CHiP Network Congenital Heart Journal Watch – April 2019

Pediatric Cardiology Featured Articles

Pediatric Cardiology Reviews of February 2019 Manuscripts

Mortality and Resource Use Following Cardiac Interventions in Children with Trisomy 13 and Trisomy 18 and Congenital Heart Disease.

Domingo L, Carey JC, Eckhauser A, Wilkes J, Menon SC.

Pediatr Cardiol. 2019 Feb;40(2):349-356. doi: 10.1007/s00246-018-2001-x. Epub 2018 Oct 5.

PMID: 30291384

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Take Home Points:

  • As expected, overall resource use is higher for patients with T13 and T18 who undergo surgery for cardiac lesions.
  • T13 had a higher mortality, tracheostomies, and gastrostomies than T18.
  • While there is increased risk for morbidity and mortality in this patient population, outcomes may be reasonable for a select cohort to undergo cardiac intervention. 

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal WatchIntervention, especially cardiac surgery, for patients with Trisomy 13 (T13) and Trisomy 18 (T18), has historically rarely been considered or offered due to a high 1 year mortality rate. There seems to be some change in practice over the past few years, possibly influenced by parental desire to “do everything” when these patients are carried to term. As a majority of patients will have CHD, cardiologists are often intimately involved beginning in fetal life. Recent surveys have shown practice variabilities amongst different groups of physicians (e.g. neonatologists vs. cardiologists), but also depending on the type of cardiac lesion. This study was done to describe the clinical outcomes and resource use in those patients who underwent cardiac intervention using a large multicenter database of 45 pediatric hospitals. 

Data included demographics, ICD-9 coding, and resource utilization information. Children were excluded if they had additional genetic defects, admitted for non-cardiac indication, or older than age 5 at the time of first cardiac intervention. CHD was categorized as a shunt lesion, left-sided obstruction, conotruncal defect, or single ventricle physiology. Interventions including diagnostic and catheter based interventions, palliative procedures, or complete surgical repair. RACHS and other demographic and historical information were reviewed. Mortality and resource use (total hospital charges adjusted to 2014 US Dollars) were the primary outcomes.

189 patients with T13 and T18 underwent cardiac intervention between 1999-2015. 26% had T13 and 74% T18. There were 238 hospitalizations for cardiac interventions, with 18% of T13 and 14% of T18 undergoing more than one intervention. A higher number of T13 had a tracheostomy or G-tube than T18 (12% vs. 4% and 18% vs. 6%, respectively). Shunt and conotruncal lesions were most common in both groups, but more T13 patients had single ventricle physiology.  The majority of interventions were complete surgical repairs. 40% of the interventions occurred in the south US region, with more than half on government insurance. (See Table 1).

T18 patients were significantly older than T13 patients at time of initial intervention (5 vs. 2.5 months). T13 had longer median hospital LOS, but this was not statistically significant. Total median hospital charge was $305,990 for T13 and $252,780 for T18 (also not statistically significant). Mortality rate following surgery was high for both groups, but significantly higher in T13 (29% vs. 12%). Overall in-hospital mortality between groups was not statistically significant (T13 33% and T18 22%). (See Table 2). Regression modeling showed improved survival for white race in T13 patients and older age at initial intervention for T18. Tracheostomy or other comorbidities, cardiopulmonary bypass, type of cardiac lesion, and type of intervention did not affect postprocedural survival. 

The authors note that ~70% of patients overall were discharged home with improved symptoms, suggesting a clear clinical benefit for a majority of patients. Compared to previous studies, the age at initial intervention was younger, suggesting a shift towards more aggressive medical intervention. The data also show a clear trend towards complete repair than palliative repair in the US.  However, median costs were 1.5-2 times more and hospital LOS 2-3 times longer than those without these trisomies. While type of lesion was not associated with survival, the numbers are probably too low for some lesions to affect current decision making processes in most institutions (e.g. not intervening or palliating for single ventricle lesions). This data though could possibly suggest a benefit to intervening for some lesions if the costs and morbidity are acceptable. Additionally, long-term survival and quality of life data in those who underwent intervention have not yet been elucidated, so individual treatment plans and ethics teams will likely be necessary as we move forward. However, this study should hopefully lead to more discussion at pediatric hospitals as to how best to manage this challenging patient population.

  1. Impact of Initial Shunt Type on Echocardiographic Indices in Children After Single Right Ventricle Palliations.

Frommelt PC, Hu C, Trachtenberg F, Baffa JM, Boruta RJ, Chowdhury S, Cnota JF, Dragulescu A, Levine JC, Lu J, Mercer-Rosa L, Miller TA, Shah A, Slesnick TC, Stapleton G, Stelter J, Wong P, Newburger JW.

Circ Cardiovasc Imaging. 2019 Feb;12(2):e007865. doi: 10.1161/CIRCIMAGING.118.007865.

PMID:  30755054

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Take Home Points:

 

  • Shunt type has no significant impact on echocardiographic indices of right ventricle, neoaortic, and tricuspid valve size and function after the first palliation by 6 years of life.
  • Decreases in RV function present in the RV to pulmonary artery shunt seen in the previous SVR trial were no longer present, suggesting ongoing RV remodeling with time.
  • Future incorporation of this data with newer echo modalities, MRI results, and quality of life measures (self-reported or even exercise testing data as these patients get older) may give us even more beneficial data for this population. 

Commentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Pediatric Cardiology Journal Watch:  This is the most recent update from the Pediatric Heart Network SVR trial comparing 549 infants with single RV anomalies randomly assigned to a modified Blalock-Taussig shunt (MBTS) or RV to pulmonary artery shunt (RVPAS) at 15 centers in North America. The goal was to determine if shunt type was associated with better clinical outcome. Previous SVR trial articles showed a better 1 year transplant free survival in the RVPAS group, but this survivor benefit was no longer present at 3 years of life. Similarly, the early improved RV ejection fraction (RVEF) in the RVPAS group diminished over time, and in fact, at 3 years, the RVEF was worse in the RVPAS compared to the MBTS group.

This surveillance time point included those patients who had an echocardiogram performed within 6 months of Fontan palliation and at 6 years of life. 2D and Doppler indices of RV size and function were assessed, as well as neoaortic and tricuspid valve size and function. Exclusions included patients who underwent cardiac transplantation, a few who had biventricular repair, and those that did not consent to the extension trial. The specific echocardiographic and core lab procedures were described in earlier reports and unchanged for this study.

241 studies were analyzed with 116 MBTS and 125 RVPAS; 208 of those at undergone a pre-Fontan echo and 228 also had an acceptable echo at 14 months. In the overall cohort at the 6 year compared to the pre-Fontan echo, RV systolic and diastolic volumes and indexed areas decreased significantly, and RVEF, FAC, and peak tricuspid annular systolic velocity increased significantly (Table 2). When compared to the 14 month study, 6 year RV systolic and diastolic volume was significantly decreased, but RVEF increased nonsignificantly (P=0.06). When comparing interval changes by group, RVEF and FAC increased significantly in the RVPAS group vs. the MBTS group (Figure 2).  There was an increase in MPI by PW Doppler (and not by tissue Doppler) over time (14 month to post-Fontan), but no difference at 6 years between groups. However, the increase was only significant for the MBTS group when comparing pre-Fontan and 6 years.

Neoaortic annular areas were larger in MBTS vs. RVPAS, but both were significant large compared to normal (z-score 6.4 and 5.4 respectively). Greater than mild regurgitation was rare and similar between groups. There was a significant decrease in size when comparing the 14 month and 6 year studies (no difference from pre-Fontan to 6 years). Indexed tricuspid annular areas and z-scores were similar in both groups at 6 years. Greater than moderate TR occurred in 17% of subjects in each group. There was significant decrease in annular size between 14 months and 6 years, but no difference from pre-Fontan to 6 years.

The authors also evaluated the 14 month RVEF and the relationship to late death/transplant. There were 43 deaths/transplants in the 337 patients who had 14 month echocardiograms. Decreased RVEF (<40%) had a hazard ratio of 3.18 for death/transplant. Shunt type had no effect.

This study at 6 years of follow up shows no difference in outcomes (echocardiographic and clinical) between shunt groups. Based on changes at this time point vs. the earlier time point, RV remodeling has occurred resulting in equivocal RV systolic and diastolic function regardless of shunt type. There have been concerns about the RV ventriculotomy and resultant injury/scarring potentially affecting RV performance, but this was not seen by 6 years. Additionally, the RVPAS group showed a similar survival/transplant free rate to the MBTS group at 6 years, despite the initial lower death/transplant-free survival benefit up to stage 2, and then an increase in death until the Fontan, showing that there was some beneficial change that occurred with time particularly in this group. The study confirms the lack of significant neoaortic and tricuspid valve issues in this younger age cohort, even with the marked increase in annular size compared to normal patients. Additionally, RVEF < 40% at 14 months remains a significant risk factor for death/transplant. It is important to note that the RVPAS group had a significantly higher incidence of catheter-based interventions, and it is possible that the improved hemodynamics may have contributed to the improved RV function. Multiple required interventions may have a “familial” and quality of life affect that has not been assessed.

Limitations of the study were clearly delineated. RV function is very difficult to evaluate in general by echo, and in particular in those with a single RV. Rudimentary LV mechanical effects on the single RV were also not assessed (and typically cannot be when only using echocardiographic tools). The addition of newer echocardiographic modalities such as strain and 3D assessment of the tricuspid valve, as well as MRI data, may be very helpful moving forward. There is some discussion that MRI data will be included in the next follow up report as the patients reach 10-12 years of age.

An accompanying editorial provides an additional question that is important to consider. Are there outcomes besides RV function that should be assessed? Health related quality of life measures and a better assessment of functional status (patient and parental reporting as well as future exercise data as these patients get older and are able to be tested on a cycle ergometer or treadmill) may provide a better functional insight into how these patients are over time. 

Table 2 

 

 

Pediatric cardiology Feb 2019

 

  1. Dynamic Three-Dimensional Geometry of the Tricuspid Valve Annulus in Hypoplastic Left Heart Syndrome with a Fontan Circulation.

Nguyen AV, Lasso A, Nam HH, Faerber J, Aly AH, Pouch AM, Scanlan AB, McGowan FX, Mercer-Rosa L, Cohen MS, Simpson J, Fichtinger G, Jolley MA.

J Am Soc Echocardiogr. 2019 Feb 27. pii: S0894-7317(19)30002-1. doi: 10.1016/j.echo.2019.01.002. [Epub ahead of print]

PMID: 30826226

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  1. Equine Congenital Heart Disease.

Scansen BA.

Vet Clin North Am Equine Pract. 2019 Feb 27. pii: S0749-0739(18)30069-5. doi: 10.1016/j.cveq.2018.11.001. [Epub ahead of print] Review.

PMID: 30826104

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  1. Breastfeeding and vitamin D supplementation reduce the risk of Kawasaki disease in a German population-based case-control study.

Meyer K, Volkmann A, Hufnagel M, Schachinger E, Klau S, Horstmann J, Berner R, Fischer M, Lehner A, Haas N, Ulrich S, Jakob A.

BMC Pediatr. 2019 Feb 26;19(1):66. doi: 10.1186/s12887-019-1438-2.

PMID: 30808315 Free Article

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  1. Trisomy of the Short Arm of Chromosome 12 Associated with High Cardiovascular Risk: A Case Report.

Fulcheri C, Balietti P, Rabbia F, Schiavone D, Magnino C, Abate Daga F, Gollin M, Veglio F.

High Blood Press Cardiovasc Prev. 2019 Feb 26. doi: 10.1007/s40292-019-00307-7. [Epub ahead of print]

PMID: 30806948

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  1. EXPRESS: Parameters associated with outcome in pediatric patients with congenital heart disease and pulmonary hypertension subjected to combined vasodilator and surgical treatments.

Thomaz AM, Kajita LJ, Aiello VD, Zorzanelli L, Galas FR, Machado CG, Barbero-Marcial M, Jatene MB, Rabinovitch M, Lopes AA.

Pulm Circ. 2019 Feb 26:2045894019837885. doi: 10.1177/2045894019837885. [Epub ahead of print] No abstract available.

PMID: 30806154

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  1. A De novo HDAC2 variant in a patient with features consistent with Cornelia de Lange syndrome phenotype.

Wagner VF, Hillman PR, Britt AD, Ray JW, Farach LS.

Am J Med Genet A. 2019 Feb 25. doi: 10.1002/ajmg.a.61101. [Epub ahead of print]

PMID: 30806031

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  1. Status of Pediatric Cardiac Care in Developing Countries.

Saxena A.

Children (Basel). 2019 Feb 25;6(2). pii: E34. doi: 10.3390/children6020034. Review.

PMID: 30823591 Free Article

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  1. Long-term outcomes in 3 cases of quadricuspid aortic valve, using a new classification system: A case series and literature review.

Tsugu T, Murata M, Endo J, Kawakami T, Tsuruta H, Itabashi Y, Fukuda K.

Echocardiography. 2019 Feb 25. doi: 10.1111/echo.14278. [Epub ahead of print]

PMID: 30803004

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  1. Visualization of coronary arteries in paediatric patients using whole-heart coronary magnetic resonance angiography: comparison of image-navigation and the standard approach for respiratory motion compensation.

Velasco Forte MN, Valverde I, Prabhu N, Correia T, Narayan SA, Bell A, Mathur S, Razavi R, Hussain T, Pushparajah K, Henningsson M.

J Cardiovasc Magn Reson. 2019 Feb 25;21(1):13. doi: 10.1186/s12968-019-0525-8.

PMID: 30798789 Free Article

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  1. Hypoplastic Left Heart Syndrome: A New Paradigm for an Old Disease?

Grossfeld P, Nie S, Lin L, Wang L, Anderson RH.

J Cardiovasc Dev Dis. 2019 Feb 23;6(1). pii: E10. doi: 10.3390/jcdd6010010. Review.

PMID: 30813450 Free Article

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  1. Clinical spectrum of previously undiagnosed pediatric cardiac disease.

Fisher JD, Bechtel RJ, Siddiqui KN, Nelson DG, Nezam A.

Am J Emerg Med. 2019 Feb 22. pii: S0735-6757(19)30113-5. doi: 10.1016/j.ajem.2019.02.029. [Epub ahead of print]

PMID: 30833044

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  1. Association of maternal disease and medication use with the risk of congenital heart defects in offspring: a case-control study using logistic regression with a random-effects model.

Lai T, Xiang L, Liu Z, Mu Y, Li X, Li N, Li S, Chen X, Yang J, Tao J, Zhu J.

J Perinat Med. 2019 Feb 22. pii: /j/jpme.ahead-of-print/jpm-2018-0281/jpm-2018-0281.xml. doi: 10.1515/jpm-2018-0281. [Epub ahead of print]

PMID: 30794526

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  1. Contemporary outcomes and mortality risks of Ebstein anomaly: A single-center experience in Thailand.

Pornprasertchai V, Vijarnsorn C, Kanjanauthai S, Chungsomprasong P, Chanthong P, Durongpisitkul K, Soongswang J.

Congenit Heart Dis. 2019 Feb 21. doi: 10.1111/chd.12759. [Epub ahead of print]

PMID: 30791188

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  1. Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies.

Liu Y, Chen S, Zühlke L, Black GC, Choy MK, Li N, Keavney BD.

Int J Epidemiol. 2019 Feb 19. pii: dyz009. doi: 10.1093/ije/dyz009. [Epub ahead of print]

PMID: 30783674

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  1. Outcomes related to respiratory syncytial virus with an abbreviated palivizumab regimen in children with congenital heart disease: a descriptive analysis.

Claydon J, Popescu CR, Shaiba L, Christopherson C, Human D, Taylor R, Solimano A, Lavoie PM.

CMAJ Open. 2019 Feb 18;7(1):E88-E93. doi: 10.9778/cmajo.20180167. Print 2019 Jan-Mar.

PMID: 30782771 Free PMC Article

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  1. Evaluation and Monitoring of Pulmonary Hypertension in Neonates With Congenital Diaphragmatic Hernia.

Sanchez Mejia AA, Rodgers NJ.

Curr Treat Options Cardiovasc Med. 2019 Feb 15;21(2):11. doi: 10.1007/s11936-019-0711-x. Review.

PMID: 30767157

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  1. Prelude to “Pediatric and Congenital Heart Disease”.

Singh GK.

Curr Treat Options Cardiovasc Med. 2019 Feb 15;21(2):9. doi: 10.1007/s11936-019-0716-5. Review. No abstract available.

PMID: 30767074

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  1. Maternal obesity and gestational diabetes: Impact on arterial wall layer thickness and stiffness in early childhood – RADIEL study six-year follow-up.

Sundholm JKM, Litwin L, Rönö K, Koivusalo SB, Eriksson JG, Sarkola T.

Atherosclerosis. 2019 Feb 12. pii: S0021-9150(19)30064-4. doi: 10.1016/j.atherosclerosis.2019.01.037. [Epub ahead of print]

PMID: 30819513

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  1. Human Neonatal Thymus Mesenchymal Stem/Stromal Cells and Chronic Right Ventricle Pressure Overload.

Chery J, Huang S, Gong L, Wang S, Yuan Z, Wong J, Lee J, Johnson S, Si MS.

Bioengineering (Basel). 2019 Feb 9;6(1). pii: E15. doi: 10.3390/bioengineering6010015.

PMID: 30744090 Free Article

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  1. Actions in Support of Newborn Screening for Critical Congenital Heart Disease – United States, 2011-2018.

Glidewell J, Grosse SD, Riehle-Colarusso T, Pinto N, Hudson J, Daskalov R, Gaviglio A, Darby E, Singh S, Sontag M.

MMWR Morb Mortal Wkly Rep. 2019 Feb 8;68(5):107-111. doi: 10.15585/mmwr.mm6805a3.

PMID: 30730872 Free PMC Article

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  1. Clinical and mutation profile of pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: results from a Chinese cohort.

Chen H, Li X, Liu X, Wang J, Zhang Z, Wu J, Huang M, Guo Y, Li F, Wang X, Fu L.

Orphanet J Rare Dis. 2019 Feb 7;14(1):29. doi: 10.1186/s13023-019-1010-z.

PMID: 30732632 Free PMC Article

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  1. Neonatal Skin-to-Skin Contact: Implications for Learning and Autonomic Nervous System Function in Infants With Congenital Heart Disease.

Harrison TM, Chen CY, Stein P, Brown R, Heathcock JC.

Biol Res Nurs. 2019 Feb 5:1099800419827599. doi: 10.1177/1099800419827599. [Epub ahead of print]

PMID: 30722675

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  1. Physiologic diagnosis of congenital heart disease in cyanotic neonates.

Desai K, Rabinowitz EJ, Epstein S.

Curr Opin Pediatr. 2019 Feb 5. doi: 10.1097/MOP.0000000000000742. [Epub ahead of print]

PMID: 30730315

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  1. [Current situation of the organisation, resources and activity in paediatric cardiology in Spain].

Sánchez Ferrer F, Castro García FJ, Pérez-Lescure Picarzo J, Roses Noguer F, Centeno Malfaz F, Grima Murcia MD, Brotons DA.

An Pediatr (Barc). 2019 Feb;90(2):94-101. doi: 10.1016/j.anpedi.2018.03.004. Epub 2018 Apr 26. Spanish.

PMID: 29706438 Free Article

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  1. [Overweight and obesity in children treated for congenital heart disease].

Perin F, Carreras Blesa C, Rodríguez Vázquez Del Rey MDM, Cobo I, Maldonado J.

An Pediatr (Barc). 2019 Feb;90(2):102-108. doi: 10.1016/j.anpedi.2018.03.005. Spanish.

PMID: 29691131 Free Article

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  1. Affairs of the heart, does congenital heart disease make you happier?

Klaassen RJ.

Arch Dis Child. 2019 Feb;104(2):105. doi: 10.1136/archdischild-2018-315401. Epub 2018 Jul 30. No abstract available.

PMID: 30061201

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  1. How to use saturation monitoring in newborns.

McVea S, McGowan M, Rao B.

Arch Dis Child Educ Pract Ed. 2019 Feb;104(1):35-42. doi: 10.1136/archdischild-2017-313499. Epub 2018 May 10.

PMID: 29748228

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  1. Usefulness of diluted contrast medium for test-scanning of infants scheduled for contrast-enhanced cardiovascular computed tomography angiography.

Masuda T, Funama Y, Nakaura T, Sato T, Tahara M, Matsumoto Y, Imada N, Miyazaki O, Awai K.

Br J Radiol. 2019 Feb;92(1094):20180572. doi: 10.1259/bjr.20180572. Epub 2018 Nov 14.

PMID: 30412445

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  1. The mysterious “double” arch.

Gopalakrishnan A, Sivasubramonian S, Valaparambil A.

Echocardiography. 2019 Feb;36(2):422-423. doi: 10.1111/echo.14253. Epub 2019 Jan 9.

PMID: 30628131

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  1. Transition from tube feeding to oral feeding: experience in a tertiary care paediatric cardiology unit.

Shine AM, Finn DG, Allen N, McMahon CJ.

Ir J Med Sci. 2019 Feb;188(1):201-208. doi: 10.1007/s11845-018-1812-3. Epub 2018 May 2. Erratum in: Ir J Med Sci. 2018 Jun 29;:.

PMID: 29717418

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  1. A new anatomic approach of the ventricular septal defect in the interruption of the aortic arch.

Mostefa Kara M, Houyel L, Bonnet D.

J Anat. 2019 Feb;234(2):193-200. doi: 10.1111/joa.12911. Epub 2018 Dec 7.

PMID: 30525196

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  1. Mosaic trisomy 22 in a 4-year-old boy with congenital heart disease and general hypotrophy: A case report.

Kalayinia S, Shahani T, Biglari A, Maleki M, Rokni-Zadeh H, Razavi Z, Mahdieh N.

J Clin Lab Anal. 2019 Feb;33(2):e22663. doi: 10.1002/jcla.22663. Epub 2018 Sep 26.

PMID: 30259573

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  1. Sildenafil Use in Children with Pulmonary Hypertension.

Cohen JL, Nees SN, Valencia GA, Rosenzweig EB, Krishnan US.

J Pediatr. 2019 Feb;205:29-34.e1. doi: 10.1016/j.jpeds.2018.09.067. Epub 2018 Nov 2.

PMID: 30396684

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  1. Need for Routine Screening of Health-Related Quality of Life in Families of Young Children with Complex Congenital Heart Disease.

Denniss DL, Sholler GF, Costa DSJ, Winlaw DS, Kasparian NA.

J Pediatr. 2019 Feb;205:21-28.e2. doi: 10.1016/j.jpeds.2018.09.037. Epub 2018 Oct 23.

PMID: 30366775

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  1. Social Risk Factors Impact Hospital Readmission and Outpatient Appointment Adherence for Children with Congenital Heart Disease.

Demianczyk AC, Behere SP, Thacker D, Noeder M, Delaplane EA, Pizarro C, Sood E.

J Pediatr. 2019 Feb;205:35-40.e1. doi: 10.1016/j.jpeds.2018.09.038. Epub 2018 Oct 23.

PMID: 30366772

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  1. Bidirectional flow across a perforate cor triatriatum dexter in a dog with concurrent pulmonary, tricuspid, and mitral valve dysplasia.

Hokanson CM, Rhinehart JD, Scansen BA.

J Vet Cardiol. 2019 Feb;21:93-97. doi: 10.1016/j.jvc.2018.12.002. Epub 2019 Jan 25.

PMID: 30797449

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  1. Anatomical anomalies and variations of main thoracic vessels in dogs: a computed tomography study.

Sebastian-Marcos P, Fonfara S, Borgeat K, Warren-Smith C, Casamian-Sorrosal D.

J Vet Cardiol. 2019 Feb;21:57-66. doi: 10.1016/j.jvc.2018.08.005. Epub 2018 Dec 13.

PMID: 30797446

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  1. User-Friendly Vendor-Specific Guideline for Pediatric Cardiothoracic Computed Tomography Provided by the Asian Society of Cardiovascular Imaging Congenital Heart Disease Study Group: Part 1. Imaging Techniques.

Hong SH, Goo HW, Maeda E, Choo KS, Tsai IC; Asian Society of Cardiovascular Imaging Congenital Heart Disease Study Group.

Korean J Radiol. 2019 Feb;20(2):190-204. doi: 10.3348/kjr.2018.0571. Review.

PMID: 30672159 Free PMC Article

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  1. Birth Location of Infants with Critical Congenital Heart Disease in California.

Purkey NJ, Axelrod DM, McElhinney DB, Rigdon J, Qin F, Desai M, Shin AY, Chock VY, Lee HC.

Pediatr Cardiol. 2019 Feb;40(2):310-318. doi: 10.1007/s00246-018-2019-0. Epub 2018 Nov 10.

PMID: 30415381

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  1. Effect of Congenital Heart Disease Status on Trends in Pediatric Infective Endocarditis Hospitalizations in the United States Between 2000 and 2012.

Dolgner SJ, Arya B, Kronman MP, Chan T.

Pediatr Cardiol. 2019 Feb;40(2):319-329. doi: 10.1007/s00246-018-2020-7. Epub 2018 Nov 10.

PMID: 30415379

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  1. Mortality and Resource Use Following Cardiac Interventions in Children with Trisomy 13 and Trisomy 18 and Congenital Heart Disease.

Domingo L, Carey JC, Eckhauser A, Wilkes J, Menon SC.

Pediatr Cardiol. 2019 Feb;40(2):349-356. doi: 10.1007/s00246-018-2001-x. Epub 2018 Oct 5.

PMID: 30291384

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  1. Variation in Adjusted Mortality for Medical Admissions to Pediatric Cardiac ICUs.

Gaies M, Ghanayem NS, Alten JA, Costello JM, Lasa JJ, Chanani NK, Shin AY, Retzloff L, Zhang W, Pasquali SK, Banerjee M, Tabbutt S.

Pediatr Crit Care Med. 2019 Feb;20(2):143-148. doi: 10.1097/PCC.0000000000001751.

PMID: 30371635

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  1. The value of peripheral perfusion index measurements for early detection of critical cardiac defects.

Uygur O, Koroglu OA, Levent E, Tosyali M, Akisu M, Yalaz M, Kultursay N.

Pediatr Neonatol. 2019 Feb;60(1):68-73. doi: 10.1016/j.pedneo.2018.04.003. Epub 2018 Apr 12.

PMID: 29776787 Free Article

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  1. Case 262: Isolated Left Ventricular Apical Hypoplasia.

Schapiro AH, Rattan MS, Moore RA, Dillman JR.

Radiology. 2019 Feb;290(2):569-573. doi: 10.1148/radiol.2019161902.

PMID: 30673498

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  1. Risk factors for situs defects and congenital heart disease in primary ciliary dyskinesia.

Best S, Shoemark A, Rubbo B, Patel MP, Fassad MR, Dixon M, Rogers AV, Hirst RA, Rutman A, Ollosson S, Jackson CL, Goggin P, Thomas S, Pengelly R, Cullup T, Pissaridou E, Hayward J, Onoufriadis A, O’Callaghan C, Loebinger MR, Wilson R, Chung EM, Kenia P, Doughty VL, Carvalho JS, Lucas JS, Mitchison HM, Hogg C.

Thorax. 2019 Feb;74(2):203-205. doi: 10.1136/thoraxjnl-2018-212104. Epub 2018 Aug 30.

