CHiP Network Congenital Heart Journal Watch – September 2019

Pediatric Cardiology Featured Articles

Pediatric Cardiology Reviews of July 2019 Manuscripts

 

Increased extracellular volume in the liver of pediatric Fontan patients.
de Lange C, Reichert MJE, Pagano JJ, Seed M, Yoo SJ, Broberg CS, Lam CZ, Grosse-Wortmann L.
J Cardiovasc Magn Reson. 2019 Jul 15;21(1):39. doi: 10.1186/s12968-019-0545-4.
PMID: 31303178 Free PMC Article
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Take Home Points:

• In Fontan survivors, elevated systemic venous congestion, reduced cardiac output and a multitude of other hepatic insults including often multiple prior cardiac surgeries results in Fontan associated liver disease (FALD) characterized by hepatic congestion, and fibrosis.
• In Fontan patients, varying degrees of FALD is universal and progressive. Cirrhosis and hepatocellular carcinoma are known morbidities of advanced FALD.
• The natural history of FALD and factors influencing its progress are unclear. Traditional serological markers of hepatic function fail to provide adequate insight into severity and progression of FALD until late in the disease process.
• Cardiac magnetic resonance imaging T1 mapping of liver and young Fontan patient is feasible.
• Fontan survivors showed elevated native T1 and ECV values compared to both bidirectional cavopulmonary anastomosis subjects and controls suggesting diffuse hepatic congestion and/or fibrosis.
• Subjects with Fontan as well as bidirectional cavopulmonary anastomosis showed elevated native T1 compared to control indicating hepatic congestion even in subjects with bidirectional cavopulmonary anastomosis.
• In Fontan subjects, T1 values correlated with exposure to cardiopulmonary bypass time but not to central venous pressure or age.
• Native T1 and ECV values may be useful imaging biomarkers to evaluate hepatic congestion and fibrosis in FALD.
• ECV does not provide clinically significant additional information compared to native T1 analysis. Relying on native T1 analysis obviates the need for gadolinium and reduces the postprocessing and scan time.

Commentary from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch: This is a retrospective cross-sectional cohort study of pediatric patients with bidirectional cavopulmonary anastomosis and Fontan procedures. Hepatic native T1 times and ECV was measured using cardiac short axis modified Look-Locker inversion recovery sequence retrospectively from images displaying the liver. A multivariate regression model was performed for evaluating factors associated with native T1 times and ECV. Hepatic native T1 time were increased in Fontan patients (n = 62, 11.4 ± 4.4 years, T1 762 ± 64ms) versus BCPC patients (n = 20, 2.8 ± 0.9 years, T1 645 ± 43ms, p = 0.04). Both cohorts had higher T1 than controls (n = 44, 13.7 ± 2.9 years, T1 604 ± 54ms, p < 0.001 for both). ECV was 41.4 ± 4.8% in Fontan and 36.4 ± 4.8% in BCPC patients, respectively (p = 0.02). In Fontan patients, T1 values correlated with exposure to cardiopulmonary bypass time (R = 0.3, p = 0.02), systolic and end diastolic volumes (R = 0.3, p = 0.04 for both) and inversely with oxygen saturations and body surface area (R = -0.3, p = 0.04 for both). There were no demonstrable associations of T1 or ECV with central venous pressure or age after Fontan.

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Figure 2

Multicentre reference values for cardiac magnetic resonance imaging derived ventricular size and function for children aged 0-18 years.
van der Ven JPG, Sadighy Z, Valsangiacomo Buechel ER, Sarikouch S, Robbers-Visser D, Kellenberger CJ, Kaiser T, Beerbaum P, Boersma E, Helbing WA.
Eur Heart J Cardiovasc Imaging. 2019 Jul 5. pii: jez164. doi: 10.1093/ehjci/jez164. [Epub ahead of print]
PMID: 31280290
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Take Home Points:

• Cardiovascular magnetic resonance (CMR) imaging is now considered the “gold standard” imaging tool for assessment of cardiac volume and function in pediatric cardiac disease.
• This relatively large multicenter study provides reference values from steady-state free precession (SSFP) CMR for biventricular volumes and mass.

Commentary from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch: A total of 141 healthy children (68 boys) from three European centres underwent cine-SSFP CMR imaging. Cardiac structures were manually contoured for end-diastolic and end-systolic phases in the short-axis orientation according to current standardized CMR post-processing guidelines. Volumes and masses were derived from these contours. Age-related reference curves were constructed using the lambda mu sigma method. Median age was 12.7 years (range 0.6–18.5).

Impact of Right Ventricular Geometry and Left Ventricular Hypertrophy on Right Ventricular Mechanics and Clinical Outcomes in Hypoplastic Left Heart Syndrome.
Rösner A, Bharucha T, James A, Mertens L, Friedberg MK.
J Am Soc Echocardiogr. 2019 Jul 24. pii: S0894-7317(19)30767-9. doi: 10.1016/j.echo.2019.06.003. [Epub ahead of print]
PMID: 31351794
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Take Home Points:

• In patients with hypoplastic left heart syndrome, right ventricular function is a key determinant of long-term transplant free survival.
• The impact of geometry of the systemic right ventricle and hypoplastic left ventricle on right ventricular mechanics is poorly understood.
• Right ventricular apical bulging resulting from the hypertrophied and hypoplastic left ventricle negatively impact both regional and global right ventricular systolic function (figure 2 and 3).
• Although left ventricular hypertrophy is often seen in the setting of mitral stenosis and aortic atresia, apical bulging was present in all anatomic subtypes.
• There was suggestion of association between reduced right ventricular strain and death or transplant specifically in the subset with apical bulging (figure 6).

Commentary from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch: This is a retrospective cohort study of 48 hypoplastic left heart syndrome patient from the Hospital for Sick Children, Toronto with the median age of 2.2 years. Right ventricle apical bulging defined as a sigmoid shaped septum with the right ventricle leftward apical segment contiguous with the left ventricle lateral wall. Regional and global right ventricular strain were measured using speckle tracking echocardiography and comparisons were made between those with apical bulging and dose without apical bulging. RV global (–7.3% 6 2.8% vs –11.2% 6 4.4%; P = .001), basal septal (–3.8% 6 3.2% vs –11.4% 6 5.8%; P = .0001) and apicolateral (–5.1% 6 3.5% vs –8.0% 6 5.8%, P = .001) longitudinal strain were lower in patients with versus without apical bulging, respectively. Apical bulging was equally prevalent in all HLHS anatomical variants.

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Pediatric cardiology July 2019

 

  1. Postoperative brain volumes are associated with one-year neurodevelopmental outcome in children with severe congenital heart disease.

Meuwly E, Feldmann M, Knirsch W, von Rhein M, Payette K, Dave H, Tuura ROG, Kottke R, Hagmann C, Latal B, Jakab A; Research Group Heart and Brain*.

Sci Rep. 2019 Jul 26;9(1):10885. doi: 10.1038/s41598-019-47328-9.

PMID: 31350426 Free PMC Article

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  1. Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension.

Lambert M, Capuano V, Boet A, Tesson L, Bertero T, Nakhleh MK, Remy S, Anegon I, Péchoux C, Hautefort A, Rücker-Martin C, Manoury B, Domergue V, Mercier O, Girerd B, Montani D, Perros F, Humbert M, Antigny F.

Circ Res. 2019 Jul 26. doi: 10.1161/CIRCRESAHA.119.314793. [Epub ahead of print]

PMID: 31347976

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  1. [The left outflow tract: normal features].

Quarello E.

Gynecol Obstet Fertil Senol. 2019 Jul 25. pii: S2468-7189(19)30232-6. doi: 10.1016/j.gofs.2019.07.009. [Epub ahead of print] French.

PMID: 31352143

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  1. Border Medicine: The Pediatric Cardiology Perspective.

Agrawal A, Swaminathan S, Guvvala SL, Gorla SR.

Pediatr Cardiol. 2019 Jul 25. doi: 10.1007/s00246-019-02171-7. [Epub ahead of print]

PMID: 31342117

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  1. Prediction of biventricular repair by echocardiography in borderline ventricle.

Ma XJ, Huang GY.

Chin Med J (Engl). 2019 Jul 24. doi: 10.1097/CM9.0000000000000375. [Epub ahead of print]

PMID: 31348032

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  1. Impact of Right Ventricular Geometry and Left Ventricular Hypertrophy on Right Ventricular Mechanics and Clinical Outcomes in Hypoplastic Left Heart Syndrome.

Rösner A, Bharucha T, James A, Mertens L, Friedberg MK.

J Am Soc Echocardiogr. 2019 Jul 24. pii: S0894-7317(19)30767-9. doi: 10.1016/j.echo.2019.06.003. [Epub ahead of print]

PMID: 31351794

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  1. Newborn pulse oximetry screening in the context of a high antenatal detection rate for critical congenital heart disease.

Cloete E, Bloomfield FH, Cassells SA, de Laat MWM, Sadler L, Gentles TL.

Acta Paediatr. 2019 Jul 23. doi: 10.1111/apa.14946. [Epub ahead of print]

PMID: 31332832

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  1. Insights into Arch Vessel Development in the Bovine Aortic Arch.

Meyer AM, Turek JW, Froud J, Endelman LA, Cavanaugh NB, Torres JE, Ashwath R.

Pediatr Cardiol. 2019 Jul 22. doi: 10.1007/s00246-019-02156-6. [Epub ahead of print]

PMID: 31332468

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  1. The study of copy number variations in the regions of PRKAB2 and PPM1K among congenital heart defects patients.

Dong HQ, Du YX.

Rev Assoc Med Bras (1992). 2019 Jul 22;65(6):786-790. doi: 10.1590/1806-9282.65.6.786.

PMID: 31340305 Free Article

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  1. Association study of a functional variant of TNF-α gene and serum TNF-α level with the susceptibility of congenital heart disease in a Chinese population.

Pan J, Hu J, Qi X, Xu L.

Postgrad Med J. 2019 Jul 19. pii: postgradmedj-2019-136621. doi: 10.1136/postgradmedj-2019-136621. [Epub ahead of print]

PMID: 31324728

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  1. Novel mutation in OCRL leading to a severe form of Lowe syndrome.

Zhou FQ, Wang QW, Liu ZZ, Zhang XL, Wang DN, Dongye MM, Lin HT, Chen WR.

Int J Ophthalmol. 2019 Jul 18;12(7):1057-1060. doi: 10.18240/ijo.2019.07.01. eCollection 2019.

PMID: 31341792 Free PMC Article

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  1. Is Doppler echocardiography useful for estimating left ventricular filling pressures in pediatric heart transplant recipients?

Lunze FI, Narciso R, Gauvreau K, Blume ED, Colan SD, Singh TP.

Pediatr Transplant. 2019 Jul 16:e13543. doi: 10.1111/petr.13543. [Epub ahead of print]

PMID: 31313435

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  1. Arterial tissue transcriptional profiles associate with tissue remodeling and cardiovascular phenotype in children with end-stage kidney disease.

Freise C, Schaefer B, Bartosova M, Bayazit A, Bauer U, Pickardt T, Berger F, Rasmussen LM, Jensen PS, Laube G, Mencarelli F, Arbeiter K, Büscher R, Habbig S, Möller K, Kirchner M, Schaefer F, Schmitt CP, Querfeld U.

Sci Rep. 2019 Jul 16;9(1):10316. doi: 10.1038/s41598-019-46805-5.

PMID: 31311999 Free PMC Article

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  1. Accuracy of a portable pulse oximeter in monitoring hypoxemic infants with cyanotic heart disease.

Harris BU, Stewart S, Verma A, Hoen H, Stein ML, Wright G, Ramamoorthy C.

Cardiol Young. 2019 Jul 15:1-5. doi: 10.1017/S1047951119001355. [Epub ahead of print]

PMID: 31304897

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  1. Ductus Venosus Agenesis as a Marker of Pallister-Killian Syndrome.

Lapresa Alcalde MV, Cubo AM, Martín Seisdedos MC, Cortejoso Hernández J, Doyague Sanchez MJ, Sayagués JM.

Medicina (Kaunas). 2019 Jul 15;55(7). pii: E374. doi: 10.3390/medicina55070374.

PMID: 31311125 Free Article

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  1. Pulse oximetry screening in a midwifery-led maternity setting with high antenatal detection of congenital heart disease.

Cloete E, Gentles TL, Webster DR, Davidkova S, Dixon LA, Alsweiler JM, Bloomfield FH; Pulse Oximetry Screening Steering Committee.

Acta Paediatr. 2019 Jul 12. doi: 10.1111/apa.14934. [Epub ahead of print]

PMID: 31298757

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  1. Brain development of children with single ventricle physiology or transposition of the great arteries: A longitudinal observation study.

Hiraiwa A, Kawasaki Y, Ibuki K, Hirono K, Matsui M, Yoshimura N, Origasa H, Oishi K, Ichida F.

Semin Thorac Cardiovasc Surg. 2019 Jul 12. pii: S1043-0679(19)30188-1. doi: 10.1053/j.semtcvs.2019.06.013. [Epub ahead of print]

PMID: 31306764

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  1. Alternative approach to pediatric cardiac quality assessment for low-volume centers.

Delaney AE, Dadlez NM, Marshall AC.

Congenit Heart Dis. 2019 Jul 10. doi: 10.1111/chd.12821. [Epub ahead of print]

PMID: 31290585

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  1. From Diagnoses to Ongoing Journey: Parent Experiences Following Congenital Heart Disease Diagnoses.

Williams TS, McDonald KP, Roberts SD, Chau V, Seed M, Miller SP, Sananes R.

J Pediatr Psychol. 2019 Jul 10. pii: jsz055. doi: 10.1093/jpepsy/jsz055. [Epub ahead of print]

PMID: 31290975

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  1. Initial Experience of the Synchronized, Real-Time, Interactive, Remote Transthoracic Echocardiogram Consultation System in Rural China: Longitudinal Observational Study.

Liu L, Duan S, Zhang Y, Wu Y, Zhang L.

JMIR Med Inform. 2019 Jul 8;7(3):e14248. doi: 10.2196/14248.

PMID: 31287062 Free PMC Article

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  1. Fifteen-minute consultation: Assessing the child with a Blalock-Taussig shunt who is unwell in a district general hospital.

McVea S, McGettrick A.

Arch Dis Child Educ Pract Ed. 2019 Jul 5. pii: edpract-2018-315875. doi: 10.1136/archdischild-2018-315875. [Epub ahead of print]

PMID: 31278077

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  1. Multicentre reference values for cardiac magnetic resonance imaging derived ventricular size and function for children aged 0-18 years.

van der Ven JPG, Sadighy Z, Valsangiacomo Buechel ER, Sarikouch S, Robbers-Visser D, Kellenberger CJ, Kaiser T, Beerbaum P, Boersma E, Helbing WA.

Eur Heart J Cardiovasc Imaging. 2019 Jul 5. pii: jez164. doi: 10.1093/ehjci/jez164. [Epub ahead of print]

PMID: 31280290

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  1. Prevalence of Congenital Anomalies in the Japan Environment and Children’s Study.

Mezawa H, Tomotaki A, Yamamoto-Hanada K, Ishitsuka K, Ayabe T, Konishi M, Saito M, Yang L, Suganuma N, Hirahara F, Nakayama SF, Saito H, Ohya Y.

J Epidemiol. 2019 Jul 5;29(7):247-256. doi: 10.2188/jea.JE20180014. Epub 2018 Sep 22.

PMID: 30249945 Free PMC Article

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  1. Pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: the multifaceted consequences of PTPN11 mutations.

Calcagni G, Digilio MC, Marino B, Tartaglia M.

Orphanet J Rare Dis. 2019 Jul 5;14(1):163. doi: 10.1186/s13023-019-1151-0.

PMID: 31277675 Free PMC Article

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  1. ‘Big issues’ in neurodevelopment for children and adults with congenital heart disease.

Verrall CE, Blue GM, Loughran-Fowlds A, Kasparian N, Gecz J, Walker K, Dunwoodie SL, Cordina R, Sholler G, Badawi N, Winlaw D.

Open Heart. 2019 Jul 3;6(2):e000998. doi: 10.1136/openhrt-2018-000998. eCollection 2019. Review.

PMID: 31354955 Free PMC Article

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  1. T-Cell Receptor Excision Circles in Newborns with Congenital Heart Disease.

Davey BT, Elder RW, Cloutier MM, Bennett N, Lee JH, Wang Z, Manning A, Doan T, Griffiths M, Perez M, Ahluwalia N, Toro-Salazar OH.

J Pediatr. 2019 Jul 2. pii: S0022-3476(19)30678-X. doi: 10.1016/j.jpeds.2019.05.061. [Epub ahead of print]

PMID: 31277900

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  1. Prevalence and Types of Aortic Arch Variants and Anomalies in Congenital Heart Diseases.

Tawfik AM, Sobh DM, Ashamallah GA, Batouty NM.

Acad Radiol. 2019 Jul;26(7):930-936. doi: 10.1016/j.acra.2018.08.023. Epub 2018 Sep 25.

PMID: 30266547

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  1. Post-surgical chronic pain and quality of life in children operated for congenital heart disease.

Matsuda M, Takemura H, Yamashita A, Matsuoka Y, Sawa T, Amaya F.

Acta Anaesthesiol Scand. 2019 Jul;63(6):745-750. doi: 10.1111/aas.13346. Epub 2019 Mar 14.

PMID: 30869169

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  1. DAN plays important compensatory roles in systemic-to-pulmonary shunt associated pulmonary arterial hypertension.

Meng L, Liu X, Teng X, Yuan W, Duan L, Meng J, Li J, Zheng Z, Wei Y, Hu S.

Acta Physiol (Oxf). 2019 Jul;226(3):e13263. doi: 10.1111/apha.13263. Epub 2019 Feb 27.

PMID: 30715799

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  1. A Case of Dextrotransposition of the Great Arteries Type I with Reversed Differential Cyanosis.

Morimoto Y, Inamura N, Takemura T.

AJP Rep. 2019 Jul;9(3):e235-e237. doi: 10.1055/s-0039-1692421. Epub 2019 Jul 24.

PMID: 31360611 Free PMC Article

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  1. Clinical and molecular spectrum of CHOPS syndrome.

Raible SE, Mehta D, Bettale C, Fiordaliso S, Kaur M, Medne L, Rio M, Haan E, White SM, Cusmano-Ozog K, Nishi E, Guo Y, Wu H, Shi X, Zhao Q, Zhang X, Lei Q, Lu A, He X, Okamoto N, Miyake N, Piccione J, Allen J, Matsumoto N, Pipan M, Krantz ID, Izumi K.

Am J Med Genet A. 2019 Jul;179(7):1126-1138. doi: 10.1002/ajmg.a.61174. Epub 2019 May 6.

PMID: 31058441

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  1. Updates in Congenital Heart Disease: Can Outcomes Improve?

Martin GR, Cross RR, Hom LA, Klugman D.

Am J Perinatol. 2019 Jul;36(S 02):S22-S28. doi: 10.1055/s-0039-1691773. Epub 2019 Jun 25.

PMID: 31238354

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  1. Risk factors associated with the development of double-inlet ventricle congenital heart disease.

Paige SL, Yang W, Priest JR, Botto LD, Shaw GM, Collins RT 2nd; National Birth Defects Prevention Study.

Birth Defects Res. 2019 Jul 1;111(11):640-648. doi: 10.1002/bdr2.1501. Epub 2019 Mar 28.

PMID: 30920163

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  1. Point-of-care hemostasis in children with congenital heart disease, the POCHEMO study: baseline reference values of thromboelastometry and impedance aggregometry.

Longchamp D, Perez MH, Natterer J, Amiet V, Ferry T, Boegli Y, Mauron S, Dolci M, Plaza Wuthrich S, Di Bernardo S.

Blood Coagul Fibrinolysis. 2019 Jul;30(5):199-204. doi: 10.1097/MBC.0000000000000818.

PMID: 31157681

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  1. Newborn With Prenatal Diagnosis of Complex Congenital Heart Disease and DiGeorge Syndrome.

Khan AA, Schmitt C, Pridjian G, Dunbar AE, Yang SG.

Clin Pediatr (Phila). 2019 Jul;58(8):931-934. doi: 10.1177/0009922819846564. Epub 2019 May 3. No abstract available.

PMID: 31046438

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  1. Corrigendum to “Haemodynamic impacts of myocardial bridge length: A congenital heart disease” [Comput. Methods Progr. Biomed., 175 (2019) 25-33].

Javadzadegan A, Moshfegh A, Mohammadi M, Askarian M, Mohammadi M.

Comput Methods Programs Biomed. 2019 Jul;175:243. doi: 10.1016/j.cmpb.2019.04.011. Epub 2019 Apr 18.

PMID: 31109446

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  1. Haemodynamic impacts of myocardial bridge length: A congenital heart disease.

Javadzadegan A, Moshfegh A, Mohammadi M, Askarian M, Mohammadi M.

Comput Methods Programs Biomed. 2019 Jul;175:25-33. doi: 10.1016/j.cmpb.2019.03.017. Epub 2019 Mar 28. Erratum in: Comput Methods Programs Biomed. 2019 Jul;175:243.

PMID: 31104712

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  1. Relationship between pulmonary artery acceleration time and pulmonary artery pressures in infants.

Gaulton JS, Mercer-Rosa LM, Glatz AC, Jensen EA, Capone V, Scott C, Appel SM, Stoller JZ, Fraga MV.

Echocardiography. 2019 Jul 1. doi: 10.1111/echo.14430. [Epub ahead of print]

PMID: 31260138

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  1. A case report on endarteritis in a child with coarctation of aorta.

Gnanam D, Bartelds B, van Leeuwen WJ, Frohn-Mulder IM, Koopman LP.

Echocardiography. 2019 Jul;36(7):1427-1430. doi: 10.1111/echo.14418. Epub 2019 Jun 25.

PMID: 31237036

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  1. Ostium primum atrial septal defect with persistent left superior vena cava opening into unroofed coronary sinus-A rare entity.

Garg A, Agrawal D, Mishra D, Sharma GL.

Echocardiography. 2019 Jul;36(7):1421-1422. doi: 10.1111/echo.14408. Epub 2019 Jun 19.

PMID: 31215689

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  1. Comparative proteomic analysis of plasma of children with congenital heart disease.

Huang Q, Geng Z, Chen T, Cheng X, Gu H, Li Q, Li D, Liu R.

Electrophoresis. 2019 Jul;40(14):1848-1854. doi: 10.1002/elps.201900098. Epub 2019 May 14.

PMID: 31070245

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  1. Correlation between pri-miR-124 (rs531564) polymorphism and congenital heart disease susceptibility in Chinese population at two different altitudes: a case-control and in silico study.

Yang W, Yi K, Yu H, Ding Y, Li D, Wei Y, You T, Xie X.

Environ Sci Pollut Res Int. 2019 Jul;26(21):21983-21992. doi: 10.1007/s11356-019-05350-4. Epub 2019 May 29.

PMID: 31144180

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  1. Liver disease secondary to congenital heart disease in children.

Komatsu H, Inui A, Kishiki K, Kawai H, Yoshio S, Osawa Y, Kanto T, Fujisawa T.

Expert Rev Gastroenterol Hepatol. 2019 Jul;13(7):651-666. doi: 10.1080/17474124.2019.1621746. Epub 2019 May 26.

PMID: 31131680

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  1. Microcirculatory Differences in Children With Congenital Heart Disease According to Cyanosis and Age.

González R, Urbano J, Solana MJ, Hervías M, Pita A, Pérez R, Álvarez R, Teigell E, Gil-Jaurena JM, Zamorano J, Sobrino A, López-Herce J.

Front Pediatr. 2019 Jul 1;7:264. doi: 10.3389/fped.2019.00264. eCollection 2019.

PMID: 31312623 Free PMC Article

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  1. Creation of the Fontan circulation in sheep: a survival model.

Van Puyvelde J, Rega F, Minami T, Claus P, Cools B, Gewillig M, Meyns B.

Interact Cardiovasc Thorac Surg. 2019 Jul 1;29(1):15-21. doi: 10.1093/icvts/ivz022.

PMID: 30789218

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  1. Repeatability and Reproducibility of Neonatal Echocardiography: The Copenhagen Baby Heart Study.

Sillesen AS, Pihl C, Raja AA, Davidsen AS, Lind LE, Dannesbo S, Navne J, Raja R, Vejlstrup N, Lange T, Bundgaard H, Iversen K.

J Am Soc Echocardiogr. 2019 Jul;32(7):895-905.e2. doi: 10.1016/j.echo.2019.02.015. Epub 2019 May 7.

