CHiP Network Congenital Heart Journal Watch – January 2020
Pediatric Cardiology Featured Articles
Pediatric Cardiology Reviews of October- December 2019 Manuscripts
Pediatric Cardiology Review for October-December 2019
Bratt EL, Järvholm S, Ekman-Joelsson BM, Johannsmeyer A, Carlsson SÅ, Mattsson LÅ, Mellander M.
Cardiol Young. 2019 Sep 16:1-7. doi: 10.1017/S1047951119001781. [Epub ahead of print]
PMID: 31522698
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Take Home Points :
- Parents with babies born with congenital heart disease have a high level of anxiety and depression than their matched control groups. There was no difference between the anxiety scores of parents with prenatal vs postnatal diagnosis.
- Life Satisfaction was lower in the parents in the prenatal group and it decreased further during follow up testing after birth, suggesting this group remained vulnerable to poor psychological health.
- Parents in the prenatal group had a lower sense of coherence when compared to controls and upon follow up testing continued to remain so.
- Parents in the postnatal group scored satisfaction with the relationship significantly higher than parents in the control group. The factors underlying this are not clear but may relate to parents coming together and making their life comprehensible, manageable and meaningful.( as evidenced by an increased sense of coherence ).
- Given the risk of adverse psychological health, efforts should focus on improving counseling and support during pregnancy for parents with a fetal diagnosis of congenital heart disease.
Commentary from Dr. Venugopal Amula (Salt Lake City, UT), section editor of Pediatric Cardiology Journal Watch: It is well known that parental stress during pregnancy negatively affects neonatal outcomes and can hamper infant development. In the current study, investigators from the University of Gothenburg, Sweden, study the impact of timing of diagnosis of Congenital Heart Disease (prenatal vs postnatal ) on the psychological health of pregnant women and their partners. Specifically, depression and anxiety, sense of coherence, life satisfaction and satisfaction with partner relationship were studied. Three study groups were included those with a prenatal diagnosis of CHD in offspring (prenatal group), those with a postnatal diagnosis (post-natal group), and a group with uncomplicated pregnancies and deliveries (controls). Patients in the prenatal group were recruited after 22 completed weeks of pregnancy so as not to interfere with the decision to terminate the pregnancy ( the upper limit of GA to allow termination being 22 completed weeks in Sweden). Matching of the groups based on parental age, sex and parity and complexity of CHD was done. Previously validated instruments such as Hospital Anxiety and Depression scale, Sense of Coherence Scale, Life Satisfaction scale and Dyadic Adjustment scale were used. Testing at Time 1 included prenatal group and healthy controls. All three groups were tested at follow up (Time 2) between 2-6 months after delivery.
Pediatric cardiology Nov 2019
Zühlke L, Lawrenson J, Comitis G, De Decker R, Brooks A, Fourie B, Swanson L, Hugo-Hamman C.
Curr Cardiol Rep. 2019 Nov 29;21(12):163. doi: 10.1007/s11886-019-1248-z. Review.
PMID: 31784844
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Manuel V, Miana LA, Guerreiro GP, Tenório DF, Turquetto A, Penha JG, Massoti MR, Tanamati C, Junior APF, Caneo LF, Jatene FB, Jatene MB.
J Card Surg. 2019 Nov 29. doi: 10.1111/jocs.14381. [Epub ahead of print]
PMID: 31782834
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Giuseppe C, Pier Paolo B, Francesco B, Francesco M, Vassilios F, Francesco F, Francesco R.
J Matern Fetal Neonatal Med. 2019 Nov 19:1-211. doi: 10.1080/14767058.2019.1695770. [Epub ahead of print]
PMID: 31744358
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Huggard D, Kelly L, Ryan E, McGrane F, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Doherty DG, Molloy EJ.
Cytokine. 2019 Nov 27;127:154938. doi: 10.1016/j.cyto.2019.154938. [Epub ahead of print]
PMID: 31785499
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Foster CB, Cabrera AG, Bagdure D, Blackwelder W, Moffett BS, Holloway A, Mishcherkin V, Bhutta A.
Cardiol Young. 2019 Nov 26:1-4. doi: 10.1017/S1047951119002671. [Epub ahead of print]
PMID: 31769370
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Silva JA, Neves AL, Flor-de-Lima F, Soares P, Guimarães H.
Pediatr Cardiol. 2019 Nov 25. doi: 10.1007/s00246-019-02239-4. [Epub ahead of print]
PMID: 31768578
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Wang D, Zhang Y, Jiang Y, Ye Y, Ji M, Dou Y, Chen X, Li M, Ma X, Sheng W, Huang G, Yan W; SPCC group.
BMJ Open. 2019 Nov 24;9(11):e031076. doi: 10.1136/bmjopen-2019-031076.
PMID: 31767586 Free PMC Article
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Jakob A, Schachinger E, Klau S, Lehner A, Ulrich S, Stiller B, Zieger B.
Eur J Pediatr. 2019 Nov 23. doi: 10.1007/s00431-019-03513-6. [Epub ahead of print]
PMID: 31760507
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Zhou YA, Li P, Zhang Y, Xiong Q, Li C, Zhao Z, Wang Y, Xiao H.
Mol Genet Genomic Med. 2019 Nov 23:e1058. doi: 10.1002/mgg3.1058. [Epub ahead of print]
PMID: 31758674 Free Article
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Rodriguez-Fanjul J, Tubio-Gómez S, Carretero Bellón JM, Bautista-Rodríguez C, de Toledo JS.
Pediatr Cardiol. 2019 Nov 23. doi: 10.1007/s00246-019-02241-w. [Epub ahead of print]
PMID: 31758211
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Lyu J, Zhao K, Xia Y, Zhao A, Yin Y, Hong H, Li S.
BMC Pregnancy Childbirth. 2019 Nov 21;19(1):429. doi: 10.1186/s12884-019-2541-y.
PMID: 31752736 Free Article
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Alkuraya H, Patel N, Ibrahim N, Al Ghamdi B, Alsulaiman SM, Nowilaty SR, Abboud E, Alturki R, Alkharashi A, Eyaid W, Almasseri Z, Alzaidan H, Alotaibi MD, Abu El-Asrar AM, Alamro B, Helaby R, Elshaer A, Almontashiri NAM, Al-Hussaini AA, Alkuraya FS.
Clin Genet. 2019 Nov 15. doi: 10.1111/cge.13676. [Epub ahead of print]
PMID: 31730227
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Baker MG, Gurney J, Oliver J, Moreland NJ, Williamson DA, Pierse N, Wilson N, Merriman TR, Percival T, Murray C, Jackson C, Edwards R, Foster Page L, Chan Mow F, Chong A, Gribben B, Lennon D.
Int J Environ Res Public Health. 2019 Nov 15;16(22). pii: E4515. doi: 10.3390/ijerph16224515.
PMID: 31731673 Free PMC Article
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Brudy L, Hock J, Häcker AL, Meyer M, Oberhoffer R, Hager A, Ewert P, Müller J.
J Pediatr. 2019 Nov 15. pii: S0022-3476(19)31314-9. doi: 10.1016/j.jpeds.2019.09.077. [Epub ahead of print]
PMID: 31740142
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Neumann L, Springer T, Nieschke K, Kostelka M, Dähnert I.
Pediatr Cardiol. 2019 Nov 15. doi: 10.1007/s00246-019-02230-z. [Epub ahead of print]
PMID: 31729543
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Mishra TA, Sharma P.
J Nepal Health Res Counc. 2019 Nov 13;17(3):288-292. doi: 10.33314/jnhrc.v17i3.1789.
PMID: 31735919
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Gramszlo C, Karpyn A, Demianczyk AC, Shillingford A, Riegel E, Kazak AE, Sood E.
J Pediatr. 2019 Nov 12. pii: S0022-3476(19)31294-6. doi: 10.1016/j.jpeds.2019.09.059. [Epub ahead of print]
PMID: 31735417
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Giuseppe C, Pier Paolo B, Francesco B, Francesco M, Vassilios F, Francesco F, Francesco R.
J Matern Fetal Neonatal Med. 2019 Nov 19:1-211. doi: 10.1080/14767058.2019.1695770. [Epub ahead of print]
PMID: 31744358
Select item 31745583
Zheng Y, Peng Y, Zhang S, Li L, Peng Y, Yin Q.
Front Genet. 2019 Nov 5;10:1088. doi: 10.3389/fgene.2019.01088. eCollection 2019.
PMID: 31749841 Free PMC Article
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Kloster S, Tolstrup JS, Olsen MS, Johnsen SP, Søndergaard L, Nielsen DG, Ersbøll AK.
J Am Heart Assoc. 2019 Nov 5;8(21):e013491. doi: 10.1161/JAHA.119.013491. Epub 2019 Oct 28.
PMID: 31656122 Free Article
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Marino LV, Johnson MJ, Davies NJ, Kidd CS, Fienberg J, Richens T, Bharucha T, Beattie RM, Darlington AE.
Clin Nutr. 2019 Nov 2. pii: S0261-5614(19)33124-3. doi: 10.1016/j.clnu.2019.10.031. [Epub ahead of print]
PMID: 31734051 Free Article
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Payne RM, Burns KM, Glatz AC, Li D, Li X, Monagle P, Newburger JW, Swan EA, Wheaton O, Male C; Pediatric Heart Network Investigators.
Am Heart J. 2019 Nov;217:52-63. doi: 10.1016/j.ahj.2019.08.002. Epub 2019 Aug 9.
PMID: 31493728
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Kelly CJ, Arulkumaran S, Tristão Pereira C, Cordero-Grande L, Hughes EJ, Teixeira RPAG, Steinweg JK, Victor S, Pushparajah K, Hajnal JV, Simpson J, Edwards AD, Rutherford MA, Counsell SJ.
Arch Dis Child. 2019 Nov;104(11):1042-1048. doi: 10.1136/archdischild-2018-314822. Epub 2019 Jun 26.
PMID: 31243012 Free PMC Article
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Sallmon H, Moledina S, Albert DC, Beghetti M, Berger RMF, Bonnet D, Bukova M, Koestenberger M, Meinel K, Reinhardt Z, Tulloh RMR, de Wolf D, Hansmann G.
Cardiol Young. 2019 Nov;29(11):1323-1327. doi: 10.1017/S104795111900235X. Epub 2019 Sep 26.
PMID: 31554525
Select item 31522698
Bratt EL, Järvholm S, Ekman-Joelsson BM, Johannsmeyer A, Carlsson SÅ, Mattsson LÅ, Mellander M.
Cardiol Young. 2019 Nov;29(11):1328-1334. doi: 10.1017/S1047951119001781. Epub 2019 Sep 16.
PMID: 31522698
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Deng X, Jin B, Li S, Li Y, Zhou H, Wu Y, Yan M, Hu Y, Qiu Q, Zhang G, Zheng X.
Clin Respir J. 2019 Nov;13(11):693-699. doi: 10.1111/crj.13076. Epub 2019 Aug 29.
PMID: 31419027
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Havelund KW, Hulgaard M, Malberg D, Fenger-Gron J.
Dan Med J. 2019 Nov;66(11). pii: A5576.
PMID: 31686645
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Montis S, Sirigu D, Marini A, Lai A, Setti P, Camboni M, Mura GC, Congia M, Manca D, Marini E, Merola A, Orrù L, Scano F, Stara R, Urru M, Tumbarello R.
G Ital Cardiol (Rome). 2019 Nov;20(11):651-657. doi: 10.1714/3254.32226. Italian.
PMID: 31697272
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Russo MG, Cirillo A, Rinelli G, Vairo U, Favilli S, Moreo A, Domenicucci S, Gulizia MM, Gabrielli D.
G Ital Cardiol (Rome). 2019 Nov;20(11):627-631. doi: 10.1714/3254.32223. Italian.
PMID: 31697269
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Zhao Z, Zhan Y, Chen W, Ma X, Sheng W, Huang G.
Genesis. 2019 Nov;57(11-12):e23333. doi: 10.1002/dvg.23333. Epub 2019 Sep 12.
PMID: 31513339
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Siaplaouras J, Apitz C.
J Cardiopulm Rehabil Prev. 2019 Nov;39(6):E35. doi: 10.1097/HCR.0000000000000487. No abstract available.
PMID: 31688514
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Wu J, Li J, Liu H, Yin J, Zhang M, Yu Z, Miao H.
J Clin Lab Anal. 2019 Nov;33(9):e22998. doi: 10.1002/jcla.22998. Epub 2019 Aug 20.
PMID: 31429492 Free PMC Article
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Abdel Razek AAK, Al-Marsafawy H, Elmansy M.
J Comput Assist Tomogr. 2019 Nov/Dec;43(6):906-911. doi: 10.1097/RCT.0000000000000938. Review.
PMID: 31738213
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Haxel C, Glickstein J, Parravicini E.
J Pediatr. 2019 Nov;214:79-88. doi: 10.1016/j.jpeds.2019.07.044.
PMID: 31655705
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Zaban NB, Przybylowski LF, Schamberger MS.
J Pediatr. 2019 Nov;214:33. doi: 10.1016/j.jpeds.2019.05.015. No abstract available.
PMID: 31655702
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- Pediatric Hemoptysis without Bronchiectasis or Cardiac Disease: Etiology, Recurrence, and Mortality.
Chiel L, Welsh S, Andren K, Mecklosky J, Alexander PMA, Casey A, Fishman MP.
J Pediatr. 2019 Nov;214:66-70. doi: 10.1016/j.jpeds.2019.07.049. Epub 2019 Sep 17.
PMID: 31540762
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Gakenheimer-Smith L, Glotzbach K, Ou Z, Presson AP, Puchalski M, Jones C, Lambert L, Delgado-Corcoran C, Eckhauser A, Miller T.
J Pediatr. 2019 Nov;214:71-78.e2. doi: 10.1016/j.jpeds.2019.06.047. Epub 2019 Aug 8.
PMID: 31402138
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Hames DL, Ferguson MA, Kaza AK, Rajagopal S, Thiagarajan RR, Teele SA, Salvin JW.
J Thorac Cardiovasc Surg. 2019 Nov;158(5):1446-1455. doi: 10.1016/j.jtcvs.2019.06.061. Epub 2019 Jul 10.
PMID: 31395365
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Secchi F, Chessa M, Petrini M, Monti CB, Alì M, Cannaò PM, Di Leo G, Sardanelli F.
J Thorac Imaging. 2019 Nov;34(6):380-386. doi: 10.1097/RTI.0000000000000400.
PMID: 30870306
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Li XY, Chen K, Lv ZT.
Medicine (Baltimore). 2019 Nov;98(45):e17653. doi: 10.1097/MD.0000000000017653.
PMID: 31702616 Free PMC Article
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Davis JAM, Bass A, Humphrey L, Texter K, Garee A.
Pediatr Cardiol. 2019 Nov 1. doi: 10.1007/s00246-019-02231-y. [Epub ahead of print]
PMID: 31676955
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Kulik LA, Hasbani NR, Stellar JJ, Quigley SM, Shelley SS, Wypij D, Curley MAQ; for Braden QD Study Group.
Pediatr Crit Care Med. 2019 Nov;20(11):1048-1056. doi: 10.1097/PCC.0000000000002077.
PMID: 31385861
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Tadros HJ, Gupta D, Childress M, Beasley G, Rubrecht AE, Shenoy A, Philip J, Bleiweis MS, Machado DS.
Pediatr Transplant. 2019 Nov;23(7):e13567. doi: 10.1111/petr.13567. Epub 2019 Aug 13.
PMID: 31407854
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Calderon J, Bellinger DC, Newburger JW.
Pediatrics. 2019 Nov;144(5). pii: e20192752. doi: 10.1542/peds.2019-2752. Epub 2019 Oct 10. No abstract available.
PMID: 31601612
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Sigmon ER, Kelleman M, Susi A, Nylund CM, Oster ME.
Pediatrics. 2019 Nov;144(5). pii: e20184114. doi: 10.1542/peds.2018-4114. Epub 2019 Oct 10.
PMID: 31601611
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Wen H, Zhang R, Li Y, Qian H, Yan Z, Chen Y, Li G.
Per Med. 2019 Nov;16(6):449-455. doi: 10.2217/pme-2018-0154. Epub 2019 Nov 6.
PMID: 31691635
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Evans WN, Acherman RJ, Ciccolo ML, Lehoux J, Rothman A, Galindo A.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):702-706. doi: 10.1177/2150135119873847.
PMID: 31701835
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Bates KE, Connor J, Chanani NK, McLellan MC, McCormick A, Smith-Parrish M, Moga MA.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):733-741. doi: 10.1177/2150135119881393. Epub 2019 Oct 30.
PMID: 31663842
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Ryan KR, Jones MB, Allen KY, Marino BS, Casey F, Wernovsky G, Lisanti AJ.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):750-758. doi: 10.1177/2150135119878702. Epub 2019 Oct 28.
PMID: 31658880
Howard A, Hasan A, Brownlee J, Mehmood N, Ali M, Mehta S, Fergie J.
Pediatr Cardiol. 2019 Nov 30. doi: 10.1007/s00246-019-02258-1. [Epub ahead of print]
PMID: 31786619
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Li Y, Williams RJ, Dombrowski ND, Watters K, Daly KP, Irace AL, Visner GA, Rahbar R, Fynn-Thompson F.
Int J Pediatr Otorhinolaryngol. 2019 Nov 29;130:109799. doi: 10.1016/j.ijporl.2019.109799. [Epub ahead of print]
PMID: 31812839
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Mühlstädt K, De Backer J, von Kodolitsch Y, Kutsche K, Muiño Mosquera L, Brickwedel J, Girdauskas E, Mir TS, Mahlmann A, Tsilimparis N, Staebler A, Schoof L, Seidel H, Berger J, Bernhardt AM, Blankenberg S, Kölbel T, Detter C, Szöcs K, Kaemmerer H.
J Clin Med. 2019 Nov 29;8(12). pii: E2079. doi: 10.3390/jcm8122079.
PMID: 31795342 Free Article
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Ezekian JE, Hill KD.
Curr Cardiol Rep. 2019 Nov 28;21(12):162. doi: 10.1007/s11886-019-1229-2. Review.
PMID: 31781972
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Shao S, Luo C, Zhou K, Hua Y, Wu M, Liu L, Liu X, Wang C.
Pediatr Rheumatol Online J. 2019 Nov 27;17(1):78. doi: 10.1186/s12969-019-0379-5.
PMID: 31775782 Free PMC Article
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Mazurak M, Kusa J.
Arch Dis Child. 2019 Nov 26. pii: archdischild-2019-318044. doi: 10.1136/archdischild-2019-318044. [Epub ahead of print] No abstract available.
PMID: 31771944
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Sunthankar S, Parra DA, George-Durrett K, Crum K, Chew JD, Christensen J, Raucci FJ, Xu M, Slaughter JC, Soslow JH.
Cardiol Young. 2019 Nov 26:1-9. doi: 10.1017/S1047951119002397. [Epub ahead of print]
PMID: 31769372
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Foster CB, Cabrera AG, Bagdure D, Blackwelder W, Moffett BS, Holloway A, Mishcherkin V, Bhutta A.
Cardiol Young. 2019 Nov 26:1-4. doi: 10.1017/S1047951119002671. [Epub ahead of print]
PMID: 31769370
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Slostad BD, Witt CM, O’Leary PW, Maleszewski JJ, Scott CG, Dearani JA, Pellikka PA.
Circulation. 2019 Nov 26;140(22):1853-1855. doi: 10.1161/CIRCULATIONAHA.119.041835. Epub 2019 Nov 25. No abstract available.
PMID: 31765262
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Geva A, Abman SH, Manzi SF, Ivy DD, Mullen MP, Griffin J, Lin C, Savova GK, Mandl KD.
J Am Med Inform Assoc. 2019 Nov 26. pii: ocz194. doi: 10.1093/jamia/ocz194. [Epub ahead of print]
PMID: 31769835
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Motz P, Von Saint Andre Von Arnim A, Iyer RS, Chabra S, Likes M, Dighe M.