PMID: 30166424

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Select item 30820431

 

  1. Identifying best practices in interstage care: using a positive deviance approach within the National Pediatric Cardiology Quality Improvement Collaborative.

Bates KE, Yu S, Mangeot C, Shea JA, Brown DW, Uzark K.

Cardiol Young. 2019 Feb 26:1-10. doi: 10.1017/S1047951118002548. [Epub ahead of print]

PMID: 30806343

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Select item 30784676

 

  1. Bad Atrioventricular Valve, Bad Fontan: Stop Creating Bad Fontans.

Cetta F, Driscoll DJ.

J Am Coll Cardiol. 2019 Feb 26;73(7):823-825. doi: 10.1016/j.jacc.2018.12.026. No abstract available.

PMID: 30784676

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Select item 30817920

 

  1. Comparison of chloral hydrate and pentobarbital sedation for pediatric echocardiography.

Ganigara M, Srivastava S, Malik P, Fong S, Ko H, Parness I, Shenoy R.

Echocardiography. 2019 Feb 25. doi: 10.1111/echo.14301. [Epub ahead of print]

PMID: 30803010

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Select item 30803005

 

  1. Noncompaction-like membranous structure in left ventricle.

Ceylan O, Arman D, Kara N.

Echocardiography. 2019 Feb 25. doi: 10.1111/echo.14294. [Epub ahead of print]

PMID: 30803005

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Select item 30802937

 

  1. Noncompaction-like membranous structure in left ventricle.

Ceylan O, Arman D, Kara N.

Echocardiography. 2019 Feb 25. doi: 10.1111/echo.14294. [Epub ahead of print]

PMID: 30803005

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Select item 30802937

 

  1. Localization and age distribution of telangiectases in children and adolescents with hereditary hemorrhagic telangiectasia: A retrospective cohort study.

Gonzalez CD, Cipriano SD, Topham CA, Stevenson DA, Whitehead KJ, Vanderhooft S, Presson AP, McDonald J.

J Am Acad Dermatol. 2019 Feb 25. pii: S0190-9622(18)32903-7. doi: 10.1016/j.jaad.2018.11.014. [Epub ahead of print]

PMID: 30819528

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Select item 30804174

 

  1. Coronary artery lesion risk and mediating mechanism in children with complete and incomplete Kawasaki disease.

Shi H, Qiu H, Jin Z, Li C, Yang X, Huang C, Wu R, Zhuang G, Chu M.

J Investig Med. 2019 Feb 25. pii: jim-2018-000898. doi: 10.1136/jim-2018-000898. [Epub ahead of print]

PMID: 30804174

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Select item 30183667

 

  1. Clinical spectrum of previously undiagnosed pediatric cardiac disease.

Fisher JD, Bechtel RJ, Siddiqui KN, Nelson DG, Nezam A.

Am J Emerg Med. 2019 Feb 22. pii: S0735-6757(19)30113-5. doi: 10.1016/j.ajem.2019.02.029. [Epub ahead of print]

PMID: 30833044

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Select item 30796334

 

  1. The Fate of the Outflow Tract Septal Complex in Relation to the Classification of Ventricular Septal Defects.

Anderson RH, Tretter JT, Spicer DE, Mori S.

J Cardiovasc Dev Dis. 2019 Feb 21;6(1). pii: E9. doi: 10.3390/jcdd6010009. Review.

PMID: 30795606 Free Article

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Select item 30790093

 

  1. Diagnosis of anomalous origin of the right coronary artery from the pulmonary artery by echocardiography.

Wu LP, Zhang YQ, Chen LJ, Liu YQ.

J Med Ultrason (2001). 2019 Feb 21. doi: 10.1007/s10396-019-00933-7. [Epub ahead of print]

PMID: 30790093

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Select item 30789653

 

  1. Why do we break one of the first rules of anatomy when describing the components of the heart?

De Almeida MC, Spicer DE, Anderson RH.

Clin Anat. 2019 Feb 20. doi: 10.1002/ca.23356. [Epub ahead of print] Review. No abstract available.

PMID: 30786071

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Select item 30785656

 

  1. Reference values for two-dimensional myocardial strain echocardiography of the left ventricle in healthy children.

Koopman LP, Rebel B, Gnanam D, Menting ME, Helbing WA, Boersma E.

Cardiol Young. 2019 Feb 19:1-13. doi: 10.1017/S1047951118002378. [Epub ahead of print]

PMID: 30777588

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Select item 30784161

 

  1. Pediatric Cardio-Oncology: Epidemiology, Screening, Prevention, and Treatment.

Chow EJ, Leger KJ, Bhatt NS, Mulrooney DA, Ross CJ, Aggarwal S, Bansal N, Ehrhardt MJ, Armenian SH, Scott JM, Hong B.

Cardiovasc Res. 2019 Feb 15. pii: cvz031. doi: 10.1093/cvr/cvz031. [Epub ahead of print]

PMID: 30768157

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Select item 30770669

 

  1. Arterial Stiffness and Its Relationship to Cardiorespiratory Fitness in Children and Young Adults with a Fontan Circulation.

Noortman LCM, Haapala EA, Takken T.

Pediatr Cardiol. 2019 Feb 15. doi: 10.1007/s00246-019-02065-8. [Epub ahead of print]

PMID: 30770935

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Select item 30770863

 

  1. Phenotype of CM-AVM2 caused by variants in EPHB4: how much overlap with hereditary hemorrhagic telangiectasia (HHT)?

Wooderchak-Donahue WL, Akay G, Whitehead K, Briggs E, Stevenson DA, O’Fallon B, Velinder M, Farrell A, Shen W, Bedoukian E, Skrabann CM, Antaya RJ, Henderson K, Pollak J, Treat J, Day R, Jacher JE, Hannibal M, Bontempo K, Marth G, Bayrak-Toydemir P, McDonald J.

Genet Med. 2019 Feb 14. doi: 10.1038/s41436-019-0443-z. [Epub ahead of print]

PMID: 30760892

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Select item 30763368

 

  1. Modifiable Clinical Correlates of Vascular Health in Children and Adolescents with Dyslipidemia.

White DA, Anand GM, Qayum O, Ibezim CF, Sherman AK, Raghuveer G.

Pediatr Cardiol. 2019 Feb 13. doi: 10.1007/s00246-019-02071-w. [Epub ahead of print]

PMID: 30759268

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Select item 30758519

 

  1. A complex case of aortic arch interruption and hypoplastic descending aorta.

Pérez-Andreu J, Fernández-Doblas J, Giralt García G, Roses F, Abella RF.

Asian Cardiovasc Thorac Ann. 2019 Feb 12:218492318804948. doi: 10.1177/0218492318804948. [Epub ahead of print]

PMID: 30754985

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Select item 30819513

 

 

  1. A complex case of aortic arch interruption and hypoplastic descending aorta.

Pérez-Andreu J, Fernández-Doblas J, Giralt García G, Roses F, Abella RF.

Asian Cardiovasc Thorac Ann. 2019 Feb 12:218492318804948. doi: 10.1177/0218492318804948. [Epub ahead of print]

PMID: 30754985

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Select item 30819513

 

  1. Systematic literature review on the economic, humanistic, and societal burden of heart failure in children and adolescents.

Burch M, Nallagangula TK, Nic Lochlainn E, Severin T, Thakur L, Jaecklin T, George AT, Solar-Yohay S, Rossano JW, Shaddy RE.

Expert Rev Pharmacoecon Outcomes Res. 2019 Feb 12:1-12. doi: 10.1080/14737167.2019.1579645. [Epub ahead of print]

PMID: 30747011

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Select item 30759782

 

  1. The closing process of the ductus arteriosus connecting the left common carotid artery and main pulmonary artery.

Matsuo K, Aoki H, Kayatani F.

Cardiol Young. 2019 Feb 11:1-3. doi: 10.1017/S1047951118002275. [Epub ahead of print]

PMID: 30739622

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Select item 30747084

 

  1. Comprehensive Noninvasive Evaluation of Right Ventricle-Pulmonary Circulation Axis in Pediatric Patients with Pulmonary Hypertension.

Jone PN, Ivy DD.

Curr Treat Options Cardiovasc Med. 2019 Feb 9;21(1):6. doi: 10.1007/s11936-019-0710-y. Review.

PMID: 30739224

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Select item 30735477

 

  1. Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis.

Matundan HH, Sin J, Rivas MN, Fishbein MC, Lehman TJ, Chen S, Gottlieb RA, Crother TR, Abe M, Arditi M.

JCI Insight. 2019 Feb 7;4(3). pii: 126279. doi: 10.1172/jci.insight.126279. [Epub ahead of print]

PMID: 30728329 Free Article

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Select item 30733433

 

  1. Size and Stiffness of the Pulmonary Autograft after the Ross Procedure in Children.

Ando Y, Ochiai Y, Tokunaga S, Hisahara M, Baba H, Miyagi C, Takigawa T.

Pediatr Cardiol. 2019 Feb 7. doi: 10.1007/s00246-019-02064-9. [Epub ahead of print]

PMID: 30734094

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Select item 30729261

 

  1. Serum Exosomal microRNA Let-7i-3p as Candidate Diagnostic Biomarker for Kawasaki Disease Patients with Coronary Artery Aneurysm.

Wang YF, Lian XL, Zhong JY, Su SX, Xu YF, Xie XF, Wang ZP, Li W, Zhang L, Che D, Yu L, Huang P, Jia HL, Gu XQ.

IUBMB Life. 2019 Feb 6. doi: 10.1002/iub.2015. [Epub ahead of print]

PMID: 30724444

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Select item 30738657

 

  1. Pulmonary Hypertension Secondary to Scurvy in a Developmentally Typical Child.

Frank BS, Runciman M, Manning WA, Ivy DD, Abman SH, Howley L.

J Pediatr. 2019 Feb 6. pii: S0022-3476(19)30020-4. doi: 10.1016/j.jpeds.2018.12.068. [Epub ahead of print] No abstract available.

PMID: 30738657

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Select item 30726509

 

  1. Non-invasive Hemodynamic CMR Parameters Predicting Maximal Exercise Capacity in 54 Patients with Ebstein’s Anomaly.

Meierhofer C, Kühn A, Müller J, Shehu N, Hager A, Martinoff S, Stern H, Ewert P, Vogt M.

Pediatr Cardiol. 2019 Feb 6. doi: 10.1007/s00246-019-02066-7. [Epub ahead of print]

PMID: 30726509

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Select item 30728445

 

  1. Physiologic diagnosis of congenital heart disease in cyanotic neonates.

Desai K, Rabinowitz EJ, Epstein S.

Curr Opin Pediatr. 2019 Feb 5. doi: 10.1097/MOP.0000000000000742. [Epub ahead of print]

PMID: 30730315

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Select item 30726890

 

  1. [Diagnostic recommendation for myocarditis in children (version 2018)].

Subspecialty Group of Cardiology, the Society of Pediatrics, Chinese Medical Association; Collaborating Group of Myocarditis, the Subspecialty Group of Cardiology, the Society of Pediatrics, Chinese Medical Association; Editorial Board, Chinese Journal of Pediatrics; Pediatric Cardiology Committee, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association.

Zhonghua Er Ke Za Zhi. 2019 Feb 2;57(2):87-89. doi: 10.3760/cma.j.issn.0578-1310.2019.02.004. Chinese.

PMID: 30695879

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Select item 30503800

 

  1. Characterization of Left Ventricular Dysfunction by Myocardial Strain in Critical Pulmonary Stenosis and Pulmonary Atresia After Neonatal Pulmonary Valve Balloon Dilation.

Ronai C, Ghelani SJ, Marshall AC, Harrild DM, Gauvreau K, Colan SD, Brown DW.

Am J Cardiol. 2019 Feb 1;123(3):454-459. doi: 10.1016/j.amjcard.2018.10.025. Epub 2018 Nov 6.

PMID: 30503800

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Select item 30499712

 

  1. Fontan-Associated Liver Disease: Evidence for Early Surveillance of Liver Health in Pediatric Fontan Patients.

Rathgeber SL, Harris KC.

Can J Cardiol. 2019 Feb;35(2):217-220. doi: 10.1016/j.cjca.2018.11.019. Epub 2018 Nov 29.

PMID: 30760429

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Select item 30785385

 

  1. How do diet and exercise programmes affect the cardiovascular risk profiles of obese children?

Karaağaç AT, Yıldırım Aİ.

Cardiol Young. 2019 Feb;29(2):200-205. doi: 10.1017/S1047951118002093. Epub 2019 Feb 1.

PMID: 30704544

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Select item 30501652

 

  1. A cardiac hydatid cyst mimicking a pericardial tumour in a paediatric case.

Oner T, Korun O, Celebi A.

Cardiol Young. 2019 Feb;29(2):244-246. doi: 10.1017/S1047951118002032. Epub 2018 Dec 4.

PMID: 30511599

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Select item 30511598

 

  1. Impact of Initial Shunt Type on Echocardiographic Indices in Children After Single Right Ventricle Palliations.

Frommelt PC, Hu C, Trachtenberg F, Baffa JM, Boruta RJ, Chowdhury S, Cnota JF, Dragulescu A, Levine JC, Lu J, Mercer-Rosa L, Miller TA, Shah A, Slesnick TC, Stapleton G, Stelter J, Wong P, Newburger JW.

Circ Cardiovasc Imaging. 2019 Feb;12(2):e007865. doi: 10.1161/CIRCIMAGING.118.007865.

PMID: 30755054

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Select item 30755052

 

  1. Shunts and the Single Right Ventricle.

Kutty S, Danford DA.

Circ Cardiovasc Imaging. 2019 Feb;12(2):e008711. doi: 10.1161/CIRCIMAGING.118.008711. No abstract available.

PMID: 30755052

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Select item 30704282

 

  1. Submillisievert Multiphasic Coronary Computed Tomography Angiography for Pediatric Patients With Congenital Heart Diseases.

Le Roy J, Vernhet Kovacsik H, Zarqane H, Vincenti M, Abassi H, Lavastre K, Mura T, Lacampagne A, Amedro P.

Circ Cardiovasc Imaging. 2019 Feb;12(2):e008348. doi: 10.1161/CIRCIMAGING.118.008348.

PMID: 30704282

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Select item 30649896

 

  1. Velocity vector imaging for the assessment of segmental ventricular function in children with a single right ventricle after cavopulmonary anastomosis.

Chen LJ, Zhang YQ, Bao SF, Zhong SW, Sun AM, Zhang ZF.

Curr Med Res Opin. 2019 Feb;35(2):203-210. doi: 10.1080/03007995.2018.1460337. Epub 2018 May 10.

PMID: 29611724

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Select item 30527913

 

  1. Aortopulmonary window in tetralogy of Fallot with absent conal septum.

Aurigemma D, Dixon C, Tucker S, Davis C, Silverman N.

Echocardiography. 2019 Feb;36(2):411-414. doi: 10.1111/echo.14243. Epub 2018 Dec 25.

PMID: 30585348

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Select item 29933438

 

  1. Feasibility of clinical hypnosis for transesophageal echocardiography in children and adolescents.

Amedro P, Gavotto A, Gelibert D, Fraysse V, De La Villeon G, Vandenberghe D, Bredy C.

Eur J Cardiovasc Nurs. 2019 Feb;18(2):163-170. doi: 10.1177/1474515118803513. Epub 2018 Sep 19.

PMID: 30230358

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Select item 30291340

 

  1. Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability.

Verheije R, Kupchik GS, Isidor B, Kroes HY, Lynch SA, Hawkes L, Hempel M, Gelb BD, Ghoumid J, D’Amours G, Chandler K, Dubourg C, Loddo S, Tümer Z, Shaw-Smith C, Nizon M, Shevell M, Van Hoof E, Anyane-Yeboa K, Cerbone G, Clayton-Smith J, Cogné B, Corre P, Corveleyn A, De Borre M, Hjortshøj TD, Fradin M, Gewillig M, Goldmuntz E, Hens G, Lemyre E, Journel H, Kini U, Kortüm F, Le Caignec C, Novelli A, Odent S, Petit F, Revah-Politi A, Stong N, Strom TM, van Binsbergen E; DDD study, Devriendt K, Breckpot J.

Eur J Hum Genet. 2019 Feb;27(2):278-290. doi: 10.1038/s41431-018-0281-5. Epub 2018 Oct 5.

PMID: 30291340

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Select item 30679989

 

  1. An update on current and emerging treatments for pulmonary arterial hypertension in childhood and adolescence.

Wacker J, Weintraub R, Beghetti M.

Expert Rev Respir Med. 2019 Feb;13(2):205-215. doi: 10.1080/17476348.2019.1565998. Epub 2019 Jan 11.

PMID: 30614292

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Select item 30158136

 

  1. Development of suction force during early diastole from the left atrium to the left ventricle in infants, children, and adolescents.

Takahashi K, Nii M, Takigiku K, Toyono M, Iwashima S, Inoue N, Tanaka N, Matsui K, Shigemitsu S, Yamada M, Kobayashi M, Yazaki K, Itatani K, Shimizu T.

Heart Vessels. 2019 Feb;34(2):296-306. doi: 10.1007/s00380-018-1239-9. Epub 2018 Aug 28.

PMID: 30155660

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  1. Global strain and dyssynchrony of the single ventricle predict adverse cardiac events after the Fontan procedure: Analysis using feature-tracking cine magnetic resonance imaging.

Ishizaki U, Nagao M, Shiina Y, Inai K, Mori H, Takahashi T, Sakai S.

J Cardiol. 2019 Feb;73(2):163-170. doi: 10.1016/j.jjcc.2018.07.005. Epub 2018 Sep 3.

PMID: 30190094

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Select item 29706570

 

  1. Evaluation of ventricular septal defects using high pitch computed tomography angiography of the chest in children with complex congenital heart defects below one year of age.

Nau D, Wuest W, Rompel O, Hammon M, Gloeckler M, Toka O, Dittrich S, Rueffer A, Cesnjevar R, Lell MM, Uder M, May MS.

J Cardiovasc Comput Tomogr. 2019 Feb 1. pii: S1934-5925(18)30358-7. doi: 10.1016/j.jcct.2019.01.023. [Epub ahead of print]

PMID: 30737152

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Select item 30715377

Sildenafil Use in Children with Pulmonary Hypertension.

Cohen JL, Nees SN, Valencia GA, Rosenzweig EB, Krishnan US.

J Pediatr. 2019 Feb;205:29-34.e1. doi: 10.1016/j.jpeds.2018.09.067. Epub 2018 Nov 2.

PMID: 30396684

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Select item 30334928

 

  1. Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome.

MacFarlane EG, Parker SJ, Shin JY, Kang BE, Ziegler SG, Creamer TJ, Bagirzadeh R, Bedja D, Chen Y, Calderon JF, Weissler K, Frischmeyer-Guerrerio PA, Lindsay ME, Habashi JP, Dietz HC.

J Clin Invest. 2019 Feb 1;129(2):659-675. doi: 10.1172/JCI123547. Epub 2019 Jan 7. Infliximab, Is It Really a New Horizon for the Treatment of Kawasaki Disease?

Eun LY.

Korean Circ J. 2019 Feb;49(2):192-193. doi: 10.4070/kcj.2018.0460. No abstract available.

PMID: 30693682 Free PMC Article

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Select item 30711131

PMID: 30396684

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Select item 30334928

 

  1. Infliximab, Is It Really a New Horizon for the Treatment of Kawasaki Disease?

Eun LY.

Korean Circ J. 2019 Feb;49(2):192-193. doi: 10.4070/kcj.2018.0460. No abstract available.

PMID: 30693682 Free PMC Article

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Select item 30711131

 

  1. Reply to ‘Double-outlet right ventricle is not hypoplastic left heart syndrome’.

Lo CW, Liu X, Gabriel GC, Martin LJ, Porter GA, Benson DW.

Nat Genet. 2019 Feb;51(2):198-199. doi: 10.1038/s41588-018-0323-5. No abstract available.

PMID: 30617253

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Select item 29885419

 

  1. The Role of Computed Tomography Coronary Angiography in Kawasaki Disease: Comparison with Transthoracic Echocardiography in a 25-Case Retrospective Study.

Jrad M, Ben Salem F, Barhoumi C, Lassoued F, Frikha W, Boukriba S, Mizouni H.

Pediatr Cardiol. 2019 Feb;40(2):265-275. doi: 10.1007/s00246-018-2044-z. Epub 2019 Jan 2.

PMID: 30600370

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Select item 30600368

 

  1. Ventricular Arterial Coupling: A Novel Echocardiographic Risk Factor for Disease Progression in Pediatric Dilated Cardiomyopathy.

Capone CA, Lamour JM, Lorenzo J, Tria B, Ye K, Hsu DT, Mahgerefteh J.

Pediatr Cardiol. 2019 Feb;40(2):330-338. doi: 10.1007/s00246-018-2021-6. Epub 2018 Nov 10.

PMID: 30415380

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Select item 30415379

 

  1. Effect of Congenital Heart Disease Status on Trends in Pediatric Infective Endocarditis Hospitalizations in the United States Between 2000 and 2012.

Dolgner SJ, Arya B, Kronman MP, Chan T.

Pediatr Cardiol. 2019 Feb;40(2):319-329. doi: 10.1007/s00246-018-2020-7. Epub 2018 Nov 10.

PMID: 30415379

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  1. Comparison of Morphologic Findings in Patients with Dextrocardia with Situs Solitus vs Situs Inversus: a Retrospective Study.

Tripathi S, Ajit Kumar VK.

Pediatr Cardiol. 2019 Feb;40(2):302-309. doi: 10.1007/s00246-018-2007-4. Epub 2018 Oct 17.

PMID: 30334087

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Select item 30310940

 

  1. Coarctation of the aorta and left ventricular diverticulum in Kabuki syndrome.

Ko H, Kim G, Lee HD, Kim H, Sung SC.

Pediatr Int. 2019 Feb;61(2):200-201. doi: 10.1111/ped.13740. Epub 2019 Feb 11. No abstract available.

PMID: 30746822

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Select item 29776787

 

  1. Quantitative evaluation of fetal right and left ventricular fractional area change using speckle-tracking technology.

DeVore GR, Klas B, Satou G, Sklansky M.

Ultrasound Obstet Gynecol. 2019 Feb;53(2):219-228. doi: 10.1002/uog.19048.

PMID: 29536575

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  1. Vertical vein aneurysm in supracardiac total anomalous pulmonary venous connection.

Pandey NN, Sharma A, Kumar S.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):69-70. doi: 10.4103/apc.APC_100_18.

PMID: 30745776 Free PMC Article

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Select item 30745775

 

  1. Unroofed coronary sinus: An unusual interatrial communication and a rare childhood entity.

Murli L, Ranjit MS, Shah P.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):64-65. doi: 10.4103/apc.APC_119_18.

PMID: 30745774 Free PMC Article

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Select item 30745773

 

  1. Double whammy: A case of bilateral bicuspid arterial valves in transposition, with a review of the literature.

Shivaram P, Shah K, Dossey A, Reemtsen B, Anderson RH.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):56-59. doi: 10.4103/apc.APC_88_18.

PMID: 30745772 Free PMC Article

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Select item 30745771

 

  1. Symptomatic improvement using everolimus in infants with cardiac rhabdomyoma.

Dhulipudi B, Bhakru S, Rajan S, Doraiswamy V, Koneti NR.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):45-48. doi: 10.4103/apc.APC_79_18.

PMID: 30745769 Free PMC Article

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Select item 30745768

  1. N-terminal-pro-b-type natriuretic peptide levels and cardiac hemosiderosis in adolescent β-thalassemia major patients.

Kautsar A, Advani N, Andriastuti M.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):32-37. doi: 10.4103/apc.APC_49_18.

PMID: 30745767 Free PMC Article

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Select item 30745766

 

  1. Short-term clinical and echocardiographic outcomes after use of polytetrafluoroethylene bicuspid pulmonary valve during the repair of tetralogy of Fallot.

Wankhade PR, Aggarwal N, Joshi RK, Agarwal M, Joshi R, Mehta A, Kar S.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):25-31. doi: 10.4103/apc.APC_51_18.

PMID: 30745766 Free PMC Article

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Select item 30745765

 

  1. Neutrophil-to-lymphocyte ratio used as prognostic factor marker for dilated cardiomyopathy in childhood and adolescence.

Araújo FDDR, Silva RMFDL, Oliveira CAL, Meira ZMA.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):18-24. doi: 10.4103/apc.APC_47_18.

PMID: 30745765 Free PMC Article

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Select item 30745764

 

  1. Early predictors of cardiac dysfunction in Egyptian children with chronic kidney disease.

El-Gamasy MA, El-Shehaby WA, Mabrouk MM.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):10-17. doi: 10.4103/apc.APC_12_18.

PMID: 30745764 Free PMC Article

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Select item 30745763

 

  1. Early right ventricular function following trans-right atrial versus trans-right atrial, trans-right ventricular repair of Tetralogy of Fallot: Results of a prospective randomized study.

Talwar S, Anand A, Siddarth B, Ramakrishnan S, Choudhary SK, Airan B.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):3-9. doi: 10.4103/apc.APC_40_18.

PMID: 30745763 Free PMC Article

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Select item 30745762

 

 

 

 

 

ACHD Featured Articles in association with ISACHD

ACHD Featured Articles in association with ISACHD

Adult Congenital Heart Disease Featured Reviews of February 2019 Manuscripts (sponsored by ISACHD)

Sudden death in transposition of the great arteries with atrial switch surgery: Autopsy evidence of acute myocardial ischemia despite normal coronary arteries.

Chaix MA, Chergui M, Leduc C, Khairy P.

Int J Cardiol. 2019 Feb 14. pii: S0167-5273(18)36331-9. doi: 10.1016/j.ijcard.2019.02.026. [Epub ahead of print]

PMID: 30808604

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Select item 30765829

 

Take Home Points: 

  • Sudden cardiac death remains a leading cause for mortality in patients with transposition of the great arteries and an atrial switch.
  • This study provides evidence for a proposed mechanism: myocardial oxygen mismatch of the systemic RV when atrial rates are high, resulting in ischemia-driven ventricular arrhythmias and sudden cardiac death.

 

Commentary by Dr. Blanche Cupido (Cape Town), section editor of ACHD Journal Watch:  In patients with transposition of the great arteries and an atrial switch repair, sudden cardiac death is the main cause of mortality. The decision making for a primary prevention ICD remains difficult with little evidence to substantiate it. A proposed mechanism for sudden cardiac death in this group is thought to be myocardial oxygen supply mismatch of the systemic RV during high heart rates resulting in ischemia- related ventricular arrhythmias and death. This study provides histopathologic evidence in support of this theory.

This is a retrospective cohort study in Montreal, Canada of adults with transposition of the great arteries with an atrial switch procedure. Patients attending their clinic from 1989 onward were enrolled. Those patients with arterial switches or double outlet RV were excluded.

A total of 140 patients were analyzed. The average age was 37.6 years and 37.1% were female. A total of 8 patients (6% – 3 female, 5 male) had a cardiac arrest (of assumed arrhythmic cause) – three of these were successfully resuscitated. None had a prior history of coronary artery disease, ventricular arrhythmia or syncope.

Four patients had atrial arrhythmias, one had non-sustained VT on a Holter (asymptomatic) and two had pacemakers. Two thirds had at least moderate systemic RV dysfunction. Most patients (7 of 8) had NYHA I or II. For 5 patients, the circumstances around the time of arrest were documented: 3 events occurred on exertion, 1 at rest and 1 after methamphetamine use.

