 Sep 10;19(1):326. doi: 10.1186/s12887-019-1689-y.

PMID: 31506079 Free PMC Article

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  1. Clinical Applications of MRA 4D-Flow.

Sierra-Galan LM, François CJ.

Curr Treat Options Cardiovasc Med. 2019 Sep 10;21(10):58. doi: 10.1007/s11936-019-0758-8. Review.

PMID: 31506869

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  1. Early Emotional, Behavioural and Social Development of Infants and Young Children with Congenital Heart Disease: A Systematic Review.

Clancy T, Jordan B, de Weerth C, Muscara F.

J Clin Psychol Med Settings. 2019 Sep 10. doi: 10.1007/s10880-019-09651-1. [Epub ahead of print] Review.

PMID: 31506852

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  1. Pharmacologic stress cardiovascular magnetic resonance in the pediatric population: A review of the literature, proposed protocol, and two examples in patients with Kawasaki disease.

Fares M, Critser PJ, Arruda MJ, Wilhelm CM, Rattan MS, Lang SM, Alsaied T.

Congenit Heart Dis. 2019 Sep 9. doi: 10.1111/chd.12840. [Epub ahead of print] Review.

PMID: 31498562

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Select item 31499581

 

  1. Short-term results in infants with multiple left heart obstructive lesions.

Steele JM, Komarlu R, Worley S, Alsaied T, Statile C, Erenberg FG.

Congenit Heart Dis. 2019 Sep 6. doi: 10.1111/chd.12829. [Epub ahead of print]

PMID: 31489778

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Select item 31489771

 

  1. Congenital anomalies and associated risk factors in a Saudi population: a cohort study from pregnancy to age 2 years.

Kurdi AM, Majeed-Saidan MA, Al Rakaf MS, AlHashem AM, Botto LD, Baaqeel HS, Ammari AN.

BMJ Open. 2019 Sep 5;9(9):e026351. doi: 10.1136/bmjopen-2018-026351.

PMID: 31492776 Free PMC Article

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Select item 31486566

 

  1. Prediction of biventricular repair by echocardiography in borderline ventricle.

Ma XJ, Huang GY.

Chin Med J (Engl). 2019 Sep 5;132(17):2105-2108. doi: 10.1097/CM9.0000000000000375.

PMID: 31348032

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Select item 31487070

 

  1. Congenital atresia of the left main coronary artery: Imaging feature in children.

Luo X, Li Z.

Echocardiography. 2019 Sep 5. doi: 10.1111/echo.14469. [Epub ahead of print]

PMID: 31487070

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Select item 31487058

 

  1. Early palliative care reduces stress in parents of neonates with congenital heart disease: validation of the “Baby, Attachment, Comfort Interventions”.

Callahan K, Steinwurtzel R, Brumarie L, Schechter S, Parravicini E.

J Perinatol. 2019 Sep 5. doi: 10.1038/s41372-019-0490-y. [Epub ahead of print]

PMID: 31488903

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Select item 31522920

 

  1. Tracheal Stenosis and Congenital Heart Disease in Trisomy 21.

Kylat RI.

Children (Basel). 2019 Sep 4;6(9). pii: E98. doi: 10.3390/children6090098.

PMID: 31487969 Free Article

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Select item 31483574

 

  1. Prevalence, Type, and Molecular Spectrum of NF1 Mutations in Patients with Neurofibromatosis Type 1 and Congenital Heart Disease.

Pinna V, Daniele P, Calcagni G, Mariniello L, Criscione R, Giardina C, Lepri FR, Hozhabri H, Alberico A, Cavone S, Morella AT, Mandile R, Annunziata F, Di Giosaffatte N, D’Asdia MC, Versacci P, Capolino R, Strisciuglio P, Giustini S, Melis D, Digilio MC, Tartaglia M, Marino B, De Luca A.

Genes (Basel). 2019 Sep 4;10(9). pii: E675. doi: 10.3390/genes10090675.

PMID: 31487937 Free Article

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Select item 31485699

 

  1. Safety and tolerability of macitentan in the management of pulmonary arterial hypertension: an update.

Wong AK, Channick RN.

Drug Healthc Patient Saf. 2019 Sep 3;11:71-85. doi: 10.2147/DHPS.S173050. eCollection 2019.

PMID: 31564989 Free PMC Article

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Select item 31480874

 

  1. Modifiable risk factors in congenital heart disease: Education, transition, digital health and choice architecture.

Constantine A, Barradas-Pires A, Dimopoulos K.

Eur J Prev Cardiol. 2019 Sep 3:2047487319874146. doi: 10.1177/2047487319874146. [Epub ahead of print] No abstract available.

PMID: 31480874 Free Article

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Select item 31552206

 

  1. Amiodarone-Related Pure Red Cell Aplastic Anemia and Hypothyroidism in a Child With Total Anomalous Pulmonary Venous Connection.

Ba H, Xu L, Peng H, Li X, Lin Y, Wang H, Qin Y.

Front Pediatr. 2019 Sep 3;7:361. doi: 10.3389/fped.2019.00361. eCollection 2019.

PMID: 31552206 Free PMC Article

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Select item 31522930

 

  1. Recent advances in our understanding of neurodevelopmental outcomes in congenital heart disease.

White BR, Rogers LS, Kirschen MP.

Curr Opin Pediatr. 2019 Sep 2. doi: 10.1097/MOP.0000000000000829. [Epub ahead of print]

PMID: 31483331

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Select item 31474762

 

  1. Contemporary epidemiology of infective endocarditis in patients with congenital heart disease: A UK prospective study.

Cahill TJ, Jewell PD, Denne L, Franklin RC, Frigiola A, Orchard E, Prendergast BD.

Am Heart J. 2019 Sep;215:70-77. doi: 10.1016/j.ahj.2019.05.014. Epub 2019 Jun 14.

PMID: 31299559

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Select item 31272703

 

  1. Having to Be the One: Mothers Providing Home Care to Infants With Complex Cardiac Needs.

Imperial-Perez F, Heilemann MV.

Am J Crit Care. 2019 Sep;28(5):354-360. doi: 10.4037/ajcc2019887.

PMID: 31474605

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Select item 31301121

 

  1. Abernethy malformation: Our experience from a tertiary cardiac care center and review of literature.

Azad S, Arya A, Sitaraman R, Garg A.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):240-247. doi: 10.4103/apc.APC_185_18. Review.

PMID: 31516281 Free PMC Article

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Select item 31079070

 

  1. Functional outcomes in children with anatomically repaired transposition of the great arteries with regard to congenital ventricular septal defect and coronary pattern.

Häcker AL, Reiner B, Oberhoffer R, Hager A, Ewert P, Müller J.

Arch Dis Child. 2019 Sep;104(9):851-856. doi: 10.1136/archdischild-2018-316444. Epub 2019 May 11.

PMID: 31079070

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Select item 30824490

 

  1. Congenital left heart obstruction: ethnic variation in incidence and infant survival.

Cloete E, Sadler L, Bloomfield FH, Crengle S, Percival T, Gentles TL.

Arch Dis Child. 2019 Sep;104(9):857-862. doi: 10.1136/archdischild-2018-315887. Epub 2019 Mar 1.

PMID: 30824490

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Select item 31139902

 

  1. Improving neurodevelopment in infants with complex congenital heart disease.

Harrison TM.

Birth Defects Res. 2019 Sep 1;111(15):1128-1140. doi: 10.1002/bdr2.1517. Epub 2019 May 17. Review.

PMID: 31099484

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Select item 30277407

 

  1. Enhancing efficiency and scientific impact of a clinical trials network: the Pediatric Heart Network Integrated CARdiac Data and Outcomes (iCARD) Collaborative.

Pasquali SK, Kaltman JR, Gaynor JW, McCrindle BW, Newburger JW, Anderson BR, Scheurer MA, Pinto NM, Anderson JB, Oster ME, Jacobs JP, Marino BS, Mery CM, Pearson GD.

Cardiol Young. 2019 Sep;29(9):1121-1126. doi: 10.1017/S104795111900163X. Epub 2019 Aug 6.

PMID: 31385565

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Select item 31379319

 

  1. Third time lucky: challenging secundum atrial septal defect.

Ordoñez MV, Moharem-Elgamal S, Bedair R.

Cardiol Young. 2019 Sep;29(9):1202-1205. doi: 10.1017/S1047951119001677. Epub 2019 Aug 5.

PMID: 31379319

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Select item 31379312

 

  1. Left ventricular non-compaction in a child with bicuspid aortic valve and aortic coarctation.

Karatza A, Mylonas KS, Tzifa A.

Cardiol Young. 2019 Sep;29(9):1208-1210. doi: 10.1017/S1047951119001707. Epub 2019 Aug 5.

PMID: 31379312

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Select item 31378215

 

  1. CHIP-Family intervention to improve the psychosocial well-being of young children with congenital heart disease and their families: results of a randomised controlled trial.

van der Mheen M, Meentken MG, van Beynum IM, van der Ende J, van Galen E, Zirar A, Aendekerk EWC, van den Adel TPL, Bogers AJJC, McCusker CG, Hillegers MHJ, Helbing WA, Utens EMWJ.

Cardiol Young. 2019 Sep;29(9):1172-1182. doi: 10.1017/S1047951119001732. Epub 2019 Aug 5.

PMID: 31378215

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Select item 31102479

 

  1. A new vessel segmentation algorithm for robust blood flow quantification from two-dimensional phase-contrast magnetic resonance images.

Bidhult S, Hedström E, Carlsson M, Töger J, Steding-Ehrenborg K, Arheden H, Aletras AH, Heiberg E.

Clin Physiol Funct Imaging. 2019 Sep;39(5):327-338. doi: 10.1111/cpf.12582. Epub 2019 Jun 6.

PMID: 31102479

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Select item 31230756

 

  1. Clinical study of dentocraniofacial characteristics in patients with Williams syndrome.

Matsuno S, Tsuji M, Hikita R, Matsumoto T, Baba Y, Moriyama K.

Congenit Anom (Kyoto). 2019 Sep;59(5):162-168. doi: 10.1111/cga.12316. Epub 2018 Nov 4.

PMID: 30315601

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Select item 31351549

 

  1. Associations between ambient air pollution and mortality from all causes, pneumonia, and congenital heart diseases among children aged under 5 years in Beijing, China: A population-based time series study.

Wang J, Cao H, Sun D, Qi Z, Guo C, Peng W, Sun Y, Xie Y, Liu X, Li B, Luo Y, Pan Y, Li Y, Zhang L.

Environ Res. 2019 Sep;176:108531. doi: 10.1016/j.envres.2019.108531. Epub 2019 Jun 11.

PMID: 31226628

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Select item 31504403

 

  1. Double orifice and atrioventricular septal defect: dealing with the zone of apposition†.

Pontailler M, Haidar M, Méot M, Moreau de Bellaing A, Gaudin R, Houyel L, Metton O, Moceri P, Bonnet D, Vouhé P, Raisky O.

Eur J Cardiothorac Surg. 2019 Sep 1;56(3):541-548. doi: 10.1093/ejcts/ezz085.

PMID: 30897200

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Select item 30879050

 

  1. The Functional Polymorphism R129W in the BVES Gene Is Associated with Sporadic Tetralogy of Fallot in the Han Chinese Population.

Shi Y, Li Y, Wang Y, Zhuang J, Wang H, Hu M, Mo X, Yue S, Chen Y, Fan X, Chen J, Cai W, Zhu X, Wan Y, Zhong Y, Ye X, Li F, Zhou Z, Dai G, Luo R, Ocorr K, Jiang Z, Li X, Zhu P, Wu X, Yuan W.

Genet Test Mol Biomarkers. 2019 Sep;23(9):601-609. doi: 10.1089/gtmb.2019.0085. Epub 2019 Aug 6.

PMID: 31386585

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Select item 31352143

 

  1. [The left outflow tract: Normal features].

Quarello E.

Gynecol Obstet Fertil Senol. 2019 Sep;47(9):680-688. doi: 10.1016/j.gofs.2019.07.009. Epub 2019 Jul 25. French.

PMID: 31352143

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Select item 31109891

 

  1. GATA4 screening in Iranian patients of various ethnicities affected with congenital heart disease: Co-occurrence of a novel de novo translocation (5;7) and a likely pathogenic heterozygous GATA4 mutation in a family with autosomal dominant congenital heart disease.

Kalayinia S, Maleki M, Rokni-Zadeh H, Changi-Ashtiani M, Ahangar H, Biglari A, Shahani T, Mahdieh N.

J Clin Lab Anal. 2019 Sep;33(7):e22923. doi: 10.1002/jcla.22923. Epub 2019 May 22.

PMID: 31115957

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Select item 30938874

 

  1. The impact of congenital heart disease on the psychological well-being and quality of life of Hong Kong Chinese adolescents: A cross-sectional study.

So SCY, Li WHC, Ho KY.

J Clin Nurs. 2019 Sep;28(17-18):3158-3167. doi: 10.1111/jocn.14864. Epub 2019 Apr 21.

PMID: 30938874

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Select item 31548736

 

  1. 2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT.

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D’Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh RMR, Warnecke G, Wåhlander H, Weber SC, Zartner P.

J Heart Lung Transplant. 2019 Sep;38(9):879-901. doi: 10.1016/j.healun.2019.06.022. Epub 2019 Jun 21.

PMID: 31495407

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Select item 31324444

 

  1. Intracardiac 4D Flow MRI in Congenital Heart Disease: Recommendations on Behalf of the ISMRM Flow & Motion Study Group.

Zhong L, Schrauben EM, Garcia J, Uribe S, Grieve SM, Elbaz MSM, Barker AJ, Geiger J, Nordmeyer S, Marsden A, Carlsson M, Tan RS, Garg P, Westenberg JJM, Markl M, Ebbers T.

J Magn Reson Imaging. 2019 Sep;50(3):677-681. doi: 10.1002/jmri.26858. Epub 2019 Jul 17.

PMID: 31317587

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Select item 30838716

 

  1. Parenting Stress, Sleep, and Psychological Adjustment in Parents of Infants and Toddlers With Congenital Heart Disease.

Bishop MN, Gise JE, Donati MR, Shneider CE, Aylward BS, Cohen LL.

J Pediatr Psychol. 2019 Sep 1;44(8):980-987. doi: 10.1093/jpepsy/jsz026.

PMID: 31329926

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Select item 31290975

 

  1. From Diagnoses to Ongoing Journey: Parent Experiences Following Congenital Heart Disease Diagnoses.

Williams TS, McDonald KP, Roberts SD, Chau V, Seed M, Miller SP, Sananes R.

J Pediatr Psychol. 2019 Sep 1;44(8):924-936. doi: 10.1093/jpepsy/jsz055.

PMID: 31290975

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Select item 31069392

 

  1. Cognitive Function in Pediatric Hypoplastic Left Heart Syndrome: Systematic Review and Meta-Analysis.

Siciliano RE, Prussien KV, Lee CA, Patel NJ, Murphy LK, Compas BE, Jordan LC.

J Pediatr Psychol. 2019 Sep 1;44(8):937-947. doi: 10.1093/jpepsy/jsz021.

PMID: 31069392

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Select item 30814038

 

  1. Necrotizing Enterocolitis Associated with Congenital Heart Disease: a Different Entity?

Bubberman JM, van Zoonen A, Bruggink JLM, van der Heide M, Berger RMF, Bos AF, Kooi EMW, Hulscher JBF.

J Pediatr Surg. 2019 Sep;54(9):1755-1760. doi: 10.1016/j.jpedsurg.2018.11.012. Epub 2018 Dec 13.

PMID: 30635129

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Select item 31443808

 

  1. Imaging Spectrum of Double-Outlet Right Ventricle on Multislice Computed Tomography.

Priya S, Nagpal P, Sharma A, Pandey NN, Jagia P.

J Thorac Imaging. 2019 Sep;34(5):W89-W99. doi: 10.1097/RTI.0000000000000396.

PMID: 30801451

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Select item 31380593

 

  1. Galectin-3 aggravates pulmonary arterial hypertension via immunomodulation in congenital heart disease.

Shen Q, Chen W, Liu J, Liang Q.

Life Sci. 2019 Sep 1;232:116546. doi: 10.1016/j.lfs.2019.116546. Epub 2019 Jun 6.

PMID: 31176777

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Select item 31446699

 

  1. [Case report of familial microtia combined with tetralogy of Fallot and scoliosis and literature review].

Zhang QJ, Wang DY, Wang QJ.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Sep;33(9):835-839. doi: 10.13201/j.issn.1001-1781.2019.09.009. Review. Chinese.

PMID: 31446699

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Select item 31446696

 

  1. [One novel pathologic variation in KMT2D cause Kabuki syndrome with hearing loss as the main phenotype and related research on types of deafness].

Qiu SW, Yuan YY.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Sep;33(9):820-824. doi: 10.13201/j.issn.1001-1781.2019.09.006. Review. Chinese.

PMID: 31446696

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Select item 31081250

 

  1. Diagnosis of infective endocarditis using echocardiography.

Yuan XC, Liu M, Hu J, Zeng X, Zhou AY, Chen L.

Medicine (Baltimore). 2019 Sep;98(38):e17141. doi: 10.1097/MD.0000000000017141.

PMID: 31567953 Free Article

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Select item 31490396

 

  1. A Rare Cause of Shock in an Infant: Cor Triatriatum.

Vayngortin T, Rosenfeld H, Mansour K.

Pediatr Emerg Care. 2019 Sep;35(9):e172-e173. doi: 10.1097/PEC.0000000000001162.

PMID: 28463946

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Select item 31033906

 

  1. Plasmatic NT-proBNP could help to select cases for screening echocardiography in healthy infants with Respiratory Syncytial Virus infection.

Rodriguez-Gonzalez M, Benavente-Fernandez I, Castellano-Martinez A.

Cardiol Young. 2019 Sep 30:1-2. doi: 10.1017/S1047951119002348. [Epub ahead of print]

PMID: 31566150

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Select item 31568572

 

  1. Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3.

Kühnisch J, Herbst C, Al-Wakeel-Marquard N, Dartsch J, Holtgrewe M, Baban A, Mearini G, Hardt J, Kolokotronis K, Gerull B, Carrier L, Beule D, Schubert S, Messroghli D, Degener F, Berger F, Klaassen S.

Clin Genet. 2019 Sep 30. doi: 10.1111/cge.13645. [Epub ahead of print]

PMID: 31568572

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Select item 31574005

 

  1. Dilated cardiomyopathy in children: moving beyond traditional pharmacologic therapy.

Cohen JA, Almodovar MC.

Curr Opin Cardiol. 2019 Sep 30. doi: 10.1097/HCO.0000000000000692. [Epub ahead of print]

PMID: 31574005

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Select item 31574003

 

  1. Novel ELN mutation in a Japanese family with a severe form of supravalvular aortic stenosis.

Sugiyama K, Horigome H, Lin L, Murakami T, Shiono J, Yamashiro Y, Matsuura H, Yoda H, Yanagisawa H.

Mol Genet Genomic Med. 2019 Sep 27:e986. doi: 10.1002/mgg3.986. [Epub ahead of print]

PMID: 31560829 Free Article

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Select item 31567621

 

  1. Recommendations from the Association for European Paediatric and Congenital Cardiology for training in pulmonary hypertension.

Sallmon H, Moledina S, Albert DC, Beghetti M, Berger RMF, Bonnet D, Bukova M, Koestenberger M, Meinel K, Reinhardt Z, Tulloh RMR, de Wolf D, Hansmann G.

Cardiol Young. 2019 Sep 26:1-5. doi: 10.1017/S104795111900235X. [Epub ahead of print]

PMID: 31554525

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Select item 31556238

 

  1. Clinical Course, Management, and Outcomes of Pediatric Takayasu Arteritis Initially Presenting With Hypertension: A 16-year overview.

Fan L, Zhang H, Cai J, Yang L, Wei D, Yu J, Fan J, Song L, Ma W, Lou Y.

Am J Hypertens. 2019 Sep 24;32(10):1021-1029. doi: 10.1093/ajh/hpz103.

PMID: 31278892

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Select item 31549603

 

  1. Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm.

Tremoulet AH, Jain S, Jone PN, Best BM, Duxbury EH, Franco A, Printz B, Dominguez SR, Heizer H, Anderson MS, Glodé MP, He F, Padilla RL, Shimizu C, Bainto E, Pancheri J, Cohen HJ, Whitin JC, Burns JC.

J Pediatr. 2019 Sep 24. pii: S0022-3476(19)30972-2. doi: 10.1016/j.jpeds.2019.07.064. [Epub ahead of print]

PMID: 31561960

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Select item 31547773

 

  1. How to develop a sustainable telemedicine service? A Pediatric Telecardiology Service 20 years on – an exploratory study.

Maia MR, Castela E, Pires A, Lapão LV.

BMC Health Serv Res. 2019 Sep 23;19(1):681. doi: 10.1186/s12913-019-4511-5.

PMID: 31547824 Free PMC Article

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Select item 31542952

 

  1. Ibuprofen treatment after the first days of life in preterm neonates with patent ductus arteriosus.

de Klerk JCA, van Paassen N, van Beynum IM, Flint RB, Reiss IKM, Simons SHP.

