CHiP Network Congenital Heart Journal Watch – February 2020

Pediatric Cardiology Featured Articles

Pediatric Cardiology Reviews of December 2019 Manuscripts

Neurovascular findings in children and young adults with Loeys-Dietz syndromes: Informing recommendations for screening.

LoPresti MA, Ghali MZ, Srinivasan VM, Morris SA, Kralik SF, Chiou K, Du RY, Lam S.

J Neurol Sci. 2019 Dec 12;409:116633. doi: 10.1016/j.jns.2019.116633. [Epub ahead of print]

PMID: 31862516

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Take Home Points:

  • Cerebrovascular arterial tortuosity is a common finding in patients with Loeys-Dietz syndrome.
  • Neurovascular findings mostly remain stable over years in pediatric patients.

Commentary from Dr. Inga Voges (Kiel, Germany), section editor of Pediatric Cardiology Journal Watch:  The authors retrospectively analysed clinical, genetic and imaging data in children and young adults with Loeys-Dietz syndrome. 47 patients were included of whom 39 had magnetic resonance angiography or computed tomography angiography of the head and neck. 21 patients had follow-up neurovascular imaging; average follow-up was 607 days (range 123–3070 days). Arterial tortuosity index of the left and right internal carotid artery (LICA, RICA) and vertebral arteries (LVA, RVA) were measured (Figure 1). Furthermore, the percent change in Arterial Tortuosity Index over time was calculated.

 

All patients had genetic testing, most common mutations were those in TGFBR2 and TGFBR1. Neurovascular imaging data demonstrated intracranial neurovascular tortuosity in 79.5% and cervical neurovascular tortuosity in 64.1% of patients. Involvement of both, anterior and posterior circulation was common (Table 1). Three patients had intracranial aneurysms. None of the patients had intracranial hemorrhage or vascular rupture and no interventions were performed. Only three patients with follow-up imaging data were subjectively found to have new or progressive anomalies; all of them had a TGFBR2 mutation.

Based on their findings, the authors nicely discuss the frequency of neurovascular screening in pediatric Loeys-Dietz syndrome patients.

 

 

Echocardiographic Assessment of Cardiac Function in Pediatric Survivors of Anthracycline-Treated Childhood Cancer.

Slieker MG, Fackoury C, Slorach C, Hui W, Friedberg MK, Fan CS, Manlhiot C, Dillenburg R, Kantor P, Mital S, Liu P, Nathan PC, Mertens L.

Circ Cardiovasc Imaging. 2019 Dec;12(12):e008869. doi: 10.1161/CIRCIMAGING.119.008869. Epub 2019 Dec 12.

PMID: 31826678

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Take Home Points: 

  • Longitudinal strain is only mildly reduced in pediatric childhood cancer survivors (CCSs) and associated with age at the time of the study and higher body surface area.
  • Left ventricular ejection fraction is preserved in the majority of CCSs.

Commentary from Dr. Inga Voges (Kiel, Germany), section editor of Pediatric Cardiology Journal Watch:  This large multicenter study included 546 pediatric childhood cancer survivors (CCSs)and assessed if echocardiographic strain parameters are of utility for the identification of patients at risk for cardiac dysfunction. Echocardiographic examinations included assessment and calculation of cardiac chamber size, left ventricular (LV) systolic and diastolic function and ventricular mass. Speckle tracking echocardiography was used to measure LV strain parameters. Patients were compared to 134 healthy controls.

The median age and median time from last anthracycline dose were 13.8 years and 7.9 years respectively; all patients were asymptomatic. Compared to controls, CCSs had lower LV ejection fraction (LVEF) and fractional shortening. LV dilatation was only found in 1 patient. Reduced EF with values below 50% were found in 0.8% (n=3) of all patients and 4.2% had values between 51% and 55%. Regarding parameters of diastolic function, the authors found an increased isovolumetric relaxation time in CCS compared to controls.

Global longitudinal strain (GLS) was significantly lower (Figure 1) and circumferential strain (CS) was significantly higher in patients, but the absolute difference was small for both parameters. Lower mean longitudinal strain was associated with lower LVEF in both, patients and controls (Figure 2). Patients with low LS Z-scores had significantly lower CS values.

In multivariable regression analysis age and body surface area were significantly associated with lower mean LS Z-scores. Patients who received a cumulative anthracycline dose of <150 mg/m2 compared to those with a dose >150 mg/m2, there was no difference between patients who received a dose between 150 mg/m2 -300 mg/m2 and those who received a cumulative dose >300 mg/m2.

Overall, the results are interesting, especially for the pediatric cohort of childhood cancer survivors.

Figure 1

Figure 2

 

Safety and Efficacy of Vasopressin After Fontan Completion: A Randomized Pilot Study.

Bigelow AM, Ghanayem NS, Thompson NE, Scott JP, Cassidy LD, Woods KJ, Woods RK, Mitchell ME, Hraŝka V, Hoffman GM.

Ann Thorac Surg. 2019 Dec;108(6):1865-1874. doi: 10.1016/j.athoracsur.2019.06.053. Epub 2019 Aug 7.

PMID: 31400337

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Take Home Points: 

 

  • Vasopressin infusion after Fontan completion was associated with reduced transpulmonary gradient and chest tube drainage in the early postoperative peri.od
  • A larger multi-institutional study will be necessary to confirm safety and to see if this impacts length of stay and is cost-effective.

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch:  While surgical mortality following Fontan palliation is low, postoperative morbidity is common, most often from prolonged pleural fluid drainage. This occurs in 15-40% of patients and is thought to be related to the specific physiologic changes present in the single ventricle population. Many strategies have been attempted to try to reduce chest tube (CT) output with nearly all being unsuccessful on a consistent basis. The authors hypothesized that vasopressin, through its effect on increasing systemic vascular resistance, decreasing capillary leakage, and increasing coronary and pulmonary vasodilation, may be quite suitable in this patient population. This was a small pilot study primarily done to evaluate the safety and efficacy of reducing CT output in a small prospective group of Fontan patients.

This was a randomized, double blinded, placebo controlled trial that included all planned Fontan completions except for those with a history of Fontan takedown, planned AV valvuloplasty, or arch reconstruction, or history of renal replacement therapy. All patients underwent non-fenestrated extracardiac conduit, with standard monitoring and use of inotropes (epinephrine and milrinone) post-operatively. The study drug was initiated at 0.3 mU/kg/min in the OR and continued for 21 hours. It was weaned 0.1 mU/kg/min each hour until discontinued at 24 hours. Additional fluids and titration of inotropes (including open label vasopressin) were at the discretion of the cardiac intensivist. Chest tubes were removed when draining less than 2 ml/kg for 24 hours. 20 patients were studied after a few were excluded or did not consent, with 10 in each group.

There were no differences in the vasopressin and placebo groups in terms of patient characteristics, ventricular morphology, pre-Fontan O2 saturation or hemodynamics, or surgical technique and CPB factors. CT drainage was significantly lower in the vasopressin group during the first postoperative night, POD 1, and at 48 hours after surgery. Median CT duration was 92 hours in the vasopressin group vs 114 hours in the control group. Urine output and fluid balance was similar in both groups. The vasopressin group received significantly higher milrinone dose and had a lower transpulmonary gradient on the first postoperative night. Two patients (one in each arm) received open label vasopressin due to hypotension. Median duration of vasoactive support was the same in both groups. Median hospital stay was 180 hours in the vasopressin group compared to 203 hours in the control group, but this did not meet statistical significance. See table 2, Figure 1, and Table 4.

This was an interesting small single-center RCT that suggests improved transpulmonary gradient and reduced CT output using vasopressin, with no significant safety concerns or deleterious hemodynamic consequences. The vasopressin group did receive a higher dose of milrinone likely due to increased BP; however, the authors think this is likely not a significant confounding variable based on prior studies of milrinone. As a pilot study and as mentioned by the authors, this study was not powered to detect many important clinical outcomes. While CT duration is predicated on CT output, and is likely a main factor in length of hospital stay, statistical significance in this study was not reached. A larger multicenter trial would be recommended.

 

 

Echocardiographic Assessment of Cardiac Function in Pediatric Survivors of Anthracycline-Treated Childhood Cancer.

Slieker MG, Fackoury C, Slorach C, Hui W, Friedberg MK, Fan CS, Manlhiot C, Dillenburg R, Kantor P, Mital S, Liu P, Nathan PC, Mertens L.

Circ Cardiovasc Imaging. 2019 Dec;12(12):e008869. doi: 10.1161/CIRCIMAGING.119.008869. Epub 2019 Dec 12.

PMID: 31826678

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Take Home Points: 

  • Global systolic function and longitudinal strain (LS) are only mildly (and rarely) reduced in childhood cancer survivors (CCS) and most LS values are within the normal range.
  • Simple/isolated LS measurements have a limited value in identifying those at greater risk for later cardiac dysfunction.
  • Circumferential strain, diastolic parameters (TDI), and biomarkers were not significantly different in CCS than the normal population.

 

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch: Early identification of subclinical cardiac/ventricular dysfunction in childhood cancer survivors (CCS) could be very important in allowing clinicians to intervene before full-fledged heart failure develops later in life. Cardiotoxicity from anthracycline chemotherapy is a major cause of long-term morbidity and mortality in CCS. Diagnosis is usually made late, and many studies have shown normal shortening and ejection fraction measurements early in the post-chemo monitoring. Speckle tracking based strain imaging is now recommended in adult patients to help diagnose early, subclinical cardiac function impairment, but has not been well studied in the pediatric population. This was a multicenter study designed to determine the prevalence of cardiac dysfunction in CCS using standard methods of echocardiographic evaluation of cardiac function and speckle tracking strain imaging, to correlate strain values with biomarkers, and to determine risk factors for the presence of abnormal function.

CCS with age of diagnosis < 18, treated with > 1 dose of anthracycline and final dose > 3 years before evaluation, and currently in remission, were included in this study. Exclusions included stem cell transplant, congenital heart defect (except PFO), and familial cardiomyopathy. This study only included those patients ages 4-18, with a control cohort of the same age range. No sedation was used for the echocardiograms and all offline analysis was performed by a single experienced research sonographer. 546 CCS patients were studied at a median age of 13.8 and a median time from last anthracycline dose of 7.9 years. 7 patients were on cardiac medications (2 for reduced EF and 5 for hypertension). The control cohort had 154 patients. The CCS group had a small difference in median age and BSA. 40% of CCS had a cumulative dose of anthracycline < 150 mg/m2, 27% between 150-300 mg/m2, and 13% > 300 mg/m2. 12% received radiation to the chest and 4.5% received dexrazoxane.

Tables 2 shows the conventional echo parameters and table 3 shows the strain and biomarkers for each group. CCS had a statistically lower SF and EF but only 0.8% had an EF < 50%. GLS was also statistically lower in CCS, but the absolute difference was small and a z-score of < -2 was only present in 7.7% compared to 2.4% of the controls. There was no significant relationship with anthracycline dose or use of the cardio-protective agent  dexrazoxane. CCS with an elevated proBNP did not have a lower EF or higher LVEDV compared to controls and was only seen in 4.9%. Only 1.7% of CCS had an elevated hsTnT and this also did not correlate with lower EF or LVEDV. Characteristics associated with a lower LS z-score in CCS on multivariate analysis were only higher age at study and higher BSA (see Table 4).

While this study showed differences in ventricular function, the absolute values were small and most determinants of ventricular function in CCS were within the normal range. This would suggest that single measurements have limited value. The authors noted that their data differs somewhat from the SJLIFE Cohort Study, but this was an older cohort (age 18-65) who more often had chest radiation and higher cumulative doses of anthracyclines. Additionally, biomarkers were not useful in this pediatric population. Perhaps longer term follow up studies will reveal other patterns or changes over time or allow for a creation of a prediction model based on multiple time points.

 

 

 

Pediatric cardiology Dec 2019

 

  1. MicroRNA-204 as an Indicator of Severity of Pulmonary Hypertension in Children with Congenital Heart Disease Complicated with Pulmonary Hypertension.

Li X, Xiang D, Shu Y, Hu K, Zhang Y, Li Y.

Med Sci Monit. 2019 Dec 30;25:10173-10179. doi: 10.12659/MSM.917662.

PMID: 31887731 Free Article

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  1. Trends in the Prevalence of Atrial Septal Defect and Its Associated Factors among Congenital Heart Disease Patients in Vietnam.

Xuan Tuan H, The Phuoc Long P, Duy Kien V, Manh Cuong L, Van Son N, Dalla-Pozza R.

J Cardiovasc Dev Dis. 2019 Dec 27;7(1). pii: E2. doi: 10.3390/jcdd7010002.

PMID: 31892227 Free Article

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  1. The genetics of isolated congenital heart disease.

Nees SN, Chung WK.

Am J Med Genet C Semin Med Genet. 2019 Dec 26. doi: 10.1002/ajmg.c.31763. [Epub ahead of print]

PMID: 31876989

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  1. Impact of prospective measurement of outflow tracts in the prediction of coarctation of the aorta.

Vigneswaran TV, Zidere V, Chivers S, Charakida M, Akolekar R, Simpson JM.

Ultrasound Obstet Gynecol. 2019 Dec 25. doi: 10.1002/uog.21957. [Epub ahead of print]

PMID: 31875324

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  1. Physician Barriers and Facilitators for Screening for Congenital Heart Disease With Routine Obstetric Ultrasound: A National United States Survey.

Pinto NM, Henry KA, Grobman WA, Ness A, Miller S, Ellestad S, Gotteiner N, Tacy T, Wei G, Minich LL, Kinney AY.

J Ultrasound Med. 2019 Dec 24. doi: 10.1002/jum.15199. [Epub ahead of print]

PMID: 31875341

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  1. Genetic Contribution to Congenital Heart Disease (CHD).

Shabana NA, Shahid SU, Irfan U.

Pediatr Cardiol. 2019 Dec 23. doi: 10.1007/s00246-019-02271-4. [Epub ahead of print] Review.

PMID: 31872283

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  1. A novel de novo dominant mutation of NOTCH1 gene in an Iranian family with non-syndromic congenital heart disease.

Kalayinia S, Maleki M, Mahdavi M, Mahdieh N.

J Clin Lab Anal. 2019 Dec 22:e23147. doi: 10.1002/jcla.23147. [Epub ahead of print]

PMID: 31867804

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  1. The Benefits and Bias in Neurodevelopmental Evaluation for Children with Congenital Heart Disease.

Glotzbach KL, Ward JJ, Marietta J, Eckhauser AW, Winter S, Puchalski MD, Miller TA.

Pediatr Cardiol. 2019 Dec 21. doi: 10.1007/s00246-019-02260-7. [Epub ahead of print]

PMID: 31865442

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  1. Novel Measures of Left Ventricular Electromechanical Discoordination Predict Clinical Outcomes in Children with Pulmonary Arterial Hypertension.

Frank B, Schäfer M, Douwes JM, Ivy DD, Abman SH, Davidson JA, Burzlaff S, Mitchell MB, Morgan GJ, Browne L, Barker AJ, Truong U, Von Alvensleben JC.

Am J Physiol Heart Circ Physiol. 2019 Dec 20. doi: 10.1152/ajpheart.00355.2019. [Epub ahead of print]

PMID: 31858817

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  1. Generation of a gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G > A alteration in DAND5.

Inácio JM, Almeida M, Cristo F, Belo JA.

Stem Cell Res. 2019 Dec 20;42:101677. doi: 10.1016/j.scr.2019.101677. [Epub ahead of print]

PMID: 31869685 Free Article

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  1. Three-dimensional and four-dimensional flow assessment in congenital heart disease.

Warmerdam E, Krings GJ, Leiner T, Grotenhuis HB.

Heart. 2019 Dec 19. pii: heartjnl-2019-315797. doi: 10.1136/heartjnl-2019-315797. [Epub ahead of print] Review.

PMID: 31857355

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  1. New Insights into the Impact of Genome-Wide Copy Number Variations on Complex Congenital Heart Disease in Saudi Arabia.

Dasouki MJ, Wakil SM, Al-Harazi O, Alkorashy M, Muiya NP, Andres E, Hagos S, Aldusery H, Dzimiri N, Colak D.

OMICS. 2019 Dec 19. doi: 10.1089/omi.2019.0165. [Epub ahead of print]

PMID: 31855513

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  1. NOD-like receptor protein 3 and high mobility group box-1 are associated with prognosis of patients with congenital heart disease.

Fan J, Qiu Y, Zheng Z, Yu L, Shi S, Wu X.

J Int Med Res. 2019 Dec 18:300060519884500. doi: 10.1177/0300060519884500. [Epub ahead of print] No abstract available.

PMID: 31852352

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  1. Diagnostic accuracy of multi-slice computed tomography in children with Abernethy malformation.

Guo C, Zhong YM, Wang Q, Hu LW, Gu XH, Shao H, Wu W, Cao JF, Qiu HS.

BMC Med Imaging. 2019 Dec 17;19(1):97. doi: 10.1186/s12880-019-0396-3.

PMID: 31847826 Free PMC Article

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  1. The relationship between endothelial progenitor cells and pulmonary arterial hypertension in children with congenital heart disease.

Sun HX, Li GJ, Du ZH, Bing Z, Ji ZX, Luo G, Pan SL.

BMC Pediatr. 2019 Dec 17;19(1):502. doi: 10.1186/s12887-019-1884-x.

PMID: 31847901 Free PMC Article

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  1. Laryngeal Web in the Pediatric Population: Evaluation and Management.

Lawlor CM, Dombrowski ND, Nuss RC, Rahbar R, Choi SS.

Otolaryngol Head Neck Surg. 2019 Dec 17:194599819893985. doi: 10.1177/0194599819893985. [Epub ahead of print]

PMID: 31842676

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  1. Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity.

Frithioff-Bøjsøe C, Lund MAV, Lausten-Thomsen U, Hedley PL, Pedersen O, Christiansen M, Baker JL, Hansen T, Holm JC.

Pediatr Diabetes. 2019 Dec 17. doi: 10.1111/pedi.12964. [Epub ahead of print]

PMID: 31845423

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  1. Use of Sodium Bicarbonate During Pediatric Cardiac Admissions with Cardiac Arrest: Who Gets It and What Does It Do?

Loomba RS, Ahmed M, Abdulkarim M, Villarreal EG, Flores S.

Children (Basel). 2019 Dec 16;6(12). pii: E136. doi: 10.3390/children6120136.

PMID: 31888123 Free Article

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  1. Assessment of quality of life among parents of children with congenital heart disease using WHOQOL-BREF: a cross-sectional study from Northwest Saudi Arabia.

Khoshhal S, Al-Harbi K, Al-Mozainy I, Al-Ghamdi S, Aselan A, Allugmani M, Salem S, El-Agamy D, Abo-Haded H.

Health Qual Life Outcomes. 2019 Dec 16;17(1):183. doi: 10.1186/s12955-019-1249-z.

PMID: 31842888 Free PMC Article

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  1. Lifetime cardiovascular management of patients with previous Kawasaki disease.

Brogan P, Burns JC, Cornish J, Diwakar V, Eleftheriou D, Gordon JB, Gray HH, Johnson TW, Levin M, Malik I, MacCarthy P, McCormack R, Miller O, Tulloh RMR.

Heart. 2019 Dec 16. pii: heartjnl-2019-315925. doi: 10.1136/heartjnl-2019-315925. [Epub ahead of print] Review.

PMID: 31843876 Free Article

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  1. Socioeconomic and racial disparities in the prevalence of congenital heart disease in infants of diabetic mothers.

Chou FS, Chakradhar R, Ghimire LV.

J Matern Fetal Neonatal Med. 2019 Dec 16:1-4. doi: 10.1080/14767058.2019.1702955. [Epub ahead of print]

PMID: 31842654

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  1. Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.

Wünnemann F, Ta-Shma A, Preuss C, Leclerc S, van Vliet PP, Oneglia A, Thibeault M, Nordquist E, Lincoln J, Scharfenberg F, Becker-Pauly C, Hofmann P, Hoff K, Audain E, Kramer HH, Makalowski W, Nir A, Gerety SS, Hurles M, Comes J, Fournier A, Osinska H, Robins J, Pucéat M; MIBAVA Leducq Consortium principal investigators, Elpeleg O, Hitz MP, Andelfinger G.

Nat Genet. 2019 Dec 16. doi: 10.1038/s41588-019-0536-2. [Epub ahead of print]

PMID: 31844321

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  1. Left Ventricular Function, Epicardial Adipose Tissue, and Carotid Intima-Media Thickness in Children and Adolescents With Vertical HIV Infection.

Marsico F, Lo Vecchio A, Paolillo S, DʼAndrea C, De Lucia V, Bruzzese E, Vallone G, Dellegrottaglie S, Marciano C, Trimarco B, Guarino A, Perrone Filardi P.

J Acquir Immune Defic Syndr. 2019 Dec 15;82(5):462-467. doi: 10.1097/QAI.0000000000002158.

PMID: 31714424

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  1. Cardiac manifestations and gene mutations of patients with RASopathies in Taiwan.

Lee CL, Tan LTH, Lin HY, Hwu WL, Lee NC, Chien YH, Chuang CK, Wu MH, Wang JK, Chu SY, Lin JL, Lo FS, Su PH, Hsu CC, Ko YY, Chen MR, Chiu HC, Lin SP.

Am J Med Genet A. 2019 Dec 14. doi: 10.1002/ajmg.a.61429. [Epub ahead of print]

PMID: 31837205

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  1. Spectrum of heart diseases in children presenting to a paediatric cardiac echocardiography clinic in the Lake Zone of Tanzania: a 7 years overview.

Zuechner A, Mhada T, Majani NG, Sharau GG, Mahalu W, Freund MW.

BMC Cardiovasc Disord. 2019 Dec 13;19(1):291. doi: 10.1186/s12872-019-01292-4.

PMID: 31835996 Free PMC Article

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  1. Altered microRNA and target gene expression related to Tetralogy of Fallot.

Grunert M, Appelt S, Dunkel I, Berger F, Sperling SR.

Sci Rep. 2019 Dec 13;9(1):19063. doi: 10.1038/s41598-019-55570-4.

PMID: 31836860 Free PMC Article

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  1. Kindergarten-age neurocognitive, functional, and quality-of-life outcomes after liver transplantation at under 6 years of age.

Joffe AR, Wong K, Bond GY, Khodayari Moez E, Acton BV, Dinu IA, Yap JYK, Robertson CMT; Western Canadian Complex Pediatric Therapies Follow-up Program.

Pediatr Transplant. 2019 Dec 12:e13624. doi: 10.1111/petr.13624. [Epub ahead of print]

PMID: 31833183

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  1. Screening for congenital heart disease in a Singapore neonatal unit.

Ngeow AJ, Tan MG, Choo JT, Tan TH, Tan WC, Chan DK.

Singapore Med J. 2019 Dec 10. doi: 10.11622/smedj.2019167. [Epub ahead of print]

PMID: 31820009 Free Article

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  1. [Clinical and genetic analysis of a child with chromosomal 13q32.1-q33.3 deletion].