PMID: 31076139

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  1. Cardiovascular profile and biophysical profile scores predict short-term prognosis in infants with congenital heart defect.

Miyoshi T, Katsuragi S, Neki R, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Yoshimatsu J, Ikeda T.

J Obstet Gynaecol Res. 2019 Jul;45(7):1268-1276. doi: 10.1111/jog.13970. Epub 2019 Apr 11.

PMID: 30977251

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  1. Development of a System to Measure and Improve Outcomes in Congenital Heart Disease: Heart Institute Safety, Quality, and Value Program.

Clarke-Myers K, Cooper DS, Hanke SP, Storey J, McDonald M, Kimball TR, Anderson JB.

Jt Comm J Qual Patient Saf. 2019 Jul;45(7):495-501. doi: 10.1016/j.jcjq.2019.04.003. Epub 2019 May 31.

PMID: 31160230 Free Article

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  1. Simultaneous 3D whole-heart bright-blood and black blood imaging for cardiovascular anatomy and wall assessment with interleaved T2 prep-IR.

Milotta G, Ginami G, Cruz G, Neji R, Prieto C, Botnar RM.

Magn Reson Med. 2019 Jul;82(1):312-325. doi: 10.1002/mrm.27734. Epub 2019 Mar 21.

PMID: 30896049

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  1. E-learning or lectures to increase knowledge about congenital heart disease in infants: A comparative interventional study.

Hjorth-Johansen E, Hofoss D, Kynø NM.

Nurs Open. 2019 Jul 1;6(3):1143-1149. doi: 10.1002/nop2.317. eCollection 2019 Jul.

PMID: 31367440 Free PMC Article

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  1. Socio-economic inequalities in mortality in children with congenital heart disease: A systematic review and meta-analysis.

Best KE, Vieira R, Glinianaia SV, Rankin J.

Paediatr Perinat Epidemiol. 2019 Jul;33(4):291-309. doi: 10.1111/ppe.12564. Review.

PMID: 31347722

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Select item 31372144

 

  1. Assessment of quality of life in pediatric patients with pulmonary hypertension.

Handler SS, Hallis BJ, Tillman KA, Krolikowski M, Kuhn EM, Kirkpatrick EC, Brosig CL.

Pulm Circ. 2019 Jul-Sep;9(3):2045894018822985. doi: 10.1177/2045894018822985. Epub 2018 Dec 18.

PMID: 30562156 Free PMC Article

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Select item 30177458

 

  1. Changes in Adrenoceptor and GRK Expression in Patients With Chronic Pulmonary Regurgitation.

Rodríguez-Serrano M, Rueda Soriano J, Buendía Fuentes F, Osa Sáez AM, Montó Guillot F, D’Ocon Navaza P, Aguero J, Oliver E, Serrano F, Martínez-Dolz L.

Rev Esp Cardiol (Engl Ed). 2019 Jul;72(7):569-576. doi: 10.1016/j.rec.2018.05.030. Epub 2018 Aug 10. English, Spanish.

PMID: 30104167

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Select item 31373449

 

  1. Pulmonary Vein Stenosis: Outcomes in Children With Congenital Heart Disease and Prematurity.

DiLorenzo MP, Santo A, Rome JJ, Zhang H, Faerber JA, Mercer-Rosa L, Hopper RK.

Semin Thorac Cardiovasc Surg. 2019 Summer;31(2):266-273. doi: 10.1053/j.semtcvs.2018.09.027. Epub 2018 Sep 29.

PMID: 30278272

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Select item 30194978

 

  1. Biatrial Remodeling in Patients with Cystic Fibrosis Running Title: Atrial Function in Cystic Fibrosis.

Dordevic A, Genger M, Schwarz C, Cuspidi C, Tahirovic E, Pieske B, Düngen HD, Tadic M.

J Clin Med. 2019 Jul 31;8(8). pii: E1141. doi: 10.3390/jcm8081141.

PMID: 31370249 Free Article

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Select item 31367954

 

  1. Decrease in Cerebral Oxygen Saturation During the 6-Minute Walk Test in Pediatric Pulmonary Arterial Hypertension.

Orgun LT, Öztürk Z, Canbeyli FH, Yapar D, Gücüyener K, Kula S.

Pediatr Cardiol. 2019 Jul 31. doi: 10.1007/s00246-019-02174-4. [Epub ahead of print]

PMID: 31367954

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Select item 31367953

 

  1. Talin and Kindlin as Integrin-Activating Proteins: Focus on the Heart.

Chen C, Manso AM, Ross RS.

Pediatr Cardiol. 2019 Jul 31. doi: 10.1007/s00246-019-02167-3. [Epub ahead of print]

PMID: 31367953

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Select item 31367952

 

  1. Chemotherapy-Induced Cardiotoxicity in Adolescent After Heart Transplant: Do Not Forget the Right Ventricle.

Salas-Mera D, Deiros-Bronte L, Uceda-Galiano Á, Mozo-Del Castillo Y, García-Guereta L, Gutiérrez-Larraya F.

Pediatr Cardiol. 2019 Jul 31. doi: 10.1007/s00246-019-02170-8. [Epub ahead of print]

PMID: 31367951

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Select item 31356135

 

  1. Wearable Biosensors in Pediatric Cardiovascular Disease.

Tandon A, de Ferranti SD.

Circulation. 2019 Jul 30;140(5):350-352. doi: 10.1161/CIRCULATIONAHA.119.038483. Epub 2019 Jul 29. No abstract available.

PMID: 31356135

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Select item 31006260

 

  1. Left ventricular functions in pediatric patients with ten years or more type 1 diabetes mellitus: Conventional echocardiography, tissue Doppler, and two-dimensional speckle tracking study.

Rakha S, Aboelenin HM.

Pediatr Diabetes. 2019 Jul 29. doi: 10.1111/pedi.12900. [Epub ahead of print]

PMID: 31355962

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Select item 31391773

 

  1. Ambulatory Blood Pressure Monitoring in Pediatrics.

Patel SS, Daniels SR.

Curr Hypertens Rep. 2019 Jul 26;21(9):71. doi: 10.1007/s11906-019-0976-1. Review.

PMID: 31350605

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  1. Familial Left Ventricular Non-Compaction Is Associated With a Rare p.V407I Variant in Bone Morphogenetic Protein 10.

Hirono K, Saito K, Munkhsaikhan U, Xu F, Wang C, Lu L, Ichida F, Towbin JA, Purevjav E.

Circ J. 2019 Jul 25;83(8):1737-1746. doi: 10.1253/circj.CJ-19-0116. Epub 2019 Jun 26.

PMID: 31243186 Free Article

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Select item 31343842

 

  1. Defects in Trabecular Development Contribute to Left Ventricular Noncompaction.

Choquet C, Kelly RG, Miquerol L.

Pediatr Cardiol. 2019 Jul 24. doi: 10.1007/s00246-019-02161-9. [Epub ahead of print]

PMID: 31342111

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Select item 31348901

 

  1. Decrease in the frequency of treatment for patent ductus arteriosus after implementation of consensus guidelines: a 15-year experience.

Pavageau L, Brion LP, Rosenfeld CR, Brown LS, Ramaciotti C, Burchfield PJ, Jaleel MA.

J Perinatol. 2019 Jul 23. doi: 10.1038/s41372-019-0432-8. [Epub ahead of print]

PMID: 31337852

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Select item 31338559

 

  1. Insights into Arch Vessel Development in the Bovine Aortic Arch.

Meyer AM, Turek JW, Froud J, Endelman LA, Cavanaugh NB, Torres JE, Ashwath R.

Pediatr Cardiol. 2019 Jul 22. doi: 10.1007/s00246-019-02156-6. [Epub ahead of print]

PMID: 31332468

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Select item 31328690

 

  1. Acute vasodilator testing: An opportunity to advance the precision care of pulmonary hypertension.

Cirulis MM, Jorgensen LO, Day RW.

Respir Med Case Rep. 2019 Jul 21;28:100911. doi: 10.1016/j.rmcr.2019.100911. eCollection 2019.

PMID: 31384547 Free PMC Article

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Select item 30946015

 

  1. Direct Oral Anticoagulants: Novel Approach for the Treatment of Thrombosis in Pediatric Patients?

Mikler J, Samoš M, Bolek T, Škorňová I, Stančiaková L, Staško J, Mokáň M.

Pediatr Cardiol. 2019 Jul 20. doi: 10.1007/s00246-019-02159-3. [Epub ahead of print] Review.

PMID: 31327027

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Select item 31325368

 

  1. Stem cells: will they cure pediatric heart failure?

Bernstein D.

Curr Opin Pediatr. 2019 Jul 17. doi: 10.1097/MOP.0000000000000801. [Epub ahead of print]

PMID: 31335749

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Select item 31335747

 

  1. Is Doppler echocardiography useful for estimating left ventricular filling pressures in pediatric heart transplant recipients?

Lunze FI, Narciso R, Gauvreau K, Blume ED, Colan SD, Singh TP.

Pediatr Transplant. 2019 Jul 16:e13543. doi: 10.1111/petr.13543. [Epub ahead of print]

PMID: 31313435

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Select item 31312887

 

  1. Kawasaki disease and immunodeficiencies in children: case reports and literature review.

Rivas-Larrauri F, Aguilar-Zanela L, Castro-Oteo P, Rosales-Hernandez LA, Otero-Mendoza F, López-Herrera G, Ordoñez-Ortega J, Garrido-García M, Yamazaki-Nakashimada MA.

Rheumatol Int. 2019 Jul 16. doi: 10.1007/s00296-019-04382-w. [Epub ahead of print] Review.

PMID: 31312887

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Select item 31267131

 

  1. Increased extracellular volume in the liver of pediatric Fontan patients.

de Lange C, Reichert MJE, Pagano JJ, Seed M, Yoo SJ, Broberg CS, Lam CZ, Grosse-Wortmann L.

J Cardiovasc Magn Reson. 2019 Jul 15;21(1):39. doi: 10.1186/s12968-019-0545-4.

PMID: 31303178 Free PMC Article

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Select item 31302712

 

  1. Double-orifice mitral valve associated and bicuspid aortic valve: forme fruste of Shone’s complex?

Yang LT, Foley TA, Eidem BW, Crestanello JA, Michelena HI.

Eur Heart J Cardiovasc Imaging. 2019 Jul 13. pii: jez195. doi: 10.1093/ehjci/jez195. [Epub ahead of print] No abstract available.

PMID: 31302682

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Select item 31302680

 

  1. The clinical value of proposed risk stratification tools in pediatric pulmonary arterial hypertension.

Haarman MG, Douwes JM, Ploegstra MJ, Roofthooft MTR, Vissia-Kazemier T, Hillege HL, Berger RMF.

Am J Respir Crit Care Med. 2019 Jul 12. doi: 10.1164/rccm.201902-0266LE. [Epub ahead of print] No abstract available.

PMID: 31298925

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Select item 31301000

 

  1. Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry “MYKKE”.

Schubert S, Opgen-Rhein B, Boehne M, Weigelt A, Wagner R, Müller G, Rentzsch A, Zu Knyphausen E, Fischer M, Papakostas K, Wiegand G, Ruf B, Hannes T, Reineker K, Kiski D, Khalil M, Steinmetz M, Fischer G, Pickardt T, Klingel K, Messroghli DR, Degener F; MYKKE consortium.

Pediatr Transplant. 2019 Jul 11:e13548. doi: 10.1111/petr.13548. [Epub ahead of print]

PMID: 31297930

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Select item 31302108

 

  1. Giant aortic aneurysm due to fibulin- 4 deficiency: case series.

Sülü A, Başpınar O, Şahin DA.

Turk Pediatri Ars. 2019 Jul 11;54(2):119-124. doi: 10.5152/TurkPediatriArs.2018.4658. eCollection 2019.

PMID: 31384147 Free PMC Article

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Select item 31384144

 

  1. A case of right aortic arch with isolated left innominate artery and global cerebral white matter atrophy.

Binka E, Sun LR, Gailloud P, Chiu JS.

Cardiol Young. 2019 Jul 10:1-3. doi: 10.1017/S1047951119001537. [Epub ahead of print]

PMID: 31288876

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Select item 31292610

 

  1. Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation.

van der Palen RLF, van der Bom T, Dekker A, Tsonaka R, van Geloven N, Kuipers IM, Konings TC, Rammeloo LAJ, Ten Harkel ADJ, Jongbloed MRM, Koolbergen DR, Mulder BJM, Hazekamp MG, Blom NA.

Heart. 2019 Jul 10. pii: heartjnl-2019-315157. doi: 10.1136/heartjnl-2019-315157. [Epub ahead of print]

PMID: 31292191 Free Article

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Select item 31395365

 

  1. Double drainage of pulmonary vein associated with atrial septal defect.

Yılmaz M, Ziadinov E, Aykan HH.

Asian Cardiovasc Thorac Ann. 2019 Jul 9:218492319863600. doi: 10.1177/0218492319863600. [Epub ahead of print] No abstract available.

PMID: 31288550

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Select item 31287038

 

  1. Persistence of right ventricular dysfunction and altered morphometry in asymptomatic preterm Infants through one year of age: Cardiac phenotype of prematurity.

Erickson CT, Patel MD, Choudhry S, Bisselou KS, Sekarski T, Craft M, Li L, Khuffash AE, Hamvas A, Kutty S, Singh GK, Levy PT.

Cardiol Young. 2019 Jul 9:1-9. doi: 10.1017/S1047951119001161. [Epub ahead of print]

PMID: 31287038

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Select item 31338355

 

  1. Clinical Course, Management, and Outcomes of Pediatric Takayasu Arteritis Initially Presenting with Hypertension: a 16-year overview.

Fan L, Zhang H, Cai J, Yang L, Wei D, Yu J, Fan J, Song L, Ma W, Lou Y.

Am J Hypertens. 2019 Jul 5. pii: hpz103. doi: 10.1093/ajh/hpz103. [Epub ahead of print]

PMID: 31278892

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Select item 31277592

 

  1. The morphogenesis and associated anomalous pulmonary venous drainage in sinus venosus defect.

Hsu HM, Chang YT, Su WJ, Chu JJ, Chang YS, Hwang MS.

Pediatr Neonatol. 2019 Jul 4. pii: S1875-9572(18)30150-5. doi: 10.1016/j.pedneo.2019.06.013. [Epub ahead of print]

PMID: 31362863

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Select item 31268349

 

  1. Pulmonary arteriovenous malformations in a patient with single ventricle and polysplenia syndrome.

Sakaki S, Hayashi T, Ono H.

BMJ Case Rep. 2019 Jul 2;12(7). pii: e229491. doi: 10.1136/bcr-2019-229491.

PMID: 31270088

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Select item 31269439

 

  1. Cardiomyopathy in Children: Classification and Diagnosis: A Scientific Statement From the American Heart Association.

Lipshultz SE, Law YM, Asante-Korang A, Austin ED, Dipchand AI, Everitt MD, Hsu DT, Lin KY, Price JF, Wilkinson JD, Colan SD.

Circulation. 2019 Jul 2;140(1):e9-e68. doi: 10.1161/CIR.0000000000000682. Epub 2019 May 28.

PMID: 31132865

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Select item 31266355

 

  1. Real-World Outcomes with Lomitapide Use in Paediatric Patients with Homozygous Familial Hypercholesterolaemia.

Ben-Omran T, Masana L, Kolovou G, Ariceta G, Nóvoa FJ, Lund AM, Bogsrud MP, Araujo M, Hussein O, Ibarretxe D, Sanchez-Hernández RM, Santos RD.

Adv Ther. 2019 Jul;36(7):1786-1811. doi: 10.1007/s12325-019-00985-8. Epub 2019 May 17.

PMID: 31102204

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Select item 31071505

 

  1. Right ventricular function in patients with pulmonary regurgitation with versus without tetralogy of Fallot.

Larios G, Yim D, Dragulescu A, Mertens L, Grosse-Wortmann L, Friedberg MK.

Am Heart J. 2019 Jul;213:8-17. doi: 10.1016/j.ahj.2019.03.012. Epub 2019 Apr 8.

PMID: 31071505

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Select item 31030969

 

  1. Risk factors associated with the development of double-inlet ventricle congenital heart disease.

Paige SL, Yang W, Priest JR, Botto LD, Shaw GM, Collins RT 2nd; National Birth Defects Prevention Study.

Birth Defects Res. 2019 Jul 1;111(11):640-648. doi: 10.1002/bdr2.1501. Epub 2019 Mar 28.

PMID: 30920163

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Select item 31157681

 

  1. Normal Pediatric Values of the Subcostal Tricuspid Annular Plane Systolic Excursion (S-TAPSE) and Its Value in Pediatric Pulmonary Hypertension.

Kurath-Koller S, Avian A, Cantinotti M, Burmas A, Grangl G, Schweintzger S, Gamillscheg A, Koestenberger M.

Can J Cardiol. 2019 Jul;35(7):899-906. doi: 10.1016/j.cjca.2019.01.019. Epub 2019 Feb 2.

PMID: 31292089

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Select item 31257569

 

  1. Relationship between pulmonary artery acceleration time and pulmonary artery pressures in infants.

Gaulton JS, Mercer-Rosa LM, Glatz AC, Jensen EA, Capone V, Scott C, Appel SM, Stoller JZ, Fraga MV.

Echocardiography. 2019 Jul 1. doi: 10.1111/echo.14430. [Epub ahead of print]

PMID: 31260138

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Select item 31237036

 

  1. A case report on endarteritis in a child with coarctation of aorta.

Gnanam D, Bartelds B, van Leeuwen WJ, Frohn-Mulder IM, Koopman LP.

Echocardiography. 2019 Jul;36(7):1427-1430. doi: 10.1111/echo.14418. Epub 2019 Jun 25.

PMID: 31237036

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Select item 31215692

 

  1. Native valve endocarditis due to Candida albicans in two children: Two new case reports.

Guner G, Bal ZS, Dogan E, Umit Z, Levent E, Hilmioglu Polat S, Ozkinay F, Kurugol Z.

Echocardiography. 2019 Jul;36(7):1401-1404. doi: 10.1111/echo.14406. Epub 2019 Jun 19.

PMID: 31215692

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Select item 31184776

 

  1. Confirmation of the role of pathogenic SMAD6 variants in bicuspid aortic valve-related aortopathy.

Luyckx I, MacCarrick G, Kempers M, Meester J, Geryl C, Rombouts O, Peeters N, Claes C, Boeckx N, Sakalihasan N, Jacquinet A, Hoischen A, Vandeweyer G, Van Lent S, Saenen J, Van Craenenbroeck E, Timmermans J, Duijnhouwer A, Dietz H, Van Laer L, Loeys B, Verstraeten A.

Eur J Hum Genet. 2019 Jul;27(7):1044-1053. doi: 10.1038/s41431-019-0363-z. Epub 2019 Feb 22.

PMID: 30796334

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Select item 31134320

 

  1. Liver disease secondary to congenital heart disease in children.

Komatsu H, Inui A, Kishiki K, Kawai H, Yoshio S, Osawa Y, Kanto T, Fujisawa T.

Expert Rev Gastroenterol Hepatol. 2019 Jul;13(7):651-666. doi: 10.1080/17474124.2019.1621746. Epub 2019 May 26.

PMID: 31131680

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Select item 30377306

 

  1. Aspernolide F, as a new cardioprotective butyrolactone against doxorubicin-induced cardiotoxicity.

El-Agamy DS, Ibrahim SRM, Ahmed N, Khoshhal S, Abo-Haded HM, Elkablawy MA, Aljuhani N, Mohamed GA.

Int Immunopharmacol. 2019 Jul;72:429-436. doi: 10.1016/j.intimp.2019.04.045.

PMID: 31030099

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Select item 30879937

 

  1. Aortic atresia with the interrupted aortic arch and an pulmonary-coronary fistula: the unique constellation for survival.

Malec E, Kleinerueschkamp F, Januszewska K.

Interact Cardiovasc Thorac Surg. 2019 Jul 1;29(1):159-160. doi: 10.1093/icvts/ivz002.

PMID: 30698779

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Select item 30724444

 

  1. Usefulness of midodrine in protein-losing enteropathy.

Weingarten AJ, Menachem JN, Smith CA, Frischhertz BP, Book WM.

J Heart Lung Transplant. 2019 Jul;38(7):784-787. doi: 10.1016/j.healun.2019.04.002. Epub 2019 Apr 15. No abstract available.

PMID: 31031017

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Select item 31256695

 

  1. Diagnosis of anomalous origin of the right coronary artery from the pulmonary artery by echocardiography.

Wu LP, Zhang YQ, Chen LJ, Liu YQ.

J Med Ultrason (2001). 2019 Jul;46(3):335-341. doi: 10.1007/s10396-019-00933-7. Epub 2019 Feb 21.

PMID: 30790093

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Select item 31006807

 

  1. Cardiovascular profile and biophysical profile scores predict short-term prognosis in infants with congenital heart defect.

Miyoshi T, Katsuragi S, Neki R, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Yoshimatsu J, Ikeda T.

J Obstet Gynaecol Res. 2019 Jul;45(7):1268-1276. doi: 10.1111/jog.13970. Epub 2019 Apr 11.

PMID: 30977251

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Select item 30853201

 

  1. [Psychomotor and Cognitive Development and Quality of Life in Children and Adolescents with Congenital Heart Defect].

Hövels-Gürich H.

Klin Padiatr. 2019 Jul;231(4):183-190. doi: 10.1055/a-0942-1756. Epub 2019 Jun 19. German.

PMID: 31216577

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Select item 31126897

 

  1. Palliative care and paediatric cardiology: current evidence and future directions.

Morell E, Moynihan K, Wolfe J, Blume ED.

Lancet Child Adolesc Health. 2019 Jul;3(7):502-510. doi: 10.1016/S2352-4642(19)30121-X. Epub 2019 May 21. Erratum in: Lancet Child Adolesc Health. 2019 May 24;:.

PMID: 31126897

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Select item 31160809

 

  1. Case 1: A Blueberry Muffin Rash Complicated by Cardiomyopathy.

Schiff AF, Supples SP, Walsh MJ, Russell TB, Pylipow ME.

Neoreviews. 2019 Jul;20(7):e409-e411. doi: 10.1542/neo.20-7-e409. No abstract available.

PMID: 31261107

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Select item 31041457

 

  1. Hypoplastic Left Heart Syndrome: An Overview for Primary Care Providers.

Javed R, Cetta F, Said SM, Olson TM, O’Leary PW, Qureshi MY.

Pediatr Rev. 2019 Jul;40(7):344-353. doi: 10.1542/pir.2018-0005.

PMID: 31263042

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Select item 30638136

 

  1. Assessment of quality of life in pediatric patients with pulmonary hypertension.

Handler SS, Hallis BJ, Tillman KA, Krolikowski M, Kuhn EM, Kirkpatrick EC, Brosig CL.

Pulm Circ. 2019 Jul-Sep;9(3):2045894018822985. doi: 10.1177/2045894018822985. Epub 2018 Dec 18.

PMID: 30562156 Free PMC Article

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Select item 30278272

 

  1. Parotitis coexisting with Kawasaki disease in a child: a rare presentation of Kawasaki disease.

Gökçe Ş, Uysal N, Erkmen H, Doğan E, Koç F.

Trop Doct. 2019 Jul;49(3):217-221. doi: 10.1177/0049475519829604. Epub 2019 Mar 21.

PMID: 30898051

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Select item 31021025

 

  1. Isolated Single Right Coronary Artery in a Pediatric Patient.

Berger JH, Rome JJ, Brothers JA.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):515-517. doi: 10.1177/2150135119842872.

PMID: 31307295

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Select item 31307293

 

ACHD Featured Articles in association with ISACHD

Adult Congenital Heart Reviews of July 2019 manuscripts (sponsored by ISACHD)

Planned vaginal delivery and cardiovascular morbidity in pregnant women with heart disease.
Easter SR, Rouse CE, Duarte V, Hynes JS, Singh MN, Landzberg MJ, Valente AM, Economy KE.
Am J Obstet Gynecol. 2019 Jul 13. pii: S0002-9378(19)30903-2. doi: 10.1016/j.ajog.2019.07.019. [Epub ahead of print]
PMID: 31310750
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Select item 31302712

Take Home Points:

• There was no significant difference in cardiac complication rates in patients with planned Caesarean section versus planned vaginal delivery in pregnant women with heart disease.
• The highest risk patients (aortic stenosis, Marfan’s) underwent planned Caesarean section or operative vaginal delivery.
• The complications rate was low across the board, so the study was statistically underpowered to detect a significant difference in cardiac complication rates between the two groups.