J Matern Fetal Neonatal Med. 2019 Sep 23:1-7. doi: 10.1080/14767058.2019.1667323. [Epub ahead of print]

PMID: 31510826

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Select item 31473233

 

  1. Echocardiographic Screening of Cardiovascular Status in Pediatric Sickle Cell Disease.

Allen KY, Jones S, Jackson T, DeCost G, Stephens P, Hanna BD, Cohen MS, Smith-Whitley K, Mercer-Rosa L, Natarajan SS.

Pediatr Cardiol. 2019 Sep 21. doi: 10.1007/s00246-019-02202-3. [Epub ahead of print]

PMID: 31542803

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Select item 31564593

 

  1. The role of age-specific N-terminal pro-brain natriuretic peptide cutoff values in predicting intravenous immunoglobulin resistance in Kawasaki disease: a prospective cohort study.

Shao S, Luo C, Zhou K, Hua Y, Wu M, Liu L, Liu X, Wang C.

Pediatr Rheumatol Online J. 2019 Sep 18;17(1):65. doi: 10.1186/s12969-019-0368-8.

PMID: 31533770 Free PMC Article

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Select item 31529765

 

  1. Clinical utility of exome sequencing in infantile heart failure.

Ritter A, Bedoukian E, Berger JH, Copenheaver D, Gray C, Krantz I, Izumi K, Juusola J, Leonard J, Lin K, Medne L, Santani A, Skraban C, Yang S, Ahrens-Nicklas RC.

Genet Med. 2019 Sep 17. doi: 10.1038/s41436-019-0654-3. [Epub ahead of print]

PMID: 31527676

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Select item 31540780

 

  1. Parental reactions, distress, and sense of coherence after prenatal versus postnatal diagnosis of complex congenital heart disease.

Bratt EL, Järvholm S, Ekman-Joelsson BM, Johannsmeyer A, Carlsson SÅ, Mattsson LÅ, Mellander M.

Cardiol Young. 2019 Sep 16:1-7. doi: 10.1017/S1047951119001781. [Epub ahead of print]

PMID: 31522698

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Select item 31529165

 

  1. Smaller brain volumes at two years of age in patients with hypoplastic left heart syndrome – Impact of surgical approach.

Knirsch W, Heye KN, Tuura RO, Hahn A, Wetterling K, Latal B, Schranz D, Reich B.

Int J Cardiol. 2019 Sep 15;291:42-44. doi: 10.1016/j.ijcard.2019.03.055. Epub 2019 Mar 27.

PMID: 30952528

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Select item 30772012

 

  1. Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study.

Padalino MA, Franchetti N, Sarris GE, Hazekamp M, Carrel T, Frigiola A, Horer J, Roussin R, Cleuziou J, Meyns B, Fragata J, Telles H, Polimenakos AC, Francois K, Veshti A, Salminen J, Rocafort AG, Nosal M, Vedovelli L, Protopapas E, Tumbarello R, Merola A, Pegoraro C, Motta R, Boccuzzo G, Sojak V, Rito ML, Caldaroni F, Corrado D, Basso C, Stellin G.

Int J Cardiol. 2019 Sep 15;291:189-193. doi: 10.1016/j.ijcard.2019.02.007. Epub 2019 Feb 10.

PMID: 30772012 Free Article

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Select item 31292610

 

  1. Diagnosis and Management of Anomalous Left Anterior Descending Coronary Artery from the Pulmonary Artery in an Asymptomatic Infant.

Gupta A, Husain N, Tannous P, Hauck A.

Pediatr Cardiol. 2019 Sep 14. doi: 10.1007/s00246-019-02192-2. [Epub ahead of print]

PMID: 31522266

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Select item 31525336

 

  1. A Cardio-Oncology Data Commons: Lessons from Pediatric Oncology.

Mandawat A, Eberly L, Border W.

Curr Cardiol Rep. 2019 Sep 13;21(10):128. doi: 10.1007/s11886-019-1212-y. Review.

PMID: 31520151

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Select item 31520399

 

  1. Myocardial velocity, intra-, and interventricular dyssynchrony evaluated by tissue phase mapping in pediatric heart transplant recipients.

Berhane H, Ruh A, Husain N, Robinson JD, Rigsby CK, Markl M.

J Magn Reson Imaging. 2019 Sep 12. doi: 10.1002/jmri.26916. [Epub ahead of print]

PMID: 31515865

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Select item 31513548

 

  1. Selective use of inpatient interstage management after Norwood procedure.

Hill GD, Tanem J, Ghanayem N, Rudd N, Ollberding NJ, Lavoie J, Frommelt M.

Ann Thorac Surg. 2019 Sep 10. pii: S0003-4975(19)31351-7. doi: 10.1016/j.athoracsur.2019.07.062. [Epub ahead of print]

PMID: 31518582

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Select item 31506079

 

  1. Double Orifice Mitral Valve in Tricuspid Atresia: A Rare Association.

Cantinotti M, Giordano R, Marrone C, Franchi E, Koestenberger M, Assanta N.

Pediatr Cardiol. 2019 Sep 10. doi: 10.1007/s00246-019-02204-1. [Epub ahead of print]

PMID: 31506732

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Select item 31506731

 

  1. Pure Aortic Regurgitation in Pediatric Patients.

Ibrahim A, Borrelli N, Krupickova S, Sabatino J, Avesani M, Paredes J, Josen M, D’Ascenzi F, Mondillo S, Di Salvo G.

Am J Cardiol. 2019 Sep 9. pii: S0002-9149(19)31011-2. doi: 10.1016/j.amjcard.2019.08.042. [Epub ahead of print]

PMID: 31586532

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Select item 31586531

 

  1. Diagnostic performance of CT angiography to detect pulmonary vein stenosis in children.

Barrera CA, Saul D, Rapp JB, Smith CL, White AM, Biko DM, Otero HJ.

Int J Cardiovasc Imaging. 2019 Sep 9. doi: 10.1007/s10554-019-01693-8. [Epub ahead of print]

PMID: 31502067

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Select item 31499571

 

  1. Short-term results in infants with multiple left heart obstructive lesions.

Steele JM, Komarlu R, Worley S, Alsaied T, Statile C, Erenberg FG.

Congenit Heart Dis. 2019 Sep 6. doi: 10.1111/chd.12829. [Epub ahead of print]

PMID: 31489778

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Select item 31490577

 

  1. Multimodality and multiterritory vascular imaging in a toddler with acquired, complex, and unusual aortic arch anatomy.

Bhat AH, Trent E, Kapur RP, Permut L.

Echocardiography. 2019 Sep 6. doi: 10.1111/echo.14475. [Epub ahead of print]

PMID: 31490577

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Select item 31486350

 

  1. Single right coronary artery with right ventricular fistula and congenital absence of left coronary artery: an extremely rare combination.

Yoldaş T, Beyazal M, Örün UA.

Cardiol Young. 2019 Sep 5:1-2. doi: 10.1017/S1047951119002105. [Epub ahead of print]

PMID: 31486350

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Select item 31486566

 

  1. Acute Change in Ventricular Contractility-Load Coupling After Corrective Surgery for Congenital Heart Defect: A Retrospective Cohort Study.

Oh J, Song IK, Cho J, Yun TJ, Park CS, Choi JM, Gwak M, Shin WJ.

Pediatr Cardiol. 2019 Sep 3. doi: 10.1007/s00246-019-02195-z. [Epub ahead of print]

PMID: 31482237

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Select item 31482236

 

  1. Successful treatment of infantile-onset ACAD9-related cardiomyopathy with a combination of sodium pyruvate, beta-blocker, and coenzyme Q10.

Kadoya T, Sakakibara A, Kitayama K, Yamada Y, Higuchi S, Kawakita R, Kawasaki Y, Fujino M, Murakami Y, Shimura M, Murayama K, Ohtake A, Okazaki Y, Koga Y, Yorifuji T.

J Pediatr Endocrinol Metab. 2019 Sep 2. pii: /j/jpem.ahead-of-print/jpem-2019-0205/jpem-2019-0205.xml. doi: 10.1515/jpem-2019-0205. [Epub ahead of print]

PMID: 31473688

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Select item 31530356

 

  1. Inhaled Epoprostenol for Pulmonary Hypertension Treatment in Neonates: A 12-Year Experience.

Berger-Caron F, Piedboeuf B, Morissette G, Simonyan D, Chétaille P, Pellerin A, Hébert A.

Am J Perinatol. 2019 Sep;36(11):1142-1149. doi: 10.1055/s-0038-1676483. Epub 2018 Dec 14.

PMID: 30551229

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Select item 31268349

 

  1. Utility of three-dimensional echocardiography and magnetic resonance imaging in the diagnosis of double-orifice tricuspid valve.

Mohanty S, Pavithran S, Agarwal R, Sivakumar K.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):339-341. doi: 10.4103/apc.APC_179_18.

PMID: 31516299 Free PMC Article

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Select item 31516298

 

  1. Corkscrew aortic arch in PHACES syndrome: Multimodal imaging of an unusual morphology of tortuous aortic arch in a rare but well-defined syndrome.

Sheth R, Singh AS, Pavithran S, Sivakumar K.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):333-335. doi: 10.4103/apc.APC_188_18.

PMID: 31516297 Free PMC Article

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Select item 31516296

 

  1. “Idiopathic” pulmonary arterial hypertension in early infancy: Excluding NFU1 deficiency.

Stéphanie P, Catherine B, Thierry S, Jean-Luc V, Isabelle L, Sara S, Christophe V, Marie-Cécile N.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):325-328. doi: 10.4103/apc.APC_136_18.

PMID: 31516295 Free PMC Article

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Select item 31516294

 

  1. Complete transposition of great arteries associated with total anomalous pulmonary venous connection: An unusual cause for early left ventricular myocardial mass regression.

Aggarwal N, Joshi RK, Paktin N, Agarwal M, Joshi R.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):302-304. doi: 10.4103/apc.APC_102_18.

PMID: 31516288 Free PMC Article

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Select item 31516286

 

  1. Anomalous aortic origin of the pulmonary arteries: Case series and literature review.

Agati S, Sousa CG, Calvaruso FD, Zanai R, Campanella I, Poli D, Di Pino A, Borro L, Iorio FS, Raponi M, Anderson RH, Reali S, De Zorzi A, Secinaro A.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):248-253. doi: 10.4103/apc.APC_89_18.

PMID: 31516282 Free PMC Article

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Select item 31516281

 

  1. Artificial intelligence in pediatric cardiology and cardiac surgery: Irrational hype or paradigm shift?

Chang AC.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):191-194. doi: 10.4103/apc.APC_55_19. No abstract available.

PMID: 31516273 Free PMC Article

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Select item 31079070

 

  1. Functional outcomes in children with anatomically repaired transposition of the great arteries with regard to congenital ventricular septal defect and coronary pattern.

Häcker AL, Reiner B, Oberhoffer R, Hager A, Ewert P, Müller J.

Arch Dis Child. 2019 Sep;104(9):851-856. doi: 10.1136/archdischild-2018-316444. Epub 2019 May 11.

PMID: 31079070

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Select item 31139902

 

  1. Comparison of intranasal midazolam, intranasal ketamine, and oral chloral hydrate for conscious sedation during paediatric echocardiography: results of a prospective randomised study.

Alp H, Elmacı AM, Alp EK, Say B.

Cardiol Young. 2019 Sep;29(9):1189-1195. doi: 10.1017/S1047951119001835.

PMID: 31451130

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Select item 31451126

 

  1. Semi-automated speckle-tracking for quantitative right ventricular assessment in children and adolescents.

McCloud AK, Lowisz J, Roberson DA, Lefaiver CA, Penk JS.

Cardiol Young. 2019 Sep;29(9):1149-1159. doi: 10.1017/S1047951119001641. Epub 2019 Aug 15.

PMID: 31412970

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Select item 31391137

 

  1. Discovering dad: paternal roles, responsibilities, and support needs as defined by fathers of children with complex cardiac conditions perioperatively.

Robinson J, Huskey D, Schalley S, Wratchford D, Hammel J, Weaver MS.

Cardiol Young. 2019 Sep;29(9):1143-1148. doi: 10.1017/S1047951119001586. Epub 2019 Aug 8.

PMID: 31391137

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Select item 31385565

 

  1. Enhancing efficiency and scientific impact of a clinical trials network: the Pediatric Heart Network Integrated CARdiac Data and Outcomes (iCARD) Collaborative.

Pasquali SK, Kaltman JR, Gaynor JW, McCrindle BW, Newburger JW, Anderson BR, Scheurer MA, Pinto NM, Anderson JB, Oster ME, Jacobs JP, Marino BS, Mery CM, Pearson GD.

Cardiol Young. 2019 Sep;29(9):1121-1126. doi: 10.1017/S104795111900163X. Epub 2019 Aug 6.

PMID: 31385565

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Select item 31379312

 

  1. Left ventricular non-compaction in a child with bicuspid aortic valve and aortic coarctation.

Karatza A, Mylonas KS, Tzifa A.

Cardiol Young. 2019 Sep;29(9):1208-1210. doi: 10.1017/S1047951119001707. Epub 2019 Aug 5.

PMID: 31379312

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Select item 31378215

 

  1. Focal scar and diffuse myocardial fibrosis are independent imaging markers in repaired tetralogy of Fallot.

Cochet H, Iriart X, Allain-Nicolaï A, Camaioni C, Sridi S, Nivet H, Fournier E, Dinet ML, Jalal Z, Laurent F, Montaudon M, Thambo JB.

Eur Heart J Cardiovasc Imaging. 2019 Sep 1;20(9):990-1003. doi: 10.1093/ehjci/jez068.

PMID: 30993335 Free PMC Article

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Select item 30897200

 

  1. 2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT.

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D’Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh RMR, Warnecke G, Wåhlander H, Weber SC, Zartner P.

J Heart Lung Transplant. 2019 Sep;38(9):879-901. doi: 10.1016/j.healun.2019.06.022. Epub 2019 Jun 21.

PMID: 31495407

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Select item 31324444

 

  1. Intracardiac 4D Flow MRI in Congenital Heart Disease: Recommendations on Behalf of the ISMRM Flow & Motion Study Group.

Zhong L, Schrauben EM, Garcia J, Uribe S, Grieve SM, Elbaz MSM, Barker AJ, Geiger J, Nordmeyer S, Marsden A, Carlsson M, Tan RS, Garg P, Westenberg JJM, Markl M, Ebbers T.

J Magn Reson Imaging. 2019 Sep;50(3):677-681. doi: 10.1002/jmri.26858. Epub 2019 Jul 17.

PMID: 31317587

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Select item 30838716

 

  1. Prediction of the development of pulmonary arterial hypertension with Tei Index in congenital heart diseases with left-to-right shunt.

Yücel M, Alp H, Yorulmaz A, Karaarslan S, Baysal T.

Turk Kardiyol Dern Ars. 2019 Sep;47(6):466-475. doi: 10.5543/tkda.2019.33558.

PMID: 31483301 Free Article

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Select item 31483299

 

  1. Abnormal Pulmonary Artery Bending Correlates With Increased Right Ventricular Afterload Following the Arterial Switch Operation.

Loke YH, Capuano F, Mandell J, Cross RR, Cronin I, Mass P, Balaras E, Olivieri LJ.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):572-581. doi: 10.1177/2150135119861358.

PMID: 31496415

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Select item 31496410

 

  1. Preoperative adrenal insufficiency in a neonate with congenital heart disease surgery.

Kadam SV, Tailor KB, Joshi VH, Rao SG.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):351-353. doi: 10.4103/apc.APC_108_18. No abstract available.

PMID: 31516305 Free PMC Article

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Select item 31516304

 

  1. Reply: Prevalence of hypertension and prehypertension in schoolchildren from Central India.

Patel A, Bharani A, Sharma M, Bhagwat A, Ganguli N, Chouhan DS.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):349. doi: 10.4103/apc.APC_90_19. No abstract available.

PMID: 31516303 Free PMC Article

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Select item 31516302

 

  1. Comment: Prevalence of hypertension and prehypertension in schoolchildren from Central India.

Al-Mendalawi MD.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):348. doi: 10.4103/apc.APC_64_19. No abstract available.

PMID: 31516302 Free PMC Article

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Select item 31516301

 

  1. Case of anomalous origin of right coronary artery from pulmonary artery associated with interrupted aortic arch type A, diagnosed by multidetector computed tomography angiography.

Soni N, Jain SK, Kumar A, Kadian R, Li S.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):345-347. doi: 10.4103/apc.APC_69_18.

PMID: 31516301 Free PMC Article

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Select item 31516300

 

  1. “Idiopathic” pulmonary arterial hypertension in early infancy: Excluding NFU1 deficiency.

Stéphanie P, Catherine B, Thierry S, Jean-Luc V, Isabelle L, Sara S, Christophe V, Marie-Cécile N.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):325-328. doi: 10.4103/apc.APC_136_18.

PMID: 31516295 Free PMC Article

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Select item 31516294

 

  1. Thoracic electrical impedance tomography to minimize right heart strain following cardiac arrest.

Hansen G, Holt T, Dmytrowich J.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):315-317. doi: 10.4103/apc.APC_189_18.

PMID: 31516292 Free PMC Article

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Select item 31516291

 

  1. Noonan syndrome associated with anomalous left coronary artery from the pulmonary artery in a patient with the rare RAF1 mutation: A case report and review of literature.

Garcia RU, Safa R, Evans C, Alessio D, Delius R, Shehata B.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):298-301. doi: 10.4103/apc.APC_144_18.

PMID: 31516287 Free PMC Article

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Select item 31516286

 

  1. Comparison of antistreptolysin O and anti-deoxyribonucleic B titers in healthy children to those with acute pharyngitis, acute rheumatic fever, and rheumatic heart disease aged 5-15 years.

Saini N, Kumar D, Swarnim S, Bhatt D, Kishore S.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):195-200. doi: 10.4103/apc.APC_60_18.

PMID: 31516274 Free PMC Article

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Select item 31516273

 

  1. Artificial intelligence in pediatric cardiology and cardiac surgery: Irrational hype or paradigm shift?

Chang AC.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):191-194. doi: 10.4103/apc.APC_55_19. No abstract available.

PMID: 31516273 Free PMC Article

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ACHD Featured Articles in association with ISACHD

Adult Congenital Heart Reviews of September 2019 manuscripts (sponsored by ISACHD)

 

ACHD Reviews of September 2019 Manuscripts – Sponsored by ISACHD

 

Determinants of Left Ventricular Dysfunction and Remodeling in Patients With Corrected Tetralogy of Fallot.

Andrade AC, Jerosch-Herold M, Wegner P, Gabbert DD, Voges I, Pham M, Shah R, Hedderich J, Kramer HH, Rickers C.

J Am Heart Assoc. 2019 Sep 3;8(17):e009618. doi: 10.1161/JAHA.118.009618. Epub 2019 Aug 31.

PMID: 31474177 Free PMC Article

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Select item 31450994

Take-Home Points:

  • Both impaired systolic and diastolic dysfunction of the LV, adverse remodeling with ECM expansion, myocardial atrophy and a reduced mass/volume ratio are seen in asymptomatic (NYHA I) with rTOF.
  • These markers of LV systolic dysfunction are associated with reduced peak oxygen consumption during CPET and thus a predictor of poorer outcome in rTOF. 

Commentary from Dr. Blanche Cupido (Cape Town, South Africa), section editor of ACHD Journal Watch:  In patients with repaired Tetralogy of Fallot (rTOF), pulmonary regurgitation and RV dilatation and function is usually the focus at clinical follow-up. LV dysfunction too has been found to be a predictor of death and sustained ventricular tachycardia in rTOF.  This is a cross-sectional study aiming to assess the prevalence of LV dysfunction in asymptomatic (NYHA I) patients with rTOF and to identify the associations between right heart markers of pathologic remodeling and LV remodeling. Furthermore, in a subset of patients, cardiopulmonary exercise testing was done and the effect of LV remodeling and dysfunction on age-and sex-adjusted peak exercise parameters were assessed.

This was a prospective cross-sectional study at a tertiary center in Sao Paulo, Brazil. One hundred and three consecutive patients with rTOF and NYHA I were enrolled between January 2012 and August 2016. Baseline characteristics are displayed in Table1 below.

Of the 103 patients enrolled with rTOF, 43 were female. Patients were studied at 15.1±8.7 years after surgical repair. Twenty patients had initial shunt implantations, 49% (n=51) had a transannular patch repair. Furthermore, 24% (n=25) had re-operations for mainly PR.   There were no differences in age, weight, height, BSA and blood pressure between patients and healthy controls.

Referring to table 2 above, RV mass index, indexed RV end-systolic and end-diastolic volumes as well as RV mass/volume ratios were significantly higher in rTOF patients compared to healthy controls. In patients with rTOF, LV EF, LV mass index, LV mass/volume ratio and LV/RV mass ratio were markedly reduced compared to healthy controls.  LVEDVi however did not differ between subjects and controls but correlated with RVEDVi (r=0.36, p<0;.001). LA volumes and function were also decreased compared to controls.