J Perinat Med. 2019 Nov 26;47(9):991-996. doi: 10.1515/jpm-2019-0198.
PMID: 31605580
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Harrison MJ, Zühlke LJ, Lewandowski LB, Scott C.
Pediatr Rheumatol Online J. 2019 Nov 26;17(1):76. doi: 10.1186/s12969-019-0382-x.
PMID: 31771606 Free PMC Article
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Serrano RM, Rodefeld MD, Alexy R.
Cardiol Young. 2019 Nov 25:1-3. doi: 10.1017/S1047951119002555. [Epub ahead of print]
PMID: 31760959
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Coffman Z, Steflik D, Chowdhury SM, Twombley K, Buckley J.
J Perinatol. 2019 Nov 25. doi: 10.1038/s41372-019-0560-1. [Epub ahead of print]
PMID: 31767977
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Kavurt AV, Paç FA, Koca S, Mutlu Mıhçıoğlu A, Yiğit H.
Echocardiography. 2019 Nov 22. doi: 10.1111/echo.14532. [Epub ahead of print]
PMID: 31755582
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Geva A, Abman SH, Manzi SF, Ivy DD, Mullen MP, Griffin J, Lin C, Savova GK, Mandl KD.
J Am Med Inform Assoc. 2019 Nov 26. pii: ocz194. doi: 10.1093/jamia/ocz194. [Epub ahead of print]
PMID: 31769835
Select item 31773636
Alshami N, Sarvestani AL, Thomas AS, St Louis J, Kochilas L, Raghuveer G.
Pediatr Cardiol. 2019 Nov 16. doi: 10.1007/s00246-019-02234-9. [Epub ahead of print]
PMID: 31734750
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Ramaswami U, Futema M, Bogsrud MP, Holven KB, Roeters van Lennep J, Wiegman A, Descamps OS, Vrablik M, Freiberger T, Dieplinger H, Greber-Platzer S, Hanauer-Mader G, Bourbon M, Drogari E, Humphries SE.
Atherosclerosis. 2019 Nov 15;292:178-187. doi: 10.1016/j.atherosclerosis.2019.11.012. [Epub ahead of print]
PMID: 31809987 Free Article
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Asagai S, Inai K, Shimada E, Harada G, Sugiyama H.
Pediatr Cardiol. 2019 Nov 11. doi: 10.1007/s00246-019-02249-2. [Epub ahead of print]
PMID: 31712861
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Roberts RO 3rd, Di Maria MV, Brigham D, Hsu S.
Pediatr Cardiol. 2019 Nov 9. doi: 10.1007/s00246-019-02248-3. [Epub ahead of print]
PMID: 31707491
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Dionne A, Dahdah N, Singh-Grewal D, Burgner DP, Newburger JW, de Ferranti SD.
Int J Cardiol. 2019 Nov 2. pii: S0167-5273(19)34308-6. doi: 10.1016/j.ijcard.2019.10.045. [Epub ahead of print]
PMID: 31753581
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Bradley-Hewitt T, Longenecker CT, Nkomo V, Osborne W, Sable C, Scheel A, Zühlke L, Watkins D, Beaton A.
Cardiol Young. 2019 Nov;29(11):1387-1390. doi: 10.1017/S1047951119002270. Epub 2019 Oct 1.
PMID: 31571555
Select item 31566150
Yurttutan S, Bozkaya A, Hüdayioglu F, Oncel MY.
J Matern Fetal Neonatal Med. 2019 Nov;32(21):3662-3665. doi: 10.1080/14767058.2018.1481043. Epub 2018 Jun 19.
PMID: 29921134
ACHD Featured Articles in association with ISACHD
ACHD Cardiology Reviews of October-December 2019 Manuscripts
Adult Congenital Heart Reviews of October – December 2019 Manuscripts provided by ISACHD
Maagaard M, Heiberg J, Redington AN, Hjortdal VE.
Eur J Cardiothorac Surg. 2019 Oct 18. pii: ezz278. doi: 10.1093/ejcts/ezz278. [Epub ahead of print]
PMID: 31625565
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Take Home Points:
- In young adults with small unrepaired ventricular septal defects (VSD), exercise capacity is diminished when compared with healthy controls, which can be explained by reduced biventricular contractility at rest and during exercise.
- Specifically, tissue Doppler parameters of left ventricle (LV) systolic function, including Isovolumetric acceleration (IVA), are diminished both at rest and during exercise in VSD patients when compared with healthy controls. Thus, LV contractile reserve is progressively decreased at higher workloads in VSD patient.
- Patients with small unrepaired VSD are at increased risk of long-term complications and should be followed in adult congenital heart centers.
Commentary from Dr. Maan Jokhadar (Atlanta GA), section editor of ACHD Journal Watch: Recent studies have demonstrated reduced exercise capacity in young patients with unrepaired small ventricular septal defects (shunt fraction < 1.5) and this is thought to be due to ventricular dysfunction from a small shunt over a prolonged period of time.
Ventricular force – frequency relationships can be studied noninvasively using tissue Doppler techniques to reflect the dynamic myocardial response to exercise.
This elegant study was conducted by Dr. Maagaard and colleagues from Aarhus, Denmark in collaboration with Dr. Redington in Cincinnati, OH, USA. They studied 34 unrepaired VSD patients and 28 healthy controls between the ages of 18 and 40. In the VSD group, 9 were muscular and 23 were perimembranous. All participants had normal resting ejection fraction, tricuspid regurgitation velocity less than 2.8 cm/sec, normal right atrial pressure, and no measurable aortic insufficiency. The average age was 27 years and baseline characteristics were comparable in the patient and control group, including height, weight, gender, body mass index, heart rate, blood pressure, as well as comparable daily exercise levels.
All patients in the small VSD group had isolated VSD without prior surgical intervention and no associated congenital heart disease, arrhythmia, or syndrome. The median shunt fraction was 1.2.
All participants had bicycle exercise echocardiogram with longitudinal incremental tissue Doppler imaging with workload increased until exhaustion. Tissue Doppler measurements were obtained in the apical 4 chamber from the basal septum and basal free walls of the LV and RV.
At baseline, IVA was lower in VSD patients compared with controls in the septum, LV, and RV. LV and RV peak S’ was also lower in VSD patients. However, septal S’, E’, and A’ were similar between VSD patients and controls.
During supine bicycle ergometry, force-frequency relationship curves of IVA in VSD patients were lower than controls in the septum, RV, and LV. This difference increased with intensifying workload. IVV and S’ of the RV, LV, and septum were also lower in VSD patients during exercise.
Smaller shunts had higher LV IVA but this inverse relationship was not true for the septum or RV. Higher RV S’ correlated with better exercise capacity in VSD patients but not in controls.
These findings may be explained by the increased left ventricle volume loading that occurs, even with small shunts over a long period of time. Clearly, even small shunts may be hemodynamically significant in the long run because of the increased LV volume load, left atrial dilation, and amplification of diastolic dysfunction with age. Though a lower threshold for VSD closure could potentially mitigate or avoid the adverse changes associated with small shunts, additional studies are needed before such a conclusion can be reached. However, this study does bolster the argument that unrepaired VSD patients should be followed by a specialized center for adult congenital patients.
This important study adds to the growing body of literature regarding the long-term hemodynamic consequences of unrepaired VSD and increases our understanding in this area.
Tissue Doppler Parameters during systole and diastole
AT: Acceleration time (sec)
IVV: Isovolumetric velocity (cm/sec)
IVA: Isovolumetric acceleration (cm/sec2)
IVA = IVV/AT (cm/sec2)
Peak S’ velocity (cm/sec)
IVCT: Isovolumetric contraction
IVRT: Isovolumetric relaxation
E’: Early relaxation
A’: Associated with atrial contraction
ET: ejection time
Broda CR, Salciccioli KB, Lopez KN, Ermis PR, Moodie DS, Dickerson HA.
Congenit Heart Dis. 2019 Oct 16. doi: 10.1111/chd.12856. [Epub ahead of print]
PMID: 31617655
Select item 31578117
Take Home Points:
- First study to assess clinical outcomes in adult patients with heterotaxy syndrome and CHD.
- The risk for early death, transplantation and co-morbidities remains high.
- Median survival of 54% at age 40.
- No congenital anatomic factors (ventricular status or HS type) were associated with reduced survival.
- Heart failure portends a worse prognosis.
- Nearly all patients had developed tachyarrythmias by age 50.
- 20% of patients experienced cerebrovascular accidents at point of last follow-up.
- In patients born after January 1985, intervention, including Fontan completion occurred at an earlier age.
Commentary from Dr. Blanche Cupido (Cape Town, South Africa), section editor of ACHD Journal Watch: Heterotaxy syndrome is a condition characterized by the abnormal lateral arrangement of thoraco-abdominal organs, and frequently associated with complex congenital heart disease (CHD). Even in the contemporary era, morbidity and mortality remains high. Very little is known about this condition relating to CHD in adults with data currently being extrapolated from paediatric data.
This is a single tertiary center (Texas, US) retrospective folder review of adult patients between 1968 and 2018. They aimed to describe the sociodemographics and clinical outcomes in adult patients with heterotaxy syndrome and congenital heart disease.
Patients were excluded if they had situs inversus totalis, or without thoraco-abdominal laterality defect. The group was then subdivided based on splenic anatomy. A total of 62 patients met the inclusion criteria.
Of the 62 patients included, 29% (n=18) had heterotaxy syndrome with polysplenia (HS-PS), 46.7% (n=29) had heterotaxy syndrome with asplenia (HS-AS). The remaining patients had insufficient data to define splenic anatomy. The median age of the cohort was 22.7 years and 41.9% were female. Twelve (19.3%) were transplanted or dead – average age of this subgroup was 28.8 years. Three men had fathered children and one female with a Fontan circulation successfully carried a pregnancy to term.
Thirty-six interventions occurred in 24 patients after age 18 – 16 were cardiac catheterization lab interventions (angioplasty or stenting, device or coil placement, pericardiocentesis, Fontan fenestration, electrophysiology procedures). Eighteen surgical procedures occurred – Epicardial pacing, pulmonary artery plication/augmentation, Maze procedure, AV valve preplacement, Fontan conversion and heart transplant.
Forty-three patients had single ventricles of which 71% had Fontan palliations.
Twelve deaths occurred in total, 10 were pre-transplant. The overall transplant-free survival was 98.1% at age 20, 83.5% at age 30 and 54.2% at age 40 years. (Figure 1 below). Of all parameters, only systemic outflow obstruction neared statistical significance as a predictor for poor outcome. Neither ventricular status, nor HS type predicted survival disadvantage.
Heart failure was seen in 29.8% (n=17/57). Those with heart failure by age 18 were more likely to die or receive transplantation with time to outcome of 2.6 years. Heart failure survival was 80.8%,58.7% and 31.1% at 20, 30 and 40 years respectively. (See figure 2 below)
By age 18, 46.2% had no arrythmia, 25% had experienced tachyarrythmias, 17.3% had bradyarrhythmia and 11.5% experienced both tachy-and bradyarrythmias. Bradycardia-free survival was 33% at age 40. (Figure 3 below). Bradycardia was not associated with a transplant-free survival disadvantage compared to no arrythmia.
Tachycardia proved a survival disadvantage with a HR 6.48 (95% CI 1.41-29.75, p=0.016). The median age of tachycardia-free survival was 54%, 29.2% and 19.5% at 20,30 and 40 years respectively (Figure 3).
Cerebrovascular accidents (CVA) occurred in 22.4% of patients (n=13), 7 occurring before the age of age 18. CVA was associated with transplant-free survival disadvantage (HR 7.97, 95% CI 1.93-32.99, p=0.004). CVA free survival was 84.3%, 54.2% and 40.6% at 20,30 and 40 years respectively (See Figure 4)
Patients were stratified by ‘era’: Early era included those born before age January 1985, and the late era were those born after January 1985. Late era patients had earlier median age of Fontan completion (6.3 vs 15 years, p=0.002).
All-cause mortality and survival in adults with 22q11.2 deletion syndrome.
Van L, Heung T, Graffi J, Ng E, Malecki S, Van Mil S, Boot E, Corral M, Chow EWC, Hodgkinson KA, Silversides C, Bassett AS.
Genet Med. 2019 Oct;21(10):2328-2335. doi: 10.1038/s41436-019-0509-y. Epub 2019 Apr 5.
PMID: 30948858 Free PMC Article
Select item 31315938
Take Home Points:
- 2 deletion is the most common microdeletion syndrome and frequently encountered in patients with congenital heart disease – particularly conotruncal anomalies.
- Little is known about the longer-term survival of adult patients with 22q11.2 deletion syndrome.
- This was a retrospective review of 309 adults with 22q11.2 deletion syndrome and their 1014 unaffected parents/siblings.
- 2 deletion syndrome is associated with almost 9x independent risk of mortality compared to siblings without 22q11.2. (HR 8.86, 95% CI 2.87-27.37).
- Of the patients with 22q11.2 deletion there were 31 deaths at a median age of 46 years (range 18 -69 years).
- As one would expect, patients with ‘major ‘congenital heart disease had shorter survival than patients with non-major congenital heart disease.
- Probability of survival of patients with 22q11.2 and major congenital heart disease to live to age 40 and 50 years was approximately 82% and 63% vs 98% and 85% in patients without major congenital heart disease.
Commentary from Dr. Damien Cullington (Liverpool, UK), section editor of ACHD Journal Watch: 22q11.2 deletion syndrome is thought to be inherited in 1 in 3000-4000 live births. Penetrance is very high but with wide phenotypic variability. There has been little investigation of the importance of 22q11.2 deletion in adults and this retrospective analysis sought to address what implications 22q11.2 has on survival in affected subjects compared to their siblings/parents.
Patient demographics and outcomes
Patients were identified from a specialty clinic for adults with 22q11.2, via referrals or screening of patients with congenital heart disease (CHD). Over four fifths of patients were Caucasian (n=260) and 52% (n=161) were women. 469 siblings and 545 parents without 22q11.2 were enrolled as comparators. ‘Major’ congenital heart disease (n=112) was defined as persons with at least moderate complexity CHD, most of whom had tetralogy of Fallot (n=80). 309 subjects >17 years old with 22q11.2 deletion agreed to participate – of these, just over a third (n=112) had ‘major’ CHD.
The primary outcome measure was all cause mortality. Medical records and postmortem studies were reviewed to establish cause of death. Follow up was for a relatively modest median period of 5.3 years (range 0.1-21.5 years). During follow up, 31 subjects with 22q11.2 deletion died at a median age of 46 years old (range 18-69 years) – mostly resulting from cardiac causes (n=22) (Table 1). In comparison, 6 subjects without 22q11.2 deletion died at a median age of 58 years old (range 24-83 years old).
Controlling for other significant co-variables (such as the presence of major CHD), there was an independent relationship between survival and presence of a 22q11.2 microdeletion (Table 2). Subjects with 22q11.2 deletion had worse survival if they had ‘major’ CHD versus ‘non-major’ CHD (Figure 1).
Table 1 Cause of death in 31 adults with 22q11.2 deletion syndrome and relationship to CHD complexity
Table 2 Cox regression models for mortality risk in 309 adults with 22q11.2 deletion syndrome
Figure 1
Conclusions
This analysis is reported to be the largest study of adult patients with 22q11.2 deletion to assess longer term survival compared to siblings and their parents not known to have 22q11.2 deletion. 22q11.2 microdeletion is a significant, independent risk factor for shorter survival. There is interesting, emerging data that rare, biallelic pathogenic variants of the TANGO2 gene within the 22q11.2 region may be associated with a more ‘malignant’ phenotype connected to sudden cardiac death and unexpected death in epilepsy. As one may expect, subjects with a 22q11.2 deletion plus major CHD had worse survival than those with milder forms of CHD.
Larger cohorts with longer term follow up is required to gather a more complete picture of the significance of 22q11.2 deletion syndrome in relation to survival. Compared to earlier analyses, median age of death in patients with 22q11.2 appears to be increasing which is reassuring.
Exercise Capacity in Asymptomatic Adult Patients Treated for Coarctation of the Aorta.
Dijkema EJ, Sieswerda GT, Breur JMPJ, Haas F, Slieker MG, Takken T.
Pediatr Cardiol. 2019 Oct;40(7):1488-1493. doi: 10.1007/s00246-019-02173-5. Epub 2019 Aug 7.
PMID: 31392380 Free PMC Article
Select item 31367952
Take Home Points:
- Exercise capacity was normal in a small group of adults > 20 years post repair of coarctation of the aorta.
- Resting hypertension was present is 59 % (13/22) while exercise-induced hypertension was detected in 82 % (18/22).
- Amongst normotensive subjects, exercise-induced hypertension occurred in 78 % (7/9).
- Surveillance of exercise-induced hypertension with cardiopulmonary exercise testing as a precursor to chronic hypertension can be considered for its early detection.
Commentary from Dr. Timothy Roberts (Melbourne, Australia), section editor of ACHD Journal Watch: Exercise capacity is reduced in adults with congenital heart disease (CHD), although those with repaired coarctation of the aorta (CoA) are thought to have the least – if any – impairment relative to other forms of complex CHD. Meanwhile hypertension remains a lifelong risk in repaired CoA, due to reduced aortic compliance, impaired baroceptor function, and abnormal wall-shear stress dynamics. Isolated exercise-induced hypertension may be a predictor for the future development of chronic hypertension.
The aims of this singe centre prospective study were to assess (1) exercise capacity, and (2) blood pressure response in adults with repaired CoA in relation to left ventricular and vascular function.
Study participation involved cardiopulmonary exercise testing (CPET) and cardiac MRI. Inclusion criteria were a history a CoA with primary treatment (surgical or balloon angioplasty without stenting) performed between ages 3 months to 16 years, and more than 10 years of follow-up. Exclusion criteria were isthmus or aortic arch hypoplasia, and severe associated CHD lesions. A ‘control group’ for exercise data was constructed using a large Dutch database.
A total of 72 patients met criteria, of which only 22 (31 %) agreed to participate. Patient demographics, and CPET results are shown in the tables below:
Exercise capacity was normal (VO2peak 41.7 +/- 12 ml/kg/min) in the CoA cohort. Exercise-induced hypertension was common (82 %), and of the 9 normotensive subjects, 7 (78 %) demonstrated exercise-induced hypertension. Peak exercise blood pressure was correlated to LV mass, 24-hour ambulatory systolic blood pressure, and systemic hypertension. Multiple regression analysis was attempted to identify predictors of VO2peak and not surprisingly identified male sex and age as significant predictors; a number of additional factors were included but the small sample size would make it highly unlikely to find additional significant associations (whilst being statistically inappropriate).
This study is limited by the small sample size, low recruitment rate, inevitable risk for selection bias in an exercise-based study, and the absence of a true control cohort. Nevertheless, it does demonstrate a large proportion of normotensive repaired CoA subjects to display exercise-induced hypertension. Although the significance of such a finding remains debated, these patients may benefit from more frequent blood pressure assessments to enable earlier detection of chronic hypertension. Exercise testing to assess for exercise-induced hypertension carries a Class IIb recommendation in the 2018 AHA/ACC Guidelines for the Management of Adults With Congenital Heart Disease.
ACHD Nov 2019
Yong MS, Zhu MZL, Huang L, Griffiths S, Brink J, Brizard CP, d’Udekem Y, Konstantinov IE.
Ann Thorac Surg. 2019 Nov 30. pii: S0003-4975(19)31818-1. doi: 10.1016/j.athoracsur.2019.10.030. [Epub ahead of print]
PMID: 31794738
Select item 31784844
Mühlstädt K, De Backer J, von Kodolitsch Y, Kutsche K, Muiño Mosquera L, Brickwedel J, Girdauskas E, Mir TS, Mahlmann A, Tsilimparis N, Staebler A, Schoof L, Seidel H, Berger J, Bernhardt AM, Blankenberg S, Kölbel T, Detter C, Szöcs K, Kaemmerer H.