Commentary from Dr. Helen Parry (Leeds UK), section editor of ACHD Journal Watch: It is generally accepted that Caesarean section in mothers with heart disease is usually only indicated for obstetric reasons. However, a third of mothers with cardiovascular disease end up having a Caesarean delivery. It is also unclear whether operative vaginal delivery, designed to reduce time spent performing the Valsalva manoeuvre, actually increases rather than reduces maternal morbidity.

This was a prospective study at a single centre in Boston where patents were categorised according to pathology: congenital heart disease, valvular heart disease, cardiomyopathy, connective tissue disorder or vascular disease. They were regarded as high risk if they had 1 or more of:
• NYHA>II
• resting saturation <90%
• left ventricular ejection fraction <40%
• peak gradient through LVOT >30mmHg
• sub-pulmonic ventricular ejection fraction <40%
• aortic conditions associated with connective tissue disease

Patients were looked after by a multi-disciplinary team. Vaginal delivery was generally encouraged and patients were divided according to planned delivery mode. The primary endpoint was the development of cardiovascular complications including congestive heart failure, sustained arrhythmia, stroke, worsening valve function, endocarditis, aortic dissection, need for cardiac intervention, cardiac arrest or death. This included complications occurring up to 6 weeks post-partum.

The study enrolled 276 expectant mothers who ultimately delivered a baby. 210 of these were planned vaginal deliveries (70% of these women had congenital heart disease), 66 planned Caesarean (these patients had a greater proportion of left ventricular outflow tract obstruction, 65% of these patients had congenital heart disease). Eighty-six per cent of the patients with planned vaginal delivery went on to deliver vaginally although 9.5% of those had operative vaginal deliveries as pushing was limited in these patients due to aortic stenosis or Marfan’s. The remaining 14% of patients with planned vaginal delivery underwent Caesarean section for obstetric reasons. Rates of cardiac complications as defined above were similar between the 2 groups.

There were a number of study limitations including the small sample size of the planned Caesarean section group, the grouping together of all congenital heart disease and the single centre nature of the study raises questions about whether results are representative. The low cardiac complication rate in both groups means that the study was statistically under powered to detect a difference between the 2 groups.

Myocardial blood flow and cardiac sympathetic innervation in young adults late after arterial switch operation for transposition of the great arteries.
Possner M, Buechel RR, Vontobel J, Mikulicic F, Gräni C, Benz DC, Clerc OF, Fuchs TA, Tobler D, Stambach D, Greutmann M, Kaufmann PA.
Int J Cardiol. 2019 Jul 13. pii: S0167-5273(19)32420-9. doi: 10.1016/j.ijcard.2019.07.041. [Epub ahead of print]
PMID: 31337551
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Select item 30252328

Take Home Points:

• Disruption of cardiac sympathetic innervation occurs to a variable degree following the arterial switch operation.
• This small study sought to evaluate sympathetic innervation in young adults after the arterial switch procedure and assess myocardial blood flow at rest and during stress.
• The study group consisted of 12 patients (age 22.5 +/- 2.6 years) who previously underwent an arterial switch operation and 10 ‘normal’ control subjects (age 22 +/- 1.7 years).
• PET scanning assessed cardiac sympathetic innervation at rest and under stress.
• Patients with a previous arterial switch, compared to normal subjects had attenuated sympathetic innervation. Global myocardial blood flow during rest and stress was lower in ASO patients compared to control subjects.

Commentary from Dr Damien Cullington (Liverpool, United Kingdom), section editor of ACHD Journal Watch: The arterial switch operation (ASO) was first performed in 1975 by Jatene and superseded the atrial switch with ever increasing frequency from the 1980s. So far, outcomes are very good but, there are important issues which ever increasingly crop up, for example, the dimensional threshold at which to contemplate neo-aortic root replacement (where benefit >risk) and the risk stratification (how and with what frequency) of patients who have kinked re-implanted coronary arteries. Cardiac sympathetic fibres travel with the coronary arteries and the ASO often results in denervation which may consequently alter regulation of myocardial blood flow (MBF). Little has been studied about sympathetic innervation and MBF in adult patients who have undergone the ASO, hence the purpose of this study.

Assessment of sympathetic innervation and myocardial blood flow

On day one, myocardial blood flow was measured using [15O] H2O PET. Assessments were made at rest, after adenosine stress and following a cold pressor test. On day two, cardiac sympathetic innervation was measured using [11C] meta-hydroxyephedrine (mHED) PET. [11C] mHED is an analogue of norepinephrine – highly specific for pre-synaptic sympathetic nerve terminals. Coronary computed tomography angiography (using a 256 slice high resolution CT scanner) was performed in all patients after mHED PET. Full details of the analysis and calculation of MBF is found in the main text of the article.

Myocardial blood flow at rest and stress (Figure 1 and Table 1) and cardiac sympathetic innervation

MBF at rest and during adenosine stress was significantly lower in patients with ASO vs healthy controls. No difference in MBF was seen during the cold pressor test. Global [11C] mHED uptake was significantly lower in patients with ASO vs controls (p<0.001).

Figure 1 – Myocardial blood flow in healthy controls and patients after ASO at rest and during adenosine-induced hyperaemia (A) and at rest and during cold pressor test (B). Comparison of cold pressor test induced myocardial blood flow (C) and mHED uptake (D) between healthy controls and patients.

Conclusions

The ASO procedure leads to attenuated cardiac sympathetic innervation. MBF response to cold pressor testing did not differ between ASO patients or controls. This is a small study which confirms similar findings in children. Further, large observational studies are needed to assess the natural history and long terms outcomes of patients who undergo the ASO.

Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation.
van der Palen RLF, van der Bom T, Dekker A, Tsonaka R, van Geloven N, Kuipers IM, Konings TC, Rammeloo LAJ, Ten Harkel ADJ, Jongbloed MRM, Koolbergen DR, Mulder BJM, Hazekamp MG, Blom NA.
Heart. 2019 Jul 10. pii: heartjnl-2019-315157. doi: 10.1136/heartjnl-2019-315157. [Epub ahead of print]
PMID: 31292191 Free Article
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Select item 31289972

Take Home Points:

• Neo-aortic root dilatation and aortic incompetence in patients post ASO is progressive – does not stabilize over time.
• More complex subtypes of TGA and male gender were associated with greater increases in root dilatation.
• A disproportionate increase of aortic root size occurs in the first year post ASO.

Commentary from Dr. Blanche Cupido (Cape Town, South Africa), section editor of ACHD Journal Watch: The arterial switch operation (ASO) has largely replaced the atrial switch procedure for transposition of the great arteries (TGA) over the last 2 decades. The late survival with this procedure has been excellent but the concern of neo-aortic dilatation (in >2/3 of patients) and aortic regurgitation (AR) remains. There is however limited data, especially in adults, on the progression of neo-aortic dilatation.

This is a retrospective study from the Netherlands, describing neo-aortic growth, neo-aortic valve function and the need for neo-aortic root intervention at long term follow-up and to identify risk factors for root dilatation and AR.

All patients who underwent an ASO for TGA with intact ventricular septum (TGA-IVS), TGA with VSD (TGA-VSD) or double outlet RV with subpulmonary VSD (DORV-SP-VSD) between 1977 and 2015 were included. All patients had 2 or more echocardiograms during follow-up. If possible, echo images at 3,6,9 and 12 months and then at 2,3 and 5 years and 5 year intervals thereafter were evaluated until the last available follow-up. The following neo-aortic measurements were recorded: annulus, mid-sinus and sinotubular junction. For paediatric patients, Z scores were calculated and dilatation defined as a Z score of 2 or more. AR jet and LV dimensions were also assessed.

A total of 452 patients underwent ASO. Fifty-two patients (11.5%) patients died during follow-up of which 42 deaths occurred during the first month post-op. Early deaths were higher in the years 1977-1987, and reduced to 3.3% in subsequent years. The cohort was made up of the following morphological subtypes: TGA-IVS (66.7%), TGA-VSD (25.8%) and DORV-SP-VSD (7.5%).

Figure 2A-C above shows the absolute neo-aortic diameters for all patients with TGA. The dimensions for neo-aortic annulus, root and STJ shows a rapid increase in the first year post- ASO followed by a linear increase in childhood and an ongoing increased growth rate in adulthood. For neo-aortic annulus and root diameters, both TGA-VSD and DORV-PS-VSD showed significantly greater dilatation compared to TGA-IVS. Both morphological subtype and male gender were independent predictors for root dilatation.

Regarding aortic regurgitation, at last follow-up or just before re-operation for root pathology, 33 patients (9.6%) had at least moderate AR.

 

More than the heart: Hepatic, renal, and cardiac dysfunction in adult Fontan patients.
Byrne RD, Weingarten AJ, Clark DE, Huang S, Perri RE, Scanga AE, Menachem JN, Markham LW, Frischhertz BP.
Congenit Heart Dis. 2019 Jul 7. doi: 10.1111/chd.12820. [Epub ahead of print]
PMID: 31282062
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Select item 31282223

Take Home Points:

• MELD and MELD-XI are scoring systems used to assess the severity of chronic liver disease.
• Systolic ventricular dysfunction and decreased oxygen saturation were associated with hepatic and renal dysfunction which were shown by an increase in MELD and MELD-XI scores and creatinine level.

Commentary from Dr. M.C. Leong (Kuala Lumpur, Indonesia), section editor of ACHD Journal Watch: The Model for End-Stage Liver Disease (MELD) is a scoring system used to assess the severity of chronic liver disease by using the patient’s serum bilirubin, serum creatinine and the international normalized ratio (INR). It is used originally to predict survival of patients and to decide for liver transplant in patients post transjugular intrahepatic porto-systemic shunt (TIPS) procedure.

MELD = (3.78 × ln[total serum bilirubin (mg/dL)]) + (11.2 × ln[INR]) + (9.57 × ln[serum creatinine (mg/dL)]) + 6.43.

A modified scoring systemic named MELD-XI, which omits INR from its equation, has been used to correlate the impact of failing Fontan and hepatic fibrosis. The reason behind omitting INR from the equation was due to the high prevalence of Warfarin use in patients with Fontan.

MELD‐XI = (11.76 × ln[serum creatinine (mg/dL)]) + (5.11 × ln[total serum bilirubin(mg/dL)]) + 9.44.

This study aimed to investigate the association between MELD and MELD-XI; and Fontan circuit congestion and dysfunction in 98 patients post-Fontan (age 15 years or older). Of the hemodynamic variable analyzed, decreased oxygen saturation and moderate to severe reduction in ejection fraction, measured via echocardiography, were associated with increased MELD and MELD-XI scores as well as increased creatinine levels. Age at Fontan, systemic ventricular morphology, degree of atrio-ventricular valve regurgitation and Fontan pressures were not associated with elevated MELD, MELD-XI scores and creatinine levels.

MELD and MELD-XI scores still lack evidence to link its association with failing Fontan. Also, they may be useful as surrogate biochemical markers to monitor hepatic fibrosis patients with Fontan circulation but not as a tool to predict the risk of Fontan associated liver disease. Nevertheless, it may present as a good biochemical marker to complement the already available monitoring tools.

 

ACHD July 2019

 

  1. A genetic model for multimorbidity in young adults.

Malecki SL, Van Mil S, Graffi J, Breetvelt E, Corral M, Boot E, Chow EWC, Sanches M, Verma AA, Bassett AS.

Genet Med. 2019 Jul 31. doi: 10.1038/s41436-019-0603-1. [Epub ahead of print]

PMID: 31363180

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Select item 31367952

 

  1. Knowledge of Life-Long Cardiac Care by Adolescents and Young Adults with Congenital Heart Disease.

Fernandes SM, Verstappen A, Clair M, Rummell M, Barber D, Ackerman K, Dummer K, Mares JC, Cannobio MM, Reardon LC, Long J, Crumb S, Bhatt A, Takahashi M, Khairy P, Williams R, Landzberg MJ, Moe T, Pearson D; Adult Congenital Heart Association and the Adult Congenital Cardiac Care Associate Research Group.

Pediatr Cardiol. 2019 Jul 31. doi: 10.1007/s00246-019-02154-8. [Epub ahead of print]

PMID: 31367952

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Select item 31365573

 

  1. A model for geographic and sociodemographic access to care disparities for adults with congenital heart disease.

Salciccioli KB, Oluyomi A, Lupo PJ, Ermis PR, Lopez KN.

Congenit Heart Dis. 2019 Jul 30. doi: 10.1111/chd.12819. [Epub ahead of print]

PMID: 31361081

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Select item 31361302

 

  1. Increased epicardial adipose tissue in young adults with congenital heart disease comorbid with major depressive disorder.

Kahl KG, Fraccarollo D, Winter L, Bauersachs J, Westhoff-Bleck M.

J Affect Disord. 2019 Jul 30;257:678-683. doi: 10.1016/j.jad.2019.07.070. [Epub ahead of print]

PMID: 31377604

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Select item 31365456

 

  1. Hypertrophic cardiomyopathy: New hope for an old disease.

Larkin G, Bellomo T, Caze L.

Nursing. 2019 Jul 30. doi: 10.1097/01.NURSE.0000577688.41805.80. [Epub ahead of print]

PMID: 31365456

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Select item 31355951

 

  1. Diagnostic evaluation of the hospital depression scale (HADS) and the Beck depression inventory II (BDI-II) in adults with congenital heart disease using a structured clinical interview: Impact of depression severity.

Westhoff-Bleck M, Winter L, Aguirre Davila L, Herrmann-Lingen C, Treptau J, Bauersachs J, Bleich S, Kahl KG.

Eur J Prev Cardiol. 2019 Jul 26:2047487319865055. doi: 10.1177/2047487319865055. [Epub ahead of print]

PMID: 31349778

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Select item 31350277

 

  1. Heart failure risk predictions in adult patients with congenital heart disease: a systematic review.

Wang F, Harel-Sterling L, Cohen S, Liu A, Brophy JM, Paradis G, Marelli AJ.

Heart. 2019 Jul 26. pii: heartjnl-2019-314977. doi: 10.1136/heartjnl-2019-314977. [Epub ahead of print] Review.

PMID: 31350277

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Select item 31350568

 

  1. Right ventricular failure in congenital heart disease.

Friedberg MK, Reddy S.

Curr Opin Pediatr. 2019 Jul 25. doi: 10.1097/MOP.0000000000000804. [Epub ahead of print]

PMID: 31356354

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Select item 31342289

 

  1. Maternal Mortality in the United States and the HOPE Registry.

Grodzinsky A, Florio K, Spertus JA, Daming T, Schmidt L, Lee J, Rader V, Nelson L, Gray R, White D, Swearingen K, Magalski A.

Curr Treat Options Cardiovasc Med. 2019 Jul 25;21(9):42. doi: 10.1007/s11936-019-0745-0. Review.

PMID: 31342274

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Select item 31352143

 

  1. Ready for Transfer to Adult Care? A Triadic Evaluation of Transition Readiness in Adolescents With Congenital Heart Disease and Their Parents.

Burström Å, Acuña Mora M, Öjmyr-Joelsson M, Sparud-Lundin C, Rydberg A, Hanseus K, Frenckner B, Nisell M, Moons P, Bratt EL.

J Fam Nurs. 2019 Jul 25:1074840719864255. doi: 10.1177/1074840719864255. [Epub ahead of print]

PMID: 31342815

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Select item 31377271

 

  1. [Analysis of hemodynamics and outcomes of pregnant women with congenital heart disease-pulmonary arterial hypertension].

Zhang LL, Zhang J.

Zhonghua Fu Chan Ke Za Zhi. 2019 Jul 25;54(7):438-444. doi: 10.3760/cma.j.issn.0529-567x.2019.07.002. Chinese.

PMID: 31365955

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Select item 31348032

 

  1. Utilization of echocardiography in Ehlers-Danlos syndrome.

Rauser-Foltz KK, Starr LJ, Yetman AT.

Congenit Heart Dis. 2019 Jul 22. doi: 10.1111/chd.12824. [Epub ahead of print]

PMID: 31328377

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Select item 31328339

 

  1. Adult Congenital Heart Disease – Australia and New Zealand: A Call for Optimal Care.

Menahem S.

Heart Lung Circ. 2019 Jul 22. pii: S1443-9506(19)31351-4. doi: 10.1016/j.hlc.2019.06.722. [Epub ahead of print] No abstract available.

PMID: 31383544

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Select item 31343584

 

  1. Exercise Training in Adults With Congenital Heart Disease: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Li X, Chen N, Zhou X, Yang Y, Chen S, Song Y, Sun K, Du Q.

J Cardiopulm Rehabil Prev. 2019 Jul 22. doi: 10.1097/HCR.0000000000000420. [Epub ahead of print]

PMID: 31343584

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Select item 31255560

 

  1. Healthcare transition for adolescents and young adults with long-term conditions: Qualitative study of patients, parents and healthcare professionals’ experiences.

Coyne I, Sheehan A, Heery E, While AE.

J Clin Nurs. 2019 Jul 20. doi: 10.1111/jocn.15006. [Epub ahead of print]

PMID: 31327174

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Select item 31321886

 

  1. Denoising and artefact removal for transthoracic echocardiographic imaging in congenital heart disease: utility of diagnosis specific deep learning algorithms.

Diller GP, Lammers AE, Babu-Narayan S, Li W, Radke RM, Baumgartner H, Gatzoulis MA, Orwat S.

Int J Cardiovasc Imaging. 2019 Jul 19. doi: 10.1007/s10554-019-01671-0. [Epub ahead of print]

PMID: 31325067

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Select item 31325066

 

  1. Left atrial enlargement as a maker of significant high-risk patent foramen ovale.

Rigatelli G, Zuin M, Adami A, Aggio S, Lanza D, d’Elia K, Braggion G, Russo M, Mazza A, Roncon L.

Int J Cardiovasc Imaging. 2019 Jul 19. doi: 10.1007/s10554-019-01666-x. [Epub ahead of print]

PMID: 31325066

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Select item 31319891

 

  1. Hemodynamically balanced congenitally corrected transposition of the great arteries with a large ventricular septal defect, and subvalvular pulmonic stenosis: a case report.

Cho SY, Yoon YE, Lee W, Kang SH, Song YH, Lim C, Cho GY, Seo JW.

J Med Case Rep. 2019 Jul 19;13(1):219. doi: 10.1186/s13256-019-2145-1.

PMID: 31319891 Free PMC Article

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Select item 31322092

 

  1. Mediating effects of exercise capacity on the association between physical activity and health-related quality of life among adolescents with complex congenital heart disease.

Kim HJ, Jae SY, Choo J, Yoon JK, Kim SH, Königstein K, Schmidt-Trucksäss A, Franklin BA.

Am J Hum Biol. 2019 Jul 18:e23297. doi: 10.1002/ajhb.23297. [Epub ahead of print]

PMID: 31321831

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Select item 31341792

 

  1. Intracardiac 4D Flow MRI in Congenital Heart Disease: Recommendations on Behalf of the ISMRM Flow & Motion Study Group.

Zhong L, Schrauben EM, Garcia J, Uribe S, Grieve SM, Elbaz MSM, Barker AJ, Geiger J, Nordmeyer S, Marsden A, Carlsson M, Tan RS, Garg P, Westenberg JJM, Markl M, Ebbers T.

J Magn Reson Imaging. 2019 Jul 17. doi: 10.1002/jmri.26858. [Epub ahead of print]

PMID: 31317587

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Select item 31311582

 

  1. Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot.

Yamamura K, Sakamoto I, Morihana E, Hirata Y, Nagata H, Yamasaki Y, Okumura Y, Kohashi K, Koto K, Tsutsui H, Ohga S.

Int J Cardiol. 2019 Jul 15;287:121-126. doi: 10.1016/j.ijcard.2019.04.032. Epub 2019 Apr 11.

PMID: 31006598

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Select item 31003793

 

  1. Right ventricular pressure overload alters cardiac lipid composition.

Koop AMC, Hagdorn QAJ, Bossers GPL, van Leusden T, Gerding A, van Weeghel M, Vaz FM, Koonen DPY, Silljé HHW, Berger RMF, Bartelds B.

Int J Cardiol. 2019 Jul 15;287:96-105. doi: 10.1016/j.ijcard.2019.04.004. Epub 2019 Apr 8.

PMID: 31003793

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Select item 30712848

 

  1. Novel collaborative cardiology and maternal fetal medicine practice – experience at the heart and pregnancy program.

Bettin M, Louis-Jacques A, Romagano MP, Cabrera I, Ahnert A, Freudenberger R, Quiñones JN.

J Matern Fetal Neonatal Med. 2019 Jul 15:1-6. doi: 10.1080/14767058.2019.1640207. [Epub ahead of print]

PMID: 31269843

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Select item 31311125

 

  1. Planned vaginal delivery and cardiovascular morbidity in pregnant women with heart disease.

Easter SR, Rouse CE, Duarte V, Hynes JS, Singh MN, Landzberg MJ, Valente AM, Economy KE.

Am J Obstet Gynecol. 2019 Jul 13. pii: S0002-9378(19)30903-2. doi: 10.1016/j.ajog.2019.07.019. [Epub ahead of print]

PMID: 31310750

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Select item 31302712

 

  1. Validation of simple measures of aortic distensibility based on standard 4-chamber cine CMR: a new approach for clinical studies.

Stoiber L, Ghorbani N, Kelm M, Kuehne T, Rank N, Lapinskas T, Stehning C, Pieske B, Falk V, Gebker R, Kelle S.

Clin Res Cardiol. 2019 Jul 13. doi: 10.1007/s00392-019-01525-8. [Epub ahead of print]

PMID: 31302712

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Select item 31302680

 

  1. Myocardial blood flow and cardiac sympathetic innervation in young adults late after arterial switch operation for transposition of the great arteries.

Possner M, Buechel RR, Vontobel J, Mikulicic F, Gräni C, Benz DC, Clerc OF, Fuchs TA, Tobler D, Stambach D, Greutmann M, Kaufmann PA.

Int J Cardiol. 2019 Jul 13. pii: S0167-5273(19)32420-9. doi: 10.1016/j.ijcard.2019.07.041. [Epub ahead of print]

PMID: 31337551

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Select item 30252328

 

  1. Long-term outcomes in adults with repaired tetralogy of Fallot and pulmonary atresia.

Egbe AC, Crestanello J, Dearani JA, Osman K, Banala K, Angirekula M, Najam M, Ammash NM.

Cardiol Young. 2019 Jul 10:1-4. doi: 10.1017/S1047951119001598. [Epub ahead of print]

PMID: 31288878

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Select item 31290594

 

  1. Congenitally corrected transposition of the great arteries in a 69-year-old woman.

Ancel-Tallal C, Dubourg B, Barre E, Michelin P, Dacher JN.

Diagn Interv Imaging. 2019 Jul 10. pii: S2211-5684(19)30161-5. doi: 10.1016/j.diii.2019.06.008. [Epub ahead of print] No abstract available.

PMID: 31302072

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Select item 31292607

 

  1. Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation.

van der Palen RLF, van der Bom T, Dekker A, Tsonaka R, van Geloven N, Kuipers IM, Konings TC, Rammeloo LAJ, Ten Harkel ADJ, Jongbloed MRM, Koolbergen DR, Mulder BJM, Hazekamp MG, Blom NA.

Heart. 2019 Jul 10. pii: heartjnl-2019-315157. doi: 10.1136/heartjnl-2019-315157. [Epub ahead of print]

PMID: 31292191 Free Article

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Select item 31289972

 

  1. Evaluation of 4D flow MRI-based non-invasive pressure assessment in aortic coarctations.

Saitta S, Pirola S, Piatti F, Votta E, Lucherini F, Pluchinotta F, Carminati M, Lombardi M, Geppert C, Cuomo F, Figueroa CA, Xu XY, Redaelli A.

J Biomech. 2019 Jul 9. pii: S0021-9290(19)30444-0. doi: 10.1016/j.jbiomech.2019.07.004. [Epub ahead of print]

PMID: 31326119

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Select item 31287192

 

  1. More than the heart: Hepatic, renal, and cardiac dysfunction in adult Fontan patients.

Byrne RD, Weingarten AJ, Clark DE, Huang S, Perri RE, Scanga AE, Menachem JN, Markham LW, Frischhertz BP.

Congenit Heart Dis. 2019 Jul 7. doi: 10.1111/chd.12820. [Epub ahead of print]

PMID: 31282062

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Select item 31282223

 

  1. The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation.

Koski TK, Suominen PK, Raissadati A, Knihtilä HM, Ojala TH, Salminen JT.