Table 3 shows, for each LV parameter, the proportion of patients with rTOF with values falling out of the corresponding age related 95% CI’s. In patients with rTOF, LVEF correlated with RVEF (p=0.41, p<0.001; 95%CI 0.26-0.54) and RV mass/volume ratio (p=0.33, P<0.001). In total, 23% had moderate LVEF impairment (EF 35%-45%) and 41% had mild dysfunction (EF 45-55%), 36% had normal LVEF.

Figure 2 A above shows that LV systolic dysfunction is associated with remodeling of the RV, as per RV mass-to-volume-ratio. This remained significant in a multivariate module. LV systolic dysfunction is also associated with RVESVi.

Figure 4 shows that 28% of all patients with rTOF had LV mass / volume ratio below the age-specific 5th percentile level in healthy controls.

Figure 4A

Late Gadolinium enhancement (LGE) was performed in 65 of the cohort. In 95% of these patients, the site was the ventricular septum, 46% showed LGE in the RVOT and 13.8% in other areas of the heart but not the free wall.

Cardiopulmonary testing results (CPET) were available in 70 patients with rTOF. VO2max was less than the 3rd centile in 29% of patients.

 

 

External Validation of 3 Risk Scores in Adults with Congenital Heart Disease.

Ramchandani BK, Polo L, Sánchez R, Rey J, González Á, Díez J, Aroca Á.

Korean Circ J. 2019 Sep;49(9):856-863. doi: 10.4070/kcj.2019.0015. Epub 2019 May 7.

PMID: 31165593 Free PMC Article

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Select item 31582699

Take-Home Points:

  • There was no significant difference in discrimination between the 3 mortality predictors. However, calibration showed RACHS 1 underpredicted mortality, Aristotle overpredicted mortality and Euro 1 was mis-calibrated. 

 Commentary from Dr. Helen Parry (Leeds UK), section editor of ACHD Journal Watch:

Aim:   To compare RACHS-1, Aristotle and EURO-1 risk scores in predicting in hospital mortality for patients undergoing surgery for congenital heart disease in adulthood

Methods:  The study was performed retrospectively in a single centre in Spain, looking at operations performed over a 26 year period.   The primary end-point was 30 day mortality, looked at each of the above scores and looked at correlation with mortality.  This was assessed by discrimination (ability to predict death, using the area under the curve) and calibration (accuracy of the prediction).

Results:   Six hundred and eight procedures were performed on adult patients with congenital heart disease.  There was no significant difference in discrimination between the 3 mortality predictors.  However, calibration showed RACHS 1 under predicted mortality, Aristotle over predicted mortality and Euro 1 was mis-calibrated.

Discussion:  The authors suggest that RACHS 1 and Aristotle are superior to Euro 1 in congenital heart disease patients.  RACHS 1 and Aristotle take greater account of the complexity of patients with congenital heart disease e.g. those with genetic disorders.  However, RACHS 1 and Aristotle also look at birth weight and prematurity, which are less relevant in adults relative to paediatrics.

Strengths of the study:

  • Large sample size
  • Representative case mix including high percentage of re-do sternotomies

Weaknesses of the study:

  • Single centre and retrospective
  • It would also have been useful to have more details on the mortalities e.g. why did a 32 year old male attending for a PVR die of a myocardial infarction?

 

 

Assessment and Implications of Right Ventricular Afterload in Tetralogy of Fallot.

Egbe AC, Taggart NW, Reddy YNV, Sufian M, Banala K, Vojjini R, Najam M, Osman K, Obokata M, Borlaug BA.

Am J Cardiol. 2019 Sep 9. pii: S0002-9149(19)31003-3. doi: 10.1016/j.amjcard.2019.08.035. [Epub ahead of print]

PMID: 31586531

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Select item 31501090

 Take-Home Points:

  • High RV pressure after repair of tetralogy of Fallot (TOF) adversely affects clinical outcomes.
  • Invasively measured right ventricular systolic pressure (RVSP) and TOF with pulmonary atresia are independent risk factor for death and/ or heart transplant.
  • Doppler-derived RVSP has good correlation between invasively measured RVSP and is independently predictive of death and / or heart transplant.

 Commentary by Dr. M.C. Leong (Kuala Lumpur, Malaysia), section editor of ACHD Journal Watch:  In the attempt to preserve the pulmonary valve during surgery, surgeons usually leave patients with residual right ventricular outflow tract (RVOT) obstruction either at the pulmonary annular or perivalvular level after the repair of tetralogy of Fallot (TOF). Often, this is seen as benign as the residual RVOT is usually not high and in fact, may even promote development of restrictive right ventricular physiology which may mitigate progressive right ventricular dilatation. However, if the right ventricular systolic pressure is left high for a chronic period of time, its long term effect onto the right ventricle is unknown.  This paper studied the effect of significant elevated right ventricular afterload, whether it independently affects the clinical outcomes of patients with TOF.

This is a retrospective study, looking at 266 patients who underwent cardiac catheterization during follow up. Of these, 175 (66%) patients had significant RVOT obstruction, which was defined as a peak-to-peak gradient of greater than 36mmHg, on direct measurement. Within this cohort, 212 patients had echocardiography within 48 hours of the cardiac catheterization.

These patients were followed up for 12.9 ± 7.3 years from the time of invasive study. During this period 35 (13%) patients died at a mean age of 49 ± 14 years. Of these, 27 patients had significant RVOT obstruction while 8 patients did not. There was no significant difference in mortality between patients with versus without significant RVOT obstruction. Invasively measured RVSP and TOF-pulmonary atresia were independent risk factors for death and/or heart transplant.

There was a strong correlation between the invasively measured right ventricular systolic pressure (RVSP) and that of echocardiographic Doppler-derived, with a mean difference of +6mmHg suggesting that follow up using echocardiography is accurate yet noninvasive. Doppler-derived RSVP was independently predictive of death and / or transplant.

It is interesting to note that TOF-pulmonary atresia itself was a risk factor for death and heart failure. With increasing attempts of unifocalization of the aorto-pulmonary collaterals and incorporating them into the pulmonary arterial tree as well as total repair when the pulmonary arterial size is less than desired, many patients are left with high RVSP and this paper underscores the effects of having a high RVSP in this group of patients. A caveat to this paper is the fact that patients who undergo invasive investigation are those with poorer hemodynamics and inherently are at a higher risk of death and heart failure. Hence many of these patients are higher risk patients compared to the general TOF population.

 

 

 ACHD Sept 2019

  1. Metabolic syndrome in adults with congenital heart disease and increased intima-media thickness.

Häcker AL, Oberhoffer R, Hager A, Ewert P, Müller J.

Congenit Heart Dis. 2019 Sep 26. doi: 10.1111/chd.12845. [Epub ahead of print]

PMID: 31556238

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Select item 31557345

  1. What is new in the 2018 ESC guidelines for the management of cardiovascular diseases during pregnancy?

Lang IM.

Wien Klin Wochenschr. 2019 Sep 23. doi: 10.1007/s00508-019-1529-y. [Epub ahead of print] Review.

PMID: 31549230

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Select item 31544351

 

  1. Health behaviours reported by adults with congenital heart disease across 15 countries.

Holbein CE, Peugh J, Veldtman GR, Apers S, Luyckx K, Kovacs AH, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Moons P; APPROACH-IS consortium and the International Society for Adult Congenital Heart Disease (ISACHD).

Eur J Prev Cardiol. 2019 Sep 17:2047487319876231. doi: 10.1177/2047487319876231. [Epub ahead of print]

PMID: 31529991

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Select item 31530101

 

  1. Receipt of American Heart Association-Recommended Preconception Health Care Among Privately Insured Women With Congenital Heart Defects, 2007-2013.

Farr SL, Downing KF, Ailes EC, Gurvitz M, Koontz G, Tran EL, Alverson CJ, Oster ME.

J Am Heart Assoc. 2019 Sep 17;8(18):e013608. doi: 10.1161/JAHA.119.013608. Epub 2019 Sep 12.

PMID: 31510829 Free Article

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Select item 31540762

 

  1. Factors Associated With Increased Exercise in Adults With Congenital Heart Disease.

Connor B, Osborne W, Peir G, Smith M, John A.

Am J Cardiol. 2019 Sep 15;124(6):947-951. doi: 10.1016/j.amjcard.2019.05.073. Epub 2019 Jun 25.

PMID: 31327487

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Select item 31151765

 

  1. Long-surviving Anomalous Origin of the Right Pulmonary Artery from the Ascending Aorta Complicated with Pulmonary Arteriovenous Fistula.

Ueno R, Yagi S, Bando M, Sata M.

Intern Med. 2019 Sep 15;58(18):2749-2750. doi: 10.2169/internalmedicine.2455-18. Epub 2019 Jun 7. No abstract available.

PMID: 31178488 Free Article

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Select item 31521197

 

  1. Learning strategies among adult CHD fellows.

Bokma JP, Daily JA, Kovacs AH, Oechslin EN, Baumgartner H, Khairy P, Mulder BJM, Veldtman GR.

Cardiol Young. 2019 Sep 10:1-5. doi: 10.1017/S1047951119002063. [Epub ahead of print]

PMID: 31502529

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Select item 31506869

 

  1. Pregnant women with Uncorrected Congenital Heart Disease: Heart failure and mortality.

Sliwa K, Baris L, Sinning C, Zengin-Sahm E, Gumbiene L, Yaseen IF, Youssef G, Johnson M, Al-Farhan H, Lelonek M, Hall R, Roos-Hesselink J.

JACC Heart Fail. 2019 Sep 7. pii: S2213-1779(19)30731-0. doi: 10.1016/j.jchf.2019.09.001. [Epub ahead of print]

PMID: 31511192

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Select item 31494702

 

  1. Opinions of general and adult congenital heart disease cardiologists on care for adults with congenital heart disease in Belgium: a qualitative study.

Willems R, de Hosson M, De Backer J, Annemans L.

Cardiol Young. 2019 Sep 6:1-7. doi: 10.1017/S1047951119002245. [Epub ahead of print]

PMID: 31489832

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Select item 31489778

 

  1. Coronary artery disease screening in adults with congenital heart disease prior to cardiac surgery.

Johnson B, Buelow M, Earing M, Cohen S, Bartz P, Ginde S.

Congenit Heart Dis. 2019 Sep 6. doi: 10.1111/chd.12839. [Epub ahead of print]

PMID: 31489771

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Select item 31489769

 

  1. Flying the nest: are we doing enough to achieve successful transition in young people with congenital heart disease?

Reekie J.

Heart. 2019 Sep 6. pii: heartjnl-2019-315727. doi: 10.1136/heartjnl-2019-315727. [Epub ahead of print] No abstract available.

PMID: 31492700

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Select item 31492699

 

  1. Hepatic Pathology in Patients after Fontan Operation: A CT imaging study.

Chen YC, Weng KP, Chien KJ, Chen BH, Hsieh KS, Ta IH, Huang SH, Peng HH, Huang JS, Wu MT.

J Chin Med Assoc. 2019 Sep 6. doi: 10.1097/JCMA.0000000000000185. [Epub ahead of print]

PMID: 31517771

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Select item 31492776

 

  1. Therapeutic apheresis during pregnancy: A single center experience.

Colpo A, Marson P, Pavanello F, Tison T, Gervasi MT, Zambon A, Ruffatti A, De Silvestro G, Hoxha A.

Transfus Apher Sci. 2019 Sep 5. pii: S1473-0502(19)30185-5. doi: 10.1016/j.transci.2019.07.009. [Epub ahead of print]

PMID: 31522920

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Select item 31487969

 

  1. Pregnancy Outcomes in Women After the Arterial Switch Operation.

Fricke TA, Konstantinov IE, Grigg LE, Zentner D.

Heart Lung Circ. 2019 Sep 3. pii: S1443-9506(19)31411-8. doi: 10.1016/j.hlc.2019.07.016. [Epub ahead of print]

PMID: 31522930

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Select item 31474177

 

  1. Determinants of Left Ventricular Dysfunction and Remodeling in Patients With Corrected Tetralogy of Fallot.

Andrade AC, Jerosch-Herold M, Wegner P, Gabbert DD, Voges I, Pham M, Shah R, Hedderich J, Kramer HH, Rickers C.

J Am Heart Assoc. 2019 Sep 3;8(17):e009618. doi: 10.1161/JAHA.118.009618. Epub 2019 Aug 31.

PMID: 31474177 Free PMC Article

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Select item 31450994

 

  1. Metabolic Response to Stress by the Immature Right Ventricle Exposed to Chronic Pressure Overload.

Kajimoto M, Nuri M, Isern NG, Robillard-Frayne I, Des Rosiers C, Portman MA.

J Am Heart Assoc. 2019 Sep 3;8(17):e013169. doi: 10.1161/JAHA.119.013169. Epub 2019 Aug 27.

PMID: 31450994 Free PMC Article

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Select item 31431113

 

  1. Exploring the Prognostic Value of Novel Markers in Adults With a Systemic Right Ventricle.

Geenen LW, van Grootel RWJ, Akman K, Baggen VJM, Menting ME, Eindhoven JA, Cuypers JAAE, Boersma E, van den Bosch AE, Roos-Hesselink JW.

J Am Heart Assoc. 2019 Sep 3;8(17):e013745. doi: 10.1161/JAHA.119.013745. Epub 2019 Aug 21.

PMID: 31431113 Free PMC Article

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Select item 31478249

 

  1. Mechanism and Risk Factors for Death in Adults With Tetralogy of Fallot.

Egbe AC, Kothapalli S, Borlaug BA, Ammash NM, Najam M, Bajwa N, Tarek K, Matthew J, Connolly HM.

Am J Cardiol. 2019 Sep 1;124(5):803-807. doi: 10.1016/j.amjcard.2019.05.048. Epub 2019 Jun 7.

PMID: 31272701

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Select item 31474605

 

  1. Aortic valvular imaging with cardiovascular magnetic resonance: seeking for comprehensiveness.

De Rubeis G, Galea N, Ceravolo I, Dacquino GM, Carbone I, Catalano C, Francone M.

Br J Radiol. 2019 Sep;92(1101):20170868. doi: 10.1259/bjr.20170868. Epub 2019 Jul 18. Review.

PMID: 30277407

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Select item 31385565

 

  1. State-of-the-Art Review: Echocardiography in Pulmonary Hypertension.

Cordina RL, Playford D, Lang I, Celermajer DS.

Heart Lung Circ. 2019 Sep;28(9):1351-1364. doi: 10.1016/j.hlc.2019.03.003. Epub 2019 Apr 30. Review.

PMID: 31109891

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Select item 30904484

 

  1. [Medical care of adults with congenital heart diseases : Present and future].

Neidenbach R, Achenbach S, Andonian C, Beckmann J, Biber S, Dittrich S, Ewert P, Freilinger S, Huntgeburth M, Nagdyman N, Oberhoffer R, Pieper L, von Kodolitsch Y, Weyand M, Bauer UMM, Kaemmerer H.

Herz. 2019 Sep;44(6):553-572. doi: 10.1007/s00059-019-4820-9. German.

PMID: 31263905

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Select item 31197456

 

  1. Does gender affect the prognosis and risk of complications in patients with congenital heart disease in the modern era?

D’Alto M, Budts W, Diller GP, Mulder B, Egidy Assenza G, Oreto L, Ciliberti P, Bassareo PP, Gatzoulis MA, Dimopoulos K.

Int J Cardiol. 2019 Sep 1;290:156-161. doi: 10.1016/j.ijcard.2019.05.010. Epub 2019 May 4.

PMID: 31085083

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Select item 31141298

 

  1. Cardiovascular risk factors and arterial thrombotic events in congenital heart disease patients.

Martínez-Quintana E, Rodríguez-Hernández JL, Rodríguez-González F, Riaño-Ruiz M, Fraguela-Medina C, Girolimetti A, Jiménez-Rodríguez S.

Int J Clin Pract. 2019 Sep;73(9):1-8. doi: 10.1111/ijcp.13378. Epub 2019 Jun 28.

PMID: 31141298

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Select item 31089681

 

  1. Fontan-associated liver disease: A review.

Gordon-Walker TT, Bove K, Veldtman G.

J Cardiol. 2019 Sep;74(3):223-232. doi: 10.1016/j.jjcc.2019.02.016. Epub 2019 Mar 28. Review.

PMID: 30928109

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Select item 31343584

 

  1. Exercise Training in Adults With Congenital Heart Disease: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Li X, Chen N, Zhou X, Yang Y, Chen S, Song Y, Sun K, Du Q.

J Cardiopulm Rehabil Prev. 2019 Sep;39(5):299-307. doi: 10.1097/HCR.0000000000000420.

PMID: 31343584

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Select item 31130315

 

  1. Cardiac Magnetic Resonance Evaluation of Pulmonary Transit Time and Blood Volume in Adult Congenital Heart disease.

Ait Ali L, Aquaro GD, Peritore G, Ricci F, De Marchi D, Emdin M, Passino C, Festa P.

J Magn Reson Imaging. 2019 Sep;50(3):779-786. doi: 10.1002/jmri.26684. Epub 2019 Mar 5.

PMID: 30838716

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Select item 30714251

 

  1. Transition Readiness in Adolescents and Young Adults with Heart Disease: Can We Improve Quality of Life?

Uzark K, Afton K, Yu S, Lowery R, Smith C, Norris MD.

J Pediatr. 2019 Sep;212:73-78. doi: 10.1016/j.jpeds.2019.04.060. Epub 2019 Jun 8.

PMID: 31182220

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Select item 31329926

 

  1. Differential impact of physical activity type on depression in adults with congenital heart disease: A multi-center international study.

Ko JM, White KS, Kovacs AH, Tecson KM, Apers S, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Wang JK, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, Callus E, Kutty S, Moons P, Cedars AM; APPROACH-IS consortium and International Society for Adult Congenital Heart Disease (ISACHD).

J Psychosom Res. 2019 Sep;124:109762. doi: 10.1016/j.jpsychores.2019.109762. Epub 2019 Jul 5.

PMID: 31443808

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Select item 31026793

 

  1. Risk Stratification Models for Adults with Congenital Heart Disease.

Park HK.

Korean Circ J. 2019 Sep;49(9):864-865. doi: 10.4070/kcj.2019.0259. No abstract available.

PMID: 31456377 Free PMC Article

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Select item 31165593

 

  1. External Validation of 3 Risk Scores in Adults with Congenital Heart Disease.

Ramchandani BK, Polo L, Sánchez R, Rey J, González Á, Díez J, Aroca Á.

Korean Circ J. 2019 Sep;49(9):856-863. doi: 10.4070/kcj.2019.0015. Epub 2019 May 7.

PMID: 31165593 Free PMC Article

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Select item 31582699

 

  1. Endocarditis and bacterial brain abscess in a young woman with a single atrium, patent ductus arteriosus, and Eisenmenger syndrome: A case report.

Wang W, Feng P, Wang L, Dong Q, Huang W.

Medicine (Baltimore). 2019 Sep;98(36):e17044. doi: 10.1097/MD.0000000000017044.

PMID: 31490396 Free PMC Article

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Select item 31393094

 

  1. Hypertrophic cardiomyopathy: New hope for an old disease.

Larkin G, Bellomo T, Caze L.

Nursing. 2019 Sep;49(9):24-31. doi: 10.1097/01.NURSE.0000577688.41805.80.

PMID: 31365456

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Select item 30484210

 

  1. Prediction of the development of pulmonary arterial hypertension with Tei Index in congenital heart diseases with left-to-right shunt.

Yücel M, Alp H, Yorulmaz A, Karaarslan S, Baysal T.

Turk Kardiyol Dern Ars. 2019 Sep;47(6):466-475. doi: 10.5543/tkda.2019.33558.

PMID: 31483301 Free Article

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Select item 30334300

 

  1. Maternal right ventricular function, uteroplacental circulation in first trimester and pregnancy outcome in women with congenital heart disease.

Siegmund AS, Kampman MAM, Oudijk MA, Mulder BJM, Sieswerda GTJ, Koenen SV, Hummel YM, de Laat MWM, Sollie-Szarynska KM, Groen H, van Dijk APJ, van Veldhuisen DJ, Bilardo CM, Pieper PG.

Ultrasound Obstet Gynecol. 2019 Sep;54(3):359-366. doi: 10.1002/uog.20148.

PMID: 30334300

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Select item 31496419

 

  1. Congenital Heart Disease and Thyroid Dysfunction: Combination, Association, and Implication.

Lerner RK, Gruber N, Pollak U.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):604-615. doi: 10.1177/2150135119857704.

PMID: 31496400

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Select item 31496399

 

  1. Late “failing” Fontan: 20-year experience of a tertiary centre in Portugal.

Correia-Costa A, Granja S.

Cardiol Young. 2019 Sep 24:1-2. doi: 10.1017/S104795111900221X. [Epub ahead of print] No abstract available.

PMID: 31549603

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Select item 31537267

 

  1. Does Colchicine Substitute Corticosteroids in Treatment of Idiopathic and Viral Pediatric Pericarditis?

Vukomanovic V, Prijic S, Krasic S, Borovic R, Ninic S, Nesic D, Bjelakovic B, Popovic S, Stajević M, Petrović G.

Medicina (Kaunas). 2019 Sep 20;55(10). pii: E609. doi: 10.3390/medicina55100609.