J Clin Med. 2019 Nov 29;8(12). pii: E2079. doi: 10.3390/jcm8122079.
PMID: 31795342 Free Article
Select item 31781932
Dellborg M, Mandalenakis Z.
Int J Cardiol. 2019 Nov 19. pii: S0167-5273(19)34897-1. doi: 10.1016/j.ijcard.2019.11.117. [Epub ahead of print] No abstract available.
PMID: 31767386
Select item 31746147
Alizadehasl A, Saedi S, Ganji H, Pourafkari L.
Int J Rheum Dis. 2019 Nov 19. doi: 10.1111/1756-185X.13742. [Epub ahead of print]
PMID: 31746147
Select item 31726960
Wong K, Tecson K, Cedars A.
J Am Heart Assoc. 2019 Nov 19;8(22):e014088. doi: 10.1161/JAHA.119.014088. Epub 2019 Nov 13.
PMID: 31718438 Free Article
Select item 31746096
Turgay Yıldırım Ö, Aydın F, Hüseyinoğlu Aydın A, Akşit E.
Int J Cardiol. 2019 Nov 27. pii: S0167-5273(19)35200-3. doi: 10.1016/j.ijcard.2019.11.142. [Epub ahead of print] No abstract available.
PMID: 31806279
Select item 31769370
Roseman A, Kovacs AH.
Curr Cardiol Rep. 2019 Nov 22;21(11):145. doi: 10.1007/s11886-019-1237-2. Review.
PMID: 31758344
Select item 31758312
de Hosson M, De Backer J, De Wolf D, De Groote K, Demulier L, Mels S, Vandekerckhove K, Goossens E.
Eur J Pediatr. 2019 Nov 22. doi: 10.1007/s00431-019-03515-4. [Epub ahead of print]
PMID: 31758312
Select item 31723115
Massalha S, Almufleh A, Walpot J, Ratnayake I, Qureshi R, Abbass T, Pena E, Inacio J, Rybicki FJ, Small G, Crean A, Chow BJW.
J Cardiovasc Comput Tomogr. 2019 Nov 21. pii: S1934-5925(19)30162-5. doi: 10.1016/j.jcct.2019.11.003. [Epub ahead of print]
PMID: 31787590
Select item 31766426
Hilscher MB, Kamath PS.
Clin Liver Dis (Hoboken). 2019 Nov 6;14(4):138-141. doi: 10.1002/cld.828. eCollection 2019 Oct. Review. No abstract available.
PMID: 31709041 Free PMC Article
Select item 31692272
Konno R, Tatebe S, Sugimura K, Satoh K, Aoki T, Miura M, Suzuki H, Yamamoto S, Sato H, Terui Y, Miyata S, Adachi O, Kimura M, Saiki Y, Shimokawa H.
PLoS One. 2019 Nov 19;14(11):e0225403. doi: 10.1371/journal.pone.0225403. eCollection 2019.
PMID: 31743362 Free PMC Article
Select item 31742724
Kuijpers JM, Vaartjes I, Bokma JP, van Melle JP, Sieswerda GT, Konings TC, Boo MB, van der Bilt I, Voogel B, Zwinderman AH, Mulder BJM, Bouma BJ.
Int J Cardiol. 2019 Nov 18. pii: S0167-5273(19)32104-7. doi: 10.1016/j.ijcard.2019.11.114. [Epub ahead of print]
PMID: 31767384
Select item 31812566
Hartopo AB, Anggrahini DW, Nurdiati DS, Emoto N, Dinarti LK.
Pulm Circ. 2019 Nov 18;9(4):2045894019884516. doi: 10.1177/2045894019884516. eCollection 2019 Oct-Dec.
PMID: 31798834 Free PMC Article
Select item 31736331
Gewillig M, Van De Bruaene A.
Circulation. 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044512. [Epub ahead of print]
PMID: 31736331
Select item 31738929
McLaughlin VV, Channick R, De Marco T, Farber HW, Gaine S, Galié N, Krasuski RA, Preston I, Souza R, Coghlan JG, Frantz RP, Hemnes A, Kim NH, Lang IM, Langleben D, Li M, Sitbon O, Tapson V, Frost A.
Chest. 2019 Nov 16. pii: S0012-3692(19)34214-X. doi: 10.1016/j.chest.2019.10.043. [Epub ahead of print]
PMID: 31738929 Free Article
Select item 31734755
Rato J, Sousa A, Cordeiro S, Mendes M, Anjos R.
Int J Cardiol. 2019 Nov 16. pii: S0167-5273(19)33138-9. doi: 10.1016/j.ijcard.2019.11.116. [Epub ahead of print]
PMID: 31785955
Select item 31732763
Santilli RA, Grego E, Battaia S, Gianella P, Tursi M, Di Girolamo N, Biasato I, Perego M.
J Am Vet Med Assoc. 2019 Nov 15;255(10):1150-1160. doi: 10.2460/javma.255.10.1150.
PMID: 31687895
Select item 31730717
Trusty PM, Wei ZA, Rychik J, Graham A, Russo PA, Surrey LF, Goldberg DJ, Yoganathan AP, Fogel MA.
Ann Thorac Surg. 2019 Nov 14. pii: S0003-4975(19)31696-0. doi: 10.1016/j.athoracsur.2019.09.070. [Epub ahead of print]
PMID: 31734244
Select item 31743221
Zentner D, Celermajer DS, Gentles T, d’Udekem Y, Ayer J, Blue GM, Bridgman C, Burchill L, Cheung M, Cordina R, Culnane E, Davis A, du Plessis K, Eagleson K, Finucane K, Frank B, Greenway S, Grigg L, Hardikar W, Hornung T, Hynson J, Iyengar AJ, James P, Justo R, Kalman J, Kasparian N, Le B, Marshall K, Mathew J, McGiffin D, McGuire M, Monagle P, Moore B, Neilsen J, O’Connor B, O’Donnell C, Pflaumer A, Rice K, Sholler G, Skinner JR, Sood S, Ward J, Weintraub R, Wilson T, Wilson W, Winlaw D, Wood A.
Heart Lung Circ. 2019 Nov 14. pii: S1443-9506(19)31458-1. doi: 10.1016/j.hlc.2019.09.010. [Epub ahead of print]
PMID: 31735685 Free Article
Select item 31763440
Leslie CE, Schofield K, Vannatta K, Jackson JL.
Eur J Cardiovasc Nurs. 2019 Nov 13:1474515119885858. doi: 10.1177/1474515119885858. [Epub ahead of print]
PMID: 31722548
Select item 31735919
Téllez L, Rodríguez de Santiago E, Minguez B, Payance A, Clemente A, Baiges A, Morales-Arraez D, La Mura V, Llop E, Garrido E, Garrido-Lestache E, Tasayco S, Bruno O, Prieto R, Montserrat S, Pons M, Olavarría A, Dos L, Valla D, Jesús Del Cerro M, Bañares R, García-Pagán JC, Rautou PE, Albillos A; VALDIG an EASL consortium.
J Hepatol. 2019 Nov 11. pii: S0168-8278(19)30668-3. doi: 10.1016/j.jhep.2019.10.027. [Epub ahead of print]
PMID: 31726116
Select item 31711070
Ehrler M, Latal B, Polentarutti S, von Rhein M, Held L, Wehrle FM.
Pediatr Res. 2019 Nov 11. doi: 10.1038/s41390-019-0667-2. [Epub ahead of print]
PMID: 31711070
Select item 31712678
Córdova-Palomera A, Priest JR.
Sci Rep. 2019 Nov 11;9(1):16515. doi: 10.1038/s41598-019-52969-x.
PMID: 31712678 Free PMC Article
Select item 31712631
Lee CB, Goubergrits L, Fernandes JF, Nordmeyer S, Knosalla C, Berger F, Falk V, Kuehne T, Kelm M.
Sci Rep. 2019 Nov 11;9(1):16407. doi: 10.1038/s41598-019-52909-9.
PMID: 31712631 Free PMC Article
Select item 31082074
McHugh KE, Pasquali SK, Mahle WT.
Ann Thorac Surg. 2019 Nov 7. pii: S0003-4975(19)31628-5. doi: 10.1016/j.athoracsur.2019.09.054. [Epub ahead of print] No abstract available.
PMID: 31706876
Select item 31696653
Howell HB, Zaccario M, Kazmi SH, Desai P, Sklamberg FE, Mally P.
Curr Probl Pediatr Adolesc Health Care. 2019 Nov 7:100685. doi: 10.1016/j.cppeds.2019.100685. [Epub ahead of print]
PMID: 31708366
Select item 31788459
Kari FA, Bohnens H, Bierbach B, Bacha EA, Stiller B, Bauer U.
Ann Thorac Surg. 2019 Nov 9. pii: S0003-4975(19)31682-0. doi: 10.1016/j.athoracsur.2019.09.059. [Epub ahead of print]
PMID: 31715151
Select item 31705822
28 .Update on stem cell technologies in congenital heart disease.
Brown MA, Rajamarthandan S, Francis B, O’Leary-Kelly MK, Sinha P.
J Card Surg. 2019 Nov 9. doi: 10.1111/jocs.14312. [Epub ahead of print] Review.
PMID: 31705822
Select item 31715418
Rodrigues JCL, Jaring MFR, Werndle MC, Mitrousi K, Lyen SM, Nightingale AK, Hamilton MCK, Curtis SL, Manghat NE, Paton JFR, Hart EC.
J Cardiovasc Magn Reson. 2019 Nov 7;21(1):68. doi: 10.1186/s12968-019-0578-8.
PMID: 31703697 Free PMC Article
Select item 31701594
Givertz MM, DeFilippis EM, Landzberg MJ, Pinney SP, Woods RK, Valente AM.
J Am Coll Cardiol. 2019 Nov 5;74(18):2295-2312. doi: 10.1016/j.jacc.2019.09.004. Review.
PMID: 31672187
Select item 31657270
Koop AC, Bossers GPL, Ploegstra MJ, Hagdorn QAJ, Berger RMF, Silljé HHW, Bartelds B.
J Am Heart Assoc. 2019 Nov 5;8(21):e012086. doi: 10.1161/JAHA.119.012086. Epub 2019 Oct 28.
PMID: 31657265 Free Article
Select item 31656122
Venkatesh P, Evans AT, Maw AM, Pashun RA, Patel A, Kim L, Feldman D, Minutello R, Wong SC, Stribling JC, LaPar D, Holzer R, Ginns J, Bacha E, Singh HS.
J Am Heart Assoc. 2019 Nov 5;8(21):e012932. doi: 10.1161/JAHA.119.012932. Epub 2019 Oct 23.
PMID: 31642369 Free Article
Select item 31619105
Dao DT, Kamran A, Wilson JM, Sheils CA, Kharasch VS, Mullen MP, Rice-Townsend SE, Zalieckas JM, Morash D, Studley M, Staffa SJ, Zurakowski D, Becker RE, Smithers CJ, Buchmiller TL.
J Pediatr. 2019 Nov 5. pii: S0022-3476(19)31219-3. doi: 10.1016/j.jpeds.2019.09.053. [Epub ahead of print]
PMID: 31704054
Select item 31688674
Burstein DS, Menachem JN, Opotowsky AR.
Heart Fail Rev. 2019 Nov 4. doi: 10.1007/s10741-019-09867-1. [Epub ahead of print] Review.
PMID: 31686282
Select item 31781201
Udholm S, Udholm L, Nyboe C, Kesmodel US, Hjortdal VE.
Open Heart. 2019 Nov 2;6(2):e001148. doi: 10.1136/openhrt-2019-001148. eCollection 2019.
PMID: 31798916 Free PMC Article
Select item 31271655
Valente AM, Landzberg MJ, Gauvreau K, Egidy-Assenza G, Barker N, Partington S, Morgan RB, Harmon AJ, Hickey K, Mullen MP, Carabuena JM, O’Gara P, Economy KE; STORCC Investigators.
Am Heart J. 2019 Nov;217:112-120. doi: 10.1016/j.ahj.2019.07.015. Epub 2019 Aug 9.
PMID: 31520896
Select item 31493728
Alsaied T, Possner M, Lubert AM, Trout AT, Szugye C, Palermo JJ, Lorts A, Goldstein BH, Veldtman GR, Anwar N, Dillman JR.
Am J Cardiol. 2019 Nov 1;124(9):1454-1459. doi: 10.1016/j.amjcard.2019.07.052. Epub 2019 Aug 7.
PMID: 31474329
Select item 31321831
Kim HJ, Jae SY, Choo J, Yoon JK, Kim SH, Königstein K, Schmidt-Trucksäss A, Franklin BA.
Am J Hum Biol. 2019 Nov;31(6):e23297. doi: 10.1002/ajhb.23297. Epub 2019 Jul 18.
PMID: 31321831
Select item 31064194
Oikonomou E, Lazaros G, Tsalamandris S, Vogiatzi G, Christoforatou E, Papakonstantinou M, Goliopoulou A, Tousouli M, Chasikidis C, Tousoulis D.
Angiology. 2019 Nov;70(10):969-977. doi: 10.1177/0003319719848172. Epub 2019 May 7.
PMID: 31064194
Select item 31400339
Egbe AC, Connolly HM, Miranda WR, Dearani JA, Schaff HV.
Ann Thorac Surg. 2019 Nov;108(5):1410-1415. doi: 10.1016/j.athoracsur.2019.05.068. Epub 2019 Jul 16.
PMID: 31323213
Select item 31299232
Bokma JP, Daily JA, Kovacs AH, Oechslin EN, Baumgartner H, Khairy P, Mulder BJM, Veldtman GR.
Cardiol Young. 2019 Nov;29(11):1356-1360. doi: 10.1017/S1047951119002063. Epub 2019 Sep 10.
PMID: 31502529
Select item 31489832
Willems R, de Hosson M, De Backer J, Annemans L.
Cardiol Young. 2019 Nov;29(11):1368-1374. doi: 10.1017/S1047951119002245. Epub 2019 Sep 6.
PMID: 31489832
Select item 30983081
Srivastava PK, Vyas N, Jones J, Wong TC, Holliman K, Small AJ, Rao RR, Dowling EP, Finn JP, Duckwiler GR, Reardon LC, Aboulhosn JA, Ascher SB, Hogeling M, Lluri G, Yang EH.
Circ Heart Fail. 2019 Nov;12(11):e006561. doi: 10.1161/CIRCHEARTFAILURE.119.006561. Epub 2019 Oct 29. No abstract available.
PMID: 31658832 Free Article
Select item 31677063
Kayvanpour E, Sedaghat-Hamedani F, Gi WT, Tugrul OF, Amr A, Haas J, Zhu F, Ehlermann P, Uhlmann L, Katus HA, Meder B.
Clin Res Cardiol. 2019 Nov;108(11):1297-1308. doi: 10.1007/s00392-019-01465-3. Epub 2019 Apr 12.
PMID: 30980206
Select item 31419027
Chen YC, Weng KP, Chien KJ, Chen BH, Hsieh KS, Tai IH, Huang SH, Peng HH, Huang JS, Wu MT.
Crit Care Med. 2019 Nov;82(11):856-860. doi: 10.1097/JCMA.0000000000000185.
PMID: 31693533
Select item 31686645
Burzo ML, De Matteis G, Nicolazzi MA, Fedele E, Della Polla DA, Pennestrì F, Favuzzi AMR.
Echocardiography. 2019 Nov;36(11):2122-2125. doi: 10.1111/echo.14497. Epub 2019 Oct 1.
PMID: 31573705
Select item 30957859
- Heart failure risk predictions in adult patients with congenital heart disease: a systematic review.
Wang F, Harel-Sterling L, Cohen S, Liu A, Brophy JM, Paradis G, Marelli AJ.
Heart. 2019 Nov;105(21):1661-1669. doi: 10.1136/heartjnl-2019-314977. Epub 2019 Jul 26. Review.
PMID: 31350277
Select item 31292191
Crossland DS, Jansen K, Parry G, Harper A, Perri G, Davidson A, De Rita F, Hermuzi A, Nassar M, Seller N, MacGowan GA, Hasan A, O’Sullivan JJ, Coats L.
Heart. 2019 Nov;105(22):1741-1747. doi: 10.1136/heartjnl-2019-314711. Epub 2019 Jul 5.
PMID: 31278142 Free PMC Article
Select item 31273028
Buber J, Shafer K.
Heart. 2019 Nov;105(21):1670-1679. doi: 10.1136/heartjnl-2018-313928. Epub 2019 Jul 4. No abstract available.
PMID: 31273028
Select item 31129614
Cauldwell M, Steer PJ, Curtis SL, Mohan A, Dockree S, Mackillop L, Parry HM, Oliver J, Sterrenberg M, Wallace S, Malin G, Partridge G, Freeman LJ, Bolger AP, Siddiqui F, Wilson D, Simpson M, Walker N, Hodson K, Thomas K, Bredaki F, Mercaldi R, Walker F, Johnson MR.
Heart. 2019 Nov;105(22):1725-1731. doi: 10.1136/heartjnl-2019-314817. Epub 2019 May 25.
PMID: 31129614 Free Article
Select item 31069588
Rigatelli G, Zuin M, Adami A, Aggio S, Lanza D, d’Elia K, Braggion G, Russo M, Mazza A, Roncon L.
Int J Cardiovasc Imaging. 2019 Nov;35(11):2049-2056. doi: 10.1007/s10554-019-01666-x. Epub 2019 Jul 19.
PMID: 31325066
Select item 31203534
Elzein FE, Alsherbeeni N, Alnajashi K, Alsufyani E, Akhtar MY, Albalawi R, Albarrag AM, Kaabia N, Mehdi S, Alzahrani A, Raoult D.
Int J Infect Dis. 2019 Nov;88:21-26. doi: 10.1016/j.ijid.2019.07.035. Epub 2019 Aug 2.
PMID: 31382048 Free Article
Select item 31361302
Kheradvar A, Rickers C, Morisawa D, Kim M, Hong GR, Pedrizzetti G.
J Cardiol. 2019 Nov;74(5):403-411. doi: 10.1016/j.jjcc.2019.05.005. Epub 2019 Jun 26. Review.
PMID: 31255458
Select item 31688514
Coyne I, Sheehan A, Heery E, While AE.
J Clin Nurs. 2019 Nov;28(21-22):4062-4076. doi: 10.1111/jocn.15006. Epub 2019 Aug 26.
PMID: 31327174
Select item 31723395
Rawala MS, Ahmed AS, Rizvi SB.
J Community Hosp Intern Med Perspect. 2019 Nov 1;9(5):446-448. doi: 10.1080/20009666.2019.1655625. eCollection 2019.
PMID: 31723395 Free PMC Article
Select item 31738213
Ludmir J, Steiner JM, Wong HN, Kloosterboer A, Leong J, Aslakson RA; AAHPM Research Committee Writing Group.
J Pain Symptom Manage. 2019 Nov;58(5):891-898. doi: 10.1016/j.jpainsymman.2019.07.025. Epub 2019 Aug 9.
PMID: 31404639
Select item 31655705
Ludmir J, Steiner JM, Wong HN, Kloosterboer A, Leong J, Aslakson RA; AAHPM Research Committee Writing Group.
J Pain Symptom Manage. 2019 Nov;58(5):891-898. doi: 10.1016/j.jpainsymman.2019.07.025. Epub 2019 Aug 9.
PMID: 31404639
Select item 31655705
Ye J, Chen JY, Xu N, Wu B, Wang ZP, Xu HY, Ma JQ.
Medicine (Baltimore). 2019 Nov;98(47):e18109. doi: 10.1097/MD.0000000000018109.
PMID: 31764849 Free Article
Select item 31702616
Martin SR, Edwards A.
Obstet Gynecol. 2019 Nov;134(5):974-987. doi: 10.1097/AOG.0000000000003549.
PMID: 31599832
Select item 31532867
Seferian A, Jaïs X, Savale L, Jevnikar M, Ghigna MR, Weatherald J, Assoun S, Fadel E, Simonneau G, Sitbon O, Humbert M, Montani D.