Wang H, Huang C, Li L, Liu Y, Wang T, Zhang Y, Li H.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019 Dec 10;36(12):1213-1218. doi: 10.3760/cma.j.issn.1003-9406.2019.12.016. Chinese.

PMID: 31813151

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  1. Current state of home-based exercise interventions in patients with congenital heart disease: a systematic review.

Meyer M, Brudy L, García-Cuenllas L, Hager A, Ewert P, Oberhoffer R, Müller J.

Heart. 2019 Dec 5. pii: heartjnl-2019-315680. doi: 10.1136/heartjnl-2019-315680. [Epub ahead of print] Review.

PMID: 31806699

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  1. The associations between infant development and parenting stress in infants with congenital heart disease at six and twelve months of age.

Golfenshtein N, Hanlon AL, Deatrick JA, Medoff-Cooper B.

J Pediatr Nurs. 2019 Dec 5;51:1-7. doi: 10.1016/j.pedn.2019.11.012. [Epub ahead of print]

PMID: 31812926

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  1. Clinical and postmortem findings of pentalogy of Fallot in an 18-month-old Holstein heifer.

Ishiyama D, Makino E, Nakamura Y, Uchida M, Onodera Y, Chambers JK, Uchida K, Matsuda F.

J Vet Med Sci. 2019 Dec 5;81(11):1676-1679. doi: 10.1292/jvms.19-0147. Epub 2019 Oct 1.

PMID: 31582644 Free PMC Article

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  1. Pulmonary artery pulsatility index predicts prolonged inotrope/pulmonary vasodilator use after implantation of continuous flow left ventricular assist device.

Aggarwal V, Tume SC, Rodriguez M, Adachi I, Cabrera AG, Tunuguntla H, Qureshi AM.

Congenit Heart Dis. 2019 Dec 4. doi: 10.1111/chd.12860. [Epub ahead of print]

PMID: 31802608

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  1. Pentalogy of Fallot: A case report and overview dental implications.

Kaushal D, Kalra N, Tyagi R, Khatri A, Biswas K.

Spec Care Dentist. 2019 Dec 3. doi: 10.1111/scd.12433. [Epub ahead of print]

PMID: 31794068

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  1. Associations of maternal upper respiratory tract infection/influenza during early pregnancy with congenital heart disease in offspring: evidence from a case-control study and meta-analysis.

Xia YQ, Zhao KN, Zhao AD, Zhu JZ, Hong HF, Wang YL, Li SH.

BMC Cardiovasc Disord. 2019 Dec 2;19(1):277. doi: 10.1186/s12872-019-1206-0.

PMID: 31791237 Free PMC Article

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  1. Collaborative caregiving of parents who have an infant with congenital heart disease.

Pridham KF, Harrison TM, Brown R, Mussatto K.

J Spec Pediatr Nurs. 2019 Dec 2:e12283. doi: 10.1111/jspn.12283. [Epub ahead of print]

PMID: 31793183

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  1. Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3.

Kühnisch J, Herbst C, Al-Wakeel-Marquard N, Dartsch J, Holtgrewe M, Baban A, Mearini G, Hardt J, Kolokotronis K, Gerull B, Carrier L, Beule D, Schubert S, Messroghli D, Degener F, Berger F, Klaassen S.

Clin Genet. 2019 Dec;96(6):549-559. doi: 10.1111/cge.13645. Epub 2019 Oct 22.

PMID: 31568572

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  1. Alkylglycerol monooxygenase, a heterotaxy candidate gene, regulates left-right patterning via Wnt signaling.

Duncan AR, González DP, Del Viso F, Robson A, Khokha MK, Griffin JN.

Dev Biol. 2019 Dec 1;456(1):1-7. doi: 10.1016/j.ydbio.2019.07.019. Epub 2019 Aug 6.

PMID: 31398317

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  1. Growing up with a rare genetic disease: an interpretative phenomenological analysis of living with Holt-Oram syndrome.

Brugallé E, Antoine P, Geerts L, Bellengier L, Manouvrier-Hanu S, Fantini-Hauwel C.

Disabil Rehabil. 2019 Dec 1:1-8. doi: 10.1080/09638288.2019.1697763. [Epub ahead of print]

PMID: 31786957

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  1. Mental health care for parents of babies with congenital heart disease during intensive care unit admission: Systematic review and statement of best practice.

Kasparian NA, Kan JM, Sood E, Wray J, Pincus HA, Newburger JW.

Early Hum Dev. 2019 Dec;139:104837. doi: 10.1016/j.earlhumdev.2019.104837. Epub 2019 Aug 24.

PMID: 31455569

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  1. EDUCATIONAL SERIES IN CONGENITAL HEART DISEASE: Echocardiographic assessment of transposition of the great arteries and congenitally corrected transposition of the great arteries

Cohen MS, Mertens LL.

Echo Res Pract. 2019 Dec 1;6(4):R107-R119. doi: 10.1530/ERP-19-0047. Print 2019 Dec 1.

PMID: 31729212 Free PMC Article

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Select item 31326981

 

  1. Advancing Knowledge in Pediatric Heart Failure-the Growing Pains.

Jean-St-Michel E, Marelli A.

J Card Fail. 2019 Dec;25(12):959-960. doi: 10.1016/j.cardfail.2019.10.007. Epub 2019 Oct 23. No abstract available.

PMID: 31655166

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Select item 31626950

 

  1. Left superior pulmonary artery sling.

Wang G, Zhou G.

J Card Surg. 2019 Dec;34(12):1659-1660. doi: 10.1111/jocs.14268. Epub 2019 Sep 26.

PMID: 31557345

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Select item 31646694

 

  1. Developmental Outcome in Infants with Cardiovascular Disease After Cardiopulmonary Resuscitation: A Pilot Study.

Ferentzi H, Pfitzer C, Rosenthal LM, Berger F, Schmitt KRL, Kramer P.

J Clin Psychol Med Settings. 2019 Dec;26(4):575-583. doi: 10.1007/s10880-019-09613-7.

PMID: 30850900

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Select item 30926248

 

  1. Brain injury in congenital heart disease.

Daniels SR.

J Pediatr. 2019 Dec;215:1-3. doi: 10.1016/j.jpeds.2019.10.029. No abstract available.

PMID: 31761128

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Select item 31563274

 

  1. Cohort and Individual Neurodevelopmental Stability between 1 and 6 Years of Age in Children with Congenital Heart Disease.

Naef N, Wehrle F, Rousson V, Latal B.

J Pediatr. 2019 Dec;215:83-89.e2. doi: 10.1016/j.jpeds.2019.08.036. Epub 2019 Sep 25.

PMID: 31563274

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Select item 31561958

 

  1. Human Milk Use in the Preoperative Period Is Associated with a Lower Risk for Necrotizing Enterocolitis in Neonates with Complex Congenital Heart Disease.

Cognata A, Kataria-Hale J, Griffiths P, Maskatia S, Rios D, O’Donnell A, Roddy DJ, Mehollin-Ray A, Hagan J, Placencia J, Hair AB.

J Pediatr. 2019 Dec;215:11-16.e2. doi: 10.1016/j.jpeds.2019.08.009. Epub 2019 Sep 24.

PMID: 31561958

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Select item 31451185

 

  1. Brain Injury in Infants with Critical Congenital Heart Disease: Insights from Two Clinical Cohorts with Different Practice Approaches.

Claessens NHP, Chau V, de Vries LS, Jansen NJG, Au-Young SH, Stegeman R, Blaser S, Shroff M, Haas F, Marini D, Breur JMPJ, Seed M, Benders MJNL, Miller SP.

J Pediatr. 2019 Dec;215:75-82.e2. doi: 10.1016/j.jpeds.2019.07.017. Epub 2019 Aug 23.

PMID: 31451185

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Select item 31488903

 

  1. Early palliative care reduces stress in parents of neonates with congenital heart disease: validation of the “Baby, Attachment, Comfort Interventions”.

Callahan K, Steinwurtzel R, Brumarie L, Schechter S, Parravicini E.

J Perinatol. 2019 Dec;39(12):1640-1647. doi: 10.1038/s41372-019-0490-y. Epub 2019 Sep 5.

PMID: 31488903

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Select item 31434996

 

  1. Delivery room asphyxia in neonates with ductal-dependent congenital heart disease: a retrospective cohort study.

Boos V, Kocjancic L, Berger F, Bührer C.

J Perinatol. 2019 Dec;39(12):1627-1634. doi: 10.1038/s41372-019-0474-y. Epub 2019 Aug 21.

PMID: 31434996

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Select item 31279999

 

  1. Feeding Outcomes in Neonates With Trisomy 21 and Duodenal Atresia.

Smith MD, Landman MP.

J Surg Res. 2019 Dec;244:91-95. doi: 10.1016/j.jss.2019.06.030. Epub 2019 Jul 4.

PMID: 31279999

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Select item 31353104

 

  1. Newborn Screening Pulse Oximetry to Detect Critical Congenital Heart Disease: A Follow-Up Survey of Current Practice at Army, Navy and Air Force Hospitals.

Robinson DL, Craig MS, Wells RS, Liesemer KN, Studer MA.

Mil Med. 2019 Dec 1;184(11-12):826-831. doi: 10.1093/milmed/usz116.

PMID: 31090912

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Select item 27652994

 

  1. Rehabilitation during congenital heart disease in pediatric patients.

Tian J, An X, Niu L.

Minerva Pediatr. 2019 Dec;71(6):533-538. doi: 10.23736/S0026-4946.16.04737-X. Epub 2016 Sep 22.

PMID: 27652994

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Select item 31420818

 

  1. Usefulness of Postnatal Echocardiography in Patients with Down Syndrome with Normal Fetal Echocardiograms.

Cooper A, Sisco K, Backes CH, Dutro M, Seabrook R, Santoro SL, Cua CL.

Pediatr Cardiol. 2019 Dec;40(8):1716-1721. doi: 10.1007/s00246-019-02209-w. Epub 2019 Sep 20.

PMID: 31541264

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Select item 31535184

 

  1. The Limited Benefit of Follow-Up Echocardiograms After Repair of Tetralogy of Fallot.

Xu J, Guthrey C, Dalby S, Tang X, Daily J, Collins RT.

Pediatr Cardiol. 2019 Dec;40(8):1722-1727. doi: 10.1007/s00246-019-02210-3. Epub 2019 Sep 18.

PMID: 31535184

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Select item 31494702

 

  1. What is the Significance of Elevated Troponin I in Children and Adolescents? A Diagnostic Approach.

Yoldaş T, Örün UA.

Pediatr Cardiol. 2019 Dec;40(8):1638-1644. doi: 10.1007/s00246-019-02198-w. Epub 2019 Sep 4.

PMID: 31485699

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Select item 31471627

 

  1. Minimum Travel Distance Among Publicly Insured Infants with Severe Congenital Heart Disease: Potential Impact of In-state Restrictions.

Woo JL, Anderson BR, Gruenstein D, Conti R, Chua KP.

Pediatr Cardiol. 2019 Dec;40(8):1599-1608. doi: 10.1007/s00246-019-02193-1. Epub 2019 Aug 28.

PMID: 31463514

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  1. Myelodysplastic syndrome following a Fontan procedure: A case report.

Keino D, Yokosuka T, Iwasaki F, Hamanoue S, Goto H.

Pediatr Int. 2019 Dec;61(12):1268-1270. doi: 10.1111/ped.14027. No abstract available.

PMID: 31865621

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Select item 31654457

 

  1. Prediction of postnatal clinical course in primary congenital dilated cardiomyopathy.

Yamamoto H, Fukasawa Y, Ohashi N, Yokoyama T, Suzuki K, Ota T, Yasuda K, Omoya K, Takahashi Y, Kato T.

Pediatr Int. 2019 Dec;61(12):1196-1201. doi: 10.1111/ped.14029.

PMID: 31654457

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Select item 31461203

 

  1. Third-generation dual-source dual-energy CT in pediatric congenital heart disease patients: state-of-the-art.

Schicchi N, Fogante M, Esposto Pirani P, Agliata G, Basile MC, Oliva M, Agostini A, Giovagnoni A.

Radiol Med. 2019 Dec;124(12):1238-1252. doi: 10.1007/s11547-019-01097-7. Epub 2019 Oct 19. Review.

PMID: 31630332

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Select item 31833270

 

  1. [Congenital heart disease : fistula from circumflex artery to coronary sinus].

Piette C, Bernard AC, Gach O, Lancellotti P.

Rev Med Liege. 2019 Dec;74(12):625-626. French.

PMID: 31833270

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Select item 31782736

 

  1. Delivery room emergencies in critical congenital heart diseases.

Pruetz JD, Wang SS, Noori S.

Semin Fetal Neonatal Med. 2019 Dec;24(6):101034. doi: 10.1016/j.siny.2019.101034. Epub 2019 Sep 24. Review.

PMID: 31582282

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  1. Taurine treatment of retinal degeneration and cardiomyopathy in a consanguineous family with SLC6A6 taurine transporter deficiency.

Ansar M, Ranza E, Shetty M, Paracha SA, Azam M, Kern I, Iwaszkiewicz J, Farooq O, Pournaras CJ, Malcles A, Kecik M, Rivolta C, Muzaffar W, Qurban A, Ali L, Aggoun Y, Santoni FA, Makrythanasis P, Ahmed J, Qamar R, Sarwar MT, Henry LK, Antonarakis SE.

Hum Mol Genet. 2019 Dec 31. pii: ddz303. doi: 10.1093/hmg/ddz303. [Epub ahead of print]

PMID: 31903486

 

Select item 31906129

 

  1. Ebstein’s anomaly with ‘reversible’ functional pulmonary atresia.

Rato J, R Sousa A, Teixeira A, Anjos R.

BMJ Case Rep. 2019 Dec 29;12(12). pii: e229809. doi: 10.1136/bcr-2019-229809.

PMID: 31888914

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  1. Smartphone interfaced handheld echocardiography for focused assessment of ventricular function and structure in children: A pilot study.

Acheampong B, Parra DA, Aliyu MH, Moon TD, Soslow JH.

Echocardiography. 2019 Dec 27. doi: 10.1111/echo.14575. [Epub ahead of print]

PMID: 31879998

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  1. Takotsubo (stress) cardiomyopathy in childhood.

Topal Y, Topal H, Doğan C, Tiryaki SB, Biteker M.

Eur J Pediatr. 2019 Dec 21. doi: 10.1007/s00431-019-03536-z. [Epub ahead of print]

PMID: 31865427

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  1. Fears and Stressors of Trainees Starting Fellowship in Pediatric Cardiology.

Brown DW, Binney G, Gauthier Z, Blume ED.

Pediatr Cardiol. 2019 Dec 21. doi: 10.1007/s00246-019-02276-z. [Epub ahead of print]

PMID: 31865443

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  1. The Benefits and Bias in Neurodevelopmental Evaluation for Children with Congenital Heart Disease.

Glotzbach KL, Ward JJ, Marietta J, Eckhauser AW, Winter S, Puchalski MD, Miller TA.

Pediatr Cardiol. 2019 Dec 21. doi: 10.1007/s00246-019-02260-7. [Epub ahead of print]

PMID: 31865442

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Select item 31865441

 

  1. Echocardiographic screening for rheumatic heart disease in Turkish school children.

Atalay S, Tutar E, Uçar T, Topçu S, Köse SK, Doğan MT.

Cardiol Young. 2019 Dec 19:1. doi: 10.1017/S1047951119002981. [Epub ahead of print] No abstract available.

PMID: 31854284

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Select item 31856856

 

  1. Three-dimensional and four-dimensional flow assessment in congenital heart disease.

Warmerdam E, Krings GJ, Leiner T, Grotenhuis HB.

Heart. 2019 Dec 19. pii: heartjnl-2019-315797. doi: 10.1136/heartjnl-2019-315797. [Epub ahead of print] Review.

PMID: 31857355

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Select item 31866553

 

71.Anomalous origin of left pulmonary artery from the ascending aorta: echocardiography assessment.

Atmani S, Bendris I.

Cardiol Young. 2019 Dec 16:1-3. doi: 10.1017/S1047951119002804. [Epub ahead of print]

PMID: 31840626

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Select item 31840623

 

  1. Spontaneous closure of muscular ventricular septal defect by growth of right ventricular muscle bundles: a rare mechanism.

Charaf Eddine A, Kadiu G, Sanil Y.

Cardiol Young. 2019 Dec 16:1-3. doi: 10.1017/S1047951119002920. [Epub ahead of print]

PMID: 31840623

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  1. Assessment of quality of life among parents of children with congenital heart disease using WHOQOL-BREF: a cross-sectional study from Northwest Saudi Arabia.

Khoshhal S, Al-Harbi K, Al-Mozainy I, Al-Ghamdi S, Aselan A, Allugmani M, Salem S, El-Agamy D, Abo-Haded H.

Health Qual Life Outcomes. 2019 Dec 16;17(1):183. doi: 10.1186/s12955-019-1249-z.

PMID: 31842888 Free PMC Article

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  1. Atrioventricular canal defect as partial expression of heterotaxia in patients with Bardet-Biedl syndrome.

Digilio MC, Calcagni G, De Luca A, Guida V, Marino B.

J Pediatr. 2019 Dec 13. pii: S0022-3476(19)31461-1. doi: 10.1016/j.jpeds.2019.10.050. [Epub ahead of print] No abstract available.

PMID: 31843215

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Select item 31834463

 

  1. Altered microRNA and target gene expression related to Tetralogy of Fallot.

Grunert M, Appelt S, Dunkel I, Berger F, Sperling SR.

Sci Rep. 2019 Dec 13;9(1):19063. doi: 10.1038/s41598-019-55570-4.

PMID: 31836860 Free PMC Article

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Select item 31829751

 

  1. Neurovascular findings in children and young adults with Loeys-Dietz syndromes: Informing recommendations for screening.

LoPresti MA, Ghali MZ, Srinivasan VM, Morris SA, Kralik SF, Chiou K, Du RY, Lam S.

J Neurol Sci. 2019 Dec 12;409:116633. doi: 10.1016/j.jns.2019.116633. [Epub ahead of print]

PMID: 31862516

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  1. Cardiac arrest in a healthy child due to paradoxical embolus across a previously unrecognised sinus venosus defect.

Samyn MM, Gudausky TM, Kovach JR, Woods RK.

BMJ Case Rep. 2019 Dec 5;12(12). pii: e230135. doi: 10.1136/bcr-2019-230135.

PMID: 31811104

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  1. Effects of oral sildenafil on exercise capacity in children with pulmonary arterial hypertension: a randomised trial.

Russell S, Beghetti M, Oudiz R, Balagtas C, Zhang M, Ivy D.

Open Heart. 2019 Dec 3;6(2):e001149. doi: 10.1136/openhrt-2019-001149. eCollection 2019.

PMID: 31908813

 

Select item 31796981

 

  1. Total absence of the pericardium associated with hypogammaglobulinemia and bronchiectasis in a girl.

Kinuani R, Bruyère PJ, Schoysman L, Kempeneers C, Daron B, Seghaye MC.

Pediatr Rep. 2019 Dec 2;11(4):8250. doi: 10.4081/pr.2019.8250. eCollection 2019 Dec 2.

PMID: 31871606 Free PMC Article

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Select item 31790492

 

  1. Pure Aortic Regurgitation in Pediatric Patients.

Ibrahim A, Borrelli N, Krupickova S, Sabatino J, Avesani M, Paredes J, Josen M, D’Ascenzi F, Mondillo S, Di Salvo G.

Am J Cardiol. 2019 Dec 1;124(11):1731-1735. doi: 10.1016/j.amjcard.2019.08.042. Epub 2019 Sep 9.

PMID: 31586532

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  1. Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus.

Guler Kazanci E, Buyuktiryaki M, Unsal H, Tayman C.

Am J Perinatol. 2019 Dec;36(14):1521-1527. doi: 10.1055/s-0039-1688821. Epub 2019 May 14.

PMID: 31087312

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Select item 31625780

 

 

  1. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy.

Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL.

Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1221-H1230. doi: 10.1152/ajpheart.00409.2019. Epub 2019 Oct 18.

PMID: 31625780

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Select item 31603701

 

  1. A critical appraisal of the tafazzin knockdown mouse model of Barth syndrome: what have we learned about pathogenesis and potential treatments?

Ren M, Miller PC, Schlame M, Phoon CKL.

Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1183-H1193. doi: 10.1152/ajpheart.00504.2019. Epub 2019 Oct 11.

PMID: 31603701

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  1. Safety and Efficacy of Vasopressin After Fontan Completion: A Randomized Pilot Study.

Bigelow AM, Ghanayem NS, Thompson NE, Scott JP, Cassidy LD, Woods KJ, Woods RK, Mitchell ME, Hraŝka V, Hoffman GM.

Ann Thorac Surg. 2019 Dec;108(6):1865-1874. doi: 10.1016/j.athoracsur.2019.06.053. Epub 2019 Aug 7.

PMID: 31400337

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Select item 31398358

 

  1. An unusual presentation of a large cardiac mass.

Cohen MI, Collazo LR, Firan A, Dangol A, Atkins MB.

Cardiol Young. 2019 Dec;29(12):1549-1551. doi: 10.1017/S104795111900249X. Epub 2019 Nov 5.

PMID: 31685077

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Select item 31679548

 

  1. Multimodality cardiovascular imaging in the diagnosis and management of prosthetic valve infective endocarditis in children report of two cases and brief review of the literature.

Chau A, Renella P, Arrieta A.

Cardiol Young. 2019 Dec;29(12):1526-1529. doi: 10.1017/S1047951119002233. Epub 2019 Oct 8.

PMID: 31590699

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  1. Echocardiographic Assessment of Cardiac Function in Pediatric Survivors of Anthracycline-Treated Childhood Cancer.

Slieker MG, Fackoury C, Slorach C, Hui W, Friedberg MK, Fan CS, Manlhiot C, Dillenburg R, Kantor P, Mital S, Liu P, Nathan PC, Mertens L.

Circ Cardiovasc Imaging. 2019 Dec;12(12):e008869. doi: 10.1161/CIRCIMAGING.119.008869. Epub 2019 Dec 12.

PMID: 31826678

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Select item 31766863

 

  1. Impact of Motion Correction Algorithms on Image Quality in Children Undergoing Coronary Computed Tomography Angiography: A Comparison With Regular Monophasic and Multiphasic Acquisitions.

Le Roy J, Zarqane H, Azais B, Vernhet Kovacsik H, Mura T, Okerlund D, Lacampagne A, Amedro P.

Circ Cardiovasc Imaging. 2019 Dec;12(12):e009650. doi: 10.1161/CIRCIMAGING.119.009650. Epub 2019 Nov 26. No abstract available.

PMID: 31766863

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Select item 30632388

 

  1. Right Ventricular-Arterial Coupling Ratio Derived From 3-Dimensional Echocardiography Predicts Outcomes in Pediatric Pulmonary Hypertension.

Jone PN, Schäfer M, Pan Z, Ivy DD.

Circ Cardiovasc Imaging. 2019 Dec;12(1):e008176. doi: 10.1161/CIRCIMAGING.118.008176.