PMID: 31547038 Free Article

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Select item 31539915

 

  1. Health behaviours reported by adults with congenital heart disease across 15 countries.

Holbein CE, Peugh J, Veldtman GR, Apers S, Luyckx K, Kovacs AH, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Moons P; APPROACH-IS consortium and the International Society for Adult Congenital Heart Disease (ISACHD).

Eur J Prev Cardiol. 2019 Sep 17:2047487319876231. doi: 10.1177/2047487319876231. [Epub ahead of print]

PMID: 31529991

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Select item 31527676

 

  1. Does Restrictive Lung Function Affect the Exercise Capacity in Patients with Repaired Tetralogy of Fallot?

Akam-Venkata J, Sriram C, French M, Smith R, Aggarwal S.

Pediatr Cardiol. 2019 Sep 17. doi: 10.1007/s00246-019-02205-0. [Epub ahead of print]

PMID: 31529227

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Select item 31522698

 

  1. Assessment and Implications of Right Ventricular Afterload in Tetralogy of Fallot.

Egbe AC, Taggart NW, Reddy YNV, Sufian M, Banala K, Vojjini R, Najam M, Osman K, Obokata M, Borlaug BA.

Am J Cardiol. 2019 Sep 9. pii: S0002-9149(19)31003-3. doi: 10.1016/j.amjcard.2019.08.035. [Epub ahead of print]

PMID: 31586531

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Select item 31501090

 

  1. Reduced brain mammillary body volumes and memory deficits in adolescents who have undergone the Fontan procedure.

Cabrera-Mino C, Roy B, Woo MA, Singh S, Moye S, Halnon NJ, Lewis AB, Kumar R, Pike NA.

Pediatr Res. 2019 Sep 9. doi: 10.1038/s41390-019-0569-3. [Epub ahead of print]

PMID: 31499515

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Select item 31493782

 

  1. Ascending Aortic Aneurysm After Repair of Aortico-Left Ventricular Tunnel.

Jhou HJ, Ke LY, Wu JR, Chen YF.

Pediatr Cardiol. 2019 Sep 3. doi: 10.1007/s00246-019-02184-2. [Epub ahead of print]

PMID: 31482238

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Select item 31482237

 

  1. Can computed tomodensitometry predict ventricular pseudoaneurysm occurrence after heart valve endocarditis?

Fouilloux V, Aldebert P, Gorincour G.

Cardiol Young. 2019 Sep;29(9):1206-1207. doi: 10.1017/S1047951119001690. Epub 2019 Aug 22.

PMID: 31434603

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Select item 31412970

 

  1. Exercise Training in Adults With Congenital Heart Disease: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Li X, Chen N, Zhou X, Yang Y, Chen S, Song Y, Sun K, Du Q.

J Cardiopulm Rehabil Prev. 2019 Sep;39(5):299-307. doi: 10.1097/HCR.0000000000000420.

PMID: 31343584

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Select item 31257650

 

  1. Cardiac Magnetic Resonance Evaluation of Pulmonary Transit Time and Blood Volume in Adult Congenital Heart disease.

Ait Ali L, Aquaro GD, Peritore G, Ricci F, De Marchi D, Emdin M, Passino C, Festa P.

J Magn Reson Imaging. 2019 Sep;50(3):779-786. doi: 10.1002/jmri.26684. Epub 2019 Mar 5.

PMID: 30838716

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Select item 30714251

 

  1. A Review of Psychosocial Factors of Marfan Syndrome: Adolescents, Adults, Families, and Providers.

Nielsen C, Ratiu I, Esfandiarei M, Chen A, Selamet Tierney ES.

J Pediatr Genet. 2019 Sep;8(3):109-122. doi: 10.1055/s-0039-1693663. Epub 2019 Jul 25. Review.

PMID: 31406616

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Select item 31404392

 

  1. Differential impact of physical activity type on depression in adults with congenital heart disease: A multi-center international study.

Ko JM, White KS, Kovacs AH, Tecson KM, Apers S, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Wang JK, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, Callus E, Kutty S, Moons P, Cedars AM; APPROACH-IS consortium and International Society for Adult Congenital Heart Disease (ISACHD).

J Psychosom Res. 2019 Sep;124:109762. doi: 10.1016/j.jpsychores.2019.109762. Epub 2019 Jul 5.

PMID: 31443808

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Select item 29973131

 

  1. Bands in the Heart: Multimodality Imaging Review.

Rajiah P, MacNamara J, Chaturvedi A, Ashwath R, Fulton NL, Goerne H.

Radiographics. 2019 Sep-Oct;39(5):1238-1263. doi: 10.1148/rg.2019180176. Epub 2019 Aug 2.

PMID: 31373865

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Select item 31356765

 

 

ACHD Electrophysiology Featured Articles

Congenital and Pediatric Cardiac EP Reviews of September 2019 Manuscripts

Congenital and Pediatric Cardiac EP Reviews of September 2019 Manuscripts

 Long term follow-up after ventricular tachycardia ablation in patients with congenital heart disease.

Yang J, Brunnquell M, Liang JJ, Callans DJ, Garcia FC, Lin D, Frankel DS, Kay J, Marchlinski FE, Tzou W, Sauer WH, Liu B, Ruckdeschel ES, Collins K, Santangeli P, Nguyen DT.

J Cardiovasc Electrophysiol. 2019 Sep;30(9):1560-1568. doi: 10.1111/jce.13996. Epub 2019 Jun 11.

PMID: 31111602

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Select item 31115957

Take-Home Points: 

  • This was a large two-center study of CHD VT ablation with 5-year follow up data.
  • The mechanism of VT in congenital heart disease was primarily scar-related reentry (80%), followed by focal (15%) and non-scar related reentry (5%).
  • Scar-related reentry was more commonly seen among patients with TOF vs other CHD anatomies.
  • Acute complete procedural success could be achieved in 75% of patients overall, with recurrence in 20% of patients.
  • Acute procedural success was strongly associated with ventricular arrhythmia-free survival.

 Commentary by Dr. Jeremy Moore (Los Angeles) Congenital and Pediatric Cardiac EP section editor:  This was a retrospective two-center study of VT catheter ablation outcomes over a 7-year period from 2010 to 2017. Forty-eight patients with variable CHD anatomy were identified, most commonly TOF in 29 (60%), Ebstein’s anomaly in 4 (8%), and bicuspid aortic valve in 4 (8%). Approximately three-quarters had an ICD in place and half had failed antiarrhythmic drugs. Overall, 77 unique VTs were induced, of which approximately half (52%) were hemodynamically stable and could be localized with activation or entrainment mapping. The remainder were identified by pace mapping. The mechanism was scar-related reentry in 81%, non-scar (His-Purkinje)-related reentry in 16%, and focal (mainly outflow tract in 73%) in the remaining 4%. His-Purkinje reentry (4) was seen only observed among patients with Ebstein’s anomaly (2) and TOF (2). Interestingly, the authors noted that VT CL was shorter for patients with preserved RV function versus RV dysfunction (286 ± 7 ms vs 322 ± 18 ms; P = .0246). In addition, TOF patients were more likely to manifest scar-related reentry.

Acute success was achieved in 75% of patients, with recurrent VT in 21% over nearly 5-year follow up. Patients with acute success were less likely to experience recurrent VT (17% vs. 54%, p=0.02). Five of 10 patients with recurrence were taken for a second catheter ablation procedure. In 1 patient, the same anatomical isthmus was targeted; and in 2 others, a separate site was targeted (right coronary cusp in 1 and RBB in 1). The final 2 patients had no inducible VT at repeat catheter ablation and substrate-based ablation was pursued. There were no major complications from catheter ablation. At last follow up, only 8 patients remained on antiarrhythmic drugs.

This study is notable as it is the largest series to date, describing catheter ablation outcomes in mixed CHD cohort with VT. The acute efficacy of 75% with no major complications suggest that this approach is a very reasonable therapeutic modality for affected patients. Similar to a smaller prior description from the Mayo Clinic [Martin et al. Heart Rhythm 2016;13:1449-1454), mechanisms were predominantly scar-related and anatomically based, with a significant number of focal VTs. Although reassuring, the issue of catheter ablation as a substitute for ICD placement was not fully resolved from this interesting experience.

 

 

CHD EP Sept 2019

  1. Electroencephalographic patterns preceding cardiac arrest in neonates following cardiac surgery.

Massey SL, Abend NS, Gaynor JW, Licht DJ, Nadkarni VM, Topjian AA, Xiao R, Naim MY.

Resuscitation. 2019 Sep 24;144:67-74. doi: 10.1016/j.resuscitation.2019.09.005. [Epub ahead of print]

PMID: 31560988

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Select item 31582282

  1. Efficacy and safety of catheter ablation for atrial fibrillation in congenital heart disease – A systematic review and meta-analysis.

Pranata R, Tondas AE, Yonas E, Chintya V, Yamin M.

Indian Pacing Electrophysiol J. 2019 Sep 18. pii: S0972-6292(19)30116-0. doi: 10.1016/j.ipej.2019.09.005. [Epub ahead of print]

PMID: 31541679 Free Article

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Select item 31533759

 

  1. Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest.

van der Werf C, Lieve KV, Bos JM, Lane CM, Denjoy I, Roses-Noguer F, Aiba T, Wada Y, Ingles J, Leren IS, Rudic B, Schwartz PJ, Maltret A, Sacher F, Skinner JR, Krahn AD, Roston TM, Tfelt-Hansen J, Swan H, Robyns T, Ohno S, Roberts JD, van den Berg MP, Kammeraad JA, Probst V, Kannankeril PJ, Blom NA, Behr ER, Borggrefe M, Haugaa KH, Semsarian C, Horie M, Shimizu W, Till JA, Leenhardt A, Ackerman MJ, Wilde AA.

Eur Heart J. 2019 Sep 14;40(35):2953-2961. doi: 10.1093/eurheartj/ehz309.

PMID: 31145795

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Select item 31522246

 

  1. Extremely short setting of optimal sensed atrioventricular interval in patients after Fontan procedure with implanted dual-chamber pacemaker.

Miyazaki A, Yoshimura SI, Matsutani H, Miyake M, Negishi J, Yamanaka K, Yamada O, Doi H, Ohuchi H.

Cardiol Young. 2019 Sep 11:1-5. doi: 10.1017/S1047951119002257. [Epub ahead of print]

PMID: 31507257

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Select item 31508848

 

  1. Zero Fluoroscopy During Ablation of Right-Sided Supraventricular Tachycardia Substrates in a Pediatric Population – Initial Experience in Taiwan.

Tseng WC, Wu MH, Lu CW, Wu KL, Wang JK, Lin MT, Chen CA, Chiu SN.

Acta Cardiol Sin. 2019 Sep;35(5):476-483. doi: 10.6515/ACS.201909_35(5).20190211A.

PMID: 31571796 Free PMC Article

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Select item 31299559

 

  1. Indian guidelines for indications and timing of intervention for common congenital heart diseases: Revised and updated consensus statement of the Working group on management of congenital heart diseases.

Saxena A, Relan J, Agarwal R, Awasthy N, Azad S, Chakrabarty M, Dagar KS, Devagourou V, Dharan BS, Gupta SK, Iyer KS, Jayranganath M, Joshi R, Kannan B, Katewa A, Kohli V, Kothari SS, Krishnamoorthy KM, Kulkarni S, Kumar RM, Kumar RK, Maheshwari S, Manohar K, Marwah A, Mishra S, Mohanty SR, Murthy KS, Rao KN, Suresh PV, Radhakrishnan S, Rajashekar P, Ramakrishnan S, Rao N, Rao SG, Chinnaswamy Reddy HM, Sharma R, Shivaprakash K, Subramanyan R, Kumar RS, Talwar S, Tomar M, Verma S, Vijaykumar R.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):254-286. doi: 10.4103/apc.APC_32_19.

PMID: 31516283 Free PMC Article

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Select item 31516281

 

  1. Efficacy of catheter ablation for atrial fibrillation in patients with congenital heart disease.

Guarguagli S, Kempny A, Cazzoli I, Barracano R, Gatzoulis MA, Dimopoulos K, Ernst S.

Europace. 2019 Sep 1;21(9):1334-1344. doi: 10.1093/europace/euz157.

PMID: 31168581

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Select item 31004150

 

  1. Long-term results of atrial maze surgery in patients with congenital heart disease.

Gonzalez Corcia MC, Walsh EP, Emani S.

Europace. 2019 Sep 1;21(9):1345-1352. doi: 10.1093/europace/euz056.

PMID: 31004150

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Select item 31432698

 

  1. Patterns of amiodarone-induced thyroid dysfunction in infants and children.

Creo A, Anderson H, Cannon B, Lteif A, Kumar S, Tebben P, Iqbal AM, Ramakrishna A, Pittock S.

Heart Rhythm. 2019 Sep;16(9):1436-1442. doi: 10.1016/j.hrthm.2019.03.015. Epub 2019 Mar 21.

PMID: 30904484

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Select item 30412778

 

  1. 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.

Writing Committee Members, Kusumoto FM, Schoenfeld MH, Barrett C, Edgerton JR, Ellenbogen KA, Gold MR, Goldschlager NF, Hamilton RM, Joglar JA, Kim RJ, Lee R, Marine JE, McLeod CJ, Oken KR, Patton KK, Pellegrini CN, Selzman KA, Thompson A, Varosy PD.

Heart Rhythm. 2019 Sep;16(9):e128-e226. doi: 10.1016/j.hrthm.2018.10.037. Epub 2018 Nov 6. No abstract available.

PMID: 30412778

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Select item 30412777

 

  1. 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society.

Writing Committee Members, Kusumoto FM, Schoenfeld MH, Barrett C, Edgerton JR, Ellenbogen KA, Gold MR, Goldschlager NF, Hamilton RM, Joglar JA, Kim RJ, Lee R, Marine JE, McLeod CJ, Oken KR, Patton KK, Pellegrini CN, Selzman KA, Thompson A, Varosy PD.

Heart Rhythm. 2019 Sep;16(9):e227-e279. doi: 10.1016/j.hrthm.2018.10.036. Epub 2018 Nov 6. No abstract available.

PMID: 30412777

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Select item 31263905

 

  1. Novel Strategy of Subcutaneous Implantable Cardioverter Defibrillator Implantation Under Regional Anesthesia.

Braver O, Semyonov M, Reina Y, Konstantino Y, Haim M, Winter J.

J Cardiothorac Vasc Anesth. 2019 Sep;33(9):2513-2516. doi: 10.1053/j.jvca.2019.04.024. Epub 2019 Apr 26. No abstract available.

PMID: 31130315

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Select item 31072707

 

  1. How to deliver personalized cardiac resynchronization therapy through the precise measurement of the acute hemodynamic response: Insights from the iSpot trial.

Shun-Shin MJ, Miyazawa AA, Keene D, Sterliński M, Sokal A, Van Heuverswyn F, Rinaldi CA, Cornelussen R, Stegemann B, Francis DP, Whinnett Z.

J Cardiovasc Electrophysiol. 2019 Sep;30(9):1610-1619. doi: 10.1111/jce.14001. Epub 2019 Jun 25.

PMID: 31115945

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Select item 31111602

 

  1. Long term follow-up after ventricular tachycardia ablation in patients with congenital heart disease.

Yang J, Brunnquell M, Liang JJ, Callans DJ, Garcia FC, Lin D, Frankel DS, Kay J, Marchlinski FE, Tzou W, Sauer WH, Liu B, Ruckdeschel ES, Collins K, Santangeli P, Nguyen DT.

J Cardiovasc Electrophysiol. 2019 Sep;30(9):1560-1568. doi: 10.1111/jce.13996. Epub 2019 Jun 11.

PMID: 31111602

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Select item 31115957

 

  1. Arrhythmias in Congenital Heart Disease.

Kline J, Costantini O.

Med Clin North Am. 2019 Sep;103(5):945-956. doi: 10.1016/j.mcna.2019.04.007. Review.

PMID: 31378336

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Select item 31378327

 

  1. Inherited Cardiac Arrhythmias and Channelopathies.

Kline J, Costantini O.

Med Clin North Am. 2019 Sep;103(5):809-820. doi: 10.1016/j.mcna.2019.05.001. Review.

PMID: 31378327

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Select item 31568005

 

  1. Improvement in Dyssynchrony with Pharmacological Ablation of Right-Sided Accessory Pathway-Induced Cardiomyopathy in Infants.

Sekine M, Masutani S, Imamura T, Iwamoto Y, Muraji S, Yoshiba S, Ishido H, Sumitomo N.

Int Heart J. 2019 Sep 27;60(5):1201-1205. doi: 10.1536/ihj.18-723. Epub 2019 Sep 4.

PMID: 31484869 Free Article

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  1. Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case.

Oliveira S, Marques B, Laranjo S, Lopes L.

Pediatr Rep. 2019 Sep 24;11(3):8166. doi: 10.4081/pr.2019.8166. eCollection 2019 Sep 24.

PMID: 31579213 Free PMC Article

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Select item 31568274

 

  1. Trends in Survival after Pediatric In-Hospital Cardiac Arrest in the United States.

Holmberg MJ, Wiberg S, Ross CE, Kleinman M, Hoeyer-Nielsen AK, Donnino MW, Andersen LW; American Heart Association’s Get With The Guidelines®-Resuscitation Investigators.

Circulation. 2019 Sep 23. doi: 10.1161/CIRCULATIONAHA.119.041667. [Epub ahead of print]

PMID: 31542952

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Select item 31545019

 

  1. Neonatal supraventricular tachycardia.

Srinivasan C, Balaji S.

Indian Pacing Electrophysiol J. 2019 Sep 18. pii: S0972-6292(19)30115-9. doi: 10.1016/j.ipej.2019.09.004. [Epub ahead of print]

PMID: 31541680 Free Article

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Select item 31540546

 

  1. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors.

Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN.

Pediatr Cardiol. 2019 Sep 18. doi: 10.1007/s00246-019-02203-2. [Epub ahead of print]

PMID: 31535183

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Select item 31535182

 

  1. Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry.

Crotti L, Spazzolini C, Tester DJ, Ghidoni A, Baruteau AE, Beckmann BM, Behr ER, Bennett JS, Bezzina CR, Bhuiyan ZA, Celiker A, Cerrone M, Dagradi F, De Ferrari GM, Etheridge SP, Fatah M, Garcia-Pavia P, Al-Ghamdi S, Hamilton RM, Al-Hassnan ZN, Horie M, Jimenez-Jaimez J, Kanter RJ, Kaski JP, Kotta MC, Lahrouchi N, Makita N, Norrish G, Odland HH, Ohno S, Papagiannis J, Parati G, Sekarski N, Tveten K, Vatta M, Webster G, Wilde AAM, Wojciak J, George AL, Ackerman MJ, Schwartz PJ.

Eur Heart J. 2019 Sep 14;40(35):2964-2975. doi: 10.1093/eurheartj/ehz311.

PMID: 31170290

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Select item 31145795

 

  1. Cost-Utility of Wearable Cardioverter Defibrillators in Children with Dilated Cardiomyopathy during Medical Optimization: Is it Worth the Wait?

Kim JJ.

Heart Rhythm. 2019 Sep 14. pii: S1547-5271(19)30836-7. doi: 10.1016/j.hrthm.2019.09.015. [Epub ahead of print] No abstract available.

PMID: 31526823

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Select item 31522246

 

  1. Extremely short setting of optimal sensed atrioventricular interval in patients after Fontan procedure with implanted dual-chamber pacemaker.

Miyazaki A, Yoshimura SI, Matsutani H, Miyake M, Negishi J, Yamanaka K, Yamada O, Doi H, Ohuchi H.

Cardiol Young. 2019 Sep 11:1-5. doi: 10.1017/S1047951119002257. [Epub ahead of print]

PMID: 31507257

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  1. The Many Faces of Early Repolarization Syndrome:A Single Center Case-Series.

Voskoboinik A, Hsia H, Moss J, Vedantham V, Tanel RE, Patel A, Wojciak J, Downs N, Scheinman MM.

Heart Rhythm. 2019 Sep 12. pii: S1547-5271(19)30834-3. doi: 10.1016/j.hrthm.2019.09.013. [Epub ahead of print]

PMID: 31521808

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  1. Challenging arrhythmias in a Wolff-Parkinson-White patient: Different physiology and adjacent troubles.

Ali H, Foresti S, Mariucci E, Bronzetti G, De Ambroggi G, Cappato R.

J Cardiovasc Electrophysiol. 2019 Sep 12. doi: 10.1111/jce.14173. [Epub ahead of print] No abstract available.

PMID: 31515886

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Select item 31515865

 

  1. Mothers with long QT syndrome are at increased risk for fetal death: Findings from a multicenter international study.

Cuneo BF, Kaizer AM, Ann Clur S, Swan H, Herberg U, Winbo A, Rydberg A, Haugaa K, Etheridge S, Ackerman MJ, Dagradi F, Killen SAS, Waker-Gussmann A, Benson DW, Wilde AAM, Pan Z, Lam A, Spazzolini C, Horigome H, Schwartz PJ; Fetal LQTS Consortium.

Am J Obstet Gynecol. 2019 Sep 11. pii: S0002-9378(19)31109-3. doi: 10.1016/j.ajog.2019.09.004. [Epub ahead of print]

PMID: 31520628

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  1. Characterization of a novel LQT3 variant with a selective efficacy of mexiletine treatment.