Respir Med Res. 2019 Nov;76:48-53. doi: 10.1016/j.resmer.2019.06.002. Epub 2019 Jul 9.
PMID: 31557688
Select item 31560988
Radin M, Schreiber K, Cuadrado MJ, Cecchi I, Andreoli L, Franceschini F, Caleiro T, Andrade D, Gibbone E, Khamashta M, Buyon J, Izmirly P, Aguirre MA, Benedetto C, Roccatello D, Marozio L, Sciascia S.
Rheumatology (Oxford). 2019 Nov 1;58(11):2000-2008. doi: 10.1093/rheumatology/kez141.
PMID: 31079145
Select item 31385648
Oberhoffer FS, Abdul-Khaliq H, Jung AM, Rohrer TR, Abd El Rahman M.
Clin Res Cardiol. 2019 Nov 30. doi: 10.1007/s00392-019-01579-8. [Epub ahead of print]
PMID: 31786629
Select item 31735772
Noessler N, Schweintzger S, Koestenberger M, Kurath-Koller S.
Klin Padiatr. 2019 Nov 26. doi: 10.1055/a-1047-0503. [Epub ahead of print] No abstract available.
PMID: 31770781
Select item 31771606
- Heart failure biomarker levels correlate with invasive haemodynamics in pulmonary valve replacement.
Zegelbone PM, Ringel RE, Coulson JD, Nies MK, Stabler ME, Brown JR, Everett AD.
Cardiol Young. 2019 Nov 27:1-5. doi: 10.1017/S1047951119002737. [Epub ahead of print]
PMID: 31771681
Spiekerkoetter E, Goncharova EA, Guignabert C, Stenmark K, Kwapiszewska G, Rabinovitch M, Voelkel N, Bogaard HJ, Graham B, Pullamsetti SS, Kuebler WM.
Pulm Circ. 2019 Nov 20;9(4):2045894019889775. doi: 10.1177/2045894019889775. eCollection 2019 Oct-Dec.
PMID: 31798835 Free PMC Article
Select item 31739742
Egbe AC, Bonnichsen C, Reddy YNV, Anderson JH, Borlaug BA.
J Am Heart Assoc. 2019 Nov 19;8(22):e014148. doi: 10.1161/JAHA.119.014148. Epub 2019 Nov 8.
PMID: 31701796 Free Article
Select item 31742886
Huang S, Pu T, Wei W, Xu R, Wu Y.
J Gene Med. 2019 Nov 19:e3146. doi: 10.1002/jgm.3146. [Epub ahead of print]
PMID: 31742804
Select item 31742787
Callaghan FM, Burkhardt B, Geiger J, Valsangiacomo Buechel ER, Kellenberger CJ.
Magn Reson Med. 2019 Nov 19. doi: 10.1002/mrm.28085. [Epub ahead of print]
PMID: 31742787
Select item 31745583
Gewillig M, Brown SC, van de Bruaene A, Rychik J.
Acta Paediatr. 2019 Nov 18. doi: 10.1111/apa.15098. [Epub ahead of print] Review.
PMID: 31737940
Select item 31761401
Vermaut A, De Meester P, Troost E, Roggen L, Goossens E, Moons P, Rega F, Meyns B, Gewillig M, Budts W, Van De Bruaene A.
Int J Cardiol. 2019 Nov 18. pii: S0167-5273(19)34712-6. doi: 10.1016/j.ijcard.2019.10.031. [Epub ahead of print]
PMID: 31761401
Select item 31812566
Cantinotti M, Giordano R, Marchese P, Franchi E, Viacava C, Pak V, Murzi B, Arcieri L, Poli V, Federici D, Koestenberger M, Assanta N.
J Cardiothorac Vasc Anesth. 2019 Nov 18. pii: S1053-0770(19)31156-5. doi: 10.1053/j.jvca.2019.11.009. [Epub ahead of print]
PMID: 31812566
Select item 31741130
Goldberg DJ, Zak V, Goldstein BH, Schumacher KR, Rhodes J, Penny DJ, Petit CJ, Ginde S, Menon SC, Kim SH, Kim GB, Nowlen TT, DiMaria MV, Frischhertz BP, Wagner JB, McHugh KE, McCrindle BW, Shillingford AJ, Sabati AA, Yetman AT, John AS, Richmond ME, Files MD, Payne RM, Mackie AS, Davis CK, Shahanavaz S, Hill KD, Garg R, Jacobs JP, Hamstra MS, Woyciechowski S, Rathge KA, McBride MG, Frommelt PC, Russell MW, Urbina EM, Yeager JL, Pemberton VL, Stylianou MP, Pearson GD, Paridon SM; Pediatric Heart Network Investigators.
Circulation. 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044352. [Epub ahead of print]
PMID: 31736357
Select item 31736331
Rato J, Sousa A, Cordeiro S, Mendes M, Anjos R.
Int J Cardiol. 2019 Nov 16. pii: S0167-5273(19)33138-9. doi: 10.1016/j.ijcard.2019.11.116. [Epub ahead of print]
PMID: 31785955
Select item 31734750
Rato J, Ataíde R, Teixeira A.
Cardiol Young. 2019 Nov 15:1-3. doi: 10.1017/S1047951119002579. [Epub ahead of print]
PMID: 31729309
Select item 30684297
Komori M, Hoashi T, Shimada M, Kitano M, Ohuchi H, Kurosaki K, Ichikawa H.
Ann Thorac Surg. 2019 Nov 13. pii: S0003-4975(19)31690-X. doi: 10.1016/j.athoracsur.2019.09.064. [Epub ahead of print]
PMID: 31733188
Select item 31798515
Villemain O, Baranger J, Friedberg MK, Papadacci C, Dizeux A, Messas E, Tanter M, Pernot M, Mertens L.
JACC Cardiovasc Imaging. 2019 Nov 11. pii: S1936-878X(19)30943-X. doi: 10.1016/j.jcmg.2019.09.019. [Epub ahead of print] Review.
PMID: 31734211
Select item 31629745
Zhao J, Si MS, Wang X, Chen S, Yan Q, Chen J.
J Card Surg. 2019 Nov 6. doi: 10.1111/jocs.14322. [Epub ahead of print]
PMID: 31692091
Select item 31694058
Koski TK, Suominen PK, Raissadati A, Knihtilä HM, Ojala TH, Salminen JT.
Acta Anaesthesiol Scand. 2019 Nov;63(10):1384-1389. doi: 10.1111/aas.13431. Epub 2019 Jul 16.
PMID: 31271655
Select item 30799635
Ramanan S, Sasikumar N, Manohar K, Ramani SS, Kumar RS, Agarwal R, Subramanyam R, Cherian KM.
Asian Cardiovasc Thorac Ann. 2019 Nov;27(9):731-737. doi: 10.1177/0218492319882870. Epub 2019 Oct 9. No abstract available.
PMID: 31594378
Select item 31288550
Correia-Costa A, Granja S.
Cardiol Young. 2019 Nov;29(11):1412-1413. doi: 10.1017/S104795111900221X. Epub 2019 Sep 24. No abstract available.
PMID: 31549603
Select item 31522698
81.
ACHD Electrophysiology Featured Articles
Congenital and Pediatric Cardiac EP Review for October-December 2019
Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease.
Yin Y, Dimopoulos K, Shimada E, Lascelles K, Griffiths S, Wong T, Gatzoulis MA, Babu-Narayan SV, Li W.
J Am Heart Assoc. 2019 Nov 5;8(21):e012744. doi: 10.1161/JAHA.119.012744. Epub 2019 Oct 28. Erratum in: J Am Heart Assoc. 2019 Dec 17;8(24):e014507.
PMID: 31657270
Take Home Points:
- Cardiac resynchronization therapy (CRT) appears to provide early and sustained late positive impact on measures related to heart failure in carefully selected patients with adult congenital heart disease (ACHD).
- While findings similar to conventional CRT benefits in ischemic/non-ischemic cardiomyopathy can be achieved in ACHD patients with systemic morphologic LV’s, the same does not appear to be true in ACHD with systemic morphologic RV’s.
Comment from Dr. Philip Chang (Gainesville, FL), section editor of Congenital Electrophysiology Journal Watch: This study by Yin et al retrospectively reviewed outcomes in ACHD patients referred for CRT at a single center between 2004-2017. Factors considered in the application of CRT included reduced LVEF or RV fractional area change (FAC), NYHA functional class, QRS duration, and single-site ventricular pacing burden. General demographic, cardiac, cardiac surgical, and clinical data; device implant-related variables; cardiothoracic ratio on x-ray, echo and surface ECG data; and follow-up assessment and outcomes variables were collected by chart review. The authors defined bundle branch block as QRS duration ≥120 ms and positive CRT response as ≥5% increase in LVEF or RVFAC following CRT initiation.
A total of 54 patients with comprehensive data sets and follow-up duration were included for analysis. Patient age varied widely (18-73 years, mean 46 years) and most patients were male (74%). Mean follow-up duration from CRT was 5.7 years, with early and late follow-up arbitrarily delineated as mean 1.8±0.8 years and 4.7±0.8 years, respectively, after CRT device implant. A majority of patients had systemic morphologic LV’s (39 patients, 72%) comprised of several forms of CHD while the remaining patients with systemic morphologic RV’s had either D- or L-TGA variants (the majority being L-TGA, 13/15 patients). Of the entire cohort, 33/54 patients met a primary ventricular pacing indication prior to CRT, either due to high-grade AV block or following AV node ablation. Over half of the cohort had preexisting cardiac implantable devices (21 pacemakers, 10 ICD’s). In total, 46/54 patients were implanted with a CRT-D device with the remaining 8 patients implanted with CRT-P systems. The vast majority of patients received transvenous systems only (52/54); 2 patients underwent hybrid transvenous and surgical epicardial lead placement. 19% of patients experienced complications including infection (5 patients, 9%) and lead dislodgement (3 patients, 6%).
Overall, a positive response to CRT was noted in 65% of the entire cohort. This was primarily driven by favorable early and late responses in ACHD patients with systemic LV’s. Figure 1 from the manuscript depicts the changes in CT ratio (B), QRS duration (C), NYHA class (D), systemic LVEF (E), and systemic RVFAC (F) over the time points of the analysis. In general, while there was overall improvement across all measures of CRT response at early follow-up, only NYHA class improvement and LV functional measures were sustained at late follow-up. Among systemic LV recipients, most (74%) had improvement in LVEF that was sustained out to nearly 2 years following CRT. Systemic LV patients with history of LVOT obstructive CHD showed the highest response (15/17 patients, 88%). Only 40% of systemic RV patients exhibited early-term positive response. All-cause mortality occurred in 20% of patients during follow-up. Multi-variate analysis showed QRS duration to be the only independent predictor of CRT response irrespective of permanent pacing or QRS morphology. Kaplan Meier analysis shows somewhat contrary data with systemic RV patients actually exhibiting a longer duration of freedom from death or transplant compared to systemic LV patients following CRT. No comparison to non-CRT cohorts was made.
Though there are substantial limitations to this study, it provides some data and insights into longer-term outcomes in ACHD patients receiving CRT, which is still insufficiently understood given low cohort sizes across multiple studies. The rather high complication rate following CRT device implants reported in this study likely reflects the contributions of device-related re-interventions in patients with pre-existing cardiac implantable devices and other comorbidities, which are recognized to increase the risk of infections, as well as the technical challenges of CRT implant in CHD, even among patients with systemic LV’s. From studies and trials on CRT in ischemic and non-ischemic cardiomyopathy in baseline structurally normal hearts, positive CRT response is linked to LBBB-type wide QRS, wider QRS duration (paced or non-paced), and defined evidence of LV dyssynchrony. Favorable response to CRT can generally be expected when application of biventricular or even multi-site ventricular pacing in these scenarios effectively targets the area of latest electrical activation. Positive CRT response has also been associated with “ideal” target vessel lead implantation (usually lateral/free wall LV in a basilar/mid-LV location) as well as very high percentage biventricular pacing (>98%). This study failed to mention consistent achievement of these variables, which certainly could affect CRT response. With that said, the findings from this study are consistent with the notion that systemic LV ACHD appears to exhibit a similar response to CRT compared to conventional ischemic and nonischemic cardiomyopathy substrates with similar heart failure indices and variables. The lower CRT response in systemic RV’s may reflect implant variables and lead placement along with the unique morphologic, structural, contractile, and electrophysiologic (i.e.. single RBB vs. left anterior and posterior fascicles in LBB) differences between RV’s and LV’s. Ventricular inter-dependence was not mentioned in this study, which could potentially be of impact in patients where the subpulmonary ventricle also exhibits significant dysfunction (as in the case of tetralogy of Fallot patients with biventricular dysfunction). Wider baseline QRS as an independent predictor of positive CRT response can likely be understood by viewing wider QRS duration as reflecting greater ventricular electrical delay and dyssynchrony, which should stand to improve if the region of greatest delay is properly resynchronized. As the authors mentioned, there remains a lack of solid, consensus guidelines regarding patient selection and consistent clinical variables to guide CRT implant among the heterogeneous ACHD population.
CHD EP Nov 2019
Lévesque V, Laplante L, Shohoudi A, Apers S, Kovacs AH, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Brouillette J, Casteigt B, Moons P, Khairy P; APPROACH-IS consortium and the International Society for Adult Congenital Heart Disease (ISACHD).
Heart Rhythm. 2019 Nov 29. pii: S1547-5271(19)31089-6. doi: 10.1016/j.hrthm.2019.11.026. [Epub ahead of print]
PMID: 31790832
Select item 31782834
Rigatelli G, Zuin M, Roncon L.
J Cardiovasc Med (Hagerstown). 2019 Nov 26. doi: 10.2459/JCM.0000000000000897. [Epub ahead of print]
PMID: 31789712
Select item 31769098
Westaby JD, Cooper STE, Edwards KA, Anderson RH, Sheppard MN.
Clin Anat. 2019 Nov 25. doi: 10.1002/ca.23531. [Epub ahead of print]
PMID: 31769098
Select item 31767648
Chubb H, Motonaga KS.
Heart Fail Rev. 2019 Nov 21. doi: 10.1007/s10741-019-09886-y. [Epub ahead of print] Review.
PMID: 31754907
Select item 31785958
Anderson H, Dearani J, Qureshi MY, Holst K, O’Leary P, Cannon B, Wackel P.
Pediatr Cardiol. 2019 Nov 19. doi: 10.1007/s00246-019-02242-9. [Epub ahead of print]
PMID: 31745583
Select item 31743362
Hagdorn QAJ, Vos JDL, Beurskens NEG, Gorter TM, Meyer SL, van Melle JP, Berger RMF, Willems TP.
Int J Cardiol. 2019 Nov 15;295:1-6. doi: 10.1016/j.ijcard.2019.07.097. Epub 2019 Aug 1.
PMID: 31402156 Free Article
Select item 31731673
Hock J, Wheeler M, Singh T, Ha LD, Hadley D, Froelicher V.
Clin J Sport Med. 2019 Nov 14. doi: 10.1097/JSM.0000000000000766. [Epub ahead of print]
PMID: 31743221
Select item 31735685
Egbe AC, Najam M, Banala K, Vojjini R, Osman K, Abhishek D.
Int J Cardiol Heart Vasc. 2019 Nov 14;26:100426. doi: 10.1016/j.ijcha.2019.100426. eCollection 2020 Feb.
PMID: 31763440 Free PMC Article
Select item 31728571
Combes N, Bartoletti S, Hascoët S, Vahdat O, Heitz F, Waldmann V.
Europace. 2019 Nov 12. pii: euz310. doi: 10.1093/europace/euz310. [Epub ahead of print] No abstract available.
PMID: 31713633
Select item 31735417
Kovacs B, Reek S, Saguner AM, Krasniqi N, Eriksson U, Duru F.
Swiss Med Wkly. 2019 Nov 10;149:w20136. doi: 10.4414/smw.2019.20136. eCollection 2019 Nov 4.
PMID: 31707723 Free Article
Select item 31715151
Yin Y, Dimopoulos K, Shimada E, Lascelles K, Griffiths S, Wong T, Gatzoulis MA, Babu-Narayan SV, Li W.
J Am Heart Assoc. 2019 Nov 5;8(21):e012744. doi: 10.1161/JAHA.119.012744. Epub 2019 Oct 28. Erratum in: J Am Heart Assoc. 2019 Dec 17;8(24):e014507.
PMID: 31657270 Free Article
Select item 31657265
Morgan RW, Topjian AA, Wang Y, Atkin NJ, Kilbaugh TJ, McGowan FX, Berg RA, Mercer-Rosa L, Sutton RM, Himebauch AS.
Pediatr Crit Care Med. 2019 Nov 5. doi: 10.1097/PCC.0000000000002187. [Epub ahead of print]
PMID: 31688674
Select item 31687920
Miyazaki A, Yoshimura SI, Matsutani H, Miyake M, Negishi J, Yamanaka K, Yamada O, Doi H, Ohuchi H.
Cardiol Young. 2019 Nov;29(11):1375-1379. doi: 10.1017/S1047951119002257. Epub 2019 Sep 11.
PMID: 31507257
Select item 31502529
Silva JNA, Van Hare GF.
Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e008019. doi: 10.1161/CIRCEP.119.008019. Epub 2019 Nov 14. No abstract available.
PMID: 31722542
Select item 31722541
Houck CA, Chandler SF, Bogers AJJC, Triedman JK, Walsh EP, de Groot NMS, Abrams DJ.
Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007663. doi: 10.1161/CIRCEP.119.007663. Epub 2019 Nov 14.
PMID: 31722541
Select item 31638415
Kiuchi MG, Chen S, Carnagarin R, Matthews VB, Schlaich MP.
Europace. 2019 Nov 1;21(11):1755-1756. doi: 10.1093/europace/euz251. No abstract available.
PMID: 31603504
Select item 31424500
Rudbeck-Resdal J, Christiansen MK, Johansen JB, Nielsen JC, Bundgaard H, Jensen HK.
Europace. 2019 Nov 1;21(11):1710-1716. doi: 10.1093/europace/euz206.
PMID: 31424500 Free PMC Article
Select item 31697272
Kella DK, Yasin OZ, Isath AM, McLeod CJ, Canon B, Asirvatham SJ, Wackel PL.
Heart Rhythm. 2019 Nov;16(11):1621-1628. doi: 10.1016/j.hrthm.2019.04.045. Epub 2019 Apr 29.
PMID: 31048063
Select item 31325066
Waldmann V, Ladouceur M, Bougouin W, Combes N, Maltret A, Dumas F, Iserin L, Cariou A, Marijon E, Jouven X.
JACC Clin Electrophysiol. 2019 Nov;5(11):1355-1356. doi: 10.1016/j.jacep.2019.07.017. No abstract available.
PMID: 31753444
Select item 31770213
Kumar V, Kumar G, Tiwari N, Joshi S, Sharma V, Ramamurthy R.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):709-714. doi: 10.1177/2150135119876600.
PMID: 31701840
Select item 31701839
Yasuhara J, Kuno T, Taki M, Toda K, Kumamoto T, Kojima T, Shimizu H, Yoshiba S, Kobayashi T, Sumitomo N.
Int Heart J. 2019 Nov 30;60(6):1358-1365. doi: 10.1536/ihj.19-099. Epub 2019 Nov 15.
PMID: 31735772 Free Article
Select item 31786619
Lim TR, Rangaswami AA, Dubin AM, Kapphahn KI, Sakarovitch C, Long J, Motonaga KS, Trela T, Ceresnak SR.
J Pediatr. 2019 Nov 21. pii: S0022-3476(19)31341-1. doi: 10.1016/j.jpeds.2019.10.018. [Epub ahead of print]
PMID: 31761428
Select item 31766503
Zhang Y, Li XM, Jiang H, Ge HY, Liu HJ, Li MT.
Zhonghua Xin Xue Guan Bing Za Zhi. 2019 Nov 24;47(11):901-906. doi: 10.3760/cma.j.issn.0253-3758.2019.11.009. Chinese.