PMID: 30632388

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Select item 31731876

 

  1. Recent advances in our understanding of neurodevelopmental outcomes in congenital heart disease.

White BR, Rogers LS, Kirschen MP.

Curr Opin Pediatr. 2019 Dec;31(6):783-788. doi: 10.1097/MOP.0000000000000829.

PMID: 31693588

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  1. Diuretic Responsiveness and Its Prognostic Significance in Children With Heart Failure.

Price JF, Younan S, Cabrera AG, Denfield SW, Tunuguntla H, Choudhry S, Dreyer WJ, Akcan-Arikan A.

J Card Fail. 2019 Dec;25(12):941-947. doi: 10.1016/j.cardfail.2019.03.019. Epub 2019 Apr 12.

PMID: 30986498

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Select item 31600427

 

  1. Evidence of impaired longitudinal strain in pre-Fontan palliation in functional single left ventricle.

Del Pasqua A, Chinali M, D’Anna C, Ciliberti P, Esposito C, Gugliotta M, Milewski P, Perrone MA, Romeo F, Carotti A, Guccione P, Rinelli G.

J Cardiovasc Med (Hagerstown). 2019 Dec;20(12):833-836. doi: 10.2459/JCM.0000000000000887.

PMID: 31609850

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Select item 31908674

 

  1. Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm.

Tremoulet AH, Jain S, Jone PN, Best BM, Duxbury EH, Franco A, Printz B, Dominguez SR, Heizer H, Anderson MS, Glodé MP, He F, Padilla RL, Shimizu C, Bainto E, Pancheri J, Cohen HJ, Whitin JC, Burns JC.

J Pediatr. 2019 Dec;215:107-117.e12. doi: 10.1016/j.jpeds.2019.07.064. Epub 2019 Sep 24.

PMID: 31561960

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Select item 31451185

 

  1. Brain Injury in Infants with Critical Congenital Heart Disease: Insights from Two Clinical Cohorts with Different Practice Approaches.

Claessens NHP, Chau V, de Vries LS, Jansen NJG, Au-Young SH, Stegeman R, Blaser S, Shroff M, Haas F, Marini D, Breur JMPJ, Seed M, Benders MJNL, Miller SP.

J Pediatr. 2019 Dec;215:75-82.e2. doi: 10.1016/j.jpeds.2019.07.017. Epub 2019 Aug 23.

PMID: 31451185

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Select item 31673462

 

  1. Cardiac Autonomic Function in the First Hours of Postnatal Life: An Observational Cross-Sectional Study in Term Neonates.

Shayani LA, da Cruz CJ, Porto LGG, Molina GE.

Pediatr Cardiol. 2019 Dec;40(8):1703-1708. doi: 10.1007/s00246-019-02207-y. Epub 2019 Sep 16.

PMID: 31529226

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Select item 31520096

 

  1. Double Orifice Mitral Valve in Tricuspid Atresia: A Rare Association.

Cantinotti M, Giordano R, Marrone C, Franchi E, Koestenberger M, Assanta N.

Pediatr Cardiol. 2019 Dec;40(8):1761-1762. doi: 10.1007/s00246-019-02204-1. Epub 2019 Sep 10.

PMID: 31506732

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Select item 31506731

 

  1. What is the Significance of Elevated Troponin I in Children and Adolescents? A Diagnostic Approach.

Yoldaş T, Örün UA.

Pediatr Cardiol. 2019 Dec;40(8):1638-1644. doi: 10.1007/s00246-019-02198-w. Epub 2019 Sep 4.

PMID: 31485699

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Select item 31482237

 

  1. Early Neurodevelopmental Outcomes in Children with Hypoplastic Left Heart Syndrome and Related Anomalies After Hybrid Procedure.

Khalid OM, Harrison TM.

Pediatr Cardiol. 2019 Dec;40(8):1591-1598. doi: 10.1007/s00246-019-02191-3. Epub 2019 Aug 30.

PMID: 31471627

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Select item 31471626

 

  1. Risk Factors for Prolonged Pleural Effusion After Extracardiac Fontan Operation.

Kim G, Ko H, Byun JH, Lee HD, Kim H, Sung SC, Choi KH.

Pediatr Cardiol. 2019 Dec;40(8):1545-1552. doi: 10.1007/s00246-019-02183-3. Epub 2019 Aug 21.

PMID: 31435694

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Select item 31367951

 

  1. The long-term outcome of an isolated vascular ring – A single-center experience.

Depypere A, Proesmans M, Cools B, Vermeulen F, Daenen W, Meyns B, Rega F, Boon M.

Pediatr Pulmonol. 2019 Dec;54(12):2028-2034. doi: 10.1002/ppul.24490. Epub 2019 Aug 27.

PMID: 31456344

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Select item 31424175

 

  1. Persistent right umbilical vein in isomerism.

Acherman RJ, Evans WN.

Prenat Diagn. 2019 Dec;39(13):1220-1224. doi: 10.1002/pd.5571. Epub 2019 Nov 13.

PMID: 31600425

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Select item 31600411

 

 

ACHD Featured Articles in association with ISACHD

Adult Congenital Heart Featured Reviews of December 2019 Abstracts provided through collaboration with ISACHD.

 Over 25 Years of Experience with the Ross Procedure in Children: A Single-Centre Experience.

Martin E, Laurin C, Jacques F, Houde C, Cote JM, Chetaille P, Drolet C, Vaujois L, Kalavrouziotis D, Mohammadi S, Perron J.

Ann Thorac Surg. 2019 Dec 24. pii: S0003-4975(19)31919-8. doi: 10.1016/j.athoracsur.2019.10.093. [Epub ahead of print]

PMID: 31881194

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Select item 31874649

Take Home Points:

  • This study boasts the longest and most complete dataset for people treated with a Ross procedure.
  • Mortality in the early post-operative period is low.
  • Paediatric Ross survival has good long term survival: 96.7% at 5 years and 94.4% at 25 years.
  • Ross related re-interventions was twice as common for the pulmonary homograft than for the autograft.
  • Freedom from autograft-related intervention was 98.1% at 5 years and 61.2% at 25 years.
  • Freedom from pulmonary conduit re-intervention was 93.2% at 5 years and 28.3% at 25 years.

Commentary from Dr. Blanche Cupido (Cape Town, South Africa), section editor of ACHD Journal Watch:  In children, all available surgical options for aortic valve prostheses pose limitations. Both surgical repair techniques and balloon valvuloplasty are utilized to postpone valve replacement when possible. Though the Ross procedure is technically rather complex, it is a valuable and good option as aortic valve replacement in children. Re-intervention of the autograft and the pulmonary conduit have frequently been described and may impact longevity.

This single center study described the long term clinical and echocardiographic outcomes following the Ross procedure in children at a tertiary referral center in Canada. It is a retrospective review of consecutive children (under age 18) who underwent a Ross procedure between January 1990 and January 2018 – a total of 25 years’ experience with this procedure. Clinical, surgical and echocardiographic data was reviewed.

The primary outcome was in-hospital and long term survival. Long term valve-related outcomes and Ross-related interventions were also reviewed. Fifty-two percent of patients were followed up for > 20 years. Clinical data spanned 1019 person-years and echocardiographic data 977 person-years. Patients post-Ross procedure were followed up annually.

A total of 63 patients underwent the Ross procedure. (81% of this cohort was male). Fifty-four percent (n=34) of patients, had one or more open surgical procedure prior to the Ross procedure.  51% had previous surgical aortic valvuloplasty and 22% had previous percutaneous balloon valvuloplasty. On average, the Ross procedure happened 4.6 years after these procedures. Isolated aortic stenosis was the pathology in 46% of patients. In 10% of patients, the surgery was urgent, it was semi-elective in 31% and elective in 59%.

One patient died in the peri-operative period (1.6%). 6% of patients (n=4) required re-exploration for mediastinal bleeding. None required ECMO support. None developed in-hospital pulmonary autograft or homograft failure. Table 3 below shows the immediate post-operative outcomes:

 

Two non-Ross related cardiac deaths occurred at 3.5 and 10.4 years post-Ross procedure respectively. Figure 1 below shows an overall survival of 98.4%, 94.4% and 94.4% at 1, 15 and 25 years respectively.

 

Pulmonary autograft degeneration occurred in 19 patients (30%). None developed pulmonary stenosis. Fifteen of these patients had an autograft re-operation at a median of 15.9 years post-Ross procedure. Ten of these 15 patients, underwent autograft root-sparing procedure (David procedure). The other 5 had a Bentall procedure. No mortality was associated with re-operation.  Freedom from pulmonary autograft reoperation was 100% at 1 year, 86.4% at 15 years and 61.2% at 25 years (see figure 2 below):

 

 

Forty-nine (n=31) percent of patients developed degeneration of the pulmonary homograft with 23 patients undergoing re-intervention at a median of 11.1 years. Thirteen patients had pulmonary stenosis, 10 had pulmonary incompetence and 8 had a combination of the above lesions. Freedom from any homograft re-intervention was 96.7 % at 1 year, 58.2% at 15 years and 28.3% at 25 years: See figure 3 below)

In total, 63% (n=40) patients developed a Ross-related failure around 12 years post-procedure. Of these, 31 patients had re-intervention on pulmonary conduit or pulmonary homograft at 11.9 years. At 1 and 25 years respectively, the freedom from a Ross related intervention (both surgical and percutaneous) was 96.7% and 26.3%. (see figure 4 below):

 

Six percent (n=4) developed infective endocarditis de novo.

 

 

 

Eccentric Enlargement of the Aortic Sinuses in Pediatric and Adult Patients with Bicuspid Aortic Valves: A Cardiac MRI Study.

Stefek HA, Lin KH, Rigsby CK, Michelena HI, Aouad P, Barker AJ, Robinson JD.

Pediatr Cardiol. 2019 Dec 19. doi: 10.1007/s00246-019-02264-3. [Epub ahead of print]

PMID: 31858201

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Take Home Points: 

  • In patients with a bicuspid aortic valve (BAV), root size and cusp fusion pattern is associated with disease outcomes
  • This retrospective study characterised aortic sinus symmetry in adult and paediatric patients with a BAV and association to valvulopathy and aortopathy.
  • Using CMR studies, 149 adults and 51 children with BAV were characterised and compared to 40 adults and 20 children with normal aortic valve morphology.
  • In both adults and children with a BAV, the non-fused aortic sinus was larger than either fused sinus.
  • Sinus eccentricity in BAV patients was significantly greater than in patients with a normal aortic valve.
  • Degree of eccentricity varies with valve dysfunction and BAV phenotype but, does not relate to degree of aortic root dilation.
  • In adults, degree of eccentricity does not correlate with ascending aortic dilation.

 

Commentary from Dr. Damien Cullington (Liverpool, UK), section editor of ACHD Journal Watch: 

The BAV is the commonest congenital cardiac lesion and seen in approximately 0.5%-2% of the

population. Congenital cardiologists will frequently encounter the patients with the long-term consequences of BAV – namely, aortic stenosis, aortic regurgitation, a combination of both with and without an aortopathy. It is challenging to predict disease progression in the individual patient. Valves with fusion of right-left coronary cusps are more likely to develop AI whilst valves with fusion of right and non-coronary cusps are more likely to develop stenosis. Furthermore, aortopathy is influenced by different BAV phenotypes, probably due to the eccentricity of the outflow jet through the BAV.

A flowchart showing the process for patient selection is shown in Figure 1. Of the adult patients with a BAV (n=149) the mean age was 48 years old. Of the paediatric patients with BAV (n=51), the mean age was 15 years old. The demographics of patients with BAV phenotype and aortic valve disease and aortopathy is shown in Table 1.

 

Figure 1. Flowchart of inclusion and exclusion criteria used in formation of paediatric and adult study cohorts (CMR cardiac MRI, AAo ascending aorta, RL BAV with right-left cusp fusion, RN BAV with right-non coronary cusp fusion)

Table 1. Patient demographics in BAV and normal aortic valve cohorts

 

Conclusions 

This study showed that patients with BAV exhibit significant sinus asymmetry characterised by preferential non-fused sinus dominance. Eccentricity is seen in both adults and children – it isn’t associated with age suggesting possible genetic pre-disposition. In this small study, there was no statistically significant difference in degree of eccentricity of the aortic root in either adults or children with RL or RN cusp fusion. Larger observational studies are required.

 

Relation Between Exercise Capacity and Extracardiac Conduit Size in Patients with Fontan Circulation.

Lee SY, Song MK, Kim GB, Bae EJ, Kim SH, Jang SI, Cho SK, Kawk JG, Kim WH, Lee CH, Kim HJ, Kim J.

Pediatr Cardiol. 2019 Dec;40(8):1584-1590. doi: 10.1007/s00246-019-02190-4. Epub 2019 Aug 31.

PMID: 31473799

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Select item 31471627

Take Home Points: 

  • Conduit size is one of the determinants of preload in an extracardiac Fontan circuit.
  • Its affect onto exercise capacity is independent of gender, age of Fontan operation, ventricular morphology, isomerism and the presence of fenestration in the Fontan circuit.
  • Patients in the study demonstrated highest exercise capacity when the conduit size is 12.5mm/m2
  • Based on the calculation above, the optimum conduit size should be 16-18mm.

Commentary from Dr. MC Leong (Kuala Lumpur), section editor of ACHD Journal Watch:  In extracardiac Fontan, the conduit size is one of the key factors that determines the preload to the Fontan circuit. Larger conduit may cause flow energy loss and increase the risk of thrombosis due to stagnation of blood flow. Meanwhile, smaller conduit may increase the flow resistance. In this study, the authors sought to determine the optimal size of extracardiac Fontan conduit by comparing exercise capacity with each conduit size to see which yielded the best exercise capacity.

150 patients (male: female = 97:53; mean age :17.5 ± 5.1 years) who had undergone extracardiac Fontan completion was retrospectively reviewed. All these patients underwent cardiopulmonary exercise with expiratory gas analysis using Bruce protocol. Invasively measured central venous pressure was 12.4 ± 2.5mmHg while the pulmonary vascular resistance was 1.2 ± 0.5 Woods unit. Non-linear association between conduit diameter per body surface area (BSA) and predicted peak VO2 was computed. The authors found maximum peak VO2 at about 12.7mm/m2 conduit diameter. VE/VCO2 was lowest at 12.4mm/m2 conduit diameter and that patients had maximum exercise capacity when the conduit diameter is 12.5mm/m2 (Figure 1). This was not affected by gender, the age of Fontan operation, ventricular morphology, isomerism and the presence of fenestration in the Fontan circuit (Table 3).

The authors found that conduit size 16 and 18mm to be optimal, taking into account that a body surface area of 1.57m2 in a normal adult (1.57 x 12.5mm). They also noted that although 16mm and 24mm conduit are 4mm different from a 20mm conduit in terms of diameter, the area difference is not proportional to the difference in the diameter change (Figure 2). Area difference is less if a smaller conduit is used. The authors, therefore cautioned the use of bigger conduits when fashioning the extracardiac Fontan circuit.

Often, surgeons prefer a larger conduit over a smaller one to give allowance for growth. Unfortunately, such a decision may lead to a poorer exercise capacity, which presumably due to a higher flow energy loss and a lower preload. This paper has elegantly demonstrated so.

 

 

ACHD Dec 2019

 

  1. Systematic Evaluation of Systemic Right Ventricular Function.

Schneider M, Beichl M, Nietsche C, Beitzke D, Porenta G, Beran G, Vonbank K, Hauser J, Hengstenberg C, Goliasch G, Binder T, Gabriel H.

J Clin Med. 2019 Dec 31;9(1). pii: E107. doi: 10.3390/jcm9010107.

PMID: 31906129

 

Select item 31895976

 

  1. Changes in left and right ventricular longitudinal function after pulmonary valve replacement in patients with Tetralogy of Fallot.

Sjöberg P MD, Ostenfeld E, Hedström E, Arheden H, Gustafsson R, Nozohoor S, Carlsson M.

Am J Physiol Heart Circ Physiol. 2019 Dec 30. doi: 10.1152/ajpheart.00417.2019. [Epub ahead of print]

PMID: 31886724

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  1. Ascending aortic dissection in a pregnant patient with neonatally repaired coarctation of aorta and bicuspid aortic valve.

Cassar MP, Shabbir A, Orchard E, Stirrup J.

BMJ Case Rep. 2019 Dec 29;12(12). pii: e233367. doi: 10.1136/bcr-2019-233367.

PMID: 31888910

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Select item 31892227

 

  1. Growth differentiation factor 15 as a useful biomarker of heart failure in young patients with unrepaired congenital heart disease of left to right shunt.

Kagiyama Y, Yatsuga S, Kinoshita M, Koteda Y, Kishimoto S, Koga Y, Suda K.

J Cardiol. 2019 Dec 26. pii: S0914-5087(19)30382-X. doi: 10.1016/j.jjcc.2019.12.008. [Epub ahead of print]

PMID: 31883956

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  1. Creating a maternal cardiac center of excellence: a call to action.

Daming TNB, Florio KL, Schmidt LM, Grodzinsky A, Nelson LA, Swearingen KC, White DL, Patel NB, Gray RA, Rader VJ, Lee JK, Spertus JA, Magalski A.

J Matern Fetal Neonatal Med. 2019 Dec 25:1-6. doi: 10.1080/14767058.2019.1706474. [Epub ahead of print]

PMID: 31875732

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Select item 31875324

 

  1. Heart failure with reduced and preserved ejection fraction in adult congenital heart disease.

Vaikunth SS, Lui GK.

Heart Fail Rev. 2019 Dec 24. doi: 10.1007/s10741-019-09904-z. [Epub ahead of print] Review.

PMID: 31873841

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Select item 31883903

 

  1. Highlights of the fourteenth annual scientific meeting of the Society of Cardiovascular Computed Tomography.

Weir-McCall JR, Nicol E, Abbara S, Branch K, Choi AD, Ghoshhajra BB, Leipsic J, Nieman K, Shaw LJ, Blankstein R.

J Cardiovasc Comput Tomogr. 2019 Dec 24. pii: S1934-5925(19)30751-8. doi: 10.1016/j.jcct.2019.12.034. [Epub ahead of print]

PMID: 31883903

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Select item 31875341

 

  1. Trans-Right-Ventricle and Transpulmonary MicroRNA Gradients in Human Pulmonary Arterial Hypertension.

Chouvarine P, Geldner J, Giagnorio R, Legchenko E, Bertram H, Hansmann G.

Pediatr Crit Care Med. 2019 Dec 24. doi: 10.1097/PCC.0000000000002207. [Epub ahead of print]

PMID: 31876555

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Select item 31868314

 

  1. Mechanisms for heart failure in systemic right ventricle.

Andrade L, Carazo M, Wu F, Kim Y, Wilson W.

Heart Fail Rev. 2019 Dec 19. doi: 10.1007/s10741-019-09902-1. [Epub ahead of print] Review.

PMID: 31853794

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Select item 31856879

 

  1. Liver Strain Using Feature Tracking of Cine Cardiac Magnetic Resonance Imaging: Assessment of Liver Dysfunction in Patients with Fontan Circulation and Tetralogy of Fallot.

Ohashi R, Nagao M, Ishizaki U, Shiina Y, Inai K, Sakai S.

Pediatr Cardiol. 2019 Dec 18. doi: 10.1007/s00246-019-02272-3. [Epub ahead of print]

PMID: 31853582

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Select item 31427066

 

  1. Fontan-associated liver disease: pathophysiology, investigations, predictors of severity and management.

Keung CY, Zentner D, Gibson RN, Phan DH, Grigg LE, Sood S, Nicoll AJ.

Eur J Gastroenterol Hepatol. 2019 Dec 16. doi: 10.1097/MEG.0000000000001641. [Epub ahead of print]

PMID: 31851099

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Select item 31842888

 

  1. Altered frontal white matter microstructure is associated with working memory impairments in adolescents with congenital heart disease: A diffusion tensor imaging study.

Ehrler M, Latal B, Kretschmar O, von Rhein M, O’Gorman Tuura R.

Neuroimage Clin. 2019 Dec 16;25:102123. doi: 10.1016/j.nicl.2019.102123. [Epub ahead of print]

PMID: 31869770 Free PMC Article

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Select item 31844927

 

  1. Pregnancy outcomes in women with cardiovascular disease: evolving trends over 10 years in the ESC Registry Of Pregnancy And Cardiac disease (ROPAC).

Roos-Hesselink J, Baris L, Johnson M, De Backer J, Otto C, Marelli A, Jondeau G, Budts W, Grewal J, Sliwa K, Parsonage W, Maggioni AP, van Hagen I, Vahanian A, Tavazzi L, Elkayam U, Boersma E, Hall R.

Eur Heart J. 2019 Dec 14;40(47):3848-3855. doi: 10.1093/eurheartj/ehz136.

PMID: 30907409

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Select item 31859238

 

  1. Left circumflex coronary artery originating from the pulmonary artery (LCx-ALCAPA) in an adult woman after VSD closure and ICD implantation.

Borowiec K, Biernacka EK, Kępka C, Woźniak O, Wnuk J, Teresińska A, Hoffman P.

J Cardiovasc Comput Tomogr. 2019 Dec 14. pii: S1934-5925(19)30405-8. doi: 10.1016/j.jcct.2019.11.008. [Epub ahead of print] No abstract available.

PMID: 31859238

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Select item 31833661

 

  1. The genetic workup for structural congenital heart disease.

Jerves T, Beaton A, Kruszka P.

Am J Med Genet C Semin Med Genet. 2019 Dec 13. doi: 10.1002/ajmg.c.31759. [Epub ahead of print]

PMID: 31833661

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Select item 31835996

 

  1. Aortic elasticity after aortic coarctation relief: comparison of surgical and interventional therapy by cardiovascular magnetic resonance imaging.

Pieper T, Latus H, Schranz D, Kreuder J, Reich B, Gummel K, Hudel H, Voges I.

BMC Cardiovasc Disord. 2019 Dec 12;19(1):286. doi: 10.1186/s12872-019-01270-w.

PMID: 31830907 Free PMC Article

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Select item 31891904

 

  1. An extensible software platform for interdisciplinary cardiovascular imaging research.

Huellebrand M, Messroghli D, Tautz L, Kuehne T, Hennemuth A.

Comput Methods Programs Biomed. 2019 Dec 12;184:105277. doi: 10.1016/j.cmpb.2019.105277. [Epub ahead of print]

PMID: 31891904

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Select item 31829751

 

  1. Features of Marfan syndrome not listed in the Ghent nosology – The Dark Side of the Disease.

von Kodolitsch Y, Demolder A, Girdauskas E, Kaemmerer H, Kornhuber K, Muino Mosquera L, Morris S, Neptune E, Pyeritz R, Rand-Hendriksen S, Rahman A, Riise N, Robert L, Staufenbiel I, Szöcs K, Vanem TT, Linke SJ, Vogler M, Yetman A, De Backer J.

Expert Rev Cardiovasc Ther. 2019 Dec 12. doi: 10.1080/14779072.2019.1704625. [Epub ahead of print]

PMID: 31829751

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Select item 31831077

 

  1. Long term CMR follow up of patients with right ventricular abnormality and clinically suspected arrhythmogenic right ventricular cardiomyopathy (ARVC).