Kim HJ, Kim BG, Park JE, Ki CS, Huh J, Youm JB, Kang JS, Cho H.

Sci Rep. 2019 Sep 10;9(1):12997. doi: 10.1038/s41598-019-49450-0.

PMID: 31506521 Free PMC Article

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Select item 31506459

 

  1. CASQ2 variants in Chinese children with catecholaminergic polymorphic ventricular tachycardia.

Li Q, Guo R, Gao L, Cui L, Zhao Z, Yu X, Yuan Y, Xu X.

Mol Genet Genomic Med. 2019 Sep 3:e949. doi: 10.1002/mgg3.949. [Epub ahead of print]

PMID: 31482657 Free Article

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Select item 31482238

 

  1. [Analysis of 30 cases of inherited cardiac arrhythmia syndrome in children].

Li ZL, Zeng SY, Liang DP, Liu T, Wang SS, Zhang ZW.

Zhonghua Er Ke Za Zhi. 2019 Sep 2;57(9):700-704. doi: 10.3760/cma.j.issn.0578-1310.2019.09.010. Chinese.

PMID: 31530356

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Select item 31571798

 

  1. A Novel and Simple Algorithm Using Surface Electrocardiogram That Localizes Accessory Conduction Pathway in Wolff-Parkinson-White Syndrome in Pediatric Patients.

Li HY, Chang SL, Chuang CH, Lin MC, Lin YJ, Lo LW, Hu YF, Chung FP, Chang YT, Chung CM, Chen SA, Lee PC.

Acta Cardiol Sin. 2019 Sep;35(5):493-500. doi: 10.6515/ACS.201909_35(5).20190312A.

PMID: 31571798 Free PMC Article

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Select item 31301121

 

  1. Exercise-induced syncope and Brugada syndrome.

Batra AS, Watson R, McCanta AC.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):292-294. doi: 10.4103/apc.APC_131_18.

PMID: 31516285 Free PMC Article

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Select item 31516282

 

  1. Fundamentals of Cardiac Mapping.

Ladas TP, Sugrue A, Nan J, Vaidya VR, Padmanabhan D, Venkatachalam KL, Asirvatham SJ.

Card Electrophysiol Clin. 2019 Sep;11(3):433-448. doi: 10.1016/j.ccep.2019.05.005. Review.

PMID: 31400868

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Select item 31400867

 

  1. Anatomic Considerations Relevant to Atrial and Ventricular Arrhythmias.

Nan J, Sugrue A, Ladas TP, Mehra N, Asirvatham SJ.

Card Electrophysiol Clin. 2019 Sep;11(3):421-432. doi: 10.1016/j.ccep.2019.04.003. Review.

PMID: 31400867

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Select item 31451130

 

  1. Variable Presentations and Ablation Sites for Manifest Nodoventricular/Nodofascicular Fibers.

Nazer B, Walters TE, Dewland TA, Naniwadekar A, Koruth JS, Najeeb Osman M, Intini A, Chen M, Biermann J, Steinfurt J, Kalman JM, Tanel RE, Lee BK, Badhwar N, Gerstenfeld EP, Scheinman MM.

Circ Arrhythm Electrophysiol. 2019 Sep;12(9):e007337. doi: 10.1161/CIRCEP.119.007337. Epub 2019 Sep 11.

PMID: 31505948

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  1. Long-term results of atrial maze surgery in patients with congenital heart disease.

Gonzalez Corcia MC, Walsh EP, Emani S.

Europace. 2019 Sep 1;21(9):1345-1352. doi: 10.1093/europace/euz056.

PMID: 31004150

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  1. A 45-year experience with the Fontan procedure: tachyarrhythmia, an important sign for adverse outcome.

Rijnberg FM, Blom NA, Sojak V, Bruggemans EF, Kuipers IM, Rammeloo LAJ, Jongbloed MRM, Bouma BJ, Hazekamp MG.

Interact Cardiovasc Thorac Surg. 2019 Sep 1;29(3):461-468. doi: 10.1093/icvts/ivz111.

PMID: 31038168

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  1. Clinical efficacy of open-irrigated electrode cooled with half-normal saline for initially failed radiofrequency ablation of idiopathic outflow tract ventricular arrhythmias.

Chung FP, Vicera JJB, Lin YJ, Chang SL, Lo LW, Hu YF, Lin CY, Tuan TC, Chao TF, Liao JN, Chang TY, Salim S, Liu CM, Chuang CM, Chen CC, Chin CG, Wu CI, Chou CY, Chen SA.

J Cardiovasc Electrophysiol. 2019 Sep;30(9):1508-1516. doi: 10.1111/jce.14057. Epub 2019 Jul 18.

PMID: 31257650

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  1. The Effect of Left Cardiac Sympathetic Denervation on Exercise in Patients With Long QT Syndrome.

Anderson HN, Bos JM, Rohatgi RK, Ackerman MJ.

JACC Clin Electrophysiol. 2019 Sep;5(9):1084-1090. doi: 10.1016/j.jacep.2019.06.008.

PMID: 31537339

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Select item 31301000

 

  1. Different habitus but similar electrocardiogram: Cardiac repolarization parameters in children – Comparison of elite athletes to obese children.

Paech C, Moser J, Dähnert I, Wagner F, Gebauer RA, Kirsten T, Vogel M, Kiess W, Körner A, Wolfarth B, Wüstenfeld J.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):201-205. doi: 10.4103/apc.APC_90_18.

PMID: 31516275 Free PMC Article

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ACHD Interventional Cardiology Featured Articles

CHD Interventions September 2019

Interventional Cardiology Reviews of September 2019 Manuscripts

Drug-Eluting Stents Compared With Bare Metal Stents for Stenting the Ductus Arteriosus in Infants With Ductal-Dependent Pulmonary Blood Flow.

Aggarwal V, Dhillon GS, Penny DJ, Gowda ST, Qureshi AM.

Am J Cardiol. 2019 Sep 15;124(6):952-959. doi: 10.1016/j.amjcard.2019.06.014. Epub 2019 Jun 26.

PMID: 31350000

 Take-Home Points:

  • Drug eluting coronary artery stents (DES) have been theorized to have a lower incidence of neo-intimal proliferation (compared with bare metal stents) when implanted in the ductus arteriosus.
  • DES were found to have significantly less luminal loss and fewer unplanned interventions when compared to BMS.

 Commentary from Dr. Konstantin Averin (Edmonton, Canada), catheterization section editor of Pediatric Cardiology Journal Watch:  Stenting of the ductus arteriosus (DA) is rapidly emerging as an equivalent (or superior) option for augmenting pulmonary blood flow in infants with ductal-dependent pulmonary blood flow (PBF). Drug eluting coronary artery stents (DES) have been theorized to have a lower incidence of neo-intimal proliferation but data comparing them to bare metal stents (BMS) in this patient population are lacking. The authors sought to compare the safety and efficacy of DES to BMS in neonates undergoing DA stenting for ductal-dependent PBF.

Over a 14 year period (2004-2018) 71 infants with confluent central pulmonary arteries underwent ductal stenting for ductal-dependent PBF (46 BMS and 25 DES) with stent selection being uniform during the study period. The baseline characteristics of the cohort as a whole were unremarkable and were similar between the 2 groups (BMS v DES). Freedom from ≥ 50% luminal loss was significantly higher in the DES group (see Kaplan Meier curve below) with the odds ratio for a 50% loss in luminal diameter (as assessed via a subsequent angiographic evaluation) being 1.6 (95% CI 1.2-2.3) for BMS v DES. Sixteen infants (23%) underwent unplanned re-interventions to treat cyanosis, with a significantly higher percentage in the BMS group (28%) compared to the DES group (12%), p=0.02.

There was no mortality difference between the groups. Given concerns about serum drug levels in infants with DES, the authors compared rates of infection between the 2 groups and found the rate of bacterial infection to be higher in the DES group (8% v 2%) but this did not reach statistical significance.

The authors conclude that luminal loss was significantly less and unplanned interventions less common in patients with DES compared to BMS. While the authors did not measure serum drug levels, even if they had been elevated there do not appear to have been significant clinical sequela related to this (consistent with prior reports). Intuition would suggest that anti-proliferative agents would mitigate neo-intimal proliferation of ductal tissue and this report begins to lend credence to that theory. Given the data presented in this report, providers should strongly consider use of DES (vs BMS) for ductal stenting.

 

 

 

CHD Interventions Sept 2019

  1. Multimodality imaging for diagnosis and procedural planning for a ruptured sinus of Valsalva aneurysm.

Kern MC, Janardhanan R, Kelly T, Fox KA, Klewer SE, Seckeler MD.

J Cardiovasc Comput Tomogr. 2019 Sep 29. pii: S1934-5925(19)30450-2. doi: 10.1016/j.jcct.2019.09.018. [Epub ahead of print] No abstract available.

PMID: 31587967

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  1. Melody valve in aortic position to facilitate mechanical circulatory support as a bridge to cardiac transplantation.

Khambadkone S, Burch M, Fenton M, Derrick G, Thiruchelvam T, Karimova A, Bohuta L, Hsia TY.

Ann Thorac Surg. 2019 Sep 27. pii: S0003-4975(19)31434-1. doi: 10.1016/j.athoracsur.2019.08.044. [Epub ahead of print]

PMID: 31568748

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  1. An uncommon case of acute non-traumatic paraplegia: endovascular management of an occluding thrombus in the thoracic aorta 32 years after open surgery for aortic coarctation.

Schmiady MO, Greutmann M, Pfiffner R, Rancic Z.

Eur Heart J. 2019 Sep 21;40(36):3065. doi: 10.1093/eurheartj/ehz053. No abstract available.

PMID: 30805620

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Select item 31326119

 

  1. Dimensional Accuracy and Clinical Value of 3D Printed Models in Congenital Heart Disease: A Systematic Review and Meta-Analysis.

Lau IWW, Sun Z.

J Clin Med. 2019 Sep 18;8(9). pii: E1483. doi: 10.3390/jcm8091483. Review.

PMID: 31540421 Free Article

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Select item 31532867

 

  1. Clinical characteristics in patients with rest angina and hypoplastic right coronary artery.

Sueda S, Kohno H.

Heart Vessels. 2019 Sep 16. doi: 10.1007/s00380-019-01507-w. [Epub ahead of print]

PMID: 31529177

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Select item 31158496

 

  1. Biodegradable atrial septal defect occluders: A current review.

Shi D, Kang Y, Zhang G, Gao C, Lu W, Zou H, Jiang H.

Acta Biomater. 2019 Sep 15;96:68-80. doi: 10.1016/j.actbio.2019.05.073. Epub 2019 May 31. Review.

PMID: 31158496

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Select item 31327487

 

  1. Immediate and short-term effects of transcatheter device closure of large atrial septal defect in senior people.

Wang S, Pan J, Xiao B, Tang Y, Lan J, Zheng X, Yang C, Xu D, Zhang J.

Congenit Heart Dis. 2019 Sep 12. doi: 10.1111/chd.12844. [Epub ahead of print]

PMID: 31513356

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Select item 31513339

 

  1. Transcatheter treatment of acquired coronary sinus ostium atresia in a child with complex congenital heart disease.

Kops SA, Pangburn S, Barber BJ, Seckeler MD.

Catheter Cardiovasc Interv. 2019 Sep 5. doi: 10.1002/ccd.28489. [Epub ahead of print]

PMID: 31486566

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Select item 31348032

 

  1. What is the Significance of Elevated Troponin I in Children and Adolescents? A Diagnostic Approach.

Yoldaş T, Örün UA.

Pediatr Cardiol. 2019 Sep 4. doi: 10.1007/s00246-019-02198-w. [Epub ahead of print]

PMID: 31485699

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Select item 31492537

 

  1. Indications and results for hybrid interventions in patients with congenital heart disease.

Kalfa D, Torres AJ.

Arch Cardiovasc Dis. 2019 Sep 3. pii: S1875-2136(19)30136-6. doi: 10.1016/j.acvd.2019.06.006. [Epub ahead of print] Review.

PMID: 31492537

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Select item 31564989

 

  1. Very long-term outcomes of transcatheter secundum atrial septal defect closure using intracardiac echocardiography without balloon sizing.

Rigatelli G, Nghia NT, Zuin M, Conte L, D’Elia K, Nanjundappa A.

Clin Radiol. 2019 Sep;74(9):732.e17-732.e22. doi: 10.1016/j.crad.2019.05.017. Epub 2019 Jun 20.

PMID: 31230756

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Select item 30315601

 

  1. Intermediate outcomes of transcatheter pulmonary valve replacement with the Edwards Sapien 3 valve – German experience.

Lehner A, Dashkalova T, Ulrich S, Fernandez Rodriguez S, Mandilaras G, Jakob A, Dalla-Pozza R, Fischer M, Schneider H, Tarusinov G, Kampmann C, Hofbeck M, Dähnert I, Kanaan M, Haas NA.

Expert Rev Med Devices. 2019 Sep;16(9):829-834. doi: 10.1080/17434440.2019.1653180. Epub 2019 Aug 30.

PMID: 31432698

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  1. Coronary Confusion? An Unexpected Congenital Anomaly in a Patient with an Ostium Secundum Atrial Septal Defect.

Hang D, Miller RE, Rokkas CK, Pagel PS.

J Cardiothorac Vasc Anesth. 2019 Sep;33(9):2600-2603. doi: 10.1053/j.jvca.2019.03.028. Epub 2019 Mar 16. No abstract available.

PMID: 31072707

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  1. Commentary: Stem cell therapy for single-ventricle congenital heart disease: Exciting, but a long way to go.

Miller JR, Eghtesady P.

J Thorac Cardiovasc Surg. 2019 Sep;158(3):851-852. doi: 10.1016/j.jtcvs.2019.05.041. Epub 2019 May 30. No abstract available.

PMID: 31277816

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  1. A Novel and Simple Percutaneous Technique to Treat a Complex Pseudoaneurysm of Post-Aortic Coarctation Patch Aortoplasty.

Pascual-Tejerina V, Sánchez-Recalde Á, Gutiérrez-Larraya F, Zamorano JL.

JACC Cardiovasc Interv. 2019 Sep 23;12(18):e159-e160. doi: 10.1016/j.jcin.2019.06.016. Epub 2019 Aug 28. No abstract available.

PMID: 31473233

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Select item 31549187

 

  1. Role of 3D transesophageal echocardiography in transcatheter closure of atrial septal aneurysms.

Taha F, Elshedoudy S.

Echocardiography. 2019 Sep 21. doi: 10.1111/echo.14482. [Epub ahead of print]

PMID: 31541598

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Select item 31548437

 

  1. Development of a Ductal Aneurysm in a Patient with Williams Syndrome, and Subsequent Interventional Closure.

van den Berg G, Helbing WA, van Beynum I, Krasemann TB.

Pediatr Cardiol. 2019 Sep 18. doi: 10.1007/s00246-019-02211-2. [Epub ahead of print]

PMID: 31535182

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  1. Drug-Eluting Stents Compared With Bare Metal Stents for Stenting the Ductus Arteriosus in Infants With Ductal-Dependent Pulmonary Blood Flow.

Aggarwal V, Dhillon GS, Penny DJ, Gowda ST, Qureshi AM.

Am J Cardiol. 2019 Sep 15;124(6):952-959. doi: 10.1016/j.amjcard.2019.06.014. Epub 2019 Jun 26.

PMID: 31350000

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  1. “Treat-to-close”: Non-repairable ASD-PAH in the adult: Results from the North American ASD-PAH (NAAP) Multicenter Registry.

Bradley EA, Ammash N, Martinez SC, Chin K, Hebson C, Singh HS, Aboulhosn J, Grewal J, Billadello J, Chakinala MM, Daniels CJ, Zaidi AN.

Int J Cardiol. 2019 Sep 15;291:127-133. doi: 10.1016/j.ijcard.2019.03.056. Epub 2019 Apr 17.

PMID: 31031077

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  1. Elective left pulmonary artery embolisation for pulmonary arteriovenous malformations secondary to cavopulmonary anastomoses not responsive to heart transplantation: a case report.

Bebawy CM, Gordon BM, Bock MJ.

Cardiol Young. 2019 Sep 13:1-3. doi: 10.1017/S1047951119002130. [Epub ahead of print]

PMID: 31514756

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  1. Hammock effect and complete cusp prolapse: Rare mechanisms of Melody valve failure demonstrated by intracardiac echocardiography.

Jhaveri S, Prieto L, Suntharos P.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):342-344. doi: 10.4103/apc.APC_143_18.

PMID: 31516300 Free PMC Article

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  1. Transcatheter closure of a rare coronary artery fistula using a modified mother-child technique.

Perez-Brandão C, Fiarresga A, Sousa L, Martins JD.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):329-332. doi: 10.4103/apc.APC_175_18.

PMID: 31516296 Free PMC Article

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  1. Closure of right pulmonary artery to left atrium fistula by duct occluder device.

Hussain I, KhawajaKhail R, Khattak K, Irfan M, Gul AM.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):321-324. doi: 10.4103/apc.APC_155_18.

PMID: 31516294 Free PMC Article

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  1. Temporary bronchial stenting for airway compression in the interstage palliation of functional single ventricle.

Barnes JH, Boesch RP, Balakrishnan K, Said SM, Van Dorn CS.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):308-311. doi: 10.4103/apc.APC_94_18.

PMID: 31516290 Free PMC Article

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  1. Percutaneous closure of patent ductus arteriosus with the Nit-Occlud® patent ductus arteriosus device in 268 consecutive cases.

Maksymenko AV, Kuzmenko YL, Dovhaliuk AA, Motrechko OO, Herrmann FE, Haas NA, Lehner A.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):206-211. doi: 10.4103/apc.APC_151_18.

PMID: 31516276 Free PMC Article

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  1. Intra-aortic Balloon Pump As a Bridge to Heart Transplant After Non-ST-Segment-Elevation Myocardial Infarction in Palliated Hypoplastic Left Heart Syndrome.

Osula D, Farris GR, Chatterjee A, Law MA, Cribbs MG.

Circ Heart Fail. 2019 Sep;12(9):e006130. doi: 10.1161/CIRCHEARTFAILURE.119.006130. Epub 2019 Sep 2. No abstract available.

PMID: 31474118

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  1. The standing of percutaneous pulmonary valve implantation compared to surgery in a non-preselected cohort with dysfunctional right ventricular outflow tract – Reasons for failure and contraindications.

Haas NA, Vcasna R, Laser KT, Blanz U, Herrmann FE, Jakob A, Fischer M, Kanaan M, Lehner A.

J Cardiol. 2019 Sep;74(3):217-222. doi: 10.1016/j.jjcc.2019.03.021. Epub 2019 Jun 21.

PMID: 31230902

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Select item 31113702

 

  1. The risk of infective endocarditis following interventional pulmonary valve implantation: A meta-analysis.

Lehner A, Haas NA, Dietl M, Jakob A, Schulze-Neick I, Dalla Pozza R, Rodriguez SF, Fischer M.

J Cardiol. 2019 Sep;74(3):197-205. doi: 10.1016/j.jjcc.2019.04.007. Epub 2019 May 18. Review.

PMID: 31113702

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  1. The black swan: Unique coronary arterial anatomy observed in a patient with transposition.

Michalak KW, Wernovsky G, Moll M, Anderson RH.

J Thorac Cardiovasc Surg. 2019 Sep;158(3):e107-e109. doi: 10.1016/j.jtcvs.2019.03.087. Epub 2019 Apr 4. No abstract available.

PMID: 31036358

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  1. Characteristics and transcatheter closure of patent ductus arteriosus in patients living at moderate to high altitude in Eastern Anatolia.

Epçaçan S, Bulut MO, Kaya Y, Yücel IK, Çakır Ç, Şişli E, Ceylan Y, Çelebi A.

Turk Kardiyol Dern Ars. 2019 Sep;47(6):431-439. doi: 10.5543/tkda.2019.20805.

PMID: 31483299 Free Article

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  1. Outcomes of the Non-fenestrated Fontan Procedure at High Altitude.

Palacios-Macedo A, Díliz-Nava H, Tamariz-Cruz O, García-Benítez L, Pérez-Juárez F, Araujo-Martínez A, Mier-Martínez M, Corona-Villalobos C, Castañuela V, March A, López-Terrazas J, Cabrera AG.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):590-596. doi: 10.1177/2150135119862607.

PMID: 31496420

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  1. Rescue Cardiac Surgeries After Pediatric Catheter-Based Interventions: A Ten-Year Retrospective Study.

Menaissy Y, Alkady H, El-Saiedi S.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):539-542. doi: 10.1177/2150135119852318.

PMID: 31496402

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  1. Retrograde transcatheter closure of anterior mitral valve leaflet perforation.

Sengun B, Yıldırım I, Yıldız Ö, Çeliker A.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):312-314. doi: 10.4103/apc.APC_162_18.

PMID: 31516291 Free PMC Article

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ACHD Surgery

Congenital Heart Surgery Reviews of September 2019 Manuscripts

 

CHD Surgery Sept 2019

Right Ventricle Dependent Coronary Circulation: Location of Obstruction is Associated with Survival.