Of the 5 patients who died, 2 autopsies were performed. One patient died suddenly 7 days post -op (tricuspid valve replacement) and the other while walking to work (VT documented). Both had extensive acute necrosis of the hypertrophied systemic RV with normal coronary arteries and chronic subendocardial lesions.

These histopathological findings support the following theory: At rapid heart rates, stroke volume is impaired due to poor atrial contraction. This reduction in stroke volume together with the increased oxygen demand, decreased perfusion pressure and inefficient coronary circulation (systemic RV usually only has single coronary supply), induces ischemic ventricular arrhythmias.

 

Lifelong burden of small unrepaired atrial septal defect: Results from the Danish National Patient Registry.

Udholm S, Nyboe C, Karunanithi Z, Christensen AI, Redington A, Nielsen-Kudsk JE, Hjortdal VE.

Int J Cardiol. 2019 May 15;283:101-106. doi: 10.1016/j.ijcard.2019.02.024. Epub 2019 Feb 16.

PMID:  30826194

Similar articles

Take Home Points 

  • An analysis of survival and morbidity of all patients with a small unrepaired ASD listed in the Danish National Patient Registry (DNPR) between 1953 and 2011 compared to the background population.
  • 723 patients were defined as having a small unrepaired ASD in the DNPR.
  • Since the time of diagnosis 182 patients (25%) had died with a mean lifespan of 63 years. Mean age at diagnosis was late in these patients – 53 years.
  • The commonest cause of death was heart failure.
  • Compared to the general population, patients with an ‘insignificant’ unrepaired ASD had a higher burden of chronic disease (27% vs 38%, p=0.005) – particularly lung disease (1% vs 4%).
  • In a select number of patients aged 18-65 years, listed as having a small unrepaired ASD whom underwent TTE (n=153), the ASD had spontaneously closed in 80% (n=123).
  • 6MWT was significantly lower (632+/- 90m) in patients previous diagnosed with an ASD vs calculated reference values (715 +/- 94m, p=0.00001).
  • Further investigation and data collection is required to help explain why morbidity and mortality should be worse in patients with a seemingly ‘low risk’ congenital cardiac anomaly, even when the ASD closes spontaneously.

 

Commentary from Dr. Damien Cullington (Leeds UK), section editor of ACHD Journal Watch:  The Danish National Patient Registry (DNPR) is a remarkable epidemiological feat which has collated complete data on all residents living in Denmark since 1977. It contains information on all inpatient and outpatient hospital contacts in Denmark and diagnoses are made according to ICD definitions. Only patients with ASDs deemed to be ‘insignificant’ i.e. unrepaired, small, and with a Qp:Qs <1.5 were included in the analysis.

Between 2015 and 2018, patients remaining alive and aged 18-65 yrs. with an unrepaired ASD (n=361) were invited to undergo further testing – a questionnaire, TTE, spirometry and 6MWT – only 156 patients were included in this more extensive assessment (Fig 1) 

Patients with an ASD 

2277 adult patients were listed in the DNPR as having an ASD. Of these, just over two thirds of patients (n=1554) had surgical or device ASD closure. The remainder (n=723) had an unrepaired ASD. It is unclear how patients with seemingly small ASDs were diagnosed – often such patients are completely asymptomatic with few clinical signs on examination. It is inevitable that there are many more patients in the general population with small, ‘innocuous’ ASDs which are still undiscovered.

A quarter of patients with an unrepaired ASD (n=182) died at a mean age of death of 63 years (range 0.2-99.1 years). Of note, the mean age at diagnosis of those patients who died was relatively advanced at 53 +/-27 years old. Nearly half of deaths (n=47) were of cardiac aetiology. 

Figure 1. Flowchart of patient inclusion

 

 

Echo data (n=153) 

On TTE assessment, most ASDs had spontaneously closed and there were only 30 patients who had small, open ASDs. (Fig 2). Patients who still had a small ASD compared to those who had closed spontaneously, had larger right heart dimensions. No differences were seen in ventricular function, estimated filling pressures or estimated pulmonary pressures. The mean age at diagnosis of this patient cohort was 9 years old. 

Conclusions 

It is not clear from this analysis why patients with seemingly small, innocuous ASDs, even in those which have spontaneously closed have worse survival, more chronic disease, higher levels of anxiety and worse functional capacity. Continued observation and collection of epidemiological data is required. It is not clear if earlier closure of these small ASDs, often viewed as seemingly benign, can avert these adverse outcomes. Patients with even small ASDs should be followed up longer term to check for any clinical deterioration.

Figure 2. Echocardiographic data from selected patients listed in the DNPR as having an unrepaired ASD (n=153) who subsequently had echo. The ASD had spontaneously closed (n=123) vs remainder open (n=30).

 

 

Usefulness of Red Blood Cell Distribution Width in the Assessment of Hemodynamics After Tetralogy of Fallot Repair.

Kojima T, Imamura T, Osada Y, Muraji S, Nakano M, Oyanagi T, Yoshiba S, Kobayashi T, Sumitomo N.

Circ J. 2019 Feb 23. doi: 10.1253/circj.CJ-18-1016. [Epub ahead of print]

PMID: 30799372

 

Take Home Point: 

  • In this study of children undergoing routine hemodynamic assessment within a year of tetralogy of Fallot repair, higher RDW was predictive of suboptimal hemodynamics, including higher right ventricle pressure/left ventricle pressure ratio, elevated CVP, lower mixed venous oxygen saturation, increased pulmonary stenosis severity, increased pulmonary regurgitation severity by echo, and residual ventricular septal defect. Also, RDW was particularly associated with higher reoperation risk and the RDW tended to improve after reoperation.

Commentary by Dr. Maan Jokhadar (Atlanta), section editor of ACHD Journal Watch:  Red blood cell distribution  width (RDW) is routinely reported as part of a complete blood count and clinically useful for anemia evaluation. Elevated RDW is a sign of nutritional deficiency, including iron deficiency, vitamin B12 deficiency, etc. Also, there is a growing body of literature linking elevated RDW to worse outcomes with heart failure, coronary disease, pulmonary hypertension, and congenital heart disease, including Fontan patients.  The reasons for these associations are not clear but could be related to inflammatory stress, nutritional deficiency, and inadequate production of erythropoietin in the setting of  suboptimal hemodynamic state.

Dr. Kojima and colleagues in Saitana, Japan  performed a retrospective analysis of 50 children who were admitted for postoperative cardiac catheterization after surgical tetralogy of Fallot repair, which is part of routine postoperative management in this center. The mean age at the time of surgical repair was about 6.6 +/- 2.1 months (range 3 to 12 months) and cardiac catheterization was performed 11.3 +/- 9.6 months after surgery.   About 56% had transannular patch repair and about  24% had a previous palliative shunt. Ten patients had residual VSD. Seven patients had reoperation due to significant VSD in 4 patients and pulmonary stenosis in 3 patients.

In this pediatric population undergoing routine hemodynamic assessment after recent tetralogy of Fallot repair, higher RDW was associated with higher right ventricle pressure/left ventricle pressure ratio, elevated CVP, lower mixed venous oxygen saturation, increased pulmonary stenosis severity, increased pulmonary regurgitation severity by echo, and residual ventricular septal defect. Also, RDW was particularly associated with higher reoperation risk and the RDW tended to improve after reoperation. Thus, RDW was associated with both right ventricle volume overload and pressure overload.  In addition, RDW appeared to be more predictive than BNP in this population.

 

These data are an important step forward and bolster the argument that  RDW may have value as part of the hemodynamic and prognosis assessment in patients with repaired tetralogy of Fallot. However, larger prospective studies are needed to better understand the role of RDW in this realm.

 

Differences in Cardiovascular Manifestation of Marfan Syndrome Between Children and Adults.

Wozniak-Mielczarek L, Sabiniewicz R, Drezek-Nojowicz M, Nowak R, Gilis-Malinowska N, Mielczarek M, Łabuc A, Waldoch A, Wierzba J.

Pediatr Cardiol. 2019 Feb;40(2):393-403. doi: 10.1007/s00246-018-2025-2. Epub 2018 Nov 11.

PMID: 30417312

Similar articles

Select item 30415381 

Take Home Points: 

  • Aortic root and ascending aorta dilatation, mitral valve prolapse and aortic regurgitation are equally prevalent in children and adults, while aortic arch, descending aorta and pulmonary truck dilatation are more common in adults.
  • Aortic root dilatation is the primary cardiovascular manifestation of Marfan syndrome (81%), equally prevalent in adults and children with no predilection for male or female sex.
  • Dilatation of the sinotubular junction (33%) and distal ascending aorta (27%) occurs in similar frequency amongst adults and children, and always in association with aortic root dilatation.
  • Aortic arch (9 %) and descending thoracic or abdominal aorta (11%) dilatation is more common in adult patients than children.
  • Aortic dissection was retrospectively noted in 8 patients (8%) at a mean age of 26 +/- 7 years; 3 of 4 females (75 %) were affected during the third trimester of pregnancy.
  • Aortic valve regurgitation present in 26 patients (31%) but only mild in the majority (92%) .
  • Mitral valve prolapse is common in adults and children (53 and 57%, respectively).
  • Pulmonary trunk dilatation is more frequent in adults as compared to children (37 vs. 16%, P=0.025). 

Commentary from Dr. Timothy Roberts (Melbourne), section editor of ACHD Journal Watch:  This observational study aimed to assess differences in the frequency of cardiovascular manifestations of Marfan syndrome in a series of 236 patients referred for assessment of suspected Marfan syndrome. Referral indications included body stature (27 %), family history of Marfan syndrome (24 %), joint hypermobility (14 %), chest deformity (7 %), scoliosis (6 %), aortic dilatation or dissection (5 %) and lens dislocation (5 %). Marfan syndrome was diagnosed in 101 patients (43 %: 44/144 children, 57/92 adults) according to the modified Ghent criteria. The mean age at diagnosis of Marfan syndrome was 24 +/- 15 years (2 months – 65 years) with 46 % female gender. A family history of Marfan syndrome was present in 68 %. Genetic testing was not performed to confirm a clinical diagnosis of Marfan syndrome. Cardiovascular testing involved electrocardiography, 24-hour ambulatory monitoring and transthoracic echocardiography.

Aortic root dilatation was present in 81 % of Marfan subjects, affecting adults (49/57, 86 %) and children (33/44, 75 %) to a similar extent. A modest correlation was demonstrated between aortic root diameter and patient age (R=0.335, p=0.008). Subjects were further sub-grouped into four age categories (2 months – 9 years, 10 – 17 years, 18 – 29 years, and 30 – 65 years) with the highest z-score observed in adults (4.69 in 18 – 29 year group, 4.25 in the 30 – 65 year group; P=0.429). There was no difference in degree of aortic root dilatation according to sex.

Aortic arch dilatation occurred in 9 patients (9 %), more frequently in adults than children (P=0.04). Similarly, adults had a greater prevalence of descending thoracic or abdominal aorta dilatation (18 vs. 2 %, p=0.015).

Aortic dissection (retrospectively) occurred in 8 subjects: 6 adults (11 %) and 2 children (5 %). Type A dissection contributed to 5 of these events. Of note, 3 of the four females with dissection were affected during the third trimester of pregnancy.

Aortic regurgitation was diagnosed in 26 patients (31 %), being only mild in the majority and moderate in two adults (8 %). Prevalence was not different in adults and children. Four subjects had bicuspid aortic valve morphology.

Mitral regurgitation of any aetiology and severity was more common in adults than children (77 vs. 45 %, P=0.002), however the prevalence of mitral valve prolapse was similar (54 %) and severe mitral regurgitation was demonstrated in < 10 % of subjects overall.

Ambulatory 24-hour monitoring identified frequent (> 1000/day) ventricular (9 %) and supraventricular extrasystoles (5 %) without a statistically significant difference between adult and child subjects.

The data presented in the current study is informative while limited by the lack of longitudinal data. Nonetheless, similar to other studies it identifies high rates of aortic root dilatation and mitral valve prolapse, both of which are equally prevalent amongst children and adults. A further important point to highlight is the risk of aortic dissection during pregnancy. Although the affected women in this study were not formerly diagnosed with Marfan syndrome at the time of dissection, we must never forget the importance of pre-pregnancy counselling and to have a low threshold for aortic root surgery in our female Marfan syndrome patients of child-bearing age.

 

Ventilatory and sensory responses to incremental exercise in adults with a Fontan circulation.

Guenette JA, Ramsook AH, Dhillon SS, Puyat JH, Riahi M, Opotowsky AR, Grewal J.

Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H335-H344. doi: 10.1152/ajpheart.00322.2018. Epub 2018 Nov 2.

PMID:  30388023

Similar articles 

Take Home Points: 

Compared to controls, patients with Fontan circulation have:

  • restrictive ventilatory impairment,
  • higher ventilatory requirement for the same amount of work rate, and
  • higher sensory response to exercise (breathing and legs discomfort) at a given work rate. 

Commentary from Dr. M.C. Leong (Kuala Lumpur), section editor of ACHD Journal Watch:  The reduced exercise capacity in patients with Fontan circulation is largely thought to be driven by the inability of the heart to increase preload to match the increase of cardiac output. Though not systemically studied before, pulmonary function abnormalities during exercise may also be a contributing factor to reduced exercise capacity. This study aimed to describe the ventilatory and sensory response during exercise in adults with Fontan circulation.

This is a case control study involving 17 patients with Fontan circulation and 17 matched controls. The authors found that patients with Fontan had lower values for most pulmonary function measurements (Table 3). They had a lower total lung capacity but at the same time, a normal FEV1/FVC ratio, suggesting an inherent restrictive ventilatory defect. They also had significantly higher breathing frequency, end-inspiratory lung volume, ventilator inefficiency (high VE/VCO2) and dyspnea.  In terms of sensory response, patients with Fontan achieved a breathing discomfort and legs discomfort scores similar to controls at a much lower work rate (Figure 5). There was no difference in the qualitative descriptors of dyspnea and the dyspnea intensity rating.

The authors noted that patients in the Fontan group had other confounding factors such as poorer ventricular function, atrio-ventricular valve regurgitation and beta-blocker use which may affect exercise capacity and the sensory response of these patients.

ACHD Feb 2019

 

  1. Substantial Cardiovascular Morbidity in Adults with Lower-Complexity Congenital Heart Disease.

Saha P, Potiny P, Rigdon J, Morello M, Tcheandjieu C, Romfh A, Fernandes SM, McElhinney DB, Bernstein D, Lui GK, Shaw GM, Ingelsson E, Priest JR.

Circulation. 2019 Feb 28. doi: 10.1161/CIRCULATIONAHA.118.037064. [Epub ahead of print]

PMID: 30813762

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Select item 30819207

 

  1. Copy number variation analysis in bicuspid aortic valve-related aortopathy identifies TBX20 as a contributing gene.

Luyckx I, Kumar AA, Reyniers E, Dekeyser E, Vanderstraeten K, Vandeweyer G, Wünnemann F, Preuss C, Mazzella JM, Goudot G, Messas E, Albuisson J, Jeunemaitre X, Eriksson P, Mohamed SA, Kempers M, Salemink S, Duijnhouwer A, Andelfinger G, Dietz HC, Verstraeten A, Van Laer L, Loeys BL; MIBAVA Leducq Consortium.

Eur J Hum Genet. 2019 Feb 28. doi: 10.1038/s41431-019-0364-y. [Epub ahead of print]

PMID: 30820038

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Select item 30578391

 

  1. ERS statement on exercise training and rehabilitation in patients with severe chronic pulmonary hypertension.

Grünig E, Eichstaedt C, Barberà JA, Benjamin N, Blanco I, Bossone E, Cittadini A, Coghlan G, Corris P, D’Alto M, D’Andrea A, Delcroix M, de Man F, Gaine S, Ghio S, Gibbs S, Gumbiene L, Howard LS, Johnson M, Jurevičienė E, Kiely DG, Kovacs G, MacKenzie A, Marra AM, McCaffrey N, McCaughey P, Naeije R, Olschewski H, Pepke-Zaba J, Reis A, Santos M, Saxer S, Tulloh RM, Ulrich S, Vonk Noordegraaf A, Peacock AJ.

Eur Respir J. 2019 Feb 28;53(2). pii: 1800332. doi: 10.1183/13993003.00332-2018. Print 2019 Feb.

PMID: 30578391

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Select item 30819232

 

  1. Maternal and fetal outcomes in pregnancies complicated by the inherited aortopathy Loeys Dietz Syndrome.

Cauldwell M, Steer PJ, Curtis S, Mohan AR, Dockree S, Mackillop L, Parry H, Oliver J, Sterrenburg M, Bolger A, Siddiqui F, Simpson M, Walker N, Bredaki F, Walker F, Johnson MR.

BJOG. 2019 Feb 27. doi: 10.1111/1471-0528.15670. [Epub ahead of print]

PMID: 30811810

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Select item 30811836

 

  1. Intensive recreational athletes in the prospective multinational ICD Sports Safety Registry: Results from the European cohort.

Heidbuchel H, Willems R, Jordaens L, Olshansky B, Carre F, Lozano IF, Wilhelm M, Müssigbrodt A, Huybrechts W, Morgan J, Anfinsen OG, Prior D, Mont L, Mairesse GH, Boveda S, Duru F, Kautzner J, Viskin S, Geelen P, Cygankiewicz I, Hoffmann E, Vandenberghe K, Cannom D, Lampert R.

Eur J Prev Cardiol. 2019 Feb 27:2047487319834852. doi: 10.1177/2047487319834852. [Epub ahead of print]

PMID: 30813818

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Select item 30826226

 

  1. Patient-reported outcomes of adults with congenital heart disease from eight European countries: scrutinising the association with healthcare system performance.

Van Bulck L, Luyckx K, Goossens E, Apers S, Kovacs AH, Thomet C, Budts W, Sluman MA, Eriksen K, Dellborg M, Berghammer M, Johansson B, Caruana M, Soufi A, Callus E, Moons P.

Eur J Cardiovasc Nurs. 2019 Feb 26:1474515119834484. doi: 10.1177/1474515119834484. [Epub ahead of print]

PMID: 30808198

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Select item 30806948

 

  1. Reconstruction of anomalous left coronary artery from pulmonary artery in an adult patient: a case report.

Mori K, Anai H, Wada T, Shuto T, Miyamoto S.

J Cardiothorac Surg. 2019 Feb 26;14(1):40. doi: 10.1186/s13019-019-0866-2.

PMID: 30808374 Free Article

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Select item 30806154

 

  1. Atrial Septal Defect of the Ostium Secundum Type in A 101-Year-Old Patient.

Matsumoto T, Tamiya E, Kanoh T, Takabe T, Kuremoto KI, Kamiyama T, Yamamoto S, Daida H.

Int Heart J. 2019 Feb 22. doi: 10.1536/ihj.18-354. [Epub ahead of print]

PMID: 30799379 Free Article

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Select item 30794526

 

  1. Prosthetic pulmonary valve and conduit endocarditis in congenital heart disease.

Rebollal-Leal F, Felipe-Abella R, Gutierrez-García F, A Mestres C, Bautista-Hernandez V.

Asian Cardiovasc Thorac Ann. 2019 Feb 21:218492319832769. doi: 10.1177/0218492319832769. [Epub ahead of print]

PMID: 30791694

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Select item 30790426

 

  1. The genetic basis of Turner syndrome aortopathy.

Corbitt H, Gutierrez J, Silberbach M, Maslen CL.

Am J Med Genet C Semin Med Genet. 2019 Feb 16. doi: 10.1002/ajmg.c.31686. [Epub ahead of print]

PMID: 30770620

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Select item 30772822

 

  1. Lifelong burden of small unrepaired atrial septal defect: Results from the Danish National Patient Registry.

Udholm S, Nyboe C, Karunanithi Z, Christensen AI, Redington A, Nielsen-Kudsk JE, Hjortdal VE.

Int J Cardiol. 2019 Feb 16. pii: S0167-5273(18)37022-0. doi: 10.1016/j.ijcard.2019.02.024. [Epub ahead of print]

PMID: 30826194

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Select item 30803889

 

  1. Pulmonary arterial hypertension in adults with systemic right ventricles referred for cardiac transplantation.

Kim YY, Awh K, Acker M, Atluri P, Bermudez C, Crespo M, Diamond JM, Drajpuch D, Forde-Mclean R, Fuller S, Goldberg L, Mazurek J, Mascio C, Menachem JN, Rame E, Ruckdeschel E, Tobin L, Wald J.

Clin Transplant. 2019 Feb 15:e13496. doi: 10.1111/ctr.13496. [Epub ahead of print]

PMID: 30770573

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Select item 30767157

 

  1. Where are we with coronary artery disease for the cyanotic patient with congenital heart disease?

Segura T, Gatzoulis MA.

Int J Cardiol. 2019 Feb 15;277:108-109. doi: 10.1016/j.ijcard.2018.10.033. Epub 2018 Oct 12. No abstract available.

PMID: 30665555

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Select item 30482629

 

  1. Predicting acquired cardiovascular disease in adults with congenital heart disease is risky business.

Lui GK, Bhatt AB.

Int J Cardiol. 2019 Feb 15;277:106-107. doi: 10.1016/j.ijcard.2018.10.061. Epub 2018 Oct 22. No abstract available.

PMID: 30482629

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Select item 30262228

 

  1. Age-related cardiovascular risk in adult patients with congenital heart disease.

Häcker AL, Oberhoffer R, Hager A, Ewert P, Müller J.

Int J Cardiol. 2019 Feb 15;277:90-96. doi: 10.1016/j.ijcard.2018.09.042. Epub 2018 Sep 12.

PMID: 30262228

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Select item 30228018

 

  1. Subclinical atherosclerosis in patients with cyanotic congenital heart disease.

Tarp JB, Sørgaard MH, Christoffersen C, Jensen AS, Sillesen H, Celermajer D, Eriksson P, Estensen ME, Nagy E, Holstein-Rathlou NH, Engstrøm T, Søndergaard L.

Int J Cardiol. 2019 Feb 15;277:97-103. doi: 10.1016/j.ijcard.2018.08.104. Epub 2018 Sep 3.

PMID: 30228018

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Select item 30195839

 

  1. Contemporary ACHD training and the reality of the field in the United States.

Ephrem G, Alshawabkeh L.

Int J Cardiol. 2019 Feb 15;277:85-89. doi: 10.1016/j.ijcard.2018.08.086. Epub 2018 Sep 1.

PMID: 30195839

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Select item 30177234

 

  1. Pulmonary artery dilatation in congenital heart disease: Size doesn’t matter.

Greutmann M.

Int J Cardiol. 2019 Feb 15;277:235-236. doi: 10.1016/j.ijcard.2018.08.063. Epub 2018 Aug 23. No abstract available.

PMID: 30177234

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Select item 30100225

 

  1. Cardiovascular risk factors in adults with congenital heart defects – Recognised but not treated? An analysis of the German National Register for Congenital Heart Defects.

Bauer UMM, Körten MA, Diller GP, Helm P, Baumgartner H, Ewert P, Tutarel O.

Int J Cardiol. 2019 Feb 15;277:79-84. doi: 10.1016/j.ijcard.2018.08.009. Epub 2018 Aug 4.

PMID: 30100225

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Select item 30801451

 

  1. Imaging Spectrum of Double-Outlet Right Ventricle on Multislice Computed Tomography.

Priya S, Nagpal P, Sharma A, Pandey NN, Jagia P.

J Thorac Imaging. 2019 Feb 15. doi: 10.1097/RTI.0000000000000396. [Epub ahead of print]

PMID: 30801451

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Select item 30639391

 

  1. EXPRESS: High-risk pregnancy in a patient with pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) with temporary shunt inversion and deoxygenation.

Hohmann C, Dumitrescu D, Gerhardt F, Kramer T, Rosenkranz S, Huntgeburth M.

Pulm Circ. 2019 Feb 15:2045894019835649. doi: 10.1177/2045894019835649. [Epub ahead of print] No abstract available.

PMID: 30767601

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Select item 30800301

 

  1. Sudden death in transposition of the great arteries with atrial switch surgery: Autopsy evidence of acute myocardial ischemia despite normal coronary arteries.

Chaix MA, Chergui M, Leduc C, Khairy P.

Int J Cardiol. 2019 Feb 14. pii: S0167-5273(18)36331-9. doi: 10.1016/j.ijcard.2019.02.026. [Epub ahead of print]

PMID: 30808604

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Select item 30765829

 

  1. Heart beat but not respiration is the main driving force of the systemic venous return in the Fontan circulation.

Gabbert DD, Hart C, Jerosch-Herold M, Wegner P, Ravesh MS, Voges I, Kristo I, Bulushi AAL, Scheewe J, Kheradvar A, Kramer HH, Rickers C.

Sci Rep. 2019 Feb 14;9(1):2034. doi: 10.1038/s41598-019-38848-5.

PMID: 30765829 Free PMC Article

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Select item 30758225

 

  1. Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence.

van der Feen DE, Berger RMF, Bartelds B.

Am J Respir Cell Mol Biol. 2019 Feb 13. doi: 10.1165/rcmb.2018-0329TR. [Epub ahead of print]

PMID: 30758225

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Select item 30760879

 

  1. Adults with congenital heart disease: ready for mobile health?

Treskes RW, Koole M, Kauw D, Winter MM, Monteiro M, Dohmen D, Abu-Hanna A, Schijven MP, Mulder BJ, Bouma BJ, Schuuring MJ.

Neth Heart J. 2019 Feb 13. doi: 10.1007/s12471-019-1237-2. [Epub ahead of print]

PMID: 30758718

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Select item 30758099

 

  1. Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study.

Padalino MA, Franchetti N, Sarris GE, Hazekamp M, Carrel T, Frigiola A, Horer J, Roussin R, Cleuziou J, Meyns B, Fragata J, Telles H, Polimenakos AC, Francois K, Veshti A, Salminen J, Rocafort AG, Nosal M, Vedovelli L, Protopapas E, Tumbarello R, Merola A, Pegoraro C, Motta R, Boccuzzo G, Sojak V, Rito ML, Caldaroni F, Corrado D, Basso C, Stellin G.

Int J Cardiol. 2019 Feb 10. pii: S0167-5273(18)37161-4. doi: 10.1016/j.ijcard.2019.02.007. [Epub ahead of print]

PMID: 30772012 Free Article

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Select item 30740804

 

  1. High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study.

Talarowska P, Dobrowolski P, Klisiewicz A, Kostera-Pruszczyk A, Członkowska A, Kurkowska-Jastrzębska I, Gąsecki D, Warchoł-Celińska E, Światłowski Ł, Florczak E, Januszewicz M, Michałowska I, Józwik-Plebanek K, Szczudlik P, Błażejewska-Hyżorek B, Protasiewicz M, Odrowąż-Pieniążek P, Tekieli Ł, Michel-Rowicka K, Hanus K, Widecka K, Sołtysiak M, Tykarski A, Stryczyński Ł, Szczerbo-Trojanowska M, Hoffman P, Prejbisz A, Januszewicz A.

Vasc Med. 2019 Feb 10:1358863X18811596. doi: 10.1177/1358863X18811596. [Epub ahead of print]

PMID: 30739593

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Select item 30744090

 

  1. A case of unguarded tricuspid valve orifice diagnosed accidentally in an adult.

Abdelnabi MH, Shehata H, Saleh Y, Elgowelly M, Almaghraby A.