Acta Anaesthesiol Scand. 2019 Jul 4. doi: 10.1111/aas.13431. [Epub ahead of print]

PMID: 31271655

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Select item 31272943

 

  1. Cardiopulmonary exercise testing and sports participation in adults with congenital heart disease.

Buber J, Shafer K.

Heart. 2019 Jul 4. pii: heartjnl-2018-313928. doi: 10.1136/heartjnl-2018-313928. [Epub ahead of print] No abstract available.

PMID: 31273028

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Select item 31371115

 

  1. A single-centre, placebo-controlled, double-blind randomised cross-over study of nebulised iloprost in patients with Eisenmenger syndrome: A pilot study.

Nashat H, Kempny A, Harries C, Dormand N, Alonso-Gonzalez R, Price LC, Gatzoulis MA, Dimopoulos K, Wort SJ.

Int J Cardiol. 2019 Jul 4. pii: S0167-5273(19)31450-0. doi: 10.1016/j.ijcard.2019.07.004. [Epub ahead of print]

PMID: 31371115

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Select item 31279999

 

  1. Risk of Cancer Among Children and Young Adults With Congenital Heart Disease Compared With Healthy Controls.

Mandalenakis Z, Karazisi C, Skoglund K, Rosengren A, Lappas G, Eriksson P, Dellborg M.

JAMA Netw Open. 2019 Jul 3;2(7):e196762. doi: 10.1001/jamanetworkopen.2019.6762.

PMID: 31276179

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Select item 31276174

 

  1. Increasing Evidence for and a Word of Caution About an Association Between Cancer and Congenital Heart Disease.

Gurvitz M.

JAMA Netw Open. 2019 Jul 3;2(7):e196756. doi: 10.1001/jamanetworkopen.2019.6756. No abstract available.

PMID: 31276174

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Select item 31279540

 

  1. Prognostic Importance and Predictors of Survival in Isolated Tricuspid Regurgitation: A Growing Problem.

Fender EA, Petrescu I, Ionescu F, Zack CJ, Pislaru SV, Nkomo VT, Cochuyt JJ, Hodge DO, Nishimura RA.

Mayo Clin Proc. 2019 Jul 3. pii: S0025-6196(19)30467-7. doi: 10.1016/j.mayocp.2019.04.036. [Epub ahead of print]

PMID: 31279540

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Select item 31266026

 

  1. Assessment of liver T1 mapping in fontan patients and its correlation with magnetic resonance elastography-derived liver stiffness.

Ramachandran P, Serai SD, Veldtman GR, Lang SM, Mazur W, Trout AT, Dillman JR, Fleck RJ, Taylor MD, Alsaied T, Moore RA.

Abdom Radiol (NY). 2019 Jul;44(7):2403-2408. doi: 10.1007/s00261-019-01990-9.

PMID: 30903232

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Select item 30266547

 

  1. Surveillance of Congenital Heart Defects among Adolescents at Three U.S. Sites.

Lui GK, McGarry C, Bhatt A, Book W, Riehle-Colarusso TJ, Dunn JE, Glidewell J, Gurvitz M, Hoffman T, Hogue CJ, Hsu D, Obenhaus S, Raskind-Hood C, Rodriguez FH 3rd, Zaidi A, Van Zutphen AR.

Am J Cardiol. 2019 Jul 1;124(1):137-143. doi: 10.1016/j.amjcard.2019.03.044. Epub 2019 Apr 10.

PMID: 31030970 Free Article

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Select item 31030969

 

  1. Perceived Health Mediates Effects of Physical Activity on Quality of Life in Patients With a Fontan Circulation.

Holbein CE, Veldtman GR, Moons P, Kovacs AH, Luyckx K, Apers S, Chidambarathanu S, Soufi A, Eriksen K, Jackson JL, Enomoto J, Fernandes SM, Johansson B, Alday L, Dellborg M, Berghammer M, Menahem S, Caruana M, Kutty S, Mackie AS, Thomet C, Budts W, White K, Sluman MA, Callus E, Cook SC, Khairy P, Cedars A; APPROACH-IS consortium and the International Society for Adult Congenital Heart Disease (ISACHD).

Am J Cardiol. 2019 Jul 1;124(1):144-150. doi: 10.1016/j.amjcard.2019.03.039. Epub 2019 Apr 10.

PMID: 31030969

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Select item 31058441

 

  1. Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence.

van der Feen DE, Berger RMF, Bartelds B.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):11-20. doi: 10.1165/rcmb.2018-0329TR.

PMID: 30758225

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Select item 31267159

 

  1. Maternal and fetal outcomes in pregnancies complicated by the inherited aortopathy Loeys-Dietz syndrome.

Cauldwell M, Steer PJ, Curtis S, Mohan AR, Dockree S, Mackillop L, Parry H, Oliver J, Sterrenburg M, Bolger A, Siddiqui F, Simpson M, Walker N, Bredaki F, Walker F, Johnson MR.

BJOG. 2019 Jul;126(8):1025-1031. doi: 10.1111/1471-0528.15670. Epub 2019 Apr 1.

PMID: 30811810

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Select item 31157681

 

  1. Predicting 15-Year Mortality in Adults With Congenital Heart Disease Using Disease Severity and Functional Indices.

Ombelet F, Goossens E, Apers S, Budts W, Gewillig M, Moons P.

Can J Cardiol. 2019 Jul;35(7):907-913. doi: 10.1016/j.cjca.2019.04.018. Epub 2019 Apr 26.

PMID: 31292090

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Select item 31292078

 

  1. The Complex Relationship That Is RV-PA Coupling and Its Relevance to Managing Congenital Heart Disease.

Sathananthan G, Grewal J.

Can J Cardiol. 2019 Jul;35(7):816-818. doi: 10.1016/j.cjca.2019.04.027. Epub 2019 May 10. No abstract available.

PMID: 31292078

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Select item 31044297

 

  1. Evaluation and Management of the Child and Adult With Fontan Circulation: A Scientific Statement From the American Heart Association.

Rychik J, Atz AM, Celermajer DS, Deal BJ, Gatzoulis MA, Gewillig MH, Hsia TY, Hsu DT, Kovacs AH, McCrindle BW, Newburger JW, Pike NA, Rodefeld M, Rosenthal DN, Schumacher KR, Marino BS, Stout K, Veldtman G, Younoszai AK, d’Udekem Y; American Heart Association Council on Cardiovascular Disease in the Young and Council on Cardiovascular and Stroke Nursing.

Circulation. 2019 Jul 1:CIR0000000000000696. doi: 10.1161/CIR.0000000000000696. [Epub ahead of print]

PMID: 31256636

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Select item 31046438

 

  1. Association between cardiovascular autonomic neuropathy and left ventricular hypertrophy in young patients with congenital generalized lipodystrophy.

Ponte CMM, Fernandes VO, Liberato CBR, Montenegro APDR, Batista LA, Gurgel MHC, de Azevedo Karbage LB, Vasconcelos ITGF, d’Alva CB, Montenegro Júnior RM.

Diabetol Metab Syndr. 2019 Jul 1;11:53. doi: 10.1186/s13098-019-0444-8. eCollection 2019.

PMID: 31303898 Free PMC Article

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Select item 31260138

 

  1. Fistula between the right pulmonary artery and the left atrium coexisting with a secundum-type atrial septal defect: An unusual case of cyanosis in a girl.

Zhang WM, Zhu HX, Maimaitiaili A, Ayibieke N, Ermek T, Liu J, Zhang ZG, Li SG.

Echocardiography. 2019 Jul;36(7):1423-1426. doi: 10.1111/echo.14414. Epub 2019 Jun 19.

PMID: 31215690

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Select item 31215689

 

  1. The 10th Euro-GUCH/ACHD Meeting.

Gatzoulis MA, Subira LD, Roos-Hesselink JW, Budts W, Brida M.

Eur Heart J. 2019 Jul 1;40(25):1996-1998. doi: 10.1093/eurheartj/ehz417. No abstract available.

PMID: 31259375

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Select item 30886339

 

  1. Copy number variation analysis in bicuspid aortic valve-related aortopathy identifies TBX20 as a contributing gene.

Luyckx I, Kumar AA, Reyniers E, Dekeyser E, Vanderstraeten K, Vandeweyer G, Wünnemann F, Preuss C, Mazzella JM, Goudot G, Messas E, Albuisson J, Jeunemaitre X, Eriksson P, Mohamed SA, Kempers M, Salemink S, Duijnhouwer A, Andelfinger G, Dietz HC, Verstraeten A, Van Laer L, Loeys BL; MIBAVA Leducq Consortium.

Eur J Hum Genet. 2019 Jul;27(7):1033-1043. doi: 10.1038/s41431-019-0364-y. Epub 2019 Feb 28.

PMID: 30820038

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Select item 30971116

 

  1. Peripartum outcomes in a large population of women with pulmonary arterial hypertension associated with congenital heart disease.

Li Q, Dimopoulos K, Liu T, Xu Z, Liu Q, Li Y, Zhang J, Gu H.

Eur J Prev Cardiol. 2019 Jul;26(10):1067-1076. doi: 10.1177/2047487318821246. Epub 2019 Apr 11.

PMID: 30971116

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Select item 30717604

 

  1. Pregnancy still contraindicated in pulmonary arterial hypertension related to congenital heart disease: True or false?

Ntiloudi D, Giannakoulas G.

Eur J Prev Cardiol. 2019 Jul;26(10):1064-1066. doi: 10.1177/2047487318825347. Epub 2019 Feb 4. No abstract available.

PMID: 30717604

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Select item 31131680

 

  1. Intracardiac mass in a 66-year-old woman.

Zhang W, Pei F, Wan J.

Heart. 2019 Jul;105(14):1062-1128. doi: 10.1136/heartjnl-2018-314600. Epub 2019 Mar 28. No abstract available.

PMID: 30923174

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Select item 30862643

 

  1. sST2: a new kid on the block for patients with ACHD.

Tutarel O.

Heart. 2019 Jul;105(13):972. doi: 10.1136/heartjnl-2019-314699. Epub 2019 Mar 12. No abstract available.

PMID: 30862643

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Select item 30772822

 

  1. Atrial septal defect closure in adulthood is associated with normal survival in the mid to longer term.

Brida M, Diller GP, Kempny A, Drakopoulou M, Shore D, A Gatzoulis M, Uebing A.

Heart. 2019 Jul;105(13):1014-1019. doi: 10.1136/heartjnl-2018-314380. Epub 2019 Jan 31.

PMID: 30705053

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Select item 30700520

 

  1. Prognostic value of soluble ST2 in adults with congenital heart disease.

Geenen LW, Baggen VJM, van den Bosch AE, Eindhoven JA, Cuypers JAAE, Witsenburg M, Boersma E, Roos-Hesselink JW.

Heart. 2019 Jul;105(13):999-1006. doi: 10.1136/heartjnl-2018-314168. Epub 2019 Jan 30.

PMID: 30700520 Free PMC Article

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Select item 31079695

 

  1. Right ventricular mechanical pattern in health and disease: beyond longitudinal shortening.

Kovács A, Lakatos B, Tokodi M, Merkely B.

Heart Fail Rev. 2019 Jul;24(4):511-520. doi: 10.1007/s10741-019-09778-1. Review.

PMID: 30852772 Free PMC Article

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Select item 31263905

 

  1. [Medical care of adults with congenital heart diseases : Present and future].

Neidenbach R, Achenbach S, Andonian C, Beckmann J, Biber S, Dittrich S, Ewert P, Freilinger S, Huntgeburth M, Nagdyman N, Oberhoffer R, Pieper L, von Kodolitsch Y, Weyand M, Bauer UMM, Kaemmerer H.

Herz. 2019 Jul 1. doi: 10.1007/s00059-019-4820-9. [Epub ahead of print] German.

PMID: 31263905

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Select item 30954286

 

  1. Aortopathy and regurgitation in bicuspid valve patients increase the risk of aortopathy in relatives.

Dayan V, Zuasnabar A, Citro R, Bossone E, Michelena HI, Parma G, Bellino M, Olascoaga A, Florio L, Body S; Bicuspid Aortic Valve Consortium – BAVCON.

Int J Cardiol. 2019 Jul 1;286:117-120. doi: 10.1016/j.ijcard.2019.03.031. Epub 2019 Mar 18.

PMID: 30954286

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Select item 30409740

 

  1. Subtraction of time-resolved magnetic resonance angiography images improves visualization of the pulmonary veins and left atrium in adults with congenital heart disease: a novel post-processing technique.

Sugrue G, Cradock A, McGee A, McEntee C, Eustace SK, Fitzpatrick P, Lawler LP, Murray JG.

Int J Cardiovasc Imaging. 2019 Jul;35(7):1339-1346. doi: 10.1007/s10554-019-01585-x. Epub 2019 Apr 4.

PMID: 30949869

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Select item 31220277

 

  1. A right coronary artery aneurysm 16 years after surgical repair of anomalous origin of the right coronary artery from the pulmonary artery.

Furutachi A, Furukawa K, Komatsu A, Nogami E.

Interact Cardiovasc Thorac Surg. 2019 Jul 1;29(1):157-158. doi: 10.1093/icvts/ivy356.

PMID: 30689918

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Select item 30635953

 

  1. The Prognostic Value of Myocardial Deformation in Adult Patients With Corrected Tetralogy of Fallot.

van Grootel RWJ, van den Bosch AE, Baggen VJM, Menting ME, Baart SJ, Cuypers JAAE, Witsenburg M, Roos-Hesselink JW.

J Am Soc Echocardiogr. 2019 Jul;32(7):866-875.e2. doi: 10.1016/j.echo.2019.03.014. Epub 2019 May 4.

PMID: 31064677

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Select item 31231081

 

  1. Sarcopenia in adults with congenital heart disease: Nutritional status, dietary intake, and resistance training.

Shiina Y, Matsumoto N, Okamura D, Takahashi Y, Kijima Y, Fukuda T, Kawamatsu N, Nishihata Y, Komiyama N, Niwa K.

J Cardiol. 2019 Jul;74(1):84-89. doi: 10.1016/j.jjcc.2019.01.003. Epub 2019 Jan 31.

PMID: 30713126

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Select item 31262322

 

  1. An overview of the molecular mechanisms underlying development and progression of bicuspid aortic valve disease.

Balistreri CR, Forte M, Greco E, Paneni F, Cavarretta E, Frati G, Sciarretta S.

J Mol Cell Cardiol. 2019 Jul;132:146-153. doi: 10.1016/j.yjmcc.2019.05.013. Epub 2019 May 17. Review.

PMID: 31103478

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Select item 31071333

 

  1. [Psychomotor and Cognitive Development and Quality of Life in Children and Adolescents with Congenital Heart Defect].

Hövels-Gürich H.

Klin Padiatr. 2019 Jul;231(4):183-190. doi: 10.1055/a-0942-1756. Epub 2019 Jun 19. German.

PMID: 31216577

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Select item 30887492

 

  1. Pattern of un-operated Grown Up Congenital Heart (GUCH) patients presenting to a Tertiary Care Cardiac Institute of Punjab.

Mughal AR, Tousif R, Alamgir AR, Jalal A.

Pak J Med Sci. 2019 Jul-Aug;35(4):1066-1071. doi: 10.12669/pjms.35.4.878.

PMID: 31372144 Free PMC Article

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Select item 30925574

 

  1. Noonan Syndrome Case Report: PTPN11 and Other Potential Genetic Factors Contributing to Lethal Hypertrophic Right Ventricular Cardiomyopathy.

Daoud E, Zwick D.

Pediatr Dev Pathol. 2019 Jul-Aug;22(4):386-390. doi: 10.1177/1093526618825411. Epub 2019 Jan 21.

PMID: 30665336

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Select item 31107995

 

  1. Tissue oxygen saturation assessment of microvascular perfusion in adults with Fontan palliation and comparator groups using vascular optical spectrophotometry: a pilot study.

Agarwal R, Chaudhry B, Jansen K, O’Sullivan J, Hudson M, Allen J, Coats L.

Physiol Meas. 2019 Jul 1;40(6):06NT01. doi: 10.1088/1361-6579/ab1f1c.

PMID: 31051474

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Select item 30562156

 

  1. [A quadricuspid aortic valve passed unnoticed].

Bouziane M, Marchetta S, Dulgheru RE, Lancellotti P.

Rev Med Liege. 2019 Jul;74(7-8):378-381. French.

PMID: 31373449

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Select item 30616005

 

  1. Stress increases intracardiac 4D flow cardiovascular magnetic resonance -derived energetics and vorticity and relates to VO2max in Fontan patients.

Kamphuis VP, Elbaz MSM, van den Boogaard PJ, Kroft LJM, Lamb HJ, Hazekamp MG, Jongbloed MRM, Blom NA, Helbing WA, Roest AAW, Westenberg JJM.

J Cardiovasc Magn Reson. 2019 Jul 25;21(1):43. doi: 10.1186/s12968-019-0553-4.

PMID: 31340834 Free PMC Article

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Select item 31346664

 

  1. Differential Myocardial Mechanics in Volume and Pressure Loaded Right Ventricles Demonstrated by Cardiac Magnetic Resonance.

Wu K, Yu S, Dorfman AL, Lowery R, Agarwal PP, Ghadimi Mahani M, Lu JC.

Pediatr Cardiol. 2019 Jul 25. doi: 10.1007/s00246-019-02175-3. [Epub ahead of print]

PMID: 31346663

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  1. Late Survival and Patient-Perceived Health Status of the CHSS dextro-Transposition of the Great Arteries Cohort.

Devlin PJ, Jegatheeswaran A, Williams WG, Blackstone EH, DeCampli WM, Lambert LM, Mussatto KA, Prospero CJ, Bondarenko I, McCrindle BW.

Ann Thorac Surg. 2019 Jul 23. pii: S0003-4975(19)31050-1. doi: 10.1016/j.athoracsur.2019.05.081. [Epub ahead of print]

PMID: 31348901

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Select item 31331409

 

  1. Predicting the pressure of the total cavopulmonary connection: clinical testing of a mathematical equation.

Di Molfetta A, Iacobelli R, Rotella S, Gagliardi MG, Amodeo A, Formigari R, Pasquini L, Iorio SF, Guccione P.

Cardiol Young. 2019 Jul 23:1-6. doi: 10.1017/S1047951119001513. [Epub ahead of print]

PMID: 31331409

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Select item 31331407

 

  1. Utilization of echocardiography in Ehlers-Danlos syndrome.

Rauser-Foltz KK, Starr LJ, Yetman AT.

Congenit Heart Dis. 2019 Jul 22. doi: 10.1111/chd.12824. [Epub ahead of print]

PMID: 31328377

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Select item 31335745

 

  1. Treatment of pediatric pulmonary arterial hypertension: A focus on the NO-sGC-cGMP pathway.

Beghetti M, Gorenflo M, Ivy DD, Moledina S, Bonnet D.

Pediatr Pulmonol. 2019 Jul 16. doi: 10.1002/ppul.24442. [Epub ahead of print] Review.

PMID: 31313530

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Select item 31313435

 

  1. Emergence and Characterization of Acute Coronary Syndrome in Adults After Confirmed or Missed History of Kawasaki Disease in Japan: A Japanese Nationwide Survey.

Mitani Y, Tsuda E, Kato H, Higaki T, Fujiwara M, Ogawa S, Satoh F, Nakamura Y, Takahashi K, Ayusawa M, Kobayashi T, Ichida F, Matsushima M, Kamada M, Suda K, Ohashi H, Sawada H, Komatsu T, Waki K, Shinoda M, Tsunoda R, Yokoi H, Hamaoka K.

Front Pediatr. 2019 Jul 9;7:275. doi: 10.3389/fped.2019.00275. eCollection 2019.

PMID: 31338354 Free PMC Article

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Select item 31300312

 

  1. The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation.

Koski TK, Suominen PK, Raissadati A, Knihtilä HM, Ojala TH, Salminen JT.

Acta Anaesthesiol Scand. 2019 Jul 4. doi: 10.1111/aas.13431. [Epub ahead of print]

PMID: 31271655

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Select item 31279788

 

  1. Normal basic 2D echocardiographic values to screen and follow up the athlete’s heart from juniors to adults: What is known and what is missing. A critical review.

Cantinotti M, Koestenberger M, Santoro G, Assanta N, Franchi E, Paterni M, Iervasi G, D’Andrea A, D’Ascenzi F, Giordano R, Galderisi M.

Eur J Prev Cardiol. 2019 Jul 2:2047487319862060. doi: 10.1177/2047487319862060. [Epub ahead of print]

PMID: 31266355

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Select item 31312624

 

 

  1. Perceived Health Mediates Effects of Physical Activity on Quality of Life in Patients With a Fontan Circulation.

Holbein CE, Veldtman GR, Moons P, Kovacs AH, Luyckx K, Apers S, Chidambarathanu S, Soufi A, Eriksen K, Jackson JL, Enomoto J, Fernandes SM, Johansson B, Alday L, Dellborg M, Berghammer M, Menahem S, Caruana M, Kutty S, Mackie AS, Thomet C, Budts W, White K, Sluman MA, Callus E, Cook SC, Khairy P, Cedars A; APPROACH-IS consortium and the International Society for Adult Congenital Heart Disease (ISACHD).

Am J Cardiol. 2019 Jul 1;124(1):144-150. doi: 10.1016/j.amjcard.2019.03.039. Epub 2019 Apr 10.

PMID: 31030969

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Select item 31259625

 

  1. Tornado-like flow in the Fontan circulation: insights from quantification and visualization of viscous energy loss rate using 4D flow MRI.

Rijnberg FM, van Assen HC, Hazekamp MG, Roest AAW.

Eur Heart J. 2019 Jul 1;40(26):2170. doi: 10.1093/eurheartj/ehz160. No abstract available.

PMID: 30916327

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Select item 30753614

 

  1. Peripartum outcomes in a large population of women with pulmonary arterial hypertension associated with congenital heart disease.

Li Q, Dimopoulos K, Liu T, Xu Z, Liu Q, Li Y, Zhang J, Gu H.

Eur J Prev Cardiol. 2019 Jul;26(10):1067-1076. doi: 10.1177/2047487318821246. Epub 2019 Apr 11.

PMID: 30971116

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Select item 31131680

 

  1. Altered brain diffusion tensor imaging indices in adolescents with the Fontan palliation.

Singh S, Roy B, Pike N, Daniel E, Ehlert L, Lewis AB, Halnon N, Woo MA, Kumar R.

Neuroradiology. 2019 Jul;61(7):811-824. doi: 10.1007/s00234-019-02208-x. Epub 2019 Apr 30.

PMID: 31041457

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Select item 31034616

 

  1. Pattern of un-operated Grown Up Congenital Heart (GUCH) patients presenting to a Tertiary Care Cardiac Institute of Punjab.

Mughal AR, Tousif R, Alamgir AR, Jalal A.

Pak J Med Sci. 2019 Jul-Aug;35(4):1066-1071. doi: 10.12669/pjms.35.4.878.

PMID: 31372144 Free PMC Article

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ACHD Electrophysiology Featured Articles

Congenital and Pediatric Cardiac EP Reviews of July 2019 Manuscripts

 

The entirely subcutaneous ICDTM system in patients with congenital heart disease: experience from a large single-centre analysis.

Willy K, Reinke F, Bögeholz N, Köbe J, Eckardt L, Frommeyer G.

Europace. 2019 Jul 13. pii: euz190. doi: 10.1093/europace/euz190. [Epub ahead of print]

PMID: 31302706

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Take Home Points:  

  • ACHD patients who are not candidates for transvenous systems (i.e. cyanotic or single ventricular heart disease) are overrepresented in cohorts of ACHD SICD studies such as this one.
  • The SICD appears to be effective and safe in the ACHD population, with an acceptable rate of inappropriate shocks during short term follow up.
  • The long-term outcome of ACHD patients undergoing SICD placement is not well-described and larger studies are still needed. 

Commentary by Dr. Jeremy Moore (Los Angeles) Congenital and Pediatric Cardiac EP section editor:  This was a single-center retrospective study evaluating the authors’ experience with the SICD in 20 patients with adult congenital heart disease. The first SICD was implanted at this center in June 2010, shortly after the CE mark approval in Europe. The mean age was 40.5 ± 11.5 years and the youngest patient was 19 years of age. The SICDs were implanted in a heterogenous population of ACHD patients, however at least 5 (25%) patients had single ventricle anatomy and 3 (15%) were palliated and/or cyanotic. Device implantation was most commonly secondary prevention in 70% and primary prevention in 30%. Only one patient had a preexisting cardiac device at the time of implant. Acute testing was notable for successful defibrillation in 18 of 20 at 65J, one at 70J, and deferred in one.