Spigel Z, Qureshi AM, Morris SA, Mery CM, Sexson-Tejtel SK, Zea-Vera R, Binsalamah Z, Imamura M, Heinle J, Adachi I.

Ann Thorac Surg. 2019 Sep 30. pii: S0003-4975(19)31457-2. doi: 10.1016/j.athoracsur.2019.08.066. [Epub ahead of print]

PMID: 31580859

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  1. ANTI-PIG ANTIBODY IN INFANTS: CAN A GENETICALLY-ENGINEERED PIG HEART BRIDGE TO ALLOTRANSPLANTATION?

Li Q, Hara H, Banks CA, Yamamoto T, Ayares D, Mauchley DC, Dabal RJ, Padilla L, Carlo WF, Rhodes LA, Cooper DKC, Cleveland DC.

Ann Thorac Surg. 2019 Sep 30. pii: S0003-4975(19)31452-3. doi: 10.1016/j.athoracsur.2019.08.061. [Epub ahead of print]

PMID: 31580857

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Select item 31568572

 

  1. Cardiac surgical missions: what works, what does not, where we need to go from here.

Polivenok I, Gelatt M, Cardarelli M.

Curr Opin Cardiol. 2019 Sep 30. doi: 10.1097/HCO.0000000000000691. [Epub ahead of print]

PMID: 31574003

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Select item 31570783

 

  1. Reoperation after isolated subaortic membrane resection.

Binsalamah ZM, Spigel ZA, Zhu H, Kim MB, Chacon-Portillo MA, Adachi I, Imamura M, Mery CM, Mckenzie ED, Fraser CD, Heinle JS.

Cardiol Young. 2019 Sep 26:1-6. doi: 10.1017/S1047951119002336. [Epub ahead of print]

PMID: 31554530

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Select item 31554525

 

  1. Avoidance of malignant arrhythmia caused by displacement of the right coronary artery ostium in surgical correction of supravalvular aortic stenosis.

Peng B, Wang Q.

J Int Med Res. 2019 Sep 26:300060518818021. doi: 10.1177/0300060518818021. [Epub ahead of print] No abstract available.

PMID: 31558080

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Select item 31568238

 

  1. Percutaneous Endoscopic Gastrostomy After Cardiothoracic Surgery in Children Less Than 2 Months Old: An Assessment of Long-Term Malnutrition Status and Gastrostomy Outcomes.

Sochet AA, Grindy AK, Son S, Barrie EK, Hickok RL, Nakagawa TA, Wilsey MJ.

Pediatr Crit Care Med. 2019 Sep 26. doi: 10.1097/PCC.0000000000002129. [Epub ahead of print]

PMID: 31568238

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Select item 31567409

 

  1. End-Stage Liver Disease Models and Outcomes in Pediatric Patients Supported With Short-Term Continuous-Flow Ventricular Assist Devices.

Malik G, Pidborochynski T, Buchholz H, Freed DH, Al-Aklabi M, Bozso SJ, Choudhry S, Anand V, Holinski P, Conway J.

ASAIO J. 2019 Sep 25. doi: 10.1097/MAT.0000000000001078. [Epub ahead of print]

PMID: 31567409

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Select item 31563274

 

  1. 2-Year Outcomes After Complete or Staged Procedure for Tetralogy of Fallot in Neonates.

Savla JJ, Faerber JA, Huang YV, Zaoutis T, Goldmuntz E, Kawut SM, Mercer-Rosa L.

J Am Coll Cardiol. 2019 Sep 24;74(12):1570-1579. doi: 10.1016/j.jacc.2019.05.057.

PMID: 31537267

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Select item 31561958

 

  1. Diagnosing infection after infant open heart surgery: role of procalcitonin.

Fakhri D, Marwali EM, Budiwardhana N, Roebiono PS, Rahajoe AU, Caesario M.

Asian Cardiovasc Thorac Ann. 2019 Sep 23:218492319879529. doi: 10.1177/0218492319879529. [Epub ahead of print] No abstract available.

PMID: 31547669

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Select item 31548181

 

  1. Risk stratification models for congenital heart surgery in children: Comparative single-center study.

Bobillo-Perez S, Sanchez-de-Toledo J, Segura S, Girona-Alarcon M, Mele M, Sole-Ribalta A, Cañizo Vazquez D, Jordan I, Cambra FJ.

Congenit Heart Dis. 2019 Sep 23. doi: 10.1111/chd.12846. [Epub ahead of print]

PMID: 31545015

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Select item 31549332

 

  1. Reabsorbable Pins can Reinforce an Early Sternal Stability After Median Sternotomy in Young Children with Congenital Heart Disease.

Fan C, Tang M, Wu S, Yuan S, Borovjagin AV, Yang J.

Pediatr Cardiol. 2019 Sep 23. doi: 10.1007/s00246-019-02212-1. [Epub ahead of print]

PMID: 31549187

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Select item 31549230

 

  1. Impact of the 2016 revision of US pediatric heart allocation policy on waitlist characteristics and outcomes.

Magnetta DA, Godown J, West S, Zinn M, Rose-Felker K, Miller S, Feingold B.

Am J Transplant. 2019 Sep 22. doi: 10.1111/ajt.15567. [Epub ahead of print]

PMID: 31544351

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Select item 30805620

 

  1. Surgical Treatment of Infective Endocarditis in Pulmonary Position-15 Years Single Centre Experience.

Liekiene D, Bezuska L, Semeniene P, Cypiene R, Lebetkevicius V, Tarutis V, Barysiene J, Rucinskas K, Sirvydis V.

Medicina (Kaunas). 2019 Sep 19;55(9). pii: E608. doi: 10.3390/medicina55090608.

PMID: 31546957 Free Article

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Select item 31537853

 

  1. Preoperative Physiology, Imaging, and Management of Coarctation of Aorta in Children.

Ganigara M, Doshi A, Naimi I, Mahadevaiah GP, Buddhe S, Chikkabyrappa SM.

Semin Cardiothorac Vasc Anesth. 2019 Sep 19:1089253219873004. doi: 10.1177/1089253219873004. [Epub ahead of print]

PMID: 31535945

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Select item 31541634

 

  1. A case series of left main coronary artery ostial atresia and a review of the literature.

Alsalehi M, Jeewa A, Wan A, Contreras J, Yoo SJ, Laks JA.

Congenit Heart Dis. 2019 Sep 18. doi: 10.1111/chd.12842. [Epub ahead of print] Review.

PMID: 31532081

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Select item 31534214

 

  1. Left ventricular dysfunction postsurgical patent ductus arteriosus ligation in children: predictor factors analysis.

Abdel-Bary M, Abdel-Baseer KA, Abdel-Latif AF, Abdel-Naser MA, Nafie M, Eisa KM.

J Cardiothorac Surg. 2019 Sep 18;14(1):168. doi: 10.1186/s13019-019-0990-z.

PMID: 31533759 Free PMC Article

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Select item 31540421

 

  1. Neurologic Outcomes after Heart Surgery.

Fang A, Allen KY, Marino BS, Brady KM.

Paediatr Anaesth. 2019 Sep 18. doi: 10.1111/pan.13744. [Epub ahead of print]

PMID: 31532867

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Select item 31535184

 

  1. A new era in pediatric heart allocation: Keeping our house in order.

Mao CY, Mahle WT.

Am J Transplant. 2019 Sep 17. doi: 10.1111/ajt.15596. [Epub ahead of print]

PMID: 31529765

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Select item 31526142

 

  1. Evaluation of an updated sedation protocol to reduce benzodiazepines in a pediatric intensive care unit.

Michel J, Hofbeck M, Peper AK, Kumpf M, Neunhoeffer F.

Curr Med Res Opin. 2019 Sep 17:1-6. doi: 10.1080/03007995.2019.1663689. [Epub ahead of print]

PMID: 31526142

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Select item 31529991

 

  1. Use of mechanical valve prostheses in adults with tetralogy of Fallot.

Egbe AC, Miranda WR, Ammash NM, Said SM, Missula VR, Abdelsamid MF, Kothapalli S, Connolly HM.

Int J Cardiol. 2019 Sep 15;291:45-49. doi: 10.1016/j.ijcard.2019.02.028. Epub 2019 Feb 16.

PMID: 30803889

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Select item 30772012

 

  1. Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study.

Padalino MA, Franchetti N, Sarris GE, Hazekamp M, Carrel T, Frigiola A, Horer J, Roussin R, Cleuziou J, Meyns B, Fragata J, Telles H, Polimenakos AC, Francois K, Veshti A, Salminen J, Rocafort AG, Nosal M, Vedovelli L, Protopapas E, Tumbarello R, Merola A, Pegoraro C, Motta R, Boccuzzo G, Sojak V, Rito ML, Caldaroni F, Corrado D, Basso C, Stellin G.

Int J Cardiol. 2019 Sep 15;291:189-193. doi: 10.1016/j.ijcard.2019.02.007. Epub 2019 Feb 10.

PMID: 30772012 Free Article

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Select item 31178488

 

  1. Early assessment of cardiac troponin I predicts the postoperative cardiac status and clinical course after congenital heart disease surgery.

Kojima T, Toda K, Oyanagi T, Yoshiba S, Kobayashi T, Sumitomo N.

Heart Vessels. 2019 Sep 14. doi: 10.1007/s00380-019-01497-9. [Epub ahead of print]

PMID: 31522246

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Select item 31515672

 

  1. Glutathione Blood Concentrations: A Biomarker of Oxidative Damage Protection during Cardiopulmonary Bypass in Children.

Satriano A, Franchini S, Lapergola G, Pluchinotta F, Anastasia L, Baryshnikova E, Livolti G, Gazzolo D.

Diagnostics (Basel). 2019 Sep 13;9(3). pii: E118. doi: 10.3390/diagnostics9030118.

PMID: 31540197 Free Article

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Select item 31514562

 

  1. Effects of Balanced Ultrafiltration During Extracorporeal Circulation for Children with Congenital Heart Disease on Postoperative Serum Inflammatory Response.

Chen F, You Y, Ding P, Wu K, Mo X.

Fetal Pediatr Pathol. 2019 Sep 13:1-8. doi: 10.1080/15513815.2019.1661050. [Epub ahead of print]

PMID: 31514562

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Select item 31520462

 

  1. Efficacy and safety of dacron patch in surgical treatment of congenital disease by echocardiography.

Deng M, Yang Q.

J Infect Public Health. 2019 Sep 13. pii: S1876-0341(19)30275-8. doi: 10.1016/j.jiph.2019.08.009. [Epub ahead of print]

PMID: 31526640 Free Article

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Select item 31521596

 

  1. Arterial switch operation for transposition of the great arteries: A single-centre 32-year experience.

Vida VL, Zanotto L, Zanotto L, Triglia LT, Bellanti E, Castaldi B, Padalino MA, Gasperetti A, Battista F, Varnier M, Stellin G.

J Card Surg. 2019 Sep 11. doi: 10.1111/jocs.14045. [Epub ahead of print]

PMID: 31508848

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Select item 31521397

 

  1. What are the important morbidities associated with paediatric cardiac surgery? A mixed methods study.

Brown KL, Pagel C, Ridout D, Wray J, Anderson D, Barron DJ, Cassidy J, Davis P, Hudson E, Jones A, Mclean A, Morris S, Rodrigues W, Sheehan K, Stoica S, Tibby SM, Witter T, Tsang VT; Cardiac Impact Study Group.

BMJ Open. 2019 Sep 9;9(9):e028533. doi: 10.1136/bmjopen-2018-028533.

PMID: 31501104 Free PMC Article

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Select item 31501090

 

  1. Incidence of ESKD and Mortality among Children with Congenital Heart Disease after Cardiac Surgery.

Parikh CR, Greenberg JH, McArthur E, Thiessen-Philbrook H, Everett AD, Wald R, Zappitelli M, Chanchlani R, Garg AX.

Clin J Am Soc Nephrol. 2019 Sep 9. pii: CJN.00690119. doi: 10.2215/CJN.00690119. [Epub ahead of print]

PMID: 31501090

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Select item 31498562

 

  1. Effect of two different colloid priming strategies in infants weighing less than 5 kg undergoing on-pump cardiac surgeries.

Zhou C, Tong Y, Feng Z, Cui Y, Zhao M, Hu J, Liu K, Zhao J, Liu J.

Artif Organs. 2019 Sep 8. doi: 10.1111/aor.13561. [Epub ahead of print]

PMID: 31494945

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Select item 31511192

 

  1. Effect of Trisomy 21 on Postoperative Length of Stay and Non-cardiac Surgery After Complete Repair of Tetralogy of Fallot.

Purifoy ET, Spray BJ, Riley JS, Prodhan P, Bolin EH.

Pediatr Cardiol. 2019 Sep 7. doi: 10.1007/s00246-019-02196-y. [Epub ahead of print]

PMID: 31494702

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Select item 31489832

 

  1. 32 year follow up of patients following atrial redirection surgery for transposition of the great arteries.

Morrison ML, Grant B, McCrossan BA, Sands AJ, Owens CG, Spence MS, Casey FA, Craig BG, Lockhart CJ.

Congenit Heart Dis. 2019 Sep 6. doi: 10.1111/chd.12822. [Epub ahead of print]

PMID: 31489769

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Select item 31492700

 

  1. Pulmonary artery size is associated with functional clinical status in the Fontan circulation.

Ridderbos FS, Bonenkamp BE, Meyer SL, Eshuis G, Ebels T, van Melle JP, Willems TP, Berger RMF.

Heart. 2019 Sep 6. pii: heartjnl-2019-314972. doi: 10.1136/heartjnl-2019-314972. [Epub ahead of print]

PMID: 31492699

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Select item 31517771

 

  1. Giant aneurysm of the right atrial appendage repaired by minimally invasive approach.

Hiraoka A, Tachibana H, Yoshitaka H, Sakaguchi T.

J Card Surg. 2019 Sep 3. doi: 10.1111/jocs.14206. [Epub ahead of print]

PMID: 31478249

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Select item 31582201

 

  1. Case 4/2019 – 26-Year-Old Man with Congenital Chagas Disease and Heart Transplantation.

Pinesi HT, Strabelli TMV, Aiello VD.

Arq Bras Cardiol. 2019 Sep 2;113(2):286-293. doi: 10.5935/abc.20190162. English, Portuguese. No abstract available.

PMID: 31483025 Free Article

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Select item 31483331

 

  1. Long-Term Survival of Patients With Coarctation Repaired During Infancy (from the Pediatric Cardiac Care Consortium).

Oster ME, McCracken C, Kiener A, Aylward B, Cory M, Hunting J, Kochilas LK.

Am J Cardiol. 2019 Sep 1;124(5):795-802. doi: 10.1016/j.amjcard.2019.05.047. Epub 2019 Jun 6.

PMID: 31272703

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Select item 31272701

 

  1. Preoperative adrenal insufficiency in a neonate with congenital heart disease surgery.

Kadam SV, Tailor KB, Joshi VH, Rao SG.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):351-353. doi: 10.4103/apc.APC_108_18. No abstract available.

PMID: 31516305 Free PMC Article

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Select item 31516289

 

  1. Severe thrombocytopenia in tetralogy of Fallot patients: A contraindication for corrective surgery?

Patil S, Relan J, Hote M, Kothari SS.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):305-307. doi: 10.4103/apc.APC_71_18.

PMID: 31516289 Free PMC Article

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Select item 31516284

 

  1. Surgical repair for common arterial trunk with pulmonary dominance, hypoplasia of ascending aorta, and interrupted aortic arch.

Talwar S, Siddharth B, Gupta SK, Bhoje A, Choudhary SK.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):287-291. doi: 10.4103/apc.APC_147_18.

PMID: 31516284 Free PMC Article

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Select item 31516283

 

  1. Minimally Invasive Surgical Options with Valvular Heart Disease.

Hartjes TM, Lester D.

Crit Care Nurs Clin North Am. 2019 Sep;31(3):257-265. doi: 10.1016/j.cnc.2019.04.002. Epub 2019 Jun 6. Review.

PMID: 31351549

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Select item 31365379

 

  1. A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data†.

Boethig D, Horke A, Hazekamp M, Meyns B, Rega F, Van Puyvelde J, Hübler M, Schmiady M, Ciubotaru A, Stellin G, Padalino M, Tsang V, Jashari R, Bobylev D, Tudorache I, Cebotari S, Haverich A, Sarikouch S.

Eur J Cardiothorac Surg. 2019 Sep 1;56(3):503-509. doi: 10.1093/ejcts/ezz054.

PMID: 30879050 Free PMC Article

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Select item 31297625

 

  1. Risk factors of mortality and recoarctation after coarctation repair in infancy.

Lehnert A, Villemain O, Gaudin R, Méot M, Raisky O, Bonnet D.

Interact Cardiovasc Thorac Surg. 2019 Sep 1;29(3):469-475. doi: 10.1093/icvts/ivz117.

PMID: 31089681

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Select item 31374590

 

  1. OpHeart commentary: Three-dimensional printing for surgical planning in complex congenital heart disease.

Garcia A.

J Card Surg. 2019 Sep;34(9):753. doi: 10.1111/jocs.14178. Epub 2019 Aug 2. No abstract available.

PMID: 31374590

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Select item 30928109

 

  1. Perfusion Methods and Modifications to the Cardiopulmonary Bypass Circuit for Midline Unifocalization Procedures.

Margetson TD, Sleasman J, Kollmann S, McCarthy PJ, Jahadi O, Sheff D, Shuttleworth P, Mainwaring RD, Hanley FL.

J Extra Corpor Technol. 2019 Sep;51(3):147-152.

PMID: 31548736

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Select item 30612882

 

  1. Survival analysis of extracorporeal membrane oxygenation in neonatal and pediatric patients – A nationwide cohort study.

Hsu J, Chang CH, Chiang LT, Caffrey JL, Lin JW, Chen YS.

J Formos Med Assoc. 2019 Sep;118(9):1339-1346. doi: 10.1016/j.jfma.2018.12.008. Epub 2019 Jan 4.

PMID: 30612882 Free Article

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Select item 31495407

 

  1. Early outcomes for low-risk pediatric heart transplant recipients and steroid avoidance: A multicenter cohort study (Clinical Trials in Organ Transplantation in Children – CTOTC-04).

Lamour JM, Mason KL, Hsu DT, Feingold B, Blume ED, Canter CE, Dipchand AI, Shaddy RE, Mahle WT, Zuckerman WA, Bentlejewski C, Armstrong BD, Morrison Y, Diop H, Iklé DN, Odim J, Zeevi A, Webber SA; CTOTC-04 investigators.

J Heart Lung Transplant. 2019 Sep;38(9):972-981. doi: 10.1016/j.healun.2019.06.006. Epub 2019 Jun 20.

PMID: 31324444

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Select item 31317587

 

  1. Hirschsprung disease and Down syndrome: From the reappraisal of risk factors to the impact of surgery.

Pini Prato A, Arnoldi R, Sgrò A, Felici E, Racca F, Nozza P, Mariani N, Mosconi M, Mazzola C, Mattioli G.

J Pediatr Surg. 2019 Sep;54(9):1838-1842. doi: 10.1016/j.jpedsurg.2019.01.053. Epub 2019 Feb 12.

PMID: 30814038

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Select item 30635129

 

  1. Features associated with myocardial ischemia in anomalous aortic origin of a coronary artery: A Congenital Heart Surgeons’ Society study.

Jegatheeswaran A, Devlin PJ, McCrindle BW, Williams WG, Jacobs ML, Blackstone EH, DeCampli WM, Caldarone CA, Gaynor JW, Kirklin JK, Lorber RO, Mery CM, St Louis JD, Molossi S, Brothers JA.

J Thorac Cardiovasc Surg. 2019 Sep;158(3):822-834.e3. doi: 10.1016/j.jtcvs.2019.02.122. Epub 2019 Mar 28.

PMID: 31235351

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Select item 31005300

 

  1. Transcriptome profiling reveals activation of inflammation and apoptosis in the neonatal striatum after deep hypothermic circulatory arrest.

Tu LN, Timms AE, Kibiryeva N, Bittel D, Pastuszko A, Nigam V, Pastuszko P.

J Thorac Cardiovasc Surg. 2019 Sep;158(3):882-890.e4. doi: 10.1016/j.jtcvs.2019.02.091. Epub 2019 Mar 6.

PMID: 31005300

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Select item 30982585

 

  1. Postoperative cerebral oxygenation was not associated with new brain injury in infants with congenital heart disease.

Claessens NHP, Jansen NJG, Breur JMPJ, Algra SO, Stegeman R, Alderliesten T, van Loon K, de Vries LS, Haas F, Benders MJNL, Lemmers PMA.

J Thorac Cardiovasc Surg. 2019 Sep;158(3):867-877.e1. doi: 10.1016/j.jtcvs.2019.02.106. Epub 2019 Mar 14.

PMID: 30982585

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Select item 30801451

 

  1. Combined interventional procedure and cardiopulmonary bypass surgery in a dog with cor triatriatum dexter, patent foramen ovale, and pulmonary stenosis.

Marchesotti F, Rondelli V, Pesaresi M, Nicoli S, Vezzosi T, Auriemma E, Lanzillo G, Cuccio A, Khouri T, Dejong A, Domenech O.