Echocardiography. 2019 Feb 9. doi: 10.1111/echo.14273. [Epub ahead of print]

PMID: 30738004

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Select item 30735477

 

  1. Coexistence an aberrant right subclavian artery with other congenital anomalies: case report and review of the literature.

Mrochek AG, Kabak SL, Haidzel IK, Melnichenko YM, Kalenchic TI.

Surg Radiol Anat. 2019 Feb 8. doi: 10.1007/s00276-019-02206-x. [Epub ahead of print]

PMID: 30737539

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Select item 30735591

 

  1. Endocarditis following IUD insertion in a patient with tetralogy of Fallot.

Meyerowitz EA, Prager S, Stout K, Roxby A.

BMJ Case Rep. 2019 Feb 7;12(2). pii: bcr-2018-227962. doi: 10.1136/bcr-2018-227962.

PMID: 30737328

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Select item 30753373

 

  1. Using psychologically informed care to improve mental health and wellbeing for people living with a heart condition from birth: A statement paper.

Morton L.

J Health Psychol. 2019 Feb 7:1359105319826354. doi: 10.1177/1359105319826354. [Epub ahead of print]

PMID: 30729809

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Select item 30741756

 

  1. Computed Tomography Appearance of Uncorrected Congenital Heart Disease in Adults.

Maldjian PD, Yen LH.

J Thorac Imaging. 2019 Feb 7. doi: 10.1097/RTI.0000000000000397. [Epub ahead of print]

PMID: 30741756

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Select item 30732632

 

  1. Accuracy of risk prediction scores in pregnant women with congenital heart disease.

Kim YY, Goldberg LA, Awh K, Bhamare T, Drajpuch D, Hirshberg A, Partington SL, Rogers R, Ruckdeschel E, Tobin L, Venuti M, Levine LD.

Congenit Heart Dis. 2019 Feb 6. doi: 10.1111/chd.12750. [Epub ahead of print]

PMID: 30729681

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Select item 30726509

 

  1. Non-invasive Hemodynamic CMR Parameters Predicting Maximal Exercise Capacity in 54 Patients with Ebstein’s Anomaly.

Meierhofer C, Kühn A, Müller J, Shehu N, Hager A, Martinoff S, Stern H, Ewert P, Vogt M.

Pediatr Cardiol. 2019 Feb 6. doi: 10.1007/s00246-019-02066-7. [Epub ahead of print]

PMID: 30726509

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  1. Diagnostic Work-Up of Pulmonary Hypertension – Think About Shunt Flow! A Case Report.

Hinrichs L, Horacek M, Neudorf U, Schlosser T, Rassaf T, Totzeck M.

Am J Case Rep. 2019 Feb 5;20:154-158. doi: 10.12659/AJCR.912191.

PMID: 30718448 Free PMC Article

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Select item 30722675

 

  1. Use of Medication for Cardiovascular Disease During Pregnancy: JACC State-of-the-Art Review.

Halpern DG, Weinberg CR, Pinnelas R, Mehta-Lee S, Economy KE, Valente AM.

J Am Coll Cardiol. 2019 Feb 5;73(4):457-476. doi: 10.1016/j.jacc.2018.10.075. Review.

PMID: 30704579

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Select item 30722102

 

  1. DAN plays important compensatory roles in systemic-to-pulmonary shunt associated pulmonary arterial hypertension.

Meng L, Liu X, Teng X, Yuan W, Duan L, Meng J, Li J, Zheng Z, Wei Y, Hu S.

Acta Physiol (Oxf). 2019 Feb 4:e13263. doi: 10.1111/apha.13263. [Epub ahead of print]

PMID: 30715799

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Select item 30714565

 

  1. Strategy of treating secundum atrial septal defect not referred to percutaneous closure.

Zhang F, Yang Y, Wu Q, Jin W, Bu H, Wu S, Zhao T, Hu S.

Congenit Heart Dis. 2019 Feb 4. doi: 10.1111/chd.12753. [Epub ahead of print]

PMID: 30714327

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Select item 30714326

 

  1. Education as important predictor for successful employment in adults with congenital heart disease worldwide.

Sluman MA, Apers S, Sluiter JK, Nieuwenhuijsen K, Moons P, Luyckx K, Kovacs AH, Thomet C, Budts W, Enomoto J, Yang HL, Jackson JL, Khairy P, Cook SC, Subramanyan R, Alday L, Eriksen K, Dellborg M, Berghammer M, Mattsson E, Mackie AS, Menahem S, Caruana M, Gosney K, Soufi A, Fernandes SM, White KS, Callus E, Kutty S, Bouma BJ, Mulder BJM; APPROACH-IS consortium, the International Society for Adult Congenital Heart Disease (ISACHD).

Congenit Heart Dis. 2019 Feb 4. doi: 10.1111/chd.12747. [Epub ahead of print]

PMID: 30714326

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Select item 30717604

 

  1. Pregnancy still contraindicated in pulmonary arterial hypertension related to congenital heart disease: True or false?

Ntiloudi D, Giannakoulas G.

Eur J Prev Cardiol. 2019 Feb 4:2047487318825347. doi: 10.1177/2047487318825347. [Epub ahead of print] No abstract available.

PMID: 30717604

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Select item 30714251

 

  1. Estimation of Cardiovascular Relative Pressure Using Virtual Work-Energy.

Marlevi D, Ruijsink B, Balmus M, Dillon-Murphy D, Fovargue D, Pushparajah K, Bertoglio C, Colarieti-Tosti M, Larsson M, Lamata P, Figueroa CA, Razavi R, Nordsletten DA.

Sci Rep. 2019 Feb 4;9(1):1375. doi: 10.1038/s41598-018-37714-0.

PMID: 30718699 Free PMC Article

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Select item 30731194

 

  1. Cardiac auscultation: normal and abnormal.

Warriner D, Michaels J, Morris PD.

Br J Hosp Med (Lond). 2019 Feb 2;80(2):C28-C31. doi: 10.12968/hmed.2019.80.2.C28. No abstract available.

PMID: 30747003

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Select item 30820050

 

  1. Ventilatory and sensory responses to incremental exercise in adults with a Fontan circulation.

Guenette JA, Ramsook AH, Dhillon SS, Puyat JH, Riahi M, Opotowsky AR, Grewal J.

Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H335-H344. doi: 10.1152/ajpheart.00322.2018. Epub 2018 Nov 2.

PMID: 30388023

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Select item 29706438

 

  1. Functional outcome in contemporary children and young adults with tetralogy of Fallot after repair.

Hock J, Häcker AL, Reiner B, Oberhoffer R, Hager A, Ewert P, Müller J.

Arch Dis Child. 2019 Feb;104(2):129-133. doi: 10.1136/archdischild-2017-314733. Epub 2018 Jul 3.

PMID: 29970581

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Select item 29599167

 

  1. Quality of life in young people with congenital heart disease is better than expected.

Reiner B, Oberhoffer R, Ewert P, Müller J.

Arch Dis Child. 2019 Feb;104(2):124-128. doi: 10.1136/archdischild-2017-314211. Epub 2018 Mar 29.

PMID: 29599167

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Select item 29748228

 

  1. Prevalence of smoking and clinical characteristics in fibromuscular dysplasia. The ARCADIA-POL study.

Dobrowolski P, Januszewicz M, Witowicz H, Warchoł-Celińska E, Klisiewicz A, Skrzypczyńska-Banasik U, Kabat M, Kowalczyk K, Aniszczuk-Hybiak A, Florczak E, Witkowski A, Tykarski A, Widecka K, Szczerbo-Trojanowska M, Śmigielski W, Drygas W, Michałowska I, Hoffman P, Prejbisz A, Januszewicz A.

Blood Press. 2019 Feb;28(1):49-56. doi: 10.1080/08037051.2018.1514252. Epub 2018 Dec 18.

PMID: 30560699

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Select item 30412445

 

  1. Psychological distress in adults with congenital heart disease: focus beyond depression.

Gleason LP, Deng LX, Khan AM, Drajpuch D, Fuller S, Ludmir J, Mascio CE, Partington SL, Tobin L, Kim YY, Kovacs AH.

Cardiol Young. 2019 Feb;29(2):185-189. doi: 10.1017/S1047951118002068. Epub 2019 Jan 30.

PMID: 30698116

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Select item 30351525

 

  1. Velocity vector imaging for the assessment of segmental ventricular function in children with a single right ventricle after cavopulmonary anastomosis.

Chen LJ, Zhang YQ, Bao SF, Zhong SW, Sun AM, Zhang ZF.

Curr Med Res Opin. 2019 Feb;35(2):203-210. doi: 10.1080/03007995.2018.1460337. Epub 2018 May 10.

PMID: 29611724

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Select item 30711722

 

  1. The Year in Cardiology 2018: Valvular Heart Disease.

Wojakowski W, Baumgartner H.

Eur Heart J. 2019 Feb 1;40(5):414-421. doi: 10.1093/eurheartj/ehy893. No abstract available.

PMID: 30602001

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Select item 30198757

 

  1. Development and effects of a self-management efficacy promotion program for adult patients with congenital heart disease.

Lee MJ, Jung D.

Eur J Cardiovasc Nurs. 2019 Feb;18(2):140-148. doi: 10.1177/1474515118800099. Epub 2018 Sep 10.

PMID: 30198757

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Select item 30520544

 

  1. Prognostic value of multiple repeated biomarkers in pulmonary arterial hypertension associated with congenital heart disease.

van Dissel AC, Blok IM, Zwinderman AH, van Dijk APJ, Duijnhouwer AL, de Winter RJ, Mulder BJM, Bouma BJ.

Eur J Heart Fail. 2019 Feb;21(2):249-251. doi: 10.1002/ejhf.1363. Epub 2018 Dec 6. No abstract available.

PMID: 30520544

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Select item 30381865

 

  1. Psychological interventions for people affected by childhood-onset heart disease: A systematic review.

Tesson S, Butow PN, Sholler GF, Sharpe L, Kovacs AH, Kasparian NA.

Health Psychol. 2019 Feb;38(2):151-161. doi: 10.1037/hea0000704.

PMID: 30652913

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Select item 30329053

 

  1. Risk stratification in congenital heart disease – A call for protocolised assessment and multicentre collaboration.

Kempny A, Fraisse A, Dimopoulos K.

Int J Cardiol. 2019 Feb 1;276:114-115. doi: 10.1016/j.ijcard.2018.11.101. Epub 2018 Nov 20. No abstract available.

PMID: 30503190

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Select item 30503188

 

54.. Computational modelling in congenital heart disease: Challenges and opportunities.

Gallo D, Montanaro C, Morbiducci U.

Int J Cardiol. 2019 Feb 1;276:116-117. doi: 10.1016/j.ijcard.2018.11.109. Epub 2018 Nov 22. No abstract available.

PMID: 30503188

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Select item 30477928

 

  1. Psychosocial sphere of congenital heart disease patients and the costs of forgetting about it.

Meras P, Barradas-Pires A, Gatzoulis M.

Int J Cardiol. 2019 Feb 1;276:112-113. doi: 10.1016/j.ijcard.2018.10.054. Epub 2018 Oct 17. No abstract available.

PMID: 30413301

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Select item 30224258

 

  1. Depression and anxiety are associated with high health care utilization and mortality among adults with congenital heart disease.

Benderly M, Kalter-Leibovici O, Weitzman D, Blieden L, Buber J, Dadashev A, Mazor-Dray E, Lorber A, Nir A, Yalonetsky S, Razon Y, Chodick G, Hirsch R; Israeli Congenital Heart Disease Research Group.

Int J Cardiol. 2019 Feb 1;276:81-86. doi: 10.1016/j.ijcard.2018.09.005. Epub 2018 Sep 12.

PMID: 30224258

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Select item 30201381

 

  1. Mode of death and predictors of mortality in adult Fontan survivors: A Japanese multicenter observational study.

Ohuchi H, Inai K, Nakamura M, Park IS, Watanabe M, Hiroshi O, Kim KS, Sakazaki H, Waki K, Yamagishi H, Yamamura K, Kuraishi K, Miura M, Nakai M, Nishimura K, Niwa K; JSACHD Fontan Investigators.

Int J Cardiol. 2019 Feb 1;276:74-80. doi: 10.1016/j.ijcard.2018.09.002. Epub 2018 Sep 5.

PMID: 30201381

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Select item 30172474

 

  1. Development and validation of a risk prediction model in patients with adult congenital heart disease.

Baggen VJM, Venema E, Živná R, van den Bosch AE, Eindhoven JA, Witsenburg M, Cuypers JAAE, Boersma E, Lingsma H, Popelová JR, Roos-Hesselink JW.

Int J Cardiol. 2019 Feb 1;276:87-92. doi: 10.1016/j.ijcard.2018.08.059. Epub 2018 Aug 22.

PMID: 30172474

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Select item 30535467

 

  1. Parental uncertainty about transferring their adolescent with congenital heart disease to adult care.

Burström Å, Acuna Mora M, Öjmyr-Joelsson M, Sparud-Lundin C, Rydberg A, Hanseus K, Frenckner B, Nisell M, Moons P, Bratt EL.

J Adv Nurs. 2019 Feb;75(2):380-387. doi: 10.1111/jan.13852. Epub 2018 Oct 18.

PMID: 30209810

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Select item 30579694

 

  1. Guidelines for Performing a Comprehensive Transesophageal Echocardiographic: Examination in Children and All Patients with Congenital Heart Disease: Recommendations from the American Society of Echocardiography.

Puchalski MD, Lui GK, Miller-Hance WC, Brook MM, Young LT, Bhat A, Roberson DA, Mercer-Rosa L, Miller OI, Parra DA, Burch T, Carron HD, Wong PC.

J Am Soc Echocardiogr. 2019 Feb;32(2):173-215. doi: 10.1016/j.echo.2018.08.016. Epub 2018 Dec 25. No abstract available.

PMID: 30579694

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Select item 30525196

 

  1. Caval to pulmonary 3D flow distribution in patients with Fontan circulation and impact of potential 4D flow MRI error sources.

Jarvis K, Schnell S, Barker AJ, Rose M, Robinson JD, Rigsby CK, Markl M.

Magn Reson Med. 2019 Feb;81(2):1205-1218. doi: 10.1002/mrm.27455. Epub 2018 Sep 15.

PMID: 30277276

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Select item 30194880

 

  1. Real-time cardiovascular MR with spatio-temporal artifact suppression using deep learning-proof of concept in congenital heart disease.

Hauptmann A, Arridge S, Lucka F, Muthurangu V, Steeden JA.

Magn Reson Med. 2019 Feb;81(2):1143-1156. doi: 10.1002/mrm.27480. Epub 2018 Sep 8.

PMID: 30194880

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63, Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease.

Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW.

Mol Metab. 2019 Feb;20:102-114. doi: 10.1016/j.molmet.2018.11.002. Epub 2018 Nov 15.

PMID: 30482476 Free PMC Article

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Select item 30520520

 

  1. Pulmonary arterial hypertension in a multi-ethnic Asian population: Characteristics, survival and mortality predictors from a 14-year follow-up study.

Lim Y, Low TT, Chan SP, Teo TW, Jang JJ, Yip N, Kuntjoro I, Tay EL, Yip JW.

Respirology. 2019 Feb;24(2):162-170. doi: 10.1111/resp.13392. Epub 2018 Sep 4.

PMID: 30180305 Free Article

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Select item 30562595

 

  1. Clinical Evaluation of Exercise Capacity in Adults with Systemic Right Ventricle.

Rog B, Salapa K, Okolska M, Dluzniewska N, Werynski P, Podolec P, Tomkiewicz-Pajak L.

Tex Heart Inst J. 2019 Feb 1;46(1):14-20. doi: 10.14503/THIJ-17-6408. eCollection 2019 Feb.

PMID: 30833832

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Select item 30166424

 

  1. Substantial Cardiovascular Morbidity in Adults with Lower-Complexity Congenital Heart Disease.

Saha P, Potiny P, Rigdon J, Morello M, Tcheandjieu C, Romfh A, Fernandes SM, McElhinney DB, Bernstein D, Lui GK, Shaw GM, Ingelsson E, Priest JR.

Circulation. 2019 Feb 28. doi: 10.1161/CIRCULATIONAHA.118.037064. [Epub ahead of print]

PMID: 30813762

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Select item 30820038

 

  1. Multi-phase coronary magnetic resonance angiography improves delineation of coronary arteries.

Zitzelsberger T, Krumm P, Hornung A, Kramer U, Nikolaou K, Schäfer JF, Schick F, Sieverding L, Martirosian P.

Acta Radiol. 2019 Feb 24:284185119830289. doi: 10.1177/0284185119830289. [Epub ahead of print]

PMID: 30799635

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Select item 30798610

 

  1. Usefulness of Red Blood Cell Distribution Width in the Assessment of Hemodynamics After Tetralogy of Fallot Repair.

Kojima T, Imamura T, Osada Y, Muraji S, Nakano M, Oyanagi T, Yoshiba S, Kobayashi T, Sumitomo N.

Circ J. 2019 Feb 23. doi: 10.1253/circj.CJ-18-1016. [Epub ahead of print]

PMID: 30799372 Free Article

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Select item 30801777

 

  1. Confirmation of the role of pathogenic SMAD6 variants in bicuspid aortic valve-related aortopathy.

Luyckx I, MacCarrick G, Kempers M, Meester J, Geryl C, Rombouts O, Peeters N, Claes C, Boeckx N, Sakalihasan N, Jacquinet A, Hoischen A, Vandeweyer G, Van Lent S, Saenen J, Van Craenenbroeck E, Timmermans J, Duijnhouwer A, Dietz H, Van Laer L, Loeys B, Verstraeten A.

Eur J Hum Genet. 2019 Feb 22. doi: 10.1038/s41431-019-0363-z. [Epub ahead of print]

PMID: 30796334

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Select item 30796699

  1. Multisite measurement of regional oxygen saturation in Fontan patients with or without protein-losing enteropathy at rest and during exercise.

Schröer S, Fahlbusch FB, Münch F, Alkassar M, Toka HR, Rauh M, Rüffer A, Cesnjevar R, Dittrich S, Okan T, Moosmann J.

Pediatr Res. 2019 Feb 22. doi: 10.1038/s41390-019-0346-3. [Epub ahead of print]

PMID: 30795005

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Select item 30791694

 

  1. Prosthetic pulmonary valve and conduit endocarditis in congenital heart disease.

Rebollal-Leal F, Felipe-Abella R, Gutierrez-García F, A Mestres C, Bautista-Hernandez V.

Asian Cardiovasc Thorac Ann. 2019 Feb 21:218492319832769. doi: 10.1177/0218492319832769. [Epub ahead of print]

PMID: 30791694

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Select item 30791890

 

  1. Research priorities of people living with Turner syndrome.

Sandberg DE, Singer D, Bugajski B, Gebremariam A, Scerbak T, Dooley Maley KL, Scurlock C, Culin D, Eder S, Silberbach M.

Am J Med Genet C Semin Med Genet. 2019 Feb 15. doi: 10.1002/ajmg.c.31676. [Epub ahead of print]

PMID: 30767373

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Select item 30767835

 

  1. Persistent exercise limitation after successful pulmonary endoarterectomy: frequency and determinants.

Corsico AG, D’Armini AM, Conio V, Sciortino A, Pin M, Grazioli V, Di Vincenzo G, Di Domenica R, Celentano A, Vanini B, Grosso A, Gini E, Albicini F, Merli VN, Ronzoni V, Ghio S, Klersy C, Cerveri I.

Respir Res. 2019 Feb 14;20(1):34. doi: 10.1186/s12931-019-1002-5.

PMID: 30764853 Free PMC Article

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Select item 30765829

 

  1. The Turner syndrome research registry: Creating equipoise between investigators and participants.

Prakash SK, Lugo-Ruiz S, Rivera-Dávila M, Rubio N Jr, Shah AN, Knickmeyer RC, Scurlock C, Crenshaw M, Davis SM, Lorigan GA, Dorfman AT, Rubin K, Maslen C, Bamba V, Kruszka P, Silberbach M; Scientific Advisory Board of the TSRR.

Am J Med Genet C Semin Med Genet. 2019 Feb 13. doi: 10.1002/ajmg.c.31689. [Epub ahead of print]

PMID: 30758128

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Select item 30771324

 

  1. Complete Atrioventricular Septal Defect – Evolution of Results in a Single Center during 50 years.

Airaksinen R, Mattila I, Jokinen E, Salminen J, Puntila J, Lehtinen ML, Ojala T, Rautiainen P, Rahkonen O, Suominen P, Pätilä T.

Ann Thorac Surg. 2019 Feb 13. pii: S0003-4975(19)30198-5. doi: 10.1016/j.athoracsur.2019.01.020. [Epub ahead of print]

PMID: 30771324

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Select item 30780116

 

  1. Impact of the Fontan operation on organ systems.

Michel M, Zlamy M, Entenmann A, Pichler K, Scholl-Bürgi S, Karall D, Geiger R, Salvador C, Niederwanger C, Ohuchi H.

Cardiovasc Hematol Disord Drug Targets. 2019 Feb 11. doi: 10.2174/1871529X19666190211165124. [Epub ahead of print]

PMID: 30747084

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Select item 30753614

 

 

  1. Paradoxical nonreentrant tachycardia induced by iatrogenic atrioventricular block.

Roggen M, Garweg C, Willems R, Gewillig M, Ector J.

Acta Cardiol. 2019 Feb 8:1-2. doi: 10.1080/00015385.2018.1521556. [Epub ahead of print] No abstract available.

PMID: 30735477

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Select item 30797558

 

  1. The Janus-faced Fontan circulation: unravelling its elusive pathophysiology.

Ridderbos FS, Hoendermis ES, Berger RMF, van Melle JP.

Eur J Heart Fail. 2019 Feb 7. doi: 10.1002/ejhf.1415. [Epub ahead of print] No abstract available.

PMID: 30730092

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Select item 30738949

 

  1. The placenta: A site of end-organ damage after Fontan operation. A case series.

Phillips AL, Cetta F, Kerr SE, Cheek EH, Rose CH, Bonnichsen CR, Phillips SD.

Int J Cardiol. 2019 Feb 5. pii: S0167-5273(18)35812-1. doi: 10.1016/j.ijcard.2019.02.002. [Epub ahead of print]

PMID: 30765280

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Select item 30716166

 

  1. Child presenting with breathlessness 1 month after cardiac surgery.

Gesuete V, Salis S, Gortani G, Barbi E.

Arch Dis Child Educ Pract Ed. 2019 Feb 1. pii: edpract-2018-316156. doi: 10.1136/archdischild-2018-316156. [Epub ahead of print]

PMID: 30709940

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Select item 30446842

 

  1. Effects of paclitaxel intervention on pulmonary vascular remodeling in rats with pulmonary hypertension.

Zhao J, Yang M, Wu X, Yang Z, Jia P, Sun Y, Li G, Xie L, Liu B, Liu H.

Exp Ther Med. 2019 Feb;17(2):1163-1170. doi: 10.3892/etm.2018.7045. Epub 2018 Dec 5.

PMID: 30679989 Free PMC Article

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Select item 30596289

 

  1. Mode of death and predictors of mortality in adult Fontan survivors: A Japanese multicenter observational study.

Ohuchi H, Inai K, Nakamura M, Park IS, Watanabe M, Hiroshi O, Kim KS, Sakazaki H, Waki K, Yamagishi H, Yamamura K, Kuraishi K, Miura M, Nakai M, Nishimura K, Niwa K; JSACHD Fontan Investigators.

Int J Cardiol. 2019 Feb 1;276:74-80. doi: 10.1016/j.ijcard.2018.09.002. Epub 2018 Sep 5.

PMID: 30201381

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  1. Development and validation of a risk prediction model in patients with adult congenital heart disease.

Baggen VJM, Venema E, Živná R, van den Bosch AE, Eindhoven JA, Witsenburg M, Cuypers JAAE, Boersma E, Lingsma H, Popelová JR, Roos-Hesselink JW.

Int J Cardiol. 2019 Feb 1;276:87-92. doi: 10.1016/j.ijcard.2018.08.059. Epub 2018 Aug 22.

PMID: 30172474

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Select item 30085069

 

  1. Left ventricular function after a Fontan operation in patients with pulmonary atresia with an intact ventricular septum.

Tominaga Y, Kawata H, Iwai S, Yamauchi S, Kugo Y, Hasegawa M, Kayatani F, Takahashi K, Aoki H.

Interact Cardiovasc Thorac Surg. 2019 Feb 1;28(2):273-278. doi: 10.1093/icvts/ivy229.

PMID: 30085069

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Select item 30772962

 

  1. Progressive left ventricular dysfunction and myocardial fibrosis in Duchenne and Becker muscular dystrophy: a longitudinal cardiovascular magnetic resonance study.

Aikawa T, Takeda A, Oyama-Manabe N, Naya M, Yamazawa H, Koyanagawa K, Ito YM, Anzai T.

Pediatr Cardiol. 2019 Feb;40(2):384-392. doi: 10.1007/s00246-018-2046-x. Epub 2018 Dec 18.

PMID: 30564867

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Select item 30539241

 

  1. Differences in Cardiovascular Manifestation of Marfan Syndrome Between Children and Adults.

Wozniak-Mielczarek L, Sabiniewicz R, Drezek-Nojowicz M, Nowak R, Gilis-Malinowska N, Mielczarek M, Łabuc A, Waldoch A, Wierzba J.

Pediatr Cardiol. 2019 Feb;40(2):393-403. doi: 10.1007/s00246-018-2025-2. Epub 2018 Nov 11.

PMID: 30417312

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Select item 30415381

 

ACHD Electrophysiology Featured Articles

ACHD Electrophysiology

 

Congenital and Pediatric Cardiac EP Review for April 2019

 

Extended cardiac ambulatory rhythm monitoring in adults with congenital heart disease: Arrhythmia detection and impact of extended monitoring.

Schultz KE, Lui GK, McElhinney DB, Long J, Balasubramanian V, Sakarovitch C, Fernandes SM, Dubin AM, Rogers IS, Romfh AW, Motonaga KS, Viswanathan MN, Ceresnak SR.

Congenit Heart Dis. 2019 Jan 3. doi: 10.1111/chd.12736. [Epub ahead of print]

PMID:  30604934

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 Take Home Points: 

  • Extended duration ambulatory rhythm monitoring increases the overall yield of arrhythmia findings.
  • Extended duration ambulatory rhythm monitoring may provide additional important data above conventional duration monitoring that can impact clinical management of ACHD patients.

Comment from Dr. Philip Chang (Gainesville, FL), section editor of Congenital Electrophysiology Journal Watch:  This study by Schultz et al retrospectively reviewed the diagnostic yield of extended cardiac ambulatory monitoring (ECAM) devices in a single-center ACHD cohort.  On the premises that arrhythmias are a tremendous source of morbidity and mortality in ACHD and that diagnostic yield of arrhythmias with conventional (≤48-hour) Holter recording is limited, the authors sought to determine the utility and benefit of longer-duration ambulatory rhythm recording in this population.