PMID: 31744280
Select item 31760507
El-Battrawy I, Roterberg G, Schlentrich K, Liebe V, Lang S, Rudic B, Tülümen E, Zhou X, Borggrefe M, Akin I.
Pediatr Cardiol. 2019 Nov 20. doi: 10.1007/s00246-019-02254-5. [Epub ahead of print]
PMID: 31748893
Rato J, Ataíde R, Martins D, Moldovan O, Cavaco D, Anjos R.
Rev Esp Cardiol (Engl Ed). 2019 Nov 18. pii: S1885-5857(19)30334-2. doi: 10.1016/j.rec.2019.10.007. [Epub ahead of print] English, Spanish. No abstract available.
PMID: 31753771
Select item 31736357
Butera G, Hansen JH, Jones MI.
Catheter Cardiovasc Interv. 2019 Nov 15;94(6):894. doi: 10.1002/ccd.28083. Epub 2019 Jan 25. No abstract available.
PMID: 30684297
Select item 31731876
Hagdorn QAJ, Vos JDL, Beurskens NEG, Gorter TM, Meyer SL, van Melle JP, Berger RMF, Willems TP.
Int J Cardiol. 2019 Nov 15;295:1-6. doi: 10.1016/j.ijcard.2019.07.097. Epub 2019 Aug 1.
PMID: 31402156 Free Article
Select item 31756661
Horigome H, Ishikawa Y, Kokubun N, Yoshinaga M, Sumitomo N, Lin L, Kato Y, Tanabe-Kameda Y, Ohno S, Nagashima M, Horie M.
Ann Noninvasive Electrocardiol. 2019 Nov 14:e12721. doi: 10.1111/anec.12721. [Epub ahead of print]
PMID: 31724784
Select item 31743221
Takeuchi D, Toyohara K, Shoda M, Hagiwara N.
J Cardiovasc Electrophysiol. 2019 Nov 14. doi: 10.1111/jce.14273. [Epub ahead of print]
PMID: 31724792
Select item 31735418
Karikari Y, Abdulkarim M, Li Y, Loomba RS, Zimmerman F, Husayni T.
Pediatr Cardiol. 2019 Nov 13. doi: 10.1007/s00246-019-02237-6. [Epub ahead of print]
PMID: 31722042
Select item 31720744
Combes N, Bartoletti S, Hascoët S, Vahdat O, Heitz F, Waldmann V.
Europace. 2019 Nov 12. pii: euz310. doi: 10.1093/europace/euz310. [Epub ahead of print] No abstract available.
PMID: 31713633
Select item 31732132
Kumthekar RN, Opfermann JD, Mass P, Clark BC, Moak JP, Sherwin ED, Whitman T, Marshall M, Berul CI.
Pacing Clin Electrophysiol. 2019 Nov 12. doi: 10.1111/pace.13843. [Epub ahead of print]
PMID: 31721231
Select item 31720784
34.Catheter ablation of ventricular tachycardia in the pediatric patients: A single-center experience.
Wu J, Chen Y, Ji W, Gu B, Shen J, Fu L, Li F.
Pacing Clin Electrophysiol. 2019 Nov 7. doi: 10.1111/pace.13835. [Epub ahead of print]
PMID: 31701534
Select item 31701166
Yin Y, Dimopoulos K, Shimada E, Lascelles K, Griffiths S, Wong T, Gatzoulis MA, Babu-Narayan SV, Li W.
J Am Heart Assoc. 2019 Nov 5;8(21):e012744. doi: 10.1161/JAHA.119.012744. Epub 2019 Oct 28. Erratum in: J Am Heart Assoc. 2019 Dec 17;8(24):e014507.
PMID: 31657270 Free Article
Select item 31657265
Köşger P, Sevinç Şengül F, Kafalı HC, Uçar B, Ergül Y.
Anatol J Cardiol. 2019 Nov;22(5):272-275. doi: 10.14744/AnatolJCardiol.2019.93707. No abstract available.
PMID: 31674939 Free Article
Select item 31199031
Sharma N, Cortez D, Imundo JR.
Ann Noninvasive Electrocardiol. 2019 Nov;24(6):e12663. doi: 10.1111/anec.12663. Epub 2019 Jun 14.
PMID: 31199031
Select item 31653289
Miyazaki A, Yoshimura SI, Matsutani H, Miyake M, Negishi J, Yamanaka K, Yamada O, Doi H, Ohuchi H.
Cardiol Young. 2019 Nov;29(11):1375-1379. doi: 10.1017/S1047951119002257. Epub 2019 Sep 11.
PMID: 31507257
Select item 31502531
39, Catheter Ablation in Pediatric Congenital Heart Disease: A Modern Perspective.
Silva JNA, Van Hare GF.
Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e008019. doi: 10.1161/CIRCEP.119.008019. Epub 2019 Nov 14. No abstract available.
PMID: 31722542
Select item 31722541
Houck CA, Chandler SF, Bogers AJJC, Triedman JK, Walsh EP, de Groot NMS, Abrams DJ.
Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007663. doi: 10.1161/CIRCEP.119.007663. Epub 2019 Nov 14.
PMID: 31722541
Select item 31638832
Mellor GJ, Panwar P, Lee AK, Steinberg C, Hathaway JA, Bartels K, Christian S, Balaji S, Roberts JD, Simpson CS, Boczek NJ, Tester DJ, Radbill AE, Mok NS, Hamilton RM, Kaufman ES, Eugenio PL, Weiss R, January C, McDaniel GM, Leather RA, Erickson C, Falik S, Behr ER, Wilde AAM, Sanatani S, Ackerman MJ, Van Petegem F, Krahn AD, Laksman Z.
Europace. 2019 Nov 1;21(11):1725-1732. doi: 10.1093/europace/euz215.
PMID: 31408100
Select item 31563034
Ali H, Foresti S, Mariucci E, Bronzetti G, De Ambroggi G, Cappato R.
J Cardiovasc Electrophysiol. 2019 Nov;30(11):2542-2545. doi: 10.1111/jce.14173. Epub 2019 Sep 25. No abstract available.
PMID: 31515886
Select item 31432598
Hoyt WJ Jr, Fish FA, Kannankeril PJ.
J Cardiovasc Electrophysiol. 2019 Nov;30(11):2599-2602. doi: 10.1111/jce.14125. Epub 2019 Aug 23.
PMID: 31432598
Select item 31309848
Kumar V, Kumar G, Tiwari N, Joshi S, Sharma V, Ramamurthy R.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):709-714. doi: 10.1177/2150135119876600.
PMID: 31701840
Select item 31701836
ACHD Interventional Cardiology Featured Articles
Interventional Cardiology Reviews of October- December 2019 Manuscripts
Pulmonary hemorrhage in children with Alagille syndrome undergoing cardiac catheterization.
Adamson GT, Peng LF, Feinstein JA, Yarlagadda VV, Lin A, Wise-Faberowski L, McElhinney DB.
Catheter Cardiovasc Interv. 2019 Oct 4. doi: 10.1002/ccd.28508. [Epub ahead of print]
PMID: 31584246
Select item 31584303
Take Home Points:
- Patients with Alagille syndrome have a significant risk of pulmonary hemorrhage with both diagnostic and interventional cardiac catheterizations.
- A diagnosis of tetralogy of Fallot, higher RV to aorta pressure ratio, and PA angioplasty are associated with an increased risk of pulmonary hemorrhage.
- The exact etiology of this increased risk remains unknown and warrants further investigation.
Commentary from Dr. Ryan Romans (Kansas City, MO), section editor of Congenital Heart Disease Interventions Journal Watch: Children with Alagille syndrome often have hemorrhagic complications during invasive procedures and are also at risk for spontaneous bleeds (particularly intracranial hemorrhage). This is thought to be a result of abnormalities in angiogenesis, hemostasis, and/or platelet function. Some have suggested that the bleeding risk is associated with the severity of congenital cardiovascular phenotype. This bleeding risk contributes significantly to morbidity and mortality in this patient population. The large majority (90%) of children with Alagille syndrome have congenital heart disease. This typically affects the branch pulmonary arteries (PA), though the disease severity is highly variable. It can range from mild branch PA stenosis to severe diffuse PA hypoplasia. Tetralogy of Fallot (TOF) is seen in ~ 15% of children [including TOF with pulmonary atresia and major aortopulmonary collateral arteries (TOF/PA/MAPCAs)]. Patients with Alagille syndrome who have the most severe cardiovascular disease are frequently referred to the cardiac catheterization lab for diagnostic catheterizations to assist in surgical planning or for interventional procedures (pulmonary angioplasty and/or stent implantation). Pulmonary hemorrhage is a known complication of branch PA intervention in general and has anecdotally been seen in higher frequencies in patients with Alagille syndrome.
Adamson et al report on their retrospective single center experience with 30 patients with Alagille syndrome who underwent a total of 87 cardiac catheterizations (median 2 per patient) over an 8 year period (2010-2018). The most common diagnosis was isolated branch PA stenosis/hypoplasia in 15 patients (50%) followed by TOF/PA/MAPCAs in 10 patients (33%), TOF in 4 patients (13%), and pulmonary atresia with an intact ventricular septum (PA/IVS) and MAPCAs in a single patient. Surgical intervention had been performed prior to the cardiac catheterization in 61% of cases. The cardiac catheterizations included branch PA interventions in 37% of the cases and were diagnostic cardiac catheterizations in the remaining 73%. All patients were systemically heparinized with an activated coagulation time maintained above 200 seconds.
Pulmonary hemorrhage occurred in 26/87 cardiac catheterizations (30%) and in 14/30 patients (46%). The majority of these (n=17, 65%) were mild hemorrhage (defined as mechanical ventilation <24 hours, no treatment other than a single packed red blood cell transfusion). There were 4 (15%) moderate hemorrhages (24-72 hours mechanical ventilation or >72 hours noninvasive positive pressure ventilation), and 5 (19%) severe hemorrhages (>72 hours mechanical ventilation, use of inotropic support, ECMO, or death). Only two of the hemorrhages were clearly due to a vessel tear from an intervention, though the source of bleeding was not always able to be identified on review of the medical records. Two hemorrhages were managed with venoarterial ECMO support without any major ECMO complications or deaths. No patients required intravascular closure devices or covered stents to treat the hemorrhage. All 9 moderate and severe hemorrhages occurred in 5 patients with TOF, three of whom had TOF/PA/MAPCAs.
The authors highlight that pulmonary hemorrhage occurred in approximately one third of procedures, including 44% of interventional and 22% of diagnostic cardiac catheterizations (incidence in patients without Alagille syndrome undergoing PA angioplasty 12-14% in two recent studies). Fortunately, the majority of these were mild. Two patient’s required ECMO support but there were no deaths. Higher RV to aorta pressure ratio, intervention on the branch PAs, and a diagnosis of TOF were associated with pulmonary hemorrhage, with severe hemorrhage occurring primarily in patients with TOF/PA/MAPCAs. The authors note that the patient population they care for is not representative of a typical center’s given their expertise in surgical branch pulmonary arterioplasty (~12% of patients with Alagille syndrome have TOF with 1/3 of those TOF/PA/MAPCAs, nearly 50% with TOF and 2/3 of these with TOF/PA/MAPCAs in this cohort). Additionally, they may be less aggressive intervening in the cath lab given their centers preference for surgical intervention when possible and thus may be underestimating the risk of pulmonary hemorrhage.
CHD Interventions Nov 2019
Araszkiewicz A, Bartuś S, Demkow M, Grygier M, Huczek Z, Komar M, Pracoń R, Przewłocki T, Sabiniewicz R, Smolka G, Olszowska M, Wojakowski W.
Kardiol Pol. 2019 Nov 22;77(11):1094-1105. doi: 10.33963/KP.15058. Epub 2019 Nov 13.
PMID: 31723115 Free Article
Select item 31758210
Maschietto N, Baird C, Porras D.
Catheter Cardiovasc Interv. 2019 Nov 19. doi: 10.1002/ccd.28598. [Epub ahead of print]
PMID: 31743550
Select item 31767386
Kitano M, Yazaki S, Sugiyama H, Ohtsuki SI, Tomita H.
Pediatr Cardiol. 2019 Nov 16. doi: 10.1007/s00246-019-02256-3. [Epub ahead of print]
PMID: 31732763
Select item 31729148
Sorensen MW, Bauser-Heaton H, Petit CJ.
Catheter Cardiovasc Interv. 2019 Nov 15. doi: 10.1002/ccd.28597. [Epub ahead of print]
PMID: 31729148
Select item 31730227
Li YF, Xie YM, Chen J, Li BN, Xie ZF, Wang SS, Zhang ZW.
Catheter Cardiovasc Interv. 2019 Nov 12. doi: 10.1002/ccd.28529. [Epub ahead of print]
PMID: 31714687
Select item 31713974
Godart F, Baudelet JB, Soquet J, Onorato E.
Catheter Cardiovasc Interv. 2019 Nov 12. doi: 10.1002/ccd.28587. [Epub ahead of print]
PMID: 31713974
Select item 31768425
Callahan R, Esch JJ, Wang G, Ireland CM, Gauvreau K, Jenkins KJ.
Pediatr Cardiol. 2019 Nov 12. doi: 10.1007/s00246-019-02253-6. [Epub ahead of print]
PMID: 31720783
Select item 31713990
Haughey BS, White SC, Pacheco GS, Fox KA, Seckeler MD.
Pediatr Cardiol. 2019 Nov 8. doi: 10.1007/s00246-019-02247-4. [Epub ahead of print]
PMID: 31705178
Select item 31706876
Serfas JD, Turek J, Haney J, Krasuski RA, Fleming GA.
Catheter Cardiovasc Interv. 2019 Nov 7. doi: 10.1002/ccd.28591. [Epub ahead of print]
PMID: 31696653
Select item 31708366
Nageotte SJ, Lee JW, El-Said HG, Moore JW, Ratnayaka K.
JACC Cardiovasc Interv. 2019 Nov 7. pii: S1936-8798(19)31886-2. doi: 10.1016/j.jcin.2019.08.051. [Epub ahead of print] No abstract available.
PMID: 31734303
Select item 31761487
Evertz R, Houck CA, Ten Cate T, Duijnhouwer AL, Beukema R, Westra S, Vernooy K, de Groot NMS.
Congenit Heart Dis. 2019 Nov 6. doi: 10.1111/chd.12859. [Epub ahead of print]
PMID: 31692272
Select item 31749841
Arya V, Azad S, Radhakrishnan S.
Cardiol Young. 2019 Nov 4:1-4. doi: 10.1017/S1047951119002592. [Epub ahead of print]
PMID: 31679544
Select item 31686282
Patel ND, Justino H, Ing FF.
Catheter Cardiovasc Interv. 2019 Nov 1;94(5):732-737. doi: 10.1002/ccd.28227. Epub 2019 Apr 14.
PMID: 30983081
Select item 31516082
Stephensen SS, Ostenfeld E, Kutty S, Steding-Ehrenborg K, Arheden H, Thilén U, Carlsson M.
Int J Cardiovasc Imaging. 2019 Nov;35(11):2077-2084. doi: 10.1007/s10554-019-01647-0. Epub 2019 Jun 15.
PMID: 31203534 Free PMC Article
Select item 31382048
Harky A, Noshirwani A, Karadakhy O, Ang J.
J Card Surg. 2019 Nov;34(11):1328-1343. doi: 10.1111/jocs.14228. Epub 2019 Aug 26. Review.
PMID: 31449703
Select item 31449693
Kylat RI, Witte MH, Barber BJ, Dori Y, Ghishan FK.
Pediatr Gastroenterol Hepatol Nutr. 2019 Nov;22(6):594-600. doi: 10.5223/pghn.2019.22.6.594. Epub 2019 Nov 7.
PMID: 31777727 Free PMC Article
Select item 31469782
Harrar DB, Salussolia CL, Vittner P, Danehy A, Sen S, Whitehill R, Chao JH, Bernson-Leung ME, Rivkin MJ.
Pediatr Neurol. 2019 Nov;100:42-48. doi: 10.1016/j.pediatrneurol.2019.07.005. Epub 2019 Jul 19.
PMID: 31481331
Select item 31407854
Suntharos P, Worley SE, Liu W, Siperstein M, Prieto LR.
Catheter Cardiovasc Interv. 2019 Nov 28. doi: 10.1002/ccd.28628. [Epub ahead of print]
PMID: 31778024
Select item 31781972
Miranda WR, Connolly HM, Hagler DJ.
JACC Cardiovasc Interv. 2019 Nov 25;12(22):2320-2321. doi: 10.1016/j.jcin.2019.05.036. Epub 2019 Oct 30. No abstract available.
PMID: 31678091
Select item 31768578
Perdreau E, Jalal Z, Walton RD, Naulin J, Magat J, Quesson B, Cochet H, Bernus O, Thambo JB.
Int J Cardiovasc Imaging. 2019 Nov 19. doi: 10.1007/s10554-019-01734-2. [Epub ahead of print] Review.
PMID: 31745743
Select item 31718444
Toizumi M, Do CGT, Motomura H, Do TN, Fukunaga H, Iijima M, Le NN, Nguyen HT, Moriuchi H, Yoshida LM.
Sci Rep. 2019 Nov 19;9(1):17105. doi: 10.1038/s41598-019-52936-6.
PMID: 31745134 Free PMC Article
Select item 31744402
Kitano M, Yazaki S, Sugiyama H, Ohtsuki SI, Tomita H.
Pediatr Cardiol. 2019 Nov 16. doi: 10.1007/s00246-019-02256-3. [Epub ahead of print]
PMID: 31732763
Select item 31522774
Shokr M, Adegbala O, Elmoghrabi A, Saleh M, Ajam M, Ali A, Yassin AS, Ando T, Eperjesiova B, Aly A, Pahuja M, Ashraf S, Abubakar H, Ahmed A, Subahi A, Lieberman R, Afonso L.
Am J Cardiol. 2019 Nov 15;124(10):1601-1607. doi: 10.1016/j.amjcard.2019.08.012. Epub 2019 Aug 22.
PMID: 31522774
Select item 31729175
Li YF, Xie YM, Chen J, Li BN, Xie ZF, Wang SS, Zhang ZW.
Catheter Cardiovasc Interv. 2019 Nov 12. doi: 10.1002/ccd.28529. [Epub ahead of print]
PMID: 31714687
Select item 31713974
Shyu TC, Chuang CM, Tai IH, Chu KH, Fu YC.
JACC Cardiovasc Interv. 2019 Nov 11;12(21):e187-e188. doi: 10.1016/j.jcin.2019.06.051. Epub 2019 Oct 16. No abstract available.
PMID: 31629745
Select item 31564593
Hiremath G, Morgan G, Kenny D, Batlivala SP, Bartakian S.
Catheter Cardiovasc Interv. 2019 Nov 9. doi: 10.1002/ccd.28575. [Epub ahead of print]
PMID: 31705789
Select item 31707901
Haughey BS, White SC, Pacheco GS, Fox KA, Seckeler MD.
Pediatr Cardiol. 2019 Nov 8. doi: 10.1007/s00246-019-02247-4. [Epub ahead of print]
PMID: 31705178
Select item 31697579
Serfas JD, Turek J, Haney J, Krasuski RA, Fleming GA.
Catheter Cardiovasc Interv. 2019 Nov 7. doi: 10.1002/ccd.28591. [Epub ahead of print]
PMID: 31696653
Select item 31698967
O’Byrne ML, Kennedy KF, Jayaram N, Bergersen LJ, Gillespie MJ, Dori Y, Silber JH, Kawut SM, Rome JJ, Glatz AC.
J Am Heart Assoc. 2019 Nov 5;8(21):e013151. doi: 10.1161/JAHA.119.013151. Epub 2019 Oct 17.
PMID: 31619106 Free Article
Select item 31615305
Arya V, Azad S, Radhakrishnan S.