J Vet Intern Med. 2019 Sep;33(5):2227-2234. doi: 10.1111/jvim.15580. Epub 2019 Aug 5.

PMID: 31380593 Free PMC Article

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Select item 31456377

 

  1. [Ventricular Septal Defect Patch Closure].

Nakano T.

Kyobu Geka. 2019 Sep;72(10):799-804. Japanese.

PMID: 31582699

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Select item 31582693

 

  1. [The Techniques of Atrial, Ventricular Incision and Closure].

Kin H.

Kyobu Geka. 2019 Sep;72(10):767-771. Japanese.

PMID: 31582693

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Select item 31506414

 

  1. [Emergency Patch Closure of Coronary Artery Fistula During the Neonatal Period;Report of a Case].

Kuwahara Y, Takahashi Y, Wada N.

Kyobu Geka. 2019 Sep;72(9):707-711. Japanese.

PMID: 31506414

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Select item 31283925

 

  1. Standard median sternotomy, right minithoracotomy, totally thoracoscopic surgery, percutaneous closure, and transthoracic closure for atrial septal defects in children: A protocol for a network meta-analysis.

Yi K, Guo X, You T, Wang Y, Ding F, Hou X, Zhou L.

Medicine (Baltimore). 2019 Sep;98(38):e17270. doi: 10.1097/MD.0000000000017270.

PMID: 31568005 Free Article

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Select item 31567953

 

  1. Comparison of inhospital outcomes of pediatric heart transplantation between single ventricle congenital heart disease and cardiomyopathy.

Bradford TT, Daily JA, Lang SM, Gossett JM, Tang X, Collins RT 2nd.

Pediatr Transplant. 2019 Sep;23(6):e13495. doi: 10.1111/petr.13495. Epub 2019 Jun 6.

PMID: 31169342

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Select item 31325555

 

  1. Inadequate oxygen delivery index dose is associated with cardiac arrest risk in neonates following cardiopulmonary bypass surgery.

Futterman C, Salvin JW, McManus M, Lowry AW, Baronov D, Almodovar MC, Pineda JA, Nadkarni VM, Laussen PC, Gazit AZ.

Resuscitation. 2019 Sep;142:74-80. doi: 10.1016/j.resuscitation.2019.07.013. Epub 2019 Jul 17.

PMID: 31325555

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Select item 31483301

 

  1. Pulmonary Embolism in a Neonate Following Modified Norwood Procedure With Sano Shunt.

Schlueter SM, Wilhelm M, Anagnostopoulos PV, Al-Subu AM.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):638-640. doi: 10.1177/2150135119853283.

PMID: 31496419

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Select item 31496416

 

  1. Norwood Procedure With Left Ventricle Exclusion in Complex Single Ventricle Patients: A Novel Technique.

Riggs KW, Kavoosi TA, Kroslowitz B, Zafar F, Heydarian HC, Morales DLS.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):552-557. doi: 10.1177/2150135119860465.

PMID: 31496416

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Select item 31496414

 

  1. Lecompte Procedure for Relief of Severe Airway Compression in Children With Congenital Heart Disease.

Greene CL, Mainwaring RD, Sidell D, Palmon M, Hanley FL.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):558-564. doi: 10.1177/2150135119860466.

PMID: 31496414

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Select item 31496410

 

  1. Prevalence of Culture-Negative Fever in Infants With Down Syndrome Undergoing Cardiac Surgery.

Vergales J, Seckeler MD, Chew J, Gangemi J.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):599-603. doi: 10.1177/2150135119864575.

PMID: 31496410

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Select item 31496407

 

  1. Smart Graft Monitoring After the Fontan Operation.

Rhodes JF Jr, Patel M, Burke RP.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):628-631. doi: 10.1177/2150135119852586.

PMID: 31496407

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Select item 31496405

 

  1. Pulmonary Allograft Versus Medtronic Freestyle Valve in Surgical Pulmonary Valve Replacement for Adults Following Correction of Tetralogy of Fallot or Its Variants.

Wijayarathne PM, Skillington P, Menahem S, Thuraisingam A, Larobina M, Grigg L.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):543-551. doi: 10.1177/2150135119859853.

PMID: 31496405

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Select item 31496400

 

  1. Impact of 3D Printouts in Optimizing Surgical Results for Complex Congenital Heart Disease.

Han F, Co-Vu J, Lopez-Colon D, Forder J, Bleiweis M, Reyes K, DeGroff C, Chandran A.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):533-538. doi: 10.1177/2150135119852316.

PMID: 31496399

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  1. Optimizing Postcardiac Transplantation Outcomes in Children with Ventricular Assist Devices: How Long Should the Bridge Be?

Riggs KW, Zafar F, Lorts A, Villa CR, Bryant R 3rd, Morales DLS.

ASAIO J. 2019 Sep 30. doi: 10.1097/MAT.0000000000001075. [Epub ahead of print]

PMID: 31577626

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Select item 31567418

 

  1. Bivalirudin Experience in a Heterogeneous Ventricular Assist Device Population.

Bates A, Buchholz H, Freed D, MacArthur R, Pibdorochynski T, Conway J.

ASAIO J. 2019 Sep 30. doi: 10.1097/MAT.0000000000001062. [Epub ahead of print]

PMID: 31567418

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Select item 31566150

 

  1. Outcomes of Infants Supported With Extracorporeal Membrane Oxygenation Using Centrifugal Versus Roller Pumps: An Analysis From the Extracorporeal Life Support Organization Registry.

O’Halloran CP, Thiagarajan RR, Yarlagadda VV, Barbaro RP, Nasr VG, Rycus P, Anders M, Alexander PMA.

Pediatr Crit Care Med. 2019 Sep 27. doi: 10.1097/PCC.0000000000002103. [Epub ahead of print]

PMID: 31567621

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Select item 31562687

 

  1. Patients and their family members prioritize post-transplant survival over waitlist survival when considering donor hearts for transplantation.

Godown J, Schumacher KR, Butler A, Chapman G, Dipchand AI, Kaslow WW, Bearl DW, Kirk R.

Pediatr Transplant. 2019 Sep 27:e13589. doi: 10.1111/petr.13589. [Epub ahead of print]

PMID: 31562687

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Select item 31554525

 

  1. End-Stage Liver Disease Models and Outcomes in Pediatric Patients Supported With Short-Term Continuous-Flow Ventricular Assist Devices.

Malik G, Pidborochynski T, Buchholz H, Freed DH, Al-Aklabi M, Bozso SJ, Choudhry S, Anand V, Holinski P, Conway J.

ASAIO J. 2019 Sep 25. doi: 10.1097/MAT.0000000000001078. [Epub ahead of print]

PMID: 31567409

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Select item 31567407

 

  1. 2-Year Outcomes After Complete or Staged Procedure for Tetralogy of Fallot in Neonates.

Savla JJ, Faerber JA, Huang YV, Zaoutis T, Goldmuntz E, Kawut SM, Mercer-Rosa L.

J Am Coll Cardiol. 2019 Sep 24;74(12):1570-1579. doi: 10.1016/j.jacc.2019.05.057.

PMID: 31537267

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Select item 31561960

 

  1. Association of Clinical Rejection vs. Rejection on Protocol Biopsy with Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients.

Asimacopoulos EP, Garbern JC, Gauvreau K, Blume ED, Daly KP, Singh TP.

Transplantation. 2019 Sep 24. doi: 10.1097/TP.0000000000002983. [Epub ahead of print]

PMID: 31568274

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Select item 31547669

 

  1. Risk stratification models for congenital heart surgery in children: Comparative single-center study.

Bobillo-Perez S, Sanchez-de-Toledo J, Segura S, Girona-Alarcon M, Mele M, Sole-Ribalta A, Cañizo Vazquez D, Jordan I, Cambra FJ.

Congenit Heart Dis. 2019 Sep 23. doi: 10.1111/chd.12846. [Epub ahead of print]

PMID: 31545015

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Select item 31544560

 

  1. Prolonged cardiopulmonary resuscitation and low flow state are not contraindications for extracorporeal support.

Deshpande SR, Vaiyani D, Cuadrado AR, McKenzie ED, Maher KO.

Int J Artif Organs. 2019 Sep 23:391398819876940. doi: 10.1177/0391398819876940. [Epub ahead of print]

PMID: 31544560

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Select item 31510826

 

  1. Early assessment of cardiac troponin I predicts the postoperative cardiac status and clinical course after congenital heart disease surgery.

Kojima T, Toda K, Oyanagi T, Yoshiba S, Kobayashi T, Sumitomo N.

Heart Vessels. 2019 Sep 14. doi: 10.1007/s00380-019-01497-9. [Epub ahead of print]

PMID: 31522246

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  1. Bleeding and Thrombosis With Pediatric Extracorporeal Life Support: A Roadmap for Management, Research, and the Future From the Pediatric Cardiac Intensive Care Society (Part Two).

Penk JS, Reddy S, Polito A, Cisco MJ, Allan CK, Bembea M, Giglia TM, Cheng HH, Thiagarajan RR, Dalton HJ.

Pediatr Crit Care Med. 2019 Sep 12. doi: 10.1097/PCC.0000000000002104. [Epub ahead of print]

PMID: 31517728

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  1. Valve-sparing repair with skeletonization of the pulmonary annulus for tetralogy of Fallot.

Türköz R, Doğan A, Oktay A, Saygılı A.

J Card Surg. 2019 Sep 11. doi: 10.1111/jocs.14252. [Epub ahead of print]

PMID: 31508849

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Select item 31507010

 

  1. Regionalization of Congenital Heart Surgery in the United States.

Welke KF, Pasquali SK, Lin P, Backer CL, Overman DM, Romano JC, Karamlou T.

Semin Thorac Cardiovasc Surg. 2019 Sep 10. pii: S1043-0679(19)30274-6. doi: 10.1053/j.semtcvs.2019.09.005. [Epub ahead of print]

PMID: 31518703

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Select item 31505063

 

  1. Incidence of ESKD and Mortality among Children with Congenital Heart Disease after Cardiac Surgery.

Parikh CR, Greenberg JH, McArthur E, Thiessen-Philbrook H, Everett AD, Wald R, Zappitelli M, Chanchlani R, Garg AX.

Clin J Am Soc Nephrol. 2019 Sep 9. pii: CJN.00690119. doi: 10.2215/CJN.00690119. [Epub ahead of print]

PMID: 31501090

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Select item 31501999

 

  1. A challenging case of severe pulmonary bleeding in a patient with congenital ventricular septal defect (VSD) and Eisenmenger syndrome: extracorporeal membrane oxygenation (ECMO) support and weaning strategies.

Udi J, Köhler TC, Grohmann J, Bäuml M, Grundmann S, Bode C, Biever P, Duerschmied D.

Clin Res Cardiol. 2019 Sep 9. doi: 10.1007/s00392-019-01544-5. [Epub ahead of print] No abstract available.

PMID: 31501999

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Select item 31516692

 

  1. Effect of Trisomy 21 on Postoperative Length of Stay and Non-cardiac Surgery After Complete Repair of Tetralogy of Fallot.

Purifoy ET, Spray BJ, Riley JS, Prodhan P, Bolin EH.

Pediatr Cardiol. 2019 Sep 7. doi: 10.1007/s00246-019-02196-y. [Epub ahead of print]

PMID: 31494702

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Select item 31489778

 

  1. Hospital readmission following pediatric heart transplantation.

Mahle WT, Mason KL, Dipchand AI, Richmond M, Feingold B, Canter CE, Hsu DT, Singh TP, Shaddy RE, Armstrong BD, Zeevi A, Iklé DN, Diop H, Odim J, Webber SA; CTOTC-04 Investigators.

Pediatr Transplant. 2019 Sep 4:e13561. doi: 10.1111/petr.13561. [Epub ahead of print]

PMID: 31483086

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Select item 31482597

 

  1. Acute Change in Ventricular Contractility-Load Coupling After Corrective Surgery for Congenital Heart Defect: A Retrospective Cohort Study.

Oh J, Song IK, Cho J, Yun TJ, Park CS, Choi JM, Gwak M, Shin WJ.

Pediatr Cardiol. 2019 Sep 3. doi: 10.1007/s00246-019-02195-z. [Epub ahead of print]

PMID: 31482237

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Select item 31482236

 

  1. Midline one-stage complete unifocalization early outcomes from a single center.

Korun O, Yurdakök O, Dedemoğlu M, Yücel İK, Çelebi A, Kudsioğlu ŞT, Sasmazel A, Aydemir NA.

Anatol J Cardiol. 2019 Sep;22(3):125-131. doi: 10.14744/AnatolJCardiol.2019.58235.

PMID: 31475955 Free PMC Article

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Select item 31475425

 

  1. Virtual three-dimensional model for preoperative planning in a complex case of a double outlet right ventricle.

Garekar S, Bharati A, Kothari F, Patil S, Dhake S, Mali S, Mhatre A, Bind D, Joshi A, Soni B, Malankar D.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):295-297. doi: 10.4103/apc.APC_141_18.

PMID: 31516286 Free PMC Article

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Select item 31516285

 

  1. Long-term follow-up and outcomes of discrete subaortic stenosis resection in children.

Abushaban L, Uthaman B, Selvan JP, Al Qbandi M, Sharma PN, Mariappa TV.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):212-219. doi: 10.4103/apc.APC_120_18.

PMID: 31516277 Free PMC Article

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Select item 31516276

 

  1. Improved 6 Minute Walk Distance and Brain-Type Natriuretic Peptide After Continuous-Flow Ventricular Assist Device Placement in Children.

Goldberg JF, Schlosser RS, Walrath JG, Morris SA, Elias BA, Price JF, Cabrera AG, Denfield SW, Dreyer WJ, Wang Y, Adachi I, Jeewa A.

ASAIO J. 2019 Sep/Oct;65(7):725-730. doi: 10.1097/MAT.0000000000000865.

PMID: 30161035

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Select item 30754985

 

  1. A complex case of aortic arch interruption and hypoplastic descending aorta.

Pérez-Andreu J, Fernández-Doblas J, Giralt García G, Roses F, Abella RF.

Asian Cardiovasc Thorac Ann. 2019 Sep;27(7):590-592. doi: 10.1177/0218492318804948. Epub 2019 Feb 12. No abstract available.

PMID: 30754985

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Select item 31400868

 

  1. Incidental finding of type A aortic dissection in a paediatric heart transplant recipient.

D’Addese L, Komarlu R, Zahka K.

Cardiol Young. 2019 Sep;29(9):1219-1221. doi: 10.1017/S1047951119001811.

PMID: 31451126

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Select item 31434603

 

  1. Neo-aortic insufficiency late after staged reconstruction for hypoplastic left heart syndrome: impact of differences in initial palliative procedures.

Umezu K, Harada Y, Sakamoto T, Okamura T, Shintomi S, Takigiku K, Yasukochi S.

Heart Vessels. 2019 Sep;34(9):1456-1463. doi: 10.1007/s00380-019-01376-3. Epub 2019 Mar 27.

PMID: 30915524

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  1. Early outcomes for low-risk pediatric heart transplant recipients and steroid avoidance: A multicenter cohort study (Clinical Trials in Organ Transplantation in Children – CTOTC-04).

Lamour JM, Mason KL, Hsu DT, Feingold B, Blume ED, Canter CE, Dipchand AI, Shaddy RE, Mahle WT, Zuckerman WA, Bentlejewski C, Armstrong BD, Morrison Y, Diop H, Iklé DN, Odim J, Zeevi A, Webber SA; CTOTC-04 investigators.

J Heart Lung Transplant. 2019 Sep;38(9):972-981. doi: 10.1016/j.healun.2019.06.006. Epub 2019 Jun 20.

PMID: 31324444

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  1. Experience of a single institution with femoral vein homograft as right ventricle to pulmonary artery conduit in stage 1 Norwood operation.

Kumar TKS, Zurakowski D, Briceno-Medina M, Shah A, Sathanandam S, Allen J, Sandhu H, Joshi VM, Boston U, Knott-Craig CJ.

J Thorac Cardiovasc Surg. 2019 Sep;158(3):853-862.e1. doi: 10.1016/j.jtcvs.2019.03.123. Epub 2019 May 11.

PMID: 31204139

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Select item 31126642

 

  1. Single-ventricle reconstruction 2.0: A closer look at our understanding of care for infants undergoing the Norwood procedure.

Karamlou T, Meza JM, Najm HK, Nigro JJ, Hill KD.

J Thorac Cardiovasc Surg. 2019 Sep;158(3):837-842.e5. doi: 10.1016/j.jtcvs.2018.12.121. Epub 2019 Apr 17. No abstract available.

PMID: 31101343

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  1. Extracorporeal Cardiopulmonary Resuscitation (ECPR) in Infants and Children: A Single-Center Retrospective Study.

Shakoor A, Pedroso FE, Jacobs SE, Okochi S, Zenilman A, Cheung EW, Middlesworth W.

World J Pediatr Congenit Heart Surg. 2019 Sep;10(5):582-589. doi: 10.1177/2150135119862598.

PMID: 31496406

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  1. Persistent femoral lymphatic leak following Fontan surgery: Role of fluorescein dye.

Gohain D, Menon S, Baruah SD, Ramanan SV, Dharan BS, Jayakumar K.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):350-351. doi: 10.4103/apc.APC_157_18. No abstract available.

PMID: 31516304 Free PMC Article

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  1. First report of successfully palliating a hypoplastic left heart syndrome patient with anomalous left coronary artery from the pulmonary artery beyond Fontan.

Riggs KW, Price NM, Szugye N, Goldstein BH, Morales DLS.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):318-320. doi: 10.4103/apc.APC_152_18.

PMID: 31516293 Free PMC Article

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  1. Severe thrombocytopenia in tetralogy of Fallot patients: A contraindication for corrective surgery?

Patil S, Relan J, Hote M, Kothari SS.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):305-307. doi: 10.4103/apc.APC_71_18.

PMID: 31516289 Free PMC Article

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  1. Surgical repair for common arterial trunk with pulmonary dominance, hypoplasia of ascending aorta, and interrupted aortic arch.

Talwar S, Siddharth B, Gupta SK, Bhoje A, Choudhary SK.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):287-291. doi: 10.4103/apc.APC_147_18.

PMID: 31516284 Free PMC Article

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97, Options for coronary translocation and other considerations in aortic root translocation (Bex-Nikaidoh procedure).

Vaidyanathan S, Supreet M, Shilpa M, Nelson A, Vijay A.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):228-232. doi: 10.4103/apc.APC_183_18.

PMID: 31516279 Free PMC Article

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Select item 3151627

Fetal Cardiology Featured Articles

Fetal Cardiology Reviews of September 2019 Manuscripts

 

Fetal Cardiology Reviews of September 2019 Manuscripts

Usefulness of Postnatal Echocardiography in Patients with Down Syndrome with Normal Fetal Echocardiograms.

Cooper A, Sisco K, Backes CH, Dutro M, Seabrook R, Santoro SL, Cua CL.

Pediatr Cardiol. 2019 Sep 20. doi: 10.1007/s00246-019-02209-w. [Epub ahead of print]

PMID: 31541264

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Take-Home Points: 

  • The incidence of significant congenital heart defects(CHD) on postnatal echocardiograms for patients with Down Syndrome (DS) who had a normal fetal echo is nearly zero.
  • Minor CHD, if present, will likely have an abnormal exam or EKG finding.
  • Delivery at a center without pediatric cardiology availability is likely reasonable.

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch:  A fetal echocardiogram is a class I recommendation if a chromosomal abnormality is present. The AHA currently recommends a postnatal echocardiogram in all patients with DS regardless of a normal fetal echocardiogram. With a new emphasis on appropriate use criteria in pediatric echocardiography, this may be a subgroup that could be further evaluated. The primary and secondary goals of this study was to determine if there was any missed complex CHD and any CHD postnatal echocardiograms after a normal fetal echo in DS patients. This was a retrospective evaluation of 120 total patients with suspected DS; 72 had complex CHD with the most common diagnoses AVSD and VSD. 45 patients had a normal fetal echo and also had a postnatal echo performed. Complex CHD was defined as a diagnosis with RACHS >/= 3.  PFO and PDA were not included as pathologic CHD diagnoses for the purpose of this study. The gestational age at the time of initial fetal echo was 25 +/- 3.5 weeks. The median age at postnatal echo was 7 days, with 24 patients having an echo within the first week of life. No patients had complex CHD; negative predictive value was 100%. 13 patients had minor CHD consisting mostly of ASDs or VSDs; negative predictive value 71.1%.  All of them had a heart murmur or EKG abnormality on evaluation. 1/13 patients died from severe PPHN. 3/13 required intervention (2 caths for PDA closure, 1 primum ASD repair). One other patient has a primum ASD that was still being followed (see table 1).

While fetal echocardiography does not have 100% sensitivity for ruling out CHD, this study adds weight to previous studies that missed complex CHD is very unlikely. At a minimum, in an otherwise uncomplicated pregnancy or in a region with many hospitals that do not have direct access to pediatric cardiology, it would seem quite reasonable to deliver patients with a negative fetal echo and refer them to pediatric cardiology within the first few weeks of life. There is unlikely enough evidence to change the postnatal echo recommendations given that there are many minor CHD diagnoses that need to be followed over time; however, the authors do speculate how AUC may be used in this population when adding other historical and clinical factors and an EKG. Limitations of this study include its small sample size and retrospective design, but this study could easily be replicated with a larger cohort.