The study included all ACHD patients >18yo who underwent ECAM device recording using the iRhythm Zio patch between 6/2013 and 5/2016.  The Zio patch is capable of continuous rhythm recording for up to 14 days.  Chart review was performed to gather demographic and clinical data, CHD history, ECG findings, echo data, and EP-related care including antiarrhythmic therapy and EP-related invasive procedures.  Raw data from the ECAM recordings was acquired from the manufacturer along with the indication for ECAM recording.  ECAM data was analyzed to determine when arrhythmias were captured during the recording period, type and burden of arrhythmias, and duration of time that the ECAM was worn.  Lastly, the authors gathered follow-up data after the time of ECAM recording to assess for clinical management changes.

A total of 382 ECAM recordings in 314 patients were reviewed.  A broad variety of CHD types were represented among the study cohort (including 12% single ventricle, 19% TOF, 10% D-TGA) with median age 31y (25-41y IQR).  33% of patients had known significant arrhythmia history.  10% of patients were on amiodarone or another antiarrhythmic medication (not beta blocker/digoxin).  The most common indication for ECAM was patient-reported symptoms in 39% of patients, with an additional 20% having ECAM for a known history of arrhythmias.  28% underwent ECAM for arrhythmia screening only in the setting of CHD.

50% of ECAM recordings revealed significant arrhythmias.  Of these, only 46% occurred within the first 48 hours.  Arrhythmia incidence progressively increased with successive days of ECAM recording (15% incidence at day #1, 62% at day #14).

Arrhythmia incidence on ECAM appeared to be associated with older age (33 vs. 28 years, p <0.0001).  Diagnostic yield was also progressively higher if ECAM recording was performed for a history of arrhythmia, history of symptoms, or the combination of both (Kaplan-Meier plot D).  Left heart obstructive CHD had the highest incidence of arrhythmias (Kaplan-Meier plot A).  Multivariate regression analysis showed age, history of arrhythmia, left heart obstructive CHD, and single ventricle physiology to be significantly associated with arrhythmia recording on ECAM (Table 2).

Finally, the authors reported that 32% of patients with ECAM-captured arrhythmias had a care change as a result of the findings.  57% of care changes were made for arrhythmias diagnosed within 48 hours of ECAM recording, with the remaining occurring in cases with arrhythmia recording beyond 48 hours.

Retrospective design and primary cohort selection bias are probably the 2 biggest limitations to this study.  The high prevalence of arrhythmias in ACHD is well recognized and one third of this single-center cohort had known history of “significant” arrhythmias with 10% already on antiarrhythmic therapy.  As such, it is not surprising that the diagnostic yield from ECAM recording is high.  While the authors report that up to a third of patients had management changes and decisions made based on the ECAM findings obtained beyond the initial 48 hours of recording, the majority of patients had no changes made despite high ECAM incidence of arrhythmias among the entire cohort.  The authors noted that the true clinical significance and impact of arrhythmias captured beyond 48 hours compared to those noted within an initial 48 hours of recording is not entirely clear.  There is lack of clarity in terms of how long the ECAM devices were originally prescribed for vs. how long they were actually worn and no information related to the cost impact of longer-duration recording vs. standard Holter recording.  Finally, this study did not evaluate the yield and impact of the Zio ECAM device compared to other forms of rhythm recording including event recorders or implantable loop recorders.

It is worth noting though that arrhythmia incidence increased progressively over the extended recording period and that a large percentage of ECAM’s that eventually recorded significant arrhythmias did so after 48 hours.  These 2 findings are certainly in line with other studies that have demonstrated the utility and improved screening efficacy of longer- or extended-duration ambulatory rhythm recording above conventional 24- or 48-hour Holter monitoring.  ECAM therefore is of better screening utility and quantification of arrhythmia burden compared to shorter-duration, conventional Holter recording.  These will likely prove to be useful in serial and long-term rhythm screening in the ACHD population.

 

CHD EP Feb 2019

 

  1. Characterization of the Mechanism and Substrate of Atrial Tachycardia Using Ultra-High-Density Mapping in Adults With Congenital Heart Disease: Impact on Clinical Outcomes.

Mantziari L, Butcher C, Shi R, Kontogeorgis A, Opel A, Chen Z, Haldar S, Panikker S, Hussain W, Jones DG, Gatzoulis MA, Markides V, Ernst S, Wong T.

J Am Heart Assoc. 2019 Feb 19;8(4):e010535. doi: 10.1161/JAHA.118.010535.

PMID: 30773973 Free Article

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  1. Paradoxical nonreentrant tachycardia induced by iatrogenic atrioventricular block.

Roggen M, Garweg C, Willems R, Gewillig M, Ector J.

Acta Cardiol. 2019 Feb 8:1-2. doi: 10.1080/00015385.2018.1521556. [Epub ahead of print] No abstract available.

PMID: 30735477

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  1. The Real-World Utility of the LINQ Implantable Loop Recorder in Pediatric and Adult Congenital Heart Patients.

Bezzerides VJ, Walsh A, Martuscello M, Escudero CA, Gauvreau K, Lam G, Abrams DJ, Triedman JK, Alexander ME, Bevilacqua L, Mah DY.

JACC Clin Electrophysiol. 2019 Feb;5(2):245-251. doi: 10.1016/j.jacep.2018.09.016.

PMID: 30784698

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  1. Atrioventricular reentrant tachycardia in a child with tricuspid atresia: A case report of catheter ablation.

Wang Y, Liu Q, Deng X, Xiao Y, Chen Z.

Medicine (Baltimore). 2019 Feb;98(6):e14320. doi: 10.1097/MD.0000000000014320.

PMID: 30732151 Free PMC Article

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  1. A minimally invasive hybrid approach for cardiac resynchronization of the systemic right ventricle.

Moore JP, Gallotti RG, Shannon KM, Biniwale R.

Pacing Clin Electrophysiol. 2019 Feb;42(2):171-177. doi: 10.1111/pace.13568. Epub 2018 Dec 13.

PMID: 30520520

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  1. Ultrasound-guided axillary venous access for pediatric and adult congenital lead implantation.

Clark BC, Janson CM, Nappo L, Pass RH.

Pacing Clin Electrophysiol. 2019 Feb;42(2):166-170. doi: 10.1111/pace.13567. Epub 2018 Dec 27.

PMID: 30515865

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  1. Catheter ablation for atrial fibrillation and intervention for pulmonary vein stenosis in a patient with Fontan circulation.

Uhm JS, Choi JY, Kim YJ, Kim TH, Joung B, Pak HN, Lee MH.

Pacing Clin Electrophysiol. 2019 Feb;42(2):113-116. doi: 10.1111/pace.13515. Epub 2018 Oct 17.

PMID: 30264868

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  1. [Congenital heart block revealing a maternal systemic disease : pathophysiology and therapeutic approaches].

Collée J, Malaise O, Emonts P, Seghaye MC, Van Linthout C.

Rev Med Liege. 2019 Feb;74(2):95-99. French.

PMID: 30793563

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  1. Minimally Invasive Percutaneous Epicardial Placement of a Prototype Miniature Pacemaker with Leadlet under Direct Visualization: A Feasibility Study in an Infant Porcine Model.

Kumthekar RN, Opfermann JD, Mass P, Clark BC, Moak JP, Sherwin ED, Whitman T, Marshall M, Berul CI.

Heart Rhythm. 2019 Feb 28. pii: S1547-5271(19)30207-3. doi: 10.1016/j.hrthm.2019.02.033. [Epub ahead of print]

PMID: 30826423

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  1. QT Interval Prolongation in the Pediatric Oncologic Population on Methadone.

Piccininni JA, Killinger JS, Hammad HT, Gerber LM, Dayton JD.

J Pediatr Hematol Oncol. 2019 Feb 28. doi: 10.1097/MPH.0000000000001444. [Epub ahead of print]

PMID: 30830033

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  1. Hazards of ventricular pre-excitation to left ventricular systolic function and ventricular wall motion in children: analysis of 25 cases.

Guo B, Dai C, Li Q, Li W, Han L.

Cardiol Young. 2019 Feb 15:1-9. doi: 10.1017/S1047951118002500. [Epub ahead of print]

PMID: 30767835

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Select item 30768157

 

  1. Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients.

Shimizu W, Makimoto H, Yamagata K, Kamakura T, Wada M, Miyamoto K, Inoue-Yamada Y, Okamura H, Ishibashi K, Noda T, Nagase S, Miyazaki A, Sakaguchi H, Shiraishi I, Makiyama T, Ohno S, Itoh H, Watanabe H, Hayashi K, Yamagishi M, Morita H, Yoshinaga M, Aizawa Y, Kusano K, Miyamoto Y, Kamakura S, Yasuda S, Ogawa H, Tanaka T, Sumitomo N, Hagiwara N, Fukuda K, Ogawa S, Aizawa Y, Makita N, Ohe T, Horie M, Aiba T.

JAMA Cardiol. 2019 Feb 13. doi: 10.1001/jamacardio.2018.4925. [Epub ahead of print]

PMID: 30758498

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Select item 30758099

 

  1. Exercise testing oversights underlie missed and delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia in young sudden cardiac arrest survivors.

Giudicessi JR, Ackerman MJ.

Heart Rhythm. 2019 Feb 11. pii: S1547-5271(19)30120-1. doi: 10.1016/j.hrthm.2019.02.012. [Epub ahead of print]

PMID: 30763784

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Select item 30763738

 

  1. Electroanatomic mapping-guided catheter ablation of atrial tachycardia in children with limited/zero fluoroscopy.

Elkiran O, Akdeniz C, Karacan M, Tuzcu V.

Pacing Clin Electrophysiol. 2019 Feb 10. doi: 10.1111/pace.13619. [Epub ahead of print]

PMID: 30740745

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  1. Transseptal Puncture for Catheter Ablation in Children.

Koca S, Akdeniz C, Tuzcu V.

Pediatr Cardiol. 2019 Feb 7. doi: 10.1007/s00246-019-02069-4. [Epub ahead of print]

PMID: 30729261

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Select item 30729260

 

 

  1. Baroreceptor activity and sensitivity: normal values in children and young adults using the head up tilt test.

Alnoor MS, Varner HK, Butler IJ, Zhu L, Numan MT.

Pediatr Res. 2019 Feb 6. doi: 10.1038/s41390-019-0327-6. [Epub ahead of print]

PMID: 30728445

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Select item 30722073

 

  1. [Clinical analysis of right atrial appendage aneurysms complicated by atrial tachyarrhythmias in three children].

Zhang Y, Li XM, Jiang H, Zhang FQ, Jin YQ, Liu HJ, Ge HY.

Zhonghua Er Ke Za Zhi. 2019 Feb 2;57(2):98-102. doi: 10.3760/cma.j.issn.0578-1310.2019.02.007. Chinese.

PMID: 30695882

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Select item 30695881

 

  1. Percutaneous pericardial access for electrophysiological studies in patients with prior cardiac surgery: approach and understanding the risks.

Killu AM, Asirvatham SJ.

Expert Rev Cardiovasc Ther. 2019 Feb;17(2):143-150. doi: 10.1080/14779072.2019.1561276. Epub 2018 Dec 29. Review.

PMID: 30596289

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Select item 30614292

 

  1. Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia.

Lieve KVV, Verhagen JMA, Wei J, Bos JM, van der Werf C, Rosés I Noguer F, Mancini GMS, Guo W, Wang R, van den Heuvel F, Frohn-Mulder IME, Shimizu W, Nogami A, Horigome H, Roberts JD, Leenhardt A, Crijns HJG, Blank AC, Aiba T, Wiesfeld ACP, Blom NA, Sumitomo N, Till J, Ackerman MJ, Chen SRW, van de Laar IMBH, Wilde AAM.

Heart Rhythm. 2019 Feb;16(2):220-228. doi: 10.1016/j.hrthm.2018.08.025. Epub 2018 Aug 28.

PMID: 30170228

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Select item 30125718

 

  1. The anatomic substrates for outflow tract arrhythmias.

Anderson RH, Mohun TJ, Sánchez-Quintana D, Mori S, Spicer DE, Cheung JW, Lerman BB.

Heart Rhythm. 2019 Feb;16(2):290-297. doi: 10.1016/j.hrthm.2018.08.014. Epub 2018 Aug 18.

PMID: 30125718

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Select item 30155660

 

  1. A minimally invasive hybrid approach for cardiac resynchronization of the systemic right ventricle.

Moore JP, Gallotti RG, Shannon KM, Biniwale R.

Pacing Clin Electrophysiol. 2019 Feb;42(2):171-177. doi: 10.1111/pace.13568. Epub 2018 Dec 13.

PMID: 30520520

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Select item 30515872

 

  1. Optimizing resynchronization pacing in the failing systemic right ventricle.

Karpawich PP.

Pacing Clin Electrophysiol. 2019 Feb;42(2):178-179. doi: 10.1111/pace.13560. Epub 2019 Jan 14. No abstract available.

PMID: 30515872

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  1. Fetal Arrhythmias: Genetic Background and Clinical Implications.

Yuan SM.

Pediatr Cardiol. 2019 Feb;40(2):247-256. doi: 10.1007/s00246-018-2008-3. Epub 2018 Nov 26. Review.

PMID: 30478614

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  1. Ventricular arrhythmia: A feature of tubercular myocarditis.

Awasthy N, Garg R, Goel A, Bhatia M, Radhakrishnan S.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):53-55. doi: 10.4103/apc.APC_123_13.

PMID: 30745771 Free PMC Article

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ACHD Interventional Cardiology Featured Articles

ACHD Interventions

Interventional Cardiology Reviews of February 2019 Manuscripts

 

Fate of the Fontan connection: Mechanisms of stenosis and management.

Hagler DJ, Miranda WR, Haggerty BJ, Anderson JH, Johnson JN, Cetta F, Said SM, Taggart NW.

Congenit Heart Dis. 2019 Feb 25. doi: 10.1111/chd.12757. [Epub ahead of print]

PMID: 30801968 

Take Home Points: 

  • Stenosis of the Fontan IVC – PA connection may not be recognized on routine echocardiographic imaging and may require assessment via CT or MRI.
  • Percutaneous treatment of Fontan connection stenosis is safe, feasible and may improve patients’ clinical status.
  • Fontan patients may benefit for routine invasive assessment after Fontan completion.

Commentary from Dr. Konstantin Averin (Edmonton), catheterization section editor of Pediatric Cardiology Journal Watch:  The Fontan procedure is performed with the goal of providing an unobstructed pathway for inferior vena cava (IVC) flow to the pulmonary arteries (PAs). Obstruction of this connection can exacerbate the risks of developing Fontan failure and end-organ injury and should be addressed in a timely fashion. Data on the mechanisms of IVC-PA obstruction and the safety, efficacy and mid-term outcomes of percutaneous intervention are limited. The authors sought to describe a single center experience with intervention on the IVC-PA conduit.

From January 2002 to October 2018 28 patients had conduit obstruction identified (12% of all Fontan catheterizations, 2.5% of all Fontan patients) with 20 meeting inclusion criteria. The median age at catheterization was 17 years, time from Fontan 13 years and weight 59 kg. The most common type of conduit was an extra-cardiac homograft (10/20), followed by extra-cardiac Gore-Tex (6/20), intra-atrial conduit Gore-Tex (1/20), and a lateral tunnel type connection (3/20). More than 50% of patients had evidence of liver cirrhosis. Most patients (12/20) had a single stent implanted with a variety of stents used (covered CP, Palmaz XL/XD, and Intrastent Max LD). The median Fontan diameter increased from 10.5 mm to 18 mm with a decrease in the pressure gradient from 2 mmHg to 0 mmHg.

There were no serious adverse events related to stent implant with 2 patients experiencing small extravasations treated with covered stent implant. A sustained improvement in functional capacity was observed in 11/20 patient’s post-stent with PLE resolution observed in 2/4. No follow up data was presented regarding liver cirrhosis post-stent implant.

The authors conclude that IVC-PA conduit obstruction can be treated safely and effectively with possible improvement in clinical status post-intervention. The authors discuss that there are various mechanisms of stenosis – calcification with luminal narrowing, conduit stretching due to somatic growth, and anastomotic narrowing. Interestingly the authors comment that many of the patients did not have clearly recognized conduit obstruction pre-procedure (6 with no cross sectional imaging and the rest with cross sectional imaging without a clear appreciation of the degree of narrowing). It seems clear that optimizing the IVC to PA connection (targeting a size of 18-20mm) is a critical part of optimizing end-organ health and forestalling the development of long-term Fontan complications.

 

Classification scheme for ductal morphology in cyanotic patients with ductal dependent pulmonary blood flow and association with outcomes of patent ductus arteriosus stenting.

Qureshi AM, Goldstein BH, Glatz AC, Agrawal H, Aggarwal V, Ligon RA, McCracken C, McDonnell A, Buckey TM, Whiteside W, Metcalf CM, Petit CJ.

Catheter Cardiovasc Interv. 2019 Feb 21. doi: 10.1002/ccd.28125. [Epub ahead of print]

PMID: 30790426

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Select item 30791188

Take Home Points 

  • PDA stent implantation is an increasingly utilized initial intervention for infants with ductal dependent pulmonary blood flow.
  • The degree of ductal tortuosity is an important predictor of need for unplanned reintervention and branch pulmonary artery jailing but does not predict successful PDA stenting (ductal stenting was equally successful regardless of tortuosity).
  • Pulmonary artery arterioplasty is performed more often when branch PAs are jailed, though indices of PA growth are not affected in a jailed branch PA.

Commentary from Dr. Ryan Romans (Kansas City), catheterization section editor of Pediatric Cardiology Journal Watch:  Stent implantation in the patent ductus arteriosus (PDA) has become a more frequently used initial intervention in infants with ductal dependent pulmonary blood flow (PBF). The ductal anatomy in these patients can vary significantly and may play a role in the success of PDA stenting. PDA tortuosity is often seen as a contraindication to ductal stenting, though this has not been well studied. Additionally, reinterventions are fairly common in patients who have undergone PDA stenting. Risk factors for need for reintervention and procedural results that predict future outcomes (such as pulmonary artery (PA) jailing and impact on future PA growth or need for surgical PA plasty) have not been well defined.

Qureshi et al report on a multicenter retrospective cohort study of all patients less than 1 year of age with ductal dependent PBF with confluent branch pulmonary arteries who underwent transcatheter PDA stent implantation over a 7 year period. A classification scheme based on ductal morphology was created based on 3 distinct tortuosity index (TI) groups as detailed below. An additional subtype classification was made based on the ductal origin (descending aorta, underside of aortic arch, innominate artery, or ascending aorta). A curvature index (CI) was also calculated using the total length of the PDA and the length of a straight line from the aortic origin to the PA insertion (higher ratios indicate increased ductal curvature).

A total of 105 patients underwent PDA stent implantation with a total of 157 stents across the 4 centers. The catheterization access sites varied (carotid, axillary, and femoral) depending on the location of the ductal origin. 40% of patients had expected single ventricle anatomy and nearly 40% had the PDA as their only source of pulmonary blood flow. The tortuosity index was type I in 55%, type II in 23%, and type 3 in 22%. Not surprisingly, patients with a higher TI tended to have a higher CI. There was no significant difference in procedure times (defined as time of sheath insertion to sheath removal) or need to implant more than 1 stent among the different PDA tortuosity types. Jailing of a branch PA (defined as partial when there was any stent protrusion into the orifice of a branch PA, or complete when a stent crossed the entire branch PA orifice) was seen in 22% of patients (19 patients with partial jailing, 4 with complete, though with preserved flow to the jailed PA). There was a higher incidence of PA jailing as the TI increased. Over a median follow up time of 13.5 months (IQR 6.9-37 months), 36% patients underwent planned reinterventions (typically PDA stent redilation at times determined by each individual center) and 11% of patients underwent unplanned reinterventions to treat cyanosis. Increased TI and the presence of PA jailing were associated more unplanned reinterventions. While there was no significant difference in indices of PA growth (Nakata index and pulmonary artery symmetry index) in patients who had PAs jailed, these patients were more likely to have PA plasty performed at the time of their next surgery.  64 patients underwent complete anatomic repair or stage II palliation.

This retrospective cohort study reports a novel standardized PDA classification scheme for infants with ductal dependent PBF. PDA stenting was successful across the range of PDA morphologies, though PDAs with a higher TI that were stented were more at risk for branch PA jailing (which increases the likelihood of PA arterioplasty) and needing unplanned reinterventions. However, initial technical success did not vary between groups in contrary to the oft held belief that tortuous ducts are not amenable to stenting. Additionally, even if the PAs were jailed, the indices of PA growth did not suffer. The authors acknowledge (and I certainly agree) that there is a learning curve for clinicians who perform ductal stenting. However, this study and other recently published data showing a favorable comparison of PDA stenting to surgical shunts indicating ductal stenting will continue to play a large role in the initial management of patients with ductal dependent PBF.

 

 

 

CHD Interventions Feb 2019

 

  1. Fate of the Fontan connection: Mechanisms of stenosis and management.

Hagler DJ, Miranda WR, Haggerty BJ, Anderson JH, Johnson JN, Cetta F, Said SM, Taggart NW.

Congenit Heart Dis. 2019 Feb 25. doi: 10.1111/chd.12757. [Epub ahead of print]

PMID: 30801968

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  1. Classification scheme for ductal morphology in cyanotic patients with ductal dependent pulmonary blood flow and association with outcomes of patent ductus arteriosus stenting.

Qureshi AM, Goldstein BH, Glatz AC, Agrawal H, Aggarwal V, Ligon RA, McCracken C, McDonnell A, Buckey TM, Whiteside W, Metcalf CM, Petit CJ.

Catheter Cardiovasc Interv. 2019 Feb 21. doi: 10.1002/ccd.28125. [Epub ahead of print]

PMID: 30790426

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  1. Trends in surgical and catheter interventions for isolated congenital shunt lesions in the UK and Ireland.

Farooqi M, Stickley J, Dhillon R, Barron DJ, Stumper O, Jones TJ, Clift PF, Brawn WJ, Drury NE.

Heart. 2019 Feb 16. pii: heartjnl-2018-314428. doi: 10.1136/heartjnl-2018-314428. [Epub ahead of print]

PMID: 30772822 Free Article

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  1. Initial results from the off-label use of the SAPIEN S3 valve for percutaneous transcatheter pulmonary valve replacement: A multi-institutional experience.

Sinha S, Aboulhosn J, Asnes J, Bocks M, Zahn E, Goldstein BH, Zampi J, Hellenbrand W, Salem M, Levi D.

Catheter Cardiovasc Interv. 2019 Feb 15;93(3):455-463. doi: 10.1002/ccd.27973. Epub 2018 Dec 7.

PMID: 30537348

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  1. Hybrid transcatheter tricuspid valve-in-valve placement of an Edwards Sapien XT valve in palliated hypoplastic left heart syndrome.

Ho AB, Kaarne M, Mullen M, Hayes N.

Catheter Cardiovasc Interv. 2019 Feb 15;93(3):481-483. doi: 10.1002/ccd.27910. Epub 2018 Nov 12.

PMID: 30419610

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  1. Implantation of the Melody transcatheter pulmonary valve PB1016 in patients with dysfunctional right ventricular outflow tract conduits.

Morray BH, Jones TK, Coe JY, Gitter R, Martinez JZ, Turner DR, Gray RG, Lung TH, Berman DP, Levi DS.

Catheter Cardiovasc Interv. 2019 Feb 15;93(3):474-480. doi: 10.1002/ccd.27974. Epub 2018 Nov 12.

PMID: 30419603

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  1. Modified delivery of SAPIEN 3 valve in the pulmonary position: Evolution of technique or dire need?

Shahanavaz S, Rockefeller T, Nicolas R, Balzer D.

Catheter Cardiovasc Interv. 2019 Feb 15;93(3):484-487. doi: 10.1002/ccd.27946. Epub 2018 Nov 8.

PMID: 30408317

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  1. Temporary balloon occlusion of atrial septal defects in suspected or documented left ventricular diastolic dysfunction: Hemodynamic and clinical findings.

Miranda WR, Hagler DJ, Reeder GS, Warnes CA, Connolly HM, Egbe AC, Taggart NW.

Catheter Cardiovasc Interv. 2019 Feb 12. doi: 10.1002/ccd.28150. [Epub ahead of print]

PMID: 30747481

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  1. Fetal Intracardiac Hemodynamic Measurements Using Pressure Guidewire During Fetal Atrial Septal Stent Placement.

Whiteside W, Gelehrter SK, Fifer CG, Rocchini AP, Van de Ven C, Treadwell MC, Wu K, Zampi JD.

JACC Cardiovasc Interv. 2019 Feb 11;12(3):e25-e26. doi: 10.1016/j.jcin.2018.11.037. Epub 2019 Jan 16. No abstract available.

PMID: 30660455

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  1. A Model for Assessment of Catheterization Risk in Adults With Congenital Heart Disease.

Taggart NW, Du W, Forbes TJ, Nykanen DG, Wax DF, Cabalka AK, Reeves JH, Du Y, Kobayashi D.

Am J Cardiol. 2019 Feb 8. pii: S0002-9149(19)30172-9. doi: 10.1016/j.amjcard.2019.01.042. [Epub ahead of print]

PMID: 30797558

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  1. Working backward: Retrograde balloon angioplasty of atretic arteries in chronic thromboembolic pulmonary hypertension.

Allen Ligon R, Petit CJ.

Catheter Cardiovasc Interv. 2019 Feb 5. doi: 10.1002/ccd.28115. [Epub ahead of print]

PMID: 30723998

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  1. Successful everolimus-eluting stent implantation into the left main trunk stenosis in the anomalous coronary artery after neo-aortic valve replacement in a 6-year-old boy.

Asada D, Tomita H, Fujii T.

Cardiol Young. 2019 Feb 4:1-3. doi: 10.1017/S1047951118002512. [Epub ahead of print]

PMID: 30714565

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Select item 30714327

 

  1. SAPIEN valve for percutaneous transcatheter pulmonary valve replacement without “pre-stenting”: A multi-institutional experience.

Morgan GJ, Sadeghi S, Salem MM, Wilson N, Kay J, Rothman A, Galindo A, Martin MH, Gray R, Ross M, Aboulhosn JA, Levi DS.

Catheter Cardiovasc Interv. 2019 Feb 1;93(2):324-329. doi: 10.1002/ccd.27932. Epub 2018 Oct 23.

PMID: 30351525

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Select item 29746156Transcatheter heart valve interventions: where are we? Where are we going?

Prendergast BD, Baumgartner H, Delgado V, Gérard O, Haude M, Himmelmann A, Iung B, Leafstedt M, Lennartz J, Maisano F, Marinelli EA, Modine T, Mueller M, Redwood SR, Rörick O, Sahyoun C, Saillant E, Søndergaard L, Thoenes M, Thomitzek K, Tschernich M, Vahanian A, Wendler O, Zemke EJ, Bax JJ.

Eur Heart J. 2019 Feb 1;40(5):422-440. doi: 10.1093/eurheartj/ehy668.

PMID: 30608523

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  1. Successful treatment of esophageal bleeding due to rupture of major aortopulmonary collateral arteries by transcatheter arterial embolization.

Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Matsushima M, Kato T, Hirooka Y.

Clin J Gastroenterol. 2019 Feb;12(1):20-24. doi: 10.1007/s12328-018-0895-8. Epub 2018 Aug 21.

PMID: 30132302

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Select item 29611724

 

  1. Transcatheter heart valve interventions: where are we? Where are we going?

Prendergast BD, Baumgartner H, Delgado V, Gérard O, Haude M, Himmelmann A, Iung B, Leafstedt M, Lennartz J, Maisano F, Marinelli EA, Modine T, Mueller M, Redwood SR, Rörick O, Sahyoun C, Saillant E, Søndergaard L, Thoenes M, Thomitzek K, Tschernich M, Vahanian A, Wendler O, Zemke EJ, Bax JJ.