Cardiol Young. 2019 Nov 4:1-4. doi: 10.1017/S1047951119002592. [Epub ahead of print]
PMID: 31679544
Select item 31680140
O’Byrne ML, Millenson ME, Grady CB, Huang J, Bamat NA, Munson DA, Song L, Dori Y, Gillespie MJ, Rome JJ, Glatz AC.
Am Heart J. 2019 Nov;217:121-130. doi: 10.1016/j.ahj.2019.08.009. Epub 2019 Aug 17.
PMID: 31654942
Select item 31520898
Mohakud AR, Pavithran S, Sivakumar K.
Cardiol Young. 2019 Nov;29(11):1397-1399. doi: 10.1017/S1047951119001963. Epub 2019 Sep 10.
PMID: 31500684
Select item 31486350
Hubrechts J, Cools B, Brown SC, Eyskens B, Heying R, Boshoff D, Gewillig M.
Catheter Cardiovasc Interv. 2019 Nov 1;94(5):722-726. doi: 10.1002/ccd.28457. Epub 2019 Aug 21.
PMID: 31433549
Select item 30851076
Karmegaraj B, Prabhu N, Kappanayil M, Kumar RK.
Catheter Cardiovasc Interv. 2019 Nov 1;94(5):727-731. doi: 10.1002/ccd.28174. Epub 2019 Mar 9.
PMID: 30851076
Select item 31722542
Stephensen SS, Ostenfeld E, Kutty S, Steding-Ehrenborg K, Arheden H, Thilén U, Carlsson M.
Int J Cardiovasc Imaging. 2019 Nov;35(11):2077-2084. doi: 10.1007/s10554-019-01647-0. Epub 2019 Jun 15.
PMID: 31203534 Free PMC Article
Select item 31336146
Kim HS, Schechter MA, Manning PB, Eghtesady P, Balzer DT, Shahanavaz S, Rockefeller TA, Abarbanell AM.
J Surg Res. 2019 Nov;243:41-46. doi: 10.1016/j.jss.2019.04.069. Epub 2019 May 30.
PMID: 31154131
Select item 31493880
Lasa JJ, Alali A, Minard CG, Parekh D, Kutty S, Gaies M, Raymond TT, Guerguerian AM, Atkins D, Foglia E, Fink E, Roberts J, Duval-Arnould J, Bembea M, Kleinman M, Gupta P, Sutton R, Sawyer T; American Heart Association’s Get With the Guidelines-Resuscitation Investigators.
Pediatr Crit Care Med. 2019 Nov;20(11):1040-1047. doi: 10.1097/PCC.0000000000002038.
PMID: 31232852
Select item 31355962
Harrar DB, Salussolia CL, Vittner P, Danehy A, Sen S, Whitehill R, Chao JH, Bernson-Leung ME, Rivkin MJ.
Pediatr Neurol. 2019 Nov;100:42-48. doi: 10.1016/j.pediatrneurol.2019.07.005. Epub 2019 Jul 19.
PMID: 31481331
Select item 31483086
ACHD Surgery
CHD Surgery Nov 2019
Rooze S, Namane SA, Beretta X, Vicinanza A, Vens D, Voglet C, Willems A, Goyens P, Biarent D.
Eur J Pediatr. 2019 Nov 28. doi: 10.1007/s00431-019-03505-6. [Epub ahead of print]
PMID: 31781932
Select item 31775637
Zhang X, Wang W, Yan J, Wang Q.
J Card Surg. 2019 Nov 25. doi: 10.1111/jocs.14369. [Epub ahead of print]
PMID: 31765039
Select item 31789884
Lahiri S, Wang Y, Caldarone CA, Morris SA.
Pediatr Cardiol. 2019 Nov 22. doi: 10.1007/s00246-019-02224-x. [Epub ahead of print]
PMID: 31758210
Select item 31755375
Zografos PM, Protopapas EM, Hakim NI, Alexopoulos C, Sarris GE.
World J Pediatr Congenit Heart Surg. 2019 Nov 22:2150135119878703. doi: 10.1177/2150135119878703. [Epub ahead of print]
PMID: 31755375
Select item 31752736
VanderPluym CJ, Cantor RS, Machado D, Boyle G, May L, Griffiths E, Niebler RA, Lorts A, Rossano J, Sutcliffe DL, Lytrivi ID, Buchholz H, Fynn-Thompson F, Hawkins B, Conway J.
ASAIO J. 2019 Nov 20. doi: 10.1097/MAT.0000000000001093. [Epub ahead of print]
PMID: 31789654
Select item 31758944
Gewillig M, Brown SC, van de Bruaene A, Rychik J.
Acta Paediatr. 2019 Nov 18. doi: 10.1111/apa.15098. [Epub ahead of print] Review.
PMID: 31737940
Select item 31740945
Liu X, Yuan H, Chen J, Cen J, Nie Z, Xu G, Wen S, Zhuang J.
Eur J Cardiothorac Surg. 2019 Nov 18. pii: ezz310. doi: 10.1093/ejcts/ezz310. [Epub ahead of print]
PMID: 31740945
Select item 31767384
Cantinotti M, Giordano R, Marchese P, Franchi E, Viacava C, Pak V, Murzi B, Arcieri L, Poli V, Federici D, Koestenberger M, Assanta N.
J Cardiothorac Vasc Anesth. 2019 Nov 18. pii: S1053-0770(19)31156-5. doi: 10.1053/j.jvca.2019.11.009. [Epub ahead of print]
PMID: 31812566
Select item 31798834
Comentale G, Giordano R, Pilato E, D’Amore A, Romano R, Simeone S, Browning R, Palma G, Iannelli G.
Heart Fail Rev. 2019 Nov 16. doi: 10.1007/s10741-019-09892-0. [Epub ahead of print] Review.
PMID: 31734755
Select item 31785955
Elassal AA, Al-Radi OO, Dohain AM, Abdelmohsen GA, Al-Ebrahim KE, Eldib OS.
J Card Surg. 2019 Nov 15. doi: 10.1111/jocs.14338. [Epub ahead of print]
PMID: 31730717
Select item 31732917
Zloto K, Tirosh-Wagner T, Bolkier Y, Bar-Yosef O, Vardi A, Mishali D, Paret G, Nevo-Caspi Y.
J Cardiovasc Transl Res. 2019 Nov 15. doi: 10.1007/s12265-019-09921-1. [Epub ahead of print]
PMID: 31732917
Select item 31740142
Matsumoto MM, Milner R.
EJVES Short Rep. 2019 Nov 12;45:26-29. doi: 10.1016/j.ejvssr.2019.10.003. eCollection 2019.
PMID: 31768425 Free PMC Article
Select item 31713633
Wolfe KR, Kelly SL, Steinberg E, Pliego J, Everitt MD.
Pediatr Transplant. 2019 Nov 12:e13615. doi: 10.1111/petr.13615. [Epub ahead of print]
PMID: 31713990
Select item 31713327
Riley CM, Mastropietro CW, Sassalos P, Buckley JR, Costello JM, Iliopoulos I, Jennings A, Cashen K, Suguna Narasimhulu S, Gowda KMN, Smerling AJ, Wilhelm M, Badheka A, Bakar A, Moser EAS, Amula V.
Congenit Heart Dis. 2019 Nov 11. doi: 10.1111/chd.12849. [Epub ahead of print]
PMID: 31713327
Select item 31726116
Bustillo MA, Hussain I, Virk MS, Fu KM, Scharoun JH.
World Neurosurg. 2019 Nov 9;134:302-307. doi: 10.1016/j.wneu.2019.11.004. [Epub ahead of print]
PMID: 31715418
Select item 31705178
Luo Q, Zhao W, Su Z, Liu Y, Jia Y, Zhang L, Wang H, Li Y, Wu X, Li S, Yan F.
Front Pediatr. 2019 Nov 7;7:456. doi: 10.3389/fped.2019.00456. eCollection 2019.
PMID: 31788459 Free PMC Article
Select item 31703697
Koski TK, Suominen PK, Raissadati A, Knihtilä HM, Ojala TH, Salminen JT.
Acta Anaesthesiol Scand. 2019 Nov;63(10):1384-1389. doi: 10.1111/aas.13431. Epub 2019 Jul 16.
PMID: 31271655
Select item 31520896
Castellanos DA, Ocampo EC, Gooden A, Wang Y, Qureshi AM, Heinle JS, Mery CM, Hill GD, Ghanayem NS.
Ann Thorac Surg. 2019 Nov;108(5):1423-1429. doi: 10.1016/j.athoracsur.2019.06.041. Epub 2019 Aug 7.
PMID: 31400339
Select item 31323213
Chew JD, Hill KD, Jacobs ML, Jacobs JP, Killen SAS, Godown J, Wallace AS, Thibault D, Chiswell K, Bichell DP, Soslow JH.
Ann Thorac Surg. 2019 Nov;108(5):1430-1437. doi: 10.1016/j.athoracsur.2019.05.047. Epub 2019 Jul 9.
PMID: 31299232
Select item 31279788
Mery CM, De León LE, Trujillo-Diaz D, Ocampo EC, Dickerson HA, Zhu H, Adachi I, Heinle JS, Fraser CD Jr, Ermis PR.
Ann Thorac Surg. 2019 Nov;108(5):1439-1446. doi: 10.1016/j.athoracsur.2019.05.039. Epub 2019 Jul 4.
PMID: 31279788
Select item 31243012
Binsalamah ZM, Spigel ZA, Zhu H, Kim MB, Chacon-Portillo MA, Adachi I, Imamura M, Mery CM, Mckenzie ED, Fraser CD, Heinle JS.
Cardiol Young. 2019 Nov;29(11):1391-1396. doi: 10.1017/S1047951119002336. Epub 2019 Sep 26.
PMID: 31554530
Select item 31554525
Ueno K, Shiokawa N, Takahashi Y, Nakae K, Kawamura J, Imoto Y, Kawano Y.
Clin Exp Nephrol. 2019 Nov 1. doi: 10.1007/s10157-019-01805-7. [Epub ahead of print]
PMID: 31677063
Select item 30980206
Cox K, Arunamata A, Krawczeski CD, Reddy C, Kipps AK, Long J, Roth SJ, Axelrod DM, Hanley F, Shin A, Selamet Tierney ES.
Echocardiography. 2019 Nov;36(11):2078-2085. doi: 10.1111/echo.14505. Epub 2019 Oct 19.
PMID: 31628768
Select item 31573705
Fuller S, Ramachandran A, Awh K, Faerber JA, Patel PA, Nicolson SC, O’Byrne ML, Mascio CE, Kim YY.
Eur J Cardiothorac Surg. 2019 Nov 1;56(5):891-897. doi: 10.1093/ejcts/ezz102.
PMID: 30957859
Select item 31603504
Ozawa H, Ueno T, Taira M, Toda K, Kuratani T, Sawa Y.
Gen Thorac Cardiovasc Surg. 2019 Nov;67(11):976-978. doi: 10.1007/s11748-018-0988-9. Epub 2018 Aug 13.
PMID: 30101363
Select item 31513339
van der Palen RLF, van der Bom T, Dekker A, Tsonaka R, van Geloven N, Kuipers IM, Konings TC, Rammeloo LAJ, Ten Harkel ADJ, Jongbloed MRM, Koolbergen DR, Mulder BJM, Hazekamp MG, Blom NA.
Heart. 2019 Nov;105(22):1732-1740. doi: 10.1136/heartjnl-2019-315157. Epub 2019 Jul 10.
PMID: 31292191 Free PMC Article
Select item 31278142
Ivanzov S, Soynov I, Kulyabin Y, Zubritskiy A, Voitov A, Omelchenko A, Arkhipov A, Bogachev-Prokophiev A.
Interact Cardiovasc Thorac Surg. 2019 Nov 1;29(5):776-782. doi: 10.1093/icvts/ivz167.
PMID: 31361302
Select item 31508848
Vida VL, Zanotto L, Zanotto L, Triglia LT, Bellanti E, Castaldi B, Padalino MA, Gasperetti A, Battista F, Varnier M, Stellin G.
J Card Surg. 2019 Nov;34(11):1154-1161. doi: 10.1111/jocs.14045. Epub 2019 Sep 11.
PMID: 31508848
Select item 31478249
Hiraoka A, Tachibana H, Yoshitaka H, Sakaguchi T.
J Card Surg. 2019 Nov;34(11):1352-1353. doi: 10.1111/jocs.14206. Epub 2019 Sep 3.
PMID: 31478249
Select item 31449703
Nam LL, Zimmerman SL, Sekar P, Hibino N.
J Card Surg. 2019 Nov;34(11):1380-1382. doi: 10.1111/jocs.14213. Epub 2019 Aug 26. No abstract available.
PMID: 31449693
Select item 31449687
Vettukattil JJ, Mohammad Nijres B, Gosnell JM, Samuel BP, Haw MP.
J Card Surg. 2019 Nov;34(11):1363-1369. doi: 10.1111/jocs.14180. Epub 2019 Aug 26.
PMID: 31449687
Select item 31421654
Bansal A, Akhtar F, Zwintscher NP, Young T, Patel R, Desai S.
J Card Surg. 2019 Nov;34(11):1383-1386. doi: 10.1111/jocs.14216. Epub 2019 Aug 17.
PMID: 31421654
Select item 31421653
Lim B, Forest SJ, Schultz ML, Lipsitz E, Michler RE.
J Card Surg. 2019 Nov;34(11):1374-1376. doi: 10.1111/jocs.14201. Epub 2019 Aug 17.
PMID: 31421653
Select item 31255458
- Structured review of post-cardiotomy extracorporeal membrane oxygenation: Part 2-pediatric patients.
Lorusso R, Raffa GM, Kowalewski M, Alenizy K, Sluijpers N, Makhoul M, Brodie D, McMullan M, Wang IW, Meani P, MacLaren G, Dalton H, Barbaro R, Hou X, Cavarocchi N, Chen YS, Thiagarajan R, Alexander P, Alsoufi B, Bermudez CA, Shah AS, Haft J, Oreto L, D’Alessandro DA, Boeken U, Whitman G.
J Heart Lung Transplant. 2019 Nov;38(11):1144-1161. doi: 10.1016/j.healun.2019.07.004. Epub 2019 Jul 17.
PMID: 31421976
Select item 31558080
Peng B, Wang Q.
J Int Med Res. 2019 Nov;47(11):5702-5710. doi: 10.1177/0300060518818021. Epub 2019 Sep 26. No abstract available.
PMID: 31558080 Free PMC Article
Select item 30900361
Fang A, Allen KY, Marino BS, Brady KM.
Paediatr Anaesth. 2019 Nov;29(11):1086-1093. doi: 10.1111/pan.13744. Epub 2019 Oct 8. No abstract available.
PMID: 31532867
Select item 31423753
Lunze FI, Narciso R, Gauvreau K, Blume ED, Colan SD, Singh TP.
Pediatr Transplant. 2019 Nov;23(7):e13543. doi: 10.1111/petr.13543. Epub 2019 Jul 16.
PMID: 31313435
Select item 31297930
Schubert S, Opgen-Rhein B, Boehne M, Weigelt A, Wagner R, Müller G, Rentzsch A, Zu Knyphausen E, Fischer M, Papakostas K, Wiegand G, Ruf B, Hannes T, Reineker K, Kiski D, Khalil M, Steinmetz M, Fischer G, Pickardt T, Klingel K, Messroghli DR, Degener F; MYKKE consortium.
Pediatr Transplant. 2019 Nov;23(7):e13548. doi: 10.1111/petr.13548. Epub 2019 Jul 11.
PMID: 31297930
Select item 31601612
Massey SL, Abend NS, Gaynor JW, Licht DJ, Nadkarni VM, Topjian AA, Xiao R, Naim MY.
Resuscitation. 2019 Nov;144:67-74. doi: 10.1016/j.resuscitation.2019.09.005. Epub 2019 Sep 24.
PMID: 31560988
Select item 31079145
Goldberg R, Kumar SR.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):731-732. doi: 10.1177/2150135119883622. No abstract available.
PMID: 31701839
Select item 31701836
Matsushima S, Burri M, Strbad M, Ruf B, Lange R, Hörer J, Cleuziou J.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):678-685. doi: 10.1177/2150135119872476.
PMID: 31701836
Select item 31701835
Mahajan P, Ebenroth ES, Borsheim K, Husain S, Bo N, Herrmann JL, Rodefeld MD, Turrentine MW, Brown JW, Patel JK.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):694-701. doi: 10.1177/2150135119874035.
PMID: 31701830
Select item 31701827
Lotto R, Jones I, Seaton SE, Dhannapuneni R, Guerrero R, Lotto A.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):669-677. doi: 10.1177/2150135119872489.
PMID: 31701827
Select item 31701826
Chivers SC, Pavy C, Vaja R, Quarto C, Ghez O, Daubeney PEF.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):724-730. doi: 10.1177/2150135119878108.
PMID: 31701826
Select item 31701823
Mylonas KS, Tzifa A.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):789-790. doi: 10.1177/2150135119872207.
PMID: 31701823
Knecht M, LaRochelle J, Barkemeyer B, Gupta R, Brumund M, Mumphrey C.
J Med Toxicol. 2019 Nov 26. doi: 10.1007/s13181-019-00742-x. [Epub ahead of print]
PMID: 31773636
Select item 31605580
Rao S, Stewart RD, Pettersson G, Tan C, Golz S, Komarlu R.
World J Pediatr Congenit Heart Surg. 2019 Nov 22:2150135119880547. doi: 10.1177/2150135119880547. [Epub ahead of print]
PMID: 31755355
Select item 31760054
Bates KE, Madsen NL, Khadr L, Gao Z, Crawford K, Gaies M, Graupe M, Hanke SP, Hlavacek AM, Morell E, Pasquali SK, Russell JL, Schachtner SK, Tanel RE, Ware AL, Kipps AK.
Ann Thorac Surg. 2019 Nov 21. pii: S0003-4975(19)31710-2. doi: 10.1016/j.athoracsur.2019.09.078. [Epub ahead of print]
PMID: 31760054
Select item 31760051
Knoll C, Kaufman B, Chen S, Murray J, Cohen H, Sourkes BM, Rosenthal DN, Hollander SA.
ASAIO J. 2019 Nov 20. doi: 10.1097/MAT.0000000000001092. [Epub ahead of print]
PMID: 31789655
Select item 31789654
Elassal AA, Al-Radi OO, Dohain AM, Abdelmohsen GA, Al-Ebrahim KE, Eldib OS.
J Card Surg. 2019 Nov 15. doi: 10.1111/jocs.14338. [Epub ahead of print]
PMID: 31730717
Select item 31732917
Weiner JG, Lambert AN, Thurm C, Hall M, Soslow JH, Reimschisel TE, Bearl DW, Dodd DA, Feingold B, Godown J.
J Pediatr. 2019 Nov 8. pii: S0022-3476(19)31339-3. doi: 10.1016/j.jpeds.2019.10.016. [Epub ahead of print]
PMID: 31711761
Select item 31705178
Pfister R, Kirsch M, Natterer J, Di Bernardo S, Pretre R.
Pediatr Cardiol. 2019 Nov 2. doi: 10.1007/s00246-019-02229-6. [Epub ahead of print]
PMID: 31679056
Select item 31676956
Devlin PJ, Jegatheeswaran A, Williams WG, Blackstone EH, DeCampli WM, Lambert LM, Mussatto KA, Prospero CJ, Bondarenko I, McCrindle BW.
Ann Thorac Surg. 2019 Nov;108(5):1447-1455. doi: 10.1016/j.athoracsur.2019.05.081. Epub 2019 Jul 23.
PMID: 31348901
Select item 31299232
Mery CM, De León LE, Trujillo-Diaz D, Ocampo EC, Dickerson HA, Zhu H, Adachi I, Heinle JS, Fraser CD Jr, Ermis PR.
Ann Thorac Surg. 2019 Nov;108(5):1439-1446. doi: 10.1016/j.athoracsur.2019.05.039. Epub 2019 Jul 4.