Femia G, Semsarian C, McGuire M, Sy RW, Puranik R.

J Cardiovasc Magn Reson. 2019 Dec 12;21(1):76. doi: 10.1186/s12968-019-0581-0.

PMID: 31831077 Free PMC Article

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Select item 31791182

 

  1. Pregnancy outcomes among 31 patients with tetralogy of Fallot, a retrospective study.

Wang K, Xin J, Wang X, Yu H, Liu X.

BMC Pregnancy Childbirth. 2019 Dec 10;19(1):486. doi: 10.1186/s12884-019-2630-y.

PMID: 31823779 Free PMC Article

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Select item 31821461

 

  1. EuroCMR 2019 highlights.

Rodriguez-Palomares JF, Edvardsen T, Almeida AG, Petersen SE.

Eur Heart J Cardiovasc Imaging. 2019 Dec 10. pii: jez307. doi: 10.1093/ehjci/jez307. [Epub ahead of print]

PMID: 31821461

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Select item 31821450

 

  1. Left superior vena cava: cross-sectional imaging overview.

Batouty NM, Sobh DM, Gadelhak B, Sobh HM, Mahmoud W, Tawfik AM.

Radiol Med. 2019 Dec 10. doi: 10.1007/s11547-019-01114-9. [Epub ahead of print] Review.

PMID: 31823296

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Select item 31820009

 

  1. Assessing Pregnancy, Gestational Complications, and Co-morbidities in Women With Congenital Heart Defects (Data from ICD-9-CM Codes in 3 US Surveillance Sites).

Raskind-Hood C, Saraf A, Riehle-Colarusso T, Glidewell J, Gurvitz M, Dunn JE, Lui GK, Van Zutphen A, McGarry C, Hogue CJ, Hoffman T, Rodriguez Iii FH, Book WM.

Am J Cardiol. 2019 Dec 9. pii: S0002-9149(19)31347-5. doi: 10.1016/j.amjcard.2019.12.001. [Epub ahead of print]

PMID: 31902476

 

Select item 31818859

 

  1. Echocardiography vs cardiac magnetic resonance imaging assessment of the systemic right ventricle for patients with d-transposition of the great arteries status post atrial switch.

Samyn MM, Yan K, Masterson C, Goot BH, Saudek D, Lavoie J, Kinney A, Krolikowski M, Hor K, Cohen S.

Congenit Heart Dis. 2019 Dec 9. doi: 10.1111/chd.12861. [Epub ahead of print]

PMID: 31816182

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Select item 31813956

 

  1. Interventions to Bring Comprehensive Care to People with Chagas Disease: Experiences in Bolivia, Argentina and Colombia.

Pinazo MJ, Pereiro A, Herazo R, Chopita M, Forsyth C, Lenardon M, Losada I, Torrico F, Marchiol A, Vera M.

Acta Trop. 2019 Dec 4:105290. doi: 10.1016/j.actatropica.2019.105290. [Epub ahead of print] Review.

PMID: 31811865 Free Article

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Select item 31801789

 

  1. Angiopoietin-2 predicts morbidity in adults with Fontan physiology.

Shirali AS, Lluri G, Guihard PJ, Conrad MB, Kim H, Pawlikowska L, Boström KI, Iruela-Arispe ML, Aboulhosn JA.

Sci Rep. 2019 Dec 4;9(1):18328. doi: 10.1038/s41598-019-54776-w.

PMID: 31797976 Free PMC Article

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Select item 31779794

 

  1. Quality Improvement Through Data Registries: Sharing Is Caring.

Bhatt AB, Krishnamurthy Y.

J Am Coll Cardiol. 2019 Dec 3;74(22):2796-2798. doi: 10.1016/j.jacc.2019.10.023. No abstract available.

PMID: 31779794

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Select item 31793037

 

  1. Neopulmonary Outflow Tract Obstruction Assessment by 4D Flow MRI in Adults With Transposition of the Great Arteries After Arterial Switch Operation.

Belhadjer Z, Soulat G, Ladouceur M, Pitocco F, Legendre A, Bonnet D, Iserin L, Mousseaux E.

J Magn Reson Imaging. 2019 Dec 3. doi: 10.1002/jmri.27012. [Epub ahead of print]

PMID: 31794141

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Select item 31838031

 

  1. Advanced Heart Failure in Adults With Congenital Heart Disease.

Menachem JN, Schlendorf KH, Mazurek JA, Bichell DP, Brinkley DM, Frischhertz BP, Mettler BA, Shah AS, Zalawadiya S, Book W, Lindenfeld J.

JACC Heart Fail. 2019 Dec 3. pii: S2213-1779(19)30729-2. doi: 10.1016/j.jchf.2019.08.012. [Epub ahead of print] Review.

PMID: 31838031

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Select item 31794068

 

  1. Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: Detecting subclinical kidney injury.

Fuhrman DY, Nguyen L, Hindes M, Kellum JA.

Congenit Heart Dis. 2019 Dec 2. doi: 10.1111/chd.12862. [Epub ahead of print]

PMID: 31793232

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Select item 31800741

 

  1. Congenital nystagmus, disability, visual impairment, and noncompaction suggest hereditary disease.

Finsterer J.

Einstein (Sao Paulo). 2019 Dec 2;17(4):eCE5251. doi: 10.31744/einstein_journal/2019CE5251. English, Portuguese. No abstract available.

PMID: 31800741 Free PMC Article

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Select item 31819672

 

  1. Prevalence of unsuspected abnormal echocardiograms in adolescents with down syndrome.

Clauss SB, Gidding SS, Cochrane CI, Walega R, Zemel BS, Pipan ME, Magge SN, Kelly A, Cohen MS.

Am J Med Genet A. 2019 Dec;179(12):2420-2424. doi: 10.1002/ajmg.a.61367. Epub 2019 Oct 6.

PMID: 31588666

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Select item 29351431

 

  1. Heart Failure in Adult Patients with Congenital Heart Disease.

Smit-Fun VM, Buhre WF.

Anesthesiol Clin. 2019 Dec;37(4):751-768. doi: 10.1016/j.anclin.2019.08.005. Epub 2019 Sep 27. Review.

PMID: 31677689

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Select item 31398358

 

  1. Pregnancy in Women with Complex Congenital Heart Disease. A Constant Challenge.

Avila WS, Ribeiro VM, Rossi EG, Binotto MA, Bortolotto MR, Testa C, Francisco R, Hajjar LA, Miura N.

Arq Bras Cardiol. 2019 Dec;113(6):1062-1069. doi: 10.5935/abc.20190197. English, Portuguese.

PMID: 31596322 Free Article

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Select item 31813510

 

  1. Prevalence and Effects of Cigarette Smoking, Cannabis Consumption, and Co-use in Adults From 15 Countries With Congenital Heart Disease.

Moons P, Luyckx K, Kovacs AH, Holbein CE, Thomet C, Budts W, Enomoto J, Sluman MA, Yang HL, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Apers S; APPROACH-IS Consortium and the International Society for Adult Congenital Heart Disease (ISACHD).

Can J Cardiol. 2019 Dec;35(12):1842-1850. doi: 10.1016/j.cjca.2019.07.635. Epub 2019 Aug 14.

PMID: 31813510

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Select item 31813508

 

  1. Cancer Risk in Congenital Heart Disease-What Is the Evidence?

Cohen S, Gurvitz MZ, Beauséjour-Ladouceur V, Lawler PR, Therrien J, Marelli AJ.

Can J Cardiol. 2019 Dec;35(12):1750-1761. doi: 10.1016/j.cjca.2019.09.023. Epub 2019 Oct 9. Review.

PMID: 31813507

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Select item 31813506

 

  1. Heart Failure in Adult Congenital Heart Disease: From Advanced Therapies to End-of-Life Care.

Crossland DS, Van De Bruaene A, Silversides CK, Hickey EJ, Roche SL.

Can J Cardiol. 2019 Dec;35(12):1723-1739. doi: 10.1016/j.cjca.2019.07.626. Epub 2019 Jul 26. Review.

PMID: 31813505

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Select item 31813504

 

  1. Eisenmenger Syndrome: A Multisystem Disorder-Do Not Destabilize the Balanced but Fragile Physiology.

Chaix MA, Gatzoulis MA, Diller GP, Khairy P, Oechslin EN.

Can J Cardiol. 2019 Dec;35(12):1664-1674. doi: 10.1016/j.cjca.2019.10.002. Epub 2019 Oct 10. Review.

PMID: 31813503

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Select item 31813502

 

  1. Congenital Heart Disease and Women’s Health Across the Life Span: Focus on Reproductive Issues.

Haberer K, Silversides CK.

Can J Cardiol. 2019 Dec;35(12):1652-1663. doi: 10.1016/j.cjca.2019.10.009. Epub 2019 Oct 16. Review.

PMID: 31813502

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Select item 31813501

 

  1. Transition and Transfer From Pediatric to Adult Congenital Heart Disease Care in Canada: Call For Strategic Implementation.

Mackie AS, Fournier A, Swan L, Marelli AJ, Kovacs AH.

Can J Cardiol. 2019 Dec;35(12):1640-1651. doi: 10.1016/j.cjca.2019.08.014. Epub 2019 Aug 22. Review.

PMID: 31813501

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Select item 31813500

 

  1. Misperception of Survival in Adult Congenital Heart Disease and Importance of Both Anatomic and Functional Indices: Educate Your Patients!

Wichert-Schmitt B, Oechslin E.

Can J Cardiol. 2019 Dec;35(12):1635-1639. doi: 10.1016/j.cjca.2019.08.027. Epub 2019 Aug 27. No abstract available.

PMID: 31813500

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Select item 31813496

 

  1. The Future of Adult Congenital Heart Disease Research: Precision Health Services Delivery for the Next Decade.

Marelli A.

Can J Cardiol. 2019 Dec;35(12):1609-1619. doi: 10.1016/j.cjca.2019.09.015. Epub 2019 Sep 28. No abstract available.

PMID: 31813496

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Select item 31711822

 

  1. Non-Vitamin K Antagonist Oral Anticoagulants in Adult Congenital Heart Disease.

Mongeon FP, Macle L, Beauchesne LM, Bouma BJ, Schwerzmann M, Mulder BJM, Khairy P.

Can J Cardiol. 2019 Dec;35(12):1686-1697. doi: 10.1016/j.cjca.2019.06.022. Epub 2019 Jun 26. Review.

PMID: 31635950

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Select item 31570238

 

  1. Neurocognition in Adult Congenital Heart Disease: How to Monitor and Prevent Progressive Decline.

Keir M, Ebert P, Kovacs AH, Smith JMC, Kwan E, Field TS, Brossard-Racine M, Marelli A.

Can J Cardiol. 2019 Dec;35(12):1675-1685. doi: 10.1016/j.cjca.2019.06.020. Epub 2019 Jun 26. Review.

PMID: 31570238

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Select item 31564390

 

  1. Right Ventricular Diastolic Function and Right Atrial Function and Their Relation With Exercise Capacity in Ebstein Anomaly.

Akazawa Y, Fujioka T, Kühn A, Hui W, Slorach C, Roehlig C, Mertens L, Vogt M, Friedberg MK.

Can J Cardiol. 2019 Dec;35(12):1824-1833. doi: 10.1016/j.cjca.2019.05.036. Epub 2019 Jun 12.

PMID: 31564390

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Select item 31473068

 

  1. Slower Skeletal Muscle Oxygenation Kinetics in Adults With Complex Congenital Heart Disease.

Sandberg C, Crenshaw AG, Elçadi GH, Christersson C, Hlebowicz J, Thilén U, Johansson B.

Can J Cardiol. 2019 Dec;35(12):1815-1823. doi: 10.1016/j.cjca.2019.05.001. Epub 2019 May 7.

PMID: 31473068

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Select item 31871513

 

  1. Recent advances in our understanding of neurodevelopmental outcomes in congenital heart disease.

White BR, Rogers LS, Kirschen MP.

Curr Opin Pediatr. 2019 Dec;31(6):783-788. doi: 10.1097/MOP.0000000000000829.

PMID: 31693588

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Select item 31398317

 

  1. Pulmonary arterial hypertension populations of special interest: portopulmonary hypertension and pulmonary arterial hypertension associated with congenital heart disease.

Savale L, Manes A.

Eur Heart J Suppl. 2019 Dec;21(Suppl K):K37-K45. doi: 10.1093/eurheartj/suz221. Epub 2019 Dec 17.

PMID: 31857799 Free PMC Article

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Select item 31504392

 

  1. [Current clinical applications of three-dimensional echocardiography].

Badano LP, Aruta P, Nguyen K, Palermo C, Baritussio A, Cecchetto A, Previtero M, Figliozzi S, Genovese D, Guta AC, Ochoa-Jimenez RC, Parati G, Muraru D.

G Ital Cardiol (Rome). 2019 Dec;20(12):722-735. doi: 10.1714/3271.32381. Italian.

PMID: 31834296

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Tulloh R, Dimopoulos K, Condliffe R, Clift P; CHAMPION Steering Committee.

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Qin C, Yan Y, Gan C.

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Jersak T, Gustin J, Humphrey L.

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Ducas R, Nguyen ET, Wald RM.

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  1. [Cardiovascular imaging in heart failure].

Nhan P, Ederhy S, Soulat-Dufour L, Ancedy Y, Chauvet-Droit M, Adavane-Scheublé S, Ben Said R, Lajus M, Boccara F, Cohen A.

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  1. The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography.

Mărginean CO, Meliţ LE, Ghiga DV, Săsăran MO.

Sci Rep. 2019 Dec 24;9(1):19800. doi: 10.1038/s41598-019-56358-2.

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Congenital Heart and Pediatric Cardiac Electrophysiology Featured Articles

Congenital Heart and Pediatric Cardiac Featured EP Manuscripts of December 2019

Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease.

Yanrong Yin, MD1; Konstantinos Dimopoulos, MD, PhD2; Eriko Shimada, MD3; Karen Lascelles, PGDip2; Samuel Griffiths, MSc2; Tom Wong, MD, PhD2; Michael A. Gatzoulis, MD, PhD2; Sonya V. Babu‐Narayan, MBBS, BSc, PhD2; Wei Li, MD, PhD*,2

J Am Heart Assoc. 2019 Dec 17;8(24):e014507. doi: 10.1161/JAHA.119.014507. Epub 2019 Dec 10. No abstract available.

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Take Home Points:

 

  • Heart failure and systemic ventricular dysfunction are a growing problem in older ACHD patients
  • Cardiac Resynchronization Therapy (CRT) was effective in improving NYHA Class in 1-2 (Early) and 4-5 years (Late) after CRT placement in ACHD patients
  • CRT was effective in improving systemic left ventricular function 1-2 years and 4-5 years after CRT placement in ACHD patients
  • CRT was not effective in improving systemic right ventricular function 1-2 years and 4-5 years after CRT placement in ACHD patients
  • QRS duration was the only predictor of CRT response though systemic LV morphology appears to important as well.
  • CRT implantation can be achieved in biventricular circulation but does carry a high rate of device implant complications (20%).
  • CRT should be considered in patients who meet criteria from the 2014 PACES/HRS Expert Consensus Statement on the Recognition and Management of Arrhythmias in Adult Congenital Heart Disease.

 

Comment from Dr. Akash Patel (San Francisco), section editor of Congenital Electrophysiology Journal Watch.  As congenital heart disease patients continue to survive into older adulthood, the population of patients at risk for developing heart failure will continue to increase.  The use of cardiac resynchronization therapy (CRT) for the treatment of heart failure in adults with congenital heart disease (ACHD) is poorly understood due to the limited number of patients, heterogeneity of congenital heart disease lesions, morphology of the systemic failing ventricle (right vs. left), impact of single ventricle vs. biventricular circulation, and short duration of follow-up.  This study aimed to assess the impact of early and late effects of CRT in ACHD.

This was a retrospective single center study of all patients with ACHD who had reduced systemic ventricular function (LV Ejection Fraction (LVEF) < 40% or RV Fractional Area Change (RV FAC) < 35%), received CRT between 2004 and 2017, and had >90% biventricular pacing.  The clinical practice for determining who underwent CRT placement during this time period was made on an individual basis through a multidisciplinary team approach (ACHD Cardiologist, Electrophysiologist, and Congenital Surgeon).  After implantation, optimization of device programming was based on routine clinical practice.  Baseline clinical, device, electrocardiographic, and echocardiographic data were obtained. Follow-up data was obtained during two time periods: early (1-2 years after CRT) and late (4-5 years after CRT).  Outcome measures included death, heart transplantation, and positive response to CRT defined as a 5% absolute increase in LVEF or RVFAC at follow-up.

The study group included 54 patients who had reduced systemic ventricular function, a CRT device implanted with BiV pacing >90%, and acceptable imaging.  The majority of patients had systemic left ventricles (72%). The lesions included were LVOT lesions (31%), ccTGA (24%), TOF (20%), others systemic LV (20%), and other systemic RV (4%). See figure below.

 

The mean age of the cohort was 46 ± 13 years with 74% male and a mean follow-up of 5.7± 3.0 years after CRT. 96% had NYHA Class II-IV heart failure. Baseline demographic in Table below.

 

 

 

Demographic and clinical characteristics  
Age at CRT implantation (Years) 46 ± 13
Men 40 (74%)
Follow-up duration  5.7 ± 3.0
SBP at CRT implantation, mmHg 112 ± 15
DBP at CRT implantation, mmHg 70 ± 10
BMI, kg/m2 25.7 (22.9–29.7)
Biochemical parameters  
Urea, mmol/L 7.1 (5.2–7.9)
Creatinine, Imol/L 84 (76–94)
NYHA functional class
I 3 (6%)
II 20 (37%)
III 28 (51%)
IV 3 (6%)
Drug treatment
ACEI or ARB 52 (96%)
Beta-Blocker 48 (89%)
Aldosterone antagonist 35 (65%)
Loop diuretic 28 (52%)
Amiodarone  11 (20%)
Anticoagulation  36 (67%)
Digoxin  5 (9%)

 

The majority of patients were in sinus rhythm (81%) with the remainder in permanent atrial fibrillation which effected pacing modality (VVIR/DDIR in 15%).  As expected, the majority of ACHD patients had a non-LBBB QRS morphology (72%).  See table below.

 

ECG
Sinus rhythm  44 (81%)
Atrial fibrillation 10 (19%)
QRS duration, ms 174 ± 27
QRS morphological characteristics
LBBB 15 (28%)
Non-LBBB 39 (72%)

 

Retrospective review of device indications for CRT based on the 2014 PACES/HRS Expert Consensus Statement on the Recognition and Management of Arrhythmias in Adult Congenital Heart Disease showed the majority met criteria. 44 (81%) had systemic dysfunction (LVEF/RVFAC 35%), clinical heart failure (NYHA Class II-IV), and electrical dyssynchrony (QRS 120 msec).   There were 8 (15%) patients who has >40% pacing (5 with systemic LVEF > 35% and 3 with NYHA Class I). There were 2 (4%) patients who had systemic LVEF > 35% and broadening QRS duration.

 

Device implantation occurred due to high grade heart block in 61%.  The majority of patients had an existing device (57%).  A CRT-D was implanted in 85% and CRT-P in 15%. See figure below.

 

Device implantation
Permanent Pacemaker/ICD upgrade to CRT 31 (57%)
   Permanent Pacemaker 21
   ICD 10
CRT de novo 23 (43%)
CRT-D 46 (85%)
CRT-P  8 (15%)

 

Implantation approach varied based on congenital heart lesion.  96% had a standard CRT approach with leads placed in the right atrium, non-systemic ventricle, and systemic ventricle via coronary sinus branch.  4% had an epicardial or hybrid approach.

 

Device complication were noted in 19% with infection as the most common complication. See Table below.

 

Device-related complications
Infection 5 (9%)
Lead dislodgement  3 (6%)
Venous obstruction  1 (2%)
Pneumohemothorax and pulmonary embolism  1 (2%)

 

The effects of CRT were assessed at 1.8 ± 0.8 years (Early Period) and 4.7 ± 0.8 years (Late Period).   CRT was associated with improved cardiothoracic ratio, QRS duration, and NYHA Functional Class (p<0.05) during the Early Period.  Only NYHA Functional Class improved in the Late Period. See figure below.

NYHA Functional Class improved in the Early and Late Period with CRT (See Below). In the Early Period, improvement in functional class was seen 65%, no change was seen in 33%, and worsening was seen in 2%.  In the Late Period when compared to the Early Period, further improvement in functional class was seen in 2%, no change was seen in 37%, and worsening from prior class in 31%. Of note, only Late Period data on NYHA Functional Class was available in 70%. See figure below.

 

Response to CRT with a ≥ 5% increase in LVEF or RVFAC was seen in 65%.  Most responders had a systemic LV (74%) compared to systemic RV (40%).  There was significant improvement in ejection fraction at both the early and late period for systemic left ventricles. However, there was no significant improvement in RV fractional area change in the systemic right ventricles. See figures below.

On further echocardiographic assessment of systemic left ventricles, improved LVEF and LV End systolic volume persisted in Late Period follow-up.

On further echocardiographic assessment of systemic right ventricles, there was no significant improvement in RV function that persisted in the Late Period follow-up.

Predictors of CRT response on multivariate analysis showed only baseline QRS duration was a significant predictor (OR: 1.4 per every 10-msec increase in QRS duration; 95% CI, 1.042 1.838; p= 0.025). The QRS duration for responders vs non-responders was 182 ±23 msec vs. 159 ± 29 msec (p<0.007). There was no difference in QRS duration in those without or without a pre-existing pacemaker and prior pacemaker was not shown to be a risk factor.  See figure below.

Overall, 20% died from all-cause mortality between 4.2 and 11.8 years after CRT. Below are

Kaplan-Meier curves depicting freedom from death and heart transplantation from CRT in patients with systemic left and right ventricles. Of note, 2 patients listed for transplant were removed from the list due to clinical improvement with CRT.

This study demonstrates the efficacy of CRT in an older cohort of heterogenous ACHD patients with improvement in both NYHA Functional Class and systemic ventricular function. The design of this study allowed for analysis of early and late effects of CRT which had not previously been reported.

The improvements in ventricular function were seen at both short and long-term follow-up in those with systemic left ventricles but were not seen in those with systemic right ventricles. This lack of response may be reflective of the small sample size, heterogeneity of cardiac lesions, or ventricular morphology.  Overall, the majority of patients had an improvement (65%) or no change (33%) in NYHA Class early after CRT but a subsequent decline in NYHA Class was seen overtime in 31% raising concern for the long-term effectiveness of CRT in these patients.

The response to CRT was dependent on QRS duration consistent with data from adults without ACHD. However, bundle branch block morphology was not associated with response. In addition, left ventricular morphology plays an important role in those with the highest likelihood to respond.

Despite the positive effects of CRT in this population, 20% died of all-cause mortality. Identifying and improving methods to treat heart failure in the ACHD population is therefore critically important.