 

 

Fetal Cardiology Sept 2019

  1. Usefulness of Postnatal Echocardiography in Patients with Down Syndrome with Normal Fetal Echocardiograms.

Cooper A, Sisco K, Backes CH, Dutro M, Seabrook R, Santoro SL, Cua CL.

Pediatr Cardiol. 2019 Sep 20. doi: 10.1007/s00246-019-02209-w. [Epub ahead of print]

PMID: 31541264

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  1. EX-UTERO EXTRACORPOREAL SUPPORT AS A MODEL FOR FETAL HYPOXIA AND BRAIN DYSMATURITY.

McGovern PE, Lawrence K, Baumgarten H, Rossidis A, Mejaddam A, Licht DJ, Grinspan J, Schupper A, Rychik J, Didier RA, Vossough A, Spray TL, Peranteau WH, Davey MG, Flake AW, Gaynor JW.

Ann Thorac Surg. 2019 Sep 18. pii: S0003-4975(19)31405-5. doi: 10.1016/j.athoracsur.2019.08.021. [Epub ahead of print]

PMID: 31541634

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  1. Parental reactions, distress, and sense of coherence after prenatal versus postnatal diagnosis of complex congenital heart disease.

Bratt EL, Järvholm S, Ekman-Joelsson BM, Johannsmeyer A, Carlsson SÅ, Mattsson LÅ, Mellander M.

Cardiol Young. 2019 Sep 16:1-7. doi: 10.1017/S1047951119001781. [Epub ahead of print]

PMID: 31522698

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Select item 31529177

 

  1. From embryogenesis to adulthood: Critical role for GATA factors in heart development and function.

Whitcomb J, Gharibeh L, Nemer M.

IUBMB Life. 2019 Sep 13. doi: 10.1002/iub.2163. [Epub ahead of print] Review.

PMID: 31520462

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Select item 31526640

 

  1. miR-486 is modulated by stretch and increases ventricular growth.

Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Börgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman J, Del Álamo JC, Nigam V.

JCI Insight. 2019 Sep 12;4(19). pii: 125507. doi: 10.1172/jci.insight.125507.

PMID: 31513548 Free Article

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Select item 28613785

 

  1. The added value of screening fetal echocardiography after normal cardiac views on a detailed ultrasound.

Cawyer CR, Kuper SG, Ausbeck E, Sinkey RG, Owen J.

Prenat Diagn. 2019 Sep 9. doi: 10.1002/pd.5557. [Epub ahead of print]

PMID: 31499581

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  1. Absence of the fetal right pulmonary artery complicated with coarctation of the aorta: Prenatal and postnatal diagnosis.

Wang Y, Zhang J, Feng W, Wu Y, Yang L, Yin J.

Echocardiography. 2019 Sep 5. doi: 10.1111/echo.14470. [Epub ahead of print]

PMID: 31487058

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Select item 31488903

 

  1. Application of the INTERGROWTH-21st chart compared to customized growth charts in fetuses with left heart obstruction: late trimester biometry, cerebroplacental hemodynamics and perinatal outcome.

Graupner O, Helfrich F, Ostermayer E, Lobmaier SM, Ortiz JU, Ewert P, Wacker-Gussmann A, Haller B, Axt-Fliedner R, Enzensberger C, Abel K, Karge A, Oberhoffer R, Kuschel B.

Arch Gynecol Obstet. 2019 Sep;300(3):601-613. doi: 10.1007/s00404-019-05198-6. Epub 2019 May 28.

PMID: 31139902

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  1. Epigenetics and Mechanobiology in Heart Development and Congenital Heart Disease.

Jarrell DK, Lennon ML, Jacot JG.

Diseases. 2019 Sep 1;7(3). pii: E52. doi: 10.3390/diseases7030052. Review.

PMID: 31480510 Free Article

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  1. Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations.

Lytzen R, Vejlstrup N, Bjerre J, Petersen OB, Leenskjold S, Dodd JK, Jørgensen FS, Søndergaard L.

Int J Cardiol. 2019 Sep 1;290:93-99. doi: 10.1016/j.ijcard.2019.05.017. Epub 2019 May 7.

PMID: 31130278

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Select item 31085083

 

  1. Obstetric and perinatal outcomes in pregnancies with isolated foetal congenital heart abnormalities.

Liu C, Lodge J, Flatley C, Gooi A, Ward C, Eagleson K, Kumar S.

J Matern Fetal Neonatal Med. 2019 Sep;32(18):2985-2992. doi: 10.1080/14767058.2018.1453799. Epub 2018 Apr 3.

PMID: 29544375

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Select item 31074499

 

  1. Fetal whole-heart 4D imaging using motion-corrected multi-planar real-time MRI.

van Amerom JFP, Lloyd DFA, Deprez M, Price AN, Malik SJ, Pushparajah K, van Poppel MPM, Rutherford MA, Razavi R, Hajnal JV.

Magn Reson Med. 2019 Sep;82(3):1055-1072. doi: 10.1002/mrm.27798. Epub 2019 May 12.

PMID: 31081250 Free PMC Article

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Select item 31378336

 

  1. Isolated abdominal aortic tortuosity diagnosed by fetal echocardiography.

Ishido H, Baba K, Maeda S, Doi H, Iwamoto Y, Senzaki H, Masutani S.

J Echocardiogr. 2019 Sep 7. doi: 10.1007/s12574-019-00441-0. [Epub ahead of print] No abstract available.

PMID: 31494840

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Select item 31494702

 

  1. Atrial and ventricular ejection force of the fetal heart: Which of the four chambers is the dominant?

Malakan Rad E, Sheykhian T, Zeinaloo AA.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):220-227. doi: 10.4103/apc.APC_146_18.

PMID: 31516278 Free PMC Article

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Select item 31516277

 

  1. Application of the INTERGROWTH-21st chart compared to customized growth charts in fetuses with left heart obstruction: late trimester biometry, cerebroplacental hemodynamics and perinatal outcome.

Graupner O, Helfrich F, Ostermayer E, Lobmaier SM, Ortiz JU, Ewert P, Wacker-Gussmann A, Haller B, Axt-Fliedner R, Enzensberger C, Abel K, Karge A, Oberhoffer R, Kuschel B.

Arch Gynecol Obstet. 2019 Sep;300(3):601-613. doi: 10.1007/s00404-019-05198-6. Epub 2019 May 28.

PMID: 31139902

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Select item 31519455

 

  1. Sensitivity, specificity, and accuracy of fetal echocardiography for high-risk pregnancies in a tertiary center in Egypt.

Rakha S, El Marsafawy H.

Arch Pediatr. 2019 Sep;26(6):337-341. doi: 10.1016/j.arcped.2019.08.001. Epub 2019 Sep 10.

PMID: 31519455

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Select item 30234505

 

  1. Marked Practice Variation in Antithrombotic Care with the Berlin Heart EXCOR Pediatric Ventricular Assist Device.

May LJ, Lorts A, VanderPluym C, Conway J, Massicotte MP, Millar MM, Steiner ME, Rosenthal DN.

ASAIO J. 2019 Sep/Oct;65(7):731-737. doi: 10.1097/MAT.0000000000000878.

PMID: 30234505

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Select item 30161035

 

  1. The genetic and clinical outcome of isolated fetal muscular ventricular septal defect (VSD).

Svirsky R, Brabbing-Goldstein D, Rozovski U, Kapusta L, Reches A, Yaron Y.

J Matern Fetal Neonatal Med. 2019 Sep;32(17):2837-2841. doi: 10.1080/14767058.2018.1449829. Epub 2018 Mar 20.

PMID: 29510647

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Select item 31169657

 

  1. Modified underlying cardiac disease severity in twin-twin transfusion syndrome.

Ishido H, Masutani S, Mikami Y, Baba K, Fuse M, Mizuta K, Tanaka R, Sugamoto K, Iwamoto Y, Senzaki H.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):336-338. doi: 10.4103/apc.APC_112_18.

PMID: 31516298 Free PMC Article

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Select item 31516297

 

  1. Functional cardiac measurements performed by two-dimensional Doppler echocardiography in normal fetuses: Determination of Z-scores and future prospects.

Rocha LA, Bravo-Valenzuela NJ, Rolo LC, Araujo Júnior E.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):233-239. doi: 10.4103/apc.APC_173_18. Review.

PMID: 31516280 Free PMC Article

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Select item 31516279

 

  1. Atrial and ventricular ejection force of the fetal heart: Which of the four chambers is the dominant?

Malakan Rad E, Sheykhian T, Zeinaloo AA.

Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):220-227. doi: 10.4103/apc.APC_146_18.

PMID: 31516278 Free PMC Article

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Congenital Cardiovascular Anesthesia and Critical Care Featured Articles

CHD anesthesia and intensive care August 2019

 

CHD Anesthesia Sept 2019

  1. Central Venous Catheter-Related Deep Vein Thrombosis in the Pediatric Cardiac Intensive Care Unit.

Steen EH, Lasa JJ, Nguyen TC, Keswani SG, Checchia PA, Anders MM.

J Surg Res. 2019 Sep;241:149-159. doi: 10.1016/j.jss.2019.03.052. Epub 2019 Apr 23.

PMID: 31026793

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Select item 31277816

 

  1. Evaluation of an updated sedation protocol to reduce benzodiazepines in a pediatric intensive care unit.

Michel J, Hofbeck M, Peper AK, Kumpf M, Neunhoeffer F.

Curr Med Res Opin. 2019 Sep 17:1-6. doi: 10.1080/03007995.2019.1663689. [Epub ahead of print]

PMID: 31526142

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Select item 31529991

 

  1. Preoperative Physiology, Imaging, and Management of Coarctation of Aorta in Children.

Ganigara M, Doshi A, Naimi I, Mahadevaiah GP, Buddhe S, Chikkabyrappa SM.

Semin Cardiothorac Vasc Anesth. 2019 Sep 19:1089253219873004. doi: 10.1177/1089253219873004. [Epub ahead of print]

PMID: 31535945

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Select item 31541634

 

  1. Near-Infrared Spectroscopy in Pediatric Congenital Heart Disease.

Zaleski KL, Kussman BD.

J Cardiothorac Vasc Anesth. 2019 Sep 3. pii: S1053-0770(19)30915-2. doi: 10.1053/j.jvca.2019.08.048. [Epub ahead of print] Review.

PMID: 31582201

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Select item 31446821

 

  1. Novel Strategy of Subcutaneous Implantable Cardioverter Defibrillator Implantation Under Regional Anesthesia.

Braver O, Semyonov M, Reina Y, Konstantino Y, Haim M, Winter J.

J Cardiothorac Vasc Anesth. 2019 Sep;33(9):2513-2516. doi: 10.1053/j.jvca.2019.04.024. Epub 2019 Apr 26. No abstract available.

PMID: 31130315

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Select item 31072707

 

 

The CHIP Network Journal Watch Team

Konstantin Averin, MD, MS is an Associate Professor of Pediatrics at the University of Alberta and an Interventional Pediatric Cardiologist at the Stollery Children’s Hospital in Edmonton, Alberta. He received his medical degree from the Feinberg School of Medicine at Northwestern University in Chicago, IL. After medical school, he completed pediatrics residency, pediatric cardiology fellowship and sub-specialty training in pediatric and adult interventional cardiology at the Cincinnati Children’s Hospital in Cincinnati, OH. His clinical and research interests are focused on the percutaneous treatment of pediatric patients with congenital and acquired heart disease with a focus on patients with single ventricle physiology, transcatheter pulmonary valves, and pulmonary hypertension.

Dr. Leong Ming Chern “MC” is an adult congenital heart disease specialist at the National Heart Institute, Kuala Lumpur, Malaysia. He received his medical training at the University of Malaya and pediatric cardiology training at the National Heart Institute. His area of interest includes treatment of adult patients with congenital heart disease and pulmonary hypertension in congenital heart disease.

Dr. Damien Cullington, MBChB MRCP MD FESC is a consultant adult congenital cardiologist who works at Leeds General Infirmary, UK. In summer 2019, he will move over to the newly commissioned North West ACHD Service based in Liverpool, UK. Damien qualified in 2002 from the University of Liverpool and became a substantive consultant in 2016. Prior to this, he worked throughout the North of England and Yorkshire as a cardiology trainee. Damien was awarded a doctorate in medicine (MD) from the University of Hull in 2013 for his work in heart rate in patients with heart failure. He is a member of the Royal College of Physicians (London), Fellow of the European Society of Cardiology and honorary senior lecturer for the University of Leeds. His ACHD subspecialty clinical interests are heart failure, imaging and palliative care. He is regional organiser for ACHD training at Leeds and clinical governance lead for the Leeds congenital cardiac unit. His research interests and wide and far but particularly epidemiology, chronic heart failure in ACHD patients in all its guises, the systemic RV and the univentricle

Dr. Blanche Cupido is a consultant adult cardiologist working at Groote Schuur Hospital, UCT Private Academic Hospital and the University of Cape Town(UCT), South Africa. She completed her physician training in 2009 and her cardiology subspecialist training in 2013. She recently returned to SA after doing a Fellowship in Adult Congenital Heart Disease in Leeds, United Kingdom under the guidance of Dr Kate English. She has established a dedicated unit for Grown Up Congenital Heart Disease in Cape Town, South Africa. Her aim is to grow ACHD services in Sub-Saharan Africa and embark on GUCH research on the African continent.

Dr. Jeremy L. Herrmann is an Assistant Professor of Surgery in the Division of Thoracic and Cardiovascular Surgery at Indiana University. He specializes in pediatric and adult congenital cardiac surgery, and his clinical interests also include heart transplantation and mechanical circulatory support. His hospital affiliations include Indiana University Health Riley Hospital for Children and Methodist Hospital as well as Peyton Manning Children’s Hospital at St. Vincent Hospital in Indianapolis

Maan Jokhadar is a cardiologist and associate professor of medicine at Emory University in Atlanta, Georgia. He is board certified in internal medicine, cardiovascular disease, advanced heart failure/transplantation, adult congenital heart disease, and echocardiography. He is fellowship director for the Emory Adult Congenital Heart Disease training program and Core Curriculum Director for the Emory general cardiology fellowship program. Dr Jokhadar graduated from the University Damascus School of Medicine in Syria and then went to Mayo Clinic in Rochester, Minnesota for internal medicine residency. He then completed cardiology and subspecialty training at Emory University, where he currently on faculty. Dr. Jokhadar has been the recipient of numerous teaching awards. He is married with 3 children.

Michael Ma, MD is an Assistant Professor in Cardiothoracic Surgery in the Division of Pediatric Cardiac Surgery at Stanford University. He specializes in pediatric and adult congenital cardiac surgery, with an emphasis on neonates, complex biventricular repair, and pulmonary artery reconstruction. His research lab investigates ex and in vivo translational models for complex congenital heart disease, to optimize future surgical and endovascular repair strategies.

Jeremy P. Moore MD MS FHRS is the Director of Clinical Research and faculty in Pediatric Cardiology and Adult Congenital Heart Disease at the University of California, Los Angeles. Dr. Moore received his medical degree from the Medical College of Virginia in 2003. He completed residency and fellowship at UCLA before pursuing his subspecialty training in Pediatric Electrophysiology at Vanderbilt University in 2009. Dr. Moore has been faculty at UCLA since 2010 and has since published numerous research manuscripts dealing with electrophysiologic aspects pertinent to congenital heart disease. Dr. Moore’s primary interest is the study of mechanisms of arrhythmia, and the development of novel electrophysiologic techniques for management of the adult patient with congenital heart disease

Dr. Mehul Patel MD, is a structural and adult congenital heart disease specialist and an interventional cardiologist. Dr. Patel earned his undergraduate and medical education from the Mumbai University, India. After completing his post-graduate training in Internal Medicine and Cardiology, he further trained in interventional cardiology at the Mount Sinai Medical Center, NYC, NY and Adult Congenital Heart Disease at the Texas Children’s Hospital, Texas Heart Institute, Baylor College of Medicine, Houston, TX. Dr. Patel worked as Chief of adult congenital heart disease, Assistant Professor at the Michigan State University, Grand Rapids, MI where he not only expanded the program, performing complex interventions and device implantations but also established the percutaneous pulmonary valve implantation (Melody Valve) Program. Due to his passion for treating structurally abnormal hearts, he did a dedicated year of Structural Heart Disease fellowship at Henry Ford Hospital, Detroit, MI where he worked with pioneers in this field before moving to North Carolina. He is proficient in performing transcatheter aortic valve replacement (TAVR), MitraClip, Watchman device implantation, percutaneous Mitral, Tricuspid and Pulmonary valve replacements along with a variety of interventions on congenital heart disease and pulmonary hypertension. Dr. Patel is ABIM board certified in Internal Medicine, Cardiology, Interventional cardiology and Adult Congenital Heart Disease. Dr. Patel has more than 50 peer reviewed publications and numerous abstracts to his credit. He serves as a Co-Editor-in-Chief for the CHiP Network journal watch. His wife, Khyati is a pediatric cardiac Electrophysiologist and they have a 9-year-old daughter. Dr. Patel is also an artist, likes music, yoga and plays badminton. His clinical areas of expertise and interests are: 1) Transcatheter therapies for Structural and Adult Congenital heart disease. 2) Complex device implantations.

Dr. Timothy Pirolli is an Assistant Professor of Surgery in the Division of Pediatric Cardiothoracic Surgery at University of Texas Southwestern Medical Center. He specializes in pediatric and adult congenital cardiac surgery. His hospital affiliations include Children’s Medical Center in Dallas, Parkland Memorial Hospital, and Clements University Hospital (UTSW).

Dr. Inga Voges, M.D. Consultant in Pediatric Cardiology, Lead Consultant Cardiovascular MRI. I trained in General Pediatrics and Pediatric Cardiology in Rostock (Germany) and Kiel (Germany) from 2002-2010 and did additional training in Adult Congenital Heart Disease (ACHD) in Kiel (Germany) which I finished in 2014. I specialized in Cardiovascular Magnetic Resonance Imaging (CMR) and have a further special interest in cardiomyopathies. Currently, I am working as a consultant pediatric and ACHD cardiologist at the University Hospital Schleswig-Holstein (Kiel, Germany) where I am responsible for the CMR imaging program in pediatric and ACHD patients and contribute to the care of patients with acquired and congenital heart disease. I received my MD from the Medical University Luebeck in 2006 (Germany) and finished my “Habilitation” (PhD equivalent; University Hospital Kiel, Germany) in 2014. Since 2016, I am the secretary of the Association for European Paediatric and Congenital Cardiology Imaging Working Group.

Dr. Gary Webb, M.D. is an Emeritus Professor of Pediatrics and Internal Medicine at the University of Cincinnati College of Medicine and,
from 2009-2016, the Director of the Adult Congenital Heart Program at Cincinnati Children’s Hospital Heart Institute. A graduate of McGill
University in Montréal, he interned at the Royal Victoria Hospital, and then trained in internal medicine and cardiology at the University of Toronto. From 1980-2004, he was co-director and then director of the Toronto Congenital Cardiac Center for Adults at Toronto General Hospital. He is a Fellow of the Royal College of Physicians and Surgeons of Canada in both internal medicine and cardiology. From 2004-2009, he was director of the Philadelphia Adult Congenital Heart Center at the University of Pennsylvania. Since 2016, he has been a consultant to Cincinnati Children’s Hospital, and has been responsible for the ACHD Learning Center, the Cardiology Fellow Testing Center, and the Congenital Heart Professionals International (CHIP) Network. Since 2017, he has resumed seeing patients on a part-time basis at the Toronto Congenital Cardiac Centre for Adults.

Wendy Whiteside, MD Wendy is Assistant Professor of Pediatrics and Associate Director of Interventional Pediatric Cardiology at the University of Michigan Congenital Heart Center, C.S. Mott Children’s Hospital. She obtained her medical degree from Albert Einstein College of Medicine in 2006 then completed pediatric residency at Children’s Hospital Oakland in Oakland, CA in 2009. She received
both her categorical and interventional pediatric cardiology training at the University of Michigan in Ann Arbor, MI. Her clinical and research interests include single ventricle physiology, transcatheter
pulmonary valves, and quality improvement within the cardiac catheterization laboratory.

About the Congenital Heart and Pediatric Cardiac Journal Watch

Congenital heart and pediatric cardiac Journal Watch was designed to make it easier for congenital heart and pediatric cardiac professionals to keep up with the literature in 6 subsections of congenital heart disease abstracts on a monthly basis: pediatric cardiology; congenital heart surgery; congenital  heart interventions; congenital/pediatric electrophysiology; fetal cardiology; and adult congenital heart disease.

We encourage your continued support as well as your valuable comments and feedback.

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Sincerely,

Dr. Gary Webb, MD and Dr. Mehul Patel
CHiP Network
Congenital Heart and Pediatic Cardiac Journal Watch Editorial Board

The Chip Network, the Congenital Heart International Professionals Network, aims to develop a single global list of all congenital and pediatric cardiac professionals.

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