 The study follow up period was 3 years, during which time 3 (15%) patients experienced appropriate shocks and 2 (10%) experienced inappropriate shocks (IAS). Appropriate shocks for monomorphic VT were observed in one TOF and one DTGA-Mustard patient, and multiple appropriate shocks for polymorphic VT were observed in a patient with HLHS who had undergone a TCPC operation. IAS were due to T wave oversensing in both cases, and could be avoided with programming changes (i.e. One managed by changing the sensing vector, the other by turning on SMARTPASS filter). During follow up, 3 patients died from non-arrhythmic causes. One system required explantation for wound infection that could not be treated with antibiotics. 

Although this is not the largest study of the SICD in ACHD to date, this report benefits from nearly complete data acquisition and relatively long follow up, compared to other similar studies. Overall, this report supports the SICD as a useful technological strategy for ACHD patients, particularly those with single ventricle anatomy or cyanotic congenital heart disease as demonstrated previously.1 As opposed to other similar studies in this population, issues such as concomitant cardiac electronic devices (common in the Fontan population) and IAS were less commonly seen. As for the latter, recent improvements in this technology such as improvements in bandpass filtering, may partially explain this discrepancy. Also, the absence of unprotected brady-asystole was not observed in this study, which is encouraging (although implanters should remain vigilant for this possibility).

  1. Moore JP, Mondésert B, Lloyd MS, Cook SC, Zaidi AN, Pass RH, John AS, Fish FA, Shannon KM, Aboulhosn JA, Khairy P; Alliance for Adult Research in Congenital Cardiology (AARCC). Clinical Experience with the Subcutaneous Implantable Cardioverter-Defibrillator in Adults with Congenital Heart Disease. Circ Arrhythm Electrophysiol. 2016 Sep;9(9). pii: e004338. doi: 10.1161/CIRCEP.116.004338.

 

CHD EP July 2019

  1. Diagnostic and Therapeutic Approach to Arrhythmias in Adult Congenital Heart Disease.

Guerrier K, Hendrickson B, Waller BR, Wetzel GT.

Curr Treat Options Cardiovasc Med. 2019 Jul 25;21(9):44. doi: 10.1007/s11936-019-0749-9. Review.

PMID: 31342289

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  1. Catheter Ablation Of Supraventricular Tachycardia After Tricuspid Valve Surgery In Patients With Congenital Heart Disease: A Multicenter Comparative Study.

Moore JP, Gallotti RG, Chiriac A, McLeod CJ, Stephenson EA, Maghrabi K, Fish FA, Kilinc OU, Bradley D, Krause U, Balaji S, Shannon KM.

Heart Rhythm. 2019 Jul 23. pii: S1547-5271(19)30661-7. doi: 10.1016/j.hrthm.2019.07.020. [Epub ahead of print]

PMID: 31349063

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Select item 31332841

 

  1. Detection of arrhythmias in adult congenital heart disease patients with LINQTM implantable loop recorder.

Dodeja AK, Thomas C, Daniels CJ, Kertesz N, Kamp A.

Congenit Heart Dis. 2019 Jul 16. doi: 10.1111/chd.12815. [Epub ahead of print]

PMID: 31313513

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Select item 31313661

 

  1. Atrial fibrillation in adults with congenital heart disease.

Waldmann V, Laredo M, Abadir S, Mondésert B, Khairy P.

Int J Cardiol. 2019 Jul 15;287:148-154. doi: 10.1016/j.ijcard.2019.01.079. Epub 2019 Jan 26. Review.

PMID: 30712848

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Select item 31269843

 

  1. The entirely subcutaneous ICDTM system in patients with congenital heart disease: experience from a large single-centre analysis.

Willy K, Reinke F, Bögeholz N, Köbe J, Eckardt L, Frommeyer G.

Europace. 2019 Jul 13. pii: euz190. doi: 10.1093/europace/euz190. [Epub ahead of print]

PMID: 31302706

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Select item 31302722

 

  1. Significance of automated external defibrillator in identifying lethal ventricular arrhythmias.

Tsuda T, Geary EM, Temple J.

Eur J Pediatr. 2019 Jul 11. doi: 10.1007/s00431-019-03421-9. [Epub ahead of print]

PMID: 31297625

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Select item 31326488

 

  1. CMR for Identifying the Substrate of Ventricular Arrhythmia in Patients With Normal Echocardiography.

Andreini D, Dello Russo A, Pontone G, Mushtaq S, Conte E, Perchinunno M, Guglielmo M, Coutinho Santos A, Magatelli M, Baggiano A, Zanchi S, Melotti E, Fusini L, Gripari P, Casella M, Carbucicchio C, Riva S, Fassini G, Li Piani L, Fiorentini C, Bartorelli AL, Tondo C, Pepi M.

JACC Cardiovasc Imaging. 2019 Jul 11. pii: S1936-878X(19)30561-3. doi: 10.1016/j.jcmg.2019.04.023. [Epub ahead of print]

PMID: 31326488

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Select item 31305328

 

  1. Postoperative and short-term atrial tachyarrhythmia burdens after transcatheter vs surgical pulmonary valve replacement among congenital heart disease patients.

Wadia SK, Lluri G, Aboulhosn JA, Laks H, Biniwale RM, Van Arsdell GS, Levi DS, Salem MM, Shannon KM, Moore JP.

Congenit Heart Dis. 2019 Jul 7. doi: 10.1111/chd.12818. [Epub ahead of print]

PMID: 31282099

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Select item 31282062

 

  1. Effects of maternal medication on long-term outcome in congenital heart block remain to be established. Response to: ‘Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero’ by Satis et al.

Mofors J, Sonesson SE, Wahren-Herlenius M.

Ann Rheum Dis. 2019 Jul 4. pii: annrheumdis-2019-215677. doi: 10.1136/annrheumdis-2019-215677. [Epub ahead of print] No abstract available.

PMID: 31272943

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Select item 31279788

 

  1. PREVENTION-ACHD: PRospEctiVE study on implaNTable cardioverter-defibrillator therapy and suddeN cardiac death in Adults with Congenital Heart Disease; Rationale and Design.

Vehmeijer JT, Koyak Z, Zwinderman AH, Harris L, Peinado R, Oechslin EN, Silversides CK, Bouma BJ, Budts W, van Gelder IC, Oliver JM, Mulder BJM, de Groot JR.

Neth Heart J. 2019 Jul 3. doi: 10.1007/s12471-019-1297-3. [Epub ahead of print]

PMID: 31270738

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Select item 31354955

 

  1. Intravenous antazoline, a first-generation antihistaminic drug with antiarrhythmic properties, is a suitable agent for pharmacological cardioversion of atrial fibrillation induced during pulmonary vein isolation due to the lack of influence on atrio-venous conduction and high clinical effectiveness (AntaEP Study).

Farkowski MM, Maciag A, Kowalik I, Konka M, Szwed H, Pytkowski M.

Br J Clin Pharmacol. 2019 Jul;85(7):1552-1558. doi: 10.1111/bcp.13940. Epub 2019 May 23.

PMID: 30920001

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Select item 31292090

 

  1. Risk of Atrial Fibrillation in Patients with Congenital Heart Disease: Results of a Propensity Score-Matched, Nationwide Cohort Study.

Hu WS, Lin CL.

J Atheroscler Thromb. 2019 Jul 1;26(7):670-677. doi: 10.5551/jat.48835. Epub 2019 Jun 22.

PMID: 31231081 Free PMC Article

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Select item 30713126

 

  1. Complex Congenital Heart Malformation Including Transposition of the Great Vessels, Presenting as Sudden Unexplained Infant Death.

Demeter CN, Gunther WM, Fantaskey AP.

J Forensic Sci. 2019 Jul;64(4):1241-1244. doi: 10.1111/1556-4029.13967. Epub 2018 Nov 28.

PMID: 30485421

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Select item 31006521

 

  1. Association Between Postoperative Dexmedetomidine Use and Arrhythmias in Infants After Cardiac Surgery.

Ortmann LA, Keshary M, Bisselou KS, Kutty S, Affolter JT.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):440-445. doi: 10.1177/2150135119842873.

PMID: 31307294

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Select item 31142197

 

  1. Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children.

Khera R, Tang Y, Girotra S, Nadkarni VM, Link MS, Raymond TT, Guerguerian AM, Berg RA, Chan PS; American Heart Association’s Get With the Guidelines-Resuscitation Investigators.

Circulation. 2019 Jul 30;140(5):370-378. doi: 10.1161/CIRCULATIONAHA.118.039048. Epub 2019 Apr 22.

PMID: 31006260

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Select item 31366035

 

  1. Specific Therapy Based on the Genotype in a Malignant Form of Long QT3, Carrying the V411M Mutation.

Blich M, Khoury A, Suleiman M, Lorber A, Gepstein L, Boulous M.

Int Heart J. 2019 Jul 27;60(4):979-982. doi: 10.1536/ihj.18-705. Epub 2019 Jun 28.

PMID: 31257342 Free Article

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Select item 31352491

 

  1. Transcriptional and Epigenetic Regulation of Cardiac Electrophysiology.

Jimenez J, Rentschler SL.

Pediatr Cardiol. 2019 Jul 25. doi: 10.1007/s00246-019-02160-w. [Epub ahead of print]

PMID: 31346662

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Select item 31342118

 

  1. Pediatric-Onset Arrhythmogenic Cardiomyopathy: Look Right, Look Left, Look Both Ways.

Ackerman MJ, Giudicessi JR.

J Am Coll Cardiol. 2019 Jul 23;74(3):359-361. doi: 10.1016/j.jacc.2019.05.023. No abstract available.

PMID: 31319918

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Select item 31319917

 

  1. Phenotypic Manifestations of Arrhythmogenic Cardiomyopathy in Children and Adolescents.

DeWitt ES, Chandler SF, Hylind RJ, Beausejour Ladouceur V, Blume ED, VanderPluym C, Powell AJ, Fynn-Thompson F, Roberts AE, Sanders SP, Bezzerides V, Lakdawala NK, MacRae CA, Abrams DJ.

J Am Coll Cardiol. 2019 Jul 23;74(3):346-358. doi: 10.1016/j.jacc.2019.05.022.

PMID: 31319917

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Select item 31338525

 

  1. Severe bradycardia probably associated to Oseltamivir in a pediatric patient with acute renal injury.

Castellano-Martinez A, Rodriguez-Gonzalez M.

Enferm Infecc Microbiol Clin. 2019 Jul 17. pii: S0213-005X(19)30192-2. doi: 10.1016/j.eimc.2019.05.010. [Epub ahead of print] English, Spanish. No abstract available.

PMID: 31326238

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Select item 31315938

 

  1. QT prolongation in patients with acute leukemia or high-risk myelodysplastic syndrome prescribed antifungal prophylaxis during chemotherapy-induced neutropenia.

Barreto JN, Cullen MW, Mara KC, Grove ME, Sierzchulski AG, Dahl NJ, Tosh PK, Dierkhising RA, Patnaik MM, Ackerman MJ.

Leuk Lymphoma. 2019 Jul 12:1-9. doi: 10.1080/10428194.2019.1639165. [Epub ahead of print]

PMID: 31298598

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Select item 31336875

 

  1. Normal electrocardiogram values of healthy children.

Uygur Ö, Aydoğdu A.

Turk Pediatri Ars. 2019 Jul 11;54(2):93-104. doi: 10.14744/TurkPediatriArs.2019.04568. eCollection 2019.

PMID: 31384144 Free PMC Article

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Select item 31290383

 

  1. Catheter Ablation of Ventricular Arrhythmias Originating From the Pulmonary Sinus Cusp in Pediatric Patients: A Single-Center Retrospective Study.

Liu T, Liang D, Liao Z, Zhang Z, Wang S, Zeng S.

Front Pediatr. 2019 Jul 9;7:280. doi: 10.3389/fped.2019.00280. eCollection 2019.

PMID: 31338355 Free PMC Article

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  1. Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from SABRUS.

Milman A, Andorin A, Postema PG, Gourraud JB, Sacher F, Mabo P, Kim SH, Maeda S, Takahashi Y, Kamakura T, Aiba T, Conte G, Juang JJM, Leshem E, Michowitz Y, Fogelman R, Hochstadt A, Mizusawa Y, Giustetto C, Arbelo E, Huang Z, Corrado D, Delise P, Allocca G, Takagi M, Wijeyeratne YD, Mazzanti A, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Sarquella-Brugada G, Jespersen CH, Tfelt-Hansen J, Veltmann C, Priori SG, Behr ER, Yan GX, Brugada J, Gaita F, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B.

Heart Rhythm. 2019 Jul 5. pii: S1547-5271(19)30635-6. doi: 10.1016/j.hrthm.2019.07.003. [Epub ahead of print]

PMID: 31284050

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  1. Demographic and clinical features of pediatric patients with orthostatic intolerance and an abnormal head-up tilt table test; A retrospective descriptive study.

Gourishankar A, Belton MD, Hashmi SS, Butler IJ, Lankford JE, Numan MT.

Pediatr Neonatol. 2019 Jul 5. pii: S1875-9572(18)30713-7. doi: 10.1016/j.pedneo.2019.06.012. [Epub ahead of print]

PMID: 31387844

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  1. Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.

Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ.

J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2.

PMID: 31264976 Free Article

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Select item 31353104

 

  1. Successful Ablation of Ventricular Tachycardia in Repaired Tetralogy of Fallot via Transjugular and Subclavian Approach.

Chuang CM, Chung FP, Lee PC, Chen SA.

Acta Cardiol Sin. 2019 Jul;35(4):433-436. doi: 10.6515/ACS.201907_35(4).20190320A. No abstract available.

PMID: 31371906 Free PMC Article

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Select item 30276861

 

  1. Prenatal diagnosis of a bundle branch block based on the fetal ECG.

Noben L, Clur SA, van Laar JO, Vullings R.

BMJ Case Rep. 2019 Jul 1;12(7). pii: e229998. doi: 10.1136/bcr-2019-229998.

PMID: 31266761

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Select item 31392232

 

  1. Double cryoenergy application (freeze-thaw-freeze) at growing myocardium: Lesion volume and effects on coronary arteries late after energy application. Implications for efficacy and safety in pediatric patients.

Schneider HE, Stahl M, Schillinger W, Müller M, Backhoff D, Schill M, Groene N, Krause U, Sigler M, Paul T.

J Cardiovasc Electrophysiol. 2019 Jul;30(7):1127-1134. doi: 10.1111/jce.13993. Epub 2019 Jun 11.

PMID: 31111603

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  1. “A Song of Ice and Fire”-another verse from the world of ablation.

Saul JP, LaPage MJ.

J Cardiovasc Electrophysiol. 2019 Jul;30(7):1135-1137. doi: 10.1111/jce.13987. Epub 2019 Jun 11.

PMID: 31111600

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Select item 30938913

 

  1. Utility and safety of adenosine challenge for subtle ventricular pre-excitation in the pediatric population.

Follansbee CW, Beerman LB, Wu L, Bertolet M, Arora G.

J Cardiovasc Electrophysiol. 2019 Jul;30(7):1036-1041. doi: 10.1111/jce.13935. Epub 2019 Apr 22.

PMID: 30938913

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  1. What is the optimal remote monitoring schedule in pediatric patients with cardiovascular implantable electronic devices?

Tsao S.

Pacing Clin Electrophysiol. 2019 Jul;42(7):963-964. doi: 10.1111/pace.13706. Epub 2019 May 6. No abstract available.

PMID: 31034616

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ACHD Interventional Cardiology Featured Articles

CHD Interventions July 2019

 

  1. Local DRLs and automated risk estimation in paediatric interventional cardiology.

Buytaert D, Vandekerckhove K, Panzer J, Rubbens L, De Wolf D, Bacher K.

PLoS One. 2019 Jul 31;14(7):e0220359. doi: 10.1371/journal.pone.0220359. eCollection 2019.

PMID: 31365573 Free PMC Article

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  1. Infective Endocarditis in a Patient with Transcatheter Pulmonary Valve Implantation.

Wang C, Li YJ, Ma L, Pan X.

Int Heart J. 2019 Jul 27;60(4):983-985. doi: 10.1536/ihj.18-497. Epub 2019 Jun 28.

PMID: 31257331 Free Article

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  1. Transapical Mitral Melody Valve-in-Valve Implantation in a Child: An Interesting Alternative for Failing Melody Valve.

Bautista-Rodriguez C, Michielon G, Di Salvo G, Aw TC, Butera G, Kempny A, Fraisse A.

JACC Cardiovasc Interv. 2019 Jul 25. pii: S1936-8798(19)31304-4. doi: 10.1016/j.jcin.2019.06.005. [Epub ahead of print] No abstract available.

PMID: 31377271

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  1. Transvenous implantation of the Occlutech Atrial Flow Regulator: Preliminary results from swine models.

McLennan D, Ivy D, Morgan GJ.

Congenit Heart Dis. 2019 Jul 22. doi: 10.1111/chd.12816. [Epub ahead of print]

PMID: 31328339

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  1. Percutaneous Interventional Repositioning of an Inverted Left Atrial Appendage in an Infant.

Georgiev S, Ewert P.

JACC Cardiovasc Interv. 2019 Jul 22;12(14):1392-1393. doi: 10.1016/j.jcin.2019.03.021. Epub 2019 Jun 26. No abstract available.

PMID: 31255560

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  1. Hypertension in patients with repaired aortic coarctation: the long and puzzling road from Morgagni to stent implantation.

Butera G.

Heart. 2019 Jul 17. pii: heartjnl-2019-315235. doi: 10.1136/heartjnl-2019-315235. [Epub ahead of print] No abstract available.

PMID: 31315938

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  1. Retrograde transcatheter aortic valve closure in an infant with failing Norwood stage I palliation: a case report.

Fürniss HE, Kubicki R, Stiller B, Reineker K, Siepe M, Grohmann J.

J Med Case Rep. 2019 Jul 17;13(1):217. doi: 10.1186/s13256-019-2141-5.

PMID: 31311582 Free PMC Article

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  1. Titration of Bivalirudin Infusion in the Pediatric Cardiac Catheterization Laboratory: A Case Report.

Streiff A, DiNardo J, Zaleski K.

A A Pract. 2019 Jul 15;13(2):65-68. doi: 10.1213/XAA.0000000000000992.

PMID: 30907752

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  1. Early palliative balloon pulmonary valvuloplasty in neonates and young infants with tetralogy of Fallot.

Muneuchi J, Watanabe M, Sugitani Y, Kawaguchi N, Matsuoka R, Ando Y, Ochiai Y.

Heart Vessels. 2019 Jul 13. doi: 10.1007/s00380-019-01468-0. [Epub ahead of print]

PMID: 31302722

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  1. Perforation of the atretic pulmonary valve using chronic total occlusion (CTO) wire and coronary microcatheter.

Lefort B, Saint-Etienne C, Soulé N, Ma I, Dion F, Chantepie A.

Congenit Heart Dis. 2019 Jul 10. doi: 10.1111/chd.12812. [Epub ahead of print]

PMID: 31290594

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  1. Clinical outcomes after the endovascular treatments of pulmonary vein stenosis in patients with congenital heart disease.

Kurita Y, Baba K, Kondo M, Eitoku T, Kasahara S, Iwasaki T, Ohtsuki S, Tsukahara H.

Cardiol Young. 2019 Jul 9:1-9. doi: 10.1017/S1047951119001495. [Epub ahead of print]

PMID: 31287033

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  1. The effect of xenon-augmented sevoflurane-anaesthesia on intra-operative haemodynamics and postoperative neurocognitive function in children undergoing cardiac catheterization: a one-year follow up of a randomized controlled pilot trial.

Devroe S, Lemiere J, Rex S.

Paediatr Anaesth. 2019 Jul 9. doi: 10.1111/pan.13696. [Epub ahead of print]

PMID: 31287192

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Select item 31235600

 

  1. Use of the Gore Viabahn VBX balloon-expandable endoprosthesis in the congenital heart disease population.

Cole JM, Salavitabar A, Armstrong AK, Berman DP.

Catheter Cardiovasc Interv. 2019 Jul 5. doi: 10.1002/ccd.28389. [Epub ahead of print]

PMID: 31276274

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  1. Trends in surgical and catheter interventions for isolated congenital shunt lesions in the UK and Ireland.

Farooqi M, Stickley J, Dhillon R, Barron DJ, Stumper O, Jones TJ, Clift PF, Brawn WJ, Drury NE.

Heart. 2019 Jul;105(14):1103-1108. doi: 10.1136/heartjnl-2018-314428. Epub 2019 Feb 16.

PMID: 30772822 Free PMC Article

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  1. Echocardiography-Fluoroscopy Fusion Imaging for Guidance of Congenital and Structural Heart Disease Interventions.

Jone PN, Haak A, Petri N, Ross M, Morgan G, Wiktor DM, Gill E, Quaife RA, Messenger JC, Salcedo EE, Carroll JD.

JACC Cardiovasc Imaging. 2019 Jul;12(7 Pt 1):1279-1282. doi: 10.1016/j.jcmg.2018.11.010. Epub 2019 Jan 16. No abstract available.

PMID: 30660524

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  1. Aortic Valve Interventions in Pediatric Patients.

Bouhout I, Ba PS, El-Hamamsy I, Poirier N.

Semin Thorac Cardiovasc Surg. 2019 Summer;31(2):277-287. doi: 10.1053/j.semtcvs.2018.10.009. Epub 2018 Nov 2.

PMID: 30391499

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  1. Developing High Medical Technology, a Challenge for Developing Countries: The Percutaneous Closure of Atrial Septal Defects Using Nit-Occlud ASD-R: Early and Mid-term Results.

Heath A, Alvensleben IV, Navarro J, Echazú G, Kozlik-Feldmann R, Freudenthal F.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):433-439. doi: 10.1177/2150135119845257.

PMID: 31307309

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  1. Covered Stent as a Bridge to Surgery for Obstructive Melody Pulmonary Valve Endocarditis.

Sirico D, Vîjîiac A, Kempny A, Michielon G, Fraisse A.

Pediatr Cardiol. 2019 Jul 27. doi: 10.1007/s00246-019-02168-2. [Epub ahead of print]

PMID: 31352491

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  1. Gradient over Melody valve in left AV valve position reduces with beta blockade.

Krasemann T, van de Woestijne P, van den Berg G.

Cardiol Young. 2019 Jul 23:1-2. doi: 10.1017/S1047951119001616. [Epub ahead of print]

PMID: 31331407

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  1. Holographic Augmented Reality and 3D Printing for Advanced Planning of Sinus Venosus ASD/Partial Anomalous Pulmonary Venous Return Percutaneous Management.

Butera G, Sturla F, Pluchinotta FR, Caimi A, Carminati M.

JACC Cardiovasc Interv. 2019 Jul 22;12(14):1389-1391. doi: 10.1016/j.jcin.2019.03.020. Epub 2019 May 15. No abstract available.

PMID: 31103542

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Select item 31332468

 

  1. Prospective concurrent head-to head comparison of three different types of nitinol occluder device for transcatheter closure of secundum atrial septal defects.

Bhattacharjya S, Pillai LS, Doraiswamy V, Satyanarayana RM, Chandrasekaran R, Pavithran S, Sivakumar K.

EuroIntervention. 2019 Jul 20;15(4):e321-e328. doi: 10.4244/EIJ-D-18-01016.

PMID: 30946015 Free Article

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Select item 31327027

 

  1. Retrograde transcatheter aortic valve closure in an infant with failing Norwood stage I palliation: a case report.

Fürniss HE, Kubicki R, Stiller B, Reineker K, Siepe M, Grohmann J.

J Med Case Rep. 2019 Jul 17;13(1):217. doi: 10.1186/s13256-019-2141-5.

PMID: 31311582 Free PMC Article

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  1. Surgical ductal stent implantation in total anomalous pulmonary venous connection to vena porta with right pulmonary sequestration in a mature newborn.

Solgun HA, Polat TB.

Ann Med Surg (Lond). 2019 Jul 11;45:33-35. doi: 10.1016/j.amsu.2019.07.005. eCollection 2019 Sep.

PMID: 31360457 Free PMC Article

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Select item 31293050

 

 

  1. Transcatheter mitral valve-in-valve implantation in a pediatric patient.

Momenah TS, Alsahari A, Ahmed E, Al Khalaf K.