PMID: 31279788
Select item 30926474
Hopkins KA, Farber MO, Singh R, Kay WA, Herrmann JL, Brown JW.
Ann Thorac Surg. 2019 Nov;108(5):e319-e321. doi: 10.1016/j.athoracsur.2019.02.049. Epub 2019 Mar 25.
PMID: 30922823
Select item 30158137
Mazurak M, Kusa J.
Arch Dis Child. 2019 Nov;104(11):1096-1097. doi: 10.1136/archdischild-2018-315288. Epub 2018 Aug 29. No abstract available.
PMID: 30158137
Select item 31162850
Fox C, Sarkisyan H, Stevens R, Arabia F, Fischer W, Rossano J, Throckmorton A.
Artif Organs. 2019 Nov;43(11):1055-1064. doi: 10.1111/aor.13507. Epub 2019 Jul 16.
PMID: 31162850
Select item 30325847
Yılmaz M, Ziadinov E, Aykan HH.
Asian Cardiovasc Thorac Ann. 2019 Nov;27(9):776-778. doi: 10.1177/0218492319863600. Epub 2019 Jul 9. No abstract available.
PMID: 31288550
Select item 31072104
Chaiyakulsil C, Sirichongkolthong B.
Asian Cardiovasc Thorac Ann. 2019 Nov;27(9):760-763. doi: 10.1177/0218492319851380. Epub 2019 May 9. No abstract available.
PMID: 31072104
Select item 31391347
Bansal A, Akhtar F, Zwintscher NP, Young T, Patel R, Desai S.
J Card Surg. 2019 Nov;34(11):1383-1386. doi: 10.1111/jocs.14216. Epub 2019 Aug 17.
PMID: 31421654
Select item 31688514
Broda CR, Adachi I.
J Thorac Cardiovasc Surg. 2019 Nov;158(5):1422-1423. doi: 10.1016/j.jtcvs.2019.06.101. Epub 2019 Aug 8. No abstract available.
PMID: 31493880
Select item 31395365
Mahle WT, Mason KL, Dipchand AI, Richmond M, Feingold B, Canter CE, Hsu DT, Singh TP, Shaddy RE, Armstrong BD, Zeevi A, Iklé DN, Diop H, Odim J, Webber SA; CTOTC-04 Investigators.
Pediatr Transplant. 2019 Nov;23(7):e13561. doi: 10.1111/petr.13561. Epub 2019 Sep 4.
PMID: 31483086
Select item 31347255
Matsushima S, Burri M, Strbad M, Ruf B, Lange R, Hörer J, Cleuziou J.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):678-685. doi: 10.1177/2150135119872476.
PMID: 31701836
Select item 31701835
Agrawal G, Das A.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):801-802. doi: 10.1177/2150135119874033.
PMID: 31701832
Select item 31701828
Tume SC, Conway J, Ryan KR, Philip J, Fortkiewicz JM, Murray J.
World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):759-768. doi: 10.1177/2150135119880890. Epub 2019 Oct 30.
PMID: 31663841
Select item 31663840
Fetal Cardiology Featured Articles
Fetal cardiology and genetics Nov 2019
Papaz T, Liston E, Zahavich L, Stavropoulos DJ, Jobling RK, Kim RH, Reuter M, Miron A, Oechslin E, Mondal T, Bergin L, Smythe JF, Altamirano-Diaz L, Lougheed J, Yao R, Akinrinade O, Breckpot J, Mital S.
BMC Med Genomics. 2019 Nov 27;12(1):173. doi: 10.1186/s12920-019-0618-0.
PMID: 31775751 Free PMC Article
Select item 31785499
Hoppler S, Conlon FL.
Cold Spring Harb Perspect Biol. 2019 Nov 25. pii: a037200. doi: 10.1101/cshperspect.a037200. [Epub ahead of print]
PMID: 31767648
Select item 31768918
Richards B, Freel L, Stiver C, Texter K, Cua CL.
Int J Cardiol. 2019 Nov 21. pii: S0167-5273(19)33617-4. doi: 10.1016/j.ijcard.2019.11.119. [Epub ahead of print]
PMID: 31785958
Select item 31787590
Ishizaki-Asami R, Uchida K, Tsuchihashi T, Shibata A, Kodo K, Emoto K, Mikoshiba K, Takahashi T, Yamagishi H.
Dev Biol. 2019 Nov 20. pii: S0012-1606(19)30477-4. doi: 10.1016/j.ydbio.2019.11.011. [Epub ahead of print]
PMID: 31758944
Select item 31743550
Steurer MA, Peyvandi S, Baer RJ, Oltman SP, Chambers CD, Norton ME, Ryckman KK, Moon-Grady AJ, Keller RL, Shiboski SC, Jelliffe-Pawlowski LL.
J Am Heart Assoc. 2019 Nov 19;8(22):e013194. doi: 10.1161/JAHA.119.013194. Epub 2019 Nov 15.
PMID: 31726960 Free Article
Select item 31718438
Peng B, Han X, Peng C, Luo X, Deng L, Huang L.
J Cell Mol Med. 2019 Nov 19. doi: 10.1111/jcmm.14824. [Epub ahead of print]
PMID: 31746096 Free Article
Select item 31744358
Mardy C, Blumenfeld YJ, Arunamata AA, Girsen AI, Sylvester KG, Halabi S, Rubesova E, Hintz SR, Tacy TA, Maskatia SA.
Prenat Diagn. 2019 Nov 19. doi: 10.1002/pd.5612. [Epub ahead of print]
PMID: 31742724
Select item 31743523
Vigneswaran TV, Rosenthal E, Bakalis S, Nelson-Piercy C, Chappell L, Simpson JM.
Ultrasound Obstet Gynecol. 2019 Nov 19. doi: 10.1002/uog.21924. [Epub ahead of print] No abstract available.
PMID: 31743523
Select item 31737940
Shuplock JM, Kavanaugh-McHugh A, Parra D.
Pediatr Cardiol. 2019 Nov 14. doi: 10.1007/s00246-019-02252-7. [Epub ahead of print]
PMID: 31728571
Select item 31742315
Baard J, Azibani F, Osman A, Dowling W, Rayner B, Sliwa K.
Cardiovasc J Afr. 2019 Nov 13;30:1-6. doi: 10.5830/CVJA-2019-061. [Epub ahead of print]
PMID: 31742315 Free Article
Select item 31722548
Deuitch N, Soo-Jin Lee S, Char D.
J Genet Couns. 2019 Nov 7. doi: 10.1002/jgc4.1182. [Epub ahead of print]
PMID: 31701594
Select item 31734303
Kang K, Chuai JB, Xie BD, Li JZ, Qu H, Wu H, Fang SH, Cui JJ, Xiu LL, Han JC, Cao TH, Leng XP, Tian H, Li RK, Jiang SL.
Biomaterials. 2019 Nov 6:119574. doi: 10.1016/j.biomaterials.2019.119574. [Epub ahead of print]
PMID: 31761487
Select item 31709041
You W, Andescavage NN, Kapse K, Donofrio MT, Jacobs M, Limperopoulos C.
Radiology. 2019 Nov 5:190751. doi: 10.1148/radiol.2019190751. [Epub ahead of print]
PMID: 31687920
Select item 31679544
Lupo PJ, Mitchell LE, Jenkins MM.
Birth Defects Res. 2019 Nov 1;111(18):1329-1342. doi: 10.1002/bdr2.1606. Epub 2019 Oct 25. Review.
PMID: 31654503
Select item 31580536
Xia Y, Chen S, Yang Y, Wu Y, Huang S, Wang Y, Ding H, He W, Li P, Zhuang J.
Circ Genom Precis Med. 2019 Nov;12(11):e002732. doi: 10.1161/CIRCGEN.119.002732. Epub 2019 Oct 22. No abstract available.
PMID: 31638415
Select item 31658832
Li T, Han J, Gao S, Hao X, He Y.
Echocardiography. 2019 Nov;36(11):2114-2117. doi: 10.1111/echo.14513. Epub 2019 Nov 8.
PMID: 31705550
Select item 31628768
Kumar S, Lodge J.
J Matern Fetal Neonatal Med. 2019 Nov;32(22):3871-3881. doi: 10.1080/14767058.2018.1472224. Epub 2018 May 15.
PMID: 29716424
Select item 31404639
Cuneo BF, Olson CA, Haxel C, Howley L, Gagnon A, Benson DW, Kaizer AM, Thomas JF.
Obstet Gynecol. 2019 Nov;134(5):1096-1103. doi: 10.1097/AOG.0000000000003502.
PMID: 31599844
Select item 31599832
Cawyer CR, Kuper SG, Ausbeck E, Sinkey RG, Owen J.
Prenat Diagn. 2019 Nov;39(12):1148-1154. doi: 10.1002/pd.5557. Epub 2019 Sep 13.
PMID: 31499581
Select item 31557688
Day TG, Charakida M, Simpson JM.
Ultrasound Obstet Gynecol. 2019 Nov;54(5):575-581. doi: 10.1002/uog.20233. No abstract available.
PMID: 30740804
Select item 30549363
Zidere V, Gebb J, Vigneswaran T, Charakida M, Simpson JM, Bower S.
Ultrasound Obstet Gynecol. 2019 Nov;54(5):701-702. doi: 10.1002/uog.20194. No abstract available.
PMID: 30549363
Select item 31701840
Goldsher YW, Salem Y, Weisz B, Achiron R, Jacobson JM, Gindes L.
J Clin Ultrasound. 2019 Nov 28. doi: 10.1002/jcu.22800. [Epub ahead of print]
PMID: 31777971
Select item 31781767
Silva JA, Neves AL, Flor-de-Lima F, Soares P, Guimarães H.
Pediatr Cardiol. 2019 Nov 25. doi: 10.1007/s00246-019-02239-4. [Epub ahead of print]
PMID: 31768578
Select item 31744280
Fouron JC, Thomas-Chabaneix J, Brisebois S, Berger A, Dahdah N.
Pediatr Cardiol. 2019 Nov 16. doi: 10.1007/s00246-019-02257-2. [Epub ahead of print]
PMID: 31732764
Select item 31732763
Minsart AF, Boucoiran I, Delrue MA, Audibert F, Abadir S, Lapierre C, Lemyre E, Raboisson MJ.
Pediatr Cardiol. 2019 Nov 13. doi: 10.1007/s00246-019-02246-5. [Epub ahead of print]
PMID: 31720744
Select item 31714687
Lachaud M, Dionne A, Brassard M, Charron MA, Birca A, Dehaes M, Raboisson MJ.
Ultrasound Obstet Gynecol. 2019 Nov 11. doi: 10.1002/uog.21920. [Epub ahead of print]
PMID: 31710736
Select item 31709689
Bichali S, Grigorescu RC, Lefebvre M, Oriot C, Dhombres F, Bonnet D, Houyel L.
Cardiol Young. 2019 Nov 4:1-3. doi: 10.1017/S1047951119002488. [Epub ahead of print]
PMID: 31679548
Select item 31679544
van der Palen RLF, van der Zee C, Vink AS, Knobbe I, Jurgens SJ, van Leeuwen E, Bax CJ, du Marchie Sarvaas GJ, Blom NA, Haak MC, Bilardo CM, Clur SB.
Prenat Diagn. 2019 Nov;39(12):1054-1063. doi: 10.1002/pd.5539. Epub 2019 Aug 7.
PMID: 31351016
Select item 31385648
Congenital Cardiovascular Anesthesia and Critical Care Featured Articles
Congenital Heart and Pediatric Cardiac Anesthesia and Intensive Care Reviews for December 2019
Wu L, Hou Q, Bai J, Zhang J, Sun L, Tan R, Zhang M, Zheng J.
Pediatr Crit Care Med. 2019 May;20(5):442-449. doi: 10.1097/PCC.0000000000001865.
PMID: 31058784
Take Home Points:
- The most prevalent region of post-intubation atelectasis in pediatric patients (3 months to 3 years old) undergoing pediatric cardiac surgery under general anesthesia is the posterior inferior region of the lung. Lung ultrasound (LUS) along the posterior axillary line at the intercostal fifth, sixth, and seventh spaces showed an incidence of atelectasis of 60-62.5%, 57.5-60% and 37.5% respectively, whereas LUS in the anterior or lateral regions rarely presented atelectasis (0-7.5%).
- Post-intubation addition of 5 cm H2O positive end-expiratory pressure (PEEP) in pressure-controlled ventilated pediatric patients under general anesthesia significantly reduced the incidence of atelectasis in high prevalence areas of the lung (posterior and inferior). This simple beneficial intervention can improve lung aeration and decreases the incidence of postoperative atelectasis. In addition, this low level PEEP was not associated with hemodynamic compromise in pediatric cardiac patients.
Commentary by Pablo Motta, MD a pediatric cardiac anesthesiologist at Texas Children’s Hospital in Houston Texas / Baylor College of Medicine: Lung ultrasound (LUS) is a radiation-free tool used to diagnose pulmonary disease in the perioperative setting. Common diagnoses identified by LUS include pulmonary edema, atelectasis, pneumothorax and effusion. LUS has become a preferred alternative to CT in terms of accuracy and reliability and outperforms chest radiography in the critical care setting.
Atelectasis is one of the most common complications in pediatric patients undergoing general anesthesia either with an endotracheal tube or laryngeal mask, with an incidence of 68 –100%. Atelectasis compromises gas exchange, worsens lung mechanics and increases the risk of lung inflammation. Usually the effect of atelectasis is self-limited in otherwise healthy pediatric patients but can hinder the recovery of pediatric cardiac surgery patients. Furthermore, this group of patients is at an even higher risk of atelectasis due to surgical manipulation and lung collapse during cardiopulmonary bypass (CPB). Lung recruitment maneuvers have been described in the adult cardiac surgery population but there is little evidence in the pediatric cardiac surgical population.
In this single institution randomized control trial, the authors prospectively studied pediatric congenital heart disease (CHD) patients between the ages of 3 months to 3 years old scheduled for elective cardiac surgery with CPB under general anesthesia. Patients undergoing emergency surgery or who had a previous respiratory infection, pulmonary disease, genetic disorders, thoracic cage anomalies or abnormal lung imaging were excluded. The goals of the study were to: first, define the most useful lung region/s to diagnose atelectasis by LUS; second, compare the effects of pressure-controlled ventilation with and without low-level PEEP on lung aeration.
Forty patients were randomly allocated to either a control or intervention group. The control group was placed on 0 cm H2O PEEP while the intervention group was placed on 5 cm H2O PEEP just after intubation. Both groups had a LUS examination performed by the same experienced anesthesiologist 1-minute and 15-minutes post-intubation following induction of general anesthesia. Six areas of the lung were examined bilaterally for a total of twelve scanned areas: anteriorly at clavicular midline region (scans 1 and 2), laterally at the middle axillary catheter region (scan 3), posteriorly at the posterior axillary line at the fifth, sixth, and seventh intercostal spaces (scans 4–6). The ventilation management was the same pressure control ventilation (PCV) with a peak inspiratory pressure to achieve a tidal volume of 8–10 mL/kg and an end-tidal CO2 of 35–45 mm Hg. The frequency was set at a rate of 16–30 breaths/min depending on the patient’s age and the inspiratory: expiratory ratio of 1:2. Furthermore the intervention group was maintained on 5 cm H2O PEEP after intubation until the second LUS.
The results were as predicted, with the most prevalent area for atelectasis being inferoposterior (Scans 4-6) with an incidence between 37.5 to 62.5%. Almost no atelectasis was visualized in the anterior and lateral regions of the lung. The addition of low-level PEEP of 5 cm H20 decreased the incidence of atelectasis in scans 4, 5, and 6 from 62.5% to 45% (p = 0.02), 60% to 27.5% (p = 0.002), and 35% to 20% (p = 0.035), respectively. No deleterious hemodynamic effects were seen with the level of PEEP used, but atelectasis persisted in a substantial group of patients (~30%). In addition. the authors calculated a lung aeration score and the atelectatic area. PCV with PEEP significantly reduced lung aeration scores from 13 (8.3-17.5) to 8 (3.3-9.8) and the atelectatic areas bilaterally from 128 mm2 (34.5–213.3 mm2) to 49.5 mm2 (5.3–75.5 mm2).
Research shortcomings include being a single center study with a small sample size and having a single non-blinded anesthesiologist interpreting the images with its potential bias. The study population was not homogenous since it had wide age variation (3 month to 3 years), with the consequent size difference, and a mix of CHD (cyanotic and acyanotic). The intervention was brief (only 15 minutes of PEEP) leaving a substantial group of patients with persistent atelectasis (~30%). This poses the question whether higher levels of PEEP are necessary to completely eliminate atelectasis or if low-level PEEP for a longer period of time could resolve it.
Interestingly the study opens up the question if LUS should become a standard of care in the pediatric cardiac operating room to allow early diagnosis of atelectasis. Ultimately, this demands further investigations to determine the optimal level of PEEP required to completely resolve atelectasis without causing hemodynamic compromise.
Tirotta CF, Lagueruela RG, Madril D, Salyakina D, Wang W, Taylor T, Ojito J, Kubes K, Lim H, Hannan R, Burke R.
Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029618816382. doi: 10.1177/1076029618816382. Epub 2018 Dec 5.
PMID: 30518238
Take Home Points:
- Normal plasma fibrinogen levels as measured by the Clauss method are well defined for pediatric surgical populations, but measurement is not available for point-of-care (POC) testing.
- The FIBTEM assay of rotational thromboelastometry (ROTEM) is a POC test that provides immediate results for transfusion guidance during pediatric cardiac surgery, but normal values in children have not been widely established.
- Paired plasma fibrinogen and FIBTEM maximum clot firmness (MCF) levels were used to create an equation to predict plasma fibrinogen concentration for a given MCF, enabling application of POC ROTEM to immediate goal-directed transfusion.
Commentary by Kelly A. Machovec, MD, MPH, Associate Professor of Anesthesiology at Duke University Medical Center: Rotational thromboelastometry (ROTEM, Instrumentation Laboratory, Bedford, MA, USA) is a viscoelastic test used to monitor bleeding, coagulation and transfusion in the surgical or trauma setting. The FIBTEM assay of ROTEM assesses the functionality and stability of fibrin polymerization. The FIBTEM assay is conducted by tissue factor activation of the whole blood sample, followed by addition of cytochalasin D to inhibit the platelet contribution to clot strength, thus isolating the fibrin contribution. POC ROTEM has been validated against laboratory ROTEM, but ROTEM FIBTEM values have not been validated against plasma fibrinogen concentration as measured by the Clauss method. The authors of this study aimed to correlate MCF of the FIBTEM with plasma fibrinogen levels by the Clauss method in order to develop an equation to predict plasma fibrinogen levels from FIBTEM MCF results.
This single center retrospective chart review examined consecutive patient charts over a 7-month period. All charts of children 5 years old or less having cardiac surgery with peri-operative fibrinogen and FIBTEM values were included. Time points of interest were prior to cardiopulmonary bypass (CPB) initiation, during CPB, and post-CPB separation. Plasma fibrinogen levels were obtained in the laboratory using the Stago STA compact system, which uses a modified Clauss method to determine the fibrinogen concentration of a given blood sample. The study team reviewed 50 charts, and found 27 patients who had a total of 87 incidences where FIBTEM MCF and plasma fibrinogen levels were obtained at the same time and could therefore be compared.
Plasma fibrinogen levels and FIBTEM MCF values were found to be normally distributed by the Kolmogorov-Smirnov test. Mean plasma fibrinogen was 178.1 mg/dl +/- 76.4. Mean FIBTEM MCF was 8 mm +/- 4.3. Linear regression of FIBTEM MCF and plasma fibrinogen showed a positive linear correlation.