Eur Heart J. 2019 Feb 1;40(5):422-440. doi: 10.1093/eurheartj/ehy668.

PMID: 30608523

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Select item 30602001

 

  1. First-in-man pulmonary artery stenting in children using the Bentley® BeGrow™ stent system for newborns and infants.

Quandt D, Knirsch W, Michel-Behnke I, Kitzmüller E, Obradovic M, Uhlemann F, Kretschmar O.

Int J Cardiol. 2019 Feb 1;276:107-109. doi: 10.1016/j.ijcard.2018.11.029. Epub 2018 Nov 19.

PMID: 30477928 Free Article

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Select item 30413301

 

  1. Transcatheter cardiac interventions in neonates with congenital heart disease: A single centre experience.

Melekoglu AN, Baspinar O.

J Int Med Res. 2019 Feb;47(2):615-625. doi: 10.1177/0300060518806111. Epub 2018 Oct 30.

PMID: 30373426 Free PMC Article

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Select item 30396684

 

  1. Stent angioplasty for treatment of canine valvular pulmonic stenosis.

Sosa I, Swift ST, Jones AE, Estrada AH, Fudge JC.

J Vet Cardiol. 2019 Feb;21:41-48. doi: 10.1016/j.jvc.2018.10.007. Epub 2018 Dec 12.

PMID: 30797444

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Select item 30784698

 

  1. Orchestrating a Symphony-Fetal and Transitional Interventions for Congenital Heart Disease.

Jacobs ML.

Mayo Clin Proc. 2019 Feb;94(2):194-198. doi: 10.1016/j.mayocp.2018.12.013. No abstract available.

PMID: 30711117

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Select item 30732151

 

  1. Three-Dimensional Rotational Angiography in Pediatric Patients with Congenital Heart Disease: A Literature Review.

van der Stelt F, Siegerink SN, Krings GJ, Molenschot MMC, Breur JMPJ.

Pediatr Cardiol. 2019 Feb;40(2):257-264. doi: 10.1007/s00246-019-02052-z. Epub 2019 Jan 24.

PMID: 30680421

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Select item 30506273

 

  1. Radiation Risk Categories in Cardiac Catheterization for Congenital Heart Disease: A Tool to Aid in the Evaluation of Radiation Outcomes.

Quinn BP, Armstrong AK, Bauser-Heaton HD, Callahan R, El-Said HG, Foerster SR, Goldstein BH, Goodman AS, Gudausky TM, Kreutzer JN, Leahy RA, Petit CJ, Rockefeller TA, Shahanavaz S, Trucco SM, Bergersen L; Congenital Cardiac Catheterization Project on Outcomes-Quality Improvement (C3PO-QI).

Pediatr Cardiol. 2019 Feb;40(2):445-453. doi: 10.1007/s00246-018-2024-3. Epub 2018 Nov 30.

PMID: 30506273

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Select item 30498851

 

  1. Life-Saving Stenting of Pulmonary Arteries Critically Narrowed by Mediastinal Lymphoma.

Trejnowska E, Fiszer R, Armatowicz P, Tarczyńska-Słomian M, Wiklińska A, Kurdyś P, Ślusarz K, Kocaj K, Knapik P.

Am J Respir Crit Care Med. 2019 Feb 26. doi: 10.1164/rccm.201807-1366IM. [Epub ahead of print] No abstract available.

PMID: 30807202

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Select item 30808315

 

  1. Percutaneous PDA closure with Amplatzer AVP ll and ADO ll AS devices.

Lucas VS.

Catheter Cardiovasc Interv. 2019 Feb 15;93(3):E197. doi: 10.1002/ccd.28002.

PMID: 30770669

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Select item 30537348

 

  1. Toward predictive modeling of catheter-based pulmonary valve replacement into native right ventricular outflow tracts.

Jolley MA, Lasso A, Nam HH, Dinh PV, Scanlan AB, Nguyen AV, Ilina A, Morray B, Glatz AC, McGowan FX, Whitehead K, Dori Y, Gorman JH 3rd, Gorman RC, Fichtinger G, Gillespie MJ.

Catheter Cardiovasc Interv. 2019 Feb 15;93(3):E143-E152. doi: 10.1002/ccd.27962. Epub 2018 Nov 15.

PMID: 30444053

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Select item 30419611

 

  1. Feasibility, safety and midterm follow-up of patients after nonsurgical closure of atrial septal defects using very large 40-46 mm nitinol septal occluders.

Sivakumar K, Viswambaran B, Bhattacharjya S.

Catheter Cardiovasc Interv. 2019 Feb 15;93(3):466-473. doi: 10.1002/ccd.27957. Epub 2018 Nov 12.

PMID: 30419611

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Select item 30419603

 

  1. Upper-Extremity Venous Access for Children and Adults in Pediatric Cardiac Catheterization Laboratory.

Randall JT, Aldoss O, Khan A, Challman M, Hiremath G, Qureshi AM, Bansal M.

J Invasive Cardiol. 2019 Feb 15. pii: JIC2019215-1. [Epub ahead of print]

PMID: 30765619 Free Article

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Select item 30770935

 

  1. The definition of a hemodynamically significant ductus arteriosus.

El-Khuffash A, Levy PT, Gorenflo M, Frantz ID 3rd.

Pediatr Res. 2019 Feb 15. doi: 10.1038/s41390-019-0342-7. [Epub ahead of print] No abstract available.

PMID: 30770863

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Select item 30789401

 

  1. Fetal Intracardiac Hemodynamic Measurements Using Pressure Guidewire During Fetal Atrial Septal Stent Placement.

Whiteside W, Gelehrter SK, Fifer CG, Rocchini AP, Van de Ven C, Treadwell MC, Wu K, Zampi JD.

JACC Cardiovasc Interv. 2019 Feb 11;12(3):e25-e26. doi: 10.1016/j.jcin.2018.11.037. Epub 2019 Jan 16. No abstract available.

PMID: 30660455

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Select item 30743276

 

  1. Stent-retriever thrombectomy in the treatment of infants with acute thrombosis of the superior vena cava and innominate vein.

Hanser A, Sieverding L, Hauser TK, Wiegand G, Hofbeck M.

Catheter Cardiovasc Interv. 2019 Feb 9. doi: 10.1002/ccd.28142. [Epub ahead of print]

PMID: 30737974

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Select item 30739224

 

  1. Transthoracic access for pulmonary artery stenting.

Krasemann T, van Beynum I, van de Woestijne P, Bogers A.

Cardiol Young. 2019 Feb;29(2):222-224. doi: 10.1017/S1047951118001841. Epub 2018 Dec 4.

PMID: 30511605

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Select item 30511601

 

  1. Further percutaneous dilation of a Melody® valve in the mitral position to accommodate somatic growth in a small child: lessons learned.

Sullivan PM, Wong PC, Kim R, Ing FF.

Cardiol Young. 2019 Feb;29(2):235-237. doi: 10.1017/S1047951118001944. Epub 2018 Dec 4.

PMID: 30511601

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Select item 30511599

 

  1. A randomized, controlled, multi-center trial of the efficacy and safety of the Occlutech Figulla Flex-II Occluder compared to the Amplatzer Septal Occluder for transcatheter closure of secundum atrial septal defects.

Kenny D, Eicken A, Dähnert I, Boudjemline Y, Sievert H, Schneider MB, Gori T, Hijazi ZM; Investigators.

Catheter Cardiovasc Interv. 2019 Feb 1;93(2):316-321. doi: 10.1002/ccd.27899. Epub 2018 Nov 4.

PMID: 30719850

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Select item 30380204

 

  1. Melody valve in mitral position: Complete fracture causing acute mitral stenosis in a child.

Morrical BD, Dearani JA, Cabalka AK.

Catheter Cardiovasc Interv. 2019 Feb 1;93(2):E101-E104. doi: 10.1002/ccd.27683. Epub 2018 Oct 31.

PMID: 30380204

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Select item 30351525

 

  1. SAPIEN valve for percutaneous transcatheter pulmonary valve replacement without “pre-stenting”: A multi-institutional experience.

Morgan GJ, Sadeghi S, Salem MM, Wilson N, Kay J, Rothman A, Galindo A, Martin MH, Gray R, Ross M, Aboulhosn JA, Levi DS.

Catheter Cardiovasc Interv. 2019 Feb 1;93(2):324-329. doi: 10.1002/ccd.27932. Epub 2018 Oct 23.

PMID: 30351525

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Select item 30755054

 

  1. Predictive factors for residual hypertension following aortic coarctation stenting.

Iriart X, Laïk J, Cremer A, Martin C, Pillois X, Jalal Z, Roubertie F, Thambo JB.

J Clin Hypertens (Greenwich). 2019 Feb;21(2):291-298. doi: 10.1111/jch.13452. Epub 2018 Dec 25.

PMID: 30585428 Free Article

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Select item 30614814

 

  1. Bronchial compression as adverse effect of right pulmonary artery stenting in a patient with truncus arteriosus communis and interrupted aortic arch.

Takeuchi K, Srivastava A, Steed DR.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):66-68. doi: 10.4103/apc.APC_63_18.

PMID: 30745775 Free PMC Article

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Select item 30745774

 

  1. Novel use of covered stents to treat profound cyanosis in a hepatic vein exclusion Fontan.

Batlivala SP, Ebeid MR.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):60-63. doi: 10.4103/apc.APC_125_18.

PMID: 30745773 Free PMC Article

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ACHD Surgery

ACHD Surgery

Congenital Heart Surgery Reviews of February 2019 Manuscripts

Current Challenges and Emergent Technologies for Manufacturing Artificial Right Ventricle to Pulmonary Artery (RV-PA) Cardiac Conduits.

Manavitehrani I, Ebrahimi P, Yang I, Daly S, Schindeler A, Saxena A, Little DG, Fletcher DF, Dehghani F, Winlaw DS.

Cardiovasc Eng Technol. 2019 Feb 14. doi: 10.1007/s13239-019-00406-5. [Epub ahead of print] Review.

PMID: 30767113

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Take-Home Points:

 This article is a helpful review of current challenges and future directions of the development of optimal conduits for right ventricular outflow tract reconstruction.

 Commentary from Dr. Jeremy Herrmann (Indianapolis), section editor of Congenital Heart Surgery Journal Watch:  Right ventricular outflow tract reconstruction procedures remain one of the most common congenital cardiac surgical procedure performed in children and adults, though the optimal conduit type remains elusive. Manavitehrani and colleagues provide an excellent comprehensive review about this topic, in which they highlight the inherent limitations and challenges of selecting and/or designing conduits. Few clinical data or summaries are provided, though these are beyond the scope of this paper. The authors review the natural characteristics of pulmonary arterial tissue including its biomechanical properties. The evolution of the current landscape of conduit choices is described along with the relevant limitations of current conduit choices including lack of growth potential and biomechanical differences in implanted native and xeno- or allograft material. The authors look ahead at tissue engineering options including scaffold-based processes with various natural and synthetic biomaterials as well as recent advances in electrospinning, 3D printing, and bioprinting. Newer advancements may allow for replacement of the graft material with native tissue, growth with the patient’s somatic size, and improved compliance. However, these process are challenged of incorporating natural cells for tissue differentiation and how to accurately guide cell behavior.  Any of these strategies must provide long-term functional replacement that will be readily functional at the time of implantation. Finally, the authors discuss the role of computational fluid dynamics and modeling in designing and evaluating optimal conduits. Much of the discussion centers around what is currently employed at a few centers for the Fontan procedure, and the extension of this application to RVOT procedures is not difficult to imagine.

 

 

  1. Homografts versus stentless bioprosthetic valves in the pulmonary position: a multicentre propensity-matched comparison in patients younger than 20 years.

Marathe SP, Bell D, Betts K, Sayed S, Dunne B, Ward C, Whight C, Jalali H, Venugopal P, Andrews D, Alphonso N.

Eur J Cardiothorac Surg. 2019 Feb 7. doi: 10.1093/ejcts/ezz021. [Epub ahead of print]

PMID: 30753373

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Select item 30729809 

Take-Home Points: 

  • In this retrospective study of right ventricular outflow tract reconstruction, Freestyle valves and pulmonary homograft exhibited similar freedom from reintervention and structural valve degeneration up to 10 years after placement. Beyond 10 years, the pulmonary homografts exhibited better performance in these categories.
  • However, it is difficult to compare results from this and other small studies that utilize a limited number of available conduits with varying techniques. 

Commentary from Dr. Jeremy Herrmann (Indianapolis), section editor of Congenital Heart Surgery Journal Watch:  The discussion about which conduit for right ventricular outflow tract reconstruction remains undecided. Evidence continues to slowly grow, but long-term data for the Freestyle porcine aortic valve use for pulmonary valve position are limited. In this study, the group from University of Queensland in Brisbane, Australia, provides a comparison of longer term outcomes of patients <20 years who underwent pulmonary valve replacement (PVR) with either a pulmonary homograft or Freestyle valve.

The authors primarily analyzed freedom from reintervention (surgical and/or catheter-based) and structural valve degeneration (peak gradient greater than 50 mm Hg and/or more that moderate pulmonary regurgitation). A total of 215 patients were included, 163 in the homograft group and 52 in the Freestyle group. The median follow-up was similar for both groups at approximately 8 years. Tetralogy of Fallot was the most common underlying diagnosis in both categories.

Compared to the Freestyle group, patients in the homograft group were younger (14.1 versus 10.2 years) and received conduits with a lower z-score (0.4 versus 1.5). Freedom from reintervention at 5, 10, and 15 years for the homograft group was 96%, 88%, and 81% and for the Freestyle group, 98%, 89%, and 31%. Freedom from structural valve degeneration at 5, 10, and 15 years for the homograft group was 92%, 87%, and 77% and for the Freestyle group, 96%, 80%, and 14%.

The two conduits exhibited overall similar performance up to 10 years after placement then appeared to diverge with more structural valve degeneration and reinterventions in the Freestyle group. A similar pattern was seen when propensity matching was used for 27 pairs of patients. The authors also observed that homografts fared better in an orthotopic position versus heterotopic position and that oversizing Freestyle valves did not affect later performance.

This retrospective, single-center study with mid-term follow-up offers additional insight into how well different conduits perform over time. There are several unanswered questions that could help to understand other implications of these findings:

  • How did the conduits fail (e.g., due to distal anastomotic stenosis)?
  • How were conduits selected, and was there any change in conduit preference over time?
  • When the conduits did fail, were patients more likely to be able to undergo transcatheter PVR with either conduit type?

As with most other studies of this topic, the present study is not comprehensive. Importantly, no bovine jugular venous conduits were used. At our center, we prefer to use bovine jugular venous conduits in patients less than 18 years of age and Freestyle valves in adult patients undergoing PVR. We agree with the authors in that stentless valves generally outperform stented valves in the pulmonary position.  Additionally, when it is necessary to use a pulmonary homograft, we prefer those that have been decellularized. In our experience, these have demonstrated improved durability possibly due to a reduced recipient immune response.

This study further demonstrates the considerable inter-institutional practice variation with conduit selection. The debate of the optimal conduit for right ventricular outflow tract remains undecided. Given the nuances of conduit characteristics and implant techniques, it may be difficult to absolutely compare results between institutions. Combining the experience of multiple centers may be necessary to capture a broader estimation of the long-term performance of the available conduits for right ventricular outflow tract reconstruction, however.

 

  1. Outcomes After Extracorporeal Cardiopulmonary Resuscitation of Pediatric In-Hospital Cardiac Arrest: A Report From the Get With the Guidelines-Resuscitation and the Extracorporeal Life Support Organization Registries.

Bembea MM, Ng DK, Rizkalla N, Rycus P, Lasa JJ, Dalton H, Topjian AA, Thiagarajan RR, Nadkarni VM, Hunt EA; American Heart Association’s Get With The Guidelines – Resuscitation Investigators.

Crit Care Med. 2019 Feb 8. doi: 10.1097/CCM.0000000000003622. [Epub ahead of print]

PMID: 30747771

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Select item 30753393

Take-Home Points: 

  • Extracorporeal membrane oxygenation (ECMO) in the setting of cardiopulmonary resuscitation is a necessary and useful adjunct salvage therapy, but is characterized by high peri-procedural and in-hospital mortality.
  • Several pre-existing patient conditions, procedural considerations, and ECMO-related complications predispose to an increased risk of mortality, some of which may be improved upon to afford better outcomes into the future. 

Commentary from Dr. Michael Ma (Stanford, CA), section editor of Congenital Heart Surgery Journal Watch:  Extracorporeal membrane oxygenation (ECMO) cardiopulmonary resuscitation (ECPR) is a critical salvage therapy for patients that fail return of spontaneous circulation (ROSC) despite more conventional Pediatric Advanced Life Support (PALS) algorithms. This study, designed as a multi-center, multi-registry, observational cohort, provides a high-level glimpse at the use of ECPR across the pediatric population (<18 years of age) spanning 32 hospitals over a 15 year period (2000-2014), totaling 593 cases. Registry data from Extracorporeal Life Support Organization (ELSO) and American Heart Association Get With the Guidelines-Resuscitation were linked and de-identified prior to analysis, which was performed using a variety of established statistical methods.

Of these 593 cases, median age 2.9mo, with 70% (414) infants, and 59% (351) were male. 59% (349) were cardiac surgical patients. Median duration of CPR prior to initiation of ECMO was 48 minutes (IQR 28-70 min), and median duration of ECMO support 3.9 days (IQR 2.0-6.7 days). Primary outcome (mortality) was characterized by 40.5% (240) death prior to ECMO decannulation, and 59.4% (352) death prior to hospital discharge. Increasing risk of mortality was associated with non-cardiac diagnosis, prearrest sepsis, respiratory insufficiency, renal insufficiency, longer duration from CPR activation to ECMO initiation, and adverse events reported while on ECMO. In multivariate regression (Figure 3, included below), a noncardiac diagnosis (adjusted OR 1.85 (95% CI 1.19-2.89)) and renal insufficiency (aOR 4.74 (95% CI 12.06-10.9)) were the strongest predictors of death. Each 5 minute incremental delay in the initiation of ECMO increased risk of death by 4% (aOR 1.04 (95% CI 1.01-1.07)). Adverse events on ECMO increased the risk of death, with neurologic and pulmonary complications being the most striking (aOR 2.76 and 2.55 respectively). Multiple adverse events compounded the risk of death further.

These findings corroborate existing, primarily single-center studies that examine ECPR in the pediatric population. The trends discovered are not altogether surprising; patients that require ECPR are at high risk of mortality, and those patients that have pre-existing conditions (i.e. non-cardiac diagnosis, renal insufficiency), peri-procedural difficulty (i.e. time to ECMO support), and post-procedural complications (i.e. adverse events on ECMO), are at the highest risk. The study does add substantially to our specific understanding and historical use of ECPR however, in that it aggregates two large and comprehensive datasets to provide an intimate and quantified understanding of how we, as a community, have performed with this therapy, and how we might go about improving that performance (i.e. patient selection, procedural efficiency, etc.) and counseling patients and families regarding expected prognosis.

 

  1. Use of mechanical valve prostheses in adults with tetralogy of Fallot.

Egbe AC, Miranda WR, Ammash NM, Said SM, Missula VR, Abdelsamid MF, Kothapalli S, Connolly HM.

Int J Cardiol. 2019 Feb 16. pii: S0167-5273(18)35800-5. doi: 10.1016/j.ijcard.2019.02.028. [Epub ahead of print]

PMID: 30803889

Similar articles

Select item 30777716

Take Home Points: 

  • Patients with Tetralogy of Fallot may need valve replacement during their lifetime, and there is limited data on the results of mechanical valve prostheses in these patients.
  • This retrospective, single-center study evaluated their experience with mechanical valve implantation in all valve positions – not just pulmonary. 

Commentary from Dr. Timothy Pirolli (Dallas), section editor of Congenital Heart Surgery Journal Watch:  Patients born with Tetralogy of Fallot typically undergo full repair within the first year of life (or within the first few years, from a historical perspective). Many of these patients have residual lesions, especially free pulmonary insufficiency due to transannular patch repair that may require surgery later in life. Currently, it is common practice for patients with free pulmonary regurgitation to undergo a redo sternotomy and implantation of a Bioprosthetic valve into the pulmonary position to preserve right ventricular function and decrease RV dilation. In some centers, surgeons may opt to use mechanical valves for high-risk patients or patients already on anticoagulation. Interestingly, this would lead the reader to believe that this study was about the results of implantation of mechanical valve in the pulmonary position at this center.

But, stop the presses!  Though the title seems to infer that is the topic of this study, the authors actually present their results of their cohort of mechanical valve implantation in ALL valve positions, not just the pulmonary position!  The authors sought to describe the incidence of mechanical valve related adverse events, reoperation and mortality in all TOF patients with mechanical valve prostheses.  The first question that an inquisitive reader might ask is: why are the authors concerned about the results of the mechanical valves in the other positions?  There is never a clear answer to this question.  However, by using all valve positions, it is clear that the authors can increased the number in this study cohort relative to just studying those with pulmonary valve implantations.

The study reviewed patients from the Mayo Adult Congenital Heart Disease database who were born with Tetralogy of Fallot and underwent mechanical valve implantation in all valve positions between 1990-2017. A total of 29 patients were identified who had a total of 44 valve implantations were identified, with 40 of the valves implanted at Mayo.  The median age was 44 years old ± 13 years and the interval between initial TOF repair and first mechanical valve implant was 37 ± 6 years. The valve types were 21 aortic, 6 mitral, 2 tricuspid and 11 pulmonary. Ten of the patients had more than one mechanical valve.  It’s fascinating that only 11 of the mechanical valves implanted were in the pulmonary position, given the TOF substrate of the patients. It also indicates that the institutional preference of the Mayo is to place bioprosthetic valves in the pulmonary position. All patients were on Coumadin postoperatively with goal INR ranges specific for the highest risk valve. Figure 1 shows the discharge, 1 year and 5 year average gradients across each of the valve types (excluding tricuspid valve) from the incomplete follow-up of the dataset. The graphs show no significant progression of gradient.

The MVRAE rate was 10 total events in 7 patients (24%). There were 4 endocarditis, one valve thrombosis and 5 major bleeds.  There were no strokes. Figure 2 shows the freedom from MVRAE events as well as the freedom from reoperation and survival Kaplan Meier curves. There was basically no discussion about the survival curve and re-operation rates, which is bizarre.

The authors admit the limitations of the study include a small sample size, retrospective nature, incomplete follow-up, selection bias and the usual limitations related to this type of study. For some reason, they claim the study is novel because it looks at the mechanical valve implantation into all 4 valve positions instead of just the pulmonary position in TOF patients.  This begs the question: what is the unique nature of the aortic, tricuspid and mitral positions in TOF patients as compared to non-TOF patients?  As far as I can surmise, the authors saw that the topic had never been published on and decided to add this study to the cumulative knowledge without a significant explanation of how it is useful.  I do not see how this study will alter the management of adult TOF patients who need valve surgery, as the same decision-making algorithms apply to these patients before this study was published as after it was.

Figures and Table

 

 

CHD Surgery Feb 2019

 

  1. Factors involved in initiation and regulation of complement lectin pathway influence postoperative outcome after pediatric cardiac surgery involving cardiopulmonary bypass.

Michalski M, Pągowska-Klimek I, Thiel S, Świerzko AS, Hansen AG, Jensenius JC, Cedzyński M.

Sci Rep. 2019 Feb 27;9(1):2930. doi: 10.1038/s41598-019-39742-w.

PMID: 30814659 Free PMC Article

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Select item 30814609

 

  1. Impact of timing on in-patient outcomes of complete repair of tetralogy of Fallot in infancy: an analysis of the United States National Inpatient 2005-2011 database.

Yang S, Wen L, Tao S, Gu J, Han J, Yao J, Wang J.

BMC Cardiovasc Disord. 2019 Feb 26;19(1):46. doi: 10.1186/s12872-019-0999-1.

PMID: 30808308 Free Article

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Select item 30808315

 

  1. Publisher Correction: Model-Based Therapy Planning Allows Prediction of Haemodynamic Outcome after Aortic Valve Replacement.

Kelm M, Goubergrits L, Bruening J, Yevtushenko P, Fernandes JF, Sündermann SH, Berger F, Falk V, Kuehne T, Nordmeyer S; CARDIOPROOF group.

Sci Rep. 2019 Feb 26;9(1):3327. doi: 10.1038/s41598-018-36022-x.

PMID: 30804387 Free PMC Article

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Select item 30806031

 

  1. Third Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report: Pre-Implant Characteristics and Outcomes.

Morales DLS, Rossano JW, VanderPluym C, Lorts A, Cantor R, St Louis J, Koeh D, Sutcliffe DL, Adachi I, Kirklin JK, Rosenthal DN, Blume ED; Pedimacs investigators.

Ann Thorac Surg. 2019 Feb 25. pii: S0003-4975(19)30230-9. doi: 10.1016/j.athoracsur.2019.01.038. [Epub ahead of print]

PMID: 30817920

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Select item 30823591

 

  1. Patient-specific three-dimensional printed heart models benefit preoperative planning for complex congenital heart disease.

Xu JJ, Luo YJ, Wang JH, Xu WZ, Shi Z, Fu JZ, Shu Q.

World J Pediatr. 2019 Feb 22. doi: 10.1007/s12519-019-00228-4. [Epub ahead of print]

PMID: 30796731

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Select item 30791694

 

  1. Creation of the Fontan circulation in sheep: a survival model†.

Van Puyvelde J, Rega F, Minami T, Claus P, Cools B, Gewillig M, Meyns B.

Interact Cardiovasc Thorac Surg. 2019 Feb 20. pii: ivz022. doi: 10.1093/icvts/ivz022. [Epub ahead of print]

PMID: 30789218

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Select item 30786108

 

  1. Gastrostomy tubes appear to be safe following pediatric orthotopic heart transplant.

Vavolizza RD, Grabski DF, Levin DE, Gander JW.

Pediatr Transplant. 2019 Feb 20:e13374. doi: 10.1111/petr.13374. [Epub ahead of print]

PMID: 30786108

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Select item 30782877

 

  1. Trends in Utilization, Mortality, Major Complications and Cost after Total Artificial Heart Implantation in the United States (2009-2015).

Briasoulis A, Akintoye E, Mohsen A, Inampudi C, Briasouli A, Asleh R, Alvarez P.

Hellenic J Cardiol. 2019 Feb 18. pii: S1109-9666(18)30522-0. doi: 10.1016/j.hjc.2019.02.002. [Epub ahead of print]

PMID: 30790715 Free Article

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Select item 30770620

 

  1. Use of mechanical valve prostheses in adults with tetralogy of Fallot.

Egbe AC, Miranda WR, Ammash NM, Said SM, Missula VR, Abdelsamid MF, Kothapalli S, Connolly HM.

Int J Cardiol. 2019 Feb 16. pii: S0167-5273(18)35800-5. doi: 10.1016/j.ijcard.2019.02.028. [Epub ahead of print]

PMID: 30803889

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Select item 30777716

 

  1. [Abdominal surgery in premature infants with patent ductus arteriosus].

Hernández Díaz C, Ruiz Hierro C, Ortega Escudero M, Montero García J, Galvañ Felix Y, Martínez Díaz S, Suárez Fernández J.