Catheter Cardiovasc Interv. 2019 Jul 11. doi: 10.1002/ccd.28390. [Epub ahead of print]

PMID: 31293050

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Select item 31291775

 

  1. Postoperative and short-term atrial tachyarrhythmia burdens after transcatheter vs surgical pulmonary valve replacement among congenital heart disease patients.

Wadia SK, Lluri G, Aboulhosn JA, Laks H, Biniwale RM, Van Arsdell GS, Levi DS, Salem MM, Shannon KM, Moore JP.

Congenit Heart Dis. 2019 Jul 7. doi: 10.1111/chd.12818. [Epub ahead of print]

PMID: 31282099

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Select item 31248305

 

  1. Elective Extracorporeal Membrane Oxygenation Support for High-Risk Pediatric Cardiac Catheterization.

Zaleski KL, Scholl RL, Thiagarajan RR, Porras D, Mah D, DiNardo JA, Nasr VG.

J Cardiothorac Vasc Anesth. 2019 Jul;33(7):1932-1938. doi: 10.1053/j.jvca.2019.01.008. Epub 2019 Jan 4.

PMID: 30902553

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Select item 31111603

 

  1. Echocardiography-Fluoroscopy Fusion Imaging for Guidance of Congenital and Structural Heart Disease Interventions.

Jone PN, Haak A, Petri N, Ross M, Morgan G, Wiktor DM, Gill E, Quaife RA, Messenger JC, Salcedo EE, Carroll JD.

JACC Cardiovasc Imaging. 2019 Jul;12(7 Pt 1):1279-1282. doi: 10.1016/j.jcmg.2018.11.010. Epub 2019 Jan 16. No abstract available.

PMID: 30660524

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Select item 31216577

 

  1. Ultrasound-Guided Femoral Arterial Cannulation in Neonates Undergoing Cardiac Surgery or Catheterization: Comparison of 0.014-Inch Floppy Versus 0.019-Inch Straight Guidewire.

Polat TB.

Pediatr Crit Care Med. 2019 Jul;20(7):608-613. doi: 10.1097/PCC.0000000000001916.

PMID: 31013264

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Select item 30925574

 

  1. Utilization of an Abiomed Impella Device as a Rescue Therapy for Acute Ventricular Failure in a Fontan Patient.

Coffman ZJ, Bandisode VM, Kavarana MN, Buckley JR.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):518-519. doi: 10.1177/2150135119847147.

PMID: 31307293

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ACHD Surgery

Congenital Heart Surgery Reviews of July 2019 Manuscripts

 

 Primary Transplantation for Congenital Heart Disease in the Neonatal Period: Long-term Outcomes.
John MM, Razzouk AJ, Chinnock RE, Bock MJ, Kuhn MA, Martens TP, Bailey LL.
Ann Thorac Surg. 2019 Jul 27. pii: S0003-4975(19)31062-8. doi: 10.1016/j.athoracsur.2019.06.022. [Epub ahead of print]
PMID: 31362016
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Select item 31257331

Take Home Points:

• Primary cardiac transplantation of neonates is an alternative treatment strategy to palliative reconstruction of uncorrectable congenital heart disease.
• This authors reviewed their single-institution experience with primary cardiac transplantation of neonates between 1985 and 2017 and found their results to be durable with acceptable long-term survival.

Commentary from Dr. Timothy Pirolli (Dallas), section editor of Congenital Heart Surgery Journal Watch: Until the early 1980s with the advent of the Norwood palliation, hypoplastic left heart syndrome was uniformly fatal. During this period, primary cardiac transplantation for neonates (and older children) was pioneered as well. As outcomes for the Norwood procedure improved in the 1990s, surgeons focused on that palliation pathway rather than primary transplant. However, there is data that shows that long-term survival for neonates undergoing primary cardiac transplant is excellent, and longer than for other age groups. This study was designed to examine the outcomes from the largest single-center series of primary neonatal heart transplants in the world at Loma Linda.

The authors reviewed their database for neonatal heart transplants between November 1985 and December 2017. They looked not only at pre- and post-operative risk factors, but also at long-term outcomes and growth/neurologic development. There was no comparison group for patients of the same age range with uncorrectable congenital heart disease who received either no surgery or palliative procedures (including the Norwood procedure). The authors described the evolution of surgical technique, immunosuppression protocols, and post-transplant surveillance.

There were 104 neonates during the study period who underwent primary cardiac transplant, of which 88 of those occurred between 1985 and 1995 (Figure 1). This was attributed to the emerging acceptance of the Norwood procedure as a primary palliative procedure for HLHS/variants after this time (as well as a sharp decline in available donors). HLHS/variants comprised 77.8% of primary diagnoses in this cohort. The diagnoses were made in utero in 35.5% of patients and 20 patients were actually listed for transplant prenatally! Median weight at transplant was 3.3 kg and median age was 17 days. An array of recipient and donor characteristics were assessed. Of note, a donor-to-recipient ratio of > 2 was found in 37.5% of transplants. Operative details revealed a 5.7% perioperative mortality of 5.7% with a median duration of follow-up of 19.9 years. Of the 104 patients, 62 are still alive at the time of the publication (Figure 2) with good 10-, 20- and 25-year survival rates.

The authors also examined the development of coronary artery vasculopathy (Figure 3) and post-transplant lymphoproliferative disease. A total of 16 patients required re-transplant (Figure 5). Of the 42 patients who died, 12 died from rejection and 6 from infection. Other notable post-operative complications are catalogued in the paper and none are unusual or occur at abnormally high frequency. The majority of surviving patients (81.2%) were of appropriate height and weight for age and almost 70% were at an appropriate education level or gainfully employed. A multivariate analysis for risk factors affecting survival showed that Glomerular Filtration Rate and the diagnosis of coronary artery vasculopathy were the main variables to have an effect on mortality.

The authors’ commentary was helpful in understanding the evolution of primary neonatal cardiac transplant at Loma Linda. Their conclusion of the therapy as durable with a minimal need for re-intervention certainly seems like a logical conclusion. So why is it not more prevalent at their institution and others? The small donor pool is part of the answer. Their discussion about the causes of and potential solutions to this issue have been discussed in prior publications, but their points resonate louder with these very good results from their transplant experience. The ideas of ABO-incompatible transplant and over-sizing donor grafts are utilized at our institution and others. The idea of utilizing donors with anencephaly was also discussed as was the associated ethical and PR-related issues surrounding it.

So these results are very good, but are they reproducible? We may never know unless there is a dramatic shift back towards utilizing cardiac transplant as a primary therapy for neonates. But who are the patients that were not offered transplant for whatever reasons? What was the waitlist mortality? Are these results as good as they are because only the “best” candidates with uncorrectable heart disease were offered transplant? It is certainly an impressive series with excellent follow-up… but the skeptic may suggest the findings, though imperfect, are almost “too good” for that first decade of neonatal transplant.

But maybe the skeptics are wrong. Maybe we over-rely on the Norwood procedure and even mechanical circulatory support to palliate patients that may be better off with a primary cardiac transplantation. One idea that was rarely utilized was listing for transplant for a fetus, which was stopped in 2016. According to a 2014 paper by Thrush and Hoffman in the Journal of Thoracic Disease, PHTS registry data indicated fetal listing in 46 of the 4,365 (1%) patients between 1993 and 2009. But what happens if expecting parents of a fetus with HLHS finds this paper from Loma Linda and compares it to published results from the Norwood palliation and request a primary transplant from their cardiologist/surgeon? These are the interesting questions that may result from this type of data.

Tables and Figures

Figure 1: Neonatal Heart Transplantation

Figure 2: Overall Survival

Figure 3: Freedom from Cardiac Allograft Vasculopathy

Figure 5: Freedom from Re-transplantation

14. Outcomes of Bioprosthetic Valves in the Pulmonary Position in Adults with Congenital Heart Disease.
Egbe AC, Connolly HM, Miranda WR, Dearani JA, Schaff HV.
Ann Thorac Surg. 2019 Jul 16. pii: S0003-4975(19)31033-1. doi: 10.1016/j.athoracsur.2019.05.068. [Epub ahead of print]
PMID: 31323213
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Select item 31313513

Take-Home Points:
• This large single-institution study with longer term follow-up evaluated the durability of bioprosthetic pulmonary valve replacement in adult patients as well as risk factors for prosthetic valve dysfunction.
• Factors associated with prosthetic valve dysfunction included prior history of atrial fibrillation and greater than moderate right ventricular dysfunction.
• The use of vitamin K antagonists at the time of hospital discharge was associated with lower risk of prosthetic valve dysfunction.

Commentary from Dr. Jeremy Herrmann (Indianapolis), section editor of Congenital Heart Surgery Journal Watch: This retrospective review adult patients who underwent surgical bioprosthetic pulmonary valve repair over an 18-year period at the Mayo Clinic evaluated at prosthetic valve dysfunction not simply as occurrences of reintervention but other hemodynamic parameters to more accurately gauge prosthetic pulmonary valve longevity. The authors defined prosthetic valve dysfunction as a peak valve velocity of >4 m/sec and/or severe pulmonary regurgitation. In all, 573 patients met inclusion criteria with a mean age 32 years at the time of valve replacement. Pericardial prostheses were most commonly used, and all valve types and parameters are listed in Table 2. Patients were followed for a mean 16.8 +/- 4.2 years.

Subsequent reintervention occurred in 201 patients (35% total; 192 surgical and 9 transcatheter valve replacement). Of these, 48 (9%) required another intervention. In all, 807 bioprosthetic pulmonary valves were implanted in 573 patients. The overall freedom from reintervention at 10 and 15 years was 83% and 61%, respectively. When looking at hemodynamic parameters, the average time-to-prosthetic valve dysfunction was 12.6 years with an incidence at 10 and 15 years of 27% and 48%, respectively. In the multivariable risk factor model, factors associated with prosthetic valve dysfunction included history of atrial fibrillation and greater than moderate right ventricular dysfunction. The use of vitamin K antagonists at the time of hospital discharge was associated with lower risk of prosthetic valve dysfunction.

This study with excellent long-term follow-up offers significant insight into the current phase of care of adult congenital heart disease patients who require ongoing right ventricular outflow tract reintervention. These data show that prosthetic valve dysfunction starts to become a significant factor 10-15 years after valve replacement. Patients with more significant right heart dysfunction may be at risk for earlier development of prosthetic valve dysfunction, though the reasons for this are not clarified in this study. Interestingly, the use of vitamin K antagonists may be helpful in improving valve durability like bioprosthetic valves inserted in left heart positions. It is unclear for how long this treatment occurred and whether patients were also treated with aspirin. Importantly, no cases of endocarditis are reported in this study.

This large series spans almost 20 years, and it is possible changes in surgical techniques and prosthetic materials may have affected prosthetic valve durability over the course of the study. Additional information about concomitant cardiac procedures at the time of pulmonary valve replacement (e.g., MAZE procedure, pulmonary arterioplasty, etc.) may be helpful for better understanding this patient group and other risks for later valve dysfunction. One significant omission may be the use of stentless porcine aortic root grafts, which is the preferred prosthesis for pulmonary valve replacement in adults at our institution. This highlights one of the major limitations of a single institution study as well as the need for more collaborative research efforts.


CHD Surgery July 2019

  1. Rare Association Between Atrioventricular Septal Defect and Partial Anomalous Pulmonary Venous Connection.

Murakami AN, Baston GG, Cardoso MRR, Marchi CH, Croti UA.

Braz J Cardiovasc Surg. 2019 Jul 31. doi: 10.21470/1678-9741-2019-0203. [Epub ahead of print]

PMID: 31364828

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  1. Vacuum-assisted closure versus closed irrigation for deep sternal wound infection treatment in infants: a propensity score-matched study.

Ivanzov S, Soynov I, Kulyabin Y, Zubritskiy A, Voitov A, Omelchenko A, Arkhipov A, Bogachev-Prokophiev A.

Interact Cardiovasc Thorac Surg. 2019 Jul 30. pii: ivz167. doi: 10.1093/icvts/ivz167. [Epub ahead of print]

PMID: 31361302

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  1. Aortic translocation procedure: Early outcomes from a single center.

Korun O, Yurdakök O, Çiçek M, Altın FH, Selçuk A, Kılıç Y, Kudsioğlu ŞT, Bulut MO, Erdem H, Aydemir NA, Şaşmazel A.

J Card Surg. 2019 Jul 29. doi: 10.1111/jocs.14188. [Epub ahead of print]

PMID: 31355951

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Select item 31384469

 

  1. Primary Transplantation for Congenital Heart Disease in the Neonatal Period: Long-term Outcomes.

John MM, Razzouk AJ, Chinnock RE, Bock MJ, Kuhn MA, Martens TP, Bailey LL.

Ann Thorac Surg. 2019 Jul 27. pii: S0003-4975(19)31062-8. doi: 10.1016/j.athoracsur.2019.06.022. [Epub ahead of print]

PMID: 31362016

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  1. Transfusion-related acute hepatic injury following postoperative platelets administration in pediatric patients undergoing the Fontan procedure.

Pollak U, Ruderman T, Borik-Chiger S, Mishaly D, Serraf A, Vardi A.

Congenit Heart Dis. 2019 Jul 25. doi: 10.1111/chd.12825. [Epub ahead of print]

PMID: 31343842

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Select item 31343841

 

  1. Surgical treatment of anomalous left main coronary artery with an intraconal course.

Mainwaring RD, Hanley FL.

Congenit Heart Dis. 2019 Jul 25. doi: 10.1111/chd.12826. [Epub ahead of print]

PMID: 31343841

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  1. Degradation and in vivo evaluation of polycaprolactone, poly(ε-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts.

Agarwal R, Blum KM, Musgrave A, Onwuka EA, Yi T, Reinhardt JW, A Best C, Breuer CK.

Regen Med. 2019 Jul 25. doi: 10.2217/rme-2018-0069. [Epub ahead of print]

PMID: 31342857

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  1. Impact of Characteristics at Stage-2-Palliation on Outcome Following Fontan Completion.

Vitanova K, Shiraishi S, Mayr B, Beran E, Cleuziou J, Strbad M, Röhlig C, Hager A, Hörer J, Lange R, Ono M.

Pediatr Cardiol. 2019 Jul 24. doi: 10.1007/s00246-019-02172-6. [Epub ahead of print]

PMID: 31342112

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  1. Management of a young patient with dextrocardia, atrial septal defect, and Eisenmenger syndrome with venous-venous extracorporeal membrane oxygenation and heart-lung transplantation.

Rajab TK, Kim T, Keller S, Mallidi H.

J Card Surg. 2019 Jul 23. doi: 10.1111/jocs.14168. [Epub ahead of print]

PMID: 31332841

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Select item 31332952

 

  1. Postoperative and long-term outcomes in children with Trisomy 21 and single ventricle palliation.

Peterson JK, Setty SP, Knight JH, Thomas AS, Moller JH, Kochilas LK.

Congenit Heart Dis. 2019 Jul 22. doi: 10.1111/chd.12823. [Epub ahead of print]

PMID: 31332952

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Select item 31328377

 

  1. Pediatric heart transplantation in the current era.

D’Addese L, Joong A, Burch M, Pahl E.

Curr Opin Pediatr. 2019 Jul 22. doi: 10.1097/MOP.0000000000000805. [Epub ahead of print]

PMID: 31335745

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Select item 31383544

 

  1. Reversible right heart failure after redo operation of a post-traumatic Gerbode defect.

Fragoulis S, Contrafouris C, Thanopoulos A, Kyriakoulis K, Apostolopoulou S.

Perfusion. 2019 Jul 21:267659119859122. doi: 10.1177/0267659119859122. [Epub ahead of print]

PMID: 31328690

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Select item 31327174

 

  1. Inadequate oxygen delivery index dose is associated with cardiac arrest risk in neonates following cardiopulmonary bypass surgery.

Futterman C, Salvin JW, McManus M, Lowry AW, Baronov D, Almodovar MC, Pineda JA, Nadkarni VM, Laussen PC, Gazit AZ.

Resuscitation. 2019 Jul 17;142:74-80. doi: 10.1016/j.resuscitation.2019.07.013. [Epub ahead of print]

PMID: 31325555

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Select item 29262000

 

  1. Outcomes of Bioprosthetic Valves in the Pulmonary Position in Adults with Congenital Heart Disease.

Egbe AC, Connolly HM, Miranda WR, Dearani JA, Schaff HV.

Ann Thorac Surg. 2019 Jul 16. pii: S0003-4975(19)31033-1. doi: 10.1016/j.athoracsur.2019.05.068. [Epub ahead of print]

PMID: 31323213

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Select item 31313513

 

  1. Impact of Durable Ventricular Assist Device Support on Outcomes of Patients with Congenital Heart Disease Waiting for Heart Transplant.

Cedars A, Tecson KM, Zaidi AN, Lorts A, McCullough PA.

ASAIO J. 2019 Jul 15. doi: 10.1097/MAT.0000000000001041. [Epub ahead of print]

PMID: 31335373

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Select item 31304897

 

  1. Right ventricular outflow tract reconstruction with the Labcor® stentless valved pulmonary conduit.

Jussli-Melchers J, Scheewe J, Hansen JH, Grothusen C, Steer J, Voges I, Logoteta J, Dütschke P, Kramer HH, Attmann T.

Eur J Cardiothorac Surg. 2019 Jul 13. pii: ezz200. doi: 10.1093/ejcts/ezz200. [Epub ahead of print]

PMID: 31302680

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Select item 31302706

 

  1. Outcome for children following admission to hospital with a first episode of heart failure, due to heart muscle disease, in the ventricular assist device (VAD) era.

Rico-Armada A, Crossland DS, Coats L, Reinhardt Z, Hermuzi A, Seller N, Hasan A, O’Sullivan JJ.

Cardiol Young. 2019 Jul 12:1-5. doi: 10.1017/S1047951119001021. [Epub ahead of print]

PMID: 31298178

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Select item 31336927

 

  1. Progenitor Cells Derived from Drain Waste Product of Open-Heart Surgery in Children.

Wong TW, Kan CD, Chiu WT, Fok KL, Ruan YC, Jiang X, Chen J, Kao CC, Chen IY, Lin HC, Chou CH, Lin CW, Yu CK, Tsao S, Lee YP, Chan HC, Wang JN.

J Clin Med. 2019 Jul 12;8(7). pii: E1028. doi: 10.3390/jcm8071028.

PMID: 31336927 Free Article

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Select item 31306764

 

  1. Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass.

Kim-Campbell N, Gretchen C, Ritov VB, Kochanek PM, Balasubramani GK, Kenny E, Sharma M, Viegas M, Callaway C, Kagan VE, Bayír H.

Pediatr Crit Care Med. 2019 Jul 11. doi: 10.1097/PCC.0000000000002036. [Epub ahead of print]

PMID: 31305328

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  1. Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry “MYKKE”.

Schubert S, Opgen-Rhein B, Boehne M, Weigelt A, Wagner R, Müller G, Rentzsch A, Zu Knyphausen E, Fischer M, Papakostas K, Wiegand G, Ruf B, Hannes T, Reineker K, Kiski D, Khalil M, Steinmetz M, Fischer G, Pickardt T, Klingel K, Messroghli DR, Degener F; MYKKE consortium.

Pediatr Transplant. 2019 Jul 11:e13548. doi: 10.1111/petr.13548. [Epub ahead of print]

PMID: 31297930

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Select item 31288878

 

  1. Risk factors for chylothorax and persistent serous effusions after congenital heart surgery.

Raatz A, Schöber M, Zant R, Cesnjevar R, Rüffer A, Purbojo A, Dittrich S, Alkassar M.

Eur J Cardiothorac Surg. 2019 Jul 10. pii: ezz203. doi: 10.1093/ejcts/ezz203. [Epub ahead of print]

PMID: 31292607

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Select item 31292191

 

  1. Congenital heart surgery Outcomes in Turner syndrome: Society of Thoracic Surgeons Database Analysis.

Chew JD, Hill KD, Jacobs ML, Jacobs JP, Killen SAS, Godown J, Wallace AS, Thibault D, Chiswell K, Bichell DP, Soslow JH.

Ann Thorac Surg. 2019 Jul 9. pii: S0003-4975(19)31000-8. doi: 10.1016/j.athoracsur.2019.05.047. [Epub ahead of print]

PMID: 31299232

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Select item 31286753

 

  1. Predictors of postoperative outcomes in infants with low birth weight undergoing congenital heart surgery: a retrospective observational study.

Lu C, Yu L, Wei J, Chen J, Zhuang J, Wang S.

Ther Clin Risk Manag. 2019 Jul 9;15:851-860. doi: 10.2147/TCRM.S206147. eCollection 2019.

PMID: 31371972 Free PMC Article

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Select item 31287062

 

  1. Emergent Decompression Of Intracranial Abscess In Eisenmenger Syndrome.

Casabella AM, Perry A, Graffeo CS, Marcellino CR, Carlstrom LP, Rabinstein AA.

World Neurosurg. 2019 Jul 8. pii: S1878-8750(19)31906-0. doi: 10.1016/j.wneu.2019.07.010. [Epub ahead of print]

PMID: 31295595

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Select item 31282099

 

  1. Prediction of complications after paediatric cardiac surgery.

Zeng X, An J, Lin R, Dong C, Zheng A, Li J, Duan H, Shu Q, Li H.

Eur J Cardiothorac Surg. 2019 Jul 6. pii: ezz198. doi: 10.1093/ejcts/ezz198. [Epub ahead of print]

PMID: 31280308

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Select item 31280306

 

  1. Elastica degeneration and intimal hyperplasia lead to Contegra® conduit failure.

Peivandi AD, Seiler M, Mueller KM, Martens S, Malec E, Asfour B, Lueck S.

Eur J Cardiothorac Surg. 2019 Jul 6. pii: ezz199. doi: 10.1093/ejcts/ezz199. [Epub ahead of print]

PMID: 31280306

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Select item 31278077

 

  1. Outcome following heart transplant assessment in adults with congenital heart disease.

Crossland DS, Jansen K, Parry G, Harper A, Perri G, Davidson A, De Rita F, Hermuzi A, Nassar M, Seller N, MacGowan GA, Hasan A, O’Sullivan JJ, Coats L.

Heart. 2019 Jul 5. pii: heartjnl-2019-314711. doi: 10.1136/heartjnl-2019-314711. [Epub ahead of print]

PMID: 31278142 Free Article

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Select item 31278424

 

  1. C1 esterase inhibitor in pediatric cardiac surgery with cardiopulmonary bypass plays a vital role in activation of the complement system.

Miyamoto T, Ozaki S, Inui A, Tanaka Y, Yamada Y, Matsumoto N.

Heart Vessels. 2019 Jul 5. doi: 10.1007/s00380-019-01466-2. [Epub ahead of print]

PMID: 31278424

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Select item 30249945

 

  1. Pulmonary versus aortic pressure behavior of a bovine pericardial valve.

Pragt H, van Melle JP, Verkerke GJ, Mariani MA, Ebels T.

J Thorac Cardiovasc Surg. 2019 Jul 5. pii: S0022-5223(19)31338-8. doi: 10.1016/j.jtcvs.2019.05.084. [Epub ahead of print]

PMID: 31383558

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Select item 31277675

 

  1. Contemporary Outcomes of the Fontan Operation: A Large Single-Institution Cohort.

Mery CM, De León LE, Trujillo-Diaz D, Ocampo EC, Dickerson HA, Zhu H, Adachi I, Heinle JS, Fraser CD Jr, Ermis PR.

Ann Thorac Surg. 2019 Jul 4. pii: S0003-4975(19)30930-0. doi: 10.1016/j.athoracsur.2019.05.039. [Epub ahead of print]

PMID: 31279788

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Select item 31273028

 

  1. Commentary: Is prosthesis oversizing warranted for pulmonary valve replacement in patients with congenital heart disease?

Bryant R 3rd.

J Thorac Cardiovasc Surg. 2019 Jul 4. pii: S0022-5223(19)31336-4. doi: 10.1016/j.jtcvs.2019.06.044. [Epub ahead of print] No abstract available.

PMID: 31350022

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Select item 31276179

 

  1. Cyanotic Congenital Cardiac Disease and Scoliosis: Pre-operative Assessment, Surgical Treatment and Outcomes.

Tsirikos AI, Augustithis G, McKean G, Karampalis C.

Med Princ Pract. 2019 Jul 3. doi: 10.1159/000501840. [Epub ahead of print]

PMID: 31266026 Free Article

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Select item 31270738

 

  1. Late correction of tetralogy of Fallot in children.

Heinisch PP, Guarino L, Hutter D, Bartkevics M, Erdoes G, Eberle B, Royo C, Rhissass J, Pfammatter JP, Carrel T, Kadner A.