This study raises the importance of using CRT in ACHD with systemic ventricular dysfunction and heart failure. In particular, the study demonstrated minimal deleterious effects on cardiac function with significant potential benefits.  Clearly there are important anatomic and procedural aspects to consider as device complications were seen in 19%.  However, increased experience should result in reducing these issues.

Ultimately, more data is needed with larger sample sizes, more homogenous populations, and longer term follow-up to determine the response to CRT and better identify predictors to refine existing guidelines.  In addition, the cohort in this study focused only on the failing systemic RV and LV in biventricular circulation.  Further consideration is needed in those with failing single ventricles (RV vs. LV) or failing subpulmonary ventricles.

Management of heart failure in ACHD patients is important to reduce deaths, need for transplantations, reduce comorbidities, need for hospitalization, and improve quality of life. Similar to this study, a multidisciplinary individualistic approach is needed when determining CRT placement in ACHD patients until additional data is available.

 

CHD EP Dec 2019

 

  1. Long-term follow-up of implantable cardioverter-defibrillators in children: Indications and outcomes.

Kwiatkowska J, Budrejko S, Wasicionek M, Meyer-Szary FJ, Lubinski A, Kempa M.

Adv Clin Exp Med. 2019 Dec 30. doi: 10.17219/acem/110313. [Epub ahead of print]

PMID: 31895976

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  1. The incidence of arrhythmias during exercise stress tests among children with Kawasaki disease: A single-center case series.

Aggarwal V, Sexson-Tejtal K, Lam W, Valdes SO, de la Uz CM, Kim JJ, Miyake CY.

Congenit Heart Dis. 2019 Dec 23. doi: 10.1111/chd.12864. [Epub ahead of print]

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  1. Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease.

[No authors listed]

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PMID: 31818210 Free Article

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  1. Neonates and infants requiring life-long cardiac pacing: How reliable are epicardial leads through childhood?

Stanner C, Horndasch M, Vitanova K, Strbad M, Ono M, Hessling G, Lange R, Cleuziou J.

Int J Cardiol. 2019 Dec 15;297:43-48. doi: 10.1016/j.ijcard.2019.10.008. Epub 2019 Oct 9.

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  1. Impact of atrial arrhythmia on survival in adults with tetralogy of Fallot.

Egbe AC, Najam M, Banala K, Vojjini R, Bonnichsen C, Ammash NM, Faizee F, Khalil F, Deshmukh AJ, Connolly HM.

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  1. Technological Advances in Arrhythmia Management Applied to Adults With Congenital Heart Disease.

Mondésert B, Nair K, McLeod CJ, Khairy P.

Can J Cardiol. 2019 Dec;35(12):1708-1722. doi: 10.1016/j.cjca.2019.06.034. Epub 2019 Oct 5. Review.

PMID: 31813504

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Select item 31813503

 

  1. Arrhythmias in Adults With Congenital Heart Disease: What the Practicing Cardiologist Needs to Know.

Khairy P.

Can J Cardiol. 2019 Dec;35(12):1698-1707. doi: 10.1016/j.cjca.2019.07.009. Epub 2019 Jul 16. Review.

PMID: 31703824

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Select item 31635950

 

  1. Challenges in Ablation of Complex Congenital Heart Disease.

Van Hare GF.

Card Electrophysiol Clin. 2019 Dec;11(4):711-718. doi: 10.1016/j.ccep.2019.08.002. Review.

PMID: 31706477

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Select item 31679544

 

  1. Permanent pacing post-Fontan is not associated with reduced long-term survival.

Hall SJ, Cullington D, Thomson JDR, Bentham JR.

Cardiol Young. 2019 Dec;29(12):1432-1434. doi: 10.1017/S104795111900194X. Epub 2019 Oct 11.

PMID: 31601284

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  1. Current Review of Implantable Cardioverter Defibrillator Use in Patients With Left Ventricular Assist Device.

Boulet J, Massie E, Mondésert B, Lamarche Y, Carrier M, Ducharme A.

Curr Heart Fail Rep. 2019 Dec;16(6):229-239. doi: 10.1007/s11897-019-00449-8. Review.

PMID: 31768918

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Select item 31693588

 

  1. Association of Wolff-Parkinson-White With Left Ventricular Noncompaction Cardiomyopathy in Children.

Howard TS, Valdes SO, Hope KD, Morris SA, Landstrom AP, Schneider AE, Miyake CY, Denfield SW, Pignatelli RH, Wang Y, Kim JJ.

J Card Fail. 2019 Dec;25(12):1004-1008. doi: 10.1016/j.cardfail.2019.09.014. Epub 2019 Oct 15.

PMID: 31626950

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Select item 31794129

 

  1. Ultrahigh-density mapping supplemented with global chamber activation identifies noncavotricuspid-dependent intra-atrial re-entry conduction isthmuses in adult congenital heart disease.

Moore JP, Buch E, Gallotti RG, Shannon KM.

J Cardiovasc Electrophysiol. 2019 Dec;30(12):2797-2805. doi: 10.1111/jce.14251. Epub 2019 Nov 10.

PMID: 31646694

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Select item 31599783

 

  1. Evaluation of a near-zero fluoroscopic approach for catheter ablation in patients with congenital heart disease.

Cano Ó, Saurí A, Plaza D, Osca J, Sancho-Tello MJ, Rueda J, Osa A, Martínez-Dolz L.

J Interv Card Electrophysiol. 2019 Dec;56(3):259-269. doi: 10.1007/s10840-018-0467-3. Epub 2018 Oct 30.

PMID: 30377927

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Select item 31613695

 

  1. Ultra-High-Density Activation Mapping to Aid Isthmus Identification of Atrial Tachycardias in Congenital Heart Disease.

Martin CA, Yue A, Martin R, Claridge S, Sawhney V, Maury P, Lowe M, Combes N, Heck P, Begley D, Fynn S, Snowdon R, Seller N, Murray S, Shepherd E, Ezzat V, Gajendragadkar PR, Honarbakhsh S, Takigawa M, Cheniti G, Frontera A, Thompson N, Massouillie G, Kitamura T, Wolf M, Duchateau J, Klotz N, Vlachos K, Bourier F, Lam A, Pambrun T, Denis A, Sacher F, Cochet H, Jais P, Hocini M, Haissaguerre M, Iriart X, Thambo JB, Derval N.

JACC Clin Electrophysiol. 2019 Dec;5(12):1459-1472. doi: 10.1016/j.jacep.2019.08.001. Epub 2019 Oct 30.

PMID: 31857047

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Select item 31090912

 

  1. Survival and Cardiopulmonary Resuscitation Hemodynamics Following Cardiac Arrest in Children With Surgical Compared to Medical Heart Disease.

Yates AR, Sutton RM, Reeder RW, Meert KL, Berger JT, Fernandez R, Wessel D, Newth CJ, Carcillo JA, McQuillen PS, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Notterman DA, Dean JM, Nadkarni VM, Berg RA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network.

Pediatr Crit Care Med. 2019 Dec;20(12):1126-1136. doi: 10.1097/PCC.0000000000002088.

PMID: 31453988

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Select item 31865621

 

  1. Wolff-Parkinson-White Syndrome in an Adolescent With Familial Mediterranean Fever: A Coincidence?

Elmaci AM, Alp H.

J Clin Rheumatol. 2019 Dec 24. doi: 10.1097/RHU.0000000000001250. [Epub ahead of print] No abstract available.

PMID: 31880606

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Select item 31880662

 

  1. The incidence of arrhythmias during exercise stress tests among children with Kawasaki disease: A single-center case series.

Aggarwal V, Sexson-Tejtal K, Lam W, Valdes SO, de la Uz CM, Kim JJ, Miyake CY.

Congenit Heart Dis. 2019 Dec 23. doi: 10.1111/chd.12864. [Epub ahead of print]

PMID: 31868314

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Select item 31872208

 

  1. Accelerated idioventricular rhythm resulting in torsades de pointes and cardiac arrest in a child: successfully cryoablated in left’coronary cusp.

Ergul Y, Kafali HC, Uysal F.

Cardiol Young. 2019 Dec 20:1-4. doi: 10.1017/S1047951119002993. [Epub ahead of print]

PMID: 31858927

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Select item 31863208

 

  1. P wave dispersion in assessment of dysrhythmia risk in patients with secundum type atrial septal defect and the effect of transcatheter or surgical closure.

Cenk M, Akalın F, Şaylan BÇ, Ak K.

Cardiol Young. 2019 Dec 19:1-8. doi: 10.1017/S1047951119002828. [Epub ahead of print]

PMID: 31854289

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Select item 31854284

 

  1. Selective left bundle branch pacing for pediatric complete heart block.

Ponnusamy SS, Muthu G, Bopanna D.

Indian Pacing Electrophysiol J. 2019 Dec 19. pii: S0972-6292(19)30151-2. doi: 10.1016/j.ipej.2019.12.012. [Epub ahead of print]

PMID: 31866553 Free Article

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Select item 31866322

 

  1. Leadless Micra Pacemaker Use in the Pediatric Population: Device Implantation and Short-Term Outcomes.

Breatnach CR, Dunne L, Al-Alawi K, Oslizlok P, Kenny D, Walsh KP.

Pediatr Cardiol. 2019 Dec 19. doi: 10.1007/s00246-019-02277-y. [Epub ahead of print]

PMID: 31858200

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Select item 31852470

 

  1. Transcatheter Treatment of a Symptomatic Giant Iliac Artery Aneurysm with a BeGraft Peripheral Stent in a 2-Year-Old Child.

Başpınar O, Vuruşkan E, Coşkun S, Aldudak B.

Pediatr Cardiol. 2019 Dec 17. doi: 10.1007/s00246-019-02266-1. [Epub ahead of print]

PMID: 31848637

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Select item 31840633

 

  1. “If at first you don’t succeed”: repeat ablations in young patients with supraventricular tachycardia.

Rochelson E, Clark BC, Janson CM, Ceresnak SR, Nappo L, Pass RH.

J Interv Card Electrophysiol. 2019 Dec 13. doi: 10.1007/s10840-019-00672-2. [Epub ahead of print]

PMID: 31834569

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Select item 31843215

 

  1. OUTCOMES FOR CATHETER ABLATION OF ANTEROSEPTAL AND MIDSEPTAL ACCESSORY PATHWAYS IN PEDIATRIC PATIENTS.

Kovach JR, Mah DY, Abrams DJ, Alexander ME, Cecchin F, Triedman JK, Walsh EP.

Heart Rhythm. 2019 Dec 12. pii: S1547-5271(19)31100-2. doi: 10.1016/j.hrthm.2019.12.008. [Epub ahead of print]

PMID: 31838200

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Select item 31862516

 

  1. Myocardial deformation as a predictor of right ventricular pacing-induced cardiomyopathy in the pediatric population.

Dasgupta S, Madani R, Figueroa J, Cox D, Ferguson E, Border W, Sachdeva R, Fischbach P, Whitehill R.

J Cardiovasc Electrophysiol. 2019 Dec 11. doi: 10.1111/jce.14312. [Epub ahead of print]

PMID: 31828872

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Select item 31825129

 

  1. Electrocardiographic changes and long-term prognosis of children diagnosed with hypertrophic cardiomyopathy by the school screening program for heart disease in Japan.

Morimoto Y, Miyazaki A, Tsuda E, Hayama Y, Negishi J, Ohuchi H.

J Cardiol. 2019 Dec 10. pii: S0914-5087(19)30341-7. doi: 10.1016/j.jjcc.2019.10.008. [Epub ahead of print]

PMID: 31836272

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  1. Outcome of patients with functional single ventricular heart after pacemaker implantation: What makes it poor, and what can we do?

Kodama Y, Kuraoka A, Ishikawa Y, Nakamura M, Ushinohama H, Sagawa K, Umemoto S, Hashimoto T, Sakamoto I, Ohtani K, Ide T, Tsutsui H, Ishikawa S.

Heart Rhythm. 2019 Dec;16(12):1870-1874. doi: 10.1016/j.hrthm.2019.06.019. Epub 2019 Jun 25.

PMID: 31252085

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Select item 31388920

 

  1. Phenotypic variability in a series of four pediatric patients with Andersen-Tawil syndrome: A Saudi experience.

Alrashed NA, Al-Manea WM, Tulbah SA, Al-Hassnan ZN.

Int J Pediatr Adolesc Med. 2019 Dec;6(4):158-164. doi: 10.1016/j.ijpam.2019.06.005. Epub 2019 Jun 14.

PMID: 31890843 Free PMC Article

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Select item 30991120

 

  1. Association of Wolff-Parkinson-White With Left Ventricular Noncompaction Cardiomyopathy in Children.

Howard TS, Valdes SO, Hope KD, Morris SA, Landstrom AP, Schneider AE, Miyake CY, Denfield SW, Pignatelli RH, Wang Y, Kim JJ.

J Card Fail. 2019 Dec;25(12):1004-1008. doi: 10.1016/j.cardfail.2019.09.014. Epub 2019 Oct 15.

PMID: 31626950

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Select item 30986498

 

  1. Quantitative T-wave morphology assessment from surface ECG is linked with cardiac events risk in genotype-positive KCNH2 mutation carriers with normal QTc values.

Cortez D, Zareba W, McNitt S, Polonsky B, Rosero SZ, Platonov PG.

J Cardiovasc Electrophysiol. 2019 Dec;30(12):2907-2913. doi: 10.1111/jce.14210. Epub 2019 Oct 16.

PMID: 31579959

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Select item 31609850

 

  1. Magnetic resonance imaging of patients with epicardial leads: in vitro evaluation of temperature changes at the lead tip.

Balmer C, Gass M, Dave H, Duru F, Luechinger R.

J Interv Card Electrophysiol. 2019 Dec;56(3):321-326. doi: 10.1007/s10840-019-00627-7. Epub 2019 Nov 12.

PMID: 31713219

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Select item 31561960

 

  1. Pulseless ventricular tachycardia and ventricular fibrillation complicating severe traumatic brain injury in pediatrics.

Piastra M, Tortorolo L, Genovese O, Morena TC, Picconi E, De Rosa G, Conti G.

Minerva Anestesiol. 2019 Dec;85(12):1366-1367. doi: 10.23736/S0375-9393.19.13737-6. Epub 2019 Sep 3. No abstract available.

PMID: 31486621

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Select item 27652994

 

  1. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors.

Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN.

Pediatr Cardiol. 2019 Dec;40(8):1679-1687. doi: 10.1007/s00246-019-02203-2. Epub 2019 Sep 18.

PMID: 31535183

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  1. “Chaotic Arrhythmia” During Successful Resuscitation After Ingestion of Yew (Taxus baccata) Needles.

Zutter A, Hauri K, Evers KS, Uhde S, Fassl J, Reuthebuch OT, Berset A, Kühne M, Donner BC.

Pediatr Emerg Care. 2019 Dec;35(12):e223-e225. doi: 10.1097/PEC.0000000000001196.

PMID: 28590987

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Select item 31738731

 

  1. Spanish Catheter Ablation Registry. 18th Official Report of the Spanish Society of Cardiology Working Group on Electrophysiology and Arrhythmias (2018).

Ibáñez Criado JL, Quesada A, Cózar R; Spanish Catheter Ablation Registry collaborators; Appendix 1. REGISTRY COLLABORATORS.

Rev Esp Cardiol (Engl Ed). 2019 Dec;72(12):1031-1042. doi: 10.1016/j.rec.2019.08.005. Epub 2019 Nov 13. English, Spanish.

PMID: 31732435

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  1. [Electrophysiological properties of asymptomatic children and adolescents with the Wolff-Parkinson-White electrocardiographic pattern].

Koca S, Akdeniz C, Tuzcu V.

Turk Kardiyol Dern Ars. 2019 Dec;47(8):674-679. doi: 10.5543/tkda.2019.41354. Turkish.

PMID: 31802767 Free Article

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  1. Arrhythmias in Children with Peripherally Inserted Central Catheters (PICCs).

Dhillon SS, Connolly B, Shearkhani O, Brown M, Hamilton R.

Pediatr Cardiol. 2019 Dec 18. doi: 10.1007/s00246-019-02274-1. [Epub ahead of print]

PMID: 31853581

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Congenital Heart Interventions Featured Articles

Congenital Interventional Cardiology Reviews of December 2019 Manuscripts

Here today, gone tomorrow: Outcomes of residual leak following secundum atrial septal defect closure with the GORE CARDIOFORM Septal Occluder.

Gordon BM, Abudayyeh I, Goble J, Collado NA, Paolillo J.

Catheter Cardiovasc Interv. 2019 Dec 26. doi: 10.1002/ccd.28666. [Epub ahead of print]

PMID: 31876383

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Select item 31909179

 Take Home Points: 

  • The GSO is safe and effective in closing small to moderate atrial septal defects.
  • Small residual defects are fairly common (17.6%), especially in larger defects, multifenestrated defects, and those with a deficient retroaortic rim.
  • The large majority of these residual defects (87.6%) are not seen by transthoracic echocardiography at 1 year follow up.

Commentary from Dr. Ryan Romans (Kansas City, MO), section editor of Congenital Heart Disease Interventions Journal Watch:  Transcatheter device closure of atrial septal defects (ASDs) is well accepted as the first-line treatment option in amenable defects. The GORE CARDIOFORM Septal Occluder (GSO) received CE mark in June of 2011. The GSO is made of five nitinol wires with a platinum core wires that create a double disc frame composed of 10 petals (5 on each side) covered by an expanded polytetrafluoroethylene (ePTFE) membrane. It can be used to close secundum atrial septal defects up to 17-18 mm in size. The GSO is different from other ASD closure devices available in that it is a nonself-centering device that just has a central eyelet connecting the two discs. It depends on an adequate device to defect ratio to completely cover the ASD while allowing for endothelialization.  Other ASD closure devices have a central waist embedded with fabric to promote closure that fills the ASD (self-centering device). Because the device does not have a central waist to fill the defect and keep it centered within the ASD, it can shift after placement to conform to the septal anatomy.  This could potentially lead to small leaks around the device.

In order to evaluate the frequency of residual defects immediately after placement and medium term outcomes of these residual defects, Gordon et al performed a retrospective review of all patients who underwent ASD closure with a GSO as part of the pivotal and continued access U.S. trials. There were 370 total ASD device closures with the GSO. Of these, 65 (17.6%) had a residual leak. 4 patients with a residual leak were excluded from analysis (3 for inadequate device position on review of the echocardiogram, 1 who had a satellite defect not in contact with the device). Patients who had a residual leak were more likely to have larger defects (10.33 ± 3.05 mm versus 9.13 ± 2.89 mm), smaller retroaortic rims (4.87 ± 3.33 mm versus 6.17 ± 3.78 mm), and a multifenestrated defect. These patients were also more likely to have had transesophageal echocardiography to guide closure (TEE likely visualizes the entire atrial septum more thoroughly than transthoracic echocardiography and intracardiac echocardiography), longer fluoroscopy times, larger devices implanted, and more devices per procedure utilized. At 1 year follow up (routinely performed as part to the trial), there was a decrease in the size of the defect from 1.55 ± 0.75 mm to 0.25 ± 0.74 mm with the majority of residual defects (87.6%) no longer seen.

The GSO has been shown to be safe and extremely effective for closure of small-moderate sized secundum ASDs. This study shows that small residual leaks are fairly common after device implantation but that the large majority of these are not seen at 1 year follow up. Larger defects, deficient retroaortic rims, and multifenestrated defects are more likely to have a residual defect at the time of implantation. The authors hypothesize that resolution of the defects may be due remodeling and subsequent normalization of the right atrial size after the volume load from the ASD is removed. This decrease in size may allow more of the device to come in contact with the surrounding tissue and promote endothelialization. They note that in larger defects with deficient retroaortic rims they will often implant a larger device than may be needed based on the ASD size if the total septal length and LA size will allow it (I have adopted and had success with this practice as well). Overall, the device has excellent an excellent mid-term outcome of complete closure of the ASD.

 

 

CHD Interventions Dec 2019

 

  1. Here today, gone tomorrow: Outcomes of residual leak following secundum atrial septal defect closure with the GORE CARDIOFORM Septal Occluder.

Gordon BM, Abudayyeh I, Goble J, Collado NA, Paolillo J.

Catheter Cardiovasc Interv. 2019 Dec 26. doi: 10.1002/ccd.28666. [Epub ahead of print]

PMID: 31876383

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  1. Left ventricular filling pressure in Tetralogy of Fallot: Correlation between invasive and noninvasive indices.

Egbe AC, Banala K, Vojjini R, Jadav R, Sufian M, Pellikka PA, Ammash NM.

Int J Cardiol Heart Vasc. 2019 Dec 26;26:100457. doi: 10.1016/j.ijcha.2019.100457. eCollection 2020 Feb.

PMID: 31909179

 

Select item 31883956

 

  1. Left recurrent laryngeal nerve palsy following aortic arch stenting: A case report.

Fürniss HE, Hummel J, Stiller B, Grohmann J.

World J Cardiol. 2019 Dec 26;11(12):316-321. doi: 10.4330/wjc.v11.i12.316.

PMID: 31908731 Free Article

 

Select item 31875732

 

  1. Experience of percutaneous coronary intervention in the pediatric and adolescent population in a referral center for congenital heart disease.

Fernández González L, Ballesteros Tejerizo F, Rodríguez Ogando A, Zunzunegui Martínez JL, Gutiérrez Ibañes E, Sanz Ruiz R.

Rev Esp Cardiol (Engl Ed). 2019 Dec 23. pii: S1885-5857(19)30404-9. doi: 10.1016/j.rec.2019.10.015. [Epub ahead of print] English, Spanish. No abstract available.

PMID: 31879234

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  1. Different CMR Imaging Modalities for Native and Patch-Repaired Right Ventricular Outflow Tract Sizing: Impact on Percutaneous Pulmonary Valve Replacement Planning.

Ferrari I, Shehu N, Mkrtchyan N, Martinoff S, Eicken A, Stern H, Ewert P, Meierhofer C.

Pediatr Cardiol. 2019 Dec 19. doi: 10.1007/s00246-019-02270-5. [Epub ahead of print]

PMID: 31858202

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  1. Preprocedural three-dimensional planning aids in transcatheter ductal stent placement: A single-center experience.

Chamberlain RC, Ezekian JE, Sturgeon GM, Barker PCA, Hill KD, Fleming GA.

Catheter Cardiovasc Interv. 2019 Dec 18. doi: 10.1002/ccd.28669. [Epub ahead of print]

PMID: 31854085

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  1. 3-Dimensional personalized planning for transcatheter pulmonary valve implantation in a dysfunctional right ventricular outflow tract.

Pluchinotta FR, Sturla F, Caimi A, Giugno L, Chessa M, Giamberti A, Votta E, Redaelli A, Carminati M.

Int J Cardiol. 2019 Dec 6. pii: S0167-5273(19)34925-3. doi: 10.1016/j.ijcard.2019.12.006. [Epub ahead of print]

PMID: 31839428

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  1. Pulmonary Valve Replacement for Pulmonary Regurgitation in Adults With Tetralogy of Fallot: A Meta-analysis-A Report for the Writing Committee of the 2019 Update of the Canadian Cardiovascular Society Guidelines for the Management of Adults With Congenital Heart Disease.