An Pediatr (Barc). 2019 Feb 15. pii: S1695-4033(19)30018-9. doi: 10.1016/j.anpedi.2018.12.014. [Epub ahead of print] Spanish.

PMID: 30777716 Free Article

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Select item 30537348

 

  1. Predictors of operability in children with severe pulmonary hypertension associated with congenital heart disease.

Xi SB, Wang SS, Qian MY, Xie YM, Li JJ, Zhang ZW.

Chin Med J (Engl). 2019 Feb 15. doi: 10.1097/CM9.0000000000000145. [Epub ahead of print]

PMID: 30789367

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Select item 30590978

 

  1. Aggregation of Child Cardiac Progenitor Cells Into Spheres Activates Notch Signaling and Improves Treatment of Right Ventricular Heart Failure.

Trac D, Maxwell JT, Brown ME, Xu C, Davis ME.

Circ Res. 2019 Feb 15;124(4):526-538. doi: 10.1161/CIRCRESAHA.118.313845.

PMID: 30590978

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Select item 30582441

 

  1. Current Challenges and Emergent Technologies for Manufacturing Artificial Right Ventricle to Pulmonary Artery (RV-PA) Cardiac Conduits.

Manavitehrani I, Ebrahimi P, Yang I, Daly S, Schindeler A, Saxena A, Little DG, Fletcher DF, Dehghani F, Winlaw DS.

Cardiovasc Eng Technol. 2019 Feb 14. doi: 10.1007/s13239-019-00406-5. [Epub ahead of print] Review.

PMID: 30767113

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Select item 30799229

 

  1. Change in N-terminal pro B-type natriuretic peptide levels and clinical outcomes in children undergoing congenital heart surgery.

Gupta RK, Zheng H, Cui Y, Qu J, Li L, Liang H, Li K, Chen X, Xia H.

Int J Cardiol. 2019 Feb 14. pii: S0167-5273(18)35403-2. doi: 10.1016/j.ijcard.2019.02.025. [Epub ahead of print]

PMID: 30833104

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Select item 30808604

 

  1. Pediatric ventricular assist devices: Bridge to a new era of peri-operative care.

Navaratnam M, Maeda K, Hollander SA.

Paediatr Anaesth. 2019 Feb 13. doi: 10.1111/pan.13609. [Epub ahead of print]

PMID: 30758099

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Select item 30819513

 

  1. Postoperative Acute Kidney Injury in Young Adults with Congenital Heart Disease.

Fuhrman DY, Nguyen LG, Sanchez-de-Toledo J, Priyanka P, Kellum JA.

Ann Thorac Surg. 2019 Feb 11. pii: S0003-4975(19)30194-8. doi: 10.1016/j.athoracsur.2019.01.017. [Epub ahead of print]

PMID: 30763561

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Select item 30805324

 

  1. 3D-Printed Models for Surgical Planning in Complex Congenital Heart Diseases: A Systematic Review.

Batteux C, Haidar MA, Bonnet D.

Front Pediatr. 2019 Feb 11;7:23. doi: 10.3389/fped.2019.00023. eCollection 2019.

PMID: 30805324 Free PMC Article

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  1. Double-lung versus heart-lung transplantation for precapillary pulmonary arterial hypertension: a 24-year single-center retrospective study.

Brouckaert J, Verleden SE, Verbelen T, Coosemans W, Decaluwé H, De Leyn P, Depypere L, Nafteux P, Van Veer H, Meyns B, Rega F, Van De Velde M, Poortmans G, Rex S, Neyrinck A, Van den Berghe G, Vlasselaers D, Van Cleemput J, Budts W, Vos R, Quarck R, Belge C, Delcroix M, Verleden GM, Van Raemdonck D.

Transpl Int. 2019 Feb 8. doi: 10.1111/tri.13409. [Epub ahead of print]

PMID: 30735591

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  1. Homografts versus stentless bioprosthetic valves in the pulmonary position: a multicentre propensity-matched comparison in patients younger than 20 years.

Marathe SP, Bell D, Betts K, Sayed S, Dunne B, Ward C, Whight C, Jalali H, Venugopal P, Andrews D, Alphonso N.

Eur J Cardiothorac Surg. 2019 Feb 7. doi: 10.1093/ejcts/ezz021. [Epub ahead of print]

PMID: 30753373

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  1. Characteristics and Outcomes of Heart Transplantation in DiGeorge Syndrome.

Woolman P, Bearl DW, Soslow JH, Dodd DA, Thurm C, Hall M, Feingold B, Godown J.

Pediatr Cardiol. 2019 Feb 7. doi: 10.1007/s00246-019-02063-w. [Epub ahead of print]

PMID: 30729260

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  1. Quality of life among patients with congenital heart disease after valve replacement.

Pragt H, Pieper PG, van Slooten YJ, Freling HG, van Dijk APJ, Sieswerda GTJ, Bouma BJ, Post MC, Jongbloed MRM, Willems TP, Ebels T, van Melle JP.

Semin Thorac Cardiovasc Surg. 2019 Feb 4. pii: S1043-0679(19)30021-8. doi: 10.1053/j.semtcvs.2019.02.002. [Epub ahead of print]

PMID: 30731194

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  1. Recent achievements and future developments in neonatal cardiopulmonary bypass.

Bojan M.

Paediatr Anaesth. 2019 Feb 3. doi: 10.1111/pan.13597. [Epub ahead of print]

PMID: 30714261

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  1. Review findings included diminished coronary flow reserve after surgery in children with congenital heart disease and inflammation.

Pesonen E, Liuba P, Aburawi EH.

Acta Paediatr. 2019 Feb;108(2):218-223. doi: 10.1111/apa.14613. Epub 2018 Nov 22. Review.

PMID: 30312493

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  1. In Vitro Examination of the VentriFlo True Pulse Pump for Failing Fontan Support.

Trusty PM, Tree M, Vincent D, Naber JP, Maher K, Yoganathan AP, Deshpande SR.

Artif Organs. 2019 Feb;43(2):181-188. doi: 10.1111/aor.13301. Epub 2018 Nov 4.

PMID: 30393925

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  1. Vacuum-Assisted Closure for Mediastinitis in Pediatric Cardiac Surgery: A Single-Center Experience.

Onan IS, Yildiz O, Tüzün B, Timur B, Haydin S.

Artif Organs. 2019 Feb;43(2):119-124. doi: 10.1111/aor.13321. Epub 2018 Oct 3.

PMID: 30281163

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  1. Mechanical Circulatory Support of the Right Ventricle for Adult and Pediatric Patients With Heart Failure.

Chopski SG, Murad NM, Fox CS, Stevens RM, Throckmorton AL.

ASAIO J. 2019 Feb;65(2):106-116. doi: 10.1097/MAT.0000000000000815.

PMID: 29757759

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  1. Comparison of the Efficacy of Ultrasound-Guided Serratus Anterior Plane Block, Pectoral Nerves II Block, and Intercostal Nerve Block for the Management of Postoperative Thoracotomy Pain After Pediatric Cardiac Surgery.

Kaushal B, Chauhan S, Saini K, Bhoi D, Bisoi AK, Sangdup T, Khan MA.

J Cardiothorac Vasc Anesth. 2019 Feb;33(2):418-425. doi: 10.1053/j.jvca.2018.08.209. Epub 2018 Aug 31.

PMID: 30293833

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  1. Creation of an empiric tool to predict ECMO deployment in pediatric respiratory or cardiac failure.

Gupta P, Gossett JM, Kofos D, Rettiganti M.

J Crit Care. 2019 Feb;49:21-26. doi: 10.1016/j.jcrc.2018.10.007. Epub 2018 Oct 12.

PMID: 30342418

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  1. Not all neonates with oesophageal atresia and tracheoesophageal fistula are a surgical emergency.

Thompson A, Thakkar H, Khan H, Yardley IE.

J Pediatr Surg. 2019 Feb;54(2):244-246. doi: 10.1016/j.jpedsurg.2018.10.074. Epub 2018 Nov 7.

PMID: 30518493

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  1. Increased mortality, morbidities, and costs after heart transplantation in heterotaxy syndrome and other complex situs arrangements.

Duong SQ, Godown J, Soslow JH, Thurm C, Hall M, Sainathan S, Morell VO, Dodd DA, Feingold B.

J Thorac Cardiovasc Surg. 2019 Feb;157(2):730-740.e11. doi: 10.1016/j.jtcvs.2018.11.022. Epub 2018 Nov 16.

PMID: 30669235

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  1. Staged Repair after Hybrid Palliation for Interrupted Aortic Arch with Systemic Outflow Tract Obstruction.

Lee J, Kim YH, Lee C.

Korean J Thorac Cardiovasc Surg. 2019 Feb;52(1):32-35. doi: 10.5090/kjtcs.2019.52.1.32. Epub 2019 Feb 5.

PMID: 30834215 Free Article

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  1. Did Malnutrition Affect Post-Operative Somatic Growth in Pediatric Patients Undergoing Surgical Procedures for Congenital Heart Disease?

Fitria L, Caesa P, Joe J, Marwali EM.

Pediatr Cardiol. 2019 Feb;40(2):431-436. doi: 10.1007/s00246-018-2022-5. Epub 2018 Nov 29.

PMID: 30498851

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  1. The Relationship Between Pre-operative Left Ventricular Longitudinal Strain and Post-operative Length of Stay in Patients Undergoing Arterial Switch Operation Is Age Dependent.

Pletzer SA, Atz AM, Chowdhury SM.

Pediatr Cardiol. 2019 Feb;40(2):366-373. doi: 10.1007/s00246-018-2018-1. Epub 2018 Nov 9.

PMID: 30413855

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  1. The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome?

Cleveland D, Adam Banks C, Hara H, Carlo WF, Mauchley DC, Cooper DKC.

Pediatr Cardiol. 2019 Feb;40(2):437-444. doi: 10.1007/s00246-018-1998-1. Epub 2018 Oct 9.

PMID: 30302505

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  1. Early Peritoneal Dialysis and Major Adverse Events After Pediatric Cardiac Surgery: A Propensity Score Analysis.

Namachivayam SP, Butt W, Millar J, Konstantinov IE, Nguyen C, d’Udekem Y.

Pediatr Crit Care Med. 2019 Feb;20(2):158-165. doi: 10.1097/PCC.0000000000001793.

PMID: 30399019

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  1. Noncardiac surgery in the congenital heart patient.

Pilkington M, Egan JC.

Semin Pediatr Surg. 2019 Feb;28(1):11-17. doi: 10.1053/j.sempedsurg.2019.01.003. Epub 2019 Jan 18.

PMID: 30824128

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  1. Third Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report: Pre-Implant Characteristics and Outcomes.

Morales DLS, Rossano JW, VanderPluym C, Lorts A, Cantor R, St Louis J, Koeh D, Sutcliffe DL, Adachi I, Kirklin JK, Rosenthal DN, Blume ED; Pedimacs investigators.

Ann Thorac Surg. 2019 Feb 25. pii: S0003-4975(19)30230-9. doi: 10.1016/j.athoracsur.2019.01.038. [Epub ahead of print]

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  1. Extracorporeal membrane oxygenation in a low-weight infant after cardiac surgery.

Fuchigami T, Nagata N, Nishioka M, Akashige T, Fujiwara N, Nakayashiro M.

Asian Cardiovasc Thorac Ann. 2019 Feb 24:218492319833268. doi: 10.1177/0218492319833268. [Epub ahead of print]

PMID: 30798610

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  1. Combined Heart and Kidney Transplantation: Clinical Experience in 100 Consecutive Patients.

Awad MA, Czer LSC, Emerson D, Jordan S, De Robertis MA, Mirocha J, Kransdorf E, Chang DH, Patel J, Kittleson M, Ramzy D, Chung JS, Cohen JL, Esmailian F, Trento A, Kobashigawa JA.

J Am Heart Assoc. 2019 Feb 19;8(4):e010570. doi: 10.1161/JAHA.118.010570.

PMID: 30741603 Free Article

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  1. Does Coronary Reimplantation After Neoaortic Reconstruction Increase Aortic Regurgitation?

Choi KH, Sung SC, Kim H, Lee HD, Kim G, Ko H, Byun JH, Lee YS.

Pediatr Cardiol. 2019 Feb 19. doi: 10.1007/s00246-019-02075-6. [Epub ahead of print]

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  1. A Recipient Risk Prediction Tool for Short Term Mortality after Pediatric Heart Transplantation.

Choudhry S, Wang Y, Denfield SW, Cabrera AG, Price JF, Tunuguntla HP, Dharnidharka VR, Canter CE, Dreyer WJ.

Transplantation. 2019 Feb 19. doi: 10.1097/TP.0000000000002679. [Epub ahead of print]

PMID: 30801538

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  1. Pediatric ventricular assist devices: Bridge to a new era of peri-operative care.

Navaratnam M, Maeda K, Hollander SA.

Paediatr Anaesth. 2019 Feb 13. doi: 10.1111/pan.13609. [Epub ahead of print]

PMID: 30758099

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  1. Variable Treatment Approaches for Extracorporeal Membrane Oxygenation Complications in Neonates: A Case Series.

VanLoozen D, Burch Z, Shivaram P, Amin Z.

Pediatr Cardiol. 2019 Feb 13. doi: 10.1007/s00246-019-02070-x. [Epub ahead of print]

PMID: 30758519

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  1. First experience with Tolvaptan for the treatment of neonates and infants with capillary leak syndrome after cardiac surgery.

Kerling A, Toka O, Rüffer A, Müller H, Habash S, Weiss C, Dittrich S, Moosmann J.

BMC Pediatr. 2019 Feb 12;19(1):57. doi: 10.1186/s12887-019-1418-6.

PMID: 30755181 Free PMC Article

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  1. Postoperative Acute Kidney Injury in Young Adults with Congenital Heart Disease.

Fuhrman DY, Nguyen LG, Sanchez-de-Toledo J, Priyanka P, Kellum JA.

Ann Thorac Surg. 2019 Feb 11. pii: S0003-4975(19)30194-8. doi: 10.1016/j.athoracsur.2019.01.017. [Epub ahead of print]

PMID: 30763561

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  1. Tetralogy of Fallot and abnormal coronary artery: use of a prosthetic conduit is outdated.

Pontailler M, Bernard C, Gaudin R, Moreau de Bellaing A, Mostefa Kara M, Haydar A, Barbanti C, Bonnet D, Vouhé P, Raisky O.

Eur J Cardiothorac Surg. 2019 Feb 11. doi: 10.1093/ejcts/ezz030. [Epub ahead of print]

PMID: 30753614

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  1. 3D-Printed Models for Surgical Planning in Complex Congenital Heart Diseases: A Systematic Review.

Batteux C, Haidar MA, Bonnet D.

Front Pediatr. 2019 Feb 11;7:23. doi: 10.3389/fped.2019.00023. eCollection 2019.

PMID: 30805324 Free PMC Article

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  1. Combined Surgical and Endoscopic Approach for Ring-Sling Complex.

Porcedda G, Brambilla A, Favilli S, Murzi B, Mirabile L, Baggi R, Arcieri L.

Thorac Cardiovasc Surg. 2019 Feb 11. doi: 10.1055/s-0039-1678670. [Epub ahead of print]

PMID: 30743276

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  1. Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study.

Padalino MA, Franchetti N, Sarris GE, Hazekamp M, Carrel T, Frigiola A, Horer J, Roussin R, Cleuziou J, Meyns B, Fragata J, Telles H, Polimenakos AC, Francois K, Veshti A, Salminen J, Rocafort AG, Nosal M, Vedovelli L, Protopapas E, Tumbarello R, Merola A, Pegoraro C, Motta R, Boccuzzo G, Sojak V, Rito ML, Caldaroni F, Corrado D, Basso C, Stellin G.

Int J Cardiol. 2019 Feb 10. pii: S0167-5273(18)37161-4. doi: 10.1016/j.ijcard.2019.02.007. [Epub ahead of print]

PMID: 30772012 Free Article

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  1. Readmission Following Pediatric Cardiothoracic Surgery: An analysis of the Society of Thoracic Surgeons Database.

Kogon BE, Oster ME, Wallace A, Chiswell K, Hill KD, Cox ML, Jacobs JP, Pasquali S, Karamlou T, Jacobs ML.

Ann Thorac Surg. 2019 Feb 8. pii: S0003-4975(19)30185-7. doi: 10.1016/j.athoracsur.2019.01.009. [Epub ahead of print]

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  1. The ELSO Maastricht Treaty for ECLS Nomenclature: abbreviations for cannulation configuration in extracorporeal life support – a position paper of the Extracorporeal Life Support Organization.

Broman LM, Taccone FS, Lorusso R, Malfertheiner MV, Pappalardo F, Di Nardo M, Belliato M, Bembea MM, Barbaro RP, Diaz R, Grazioli L, Pellegrino V, Mendonca MH, Brodie D, Fan E, Bartlett RH, McMullan MM, Conrad SA.

Crit Care. 2019 Feb 8;23(1):36. doi: 10.1186/s13054-019-2334-8.

PMID: 30736845 Free PMC Article

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  1. Outcomes After Extracorporeal Cardiopulmonary Resuscitation of Pediatric In-Hospital Cardiac Arrest: A Report From the Get With the Guidelines-Resuscitation and the Extracorporeal Life Support Organization Registries.

Bembea MM, Ng DK, Rizkalla N, Rycus P, Lasa JJ, Dalton H, Topjian AA, Thiagarajan RR, Nadkarni VM, Hunt EA; American Heart Association’s Get With The Guidelines – Resuscitation Investigators.

Crit Care Med. 2019 Feb 8. doi: 10.1097/CCM.0000000000003622. [Epub ahead of print]

PMID: 30747771

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  1. Biventricular repair after the hybrid Norwood procedure.

Sojak V, Bokenkamp R, Kuipers I, Schneider A, Hazekamp M.

Eur J Cardiothorac Surg. 2019 Feb 8. doi: 10.1093/ejcts/ezz028. [Epub ahead of print]

PMID: 30753393

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  1. Comparison of 10-year graft failure rates after induction with basiliximab or anti-thymocyte globulin in pediatric heart transplant recipients-The influence of race.

Carlo WF, Bryant R 3rd, Zafar F.

Pediatr Transplant. 2019 Feb 8:e13366. doi: 10.1111/petr.13366. [Epub ahead of print]

PMID: 30735604

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  1. Compassionate deactivation of ventricular assist devices in children: A survey of pediatric ventricular assist device clinicians’ perspectives and practices.

Kaufman BD, Hollander SA, Zhang Y, Chen S, Bernstein D, Rosenthal DN, Almond CS, Murray JM, Burgart AM, Cohen HJ, Kirkpatrick JN, Blume ED.

Pediatr Transplant. 2019 Feb 7:e13359. doi: 10.1111/petr.13359. [Epub ahead of print]

PMID: 30734422

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  1. Reconstructive surgery for Ebstein anomaly: three decades of experience.

Veen KM, Mokhles MM, Roos-Hesselink JW, Rebel BR, Takkenberg JJM, Bogers AJJC.

Eur J Cardiothorac Surg. 2019 Feb 5. doi: 10.1093/ejcts/ezz022. [Epub ahead of print]

PMID: 30726890

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  1. Hospital Distribution and Patient Travel Patterns for Congenital Cardiac Surgery in the United States.

Welke KF, Pasquali SK, Lin P, Backer CL, Overman DM, Romano JC, Jacobs JP, Karamlou T.

Ann Thorac Surg. 2019 Feb;107(2):574-581. doi: 10.1016/j.athoracsur.2018.07.047. Epub 2018 Sep 21.

PMID: 30248321

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Select item 30118715

 

  1. Giant Aneurysm of the Ascending Aorta Requiring Emergency Repair in a Newborn Baby.

Tireli E, Polat TB, Oztas DM, Mamur Y, Omeroglu RE, Ugurlucan M.

Ann Thorac Surg. 2019 Feb;107(2):e107-e109. doi: 10.1016/j.athoracsur.2018.06.067. Epub 2018 Aug 14.

PMID: 30118715

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  1. Successful Heart Transplantation in Two Infants With Dextrocardia-Heterotaxy Syndrome.

Boston U, Kumar TS, Shah J, Street T, Towbin J, Knott-Craig CJ.

Ann Thorac Surg. 2019 Feb;107(2):e111-e114. doi: 10.1016/j.athoracsur.2018.06.046. Epub 2018 Aug 3.

PMID: 30081023

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Select item 29970581

 

  1. Functional outcome in contemporary children and young adults with tetralogy of Fallot after repair.

Hock J, Häcker AL, Reiner B, Oberhoffer R, Hager A, Ewert P, Müller J.

Arch Dis Child. 2019 Feb;104(2):129-133. doi: 10.1136/archdischild-2017-314733. Epub 2018 Jul 3.

PMID: 29970581

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  1. Child presenting with breathlessness 1 month after cardiac surgery.

Gesuete V, Salis S, Gortani G, Barbi E.

Arch Dis Child Educ Pract Ed. 2019 Feb 1. pii: edpract-2018-316156. doi: 10.1136/archdischild-2018-316156. [Epub ahead of print]

PMID: 30709940

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  1. Monitoring Platelet Function in Children With Ventricular Assist Devices: The Devil Is in the Details.

Massicotte MP, Kreuziger LB.

ASAIO J. 2019 Feb;65(2):104-105. doi: 10.1097/MAT.0000000000000948. No abstract available.

PMID: 30640186

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  1. Iatrogenic diaphragmatic hernia in an infant following cardiac surgery: the culprit in a case of unresolved respiratory distress: Case report and review of the literature.

Heinrichs EN, Miller MS.

Cardiol Young. 2019 Feb;29(2):238-240. doi: 10.1017/S1047951118001968.

PMID: 30785382

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  1. Edwards Inspiris Resilia® valve for mitral replacement in an infant after mechanical valve failure.

Jaworski R, Kansy A, Birbach M, Brodzikowska-Pytel A, Kowalczyk-Domagala M, Brzezinska-Rajszys G, Maruszewski B.

Cardiol Young. 2019 Feb;29(2):219-221. doi: 10.1017/S1047951118001816. Epub 2018 Dec 3.

PMID: 30501652

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  1. Increased mortality, morbidities, and costs after heart transplantation in heterotaxy syndrome and other complex situs arrangements.

Duong SQ, Godown J, Soslow JH, Thurm C, Hall M, Sainathan S, Morell VO, Dodd DA, Feingold B.

J Thorac Cardiovasc Surg. 2019 Feb;157(2):730-740.e11. doi: 10.1016/j.jtcvs.2018.11.022. Epub 2018 Nov 16.

PMID: 30669235

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Select item 30669228

 

  1. Intervention for arch obstruction after the Norwood procedure: Prevalence, associated factors, and practice variability.

Devlin PJ, McCrindle BW, Kirklin JK, Blackstone EH, DeCampli WM, Caldarone CA, Dodge-Khatami A, Eghtesady P, Meza JM, Gruber PJ, Guleserian KJ, Alsoufi B, Lambert LM, O’Brien JE Jr, Austin EH 3rd, Jacobs JP, Karamlou T.

J Thorac Cardiovasc Surg. 2019 Feb;157(2):684-695.e8. doi: 10.1016/j.jtcvs.2018.09.130. Epub 2018 Nov 22.

PMID: 30669228

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Select item 30471711

 

  1. Fifty-Five Years Follow-Up of 111 Adult Survivors After Biventricular Repair of PAIVS and PS.

Shi JZ, Chow PC, Li W, Kwok SY, Wong WH, Cheung YF.

Pediatr Cardiol. 2019 Feb;40(2):374-383. doi: 10.1007/s00246-018-2041-2. Epub 2018 Dec 11.

PMID: 30539241

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  1. Center Variation in Hospital Costs for Pediatric Heart Transplantation: The Relationship Between Cost and Outcomes.

Godown J, Thurm C, Hall M, Dodd DA, Feingold B, Soslow JH, Mettler BA, Smith AH, Bearl DW, Schumacher KR.

Pediatr Cardiol. 2019 Feb;40(2):357-365. doi: 10.1007/s00246-018-2011-8. Epub 2018 Oct 20.

PMID: 30343331

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Select item 30334087

 

  1. Healthy hearts in pediatric heart transplant patients with an exercise and diet intervention via live video conferencing-Design and rationale.

Chen AC, Rosenthal DN, Couch SC, Berry S, Stauffer KJ, Brabender J, McDonald N, Lee D, Barkoff L, Nourse SE, Kazmucha J, Wang CJ, Olson I, Selamet Tierney ES.

Pediatr Transplant. 2019 Feb;23(1):e13316. doi: 10.1111/petr.13316. Epub 2018 Nov 4.

PMID: 30393915

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Select item 30707444

 

  1. Repair of Scimitar syndrome using an extracardiac conduit in pediatric patients: Report of two patients.

Ak K, Cevik BS, Arsan S, Akalin F, Cobanoglu A.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):49-52. doi: 10.4103/apc.APC_92_18.

PMID: 30745770 Free PMC Article

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  1. Outcome of pediatric cardiac surgery and predictors of major complication in a developing country.

Murni IK, Djer MM, Yanuarso PB, Putra ST, Advani N, Rachmat J, Perdana A, Sukardi R.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):38-44. doi: 10.4103/apc.APC_146_17.

PMID: 30745768 Free PMC Article

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  1. Short-term clinical and echocardiographic outcomes after use of polytetrafluoroethylene bicuspid pulmonary valve during the repair of tetralogy of Fallot.

Wankhade PR, Aggarwal N, Joshi RK, Agarwal M, Joshi R, Mehta A, Kar S.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):25-31. doi: 10.4103/apc.APC_51_18.

PMID: 30745766 Free PMC Article

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  1. Pediatric cardiac surgery in low- and middle-income countries – Fighting the odds.

Iyer KS.

Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):1-2. doi: 10.4103/apc.APC_192_18. No abstract available.

PMID: 30745762 Free PMC Article

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Fetal Cardiology Featured Articles

Fetal Cardiology

 

Fetal Cardiology and genetics Feb 2019

 

  1. Exploration of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension using rat model.

Chen X, Zhou W, Hu Q, Huang L.

Congenit Heart Dis. 2019 Feb 27. doi: 10.1111/chd.12733. [Epub ahead of print]

PMID: 30811836

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  1. Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study.

Lord J, McMullan DJ, Eberhardt RY, Rinck G, Hamilton SJ, Quinlan-Jones E, Prigmore E, Keelagher R, Best SK, Carey GK, Mellis R, Robart S, Berry IR, Chandler KE, Cilliers D, Cresswell L, Edwards SL, Gardiner C, Henderson A, Holden ST, Homfray T, Lester T, Lewis RA, Newbury-Ecob R, Prescott K, Quarrell OW, Ramsden SC, Roberts E, Tapon D, Tooley MJ, Vasudevan PC, Weber AP, Wellesley DG, Westwood P, White H, Parker M, Williams D, Jenkins L, Scott RH, Kilby MD, Chitty LS, Hurles ME, Maher ER; Prenatal Assessment of Genomes and Exomes Consortium.

Lancet. 2019 Feb 23;393(10173):747-757. doi: 10.1016/S0140-6736(18)31940-8. Epub 2019 Jan 31.

PMID: 30712880 Free PMC Article

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  1. An integrated in utero MR method for assessing structural brain abnormalities and measuring intracranial volumes in fetuses with congenital heart disease: results of a prospective case-control feasibility study.