Swiss Med Wkly. 2019 Jul 3;149:w20096. doi: 10.4414/smw.2019.20096. eCollection 2019 Jul 1.

PMID: 31269224 Free Article

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Select item 31270117

 

  1. Cardiac Surgery in Patients With Trisomy 13 and 18: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Cooper DS, Riggs KW, Zafar F, Jacobs JP, Hill KD, Pasquali SK, Swanson SK, Gelehrter SK, Wallace A, Jacobs ML, Morales DLS, Bryant R 3rd.

J Am Heart Assoc. 2019 Jul 2;8(13):e012349. doi: 10.1161/JAHA.119.012349. Epub 2019 Jun 25.

PMID: 31237190 Free PMC Article

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Select item 31277900

 

  1. Time for evidence-based, standardized donor size matching for pediatric heart transplantation.

Riggs KW, Giannini CM, Szugye N, Woods J, Chin C, Moore RA, Morales DLS, Zafar F.

J Thorac Cardiovasc Surg. 2019 Jul 2. pii: S0022-5223(19)31329-7. doi: 10.1016/j.jtcvs.2019.06.037. [Epub ahead of print]

PMID: 31353104

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Select item 30903232

 

  1. Measurement of Residual Collateral Flow in Pulmonary Atresia With Major Aortopulmonary Collaterals.

Mainwaring RD, Margetson TD, McCarthy P, Sleasman J, Jahadi O, Shuttleworth P, Sheff D, Kollmann S, Patrick WL, Hanley FL.

Ann Thorac Surg. 2019 Jul;108(1):154-159. doi: 10.1016/j.athoracsur.2019.02.053. Epub 2019 Mar 27.

PMID: 30928554

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Select item 31281036

 

  1. Extracorporeal cardiopulmonary resuscitation in children after open heart surgery.

Guo Z, Yang Y, Zhang W, Shen J, Jiang L, Yu X, Wang W.

Artif Organs. 2019 Jul;43(7):633-640. doi: 10.1111/aor.13408. Epub 2019 Jan 14.

PMID: 30515882

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Select item 31216182

 

  1. Histological analysis of failed submucosa patches in congenital cardiac surgery.

Heinisch PP, Banz Y, Langhammer B, Stocker E, Erdoes G, Hutter D, Carrel T, Kadner A.

Asian Cardiovasc Thorac Ann. 2019 Jul;27(6):459-463. doi: 10.1177/0218492319858557. Epub 2019 Jun 19. No abstract available.

PMID: 31216182

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Select item 30920163

 

  1. A child with a stroke, drug-refractory epilepsy and congenital heart disease: can a hemispherectomy be safely performed between staged cardiac procedures?

Jain P, Haller C, Pulcine E, Ochi A, Dipchand A, Weiss SK, Chin V, Ibrahim GM.

Childs Nerv Syst. 2019 Jul;35(7):1245-1249. doi: 10.1007/s00381-019-04171-7. Epub 2019 May 2.

PMID: 31044297

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Select item 31256636

 

  1. Living-donor lung transplantation after surgical repair of transposition of the great arteries.

Yoshinaga D, Baba S, Hirata T, Fukushima H, Hamaji M, Aoyama A, Chen-Yoshikawa TF, Yamagishi H, Date H, Heike T.

Gen Thorac Cardiovasc Surg. 2019 Jul;67(7):640-643. doi: 10.1007/s11748-018-1006-y. Epub 2018 Sep 6.

PMID: 30191531

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Select item 31329362

 

  1. Early extubation improves outcome following extracardiac total cavopulmonary connection.

Ono M, Georgiev S, Burri M, Mayr B, Cleuziou J, Strbad M, Balling G, Hager A, Hörer J, Lange R.

Interact Cardiovasc Thorac Surg. 2019 Jul 1;29(1):85-92. doi: 10.1093/icvts/ivz010.

PMID: 31220277

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Select item 30789218

 

  1. A new palliative surgical technique for high risk Total anomalous pulmonary venous connection (Sarmast-Takriti shunt).

Sarmast H, Takriti A.

J Cardiothorac Surg. 2019 Jul 1;14(1):127. doi: 10.1186/s13019-019-0953-4.

PMID: 31262322 Free PMC Article

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Select item 30686658

 

  1. Pediatric Transfusion Algorithms: Coming to a Cardiac Operating Room Near You.

Machovec KA, Jooste EH.

J Cardiothorac Vasc Anesth. 2019 Jul;33(7):2017-2029. doi: 10.1053/j.jvca.2018.12.008. Epub 2018 Dec 5. Review.

PMID: 30686658

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Select item 30642679

 

  1. Evaluation of Dynamic Ultrasound for Arterial Access in Children Undergoing Cardiac Surgery.

Staudt GE, Eagle SS, Hughes AK, Donahue BS.

J Cardiothorac Vasc Anesth. 2019 Jul;33(7):1926-1929. doi: 10.1053/j.jvca.2018.11.050. Epub 2018 Dec 1.

PMID: 30642679

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Select item 30638924

 

  1. Risk factors for death or heart transplantation in single-ventricle physiology (tricuspid atresia, pulmonary atresia, and heterotaxy): A systematic review and meta-analysis.

Kulkarni A, Patel N, Singh TP, Mossialos E, Mehra MR.

J Heart Lung Transplant. 2019 Jul;38(7):739-747. doi: 10.1016/j.healun.2019.04.001. Epub 2019 Apr 4.

PMID: 31006521

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Select item 31256695

 

  1. Comparison of postoperative chylothorax in infants and children with trisomy 21 and without dysmorphic syndrome: Is there a difference in clinical outcome?

Buchwald MA, Laasner U, Balmer C, Cannizzaro V, Latal B, Bernet V.

J Pediatr Surg. 2019 Jul;54(7):1298-1302. doi: 10.1016/j.jpedsurg.2018.06.032. Epub 2018 Jul 6.

PMID: 30057209

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Select item 31198399

 

  1. Outcome of cardiac surgery in adults with congenital heart disease: A single center experience.

Abouelella RS, Habib EA, AlHalees ZY, Alanazi MN, Ibhais ME, Alwadai AH.

J Saudi Heart Assoc. 2019 Jul;31(3):145-150. doi: 10.1016/j.jsha.2019.05.003. Epub 2019 May 18.

PMID: 31198399 Free PMC Article

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Select item 31080324

 

  1. Commentary: The intercoronary pillar-Not necessarily an innocent bystander.

Martínez-Bravo LE, Mery CM.

J Thorac Cardiovasc Surg. 2019 Jul;158(1):218-219. doi: 10.1016/j.jtcvs.2019.02.037. Epub 2019 Feb 21. No abstract available.

PMID: 30961979

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Select item 30948317

 

  1. Early prediction of critical events for infants with single-ventricle physiology in critical care using routinely collected data.

Ruiz VM, Saenz L, Lopez-Magallon A, Shields A, Ogoe HA, Suresh S, Munoz R, Tsui FR.

J Thorac Cardiovasc Surg. 2019 Jul;158(1):234-243.e3. doi: 10.1016/j.jtcvs.2019.01.130. Epub 2019 Feb 21.

PMID: 30948317

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Select item 30660524

 

  1. Risk Factors for Recurrent Acute Kidney Injury in Children Who Undergo Multiple Cardiac Surgeries: A Retrospective Analysis.

Hasson DC, Brinton JT, Cowherd E, Soranno DE, Gist KM.

Pediatr Crit Care Med. 2019 Jul;20(7):614-620. doi: 10.1097/PCC.0000000000001939.

PMID: 30925574

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Select item 30722724

 

  1. Sudden Death Due to Thoracic Aortic Dissection in Young People: A Multicenter Forensic Study.

Morentin Campillo B, Molina Aguilar P, Monzó Blasco A, Laborda Gálvez JL, Arrieta Pérez J, Sancho Jiménez J, Lamas Ruiz J, Lucena Romero J.

Rev Esp Cardiol (Engl Ed). 2019 Jul;72(7):553-561. doi: 10.1016/j.rec.2018.07.008. Epub 2018 Sep 1. English, Spanish.

PMID: 30177458

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Select item 30104167

 

  1. The World Database for Pediatric and Congenital Heart Surgery “A Call to Service for North American Congenital Heart Surgery Programs”.

St Louis JD, Timkovich N, Lenderman S, Jonas RA, Guleserian KJ, Tchervenkov CI, Jacobs JP, Austin EH, Plunkett MD, Myers JL, Hraska V, Sinha P, O’Brien JE Jr, Jacobs ML, Kirklin JK.

Semin Thorac Cardiovasc Surg. 2019 Summer;31(2):230-233. doi: 10.1053/j.semtcvs.2019.01.002. Epub 2019 Jan 5.

PMID: 30616005

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Select item 30391499

 

  1. Postoperative Serum Troponin Trends in Infants Undergoing Cardiac Surgery.

Su JA, Kumar SR, Mahmoud H, Bowdish ME, Toubat O, Wood JC, Kung GC.

Semin Thorac Cardiovasc Surg. 2019 Summer;31(2):244-251. doi: 10.1053/j.semtcvs.2018.08.010. Epub 2018 Sep 6.

PMID: 30194978

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Select item 30735591

 

  1. Double-lung versus heart-lung transplantation for precapillary pulmonary arterial hypertension: a 24-year single-center retrospective study.

Brouckaert J, Verleden SE, Verbelen T, Coosemans W, Decaluwé H, De Leyn P, Depypere L, Nafteux P, Van Veer H, Meyns B, Rega F, Van De Velde M, Poortmans G, Rex S, Neyrinck A, Van den Berghe G, Vlasselaers D, Van Cleemput J, Budts W, Vos R, Quarck R, Belge C, Delcroix M, Verleden GM, Van Raemdonck D.

Transpl Int. 2019 Jul;32(7):717-729. doi: 10.1111/tri.13409. Epub 2019 Mar 5.

PMID: 30735591

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Select item 30706331

 

  1. Heart Transplantation in a Fontan Patient Using a Hepatitis C-Positive Donor.

Menachem JN, Bichell DP, Frischhertz B, Shah AS, Schlendorf K.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):504. doi: 10.1177/2150135119852037.

PMID: 31307313

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  1. Right Ventricular Dominance Is Associated With Inferior Outcomes After the Extracardiac Fontan.

West C, Maul T, Feingold B, Morell VO.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):416-423. doi: 10.1177/2150135119843887.

PMID: 31307314

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Select item 31307313

 

  1. Ten Years of Data Verification: The Society of Thoracic Surgeons Congenital Heart Surgery Database Audits.

Overman DM, Jacobs ML, O’Brien JE Jr, Kumar SR, Mayer JE Jr, Ebel A, Clarke DR, Jacobs JP.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):454-463. doi: 10.1177/2150135119845256.

PMID: 31307308

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Select item 31307305

 

  1. The Association Between Cardiac Biomarker NT-proBNP and 30-Day Readmission or Mortality After Pediatric Congenital Heart Surgery.

Parker DM, Everett AD, Stabler ME, Leyenaar J, Vricella L, Jacobs JP, Thiessen-Philbrook H, Parikh C, Greenberg J, Brown JR.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):446-453. doi: 10.1177/2150135119842864.

PMID: 31307305

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Select item 31307302

 

  1. Proceedings From the 3rd Symposium of the World Database for Pediatric and Congenital Heart Surgery.

St Louis JD, Tchervenkov CI, Jonas RA, Sandoval N, Zhang H, Jacobs JP, Talwar S, Halees ZA, Finucane K, Kirklin JK.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):492-498. doi: 10.1177/2150135119852320.

PMID: 31307301

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Select item 31307298

 

  1. Right Ventricular Morphology Is Associated With Mortality at All Stages of Single Ventricle Palliation.

Iyengar AJ.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):424-425. doi: 10.1177/2150135119860382. No abstract available.

PMID: 31307298

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Select item 31307296

 

 

  1. Staged Biventricular Repair After Hybrid Procedure in High-Risk Neonates and Infants.

Erek E, Suzan D, Aydin S, Temur B, Demir IH, Odemis E.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):426-432. doi: 10.1177/2150135119845245.

PMID: 31307296

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Select item 31307294

 

  1. Met-Hemoglobin Is a Biomarker for Poor Oxygen Delivery in Infants Following Surgical Palliation.

Swartz MF, Makhija P, Rubenstein J, Henrichs KF, Powers KS, Wang HY, Simon BV, Alfieris GM, Blumberg N, Cholette JM.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):485-491. doi: 10.1177/2150135119852327. Epub 2019 May 29.

PMID: 31142197

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  1. Pediatric heart transplantation in the current era.

D’Addese L, Joong A, Burch M, Pahl E.

Curr Opin Pediatr. 2019 Jul 22. doi: 10.1097/MOP.0000000000000805. [Epub ahead of print]

PMID: 31335745

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Select item 31343584

 

  1. Palliative care in pediatric heart failure and transplantation.

Kaufman BD, Cohen HJ.

Curr Opin Pediatr. 2019 Jul 17. doi: 10.1097/MOP.0000000000000799. [Epub ahead of print]

PMID: 31335747

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Select item 31326238

 

  1. Inadequate oxygen delivery index dose is associated with cardiac arrest risk in neonates following cardiopulmonary bypass surgery.

Futterman C, Salvin JW, McManus M, Lowry AW, Baronov D, Almodovar MC, Pineda JA, Nadkarni VM, Laussen PC, Gazit AZ.

Resuscitation. 2019 Jul 17;142:74-80. doi: 10.1016/j.resuscitation.2019.07.013. [Epub ahead of print]

PMID: 31325555

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Select item 31371063

 

  1. Novel Biomarkers Improves Prediction of 365-day Readmission after Pediatric Congenital Heart Surgery.

Parker DM, Everett AD, Stabler ME, Vricella L, Jacobs ML, Jacobs JP, Parikh CR, Pasquali SK, Brown JR.

Ann Thorac Surg. 2019 Jul 16. pii: S0003-4975(19)31035-5. doi: 10.1016/j.athoracsur.2019.05.070. [Epub ahead of print]

PMID: 31323208

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Select item 31309848

 

  1. Heparin-induced thrombocytopenia complicating extracorporeal membrane oxygenation support: Review of the literature and alternative anticoagulants.

Pollak U.

J Thromb Haemost. 2019 Jul 16. doi: 10.1111/jth.14575. [Epub ahead of print] Review.

PMID: 31313454

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Select item 31310588

 

  1. Biomarkers improve prediction of 30-day unplanned readmission or mortality after paediatric congenital heart surgery.

Brown JR, Stabler ME, Parker DM, Vricella L, Pasquali S, Leyenaar JK, Bohm AR, MacKenzie T, Parikh C, Jacobs ML, Jacobs JP, Everett AD.

Cardiol Young. 2019 Jul 10:1-6. doi: 10.1017/S1047951119001471. [Epub ahead of print]

PMID: 31290383

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Select item 31288876

 

  1. Risk factors for chylothorax and persistent serous effusions after congenital heart surgery.

Raatz A, Schöber M, Zant R, Cesnjevar R, Rüffer A, Purbojo A, Dittrich S, Alkassar M.

Eur J Cardiothorac Surg. 2019 Jul 10. pii: ezz203. doi: 10.1093/ejcts/ezz203. [Epub ahead of print]

PMID: 31292607

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Select item 31292191

 

  1. True aneurysmal dilatation of a valved bovine jugular vein conduit after right ventricular outflow tract reconstruction: a rare complication.

Yoldaş T, Örün UA, Tak S.

Cardiol Young. 2019 Jul 8:1-2. doi: 10.1017/S1047951119001422. [Epub ahead of print]

PMID: 31280726

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Select item 31285546

 

  1. Heart Transplantation from Biventricular Support in Infant with Novel SMYD1 Mutation.

Coyan GN, Zinn MD, West SC, Sharma MS.

Pediatr Cardiol. 2019 Jul 5. doi: 10.1007/s00246-019-02139-7. [Epub ahead of print]

PMID: 31278431

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Select item 31387844

 

  1. Bleeding and Thrombosis With Pediatric Extracorporeal Life Support: A Roadmap for Management, Research, and the Future From the Pediatric Cardiac Intensive Care Society (Part 1).

Penk JS, Reddy S, Polito A, Cisco MJ, Allan CK, Bembea MM, Giglia TM, Cheng HH, Thiagarajan RR, Dalton HJ.

Pediatr Crit Care Med. 2019 Jul 3. doi: 10.1097/PCC.0000000000002054. [Epub ahead of print]

PMID: 31274779

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Select item 31274775

 

  1. The Effect of Levosimendan Versus Milrinone on the Occurrence Rate of Acute Kidney Injury Following Congenital Heart Surgery in Infants: A Randomized Clinical Trial.

Thorlacius EM, Suominen PK, Wåhlander H, Keski-Nisula J, Vistnes M, Ricksten SE, Synnergren M, Romlin BS, Castellheim A.

Pediatr Crit Care Med. 2019 Jul 3. doi: 10.1097/PCC.0000000000002017. [Epub ahead of print]

PMID: 31274775

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Select item 31270969

 

  1. Outcomes of Pulmonary Artery Reconstruction in Williams Syndrome.

Collins RT 2nd, Mainwaring RD, MacMillen KL, Hanley FL.

Ann Thorac Surg. 2019 Jul;108(1):146-153. doi: 10.1016/j.athoracsur.2019.02.013. Epub 2019 Mar 15.

PMID: 30885853

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Select item 30885849

 

  1. Repair of Total Anomalous Pulmonary Venous Connection: Risk Factors for Postoperative Obstruction.

White BR, Ho DY, Faerber JA, Katcoff H, Glatz AC, Mascio CE, Stephens P Jr, Cohen MS.

Ann Thorac Surg. 2019 Jul;108(1):122-129. doi: 10.1016/j.athoracsur.2019.02.017. Epub 2019 Mar 16.

PMID: 30885849

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Select item 31281036

 

  1. Use of Hemodynamic Ramp Study to Optimize Continuous-Flow Ventricular Assist Device in a Fontan Patient.

Chau P, Lim HM, Schumacher KR, Grifka RG, Peng DM.

ASAIO J. 2019 Jul;65(5):e47-e49. doi: 10.1097/MAT.0000000000000920.

PMID: 30507847

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Select item 31277759

 

  1. Point-of-care hemostasis in children with congenital heart disease, the POCHEMO study: baseline reference values of thromboelastometry and impedance aggregometry.

Longchamp D, Perez MH, Natterer J, Amiet V, Ferry T, Boegli Y, Mauron S, Dolci M, Plaza Wuthrich S, Di Bernardo S.

Blood Coagul Fibrinolysis. 2019 Jul;30(5):199-204. doi: 10.1097/MBC.0000000000000818.

PMID: 31157681

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Select item 31266761

 

  1. Tetralogy of Fallot and abnormal coronary artery: use of a prosthetic conduit is outdated.

Pontailler M, Bernard C, Gaudin R, Moreau de Bellaing A, Mostefa Kara M, Haydar A, Barbanti C, Bonnet D, Vouhé P, Raisky O.

Eur J Cardiothorac Surg. 2019 Jul 1;56(1):94-100. doi: 10.1093/ejcts/ezz030.

PMID: 30753614

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Select item 30753393

 

  1. Biventricular repair after the hybrid Norwood procedure.

Sojak V, Bokenkamp R, Kuipers I, Schneider A, Hazekamp M.

Eur J Cardiothorac Surg. 2019 Jul 1;56(1):110-116. doi: 10.1093/ejcts/ezz028.

PMID: 30753393

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Select item 30820038

 

  1. The miniaturized pediatric continuous-flow device: A successful bridge to heart transplant.

Adachi I, Spinner JA, Tunuguntla HP, Elias BA, Heinle JS.

J Heart Lung Transplant. 2019 Jul;38(7):789-793. doi: 10.1016/j.healun.2019.04.004. Epub 2019 Apr 29. No abstract available.

PMID: 31109819

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Select item 31031017

 

 

  1. Early treatment of intrapericardial teratoma: a case presentation and systematic literature review.

Cavalcante CTMB, Pinto Júnior VC, Pompeu RG, Férrer JVCC, Cavalcante MB, Araujo Júnior E, Peixoto AB, Castello Branco KM.

J Matern Fetal Neonatal Med. 2019 Jul;32(13):2262-2268. doi: 10.1080/14767058.2018.1427059. Epub 2018 Jan 22.

PMID: 29320914

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Select item 30790093

 

  1. Life-saving vascular access after combined liver and kidney transplantation: A challenging access to the right atrium.

Grimaldi C, Crocoli A, Angelico R, Saffioti MC, Nappo SG, Chiusolo F, Tortora F, Picardo SG, Dello Strologo L, Basso MS, Monti L, Guccione P, Rollo M, Spada M.

J Vasc Access. 2019 Jul;20(4):442-445. doi: 10.1177/1129729818820516. Epub 2019 Jan 4.

PMID: 30608014

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Select item 30660524

 

  1. Mobile extracorporeal membrane oxygenation for children: single-center 10 years’ experience.

Fouilloux V, Gran C, Ghez O, Chenu C, El Louali F, Kreitmann B, Le Bel S.

Perfusion. 2019 Jul;34(5):384-391. doi: 10.1177/0267659118824006. Epub 2019 Jan 12.

PMID: 30638136

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Select item 30562156

 

  1. Pulmonary Vein Stenosis: Outcomes in Children With Congenital Heart Disease and Prematurity.

DiLorenzo MP, Santo A, Rome JJ, Zhang H, Faerber JA, Mercer-Rosa L, Hopper RK.

Semin Thorac Cardiovasc Surg. 2019 Summer;31(2):266-273. doi: 10.1053/j.semtcvs.2018.09.027. Epub 2018 Sep 29.

PMID: 30278272

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Select item 30278268

 

  1. Postoperative Serum Troponin Trends in Infants Undergoing Cardiac Surgery.

Su JA, Kumar SR, Mahmoud H, Bowdish ME, Toubat O, Wood JC, Kung GC.

Semin Thorac Cardiovasc Surg. 2019 Summer;31(2):244-251. doi: 10.1053/j.semtcvs.2018.08.010. Epub 2018 Sep 6.

PMID: 30194978

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Select item 30898051

 

 

  1. Proximal Arch in Left Thoracotomy Repair of Neonatal and Infant Coarctation-How Small Is Too Small?

Callahan CP, Saudek D, Creighton S, Kuhn EM, Mitchell ME, Tweddell JS, Woods RK.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):469-474. doi: 10.1177/2150135119852329.

PMID: 31307310

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Select item 31307309

 

  1. The Association Between Cardiac Biomarker NT-proBNP and 30-Day Readmission or Mortality After Pediatric Congenital Heart Surgery.

Parker DM, Everett AD, Stabler ME, Leyenaar J, Vricella L, Jacobs JP, Thiessen-Philbrook H, Parikh C, Greenberg J, Brown JR.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):446-453. doi: 10.1177/2150135119842864.

PMID: 31307305

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Select item 31307302

 

  1. Staged Biventricular Repair After Hybrid Procedure in High-Risk Neonates and Infants.

Erek E, Suzan D, Aydin S, Temur B, Demir IH, Odemis E.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):426-432. doi: 10.1177/2150135119845245.

PMID: 31307296

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Select item 31307295

 

  1. Intramural Aortic Course Should Always Be Considered for Anomalous Origin of the Left Coronary Artery From the Right Pulmonary Artery.

Agrawal V, Vaidhya N, Patel M, Mishra A, Patel D.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):508-512. doi: 10.1177/2150135118799645. Epub 2019 Mar 27.

PMID: 30917740

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Fetal Cardiology Featured Articles

Fetal Cardiology Reviews of July 2019 Manuscripts

Transposition of the great arteries: Fetal pulmonary valve growth and postoperative neo-aortic root dilatation. van der Palen RLF, van der Zee C, Vink AS, Knobbe I, Jurgens SJ, van Leeuwen E, Bax CJ, du Marchie Sarvaas GJ, Blom NA, Haak MC, Bilardo CM, Clur SB.
Prenat Diagn. 2019 Jul 27. doi: 10.1002/pd.5539. [Epub ahead of print]

Take Home Points:

• Neoaortic root dilation is common and occasionally needs intervention in patients born with transposition of great arteries (TGA) who underwent an arterial switch operation.
• In this longitudinal study of semilunar valve size in fetal TGA subjects, semilunar valve diameters are larger than in the normal fetus, especially in those with TGA and VSD.
• Prenatal pulmonary valve size at 26 to 30 weeks determines neoaortic root size after arterial switch procedure in patients with TGA.