Mongeon FP, Ben Ali W, Khairy P, Bouhout I, Therrien J, Wald RM, Dallaire F, Bernier PL, Poirier N, Dore A, Silversides C, Marelli A.

Can J Cardiol. 2019 Dec;35(12):1772-1783. doi: 10.1016/j.cjca.2019.08.031. Epub 2019 Aug 29. Review.

PMID: 31813508

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  1. Percutaneous Valve Interventions in the Adult Congenital Heart Disease Population: Emerging Technologies and Indications.

Greutmann M, Benson L, Silversides CK.

Can J Cardiol. 2019 Dec;35(12):1740-1749. doi: 10.1016/j.cjca.2019.10.019. Epub 2019 Oct 24. Review.

PMID: 31813506

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Select item 31813505

 

  1. Transcatheter closure of right pulmonary artery to left atrium fistula in an infant: technical consideration and possible closure techniques.

Arya V, Azad S, Radhakrishnan S.

Cardiol Young. 2019 Dec;29(12):1561-1564. doi: 10.1017/S1047951119002592. Epub 2019 Nov 4.

PMID: 31679544

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Select item 31662138

 

  1. Giving up knowledge is almost never a good idea: an interview with Dr Evan Zahn.

Góreczny S, Zahn EM.

Cardiol Young. 2019 Dec;29(12):1419-1425. doi: 10.1017/S1047951119002117. Epub 2019 Oct 30.

PMID: 31662138

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Select item 31601284

 

  1. Percutaneous embolization of lymphatic fistulae as treatment for protein-losing enteropathy and plastic bronchitis in patients with failing Fontan circulation.

Maleux G, Storme E, Cools B, Heying R, Boshoff D, Louw JJ, Frerich S, Malekzadeh-Milanii S, Hubrechts J, Brown SC, Gewillig M.

Catheter Cardiovasc Interv. 2019 Dec 1;94(7):996-1002. doi: 10.1002/ccd.28501. Epub 2019 Oct 9.

PMID: 31596530

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Select item 31471939

 

  1. Initial experience with vascular plug devices for mechanical thrombectomy in symptomatic neonates and infants.

McGovern E, Qureshi AM, Goldstein BH.

Catheter Cardiovasc Interv. 2019 Dec 1;94(7):989-995. doi: 10.1002/ccd.28486. Epub 2019 Aug 30.

PMID: 31471939

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Select item 31760821

 

  1. Congenital and Structural Heart Disease Interventions Using Echocardiography-Fluoroscopy Fusion Imaging.

Jone PN, Haak A, Ross M, Wiktor DM, Gill E, Quaife RA, Messenger JC, Salcedo EE, Carroll JD.

J Am Soc Echocardiogr. 2019 Dec;32(12):1495-1504. doi: 10.1016/j.echo.2019.07.023. Epub 2019 Oct 6. Review.

PMID: 31597599

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Select item 31801327

 

  1. Successful transcatheter pulmonary valve implantation in a dog: first clinical report.

Borenstein N, Chetboul V, Passavin P, Morlet A, Fernandez-Parra R, Carazo Arias LE, Giannettoni G, Saponaro V, Poissonnier C, Ghazal S, Lefort S, Trehiou-Sechi E, Marchal CR, Delle Cave J, Vannucci E, Behr L, Verwaerde P.

J Vet Cardiol. 2019 Dec;26:10-18. doi: 10.1016/j.jvc.2019.10.001. Epub 2019 Oct 15.

PMID: 31785529

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Select item 30031706

 

  1. Optical Coherence Tomography for the Early Detection of Coronary Vascular Changes in Children and Adolescents After Cardiac Transplantation: Findings From the International Pediatric OCT Registry.

McGovern E, Hosking MCK, Balbacid E, Voss C, Berger F, Schubert S, Harris KC.

JACC Cardiovasc Imaging. 2019 Dec;12(12):2492-2501. doi: 10.1016/j.jcmg.2018.04.025. Epub 2018 Jul 18.

PMID: 30031706

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  1. Percutaneous closure of restrictive-type perimembranous ventricular septal defect using the new KONAR multifunctional occluder: Midterm outcomes of the first middle-eastern experience.

Haddad RN, Daou LS, Saliba ZS.

Catheter Cardiovasc Interv. 2019 Dec 30. doi: 10.1002/ccd.28678. [Epub ahead of print]

PMID: 31886940

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  1. Risk factors for adverse events within one year after atrial septal closure in children: a retrospective follow-up study.

Tanghöj G, Liuba P, Sjöberg G, Naumburg E.

Cardiol Young. 2019 Dec 18:1-10. doi: 10.1017/S1047951119002919. [Epub ahead of print]

PMID: 31847927

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  1. Device Closure of Iatrogenic Left Ventricular Perforation Through the Chest Wall.

McGill M, Aggarwal V, Hiremath G.

JACC Cardiovasc Interv. 2019 Dec 18. pii: S1936-8798(19)32161-2. doi: 10.1016/j.jcin.2019.10.011. [Epub ahead of print] No abstract available.

PMID: 31883718

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Select item 31853582

 

  1. Stent treatment of ostial branch pulmonary artery stenosis: initial and medium-term outcomes and technical considerations to avoid and minimise stent malposition.

Patel ND, Sullivan PM, Takao CM, Badran S, Ing FF.

Cardiol Young. 2019 Dec 13:1-7. doi: 10.1017/S1047951119003032. [Epub ahead of print]

PMID: 31831087

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  1. Animal Models of Repaired Tetralogy of Fallot: Current Applications and Future Perspectives.

Valdeomillos E, Jalal Z, Metras A, Roubertie F, Benoist D, Bernus O, Haïssaguerre M, Bordachar P, Iriart X, Thambo JB.

Can J Cardiol. 2019 Dec;35(12):1762-1771. doi: 10.1016/j.cjca.2019.07.622. Epub 2019 Jul 26. Review.

PMID: 31711822

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Select item 31564390

 

 

  1. Endovascular coil embolization of a complex aortic arch pseudoaneurysm following arch stenting.

Meijs TA, Krings GJ, Molenschot MMC, Voskuil M.

Catheter Cardiovasc Interv. 2019 Dec 1;94(7):1006-1009. doi: 10.1002/ccd.28424. Epub 2019 Aug 7.

PMID: 31389117 Free PMC Article

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Select item 31068677

 

  1. Intravascular Papillary Endothelial Hyperplasia in the Coronary Artery: An Unusual Cause of Massive Myocardial Infarction in Hypoplastic Left Heart Syndrome.

Safa R, Garcia R, Delius R, Kaur G, Youssef L, Poulik J, Shehata BM.

Fetal Pediatr Pathol. 2019 Dec;38(6):511-517. doi: 10.1080/15513815.2019.1613704. Epub 2019 May 14.

PMID: 31084387

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Select item 31788738

 

  1. Very late-onset complete atrioventricular block following deployment of Amplatzer membranous ventricular septal defect occluder.

Shao S, Luo C, Zhou K, Hua Y, Wang C.

Medicine (Baltimore). 2019 Dec;98(51):e18412. doi: 10.1097/MD.0000000000018412.

PMID: 31861006 Free Article

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Select item 31499571

 

  1. Covered Stent as a Bridge to Surgery for Obstructive Melody Pulmonary Valve Endocarditis.

Sirico D, Vîjîiac A, Kempny A, Michielon G, Fraisse A.

Pediatr Cardiol. 2019 Dec;40(8):1752-1755. doi: 10.1007/s00246-019-02168-2. Epub 2019 Jul 27.

PMID: 31352491

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Congenital Heart Surgery

Congenital Heart Surgery Reviews of December 2019 Manuscripts

Midterm Outcomes of the Supported Ross Procedure in Children, Teenagers and Young Adults.

Riggs KW, Colohan DB, Beacher DR, Alsaied T, Powell S, Moore RA, Ginde S, Tweddell JS.

Semin Thorac Cardiovasc Surg. 2019 Dec 18. pii: S1043-0679(19)30391-0. doi: 10.1053/j.semtcvs.2019.10.020. [Epub ahead of print]

PMID: 31863831

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Take Home Points: 

  • The Ross procedure is an excellent option for aortic valve replacement in children and young adults, but dilation of the pulmonary autograft can lead to the need for further surgery.
  • The supported Ross procedure has been designed to minimize the risk of pulmonary autograft dilation and this single-center review supports this decreased risk with mid-term data on 40 patients. 

Commentary from Dr. Timothy Pirolli (Dallas), section editor of Congenital Heart Surgery Journal Watch:  The Ross procedure involves replacing the aortic valve with a pulmonary autograft and then using a pulmonary homograft for replacement of the pulmonary valve and main pulmonary artery. This procedure has proven very effective for younger patients and avoids the need for anticoagulation. However, the pulmonary autograft can dilate over time creating neoaortic root dilation and aortic regurgitation, necessitating further surgery. In 2005, a modified version of the Ross procedure was described by Ungerleider et al. The modification involved the use of a slightly oversized Dacron tube graft to surround and support the pulmonary autograft to minimize the ability of the autograft to dilate with time. The mid-term results of the supported Ross procedure from two centers are presented here.

The authors used retrospective data from Cincinnati Children’s and Children’s Hospital of Wisconsin to evaluate 40 patients’ outcomes from 2005-2018. The study does not explicitly mention the detail that the senior author worked at both institutions during this time period and it does not specify how many surgeons performed the surgeries during this time period. The outcomes examined included survival, cardiac reintervention and aortic dimensions from serial echocardiograms. The patients ranged in ages from 10-35 years old (median age of 16 years) and median length of follow-up was 3.5 years (1.4-5.6 years) with only 3 patients followed for >10 years.

The graph depicting root dilation in this cohort is shown in graph 1 below. A z-score >2.5 was used as the cut off to define > mild dilation of the neoaortic root. Figure 1 gives a schematic drawing of the supported Ross procedure. The key component to the surgery is that the graft was sized ~ 4mm greater than the size of the pulmonary autograft. To allow adequate neoaortic growth, this limited the use of the supported Ross to patients older than 10-12 years. The comparison between average discharge and follow-up echo measurements are in Figure 3. There were no deaths during the study period. Five patients required reintervention, but only one of those required an aortic valve replacement.

This study supports the use of supported Ross in select patients above a certain age for aortic valve replacement. The mid-term results are good. The long-term results are obviously needed, but this will take many years to obtain. The size cutoff of a pulmonary autograft of 25 mm is helpful for practitioners seeking to utilize this procedure on their own patients. This can obviously be elucidated clearly preoperatively using CT scan or possibly echocardiography. The major questions that are left after reviewing this paper is are these results durable long-term and are they able to be duplicated in the hands of other surgeons? Certainly, these results are encouraging and should serve as a solid foundation for future studies and the care of young patients with aortic valve disease that requires valve replacement.

Tables and Figures

 

 

 

 

CHD Surgery Dec 2019

 

  1. Expanding the donor pool for congenital heart disease transplant candidates by implementing 3D imaging-derived total cardiac volumes.

Shugh SB, Szugye NA, Zafar F, Riggs KW, Villa C, Lorts A, Morales DLS, Moore RA.

Pediatr Transplant. 2019 Dec 27:e13639. doi: 10.1111/petr.13639. [Epub ahead of print]

PMID: 31880070

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Select item 31876989

 

  1. From surviving to thriving – parental experiences of hospitalised infants with congenital heart disease undergoing cardiac surgery: A qualitative synthesis.

McMahon E, Chang YS.

J Pediatr Nurs. 2019 Dec 26;51:32-41. doi: 10.1016/j.pedn.2019.12.010. [Epub ahead of print] Review.

PMID: 31884242

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Select item 31908731

 

  1. Serum vitamin D status following pediatric cardiac surgery and association with clinical outcome.

Dohain AM, Almogati J, Al-Radi OO, Elassal AA, Zaher ZF, Fatani TH, Abdulgawad A, Abdelmohsen G.

Eur J Pediatr. 2019 Dec 21. doi: 10.1007/s00431-019-03538-x. [Epub ahead of print]

PMID: 31865429

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Select item 31865442

 

  1. Mitral Valve Surgery in the First Year of Life.

Geoffrion TR, Pirolli TJ, Pruszynski J, Dyer AK, Davies RR, Forbess JM, Guleserian KJ.

Pediatr Cardiol. 2019 Dec 21. doi: 10.1007/s00246-019-02262-5. [Epub ahead of print]

PMID: 31865441

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Select item 31858817

 

  1. Surgical Aortic Valve Replacement: Are We Able to Improve Hemodynamic Outcome?

Yevtushenko P, Hellmeier F, Bruening J, Nordmeyer S, Falk V, Knosalla C, Kelm M, Kuehne T, Goubergrits L.

Biophys J. 2019 Dec 17;117(12):2324-2336. doi: 10.1016/j.bpj.2019.07.025. Epub 2019 Jul 22.

PMID: 31427066

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Select item 31847826

 

  1. Computed tomography findings of mediastinitis after cardiovascular surgery.

Hosokawa T, Yamada Y, Tanami Y, Sato Y, Ko Y, Nomura K, Oguma E.

Pediatr Int. 2019 Dec 17. doi: 10.1111/ped.14101. [Epub ahead of print]

PMID: 31845441

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Select item 31862220

 

  1. Outcome of adult congenital heart disease patients undergoing cardiac surgery: clinical experience of dr. Sardjito hospital.

Kurniawaty J, Widyastuti Y.

BMC Proc. 2019 Dec 16;13(Suppl 11):16. doi: 10.1186/s12919-019-0178-5. eCollection 2019.

PMID: 31890009 Free PMC Article

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  1. The Organ-Protective Effect of Higher Partial Pressure of Arterial Carbon Dioxide in the Normal Range for Infant Patients Undergoing Ventricular Septal Defect Repair.

Fan F, Xie S, Ou-Yang C, Liu Y.

Pediatr Cardiol. 2019 Dec 16. doi: 10.1007/s00246-019-02269-y. [Epub ahead of print]

PMID: 31844927

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  1. Growth stunting in single ventricle patients after heart transplantation.

Power A, Schultz L, Dennis K, Rizzuto S, Hollander AM, Rosenthal DN, Almond CS, Hollander SA.

Pediatr Transplant. 2019 Dec 16:e13634. doi: 10.1111/petr.13634. [Epub ahead of print]

PMID: 31845499

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Select item 31409095

 

  1. Ventricular Dysfunction Is a Critical Determinant of Mortality in Congenital Diaphragmatic Hernia.

Patel N, Lally PA, Kipfmueller F, Massolo AC, Luco M, Van Meurs KP, Lally KP, Harting MT.

Am J Respir Crit Care Med. 2019 Dec 15;200(12):1522-1530. doi: 10.1164/rccm.201904-0731OC.

PMID: 31409095

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  1. Preoperative simulation for complex transposition of great arteries using a three-dimensional model.

Yokoyama S, Fukuba R, Mitani K, Uemura H.

Cardiol Young. 2019 Dec 13:1-3. doi: 10.1017/S1047951119002853. [Epub ahead of print]

PMID: 31831093

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  1. Double-outlet extension for narrowed retroaortic space.

Tarui S, Miyahara Y, Oyama N, Fujii T, Ishino K, Tomita H.

Asian Cardiovasc Thorac Ann. 2019 Dec 12:218492319896497. doi: 10.1177/0218492319896497. [Epub ahead of print] No abstract available.

PMID: 31830422

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  1. Thrombin Generation and Antithrombin Activity in Infants Undergoing Cardiopulmonary Bypass-An Exploratory Study.

Ashikhmina E, Johnson PM, Aganga DO, Nuttall GA, Lahr BD, Schaff HV, Dearani JA.

J Cardiothorac Vasc Anesth. 2019 Dec 11. pii: S1053-0770(19)31262-5. doi: 10.1053/j.jvca.2019.12.008. [Epub ahead of print]

PMID: 31901467

 

Select item 31823779

 

  1. Choice of shunt type for the Norwood I procedure: does it make a difference?

Vitanova K, Georgiev S, Lange R, Cleuziou J.

Interact Cardiovasc Thorac Surg. 2019 Dec 10. pii: ivz294. doi: 10.1093/icvts/ivz294. [Epub ahead of print]

PMID: 31821450

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  1. Improved Outcomes of Heart Transplantation in Adults With Congenital Heart Disease Receiving Regionalized Care.

Nguyen VP, Dolgner SJ, Dardas TF, Verrier ED, McMullan DM, Krieger EV.

J Am Coll Cardiol. 2019 Dec 10;74(23):2908-2918. doi: 10.1016/j.jacc.2019.09.062.

PMID: 31806135

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Select item 31821351

 

  1. Rationale and design of the STeroids to REduce Systemic inflammation after infant heart Surgery (STRESS) trial.

Hill KD, Baldwin HS, Bichel DP, Butts RJ, Chamberlain RC, Ellis AM, Graham EM, Hickerson J, Hornik CP, Jacobs JP, Jacobs ML, Jaquiss RD, Kannankeril PJ, O’Brien SM, Torok R, Turek JW, Li JS; STRESS Network Investigators.

Am Heart J. 2019 Dec 9;220:192-202. doi: 10.1016/j.ahj.2019.11.016. [Epub ahead of print]

PMID: 31855716

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  1. An unexpected association in a patient with heart failure presenting a surgical challenge.

Alegria S, Simões O, Almeida AR, Silva E Castro J, Laranjeira Á, Pereira H.

J Card Surg. 2019 Dec 9. doi: 10.1111/jocs.14393. [Epub ahead of print]

PMID: 31816112

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  1. Outcomes of the Warden Procedure for Partial Anomalous Pulmonary Venous Drainage.

Lin H, Yan J, Wang Q, Li S, Sun H, Zhang Y, Zhang L, Liu W.

Pediatr Cardiol. 2019 Dec 6. doi: 10.1007/s00246-019-02235-8. [Epub ahead of print]

PMID: 31811329

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  1. A unique indication for the senning procedure: Atrioventricular discordance with ventriculoarterial concordance.

Hermsen JL, Okorie UC, Srinivasan S, Schreiter NA, Anagnostopoulos PV.

J Card Surg. 2019 Dec 3. doi: 10.1111/jocs.14342. [Epub ahead of print]

PMID: 31793037

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  1. Impact of the 2016 revision of US Pediatric Heart Allocation Policy on waitlist characteristics and outcomes.

Magnetta DA, Godown J, West S, Zinn M, Rose-Felker K, Miller S, Feingold B.

Am J Transplant. 2019 Dec;19(12):3276-3283. doi: 10.1111/ajt.15567. Epub 2019 Sep 22.

PMID: 31544351

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  1. The Quest for Precision Medicine: Unmeasured Patient Factors and Mortality After Congenital Heart Surgery.

Pasquali SK, Gaies M, Banerjee M, Zhang W, Donohue J, Russell M, Gaynor JW.

Ann Thorac Surg. 2019 Dec;108(6):1889-1894. doi: 10.1016/j.athoracsur.2019.06.031. Epub 2019 Aug 6.

PMID: 31398358

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  1. Primary Transplantation for Congenital Heart Disease in the Neonatal Period: Long-term Outcomes.

John MM, Razzouk AJ, Chinnock RE, Bock MJ, Kuhn MA, Martens TP, Bailey LL.

Ann Thorac Surg. 2019 Dec;108(6):1857-1864. doi: 10.1016/j.athoracsur.2019.06.022. Epub 2019 Jul 27.

PMID: 31362016

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  1. Outcomes of Repair of Kommerell Diverticulum.

Vinnakota A, Idrees JJ, Rosinski BF, Tucker NJ, Roselli EE, Pettersson GB, Vekstein AM, Stewart RD, Raja S, Svensson LG.

Ann Thorac Surg. 2019 Dec;108(6):1745-1750. doi: 10.1016/j.athoracsur.2019.04.122. Epub 2019 Jun 27.

PMID: 31254511

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Select item 31085169

 

  1. Relief of Anteriorly Translocated Pulmonary Artery Compression With a Nuss Bar.

Kim H, Sung SC, Choi KH, Son BS, Doo Lee H, Kim G, Ko H.

Ann Thorac Surg. 2019 Dec;108(6):e397-e399. doi: 10.1016/j.athoracsur.2019.04.015. Epub 2019 May 11.

PMID: 31085169

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  1. Use of Idarucizumab to reverse the anticoagulant effect of dabigatran in cardiac transplant surgery. A multicentric experience in Spain.

Crespo-Leiro MG, López-Vilella R, López Granados A, Mirabet-Pérez S, Díez-López C, Barge-Caballero E, Segovia-Cubero J, González-Vilchez F, Rangel-Sousa D, Blasco-Peiró T, de la Fuente-Galán L, Díaz-Molina B, Zatarain-Nicolás E, Carrasco Ávalos F, Almenar-Bonet L.

Clin Transplant. 2019 Dec;33(12):e13748. doi: 10.1111/ctr.13748. Epub 2019 Nov 18.

PMID: 31670852

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  1. ADAPT-treated pericardium for aortic valve reconstruction in congenital heart disease: histological analysis of a series of human explants.

Nordmeyer S, Kretzschmar J, Murin P, Cho MY, Foth R, Schlichting U, Berger F, Ovroutski S, Photiadis J, Sigler M.

Eur J Cardiothorac Surg. 2019 Dec 1;56(6):1170-1177. doi: 10.1093/ejcts/ezz228.

PMID: 31504392

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  1. Risk factors for chylothorax and persistent serous effusions after congenital heart surgery.

Raatz A, Schöber M, Zant R, Cesnjevar R, Rüffer A, Purbojo A, Dittrich S, Alkassar M.

Eur J Cardiothorac Surg. 2019 Dec 1;56(6):1162-1169. doi: 10.1093/ejcts/ezz203.

PMID: 31292607

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  1. Elastica degeneration and intimal hyperplasia lead to Contegra® conduit failure.

Peivandi AD, Seiler M, Mueller KM, Martens S, Malec E, Asfour B, Lueck S.

Eur J Cardiothorac Surg. 2019 Dec 1;56(6):1154-1161. doi: 10.1093/ejcts/ezz199.

PMID: 31280306

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  1. Preoperative Feeds in Ductal-Dependent Cardiac Disease: A Systematic Review and Meta-analysis.

Kataria-Hale J, Osborne SW, Hair A, Hagan J, Pammi M.

Hosp Pediatr. 2019 Dec;9(12):998-1006. doi: 10.1542/hpeds.2019-0111. Review.

PMID: 31744846

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  1. A single stage approach to ascending aortic aneurysm and coarctation: Feasibility and challenges.

Das A, Kaul A, Khanuja JS.

J Card Surg. 2019 Dec;34(12):1635-1638. doi: 10.1111/jocs.14315. Epub 2019 Nov 5.

PMID: 31794129

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  1. Factors associated with perioperative mortality in children and adolescents operated for tetralogy of Fallot: A sub-Saharan experience.

Tefera E, Gedlu E, Nega B, Tadesse BT, Chanie Y, Dawoud A, Moges FH, Bezabih A, Moges T, Centella T, Marianeschi S, Coca A, Collado R, Kassa MW, Johansson S, van Doorn C, Barber BJ, Teodori M.