Griffiths PD, Mousa HA, Finney C, Mooney C, Mandefield L, Chico TJA, Jarvis D.

Neuroradiology. 2019 Feb 22. doi: 10.1007/s00234-019-02184-2. [Epub ahead of print]

PMID: 30796469

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  1. VGLL4 plays a critical role in heart valve development and homeostasis.

Yu W, Ma X, Xu J, Heumüller AW, Fei Z, Feng X, Wang X, Liu K, Li J, Cui G, Peng G, Ji H, Li J, Jing N, Song H, Lin Z, Zhao Y, Wang Z, Zhou B, Zhang L.

PLoS Genet. 2019 Feb 21;15(2):e1007977. doi: 10.1371/journal.pgen.1007977. eCollection 2019 Feb.

PMID: 30789911 Free Article

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  1. Gene-environment interaction impacts on heart development and embryo survival.

Moreau JLM, Kesteven S, Martin EMMA, Lau KS, Yam MX, O’Reilly VC, Del Monte-Nieto G, Baldini A, Feneley MP, Moon AM, Harvey RP, Sparrow DB, Chapman G, Dunwoodie SL.

Development. 2019 Feb 20;146(4). pii: dev172957. doi: 10.1242/dev.172957.

PMID: 30787001

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Select item 30321660

 

  1. The correlation of TGFβ1 gene polymorphisms with congenital heart disease susceptibility.

Shi Y, Zhang J, Xu W, Yi J, Li Y, Chen Y.

Gene. 2019 Feb 20;686:160-163. doi: 10.1016/j.gene.2018.10.034. Epub 2018 Oct 12.

PMID: 30321660

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Select item 30789218

 

  1. Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot.

Page DJ, Miossec MJ, Williams SG, Monaghan RM, Fotiou E, Cordell HJ, Sutcliffe L, Topf A, Bourgey M, Bourque G, Eveleigh R, Dunwoodie SL, Winlaw DS, Bhattacharya S, Breckpot J, Devriendt K, Gewillig M, Brook JD, Setchfield KJ, Bu’Lock FA, O’Sullivan J, Stuart G, Bezzina CR, Mulder BJM, Postma AV, Bentham JR, Baron M, Bhaskar SS, Black GC, Newman WG, Hentges KE, Lathrop GM, Santibanez-Koref M, Keavney BD.

Circ Res. 2019 Feb 15;124(4):553-563. doi: 10.1161/CIRCRESAHA.118.313250.

PMID: 30582441

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Select item 30770573

 

  1. Dioxin and AHR impairs mesoderm gene expression and cardiac differentiation in human embryonic stem cells.

Fu H, Wang L, Wang J, Bennett BD, Li JL, Zhao B, Hu G.

Sci Total Environ. 2019 Feb 15;651(Pt 1):1038-1046. doi: 10.1016/j.scitotenv.2018.09.247. Epub 2018 Sep 20.

PMID: 30266049

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Select item 30767113

 

  1. Endocardially Derived Macrophages Are Essential for Valvular Remodeling.

Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A.

Dev Cell. 2019 Feb 14. pii: S1534-5807(19)30049-8. doi: 10.1016/j.devcel.2019.01.021. [Epub ahead of print]

PMID: 30799229

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Select item 30833104

 

  1. Novel mutations of AXIN2 identified in a Chinese Congenital Heart Disease Cohort.

Zhu MJ, Ma XY, Ding PC, Tang HF, Peng R, Lu L, Li PQ, Qiao B, Yang XY, Zheng YF, Wang HY, Gao YQ, Chen FS.

J Hum Genet. 2019 Feb 13. doi: 10.1038/s10038-019-0572-x. [Epub ahead of print]

PMID: 30760879

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Select item 30758718

 

  1. Using speckle tracking echocardiography to assess fetal myocardial deformation: are we there yet?

Day TG, Charakida M, Simpson JM.

Ultrasound Obstet Gynecol. 2019 Feb 10. doi: 10.1002/uog.20233. [Epub ahead of print]

PMID: 30740804

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Select item 30739593

 

  1. Identifying pathogenic variants in the Follistatin-like 1 gene (FSTL1) in patients with skeletal and atrioventricular valve disorders.

Prakash S, Mattiotti A, Sylva M, Mulder BJM, Postma AV, van den Hoff MJB.

Mol Genet Genomic Med. 2019 Feb 5:e567. doi: 10.1002/mgg3.567. [Epub ahead of print]

PMID: 30722102 Free Article

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Select item 30722724

 

  1. Prognosis of severe congenital heart diseases: Do we overestimate the impact of prenatal diagnosis?

Vincenti M, Guillaumont S, Clarivet B, Macioce V, Mura T, Boulot P, Cambonie G, Amedro P.

Arch Cardiovasc Dis. 2019 Feb 2. pii: S1875-2136(19)30020-8. doi: 10.1016/j.acvd.2018.11.013. [Epub ahead of print]

PMID: 30722979

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Select item 30747003

 

  1. Proteomic-based approaches to cardiac development and disease.

Dorr KM, Conlon FL.

Curr Opin Chem Biol. 2019 Feb;48:150-157. doi: 10.1016/j.cbpa.2019.01.001. Epub 2019 Jan 31. Review.

PMID: 30711722

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Select item 30548532

 

  1. Combinatorial Utilization of Murine Embryonic Stem Cells and In Vivo Models to Study Human Congenital Heart Disease.

Zakariyah A, Rajgara R, Shelton M, Blais A, Skerjanc IS, Burgon PG.

Curr Protoc Stem Cell Biol. 2019 Feb;48(1):e75. doi: 10.1002/cpsc.75. Epub 2018 Dec 12.

PMID: 30548532

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Select item 30444277

 

  1. pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish.

Bhakta M, Padanad MS, Harris JP, Lubczyk C, Amatruda JF, Munshi NV.

Dev Dyn. 2019 Feb;248(2):173-188. doi: 10.1002/dvdy.2. Epub 2018 Dec 10.

PMID: 30444277

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Select item 30685882

 

  1. Prenatal diagnosis of caudal regression with heterotaxy syndrome: “A mermaid with a broken heart”.

Zhang Y, Sun C, Jiang C, Zhao W, Wang W, Cao Q, Ge S.

Echocardiography. 2019 Feb;36(2):415-418. doi: 10.1111/echo.14250. Epub 2019 Jan 27.

PMID: 30685882

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Select item 30628131

 

  1. Akt3 is a target of miR-29c-3p and serves an important function in the pathogenesis of congenital heart disease.

Chen T, Li SJ, Chen B, Huang Q, Kong XY, Shen C, Gu HT, Wang XW.

Int J Mol Med. 2019 Feb;43(2):980-992. doi: 10.3892/ijmm.2018.4008. Epub 2018 Nov 30.

PMID: 30535467

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Select item 29855859

 

  1. Copy number variations in the GATA4, NKX2-5, TBX5, BMP4 CRELD1, and 22q11.2 gene regions in Chinese children with sporadic congenital heart disease.

Li Z, Huang J, Liang B, Zeng D, Luo S, Yan T, Liao F, Huang J, Li J, Cai R, Deng X, Tang N.

J Clin Lab Anal. 2019 Feb;33(2):e22660. doi: 10.1002/jcla.22660. Epub 2018 Sep 17.

PMID: 30221396

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Select item 30342418

 

  1. Clinical application of chromosomal microarray analysis for the diagnosis of Williams-Beuren syndrome in Chinese Han patients.

Xia Y, Huang S, Wu Y, Yang Y, Chen S, Li P, Zhuang J.

Mol Genet Genomic Med. 2019 Feb;7(2):e00517. doi: 10.1002/mgg3.517. Epub 2018 Dec 18.

PMID: 30565396 Free Article

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Select item 30525309

 

  1. A regulatory variant in TBX2 promoter is related to the decreased susceptibility of congenital heart disease in the Han Chinese population.

Zhang RR, Cai K, Liu L, Yang Q, Zhang P, Gui YH, Wang F.

Mol Genet Genomic Med. 2019 Feb;7(2):e00530. doi: 10.1002/mgg3.530. Epub 2018 Dec 7.

PMID: 30525309 Free Article

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Select item 30482476

 

  1. Evaluation of the post-LA space index in the normal fetus.

Kawazu Y, Inamura N, Kayatani F, Taniguchi T.

Prenat Diagn. 2019 Feb;39(3):195-199. doi: 10.1002/pd.5409. Epub 2019 Jan 10.

PMID: 30615216

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Select item 30673498

 

  1. Functional Morphology of the Cardiac Jelly in the Tubular Heart of Vertebrate Embryos.

Männer J, Männer TM.

J Cardiovasc Dev Dis. 2019 Feb 27;6(1). pii: E12. doi: 10.3390/jcdd6010012. Review.

PMID: 30818886 Free Article

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Select item 30807202

 

  1. Fetal and postnatal echocardiographic imaging of transposition of the great arteries with the aortic valve posterior to the pulmonary valve.

Castellanos DA, McKenzie ED, Morris SA.

Echocardiography. 2019 Feb 23. doi: 10.1111/echo.14292. [Epub ahead of print]

PMID: 30801777

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Select item 30833044

 

  1. Fetal iGRASP cine CMR assisting in prenatal diagnosis of complicated cardiac malformation with impact on delivery planning.

Bhat M, Haris K, Bidhult S, Liuba P, Aletras AH, Hedström E.

Clin Physiol Funct Imaging. 2019 Feb 20. doi: 10.1111/cpf.12566. [Epub ahead of print]

PMID: 30785656

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Select item 30820322

 

  1. A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement.

Jackson CB, Huemer M, Bolognini R, Martin F, Szinnai G, Donner BC, Richter U, Battersby BJ, Nuoffer JM, Suomalainen A, Schaller A.

Hum Mol Genet. 2019 Feb 15;28(4):639-649. doi: 10.1093/hmg/ddy374.

PMID: 30358850

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Select item 30307510

 

  1. In Utero Aortic Arch Thrombosis Masquerading as Interrupted Aortic Arch: A Case Report and Review of the Literature.

Knadler JJ, Zobeck M, Masand P, Sartain S, Kyle WB.

Pediatr Cardiol. 2019 Feb 8. doi: 10.1007/s00246-019-02068-5. [Epub ahead of print]

PMID: 30734851

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Select item 30735604

 

  1. Evaluation of septal insertion of atrioventricular valves in fetuses by postmortem 4.7 Tesla cardiac MRI: A feasibility study.

Blondiaux E, Autret G, Dhombres F, Gonzales M, Audureau E, Clément O, Jouannic JM, Houyel L.

Diagn Interv Imaging. 2019 Feb;100(2):109-116. doi: 10.1016/j.diii.2018.11.004. Epub 2018 Dec 7.

PMID: 30527913

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Select item 30316789

 

  1. Maturational patterns in right ventricular strain mechanics from the fetus to the young infant.

Erickson CT, Levy PT, Craft M, Li L, Danford DA, Kutty S.

Early Hum Dev. 2019 Feb;129:23-32. doi: 10.1016/j.earlhumdev.2018.12.015. Epub 2019 Jan 4.

PMID: 30616038

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Select item 30585348

 

  1. Prenatal diagnosis of congenital absence of aortic valve associated with restrictive foramen ovale: Hemodynamic features and clinical outcome.

Murakami T, Lin L, Ishiodori T, Takeuchi S, Shiono J, Horigome H.

J Clin Ultrasound. 2019 Feb;47(2):104-106. doi: 10.1002/jcu.22636. Epub 2018 Oct 14.

PMID: 30318622

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Select item 30522792

 

  1. Innovative 2-Step Management Strategy Utilizing EXIT Procedure for a Fetus With Hypoplastic Left Heart Syndrome and Intact Atrial Septum.

Said SM, Qureshi MY, Taggart NW, Anderson HN, O’Leary PW, Cetta F, Alrahmani L, Cofer SA, Segura LG, Pike RB, Sharpe EE, Derleth DP, Nemergut ME, Van Dorn CS, Gleich SJ, Rose CH, Collura CA, Ruano R.

Mayo Clin Proc. 2019 Feb;94(2):356-361. doi: 10.1016/j.mayocp.2018.08.004.

PMID: 30711131

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Select item 30394071

 

 

Congenital Cardiovascular Anesthesia and Critical Care Featured Articles

Congenital Cardiovascular Anesthesia

 

Congenital Heart anesthesia and critical care Feb 2019

 

  1. High-flow Nasal Cannula Versus Noninvasive ventilation for Postextubation Acute Respiratory Failure after Pediatric Cardiac Surgery.

Shioji N, Kanazawa T, Iwasaki T, Shimizu K, Suemori T, Kuroe Y, Morimatsu H.

Acta Med Okayama. 2019 Feb;73(1):15-20. doi: 10.18926/AMO/56454.

PMID: 30820050 Free Article

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Select item 30312493

 

  1. Selective Partial Obstruction of Inferior Vena Cava Blood Flow During Diastole: Cor Triatriatum Dexter, Large Eustachian Valve, or Chiari Network?

Pagel PS, Telles-Hernandez L, Miller R, Hill GED, Almassi GH.

J Cardiothorac Vasc Anesth. 2019 Feb;33(2):575-578. doi: 10.1053/j.jvca.2018.07.038. Epub 2018 Jul 29. No abstract available.

PMID: 30174263

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Select item 30072263

 

  1. Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery. Outcomes of Infant Cardiac Surgery for Congenital Heart Disease Concomitant With Persistent Pneumonia: A Retrospective Cohort Study.

Luo H, Qin G, Wang L, Ye Z, Pan Y, Huang L, Luo W, Guo Q, Peng Y, Wang E.

J Cardiothorac Vasc Anesth. 2019 Feb;33(2):428-432. doi: 10.1053/j.jvca.2018.05.039. Epub 2018 May 27.

PMID: 30055990 Free Article

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Select item 30259573

 

  1. Risk associated with anesthesia for non-cardiac surgery in children with congenital heart disease.

Taylor D, Habre W.

Paediatr Anaesth. 2019 Feb 1. doi: 10.1111/pan.13595. [Epub ahead of print]

PMID: 30710405

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Select item 30595509

 

  1. Respiratory Testing and Hospital Outcomes in Asymptomatic Infants Undergoing Heart Surgery.

Delgado-Corcoran C, Blaschke AJ, Ou Z, Presson AP, Burch PT, Pribble CG, Menon SC.

Pediatr Cardiol. 2019 Feb;40(2):339-348. doi: 10.1007/s00246-018-1994-5. Epub 2018 Oct 4.

PMID: 30288600

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Select item 30399019

 

  1. Preoperative cardiopulmonary evaluation in specific neonatal surgery.

Petroze RT, Puligandla PS.

Semin Pediatr Surg. 2019 Feb;28(1):3-10. doi: 10.1053/j.sempedsurg.2019.01.002. Epub 2019 Jan 18.

PMID: 30824131

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Select item 30824128

 

  1. Does heart rate variability improve prediction of failed extubation in preterm infants?

Silva MGF, Gregório ML, de Godoy MF.

J Perinat Med. 2019 Feb 25;47(2):252-257. doi: 10.1515/jpm-2017-0375.

PMID: 30183667

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Select item 30807544

 

  1. Extubation Failure Rates After Pediatric Cardiac Surgery Vary Across Hospitals.

Rooney SR, Donohue JE, Bush LB, Zhang W, Banerjee M, Pasquali SK, Gaies MG.

Pediatr Crit Care Med. 2019 Feb 25. doi: 10.1097/PCC.0000000000001877. [Epub ahead of print]

PMID: 30807544

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Select item 30799635

 

 

  1. A process for academic societies to develop scientific statements and white papers: experience of the Pediatric Cardiac Intensive Care Society.

Reddy S, Polito A, Staveski S, Dalton H.

Cardiol Young. 2019 Feb;29(2):174-177. doi: 10.1017/S1047951118002019. Epub 2018 Dec 4.

PMID: 30511598

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Select item 30457083

 

  1. Tetralogy of Fallot: Perioperative Management and Analysis of Outcomes.

Townsley MM, Windsor J, Briston D, Alegria J, Ramakrishna H.

J Cardiothorac Vasc Anesth. 2019 Feb;33(2):556-565. doi: 10.1053/j.jvca.2018.03.035. Epub 2018 Mar 24. Review. No abstract available.

PMID: 29706570

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Select item 30737152

 

  1. Brugada Syndrome: anesthetic considerations and management algorithm.

Espinosa Á, Ripollés-Melchor J, Brugada R, Campuzano Ó, Sarquella-Brugada G, Abad-Motos A, Zaballos-García M, Abad-Torrent A, Prieto-Gundin A, Brugada J.

Minerva Anestesiol. 2019 Feb;85(2):173-188. doi: 10.23736/S0375-9393.18.13170-1. Epub 2018 Oct 30.

PMID: 30394071

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Select item 30667207

 

  1. Positive Airway Pressure Versus High-Flow Nasal Cannula for Prevention of Extubation Failure in Infants After Congenital Heart Surgery.

Richter RP, Alten JA, King RW, Gans AD, Rahman AF, Kalra Y, Borasino S.

Pediatr Crit Care Med. 2019 Feb;20(2):149-157. doi: 10.1097/PCC.0000000000001783.

PMID: 30407954

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Select item 3074682

 

The CHIP Network Journal Watch Team

Konstantin Averin, MD, MS is an Associate Professor of Pediatrics at the University of Alberta and an Interventional Pediatric Cardiologist at the Stollery Children’s Hospital in Edmonton, Alberta. He received his medical degree from the Feinberg School of Medicine at Northwestern University in Chicago, IL. After medical school, he completed pediatrics residency, pediatric cardiology fellowship and sub-specialty training in pediatric and adult interventional cardiology at the Cincinnati Children’s Hospital in Cincinnati, OH. His clinical and research interests are focused on the percutaneous treatment of pediatric patients with congenital and acquired heart disease with a focus on patients with single ventricle physiology, transcatheter pulmonary valves, and pulmonary hypertension.

Dr. Leong Ming Chern “MC” is an adult congenital heart disease specialist at the National Heart Institute, Kuala Lumpur, Malaysia. He received his medical training at the University of Malaya and pediatric cardiology training at the National Heart Institute. His area of interest includes treatment of adult patients with congenital heart disease and pulmonary hypertension in congenital heart disease.

Dr. Damien Cullington, MBChB MRCP MD FESC is a consultant adult congenital cardiologist who works at Leeds General Infirmary, UK. In summer 2019, he will move over to the newly commissioned North West ACHD Service based in Liverpool, UK. Damien qualified in 2002 from the University of Liverpool and became a substantive consultant in 2016. Prior to this, he worked throughout the North of England and Yorkshire as a cardiology trainee. Damien was awarded a doctorate in medicine (MD) from the University of Hull in 2013 for his work in heart rate in patients with heart failure. He is a member of the Royal College of Physicians (London), Fellow of the European Society of Cardiology and honorary senior lecturer for the University of Leeds. His ACHD subspecialty clinical interests are heart failure, imaging and palliative care. He is regional organiser for ACHD training at Leeds and clinical governance lead for the Leeds congenital cardiac unit. His research interests and wide and far but particularly epidemiology, chronic heart failure in ACHD patients in all its guises, the systemic RV and the univentricle

Dr. Blanche Cupido is a consultant adult cardiologist working at Groote Schuur Hospital, UCT Private Academic Hospital and the University of Cape Town(UCT), South Africa. She completed her physician training in 2009 and her cardiology subspecialist training in 2013. She recently returned to SA after doing a Fellowship in Adult Congenital Heart Disease in Leeds, United Kingdom under the guidance of Dr Kate English. She has established a dedicated unit for Grown Up Congenital Heart Disease in Cape Town, South Africa. Her aim is to grow ACHD services in Sub-Saharan Africa and embark on GUCH research on the African continent.

Dr. Jeremy L. Herrmann is an Assistant Professor of Surgery in the Division of Thoracic and Cardiovascular Surgery at Indiana University. He specializes in pediatric and adult congenital cardiac surgery, and his clinical interests also include heart transplantation and mechanical circulatory support. His hospital affiliations include Indiana University Health Riley Hospital for Children and Methodist Hospital as well as Peyton Manning Children’s Hospital at St. Vincent Hospital in Indianapolis

Maan Jokhadar is a cardiologist and associate professor of medicine at Emory University in Atlanta, Georgia. He is board certified in internal medicine, cardiovascular disease, advanced heart failure/transplantation, adult congenital heart disease, and echocardiography. He is fellowship director for the Emory Adult Congenital Heart Disease training program and Core Curriculum Director for the Emory general cardiology fellowship program. Dr Jokhadar graduated from the University Damascus School of Medicine in Syria and then went to Mayo Clinic in Rochester, Minnesota for internal medicine residency. He then completed cardiology and subspecialty training at Emory University, where he currently on faculty. Dr. Jokhadar has been the recipient of numerous teaching awards. He is married with 3 children.

Michael Ma, MD is an Assistant Professor in Cardiothoracic Surgery in the Division of Pediatric Cardiac Surgery at Stanford University. He specializes in pediatric and adult congenital cardiac surgery, with an emphasis on neonates, complex biventricular repair, and pulmonary artery reconstruction. His research lab investigates ex and in vivo translational models for complex congenital heart disease, to optimize future surgical and endovascular repair strategies.

Jeremy P. Moore MD MS FHRS is the Director of Clinical Research and faculty in Pediatric Cardiology and Adult Congenital Heart Disease at the University of California, Los Angeles. Dr. Moore received his medical degree from the Medical College of Virginia in 2003. He completed residency and fellowship at UCLA before pursuing his subspecialty training in Pediatric Electrophysiology at Vanderbilt University in 2009. Dr. Moore has been faculty at UCLA since 2010 and has since published numerous research manuscripts dealing with electrophysiologic aspects pertinent to congenital heart disease. Dr. Moore’s primary interest is the study of mechanisms of arrhythmia, and the development of novel electrophysiologic techniques for management of the adult patient with congenital heart disease

Dr. Mehul Patel MD, is a structural and adult congenital heart disease specialist and an interventional cardiologist. Dr. Patel earned his undergraduate and medical education from the Mumbai University, India. After completing his post-graduate training in Internal Medicine and Cardiology, he further trained in interventional cardiology at the Mount Sinai Medical Center, NYC, NY and Adult Congenital Heart Disease at the Texas Children’s Hospital, Texas Heart Institute, Baylor College of Medicine, Houston, TX. Dr. Patel worked as Chief of adult congenital heart disease, Assistant Professor at the Michigan State University, Grand Rapids, MI where he not only expanded the program, performing complex interventions and device implantations but also established the percutaneous pulmonary valve implantation (Melody Valve) Program. Due to his passion for treating structurally abnormal hearts, he did a dedicated year of Structural Heart Disease fellowship at Henry Ford Hospital, Detroit, MI where he worked with pioneers in this field before moving to North Carolina. He is proficient in performing transcatheter aortic valve replacement (TAVR), MitraClip, Watchman device implantation, percutaneous Mitral, Tricuspid and Pulmonary valve replacements along with a variety of interventions on congenital heart disease and pulmonary hypertension. Dr. Patel is ABIM board certified in Internal Medicine, Cardiology, Interventional cardiology and Adult Congenital Heart Disease. Dr. Patel has more than 50 peer reviewed publications and numerous abstracts to his credit. He serves as a Co-Editor-in-Chief for the CHiP Network journal watch. His wife, Khyati is a pediatric cardiac Electrophysiologist and they have a 9-year-old daughter. Dr. Patel is also an artist, likes music, yoga and plays badminton. His clinical areas of expertise and interests are: 1) Transcatheter therapies for Structural and Adult Congenital heart disease. 2) Complex device implantations.

Dr. Timothy Pirolli is an Assistant Professor of Surgery in the Division of Pediatric Cardiothoracic Surgery at University of Texas Southwestern Medical Center. He specializes in pediatric and adult congenital cardiac surgery. His hospital affiliations include Children’s Medical Center in Dallas, Parkland Memorial Hospital, and Clements University Hospital (UTSW).

Dr. Inga Voges, M.D. Consultant in Pediatric Cardiology, Lead Consultant Cardiovascular MRI. I trained in General Pediatrics and Pediatric Cardiology in Rostock (Germany) and Kiel (Germany) from 2002-2010 and did additional training in Adult Congenital Heart Disease (ACHD) in Kiel (Germany) which I finished in 2014. I specialized in Cardiovascular Magnetic Resonance Imaging (CMR) and have a further special interest in cardiomyopathies. Currently, I am working as a consultant pediatric and ACHD cardiologist at the University Hospital Schleswig-Holstein (Kiel, Germany) where I am responsible for the CMR imaging program in pediatric and ACHD patients and contribute to the care of patients with acquired and congenital heart disease. I received my MD from the Medical University Luebeck in 2006 (Germany) and finished my “Habilitation” (PhD equivalent; University Hospital Kiel, Germany) in 2014. Since 2016, I am the secretary of the Association for European Paediatric and Congenital Cardiology Imaging Working Group.

Dr. Gary Webb, M.D. is an Emeritus Professor of Pediatrics and Internal Medicine at the University of Cincinnati College of Medicine and,
from 2009-2016, the Director of the Adult Congenital Heart Program at Cincinnati Children’s Hospital Heart Institute. A graduate of McGill
University in Montréal, he interned at the Royal Victoria Hospital, and then trained in internal medicine and cardiology at the University of Toronto. From 1980-2004, he was co-director and then director of the Toronto Congenital Cardiac Center for Adults at Toronto General Hospital. He is a Fellow of the Royal College of Physicians and Surgeons of Canada in both internal medicine and cardiology. From 2004-2009, he was director of the Philadelphia Adult Congenital Heart Center at the University of Pennsylvania. Since 2016, he has been a consultant to Cincinnati Children’s Hospital, and has been responsible for the ACHD Learning Center, the Cardiology Fellow Testing Center, and the Congenital Heart Professionals International (CHIP) Network. Since 2017, he has resumed seeing patients on a part-time basis at the Toronto Congenital Cardiac Centre for Adults.

Wendy Whiteside, MD Wendy is Assistant Professor of Pediatrics and Associate Director of Interventional Pediatric Cardiology at the University of Michigan Congenital Heart Center, C.S. Mott Children’s Hospital. She obtained her medical degree from Albert Einstein College of Medicine in 2006 then completed pediatric residency at Children’s Hospital Oakland in Oakland, CA in 2009. She received
both her categorical and interventional pediatric cardiology training at the University of Michigan in Ann Arbor, MI. Her clinical and research interests include single ventricle physiology, transcatheter
pulmonary valves, and quality improvement within the cardiac catheterization laboratory.

About the Congenital Heart and Pediatric Cardiac Journal Watch

Congenital heart and pediatric cardiac Journal Watch was designed to make it easier for congenital heart and pediatric cardiac professionals to keep up with the literature in 6 subsections of congenital heart disease abstracts on a monthly basis: pediatric cardiology; congenital heart surgery; congenital  heart interventions; congenital/pediatric electrophysiology; fetal cardiology; and adult congenital heart disease.

We encourage your continued support as well as your valuable comments and feedback.

Learn More

Sincerely,

Dr. Gary Webb, MD and Dr. Mehul Patel
CHiP Network
Congenital Heart and Pediatic Cardiac Journal Watch Editorial Board

The Chip Network, the Congenital Heart International Professionals Network, aims to develop a single global list of all congenital and pediatric cardiac professionals.

We invite you to share this with your colleagues.