The authors then moved to the prediction equation. First, simple linear regression was used to determine if FIBTEM MCF predicts plasma fibrinogen levels. Then, this information was used to develop a regression equation to predict the plasma fibrinogen level given a FIBTEM MCF value. Repeated 10-fold cross validation was used to develop, train and test the predictive equation. The final model suggested the following equation can be used to predict plasma fibrinogen given FIBTEM MCF:
Plasma fibrinogenmg/dl = 78.6 + 12.4 (MCFmm)
The finding that plasma fibrinogen level correlates with FIBTEM MCF is consistent with other studies in both pediatric and adult patients. This study, however, takes this relationship one step further by creating an equation to predict plasma fibrinogen from FIBTEM MCF. This is clinically important because normal ROTEM values for pediatric populations are not clearly defined, which limits its utility as a POC assay. In contrast, normal pediatric plasma fibrinogen levels are well defined, but are not readily obtained.
The ability to rapidly translate FIBTEM MCF into a plasma fibrinogen level may aid the physician in interpreting this information and making prompt clinical decisions. Importantly, because the FIBTEM amplitude at 5, 10, and 15 minutes after clotting time correlates with the final MCF, early FIBTEM POC values can be used to support a goal-directed transfusion practice. The authors provide the example of human fibrinogen concentrate: POC ROTEM can be used to estimate plasma fibrinogen level, which can then be used to calculate an accurate dose of human fibrinogen concentrate to raise plasma fibrinogen levels to the desired target level, rather than giving the standard 70 mg/kg dose. One caveat that the authors acknowledge is that Factor XIII, at low levels in infants and children after CPB, affects FIBTEM results but has no effect on the plasma fibrinogen level as determined by Clauss method.
The relationship between ROTEM FIBTEM and plasma fibrinogen level must be further explored, and the proposed predictive equation tested in a larger pediatric population.
Near-infrared spectroscopy for prediction of extubation success after neonatal cardiac surgery.
Gradidge EA, Grimaldi LM, Cashen K, Gowda KMN, Piggott KD, Wilhelm M, Costello JM, Mastropietro CW.
Cardiol Young. 2019 Jun;29(6):787-792. doi: 10.1017/S1047951119000829. Epub 2019 Jun 6.
PMID: 1169104
Take Home Points:
- Extubation failure after neonatal cardiac surgery is high, with more than 1 out of 10 neonates failing extubation. While there is consensus in the literature on the criteria for the need for mechanical ventilation in the critically ill neonate, there is no consensus on the criteria for weaning from mechanical ventilation and extubation readiness of neonates.
- A secondary analysis on previously collected multi-center prospective observational data in neonates after cardiac surgery evaluated NIRS as a parameter to predict extubation success. An increase in cerebral NIRS of ≥ 5% from baseline at the time of extubation was 98% predictive of extubation success. However, this change was present in only half of the neonates successfully extubated, indicating a low negative predictive value. Changes in renal regional oximetry were not prognostic of extubation outcome.
Commentary from Olga Pawelek, M.D. and Nischal Gautam, M.D., pediatric cardiac anesthesiologists at the McGovern Medical School/ Children’s Memorial Hermann, Houston, Texas: Over the past decade, great strides have been made in the perioperative care of neonates undergoing cardiac surgery to decrease mortality2. Despite this success, failure to extubate after neonatal cardiac surgery remains a significant complication and is reported anywhere between 6-21%3. Extubation failure and prolonged mechanical ventilation impact hospital length of stay and are associated with increased morbidity and mortality. Both modifiable and non-modifiable risk factors, such as hypoxic insults from birth or during surgery, genetic abnormalities, age, weight, and anatomic variants, heavily influence postoperative outcomes such as extubation success and the need for prolonged intensive care 2. These factors along with the high extubation failure rate after neonatal cardiac surgery suggest that a prognostic factor is needed to help determine the timing or readiness for tracheal extubation. Various measures, including neuromuscular function, oxygenation, and ventilation indices, have been examined as potential extubation readiness tools, however they have not been proven reliable.
Gradidge et al.’s results stem from a secondary analysis of prospectively collected cross-sectional data on neonates who underwent cardiac surgery at seven US tertiary children’s hospitals over one year (2015). Baseline or pre-incision cerebral and renal oximetry values using the INVOS oximeter probes were compared to another set in the intensive care unit at a time closest to extubation. Since the analysis was observational, there was not a consistent extubation protocol. Extubation failure was defined as a need for unplanned reintubation within 72 hours of planned extubation.
In this cohort of 159 patients, extubation failure after neonatal cardiac surgery was reported at 9.4%, which is similar to other studies 4. Baseline oximetry values and patient characteristics such as age, weight, duration of cardiopulmonary bypass and cross-clamp times had no impact on extubation outcomes. At the time of extubation, both cerebral and renal oximetry values were higher than baseline in patients extubated successfully and lower than baseline in patients who failed extubation. An increase in cerebral NIRS of ≥ 5% from baseline at the time of extubation was found to be predictive of extubation success. While this was 92% specific, with a 98% positive predictive value of extubation success, it was only 50% sensitive. After adjusting for variables, this ≥5% change was independently associated with extubation success (odds ratio of 10.9). By contrast, an increase in renal NIRS was a poor predictor of extubation success.
What does this mean for us?
Staged weaning from mechanical ventilation consists of measuring the potential cushion in the cardiopulmonary reserves to accommodate for the increased oxygen consumption from the work of spontaneous ventilation. In neonates tottering on the margins of critical oxygen delivery when oxygen extraction is at its maximum, especially in the heavily auto-regulated areas of the brain, it is not unusual for the mixed venous oxygen saturation to be lower at the time of extubation. Once the noxious stimulus of the endotracheal tube is removed and considering adequate pain control, it should be expected that the oxygen consumption and extraction decrease and the oxygen supply/consumption ratio is restored above anaerobic or critical levels. Given these assumptions, should a change in regional oximetry from baseline at the time of extubation be predictive of extubation success? The authors confirm that extubation failure after cardiac surgery is indeed high, and that 1 in 10 neonates will fail extubation after cardiac surgery. One of the significant takeaways from Gradidge et al. study is that there potentially exists a feel-good factor for extubation success when a ≥ 5% positive change in cerebral oximetry is observed at the time of extubation. This positive change metric was 98% predictive in determining extubation success. This high level of specificity could add another parameter to the checklist for extubation readiness.
However, some major limitations need to be addressed before we consider this metric as a tool for extubation. In this study, more than 50% of the neonates were extubated successfully even when this magnitude of change in oximetry was not present. Why did the metric fail to predict extubation in these patients? Similarly, why was the negative predictive value low for this metric? There could be many reasons for these observations. The data analysis was based on a prospective observational study and had many limitations based on the accuracy of the NIRS technology, especially during states of agitation and wakefulness. The secondary analysis was not adequately powered for this outcome. The retrospective nature of the study could have led to convenience-based sampling bias. There was no standardized extubation protocol or a re-intubation protocol across the seven centers. This lack of standardization of the weaning process could lead to significant differences in patient management across the centers and therefore result in variable outcomes. Lastly, the authors compare baseline values, when neonates were intubated, deeply sedated, well-oxygenated/ventilated, to values at the time of extubation, when neonates were nearly awake or agitated. In the postoperative period after neonatal cardiac surgery, the cerebral metabolic oxygen consumption rate is increased and can last many days. It is possible that the brain auto-regulates by increasing cerebral oxygen extraction, therefore expected increases in cerebral regional oximetry may not occur even if corrective surgeries increase systemic oxygen saturation. To validate this, a recently published prospective observational study5 analyzed oximetry changes after the correction of cyanotic congenital heart disease. Wong et al., observed that although the systemic oxygen saturation increased significantly to near normal values after correction of cyanotic heart disease, the cerebral and renal oximetry values did not increase but rather decreased compared to baseline at the time of discharge.
In conclusion, cerebral NIRS monitoring and change from baseline may be predictive of extubation success and used as one of the factors during assessment of neonates’ readiness to extubate. Future prospective trials powered to study the impact of regional oximetry as a tool for extubation readiness should be encouraged.
References:
- Gradidge EA, Grimaldi LM, Cashen K, Gowda KMN, Piggott KD, Wilhelm M, Costello JM, Mastropietro CW: Near-infrared spectroscopy for prediction of extubation success after neonatal cardiac surgery. Cardiology in the young 2019; 29:787–92
- Blinder JJ, Thiagarajan R, Williams K, Nathan M, Mayer J, Kulik TJ: Duration of Mechanical Ventilation and Perioperative Care Quality After Neonatal Cardiac Operations. Ann Thorac Surg 2017; 103:1956–62
- Miura S, Hamamoto N, Osaki M, Nakano S, Miyakoshi C: Extubation Failure in Neonates After Cardiac Surgery: Prevalence, Etiology, and Risk Factors. Ann Thorac Surg 2017; 103:1293–8
- Mastropietro CW, Cashen K, Grimaldi LM, Narayana Gowda KM, Piggott KD, Wilhelm M, Gradidge E, Moser EAS, Benneyworth BD, Costello JM: Extubation Failure after Neonatal Cardiac Surgery: A Multicenter Analysis. J Pediatr 2017; 182:190–4
- Wong JJ-M, Chen CK, Moorakonda RB, Wijeweera O, Tan TYS, Nakao M, Allen JC, Loh TF, Lee JH: Changes in Near-Infrared Spectroscopy After Congenital Cyanotic Heart Surgery. Front Pediatr 2018; 6:97
Anesthesia critical care Nov 2019
Boyer TJ, Kritzmire SM.
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.
2019 Nov 10.
PMID: 31082074 Free Books & Documents
Select item 31707723
Edelman B, Selvaraj BJ, Joshi M, Patil U, Yarmush J.
Anesthesiol Res Pract. 2019 Nov 3;2019:8621801. doi: 10.1155/2019/8621801. eCollection 2019. Review.
PMID: 31781201 Free PMC Article
Select item 31734051
Nawrocki P, Wisniewski K, Schmidt C, Bruenen A, Debus V, Malec E, Januszewska K.
Eur J Cardiothorac Surg. 2019 Nov 1;56(5):904-910. doi: 10.1093/ejcts/ezz139.
PMID: 31323661
Select item 30932159
The CHIP Network Journal Watch Team
Konstantin Averin, MD, MS is an Associate Professor of Pediatrics at the University of Alberta and an Interventional Pediatric Cardiologist at the Stollery Children’s Hospital in Edmonton, Alberta. He received his medical degree from the Feinberg School of Medicine at Northwestern University in Chicago, IL. After medical school, he completed pediatrics residency, pediatric cardiology fellowship and sub-specialty training in pediatric and adult interventional cardiology at the Cincinnati Children’s Hospital in Cincinnati, OH. His clinical and research interests are focused on the percutaneous treatment of pediatric patients with congenital and acquired heart disease with a focus on patients with single ventricle physiology, transcatheter pulmonary valves, and pulmonary hypertension.
Dr. Leong Ming Chern “MC” is an adult congenital heart disease specialist at the National Heart Institute, Kuala Lumpur, Malaysia. He received his medical training at the University of Malaya and pediatric cardiology training at the National Heart Institute. His area of interest includes treatment of adult patients with congenital heart disease and pulmonary hypertension in congenital heart disease.
Dr. Damien Cullington, MBChB MRCP MD FESC is a consultant adult congenital cardiologist who works at Leeds General Infirmary, UK. In summer 2019, he will move over to the newly commissioned North West ACHD Service based in Liverpool, UK. Damien qualified in 2002 from the University of Liverpool and became a substantive consultant in 2016. Prior to this, he worked throughout the North of England and Yorkshire as a cardiology trainee. Damien was awarded a doctorate in medicine (MD) from the University of Hull in 2013 for his work in heart rate in patients with heart failure. He is a member of the Royal College of Physicians (London), Fellow of the European Society of Cardiology and honorary senior lecturer for the University of Leeds. His ACHD subspecialty clinical interests are heart failure, imaging and palliative care. He is regional organiser for ACHD training at Leeds and clinical governance lead for the Leeds congenital cardiac unit. His research interests and wide and far but particularly epidemiology, chronic heart failure in ACHD patients in all its guises, the systemic RV and the univentricle
Dr. Blanche Cupido is a consultant adult cardiologist working at Groote Schuur Hospital, UCT Private Academic Hospital and the University of Cape Town(UCT), South Africa. She completed her physician training in 2009 and her cardiology subspecialist training in 2013. She recently returned to SA after doing a Fellowship in Adult Congenital Heart Disease in Leeds, United Kingdom under the guidance of Dr Kate English. She has established a dedicated unit for Grown Up Congenital Heart Disease in Cape Town, South Africa. Her aim is to grow ACHD services in Sub-Saharan Africa and embark on GUCH research on the African continent.
Dr. Jeremy L. Herrmann is an Assistant Professor of Surgery in the Division of Thoracic and Cardiovascular Surgery at Indiana University. He specializes in pediatric and adult congenital cardiac surgery, and his clinical interests also include heart transplantation and mechanical circulatory support. His hospital affiliations include Indiana University Health Riley Hospital for Children and Methodist Hospital as well as Peyton Manning Children’s Hospital at St. Vincent Hospital in Indianapolis
Maan Jokhadar is a cardiologist and associate professor of medicine at Emory University in Atlanta, Georgia. He is board certified in internal medicine, cardiovascular disease, advanced heart failure/transplantation, adult congenital heart disease, and echocardiography. He is fellowship director for the Emory Adult Congenital Heart Disease training program and Core Curriculum Director for the Emory general cardiology fellowship program. Dr Jokhadar graduated from the University Damascus School of Medicine in Syria and then went to Mayo Clinic in Rochester, Minnesota for internal medicine residency. He then completed cardiology and subspecialty training at Emory University, where he currently on faculty. Dr. Jokhadar has been the recipient of numerous teaching awards. He is married with 3 children.
Michael Ma, MD is an Assistant Professor in Cardiothoracic Surgery in the Division of Pediatric Cardiac Surgery at Stanford University. He specializes in pediatric and adult congenital cardiac surgery, with an emphasis on neonates, complex biventricular repair, and pulmonary artery reconstruction. His research lab investigates ex and in vivo translational models for complex congenital heart disease, to optimize future surgical and endovascular repair strategies.
Jeremy P. Moore MD MS FHRS is the Director of Clinical Research and faculty in Pediatric Cardiology and Adult Congenital Heart Disease at the University of California, Los Angeles. Dr. Moore received his medical degree from the Medical College of Virginia in 2003. He completed residency and fellowship at UCLA before pursuing his subspecialty training in Pediatric Electrophysiology at Vanderbilt University in 2009. Dr. Moore has been faculty at UCLA since 2010 and has since published numerous research manuscripts dealing with electrophysiologic aspects pertinent to congenital heart disease. Dr. Moore’s primary interest is the study of mechanisms of arrhythmia, and the development of novel electrophysiologic techniques for management of the adult patient with congenital heart disease
Dr. Mehul Patel MD, is a structural and adult congenital heart disease specialist and an interventional cardiologist. Dr. Patel earned his undergraduate and medical education from the Mumbai University, India. After completing his post-graduate training in Internal Medicine and Cardiology, he further trained in interventional cardiology at the Mount Sinai Medical Center, NYC, NY and Adult Congenital Heart Disease at the Texas Children’s Hospital, Texas Heart Institute, Baylor College of Medicine, Houston, TX. Dr. Patel worked as Chief of adult congenital heart disease, Assistant Professor at the Michigan State University, Grand Rapids, MI where he not only expanded the program, performing complex interventions and device implantations but also established the percutaneous pulmonary valve implantation (Melody Valve) Program. Due to his passion for treating structurally abnormal hearts, he did a dedicated year of Structural Heart Disease fellowship at Henry Ford Hospital, Detroit, MI where he worked with pioneers in this field before moving to North Carolina. He is proficient in performing transcatheter aortic valve replacement (TAVR), MitraClip, Watchman device implantation, percutaneous Mitral, Tricuspid and Pulmonary valve replacements along with a variety of interventions on congenital heart disease and pulmonary hypertension. Dr. Patel is ABIM board certified in Internal Medicine, Cardiology, Interventional cardiology and Adult Congenital Heart Disease. Dr. Patel has more than 50 peer reviewed publications and numerous abstracts to his credit. He serves as a Co-Editor-in-Chief for the CHiP Network journal watch. His wife, Khyati is a pediatric cardiac Electrophysiologist and they have a 9-year-old daughter. Dr. Patel is also an artist, likes music, yoga and plays badminton. His clinical areas of expertise and interests are: 1) Transcatheter therapies for Structural and Adult Congenital heart disease. 2) Complex device implantations.
Dr. Timothy Pirolli is an Assistant Professor of Surgery in the Division of Pediatric Cardiothoracic Surgery at University of Texas Southwestern Medical Center. He specializes in pediatric and adult congenital cardiac surgery. His hospital affiliations include Children’s Medical Center in Dallas, Parkland Memorial Hospital, and Clements University Hospital (UTSW).
Dr. Inga Voges, M.D. Consultant in Pediatric Cardiology, Lead Consultant Cardiovascular MRI. I trained in General Pediatrics and Pediatric Cardiology in Rostock (Germany) and Kiel (Germany) from 2002-2010 and did additional training in Adult Congenital Heart Disease (ACHD) in Kiel (Germany) which I finished in 2014. I specialized in Cardiovascular Magnetic Resonance Imaging (CMR) and have a further special interest in cardiomyopathies. Currently, I am working as a consultant pediatric and ACHD cardiologist at the University Hospital Schleswig-Holstein (Kiel, Germany) where I am responsible for the CMR imaging program in pediatric and ACHD patients and contribute to the care of patients with acquired and congenital heart disease. I received my MD from the Medical University Luebeck in 2006 (Germany) and finished my “Habilitation” (PhD equivalent; University Hospital Kiel, Germany) in 2014. Since 2016, I am the secretary of the Association for European Paediatric and Congenital Cardiology Imaging Working Group.
Dr. Gary Webb, M.D. is an Emeritus Professor of Pediatrics and Internal Medicine at the University of Cincinnati College of Medicine and,
from 2009-2016, the Director of the Adult Congenital Heart Program at Cincinnati Children’s Hospital Heart Institute. A graduate of McGill
University in Montréal, he interned at the Royal Victoria Hospital, and then trained in internal medicine and cardiology at the University of Toronto. From 1980-2004, he was co-director and then director of the Toronto Congenital Cardiac Center for Adults at Toronto General Hospital. He is a Fellow of the Royal College of Physicians and Surgeons of Canada in both internal medicine and cardiology. From 2004-2009, he was director of the Philadelphia Adult Congenital Heart Center at the University of Pennsylvania. Since 2016, he has been a consultant to Cincinnati Children’s Hospital, and has been responsible for the ACHD Learning Center, the Cardiology Fellow Testing Center, and the Congenital Heart Professionals International (CHIP) Network. Since 2017, he has resumed seeing patients on a part-time basis at the Toronto Congenital Cardiac Centre for Adults.
Wendy Whiteside, MD Wendy is Assistant Professor of Pediatrics and Associate Director of Interventional Pediatric Cardiology at the University of Michigan Congenital Heart Center, C.S. Mott Children’s Hospital. She obtained her medical degree from Albert Einstein College of Medicine in 2006 then completed pediatric residency at Children’s Hospital Oakland in Oakland, CA in 2009. She received
both her categorical and interventional pediatric cardiology training at the University of Michigan in Ann Arbor, MI. Her clinical and research interests include single ventricle physiology, transcatheter
pulmonary valves, and quality improvement within the cardiac catheterization laboratory.
About the Congenital Heart and Pediatric Cardiac Journal Watch
Congenital heart and pediatric cardiac Journal Watch was designed to make it easier for congenital heart and pediatric cardiac professionals to keep up with the literature in 6 subsections of congenital heart disease abstracts on a monthly basis: pediatric cardiology; congenital heart surgery; congenital heart interventions; congenital/pediatric electrophysiology; fetal cardiology; and adult congenital heart disease.
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Dr. Gary Webb, MD and Dr. Mehul Patel
CHiP Network
Congenital Heart and Pediatic Cardiac Journal Watch Editorial Board
The Chip Network, the Congenital Heart International Professionals Network, aims to develop a single global list of all congenital and pediatric cardiac professionals.
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