J Card Surg. 2019 Dec;34(12):1478-1485. doi: 10.1111/jocs.14270. Epub 2019 Oct 10.

PMID: 31600427

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  1. Preoperative cerebral and renal oxygen saturation and clinical outcomes in pediatric patients with congenital heart disease.

Saito J, Takekawa D, Kawaguchi J, Suganuma T, Konno M, Noguchi S, Tokita T, Hashiba E, Hirota K.

J Clin Monit Comput. 2019 Dec;33(6):1015-1022. doi: 10.1007/s10877-019-00260-9. Epub 2019 Jan 21.

PMID: 30666542

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  1. Time for evidence-based, standardized donor size matching for pediatric heart transplantation.

Riggs KW, Giannini CM, Szugye N, Woods J, Chin C, Moore RA, Morales DLS, Zafar F.

J Thorac Cardiovasc Surg. 2019 Dec;158(6):1652-1660.e4. doi: 10.1016/j.jtcvs.2019.06.037. Epub 2019 Jul 2.

PMID: 31353104

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  1. Surgical ventricular restoration and mitral valve replacement in a pediatric patient with complex congenital heart disease and malignant ventricular arrhythmias.

Saitto G, Castelvecchio S, Arcidiacono C, Menicanti L.

J Thorac Cardiovasc Surg. 2019 Dec;158(6):e189-e191. doi: 10.1016/j.jtcvs.2019.04.095. Epub 2019 Jun 14. No abstract available.

PMID: 31204132

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  1. Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice.

Zandstra TE, Palmen M, Hazekamp MG, Meyns B, Beeres SLMA, Holman ER, Kiès P, Jongbloed MRM, Vliegen HW, Egorova AD, Schalij MJ, Tops LF.

Neth Heart J. 2019 Dec;27(12):590-593. doi: 10.1007/s12471-019-01314-y. Review.

PMID: 31420818 Free PMC Article

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  1. [Pediatric coronary artery surgery. A new area in cardiac surgery?]

Hartyánszky I, Bogáts G.

Orv Hetil. 2019 Dec;160(49):1935-1940. doi: 10.1556/650.2019.31557. Review. Hungarian.

PMID: 31786939

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Select item 31262673

 

  1. Reabsorbable Pins can Reinforce an Early Sternal Stability After Median Sternotomy in Young Children with Congenital Heart Disease.

Fan C, Tang M, Wu S, Yuan S, Borovjagin AV, Yang J.

Pediatr Cardiol. 2019 Dec;40(8):1728-1734. doi: 10.1007/s00246-019-02212-1. Epub 2019 Sep 23.

PMID: 31549187

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Select item 31541264

 

  1. Effect of Trisomy 21 on Postoperative Length of Stay and Non-cardiac Surgery After Complete Repair of Tetralogy of Fallot.

Purifoy ET, Spray BJ, Riley JS, Prodhan P, Bolin EH.

Pediatr Cardiol. 2019 Dec;40(8):1627-1632. doi: 10.1007/s00246-019-02196-y. Epub 2019 Sep 7.

PMID: 31494702

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  1. Early Neurodevelopmental Outcomes in Children with Hypoplastic Left Heart Syndrome and Related Anomalies After Hybrid Procedure.

Khalid OM, Harrison TM.

Pediatr Cardiol. 2019 Dec;40(8):1591-1598. doi: 10.1007/s00246-019-02191-3. Epub 2019 Aug 30.

PMID: 31471627

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  1. Postoperative Inhaled Nitric Oxide Does Not Decrease Length of Stay in Pediatric Cardiac Surgery Admissions.

Wong J, Loomba RS, Evey L, Bronicki RA, Flores S.

Pediatr Cardiol. 2019 Dec;40(8):1559-1568. doi: 10.1007/s00246-019-02187-z. Epub 2019 Aug 24.

PMID: 31446473

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Select item 31453988

 

  1. Preoperative Physiology, Imaging, and Management of Coarctation of Aorta in Children.

Ganigara M, Doshi A, Naimi I, Mahadevaiah GP, Buddhe S, Chikkabyrappa SM.

Semin Cardiothorac Vasc Anesth. 2019 Dec;23(4):379-386. doi: 10.1177/1089253219873004. Epub 2019 Sep 19.

PMID: 31535945

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Select item 31431142

 

  1. Glial Fibrillary Acid Protein and Cerebral Oxygenation in Neonates Undergoing Cardiac Surgery.

Hansen JH, Kissner L, Chitadze G, Logoteta J, Jung O, Dütschke P, Attmann T, Scheewe J, Kramer HH.

Thorac Cardiovasc Surg. 2019 Dec;67(S 04):e11-e18. doi: 10.1055/s-0039-3401793. Epub 2019 Dec 31.

PMID: 31893463

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Select item 30964835

 

 

  1. Reduced Biventricular Volumes and Myocardial Dysfunction Long-term After Pediatric Heart Transplantation Assessed by CMR.

Latus H, Hachmann P, Voges I, Mueller S, Gummel K, Reich B, Sarikouch S, Peters B, Mazhari N, Behnke-Hall K, Jux C, Apitz C, Thul J, Akintuerk H, Bauer J, Schranz D.

Transplantation. 2019 Dec;103(12):2682-2691. doi: 10.1097/TP.0000000000002738.

PMID: 30964835

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Select item 30908816

 

  1. Motor outcome, executive functioning, and health-related quality of life of children, adolescents, and young adults after ventricular assist device and heart transplantation.

Barron LC, Haas N, Hagl C, Schulze-Neick I, Ulrich S, Lehner A, Heinen F, Weinberger R, Rosenthal L, Gerstl L, Dalla-Pozza R.

Pediatr Transplant. 2019 Dec 29:e13631. doi: 10.1111/petr.13631. [Epub ahead of print]

PMID: 31885156

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Select item 31885132

 

  1. Heterotaxy is not a risk factor for adverse long-term outcomes following Fontan completion.

Marathe SP, Zannino D, Cao JY, du Plessis K, Marathe SS, Ayer J, Celermajer DS, Gentles TL, Sholler GF, Justo RN, Alphonso N, d’Udekem Y, Winlaw DS.

Ann Thorac Surg. 2019 Dec 28. pii: S0003-4975(19)31974-5. doi: 10.1016/j.athoracsur.2019.11.015. [Epub ahead of print]

PMID: 31891693

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Select item 31883324

 

  1. Long-term therapeutic effect of Fontan conversion with an extracardiac conduit.

Hoashi T, Shimada M, Imai K, Komori M, Kurosaki K, Ohuchi H, Ichikawa H.

Eur J Cardiothorac Surg. 2019 Dec 28. pii: ezz355. doi: 10.1093/ejcts/ezz355. [Epub ahead of print]

PMID: 31883324

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Select item 31883238

 

  1. Use of the terminal complement inhibitor eculizumab in paediatric heart transplant recipients.

Law YM, Nandi D, Molina K, Gambetta K, Daly KP, Das B.

Cardiol Young. 2019 Dec 26:1-7. doi: 10.1017/S1047951119003056. [Epub ahead of print]

PMID: 31875805

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Select item 31875800

 

  1. Early weight trends after congenital heart surgery and their determinants.

Banerji N, Sudhakar A, Balachandran R, Sunil GS, Kotayil BP, Krishna Kumar R.

Cardiol Young. 2019 Dec 26:1-6. doi: 10.1017/S1047951119002944. [Epub ahead of print]

PMID: 31875790

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Select item 31876383

 

 

  1. Long-term follow-up after transatrial-transpulmonary repair of tetralogy of Fallot: influence of timing on outcome.

van den Bosch E, Bogers AJJC, Roos-Hesselink JW, van Dijk APJ, van Wijngaarden MHEJ, Boersma E, Nijveld A, Luijten LWG, Tanke R, Koopman LP, Helbing WA.

Eur J Cardiothorac Surg. 2019 Dec 23. pii: ezz331. doi: 10.1093/ejcts/ezz331. [Epub ahead of print]

PMID: 31872208

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Select item 31877391

 

  1. Novel Urinary Biomarkers for Acute Kidney Injury and Prediction of Clinical Outcomes After Pediatric Cardiac Surgery.

Yoneyama F, Okamura T, Takigiku K, Yasukouchi S.

Pediatr Cardiol. 2019 Dec 23. doi: 10.1007/s00246-019-02280-3. [Epub ahead of print]

PMID: 31872282

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Select item 31866580

 

  1. Postoperative Recovery of Left Ventricular Function following Repair of Large Ventricular Septal Defects in Infants.

Adamson GT, Arunamata A, Tacy TA, Silverman NH, Ma M, Maskatia SA, Punn R.

J Am Soc Echocardiogr. 2019 Dec 19. pii: S0894-7317(19)31051-X. doi: 10.1016/j.echo.2019.10.003. [Epub ahead of print]

PMID: 31866322

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Select item 31858202

 

  1. Midterm Outcomes of the Supported Ross Procedure in Children, Teenagers and Young Adults.

Riggs KW, Colohan DB, Beacher DR, Alsaied T, Powell S, Moore RA, Ginde S, Tweddell JS.

Semin Thorac Cardiovasc Surg. 2019 Dec 18. pii: S1043-0679(19)30391-0. doi: 10.1053/j.semtcvs.2019.10.020. [Epub ahead of print]

PMID: 31863831

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Select item 31845632

 

  1. Pseudoaneurysm of the aortic arch early after coarctation repair in the neonatal period.

Sousa AR, Teixeira AM, Neves JP.

Cardiol Young. 2019 Dec 16:1-3. doi: 10.1017/S1047951119002841. [Epub ahead of print]

PMID: 31840633

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  1. Association Between Post-procedure Intracardiac Pressures and the Use of Temporary Epicardial Pacing Wires After Pediatric Cardiac Surgery.

Haga T, Akamine Y, Yamamoto H, Kazuta T, Oba H, Iwata H, Otsuka Y, Ujiro A.

Pediatr Cardiol. 2019 Dec 13. doi: 10.1007/s00246-019-02268-z. [Epub ahead of print]

PMID: 31834463

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Select item 31834462

 

  1. Early changes in cell-free DNA levels in newly transplanted heart transplant patients.

Zangwill SD, Kindel SJ, Ragalie WS, North PE, Pollow A, Hidestrand M, Tomita-Mitchell A, Stamm KD, Mitchell ME.

Pediatr Transplant. 2019 Dec 11:e13622. doi: 10.1111/petr.13622. [Epub ahead of print]

PMID: 31825144

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Select item 31826021

 

  1. Application of modified bicaval technique for pediatric heart transplant with oversized donor heart.

Hoashi T, Sakaguchi H, Shimada M, Imai K, Komori M, Ichikawa H.

Gen Thorac Cardiovasc Surg. 2019 Dec 4. doi: 10.1007/s11748-019-01266-5. [Epub ahead of print]

PMID: 31802359

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  1. Posterior mitral leaflet extension using autologous pericardium to repair a hammock mitral valve associated with severe mitral valve regurgitation in a 4-month-old boy.

Maeda T, Fujiwara K, Yoshizawa K, Ishihara H, Sakazaki H.

Gen Thorac Cardiovasc Surg. 2019 Dec 3. doi: 10.1007/s11748-019-01262-9. [Epub ahead of print]

PMID: 31797212

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  1. A new era in pediatric heart allocation: Keeping our house in order.

Mao CY, Mahle WT.

Am J Transplant. 2019 Dec;19(12):3219-3220. doi: 10.1111/ajt.15596. Epub 2019 Nov 4. No abstract available.

PMID: 31529765

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Select item 31404546

 

  1. Early and Midterm Outcomes in High-risk Single-ventricle Patients: Hybrid Vs Norwood Palliation.

Sower CT, Romano JC, Yu S, Lowery R, Pasquali SK, Zampi JD.

Ann Thorac Surg. 2019 Dec;108(6):1849-1855. doi: 10.1016/j.athoracsur.2019.06.061. Epub 2019 Aug 9.

PMID: 31404546

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  1. The Quest for Precision Medicine: Unmeasured Patient Factors and Mortality After Congenital Heart Surgery.

Pasquali SK, Gaies M, Banerjee M, Zhang W, Donohue J, Russell M, Gaynor JW.

Ann Thorac Surg. 2019 Dec;108(6):1889-1894. doi: 10.1016/j.athoracsur.2019.06.031. Epub 2019 Aug 6.

PMID: 31398358

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Select item 31394091

 

  1. Surgical Repair of Ebstein’s Anomaly Using a Bicuspidization Approach.

Mainwaring RD, Rosenblatt TR, Lui GK, Ma M, Hanley FL.

Ann Thorac Surg. 2019 Dec;108(6):1875-1882. doi: 10.1016/j.athoracsur.2019.06.026. Epub 2019 Aug 5.

PMID: 31394091

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  1. Dacron Conduit for Extracardiac Total Cavopulmonary Anastomosis: A Word of Caution.

Careddu L, Petridis FD, Angeli E, Balducci A, Mariucci E, Egidy Assenza G, Donti A, Gargiulo GD.

Heart Lung Circ. 2019 Dec;28(12):1872-1880. doi: 10.1016/j.hlc.2018.11.005. Epub 2018 Dec 1.

PMID: 30555011

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  1. Valve-sparing repair with skeletonization of the pulmonary annulus for tetralogy of Fallot.

Türköz R, Doğan A, Oktay A, Saygılı A.

J Card Surg. 2019 Dec;34(12):1626-1628. doi: 10.1111/jocs.14252. Epub 2019 Sep 11.

PMID: 31508849

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  1. Time for evidence-based, standardized donor size matching for pediatric heart transplantation.

Riggs KW, Giannini CM, Szugye N, Woods J, Chin C, Moore RA, Morales DLS, Zafar F.

J Thorac Cardiovasc Surg. 2019 Dec;158(6):1652-1660.e4. doi: 10.1016/j.jtcvs.2019.06.037. Epub 2019 Jul 2.

PMID: 31353104

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  1. Autologous stem cell therapy for hypoplastic left heart syndrome: Safety and feasibility of intraoperative intramyocardial injections.

Burkhart HM, Qureshi MY, Rossano JW, Cantero Peral S, O’Leary PW, Hathcock M, Kremers W, Nelson TJ; Wanek HLHS Consortium Clinical Pipeline.

J Thorac Cardiovasc Surg. 2019 Dec;158(6):1614-1623. doi: 10.1016/j.jtcvs.2019.06.001. Epub 2019 Jun 7.

PMID: 31345560

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  1. Surgical ventricular restoration and mitral valve replacement in a pediatric patient with complex congenital heart disease and malignant ventricular arrhythmias.

Saitto G, Castelvecchio S, Arcidiacono C, Menicanti L.

J Thorac Cardiovasc Surg. 2019 Dec;158(6):e189-e191. doi: 10.1016/j.jtcvs.2019.04.095. Epub 2019 Jun 14. No abstract available.

PMID: 31204132

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  1. Personalised Warfarin Dosing in Children Post-cardiac Surgery.

Al-Metwali BZ, Rivers P, Goodyer L, O’Hare L, Young S, Mulla H.

Pediatr Cardiol. 2019 Dec;40(8):1735-1744. doi: 10.1007/s00246-019-02215-y. Epub 2019 Oct 5.

PMID: 31587090 Free PMC Article

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  1. Progression of Aortic Regurgitation After Subarterial Ventricular Septal Defect Repair: Optimal Timing of the Operation.

Jung H, Cho JY, Lee Y.

Pediatr Cardiol. 2019 Dec;40(8):1696-1702. doi: 10.1007/s00246-019-02206-z. Epub 2019 Sep 13.

PMID: 31520096 Free PMC Article

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  1. Effect of Trisomy 21 on Postoperative Length of Stay and Non-cardiac Surgery After Complete Repair of Tetralogy of Fallot.

Purifoy ET, Spray BJ, Riley JS, Prodhan P, Bolin EH.

Pediatr Cardiol. 2019 Dec;40(8):1627-1632. doi: 10.1007/s00246-019-02196-y. Epub 2019 Sep 7.

PMID: 31494702

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  1. Acute Change in Ventricular Contractility-Load Coupling After Corrective Surgery for Congenital Heart Defect: A Retrospective Cohort Study.

Oh J, Song IK, Cho J, Yun TJ, Park CS, Choi JM, Gwak M, Shin WJ.

Pediatr Cardiol. 2019 Dec;40(8):1618-1626. doi: 10.1007/s00246-019-02195-z. Epub 2019 Sep 3.

PMID: 31482237 Free PMC Article

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  1. Outcome for Conservative Surgery for the Correction of Severe Mitral Valve Regurgitation in Children: A Single-Center Experience.

Brancaccio G, Chinali M, Trezzi M, D’Anna C, Esposito C, Rinelli G, Vignaroli W, Albanese SB, Iorio FS, Carotti A.

Pediatr Cardiol. 2019 Dec;40(8):1663-1669. doi: 10.1007/s00246-019-02201-4. Epub 2019 Sep 3.

PMID: 31482236

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  1. Pediatric heart transplant from an incompletely treated influenza A-positive donor.

Smith CJ, McCulloch MD, Shirley DA, L’Ecuyer TJ.

Pediatr Transplant. 2019 Dec;23(8):e13585. doi: 10.1111/petr.13585. Epub 2019 Sep 12.

PMID: 31515860

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Fetal Cardiology Featured Articles

Fetal Cardiology Reviews of December 2019 Manuscripts

Fetal cardiac findings and hemodynamic changes associated with severe lower urinary tract obstruction in utero.

Cohen J, Levasseur S, Simpson L, Miller R, Freud L.

Ultrasound Obstet Gynecol. 2019 Dec;54(6):780-785. doi: 10.1002/uog.20271. Epub 2019 Nov 4.

PMID: 30908816

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Take Home Points:

  • Fetuses with lower urinary tract obstruction (LUTO) have a shorter indexed mitral valve inflow time and higher left ventricular myocardial performance index suggesting left ventricular dysfunction.
  • LUTO fetuses had higher right ventricular to left ventricular cardiac index ratio, which might explain the finding of smaller left-heart structures in a subset of fetuses with LUTO.

 

Commentary from Dr. Inga Voges (Kiel, Germany), section editor of Pediatric Cardiology Journal Watch:  Fetuses with lower urinary tract obstruction (LUTO) can develop cardiomegaly, cardiac hypertrophy and pericardial effusion. In this interesting retrospective study, the authors analyzed echocardiograms of a cohort of 25 fetuses with LUTO with a focus on ventricular function and hemodynamic assessment. 25 gestational age (GA)-matched control fetuses were included. Five patients had serial postnatal echocardiograms, that were analysed.

Fetuses with LUTO commonly presented with cardiomegaly, pericardial effusion as well as right and left ventricular (RV, LV) hypertrophy demonstrated by increased LV, RV and septal wall thickness. Six Fetuses had right ventricular dysfunction and four fetuses had small left-heart structures.

Myocardial performance index was significantly increased, and mitral valve inflow time indexed to cardiac cycle length was significantly reduced, both suggesting LV diastolic dysfunction. RV cardiac index was higher, and LV cardiac index was lower compared to controls, resulting in an increased RV to LV cardiac index ratio in LUTO fetuses. Ascending aortic and aortic isthmus z-scores were lower in LUTO fetuses compared to controls. See Table 2 and Figure 1.

During follow-up there were 17 liveborn patients; two of the 25 pregnancies were lost to follow-up, three had elective termination of pregnancy and there was intrauterine fetal demise in three cases.

One out of the four fetuses with small left-sided structures demised in utero. Two of the remaining three fetuses presented with slightly small left-sided structures postnatally that did not require any intervention, the third one was diagnosed with coarctation and died a few hours after birth due to respiratory distress. In those patients with serial postnatal echocardiograms, systolic function normalized by 3–10 days and ventricular hypertrophy normalized by 20 days to four months.

The authors nicely explain possible reasons for their finding of small left-heart structures (Figure 2) and hereby motivate others to perform future studies.

 

 

 

 

 

Impact of prospective measurement of outflow tracts in the prediction of coarctation of the aorta.

Vigneswaran TV, Zidere V, Chivers S, Charakida M, Akolekar R, Simpson JM.

Ultrasound Obstet Gynecol. 2019 Dec 25. doi: 10.1002/uog.21957. [Epub ahead of print]

PMID: 31875324

 

Take Home Points: 

 

  • Prenatal diagnosis of coarctation may be improved with routine measurement of the distal transverse arch and ductus arteriosus from the 3 vessel view
  • There is a high incidence of bicuspid aortic valve in patients with suspected, but not proven to have, coarctation.

 

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch:  Prenatal diagnosis of coarctation of the aorta (COA) is known to be quite difficult, with frequent false positives. There have been quite a few studies assessing various measurements to try to improve the diagnostic accuracy, but most are retrospective. It is known that prenatal diagnosis will improve morbidity and mortality, but false positives can have a negative psychological effect on the parents as well as prevent the initial infant/maternal bonding after birth.

This study  looked at cases of suspected COA between 15-36 GA who had at least 6 months of postnatal follow up, and who did not have any other major CHD. They used data from the time of the study (with the data set closest to 20 weeks GA to compute z-scores in patients with multiple studies). They measured the aortic and pulmonary valves in diastole at the maximal diameter, and the distal transverse aortic arch diameter (DTAA) and arterial duct (AD) in the 3 vessel view (3VT). They converted all measurements into z-scores that were derived from their own previously published data on 7000 normal fetuses. Of the 149 fetuses included in this study, 52% were confirmed to have COA within 6 months of age (most diagnosed in the neonatal period). Bicuspid aortic valve was identified after birth in 57% of the true COA group and 30% of the false positive group. A VSD was seen in both true and false positive cases. While aortic:pulmonary valve diameter ratio, DTAA diameter, 2nd trimester DTAA:AD ratio, AV z-score, DTAA z-score, and 2nd trimester z-score of the ratio of DTAA:AD were significantly smaller in the true COA group (see Table 1), logistic regression demonstrated that DTAA z-score and AD z-score were the only predictive variables. Table 3 shows the ROC curves for all variables and table 4 shows the sensitivity, specificity, PPV and NPV of the DTAA z-score.

A clear cut-off value for both DTAA z-score and the ratio were not provided, most likely given there is some overlap with a continued reasonably high (but better) false positive rate even when adding these measurements to the other published measurements in suspected COA. While a risk equation calculation was provided, lack of good cut-off values make it difficult for the individual sonographer and cardiologist to make decisions in real time based on their measurements. A few interesting features of the study include only using 3 vessel view measurements and not the sagittal aortic arch view, as well as the high frequency of BAV in the suspected COA group, which should likely affect prenatal counseling and should warrant further study.

 

Fetal cardiology and genetics Dec 2019

 

  1. Two case reports of fetal alcohol syndrome: broadening into the spectrum of cardiac disease to personalize and to improve clinical assessment.

Onesimo R, De Rose C, Delogu AB, Battista A, Leoni C, Veltri S, De Rosa G, Zampino G.

Ital J Pediatr. 2019 Dec 19;45(1):167. doi: 10.1186/s13052-019-0759-y.