Commentary from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch: This is a retrospective multicenter observational study of 137 fetuses with TGA; 36% with ventricular septal defects. Arterial switch operation was performed in 121 subjects. Fetal semilunar valve diameters were significantly larger than control aortic valve diameters, especially in patients with VSD. There was positive correlation between Z‐scores of fetal TGA pulmonary valve at 26 to 30 weeks and neoaortic valve diameter at last follow‐up (P < .001).

Fetal Cardiology July 2019

 

  1. Single-Cell RNA-Seq of the Developing Cardiac Outflow Tract Reveals Convergent Development of the Vascular Smooth Muscle Cells.

Liu X, Chen W, Li W, Li Y, Priest JR, Zhou B, Wang J, Zhou Z.

Cell Rep. 2019 Jul 30;28(5):1346-1361.e4. doi: 10.1016/j.celrep.2019.06.092.

PMID: 31365875 Free Article

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Select item 31361081

 

  1. Postnatal Outcome Following Prenatal Diagnosis of Discordant Atrioventricular and Ventriculoarterial Connections.

Day TG, Woodgate T, Knee O, Zidere V, Vigneswaran T, Charakida M, Miller O, Sharland G, Simpson J.

Pediatr Cardiol. 2019 Jul 25. doi: 10.1007/s00246-019-02176-2. [Epub ahead of print]

PMID: 31342118

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Select item 31342117

 

  1. Prenatal Diagnosis of the Fetal Retroesophageal Left Brachiocephalic Vein: Case Series and Review of the Literature.

Han J, Sun L, Gu X, Zhang Y, Guo Y, Hao X, Zhao Y, He Y.

J Ultrasound Med. 2019 Jul 24. doi: 10.1002/jum.15099. [Epub ahead of print]

PMID: 31339575

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Select item 31342112

 

  1. Fetal diagnosis of Mowat-Wilson syndrome by whole exome sequencing.

Evans CA, Pinner J, Chan CY, Bowyer L, Mowat D, Buckley MF, Roscioli T.

Am J Med Genet A. 2019 Jul 19. doi: 10.1002/ajmg.a.61295. [Epub ahead of print]

PMID: 31321886

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Select item 31325067

 

  1. Three-dimensional printed multicolor normal and abnormal fetal hearts based on ultrasound imaging data.

Guo YT, Hou N, Liang JH, Zhang ZK, Cao TS, Yuan LJ.

Ultrasound Obstet Gynecol. 2019 Jul 10. doi: 10.1002/uog.20392. [Epub ahead of print] No abstract available.

PMID: 31290180

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Select item 31302917

 

  1. Fetal Complex Congenital Heart Disease Diagnosed by Prenatal Ultrasound and Corrosion Casting for Large-Vessels: A Report for Authentic Teaching by True Representation

An P, Wang Y, Xing LM, Feng W.

Balkan Med J. 2019 Jul 9. doi: 10.4274/balkanmedj.galenos.2019.2019.6.13. [Epub ahead of print] No abstract available.

PMID: 31286753 Free Article

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  1. HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.

Firulli BA, George R, Harkin J, Toolan KP, Gao H, Liu Y, Zhang W, Field LJ, Liu Y, Shou W, Payne RM, Rubart-von der Lohe M, Firulli AB.

Cardiovasc Res. 2019 Jul 9. pii: cvz182. doi: 10.1093/cvr/cvz182. [Epub ahead of print]

PMID: 31286141

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Select item 31326119

 

  1. Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility.

Robson A, Makova SZ, Barish S, Zaidi S, Mehta S, Drozd J, Jin SC, Gelb BD, Seidman CE, Chung WK, Lifton RP, Khokha MK, Brueckner M.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14049-14054. doi: 10.1073/pnas.1808341116. Epub 2019 Jun 24.

PMID: 31235600

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Select item 31371972

 

  1. The outcome of structural heart defects diagnosed in the first trimester of pregnancy.

Duta S, Veduta A, Vayna AM, Panaitescu A, Nedelea F, Peltecu G.

J Matern Fetal Neonatal Med. 2019 Jul 7:1-6. doi: 10.1080/14767058.2019.1637849. [Epub ahead of print]

PMID: 31282223

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Select item 31280308

 

  1. Amiodarone – induced thyroid dysfunction in the developmental period: prenatally, in childhood, and adolescence.

Wędrychowicz A, Furtak A, Kalicka-Kasperczyk A, Januś D, Wójcik M, Kordon Z, Rudziński A, Starzyk JB.

Endokrynol Pol. 2019 Jul 5. doi: 10.5603/EP.a2019.0030. [Epub ahead of print]

PMID: 31274186 Free Article

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Select item 31280290

 

  1. Prenatal diagnosis and prevalence of critical congenital heart defects: an international retrospective cohort study.

Bakker MK, Bergman JEH, Krikov S, Amar E, Cocchi G, Cragan J, de Walle HEK, Gatt M, Groisman B, Liu S, Nembhard WN, Pierini A, Rissmann A, Chidambarathanu S, Sipek A Jr, Szabova E, Tagliabue G, Tucker D, Mastroiacovo P, Botto LD.

BMJ Open. 2019 Jul 2;9(7):e028139. doi: 10.1136/bmjopen-2018-028139.

PMID: 31270117 Free PMC Article

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Select item 31237190

 

  1. Maternal and cord blood homocysteine, vitamin B12, folate, and B-type natriuretic peptide levels at term for predicting congenital heart disease of the neonate: A case-control study.

Sahin-Uysal N, Gulumser C, Kocaman E, Varan B, Bayraktar N, Yanık F.

J Matern Fetal Neonatal Med. 2019 Jul 1:1-8. doi: 10.1080/14767058.2019.1633300. [Epub ahead of print]

PMID: 31256695

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  1. The first Fetal Echocardiography experience for Prenatal diagnosis of Congenital Heart Disease in Lebanon: Successes and challenges.

Charafeddine F, Hachem A, Kibbi N, Abutaqa M, Bitar F, Bulbul Z, El-Rassi I, Arabi M.

J Saudi Heart Assoc. 2019 Jul;31(3):125-129. doi: 10.1016/j.jsha.2019.04.001. Epub 2019 Apr 11.

PMID: 31080324 Free PMC Article

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Select item 30961979

 

  1. Fetal carotid-jugular fistula: A case report.

Hu J, Zeng X, Yuan X.

Medicine (Baltimore). 2019 Jul;98(28):e16250. doi: 10.1097/MD.0000000000016250.

PMID: 31305405 Free Article

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Select item 31367440

 

  1. Benefits of fetal echocardiographic surveillance in pregnancies at risk of congenital heart block: single-center study of 212 anti-Ro52-positive pregnancies.

Sonesson SE, Ambrosi A, Wahren-Herlenius M.

Ultrasound Obstet Gynecol. 2019 Jul;54(1):87-95. doi: 10.1002/uog.20214. Epub 2019 Jun 7.

PMID: 30620419

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Select item 30125417

 

  1. Prenatal echocardiographic assessment of right aortic arch.

Campanale CM, Pasquini L, Santangelo TP, Iorio FS, Bagolan P, Sanders SP, Toscano A.

Ultrasound Obstet Gynecol. 2019 Jul;54(1):96-102. doi: 10.1002/uog.20098. Epub 2019 Jun 10.

PMID: 30125417

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Select item 29877000

 

  1. Fetal cardiac tumor: echocardiography, clinical outcome and genetic analysis in 53 cases.

Chen J, Wang J, Sun H, Gu X, Hao X, Fu Y, Zhang Y, Liu X, Zhang H, Han L, He Y.

Ultrasound Obstet Gynecol. 2019 Jul;54(1):103-109. doi: 10.1002/uog.19108. Epub 2019 Jun 12.

PMID: 29877000

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Select item 31307314

 

  1. Transposition of the great arteries: Fetal pulmonary valve growth and postoperative neo-aortic root dilatation.

van der Palen RLF, van der Zee C, Vink AS, Knobbe I, Jurgens SJ, van Leeuwen E, Bax CJ, du Marchie Sarvaas GJ, Blom NA, Haak MC, Bilardo CM, Clur SB.

Prenat Diagn. 2019 Jul 27. doi: 10.1002/pd.5539. [Epub ahead of print]

PMID: 31351016

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Select item 31350605

 

  1. Postnatal Cardiac Development and Regenerative Potential in Large Mammals.

Velayutham N, Agnew EJ, Yutzey KE.

Pediatr Cardiol. 2019 Jul 25. doi: 10.1007/s00246-019-02163-7. [Epub ahead of print]

PMID: 31346664

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Select item 31346663

 

  1. TwinLIFE: The Twin Longitudinal Investigation of FEtal Discordance.

Groene SG, Todtenhaupt P, van Zwet EW, van Pel M, Berkhout RJM, Haak MC, Roest AAW, Lopriore E, van Klink JMM, Heijmans BT.

Twin Res Hum Genet. 2019 Jul 25:1-6. doi: 10.1017/thg.2019.38. [Epub ahead of print]

PMID: 31342890

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Select item 31396494

 

  1. Phases and Mechanisms of Embryonic Cardiomyocyte Proliferation and Ventricular Wall Morphogenesis.

Barak Y, Hemberger M, Sucov HM.

Pediatr Cardiol. 2019 Jul 24. doi: 10.1007/s00246-019-02164-6. [Epub ahead of print]

PMID: 31342113

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Select item 31342112

 

  1. Assessment of the Fetal Myocardial Performance Index in Well-Controlled Gestational Diabetics and to Determine Whether It Is Predictive of Adverse Perinatal Outcome.

Bhorat I, Pillay M, Reddy T.

Pediatr Cardiol. 2019 Jul 19. doi: 10.1007/s00246-019-02158-4. [Epub ahead of print]

PMID: 31324952

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Select item 31321831

 

  1. Gene-based genome-wide association studies and meta-analyses of conotruncal heart defects.

Sewda A, Agopian AJ, Goldmuntz E, Hakonarson H, Morrow BE, Taylor D, Mitchell LE; Pediatric Cardiac Genomics Consortium.

PLoS One. 2019 Jul 17;14(7):e0219926. doi: 10.1371/journal.pone.0219926. eCollection 2019.

PMID: 31314787 Free PMC Article

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Select item 31325555

 

  1. A Novel 3q29 Deletion in Association With Developmental Delay and Heart Malformation-Case Report With Literature Review.

Chirita Emandi A, Dobrescu AI, Doros G, Hyon C, Miclea D, Popoiu C, Puiu M, Arghirescu S.

Front Pediatr. 2019 Jul 8;7:270. doi: 10.3389/fped.2019.00270. eCollection 2019.

PMID: 31338352 Free PMC Article

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Select item 31283021

 

  1. The non-genetic paternal factors for congenital heart defects: A systematic review and meta-analysis.

Peng J, Meng Z, Zhou S, Zhou Y, Wu Y, Wang Q, Wang J, Sun K.

Clin Cardiol. 2019 Jul;42(7):684-691. doi: 10.1002/clc.23194. Epub 2019 May 29.

PMID: 31073996 Free Article

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Select item 30785656

 

  1. Fetal iGRASP cine CMR assisting in prenatal diagnosis of complicated cardiac malformation with impact on delivery planning.

Bhat M, Haris K, Bidhult S, Liuba P, Aletras AH, Hedström E.

Clin Physiol Funct Imaging. 2019 Jul;39(4):231-235. doi: 10.1111/cpf.12566. Epub 2019 Mar 8.

PMID: 30785656

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Select item 30618044

 

  1. Maternal and cord blood homocysteine, vitamin B12, folate, and B-type natriuretic peptide levels at term for predicting congenital heart disease of the neonate: A case-control study.

Sahin-Uysal N, Gulumser C, Kocaman E, Varan B, Bayraktar N, Yanık F.

J Matern Fetal Neonatal Med. 2019 Jul 1:1-8. doi: 10.1080/14767058.2019.1633300. [Epub ahead of print]

PMID: 31256695

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Select item 29911451

 

  1. Prenatal diagnosis of aortopulmonary window by foetal echocardiography: ‘U or reversed U sign’.

Kaya B, Ekiz A, Acar DK, Sezer S, Bornaun H, Yildirim G, Aslan H.

J Obstet Gynaecol. 2019 Jul;39(5):712-713. doi: 10.1080/01443615.2018.1534817. Epub 2019 Mar 11. No abstract available.

PMID: 30856023

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Select item 30977251

 

  1. Fetal descending aortic tortuosity with ductal aneurysm.

Karmegaraj B, Rajeshkannan R, Kappanayil M, Vaidyanathan B.

Ultrasound Obstet Gynecol. 2019 Jul;54(1):142-144. doi: 10.1002/uog.20303. Epub 2019 Jun 3. No abstract available.

PMID: 31021025

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Select item 30156342

 

  1. Prenatal echocardiographic assessment of right aortic arch.

Campanale CM, Pasquini L, Santangelo TP, Iorio FS, Bagolan P, Sanders SP, Toscano A.

Ultrasound Obstet Gynecol. 2019 Jul;54(1):96-102. doi: 10.1002/uog.20098. Epub 2019 Jun 10.

PMID: 30125417

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Select item 31307310

Congenital Cardiovascular Anesthesia and Critical Care Featured Articles

CHD anesthesia and intensive care July 2019

 

  1. [Relevant aspects of the ESC guidelines for the management of cardiovascular diseases during pregnancy for obstetric anaesthesia (update 2018)].

Brück S, Seeland U, Kranke E, Kranke P.

Anaesthesist. 2019 Jul;68(7):461-475. doi: 10.1007/s00101-019-0613-z. Review. German.

PMID: 31267159

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Select item 30928554

 

  1. Fellowship Training in Pediatric Cardiac Anesthesia: History, Maturation, and Current Status.

Nasr VG, Guzzetta NA, Mossad EB.

J Cardiothorac Vasc Anesth. 2019 Jul;33(7):1828-1834. doi: 10.1053/j.jvca.2018.08.016. Epub 2018 Aug 11. Review.

PMID: 30243872

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Select item 30485421

 

  1. Early extubation improves outcome following extracardiac total cavopulmonary connection.

Ono M, Georgiev S, Burri M, Mayr B, Cleuziou J, Strbad M, Balling G, Hager A, Hörer J, Lange R.

Interact Cardiovasc Thorac Surg. 2019 Jul 1;29(1):85-92. doi: 10.1093/icvts/ivz010.

PMID: 31220277

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Select item 30698779

 

The CHIP Network Journal Watch Team

Konstantin Averin, MD, MS is an Associate Professor of Pediatrics at the University of Alberta and an Interventional Pediatric Cardiologist at the Stollery Children’s Hospital in Edmonton, Alberta. He received his medical degree from the Feinberg School of Medicine at Northwestern University in Chicago, IL. After medical school, he completed pediatrics residency, pediatric cardiology fellowship and sub-specialty training in pediatric and adult interventional cardiology at the Cincinnati Children’s Hospital in Cincinnati, OH. His clinical and research interests are focused on the percutaneous treatment of pediatric patients with congenital and acquired heart disease with a focus on patients with single ventricle physiology, transcatheter pulmonary valves, and pulmonary hypertension.

Dr. Leong Ming Chern “MC” is an adult congenital heart disease specialist at the National Heart Institute, Kuala Lumpur, Malaysia. He received his medical training at the University of Malaya and pediatric cardiology training at the National Heart Institute. His area of interest includes treatment of adult patients with congenital heart disease and pulmonary hypertension in congenital heart disease.

Dr. Damien Cullington, MBChB MRCP MD FESC is a consultant adult congenital cardiologist who works at Leeds General Infirmary, UK. In summer 2019, he will move over to the newly commissioned North West ACHD Service based in Liverpool, UK. Damien qualified in 2002 from the University of Liverpool and became a substantive consultant in 2016. Prior to this, he worked throughout the North of England and Yorkshire as a cardiology trainee. Damien was awarded a doctorate in medicine (MD) from the University of Hull in 2013 for his work in heart rate in patients with heart failure. He is a member of the Royal College of Physicians (London), Fellow of the European Society of Cardiology and honorary senior lecturer for the University of Leeds. His ACHD subspecialty clinical interests are heart failure, imaging and palliative care. He is regional organiser for ACHD training at Leeds and clinical governance lead for the Leeds congenital cardiac unit. His research interests and wide and far but particularly epidemiology, chronic heart failure in ACHD patients in all its guises, the systemic RV and the univentricle

Dr. Blanche Cupido is a consultant adult cardiologist working at Groote Schuur Hospital, UCT Private Academic Hospital and the University of Cape Town(UCT), South Africa. She completed her physician training in 2009 and her cardiology subspecialist training in 2013. She recently returned to SA after doing a Fellowship in Adult Congenital Heart Disease in Leeds, United Kingdom under the guidance of Dr Kate English. She has established a dedicated unit for Grown Up Congenital Heart Disease in Cape Town, South Africa. Her aim is to grow ACHD services in Sub-Saharan Africa and embark on GUCH research on the African continent.

Dr. Jeremy L. Herrmann is an Assistant Professor of Surgery in the Division of Thoracic and Cardiovascular Surgery at Indiana University. He specializes in pediatric and adult congenital cardiac surgery, and his clinical interests also include heart transplantation and mechanical circulatory support. His hospital affiliations include Indiana University Health Riley Hospital for Children and Methodist Hospital as well as Peyton Manning Children’s Hospital at St. Vincent Hospital in Indianapolis

Maan Jokhadar is a cardiologist and associate professor of medicine at Emory University in Atlanta, Georgia. He is board certified in internal medicine, cardiovascular disease, advanced heart failure/transplantation, adult congenital heart disease, and echocardiography. He is fellowship director for the Emory Adult Congenital Heart Disease training program and Core Curriculum Director for the Emory general cardiology fellowship program. Dr Jokhadar graduated from the University Damascus School of Medicine in Syria and then went to Mayo Clinic in Rochester, Minnesota for internal medicine residency. He then completed cardiology and subspecialty training at Emory University, where he currently on faculty. Dr. Jokhadar has been the recipient of numerous teaching awards. He is married with 3 children.

Michael Ma, MD is an Assistant Professor in Cardiothoracic Surgery in the Division of Pediatric Cardiac Surgery at Stanford University. He specializes in pediatric and adult congenital cardiac surgery, with an emphasis on neonates, complex biventricular repair, and pulmonary artery reconstruction. His research lab investigates ex and in vivo translational models for complex congenital heart disease, to optimize future surgical and endovascular repair strategies.

Jeremy P. Moore MD MS FHRS is the Director of Clinical Research and faculty in Pediatric Cardiology and Adult Congenital Heart Disease at the University of California, Los Angeles. Dr. Moore received his medical degree from the Medical College of Virginia in 2003. He completed residency and fellowship at UCLA before pursuing his subspecialty training in Pediatric Electrophysiology at Vanderbilt University in 2009. Dr. Moore has been faculty at UCLA since 2010 and has since published numerous research manuscripts dealing with electrophysiologic aspects pertinent to congenital heart disease. Dr. Moore’s primary interest is the study of mechanisms of arrhythmia, and the development of novel electrophysiologic techniques for management of the adult patient with congenital heart disease

Dr. Mehul Patel MD, is a structural and adult congenital heart disease specialist and an interventional cardiologist. Dr. Patel earned his undergraduate and medical education from the Mumbai University, India. After completing his post-graduate training in Internal Medicine and Cardiology, he further trained in interventional cardiology at the Mount Sinai Medical Center, NYC, NY and Adult Congenital Heart Disease at the Texas Children’s Hospital, Texas Heart Institute, Baylor College of Medicine, Houston, TX. Dr. Patel worked as Chief of adult congenital heart disease, Assistant Professor at the Michigan State University, Grand Rapids, MI where he not only expanded the program, performing complex interventions and device implantations but also established the percutaneous pulmonary valve implantation (Melody Valve) Program. Due to his passion for treating structurally abnormal hearts, he did a dedicated year of Structural Heart Disease fellowship at Henry Ford Hospital, Detroit, MI where he worked with pioneers in this field before moving to North Carolina. He is proficient in performing transcatheter aortic valve replacement (TAVR), MitraClip, Watchman device implantation, percutaneous Mitral, Tricuspid and Pulmonary valve replacements along with a variety of interventions on congenital heart disease and pulmonary hypertension. Dr. Patel is ABIM board certified in Internal Medicine, Cardiology, Interventional cardiology and Adult Congenital Heart Disease. Dr. Patel has more than 50 peer reviewed publications and numerous abstracts to his credit. He serves as a Co-Editor-in-Chief for the CHiP Network journal watch. His wife, Khyati is a pediatric cardiac Electrophysiologist and they have a 9-year-old daughter. Dr. Patel is also an artist, likes music, yoga and plays badminton. His clinical areas of expertise and interests are: 1) Transcatheter therapies for Structural and Adult Congenital heart disease. 2) Complex device implantations.

Dr. Timothy Pirolli is an Assistant Professor of Surgery in the Division of Pediatric Cardiothoracic Surgery at University of Texas Southwestern Medical Center. He specializes in pediatric and adult congenital cardiac surgery. His hospital affiliations include Children’s Medical Center in Dallas, Parkland Memorial Hospital, and Clements University Hospital (UTSW).

Dr. Inga Voges, M.D. Consultant in Pediatric Cardiology, Lead Consultant Cardiovascular MRI. I trained in General Pediatrics and Pediatric Cardiology in Rostock (Germany) and Kiel (Germany) from 2002-2010 and did additional training in Adult Congenital Heart Disease (ACHD) in Kiel (Germany) which I finished in 2014. I specialized in Cardiovascular Magnetic Resonance Imaging (CMR) and have a further special interest in cardiomyopathies. Currently, I am working as a consultant pediatric and ACHD cardiologist at the University Hospital Schleswig-Holstein (Kiel, Germany) where I am responsible for the CMR imaging program in pediatric and ACHD patients and contribute to the care of patients with acquired and congenital heart disease. I received my MD from the Medical University Luebeck in 2006 (Germany) and finished my “Habilitation” (PhD equivalent; University Hospital Kiel, Germany) in 2014. Since 2016, I am the secretary of the Association for European Paediatric and Congenital Cardiology Imaging Working Group.

Dr. Gary Webb, M.D. is an Emeritus Professor of Pediatrics and Internal Medicine at the University of Cincinnati College of Medicine and,
from 2009-2016, the Director of the Adult Congenital Heart Program at Cincinnati Children’s Hospital Heart Institute. A graduate of McGill
University in Montréal, he interned at the Royal Victoria Hospital, and then trained in internal medicine and cardiology at the University of Toronto. From 1980-2004, he was co-director and then director of the Toronto Congenital Cardiac Center for Adults at Toronto General Hospital. He is a Fellow of the Royal College of Physicians and Surgeons of Canada in both internal medicine and cardiology. From 2004-2009, he was director of the Philadelphia Adult Congenital Heart Center at the University of Pennsylvania. Since 2016, he has been a consultant to Cincinnati Children’s Hospital, and has been responsible for the ACHD Learning Center, the Cardiology Fellow Testing Center, and the Congenital Heart Professionals International (CHIP) Network. Since 2017, he has resumed seeing patients on a part-time basis at the Toronto Congenital Cardiac Centre for Adults.

Wendy Whiteside, MD Wendy is Assistant Professor of Pediatrics and Associate Director of Interventional Pediatric Cardiology at the University of Michigan Congenital Heart Center, C.S. Mott Children’s Hospital. She obtained her medical degree from Albert Einstein College of Medicine in 2006 then completed pediatric residency at Children’s Hospital Oakland in Oakland, CA in 2009. She received
both her categorical and interventional pediatric cardiology training at the University of Michigan in Ann Arbor, MI. Her clinical and research interests include single ventricle physiology, transcatheter
pulmonary valves, and quality improvement within the cardiac catheterization laboratory.

About the Congenital Heart and Pediatric Cardiac Journal Watch

Congenital heart and pediatric cardiac Journal Watch was designed to make it easier for congenital heart and pediatric cardiac professionals to keep up with the literature in 6 subsections of congenital heart disease abstracts on a monthly basis: pediatric cardiology; congenital heart surgery; congenital  heart interventions; congenital/pediatric electrophysiology; fetal cardiology; and adult congenital heart disease.

We encourage your continued support as well as your valuable comments and feedback.

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Sincerely,

Dr. Gary Webb, MD and Dr. Mehul Patel
CHiP Network
Congenital Heart and Pediatic Cardiac Journal Watch Editorial Board

The Chip Network, the Congenital Heart International Professionals Network, aims to develop a single global list of all congenital and pediatric cardiac professionals.

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