PMID: 31856879 Free PMC Article

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  1. Expression of connexin-43 in the cardiac muscle of children diagnosed with hypoplastic left heart syndrome: a Western blot and confocal laser scanning microscopy study.

Lodi FR, Palma LF, de Victo NC, Alonso LG, de Moraes LOC.

Cardiol Young. 2019 Dec 17:1-5. doi: 10.1017/S104795111900297X. [Epub ahead of print]

PMID: 31845643

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  1. Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration.

Witman N, Zhou C, Grote Beverborg N, Sahara M, Chien KR.

Semin Cell Dev Biol. 2019 Dec 17. pii: S1084-9521(18)30295-7. doi: 10.1016/j.semcdb.2019.10.011. [Epub ahead of print] Review.

PMID: 31862220 Free Article

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  1. Genetics of Congenital Heart Disease.

Williams K, Carson J, Lo C.

Biomolecules. 2019 Dec 16;9(12). pii: E879. doi: 10.3390/biom9120879. Review.

PMID: 31888141 Free Article

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  1. TBX3 deficiency accelerates apoptosis in cardiomyoblasts through regulation of P21 expression.

Cao M, Zhu B, Sun Y, Zhao X, Qiu G, Fu W, Jiang H.

Life Sci. 2019 Dec 15;239:117040. doi: 10.1016/j.lfs.2019.117040. Epub 2019 Nov 6.

PMID: 31704448

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  1. Wnt Signaling: The double-edged sword diminishing the potential of stem cell therapy in congenital heart disease.

Mohamed IA, El-Badri N, Zaher A.

Life Sci. 2019 Dec 15;239:116937. doi: 10.1016/j.lfs.2019.116937. Epub 2019 Oct 17. Review.

PMID: 31629761

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  1. Comparison of fetal echocardiogram with fetal cardiac autopsy findings in fetuses with congenital heart disease.

Gao S, Han J, Yu S, Guo Y, Ruan Y, Fu Y, Hao X, Wang X, Wang S, Zhou X, Shang J, Zhang Y, Li T, Hao X, He Y.

J Matern Fetal Neonatal Med. 2019 Dec 12:1-7. doi: 10.1080/14767058.2019.1700498. [Epub ahead of print]

PMID: 31791182

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  1. Candidate modifier genes for immune function in 22q11.2 deletion syndrome.

Pinnaro CT, Henry T, Major HJ, Parida M, DesJardin LE, Manak JR, Darbro BW.

Mol Genet Genomic Med. 2019 Dec 12:e1057. doi: 10.1002/mgg3.1057. [Epub ahead of print]

PMID: 31830774 Free Article

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  1. Novel JAG1 Deletion Variant in Patient with Atypical Alagille Syndrome.

Micaglio E, Andronache AA, Carrera P, Monasky MM, Locati ET, Pirola B, Presi S, Carminati M, Ferrari M, Giamberti A, Pappone C.

Int J Mol Sci. 2019 Dec 11;20(24). pii: E6247. doi: 10.3390/ijms20246247.

PMID: 31835735 Free Article

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  1. In Vivo and In Vitro Genetic Models of Congenital Heart Disease.

Majumdar U, Yasuhara J, Garg V.

Cold Spring Harb Perspect Biol. 2019 Dec 9. pii: a036764. doi: 10.1101/cshperspect.a036764. [Epub ahead of print]

PMID: 31818859

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  1. Genetic Basis of Human Congenital Heart Disease.

Nees SN, Chung WK.

Cold Spring Harb Perspect Biol. 2019 Dec 9. pii: a036749. doi: 10.1101/cshperspect.a036749. [Epub ahead of print]

PMID: 31818857

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  1. Genetic and Epigenetic Control of Heart Development.

Akerberg BN, Pu WT.

Cold Spring Harb Perspect Biol. 2019 Dec 9. pii: a036756. doi: 10.1101/cshperspect.a036756. [Epub ahead of print]

PMID: 31818853

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  1. Functional genomics and gene-environment interaction highlight the complexity of Congenital Heart Disease caused by Notch pathway variants.

Chapman G, Moreau JLM, Ip E, Szot JO, Iyer KR, Shi H, Yam MX, O’Reilly VC, Enriquez A, Greasby JA, Alankarage D, Martin EMMA, Hanna BC, Edwards M, Monger S, Blue GM, Winlaw D, Ritchie HE, Grieve SM, Giannoulatou E, Sparrow DB, Dunwoodie SL.

Hum Mol Genet. 2019 Dec 9. pii: ddz270. doi: 10.1093/hmg/ddz270. [Epub ahead of print]

PMID: 31813956

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  1. Risk factors associated with fetal pleural effusion in prenatal diagnosis: a retrospective study in a single institute in Southern China.

Yang X, Yang D, Deng Q, Fang F, Han J, Zhen L, Li D, Liao C.

J Obstet Gynaecol. 2019 Dec 6:1-5. doi: 10.1080/01443615.2018.1503645. [Epub ahead of print]

PMID: 31809620

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  1. A Case of a Derivative Chromosome: der(Y)t(Y;18)Pat with Congenital Abnormalities.

Huang S, Xia Y, Ding H, Wang Y, Wu Y, Chen S, Zhuang J, Li P.

Fetal Pediatr Pathol. 2019 Dec 5:1-6. doi: 10.1080/15513815.2019.1695297. [Epub ahead of print]

PMID: 31805817

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  1. Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus.

Duan AQ, Darby JRT, Soo JY, Lock MC, Zhu MY, Flynn LV, Perumal SR, Macgowan CK, Selvanayagam JB, Morrison JL, Seed M.

Am J Physiol Regul Integr Comp Physiol. 2019 Dec 1;317(6):R780-R792. doi: 10.1152/ajpregu.00273.2017. Epub 2017 Dec 13.

PMID: 29351431

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  1. The Fetal 3-Vessel Views: An Illustrative Case-Based Tutorial.

Anton T, Sklansky MS, Perez M, Pretorius DH.

J Ultrasound Med. 2019 Dec;38(12):3335-3347. doi: 10.1002/jum.15067. Epub 2019 Jun 17. Review.

PMID: 31206762

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  1. Umbilical Cord Blood Gas in Newborns with Prenatal Diagnosis of Congenital Heart Disease: Insight into In-Utero and Delivery Hemodynamics.

Adams AD, Aggarwal N, Iqbal SN, Tague L, Skurow-Todd K, McCarter R, Donofrio MT.

Pediatr Cardiol. 2019 Dec;40(8):1575-1583. doi: 10.1007/s00246-019-02189-x. Epub 2019 Aug 30.

PMID: 31471626

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  1. Fetal cardiac findings and hemodynamic changes associated with severe lower urinary tract obstruction in utero.

Cohen J, Levasseur S, Simpson L, Miller R, Freud L.

Ultrasound Obstet Gynecol. 2019 Dec;54(6):780-785. doi: 10.1002/uog.20271. Epub 2019 Nov 4.

PMID: 30908816

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  1. Current and future role of fetal cardiovascular MRI in the setting of fetal cardiac interventions.

Marini D, Xu J, Sun L, Jaeggi E, Seed M.

Prenat Diagn. 2019 Dec 13. doi: 10.1002/pd.5626. [Epub ahead of print]

PMID: 31834624

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  1. Nomograms of Fetal Right Ventricular Fractional Area Change by 2D Echocardiography.

Guirado L, Crispi F, Soveral I, Valenzuela-Alcaraz B, Rodriguez-López M, García-Otero L, Torres X, Sepúlveda-Martínez Á, Escobar-Diaz MC, Martínez JM, Friedberg MK, Gratacós E, Gómez O.

Fetal Diagn Ther. 2019 Dec 10:1-12. doi: 10.1159/000503228. [Epub ahead of print]

PMID: 31822009

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  1. Cortical development in fetuses with congenital heart defects using an automated brain-age prediction algorithm.

Everwijn SMP, Namburete AIL, van Geloven N, Jansen FAR, Papageorghiou AT, Noble AJ, Teunissen AKK, Rozendaal L, Blom NA, van Lith JMM, Haak MC.

Acta Obstet Gynecol Scand. 2019 Dec;98(12):1595-1602. doi: 10.1111/aogs.13687. Epub 2019 Aug 24.

PMID: 31322290

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  1. Merged bilateral arterial duct and circumflex retroesophageal right aortic arch in a fetus with normal intracardiac anatomy.

Bichali S, Grigorescu RC, Lefebvre M, Oriot C, Dhombres F, Bonnet D, Houyel L.

Cardiol Young. 2019 Dec;29(12):1546-1548. doi: 10.1017/S1047951119002488. Epub 2019 Nov 4.

PMID: 31679548

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  1. Two Cases of a Prenatally Diagnosed Double Aortic Arch with Postnatal Obliteration of the Distal Left Aortic Arch.

Doan TT, Wang A, Davey B, Upadhyay S, Toro-Salazar O.

Pediatr Cardiol. 2019 Dec;40(8):1748-1751. doi: 10.1007/s00246-019-02141-z. Epub 2019 Jun 24.

PMID: 31236613

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  1. Fetal cardiac findings and hemodynamic changes associated with severe lower urinary tract obstruction in utero.

Cohen J, Levasseur S, Simpson L, Miller R, Freud L.

Ultrasound Obstet Gynecol. 2019 Dec;54(6):780-785. doi: 10.1002/uog.20271. Epub 2019 Nov 4.

PMID: 30908816

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Congenital Heart Anesthesia and Intensive Care

CHD anesthesia Dec 2019

  1. Benefits of ultra-fast-track anesthesia for children with congenital heart disease undergoing cardiac surgery.

Xu J, Zhou G, Li Y, Li N.

BMC Pediatr. 2019 Dec 11;19(1):487. doi: 10.1186/s12887-019-1832-9.

PMID: 31829170 Free PMC Article

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  1. Fifty Percent Effective Dose of Intranasal Dexmedetomidine Sedation for Transthoracic Echocardiography in Children With Cyanotic and Acyanotic Congenital Heart Disease.

Yang F, Li S, Shi Y, Liu L, Ye M, Zhang J, Liu H, Liu F, Yu Q, Sun M, Tian Q, Tu S.

J Cardiothorac Vasc Anesth. 2019 Dec 6. pii: S1053-0770(19)31209-1. doi: 10.1053/j.jvca.2019.11.037. [Epub ahead of print]

PMID: 31899144

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  1. Management of a parturient with uncorrected tetralogy of Fallot in shock: an anesthetic challenge.

Bellapukonda S, Roncall BR, Mund M.

BMJ Case Rep. 2019 Dec 2;12(12). pii: e231517. doi: 10.1136/bcr-2019-231517.

PMID: 31796458

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  1. Deep Tracheal Extubation Using Dexmedetomidine in Children With Congenital Heart Disease Undergoing Cardiac Catheterization: Advantages and Complications.

Gautam NK, Bober K, Pierre JA, Pawelek O, Griffin E.

Semin Cardiothorac Vasc Anesth. 2019 Dec;23(4):387-392. doi: 10.1177/1089253219870628. Epub 2019 Aug 20.

PMID: 31431142

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Select item 31431128

 

  1. Anesthesia for Pediatric Heart Transplantation: Are Patients With a Failing Hemi-Fontan- or Fontan-Physiology Different?

Mueller MF, Paul AC, Mann V, Koerner CM, Valeske K, Thul J, Mazhari N, Bauer J, Schranz D, Akintuerk H.

Semin Cardiothorac Vasc Anesth. 2019 Dec;23(4):393-398. doi: 10.1177/1089253219870635. Epub 2019 Aug 20.

PMID: 31431128

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  1. Highlights of Current Research in Congenital Heart Disease: Presenting Abstracts From the 2019 Congenital Cardiac Anesthesia Society (CCAS) Annual Meeting.

Latham GJ.

Semin Cardiothorac Vasc Anesth. 2019 Dec;23(4):349-351. doi: 10.1177/1089253219867696. Epub 2019 Aug 8. No abstract available.

PMID: 31390945

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  1. Achieving Sustainability in Reducing Unplanned Extubations in a Pediatric Cardiac ICU.

Censoplano NM, Barrett CS, Ing RJ, Reichert K, Rannie M, Kaufman J.

Pediatr Crit Care Med. 2019 Dec 3. doi: 10.1097/PCC.0000000000002193. [Epub ahead of print]

PMID: 31688673

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  1. Anesthesia, Sedation, and Pain Control.

Hamrick SEG, Ing C.

Clin Perinatol. 2019 Dec;46(4):xvii-xviii. doi: 10.1016/j.clp.2019.09.002. Epub 2019 Sep 12. No abstract available.

PMID: 31653313

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  1. Postoperative Inhaled Nitric Oxide Does Not Decrease Length of Stay in Pediatric Cardiac Surgery Admissions.

Wong J, Loomba RS, Evey L, Bronicki RA, Flores S.

Pediatr Cardiol. 2019 Dec;40(8):1559-1568. doi: 10.1007/s00246-019-02187-z. Epub 2019 Aug 24.

PMID: 31446473

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The CHIP Network Journal Watch Team

Konstantin Averin, MD, MS is an Associate Professor of Pediatrics at the University of Alberta and an Interventional Pediatric Cardiologist at the Stollery Children’s Hospital in Edmonton, Alberta. He received his medical degree from the Feinberg School of Medicine at Northwestern University in Chicago, IL. After medical school, he completed pediatrics residency, pediatric cardiology fellowship and sub-specialty training in pediatric and adult interventional cardiology at the Cincinnati Children’s Hospital in Cincinnati, OH. His clinical and research interests are focused on the percutaneous treatment of pediatric patients with congenital and acquired heart disease with a focus on patients with single ventricle physiology, transcatheter pulmonary valves, and pulmonary hypertension.

Dr. Leong Ming Chern “MC” is an adult congenital heart disease specialist at the National Heart Institute, Kuala Lumpur, Malaysia. He received his medical training at the University of Malaya and pediatric cardiology training at the National Heart Institute. His area of interest includes treatment of adult patients with congenital heart disease and pulmonary hypertension in congenital heart disease.

Dr. Damien Cullington, MBChB MRCP MD FESC is a consultant adult congenital cardiologist who works at Leeds General Infirmary, UK. In summer 2019, he will move over to the newly commissioned North West ACHD Service based in Liverpool, UK. Damien qualified in 2002 from the University of Liverpool and became a substantive consultant in 2016. Prior to this, he worked throughout the North of England and Yorkshire as a cardiology trainee. Damien was awarded a doctorate in medicine (MD) from the University of Hull in 2013 for his work in heart rate in patients with heart failure. He is a member of the Royal College of Physicians (London), Fellow of the European Society of Cardiology and honorary senior lecturer for the University of Leeds. His ACHD subspecialty clinical interests are heart failure, imaging and palliative care. He is regional organiser for ACHD training at Leeds and clinical governance lead for the Leeds congenital cardiac unit. His research interests and wide and far but particularly epidemiology, chronic heart failure in ACHD patients in all its guises, the systemic RV and the univentricle

Dr. Blanche Cupido is a consultant adult cardiologist working at Groote Schuur Hospital, UCT Private Academic Hospital and the University of Cape Town(UCT), South Africa. She completed her physician training in 2009 and her cardiology subspecialist training in 2013. She recently returned to SA after doing a Fellowship in Adult Congenital Heart Disease in Leeds, United Kingdom under the guidance of Dr Kate English. She has established a dedicated unit for Grown Up Congenital Heart Disease in Cape Town, South Africa. Her aim is to grow ACHD services in Sub-Saharan Africa and embark on GUCH research on the African continent.

Dr. Jeremy L. Herrmann is an Assistant Professor of Surgery in the Division of Thoracic and Cardiovascular Surgery at Indiana University. He specializes in pediatric and adult congenital cardiac surgery, and his clinical interests also include heart transplantation and mechanical circulatory support. His hospital affiliations include Indiana University Health Riley Hospital for Children and Methodist Hospital as well as Peyton Manning Children’s Hospital at St. Vincent Hospital in Indianapolis

Maan Jokhadar is a cardiologist and associate professor of medicine at Emory University in Atlanta, Georgia. He is board certified in internal medicine, cardiovascular disease, advanced heart failure/transplantation, adult congenital heart disease, and echocardiography. He is fellowship director for the Emory Adult Congenital Heart Disease training program and Core Curriculum Director for the Emory general cardiology fellowship program. Dr Jokhadar graduated from the University Damascus School of Medicine in Syria and then went to Mayo Clinic in Rochester, Minnesota for internal medicine residency. He then completed cardiology and subspecialty training at Emory University, where he currently on faculty. Dr. Jokhadar has been the recipient of numerous teaching awards. He is married with 3 children.

Michael Ma, MD is an Assistant Professor in Cardiothoracic Surgery in the Division of Pediatric Cardiac Surgery at Stanford University. He specializes in pediatric and adult congenital cardiac surgery, with an emphasis on neonates, complex biventricular repair, and pulmonary artery reconstruction. His research lab investigates ex and in vivo translational models for complex congenital heart disease, to optimize future surgical and endovascular repair strategies.

Jeremy P. Moore MD MS FHRS is the Director of Clinical Research and faculty in Pediatric Cardiology and Adult Congenital Heart Disease at the University of California, Los Angeles. Dr. Moore received his medical degree from the Medical College of Virginia in 2003. He completed residency and fellowship at UCLA before pursuing his subspecialty training in Pediatric Electrophysiology at Vanderbilt University in 2009. Dr. Moore has been faculty at UCLA since 2010 and has since published numerous research manuscripts dealing with electrophysiologic aspects pertinent to congenital heart disease. Dr. Moore’s primary interest is the study of mechanisms of arrhythmia, and the development of novel electrophysiologic techniques for management of the adult patient with congenital heart disease

Dr. Mehul Patel MD, is a structural and adult congenital heart disease specialist and an interventional cardiologist. Dr. Patel earned his undergraduate and medical education from the Mumbai University, India. After completing his post-graduate training in Internal Medicine and Cardiology, he further trained in interventional cardiology at the Mount Sinai Medical Center, NYC, NY and Adult Congenital Heart Disease at the Texas Children’s Hospital, Texas Heart Institute, Baylor College of Medicine, Houston, TX. Dr. Patel worked as Chief of adult congenital heart disease, Assistant Professor at the Michigan State University, Grand Rapids, MI where he not only expanded the program, performing complex interventions and device implantations but also established the percutaneous pulmonary valve implantation (Melody Valve) Program. Due to his passion for treating structurally abnormal hearts, he did a dedicated year of Structural Heart Disease fellowship at Henry Ford Hospital, Detroit, MI where he worked with pioneers in this field before moving to North Carolina. He is proficient in performing transcatheter aortic valve replacement (TAVR), MitraClip, Watchman device implantation, percutaneous Mitral, Tricuspid and Pulmonary valve replacements along with a variety of interventions on congenital heart disease and pulmonary hypertension. Dr. Patel is ABIM board certified in Internal Medicine, Cardiology, Interventional cardiology and Adult Congenital Heart Disease. Dr. Patel has more than 50 peer reviewed publications and numerous abstracts to his credit. He serves as a Co-Editor-in-Chief for the CHiP Network journal watch. His wife, Khyati is a pediatric cardiac Electrophysiologist and they have a 9-year-old daughter. Dr. Patel is also an artist, likes music, yoga and plays badminton. His clinical areas of expertise and interests are: 1) Transcatheter therapies for Structural and Adult Congenital heart disease. 2) Complex device implantations.

Dr. Timothy Pirolli is an Assistant Professor of Surgery in the Division of Pediatric Cardiothoracic Surgery at University of Texas Southwestern Medical Center. He specializes in pediatric and adult congenital cardiac surgery. His hospital affiliations include Children’s Medical Center in Dallas, Parkland Memorial Hospital, and Clements University Hospital (UTSW).

Dr. Inga Voges, M.D. Consultant in Pediatric Cardiology, Lead Consultant Cardiovascular MRI. I trained in General Pediatrics and Pediatric Cardiology in Rostock (Germany) and Kiel (Germany) from 2002-2010 and did additional training in Adult Congenital Heart Disease (ACHD) in Kiel (Germany) which I finished in 2014. I specialized in Cardiovascular Magnetic Resonance Imaging (CMR) and have a further special interest in cardiomyopathies. Currently, I am working as a consultant pediatric and ACHD cardiologist at the University Hospital Schleswig-Holstein (Kiel, Germany) where I am responsible for the CMR imaging program in pediatric and ACHD patients and contribute to the care of patients with acquired and congenital heart disease. I received my MD from the Medical University Luebeck in 2006 (Germany) and finished my “Habilitation” (PhD equivalent; University Hospital Kiel, Germany) in 2014. Since 2016, I am the secretary of the Association for European Paediatric and Congenital Cardiology Imaging Working Group.

Dr. Gary Webb, M.D. is an Emeritus Professor of Pediatrics and Internal Medicine at the University of Cincinnati College of Medicine and,
from 2009-2016, the Director of the Adult Congenital Heart Program at Cincinnati Children’s Hospital Heart Institute. A graduate of McGill
University in Montréal, he interned at the Royal Victoria Hospital, and then trained in internal medicine and cardiology at the University of Toronto. From 1980-2004, he was co-director and then director of the Toronto Congenital Cardiac Center for Adults at Toronto General Hospital. He is a Fellow of the Royal College of Physicians and Surgeons of Canada in both internal medicine and cardiology. From 2004-2009, he was director of the Philadelphia Adult Congenital Heart Center at the University of Pennsylvania. Since 2016, he has been a consultant to Cincinnati Children’s Hospital, and has been responsible for the ACHD Learning Center, the Cardiology Fellow Testing Center, and the Congenital Heart Professionals International (CHIP) Network. Since 2017, he has resumed seeing patients on a part-time basis at the Toronto Congenital Cardiac Centre for Adults.

Wendy Whiteside, MD Wendy is Assistant Professor of Pediatrics and Associate Director of Interventional Pediatric Cardiology at the University of Michigan Congenital Heart Center, C.S. Mott Children’s Hospital. She obtained her medical degree from Albert Einstein College of Medicine in 2006 then completed pediatric residency at Children’s Hospital Oakland in Oakland, CA in 2009. She received
both her categorical and interventional pediatric cardiology training at the University of Michigan in Ann Arbor, MI. Her clinical and research interests include single ventricle physiology, transcatheter
pulmonary valves, and quality improvement within the cardiac catheterization laboratory.

About the Congenital Heart and Pediatric Cardiac Journal Watch

Congenital heart and pediatric cardiac Journal Watch was designed to make it easier for congenital heart and pediatric cardiac professionals to keep up with the literature in 6 subsections of congenital heart disease abstracts on a monthly basis: pediatric cardiology; congenital heart surgery; congenital  heart interventions; congenital/pediatric electrophysiology; fetal cardiology; and adult congenital heart disease.

We encourage your continued support as well as your valuable comments and feedback.

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Sincerely,

Dr. Gary Webb, MD and Dr. Mehul Patel
CHiP Network
Congenital Heart and Pediatic Cardiac Journal Watch Editorial Board

The Chip Network, the Congenital Heart International Professionals Network, aims to develop a single global list of all congenital and pediatric cardiac professionals.

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